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IL18 Gene

protein-coding   GIFtS: 69
GCID: GC11M112013

Interleukin 18 (Interferon-Gamma-Inducing Factor)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Interleukin 18 (Interferon-Gamma-Inducing Factor)1 2     IL-1 Gamma2 3
IGIF2 3 5     IL-1g2
Interleukin-1 Gamma2 3     iboctadekin2
IL-182 3     interleukin-182
IL1F42 3     Iboctadekin3
IFN-Gamma-Inducing Factor2 3     Interferon Gamma-Inducing Factor3

External Ids:    HGNC: 59861   Entrez Gene: 36062   Ensembl: ENSG000001507827   OMIM: 6009535   UniProtKB: Q141163   
ORGUL members:         

Export aliases for IL18 gene to outside databases

Previous GC identifers: GC11M114366 GC11M113526 GC11M112047 GC11M111551 GC11M111519 GC11M107938


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL18 Gene:
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in
spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Aug 2011)

GeneCards Summary for IL18 Gene:
IL18 (interleukin 18 (interferon-gamma-inducing factor)) is a protein-coding gene. Diseases associated with IL18 include adult-onset still's disease, and mercury poisoning. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot: IL18_HUMAN, Q14116
Function: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in
T-helper type I cells

Gene Wiki entry for IL18 (Interleukin 18) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL18 gene promoter:
         TBP   AP-1   ATF-2   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL18 promoter sequence
   Search Chromatin IP Primers for IL18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.2-q22.3   Ensembl cytogenetic band:  11q23.1   HGNC cytogenetic band: 11q22.2-q22.3

IL18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL18 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M112013:  view genomic region     (about GC identifiers)

Start:
112,013,974 bp from pter      End:
112,034,840 bp from pter
Size:
20,867 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IL18_HUMAN, Q14116 (See protein sequence)
Recommended Name: Interleukin-18 precursor  
Size: 193 amino acids; 22326 Da
6 PDB 3D structures from and Proteopedia for IL18:
1J0S (3D)        2VXT (3D)        3F62 (3D)        4EEE (3D)        4EKX (3D)        4HJJ (3D)    
Secondary accessions: O75599 Q6FGY3 Q6WWJ7
Alternative splicing: 2 isoforms:  Q14116-1   Q14116-2   (Expressed in ovarian carcinoma but undetectable in normal ovarian epithelial cells. Resistant to proteolytic activation by caspase-1 and -4)

Explore the universe of human proteins at neXtProt for IL18: NX_Q14116

Explore proteomics data for IL18 at MOPED

Post-translational modifications: 

  • The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IL18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230140.1  NP_001553.1  

    ENSEMBL proteins: 
     ENSP00000280357   ENSP00000434561   ENSP00000434161  
    Reactome Protein details: Q14116

    IL18 Human Recombinant Protein Products:

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    R&D Systems Recombinant & Natural Proteins for IL18 (IL-18/IL-1F4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IL18
    OriGene Protein Over-expression Lysate for IL18
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    GenScript Purified and Recombinant Proteins for IL18
    Novus Biologicals IL18 Proteins
    Novus Biologicals IL18 Lysate
    Sino Biological Recombinant Protein for IL18
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for IL18
    Cloud-Clone Corp. Proteins for IL18

    IL18 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL18
    R&D Systems Antibodies for IL18 (IL-18/IL-1F4)
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    IL18 Assay Products:

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    GenScript Custom Assay Services for IL18
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL18
    Cloud-Clone Corp. CLIAs for IL18


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    3 InterPro protein domains:
     IPR015529 IL-18
     IPR000975 IL-1
     IPR008996 Cytokine_IL1-like

    Graphical View of Domain Structure for InterPro Entry Q14116

    ProtoNet protein and cluster: Q14116

    1 Blocks protein domain: IPB000975 Interleukin-1 precursor family signature

    UniProtKB/Swiss-Prot: IL18_HUMAN, Q14116
    Similarity: Belongs to the IL-1 family


    IL18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL18_HUMAN, Q14116
    Function: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in
    T-helper type I cells

         Genatlas biochemistry entry for IL18:
    interleukin 18,interferon-gamma inducing factor,involved in Th1-mediated cellular immunity

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity TAS11598150
         
    IL18 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IL18:
     Increased gamma-H2AX phosphory 

         14 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Il18):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  integument 
     mortality/aging  muscle  nervous system  vision/eye 

    IL18 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IL18: Il18tm1Khe Il18tm1Aki

