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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL18 Gene

protein-coding   GIFtS: 69
GCID: GC11M112013

Interleukin 18 (Interferon-Gamma-Inducing Factor)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 18 (Interferon-Gamma-Inducing Factor)1 2     IL-1 Gamma2 3
IGIF2 3 5     IL-1g2
Interleukin-1 Gamma2 3     iboctadekin2
IL-182 3     interleukin-182
IL1F42 3     Iboctadekin3
IFN-Gamma-Inducing Factor2 3     Interferon Gamma-Inducing Factor3

External Ids:    HGNC: 59861   Entrez Gene: 36062   Ensembl: ENSG000001507827   OMIM: 6009535   UniProtKB: Q141163   

Export aliases for IL18 gene to outside databases

Previous GC identifers: GC11M114366 GC11M113526 GC11M112047 GC11M111551 GC11M111519 GC11M107938


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL18 Gene:
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in
spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Aug 2011)

GeneCards Summary for IL18 Gene: 
IL18 (interleukin 18 (interferon-gamma-inducing factor)) is a protein-coding gene. Diseases associated with IL18 include adult-onset still's disease, and pleural tuberculosis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Th1 Differentiation. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot: IL18_HUMAN, Q14116
Function: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in
T-helper type I cells

Gene Wiki entry for IL18 (Interleukin 18) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL18 gene promoter:
         TBP   AP-1   ATF-2   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL18 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.2-q22.3   Ensembl cytogenetic band:  11q23.1   HGNC cytogenetic band: 11q22.2-q22.3

IL18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL18 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M112013:  view genomic region     (about GC identifiers)

Start:
112,013,974 bp from pter      End:
112,034,840 bp from pter
Size:
20,867 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL18_HUMAN, Q14116 (See protein sequence)
Recommended Name: Interleukin-18 precursor  
Size: 193 amino acids; 22326 Da
Subcellular location: Secreted
6 PDB 3D structures from and Proteopedia for IL18:
1J0S (3D)        2VXT (3D)        3F62 (3D)        4EEE (3D)        4EKX (3D)        4HJJ (3D)    
Secondary accessions: O75599 Q6FGY3 Q6WWJ7
Alternative splicing: 2 isoforms:  Q14116-1   Q14116-2   (Expressed in ovarian carcinoma but undetectable in normal ovarian epithelial cells. Resistant to proteolytic activation by caspase-1 and -4)

Explore the universe of human proteins at neXtProt for IL18: NX_Q14116

Explore proteomics data for IL18 at MOPED 

Post-translational modifications:

  • UniProtKB: The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14116

  • IL18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL18 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001230140.1  NP_001553.1  

    ENSEMBL proteins: 
     ENSP00000280357   ENSP00000434561   ENSP00000434161  
    Reactome Protein details: Q14116
    Human Recombinant Protein Products for IL18: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL18 (IL-18/IL-1F4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IL18
    OriGene Protein Over-expression Lysate for IL18
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    Novus Biologicals IL18 Proteins
    Novus Biologicals IL18 Lysate
    Sino Biological Recombinant Protein for IL18
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for IL18
    Cloud-Clone Corp. Proteins for IL18 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS11598150
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0016324apical plasma membrane IEA--

    IL18 for ontologies           About GeneDecksing



    IL18 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL18
    R&D Systems Antibodies for IL18 (IL-18/IL-1F4)
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    Novus Biologicals IL18 Antibody
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    Cloud-Clone Corp. Antibodies for IL18 
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    LSBio Antibodies in human, mouse, rat for IL18 

    Assay Products for IL18: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL18 
    Cloud-Clone Corp. CLIAs for IL18


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IL: Interleukins and interleukin receptors

    3 InterPro protein domains:
     IPR015529 Interleukin_18
     IPR000975 Interleukin_1
     IPR008996 Cytokine_IL1-like

    Graphical View of Domain Structure for InterPro Entry Q14116

    ProtoNet protein and cluster: Q14116

    1 Blocks protein domain: IPB000975 Interleukin-1 precursor family signature

    UniProtKB/Swiss-Prot: IL18_HUMAN, Q14116
    Similarity: Belongs to the IL-1 family


    IL18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL18_HUMAN, Q14116
    Function: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in
    T-helper type I cells

         Genatlas biochemistry entry for IL18:
    interleukin 18,interferon-gamma inducing factor,involved in Th1-mediated cellular immunity

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity TAS11598150
    GO:0005515protein binding ----
         
