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Aliases for IL18 Gene

Aliases for IL18 Gene

  • Interleukin 18 2 3
  • Interleukin 18 (Interferon-Gamma-Inducing Factor) 2 3
  • IFN-Gamma-Inducing Factor 3 4
  • Interleukin-1 Gamma 3 4
  • Iboctadekin 3 4
  • IL-1 Gamma 3 4
  • IL-18 3 4
  • IL1F4 3 4
  • IGIF 3 4
  • Interferon-Gamma-Inducing Factor 2
  • Interferon Gamma-Inducing Factor 4
  • IL-1g 3

External Ids for IL18 Gene

Previous GeneCards Identifiers for IL18 Gene

  • GC11M114366
  • GC11M113526
  • GC11M112047
  • GC11M111551
  • GC11M111519
  • GC11M107938
  • GC11M112013

Summaries for IL18 Gene

Entrez Gene Summary for IL18 Gene

  • The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

GeneCards Summary for IL18 Gene

IL18 (Interleukin 18) is a Protein Coding gene. Diseases associated with IL18 include adult-onset still's disease and uremic pruritus. Among its related pathways are Immune System and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot for IL18 Gene

  • Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells

Gene Wiki entry for IL18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL18 Gene

Genomics for IL18 Gene

Regulatory Elements for IL18 Gene

Genomic Location for IL18 Gene

Chromosome:
11
Start:
112,143,251 bp from pter
End:
112,164,117 bp from pter
Size:
20,867 bases
Orientation:
Minus strand

Genomic View for IL18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL18 Gene

Proteins for IL18 Gene

  • Protein details for IL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14116-IL18_HUMAN
    Recommended name:
    Interleukin-18
    Protein Accession:
    Q14116
    Secondary Accessions:
    • O75599
    • Q6FGY3
    • Q6WWJ7

    Protein attributes for IL18 Gene

    Size:
    193 amino acids
    Molecular mass:
    22326 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL18 Gene

    Alternative splice isoforms for IL18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL18 Gene

Proteomics data for IL18 Gene at MOPED

Post-translational modifications for IL18 Gene

  • The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL18 Gene

Antibody Products

No data available for DME Specific Peptides for IL18 Gene

Domains & Families for IL18 Gene

Gene Families for IL18 Gene

Protein Domains for IL18 Gene

Suggested Antigen Peptide Sequences for IL18 Gene

Graphical View of Domain Structure for InterPro Entry

Q14116

UniProtKB/Swiss-Prot:

IL18_HUMAN :
  • Belongs to the IL-1 family.
Family:
  • Belongs to the IL-1 family.
genes like me logo Genes that share domains with IL18: view

Function for IL18 Gene

Molecular function for IL18 Gene

GENATLAS Biochemistry:
interleukin 18,interferon-gamma inducing factor,involved in Th1-mediated cellular immunity
UniProtKB/Swiss-Prot Function:
Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells

Gene Ontology (GO) - Molecular Function for IL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity TAS 11598150
GO:0005515 protein binding IPI 25261253
genes like me logo Genes that share ontologies with IL18: view
genes like me logo Genes that share phenotypes with IL18: view

Animal Models for IL18 Gene

MGI Knock Outs for IL18:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL18

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL18 Gene

Localization for IL18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL18 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL18 Gene COMPARTMENTS Subcellular localization image for IL18 gene
Compartment Confidence
extracellular 5
cytosol 4
golgi apparatus 2
lysosome 2
nucleus 2
plasma membrane 2
vacuole 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 11598150
GO:0005615 extracellular space IBA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with IL18: view

Pathways & Interactions for IL18 Gene

genes like me logo Genes that share pathways with IL18: view

PCR Array Products

SIGNOR curated interactions for IL18 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IMP 21147091
GO:0001525 angiogenesis IDA 11466388
GO:0006954 inflammatory response IDA 21147091
GO:0006955 immune response TAS 8999896
GO:0007267 cell-cell signaling TAS 9792649
genes like me logo Genes that share ontologies with IL18: view

Drugs & Compounds for IL18 Gene

(74) Drugs for IL18 Gene - From: NovoSeek and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tacrolimus Approved, Investigational Pharma 992
Alendronate Approved Pharma Inhibition, Inhibitor Bone resorption inhibitor, Osteoclast function modifiers (important in bone metastasis) 153
Anakinra Approved Pharma IL-1 receptor antagonist 0
Aspirin Approved Pharma Channel blocker 971
Atorvastatin Approved Pharma Competitive, Inhibitor 690