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL18
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL18
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL18

    miRNA
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    miRTarBase miRNAs that target IL18:
    hsa-mir-346 (MIRT004304)

    Block miRNA regulation of human, mouse, rat IL18 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate IL18:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL18 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL18
    Predesigned siRNA for gene silencing in human, mouse, rat IL18

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL18

    Clone
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    OriGene clones in human, mouse for IL18 (see all 6)
    OriGene ORF clones in mouse, rat for IL18
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    GenScript: all cDNA clones in your preferred vector: IL18 (NM_001562)
    Sino Biological Human cDNA Clone for IL18
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL18

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IL18 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL18_HUMAN, Q14116: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol4
    golgi apparatus3
    nucleus3
    plasma membrane2
    cytoskeleton1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS11598150
    GO:0005615extracellular space IEA--
    GO:0005829cytosol TAS--
    GO:0016324apical plasma membrane ----

    IL18 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL18 About   (see all 28)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Th1 Differentiation
    IL27-mediated signaling events0.38
    Th1 Differentiation0.38
    3Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    NOD-like receptor signaling pathway0.37
    NOD pathway0.33
    4IL12-mediated signaling events
    Immune response IL 12 induced IFN gamma production0.33
    IL12-mediated signaling events0.33
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    MAPK Family Pathway0.60
    SOCS Pathway0.40
    JAK-STAT Pathway0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 R&D Systems Pathways for IL18
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-1 Family Signaling Pathways
    Th1 Differentiation
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL18 (see all 27)
        THC Differentiation Pathway
    MSP-RON Signaling
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    1 GeneGo (Thomson Reuters) Pathway for IL18
        Immune response IL-12-induced IFN-gamma production

    Selected BioSystems Pathways for IL18 (see all 8)
        NOD pathway
    Hypertrophy Model
    Corticotropin-releasing hormone
    IL27-mediated signaling events
    IL12-mediated signaling events


    1 Reactome Pathway for IL18
        Interleukin-1 processing


    Selected Kegg Pathways  (Kegg details for IL18) (see all 11):
        Cytokine-cytokine receptor interaction
    NOD-like receptor signaling pathway
    Cytosolic DNA-sensing pathway
    Salmonella infection
    Legionellosis


    IL18 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL18 (see all 18): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Inflammasomes in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Th17 Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for IL18 (Q141163 ENSP000002803574) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP4P496623, ENSP000003885664I2D: score=4 STRING: ENSP00000388566
    CASP3P425743, ENSP000003110324I2D: score=3 STRING: ENSP00000311032
    CASP1P294663, ENSP000004100764I2D: score=4 STRING: ENSP00000410076
    IL18BPO959983, ENSP000002600494I2D: score=2 STRING: ENSP00000260049
    IL18R1Q134783, ENSP000002339574I2D: score=3 STRING: ENSP00000233957
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 52):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IMP--
    GO:0001525angiogenesis IDA11466388
    GO:0001649osteoblast differentiation ----
    GO:0001666response to hypoxia ----
    GO:0006954inflammatory response IDA--

    IL18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL18

    Selected Novoseek inferred chemical compound relationships for IL18 gene (see all 136)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    il-12 69.2 23 15122806 (3), 18765427 (2), 12002384 (2), 17324967 (2) (see all 16)
    lfa703 66.9 7 15618295 (6), 17482516 (1)
    il 10 60.7 15 17324967 (2), 20083555 (2), 15281432 (1), 16759385 (1) (see all 12)
    rantes 57.3 44 19323903 (4), 15645140 (3), 17623049 (2), 15975968 (2) (see all 30)
    pralnacasan 55.1 1 14610233 (1)
    ccl3 47.2 1 17170049 (1)
    anakinra 46.3 1 17583775 (1)
    imidazoquinoline 44.6 2 16407888 (1), 15544517 (1)
    ifn-alpha 40.3 6 18765427 (3), 12220554 (1), 15663652 (1), 14978071 (1)
    4-methylhistamine 36.2 1 10843724 (1)



    IL18 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IL18 gene (2 alternative transcripts): 
    NM_001243211.1  NM_001562.3  

    Unigene Cluster for IL18:

    Interleukin 18 (interferon-gamma-inducing factor)
    Hs.83077  [show with all ESTs]
    Unigene Representative Sequence: NM_001562
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280357(uc001pnb.2 uc009yym.2) ENST00000524595 ENST00000525547(uc001pna.2)
    ENST00000528832 ENST00000533858 ENST00000534225
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate IL18:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL18 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat IL18