    IL18 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IL18:
     Increased gamma-H2AX phosphory 

         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Il18):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     muscle  nervous system  vision/eye 

    IL18 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IL18: Il18tm1Khe Il18tm1Aki

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL18 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL18 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL18 

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    miRTarBase miRNAs that target IL18:
    hsa-mir-346 (MIRT004304)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL18
    1 QIAGEN miScript miRNA Assays for microRNA that regulate IL18:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL18 3' UTR sequence
    Inhib. RNA
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    Sirion Biotech Customized lentivirus for stable overexpression of IL18 
                         Customized lentivirus expression plasmids for stable overexpression of IL18 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL18


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL18 About   (see all 28)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2IL27-mediated signaling events
    IL27-mediated signaling events0.38
    Th1 Differentiation0.38
    3Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    NOD-like receptor signaling pathway0.37
    NOD pathway0.33
    4Immune response IL-12-induced IFN-gamma production
    Immune response IL-12-induced IFN-gamma production0.88
    IL12-mediated signaling events0.33
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    MAPK Family Pathway0.60
    SOCS Pathway0.40
    JAK-STAT Pathway0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for IL18
        Immune response IL-12-induced IFN-gamma production

    4 R&D Systems Pathways for IL18
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    Th1 Differentiation
    Toll-Like receptor Signaling Pathways

    5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL18 (see all 27)
        THC Differentiation Pathway
    MSP-RON Signaling
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    1 GeneGo (Thomson Reuters) Pathway for IL18
        Immune response IL-12-induced IFN-gamma production

    5/6 BioSystems Pathways for IL18 (see all 6)
        NOD pathway
    IL23-mediated signaling events
    Cellular roles of Anthrax toxin
    IL12-mediated signaling events
    IL27-mediated signaling events


    4        Reactome Pathways for IL18
        Interleukin-1 processing
    Cytokine Signaling in Immune system
    Signaling by Interleukins
    Immune System


    5/11         Kegg Pathways  (Kegg details for IL18) (see all 11):
        Cytokine-cytokine receptor interaction
    NOD-like receptor signaling pathway
    Cytosolic DNA-sensing pathway
    Salmonella infection
    Legionellosis


    IL18 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/21 Interacting proteins for IL18 (Q141163 ENSP000002803574) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP4P496623, ENSP000003885664I2D: score=4 STRING: ENSP00000388566
    CASP3P425743, ENSP000003110324I2D: score=3 STRING: ENSP00000311032
    CASP1P294663, ENSP000004100764I2D: score=4 STRING: ENSP00000410076
    IL18BPO959983, ENSP000002600494I2D: score=2 STRING: ENSP00000260049
    IL18R1Q134783, ENSP000002339574I2D: score=3 STRING: ENSP00000233957
    About this table

    Gene Ontology (GO): 5/54 biological process terms (GO ID links to tree view) (see all 54):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IMP--
    GO:0001525angiogenesis IDA11466388
    GO:0001649osteoblast differentiation IEA--
    GO:0001666response to hypoxia IEA--
    GO:0006954inflammatory response IDA--

    IL18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL18 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL18

    10/136 Novoseek inferred chemical compound relationships for IL18 gene (see all 136)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    il-12 69.2 23 15122806 (3), 18765427 (2), 12002384 (2), 17324967 (2) (see all 16)
    lfa703 66.9 7 15618295 (6), 17482516 (1)
    il 10 60.7 15 17324967 (2), 20083555 (2), 15281432 (1), 16759385 (1) (see all 12)
    rantes 57.3 44 19323903 (4), 15645140 (3), 17623049 (2), 15975968 (2) (see all 30)
    pralnacasan 55.1 1 14610233 (1)
    ccl3 47.2 1 17170049 (1)
    anakinra 46.3 1 17583775 (1)
    imidazoquinoline 44.6 2 16407888 (1), 15544517 (1)
    ifn-alpha 40.3 6 18765427 (3), 12220554 (1), 15663652 (1), 14978071 (1)
    4-methylhistamine 36.2 1 10843724 (1)

    Search CenterWatch for drugs/clinical trials and news about IL18

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL18 gene (2 alternative transcripts): 
    NM_001243211.1  NM_001562.3  

    Unigene Cluster for IL18:

    Interleukin 18 (interferon-gamma-inducing factor)
    Hs.83077  [show with all ESTs]
    Unigene Representative Sequence: NM_001562
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280357(uc001pnb.2 uc009yym.2) ENST00000524595 ENST00000525547(uc001pna.2)
    ENST00000528832 ENST00000533858 ENST00000534225
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate IL18:
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF077611.1 AF380360.1 AK311301.1 AY044641.1 AY266351.1 BC007007.1 BC007461.1 CR541973.1 
    CR542001.1 D49950.1 U90434.1 

    8 DOTS entries:

    DT.203558  DT.120733823  DT.120733704  DT.100718627  DT.40246703  DT.95094414  DT.91740655  DT.97788905 

    24/76 AceView cDNA sequences (see all 76):

    NM_001562 AY266351 CR541973 CR542001 BM849891 BF590479 AI394321 AY044641 
    U90434 BG681242 BM849862 BG751576 D49950 BQ082738 BQ427550 BU602301 
    BG207982 BU633686 BM767222 BG197557 BG500265 BF968230 BM856014 BG776256 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IL18    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
    SP1:              -           -     -     -                     
    SP2:              -           -                                 
    SP3:              -                                             
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for IL18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL18 expression in normal human tissues (normalized intensities)      IL18 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTCAATCC
    IL18 Expression
    About this image


    IL18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Podocytes Podocyte Layer
             kidney ; cells in tubules   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   

    See IL18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL18

    SOURCE GeneReport for Unigene cluster: Hs.83077
        SABiosciences Expression via Pathway-Focused PCR Arrays including IL18 (see all 18): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Inflammasomes in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Th17 Response in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL18 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il181 , 5 interleukin 181, 5 75.77(n)1
    66.12(a)1
      9 (27.75 cM)5
    161731  NM_008360.11  NP_032386.11 
     505752735 
    chicken
    (Gallus gallus)
    Aves IL186
    interleukin-18
    31(a)
    1 ↔ 1
    24(6163150-6165998)
    lizard
    (Anolis carolinensis)
    Reptilia IL186
    Uncharacterized protein
    28(a)
    1 ↔ 1
    GL343973.1(59639-61532)


    ENSEMBL Gene Tree for IL18 (if available)
    TreeFam Gene Tree for IL18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL18 gene
    1 SIMAP similar gene for IL18 using alignment to 2 protein entries:     IL18_HUMAN (see all proteins):
    IL-18

    IL18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/506 SNPs in IL18 are shown (see all 506)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1114800831,2
    C,F--111877238(+) TATCAA/GTATCT 2 -- ds50012Minor allele frequency- G:0.09CSA WA 120
    rs1889633691,2
    --111877242(+) AATATA/CTTTTG 2 -- ds50010--------
    rs57442941,2
    C,F--111877308(-) TAATTG/AGCATA 2 -- ds50014Minor allele frequency- A:0.04NA EU WA 212
    rs49371001,2
    C,F,A--111877341(+) TATGAA/GTTTTT 2 -- ds500112Minor allele frequency- G:0.46NA EU NS WA EA 504
    rs1502894941,2
    C--111877398(+) AAGTC-/TGTT  
            
    TGTTT
    2 -- ds50010--------
    rs557820761,2
    C--111877495(+) ATAATC/TTCATA 2 -- ds50010--------
    rs1930685471,2
    --111877522(+) AAATTA/CAGACA 2 -- ds50010--------
    rs3607271,2
    C,F,A--111877644(-) GAGGTG/AGAGGT 2 -- ut31 ese312Minor allele frequency- A:0.03NA EU WA CSA EA 227
    rs1853096901,2
    --111877686(+) CTTGAA/GTAGCT 2 -- ut310--------
    rs57442921,2
    C,F--111877691(-) ATCCCA/GGCTAC 2 -- ut31 ese311Minor allele frequency- G:0.23NA EU MN NS 446

    HapMap Linkage Disequilibrium report for IL18 (112013974 - 112034840 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IL18:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745077CNV Deletion23290073
    nsv519192CNV Gain19592680


    Human Gene Mutation Database (HGMD): IL18
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IL18
    DNA2.0 Custom Variant and Variant Library Synthesis for IL18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600953    OMIM disorders: --

    20/247 diseases for IL18 (see all 247):    About MalaCards
    adult-onset still's disease    pleural tuberculosis    mercury poisoning    uremic pruritus
    miliary tuberculosis    stachybotrys chartarum    schnitzler syndrome    molluscum contagiosum
    leptin deficiency    acute graft versus host disease    large granular lymphocyte leukemia    lupus nephritis
    t-cell large granular lymphocyte leukemia    chronic infantile neurological cutaneous articular syndrome    eosinophilic pneumonia    periventricular leukomalacia
    salmonellosis    rosacea    nonspecific interstitial pneumonia    cysticercosis