(62) Additional Compounds for IL18 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1,25 DIHYDROXY VITAMIN D3
1-chloro-24-dinitrobenzene
3-hydroxy-3-methylglutaryl-coa
  • (S)-3-hydroxy-3-methylglutaryl-CoA
  • (S)-3-hydroxy-3-methylglutaryl-Coenzyme A
  • 3-Hydroxy-3-methyl-Glutaryl-CoA
  • 3-Hydroxy-3-methyl-Glutaryl-Coenzyme A
  • 3-Hydroxy-3-methylglutaryl-CoA
1553-55-5
5fluorouracil
adenylate
genes like me logo Genes that share compounds with IL18: view

Transcripts for IL18 Gene

Unigene Clusters for IL18 Gene

Interleukin 18 (interferon-gamma-inducing factor):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL18

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL18 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: - - - -
SP2: - -
SP3: -
SP4:
SP5:

Relevant External Links for IL18 Gene

GeneLoc Exon Structure for
IL18
ECgene alternative splicing isoforms for
IL18

Expression for IL18 Gene

mRNA expression in normal human tissues for IL18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL18 Gene

This gene is overexpressed in Esophagus - Mucosa (x7.1), Skin - Sun Exposed (Lower leg) (x6.4), Skin - Not Sun Exposed (Suprapubic) (x6.0), and Vagina (x4.5).

Protein differential expression in normal tissues from HIPED for IL18 Gene

This gene is overexpressed in Lymph node (11.0), Oral epithelium (10.0), and Heart (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IL18 Gene



SOURCE GeneReport for Unigene cluster for IL18 Gene Hs.83077

genes like me logo Genes that share expression patterns with IL18: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IL18 Gene

Orthologs for IL18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL18 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL18 35
  • 86.36 (n)
  • 77.72 (a)
IL18 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL18 35
  • 84.55 (n)
  • 73.96 (a)
IL18 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il18 35
  • 75.53 (n)
  • 65.96 (a)
Il18 16
Il18 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL18 35
  • 99.48 (n)
  • 100 (a)
IL18 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il18 35
  • 74.39 (n)
  • 63.68 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia IL18 36
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL18 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL18 36
  • 29 (a)
OneToOne
Species with no ortholog for IL18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL18 Gene

ENSEMBL:
Gene Tree for IL18 (if available)
TreeFam:
Gene Tree for IL18 (if available)

Paralogs for IL18 Gene

(1) SIMAP similar genes for IL18 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IL18: view

No data available for Paralogs for IL18 Gene

Variants for IL18 Gene

Sequence variations from dbSNP and Humsavar for IL18 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs183116 -- 112,149,178(+) tccca(C/G)ctact intron-variant
rs184862 -- 112,149,172(+) ctgta(A/G)tccca intron-variant
rs187238 -- 112,164,265(-) GAAAA(C/G)ATTTC upstream-variant-2KB
rs189667 -- 112,162,881(+) TGGCT(A/G)TCCTG intron-variant
rs191710 -- 112,149,190(+) gggag(A/G)ctgag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL18 Gene

Variant ID Type Subtype PubMed ID
esv2745077 CNV Deletion 23290073
nsv519192 CNV Gain 19592680

Variation tolerance for IL18 Gene

Residual Variation Intolerance Score: 68.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL18 Gene

HapMap Linkage Disequilibrium report
IL18
Human Gene Mutation Database (HGMD)
IL18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL18 Gene

Disorders for IL18 Gene

MalaCards: The human disease database

(61) MalaCards diseases for IL18 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
adult-onset still's disease
  • adult-onset still disease
uremic pruritus
mercury poisoning
  • mercury toxicity
pleural tuberculosis
  • tuberculosis of pleura
acute cystitis
  • urinary tract infection
- elite association
Search IL18 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL18

Genetic Association Database (GAD)
IL18
Human Genome Epidemiology (HuGE) Navigator
IL18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL18
genes like me logo Genes that share disorders with IL18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL18 Gene

Publications for IL18 Gene

  1. Nail antioxidant trace elements are inversely associated with inflammatory markers in healthy young adults. (PMID: 19582378) Puchau B. … MartA-nez J.A. (Biol Trace Elem Res 2010) 23 67
  2. IL-18 and urinary NGAL predict dialysis and graft recovery after kidney transplantation. (PMID: 19762491) Hall I.E. … Parikh C.R. (J. Am. Soc. Nephrol. 2010) 23 67
  3. IL-18 downregulates collagen production in human dermal fibroblasts via the ERK pathway. (PMID: 19865096) Kim H.J. … Park H.J. (J. Invest. Dermatol. 2010) 23 67
  4. Fetuin-A and interleukin-18 levels in ankylosing spondylitis. (PMID: 20374388) Sari I. … Akkoc N. (Int J Rheum Dis 2010) 23 67
  5. [Expressions of interleukin 18 and prostaglandin E2 and their correlation in the synoviocytes of patients with osteoarthritis]. (PMID: 20423837) Wang F.L. … Zhang Z.F. (Nan Fang Yi Ke Da Xue Xue Bao 2010) 23 67

Products for IL18 Gene

Sources for IL18 Gene

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