    Additional mRNA sequence: 

    AF077611.1 AF380360.1 AK311301.1 AY044641.1 AY266351.1 BC007007.1 BC007461.1 CR541973.1 
    CR542001.1 D49950.1 U90434.1 

    8 DOTS entries:

    DT.203558  DT.120733823  DT.120733704  DT.100718627  DT.40246703  DT.95094414  DT.91740655  DT.97788905 

    Selected AceView cDNA sequences (see all 76):

    AI394321 BQ427550 BM849891 BG751576 AY266351 BF590479 BQ082738 BG681242 
    CR541973 NM_001562 D49950 AY044641 BM849862 CR542001 U90434 BM782049 
    BU602301 BM926493 BG207982 BG197058 AA359883 CD366299 CD368641 BG197557 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IL18    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
    SP1:              -           -     -     -                     
    SP2:              -           -                                 
    SP3:              -                                             
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for IL18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTCAATCC
    IL18 Expression
    About this image


    IL18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Epithelial Cells
             Podocytes Podocyte Layer
     
     Bone (Muscoskeletal System)
             Bone Marrow
    IL18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.83077
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL18 (see all 18): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Inflammasomes in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Th17 Response in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL18 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il181 , 5 interleukin 181, 5 75.53(n)1
    65.96(a)1
      9 (27.75 cM)5
    161731  NM_008360.11  NP_032386.11 
     505752735 
    chicken
    (Gallus gallus)
    Aves IL186
    Gallus gallus interleukin 18 (interferon-gamma-ind...
    33(a)
    1 ↔ 1
    24(6163150-6165998) ENSGALG00000007874
    lizard
    (Anolis carolinensis)
    Reptilia IL186
    interleukin 18 (interferon-gamma-inducing factor)
    29(a)
    1 ↔ 1
    GL343973.1(59639-61532)


    ENSEMBL Gene Tree for IL18 (if available)
    TreeFam Gene Tree for IL18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL18 gene
    1 SIMAP similar gene for IL18 using alignment to 2 protein entries:     IL18_HUMAN (see all proteins):
    IL-18

    IL18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL18 (see all 506)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1114800831,2
    C,F--111877238(+) TATCAA/GTATCT 2 -- ds50012Minor allele frequency- G:0.09CSA WA 120
    rs1889633691,2
    --111877242(+) AATATA/CTTTTG 2 -- ds50010--------
    rs57442941,2
    C,F--111877308(-) TAATTG/AGCATA 2 -- ds50014Minor allele frequency- A:0.04NA EU WA 212
    rs49371001,2
    C,F,A--111877341(+) TATGAA/GTTTTT 2 -- ds500112Minor allele frequency- G:0.46NA EU NS WA EA 504
    rs1502894941,2
    C--111877398(+) AAGTC-/TGTT  
            
    TGTTT
    2 -- ds50010--------
    rs557820761,2
    C--111877495(+) ATAATC/TTCATA 2 -- ds50010--------
    rs1930685471,2
    --111877522(+) AAATTA/CAGACA 2 -- ds50010--------
    rs3607271,2
    C,F,A--111877644(-) GAGGTG/AGAGGT 2 -- ut31 ese312Minor allele frequency- A:0.03NA EU WA CSA EA 227
    rs1853096901,2
    --111877686(+) CTTGAA/GTAGCT 2 -- ut310--------
    rs57442921,2
    C,F--111877691(-) ATCCCA/GGCTAC 2 -- ut31 ese311Minor allele frequency- G:0.23NA EU MN NS 446

    HapMap Linkage Disequilibrium report for IL18 (112013974 - 112034840 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IL18:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745077CNV Deletion23290073
    nsv519192CNV Gain19592680

    Human Gene Mutation Database (HGMD): IL18
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL18
    DNA2.0 Custom Variant and Variant Library Synthesis for IL18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600953    OMIM disorders: --

    Selected diseases for IL18 (see all 259):    
    About MalaCards
    adult-onset still's disease    mercury poisoning    uremic pruritus    miliary tuberculosis
    pleural tuberculosis    leptin deficiency    stachybotrys chartarum    schnitzler syndrome
    molluscum contagiosum    spastic cerebral palsy    acute graft versus host disease    large granular lymphocyte leukemia
    t-cell large granular lymphocyte leukemia    chronic infantile neurological cutaneous articular syndrome    periventricular leukomalacia    rasmussen encephalitis
    lupus nephritis    eosinophilic pneumonia    pleurisy    plasmodium falciparum malaria