    3 diseases from the University of Copenhagen DISEASES database for IL18:
    Arthritis     Atherosclerosis     Hypersensitivity reaction type II disease

    IL18 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/95 Novoseek inferred disease relationships for IL18 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 74.3 262 12798479 (4), 17100768 (3), 12492197 (3), 12010883 (3) (see all 99)
    stills disease adult-onset 73.5 24 11263769 (2), 18050226 (2), 15934126 (2), 16563174 (1) (see all 16)
    necrosis 71.5 290 11923692 (2), 17189537 (2), 17608757 (2), 20096599 (2) (see all 99)
    rheumatoid arthritis 63.9 123 15320916 (3), 15172050 (2), 14872485 (2), 16368150 (2) (see all 73)
    autoimmune diseases 55.2 53 11315928 (4), 11641240 (3), 11673550 (3), 17143689 (2) (see all 30)
    tumors 52.2 381 12918059 (7), 17016692 (5), 15004655 (4), 10371355 (4) (see all 99)
    dermatitis atopic 51.8 43 18094564 (5), 17323858 (3), 11600194 (2), 11490156 (2) (see all 26)
    atherosclerosis 46.6 69 18590113 (4), 20350254 (3), 15860738 (3), 17626902 (3) (see all 33)
    lupus erythematosus systemic 46.3 33 18250135 (2), 19758166 (2), 19605669 (2), 17361200 (2) (see all 21)
    pleurisy tuberculous 43.9 3 16256041 (1), 12472673 (1), 18663530 (1)

    Genetic Association Database (GAD): IL18
    Human Genome Epidemiology (HuGE) Navigator: IL18 (224 documents)

    Export disorders for IL18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL18 gene, integrated from 9 sources (see all 1998):
    (articles sorted by number of sources associating them with IL18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. [Correlations between serum interleukin-18 (IL-18) le vel, IL-18 gene promoter polymorphisms and the development of sepsis in childre n] (PubMed id 20441695)1, 4, 9 Cai L.L....Zeng X. (2010)
    2. IL18 haplotypes are associated with serum IL-18 concentrations in a population-based study and a cohort of individuals with premature coronary heart disease. (PubMed id 17962365)1, 4, 9 Thompson S.R....Humphries S.E. (2007)
    3. [Correlation of serum IL-18 level and IL-18 gene promoter polymorphisms to the risk of cervical cancer] (PubMed id 18504197)1, 4, 9 Qi T....Bao J. (2008)
    4. Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease. (PubMed id 16043644)1, 4, 9 Tiret L....Blankenberg S. (2005)
    5. Levels of interleukin-18 are markedly increased in Helicobacter pylori-infected gastric mucosa among patients with specific IL18 genotypes. (PubMed id 18442334)1, 4, 9 Sakai K....Yamaoka Y. (2008)
    6. Interleukin-10 and interleukin-18 promoter polymorphisms in an Italian cohort of patients with undifferentiated carcinoma of nasopharyngeal type. (PubMed id 16059673)1, 4, 9 Pratesi C....De Paoli P. (2006)
    7. Roles of functional polymorphisms in the interleukin-18 gene promoter in sarcoidosis. (PubMed id 16053025)1, 4, 9 Zhou Y....Nishimura M. (2005)
    8. Association of polymorphisms of interleukin-18 gene promoter region with chronic hepatitis B in Chinese Han population. (PubMed id 15786533)1, 4, 9 Zhang P.A....Yang X.S. (2005)
    9. Interleukin-18 gene polymorphism and markers of subcl inical atherosclerosis. The Cardiovascular Risk in Young Finns Study. (PubMed id 20350254)1, 4, 9 Hernesniemi J.A....LehtimAoki T. (2010)
    10. Association of IL-18 gene polymorphism (-137C) with arthritis manifestations in SLE: combined effect with IFN gamma gene polymorphism (+874A). (PubMed id 19031096)1, 4, 9 Hirankarn N....Avihingsanon Y. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3606 HGNC: 5986 AceView: IL18 Ensembl:ENSG00000150782 euGenes: HUgn3606
    ECgene: IL18 Kegg: 3606 H-InvDB: IL18

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL18 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL18 gene:
    Search GeneIP for patents involving IL18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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