    3 diseases from the University of Copenhagen DISEASES database for IL18:
    Arthritis     Atherosclerosis     Hypersensitivity reaction type II disease

    IL18 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for IL18 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 74.3 262 12798479 (4), 17100768 (3), 12492197 (3), 12010883 (3) (see all 99)
    stills disease adult-onset 73.5 24 11263769 (2), 18050226 (2), 15934126 (2), 16563174 (1) (see all 16)
    necrosis 71.5 290 11923692 (2), 17189537 (2), 17608757 (2), 20096599 (2) (see all 99)
    rheumatoid arthritis 63.9 123 15320916 (3), 15172050 (2), 14872485 (2), 16368150 (2) (see all 73)
    autoimmune diseases 55.2 53 11315928 (4), 11641240 (3), 11673550 (3), 17143689 (2) (see all 30)
    tumors 52.2 381 12918059 (7), 17016692 (5), 15004655 (4), 10371355 (4) (see all 99)
    dermatitis atopic 51.8 43 18094564 (5), 17323858 (3), 11600194 (2), 11490156 (2) (see all 26)
    atherosclerosis 46.6 69 18590113 (4), 20350254 (3), 15860738 (3), 17626902 (3) (see all 33)
    lupus erythematosus systemic 46.3 33 18250135 (2), 19758166 (2), 19605669 (2), 17361200 (2) (see all 21)
    pleurisy tuberculous 43.9 3 16256041 (1), 12472673 (1), 18663530 (1)

    Genetic Association Database (GAD): IL18
    Human Genome Epidemiology (HuGE) Navigator: IL18 (224 documents)

    Export disorders for IL18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL18 gene, integrated from 10 sources (see all 2023):
    (articles sorted by number of sources associating them with IL18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. [Correlations between serum interleukin-18 (IL-18) level, IL-18 gene promoter polymorphisms and the development of sepsis in children]. (PubMed id 20441695)1, 4, 9 Cai L.L....Zeng X. (Zhonghua Er Ke Za Zhi 2010)
    2. IL18 haplotypes are associated with serum IL-18 concentrations in a population-based study and a cohort of individuals with premature coronary heart disease. (PubMed id 17962365)1, 4, 9 Thompson S.R....Humphries S.E. (Clin. Chem. 2007)
    3. [Correlation of serum IL-18 level and IL-18 gene promoter polymorphisms to the risk of cervical cancer]. (PubMed id 18504197)1, 4, 9 Qi T....Bao J. (Nan Fang Yi Ke Da Xue Xue Bao 2008)
    4. Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease. (PubMed id 16043644)1, 4, 9 Tiret L....Blankenberg S. (Circulation 2005)
    5. Levels of interleukin-18 are markedly increased in Helicobacter pylori-infected gastric mucosa among patients with specific IL18 genotypes. (PubMed id 18442334)1, 4, 9 Sakai K....Yamaoka Y. (J. Infect. Dis. 2008)
    6. Interleukin-10 and interleukin-18 promoter polymorphisms in an Italian cohort of patients with undifferentiated carcinoma of nasopharyngeal type. (PubMed id 16059673)1, 4, 9 Pratesi C....De Paoli P. (Cancer Immunol. Immunother. 2006)
    7. Roles of functional polymorphisms in the interleukin-18 gene promoter in sarcoidosis. (PubMed id 16053025)1, 4, 9 Zhou Y....Nishimura M. (Sarcoidosis Vasc Diffuse Lung Dis 2005)
    8. Association of polymorphisms of interleukin-18 gene promoter region with chronic hepatitis B in Chinese Han population. (PubMed id 15786533)1, 4, 9 Zhang P.A....Yang X.S. (World J. Gastroenterol. 2005)
    9. Interleukin-18 gene polymorphism and markers of subclinical atherosclerosis. The Cardiovascular Risk in Young Finns Study. (PubMed id 20350254)1, 4, 9 Hernesniemi J.A....LehtimAoki T. (Ann. Med. 2010)
    10. Association of IL-18 gene polymorphism (-137C) with arthritis manifestations in SLE: combined effect with IFN gamma gene polymorphism (+874A). (PubMed id 19031096)1, 4, 9 Hirankarn N....Avihingsanon Y. (Clin. Rheumatol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3606 HGNC: 5986 AceView: IL18 Ensembl:ENSG00000150782 euGenes: HUgn3606
    ECgene: IL18 Kegg: 3606 H-InvDB: IL18

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL18 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL18 gene:
    Search GeneIP for patents involving IL18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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