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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL18 Gene

protein-coding GIFtS: 69
GCID: GC11M112013

interleukin 18 (interferon-gamma-inducing factor)

Explore 267 diseases affiliated with
IL18 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin 18 (Interferon-Gamma-Inducing Factor)¹ ²		IFN-Gamma-Inducing Factor² ³
IGIF¹ ² ³ ⁵		IL-1 Gamma² ³
IL-18¹ ² ³		Iboctadekin³
IL1F4¹ ² ³		Interleukin-18¹
IL-1g¹ ²		Iboctadekin³
Interleukin-1 Gamma² ³		Interferon Gamma-Inducing Factor³

External Ids:	HGNC: 5986¹	Entrez Gene: 3606²	Ensembl: ENSG00000150782⁷	OMIM: 600953⁵	UniProtKB: Q14116³

Export aliases for IL18 gene to outside databases

Previous GC identifers: GC11M114366 GC11M113526 GC11M112047 GC11M111551 GC11M111519 GC11M107938

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL18:

The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen

cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants

encoding different isoforms have been found for this gene.(provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: IL18_HUMAN, Q14116

Function: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper

type I cells

Gene Wiki entry for IL18 (Interleukin 18)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL18 gene promoter:
TBP AP-1 ATF-2 NF-kappaB NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL18 promoter sequence

Search SABiosciences Chromatin IP Primers for IL18

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL18

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.2-q22.3 Ensembl cytogenetic band: 11q23.1 HGNC cytogenetic band: 11q22.2-q22.3

IL18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL18 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M112013: view genomic region (about GC identifiers)

Start:	112,013,974 bp from pter	End:	112,034,840 bp from pter
Size:	20,867 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL18_HUMAN, Q14116 (See protein sequence)

Recommended Name: Interleukin-18 precursor

Size: 193 amino acids; 22326 Da

Subcellular location: Secreted

5 PDB 3D structures from and Proteopedia for IL18:

1J0S (3D)

2VXT (3D)

3F62 (3D)

4EEE (3D)

4EKX (3D)

Secondary accessions: O75599 Q6FGY3 Q6WWJ7

Alternative splicing: 2 isoforms: Q14116-1 Q14116-2 (Expressed in ovarian carcinoma but undetectable in normal ovarian epithelial cells. Resistant to proteolytic activation by caspase-1 and -4)

Explore the universe of human proteins at neXtProt for IL18: NX_Q14116

Post-translational modifications:

The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14116

IL18 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001230140.1 NP_001553.1

ENSEMBL proteins:

ENSP00000280357 ENSP00000434561 ENSP00000434161

Reactome Protein details: Q14116
Human Recombinant Protein Products for IL18:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for IL18 (IL-18/IL-1F4)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: IL18 OriGene Protein Over-expression Lysate: IL18 OriGene Custom Protein Services for IL18
	GenScript Custom Purified and Recombinant Proteins Services for IL18
	Novus Biologicals IL18 Proteins Novus Biologicals IL18 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IL18
	Uscn Proteins for IL18

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--
GO:0016324	apical plasma membrane	IEA	--

IL18 for ontologies About GeneDecksing

IL18 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IL18
	R&D Systems Antibodies for IL18 (IL-18/IL-1F4)
	OriGene Antibodies: IL18 OriGene Custom Antibody Services for IL18
	GenScript Custom Superior Antibodies Services for IL18
	Novus Biologicals IL18 Antibody
	Abcam antibodies for IL18
	Uscn Antibodies for IL18
	ThermoFisher Antibody for IL18

Assay Products for IL18:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for IL18 (IL-18/IL-1F4)
	GenScript Custom Assay Services for IL18
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IL18

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL18 for domains About GeneDecksing

3 InterPro domains/families:

IPR015529 Interleukin_18

IPR008996 Cytokine_IL1-like

IPR000975 Interleukin_1

Graphical View of Domain Structure for InterPro Entry Q14116

ProtoNet protein and cluster: Q14116

1 Blocks protein family: IPB000975 Interleukin-1 precursor family signature

UniProtKB/Swiss-Prot: IL18_HUMAN, Q14116

Similarity: Belongs to the IL-1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IL18_HUMAN, Q14116

Function: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper

type I cells

Genatlas biochemistry entry for IL18:

interleukin 18,interferon-gamma inducing factor,involved in Th1-mediated cellular immunity

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	TAS	11598150
GO:0005515	protein binding	--	--

IL18 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for IL18:

Increased gamma-H2AX phosphory

12 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Il18):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
growth/size	hematopoietic system	homeostasis/metabolism	immune system	muscle
nervous system	vision/eye

IL18 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for IL18: Il18^tm1Khe Il18^tm1Aki

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IL18

miRNA Products:		miRTarBase miRNAs that target IL18: hsa-mir-346 (MIRT004304)

		OriGene 3'-UTR Clone: IL18 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL18
		1 QIAGEN miScript miRNA Assays for microRNA that regulate IL18:
		hsa-miR-590-3p
		SwitchGear 3'UTR luciferase reporter plasmid: IL18 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL18 (see all 7) OriGene shRNA RFP: IL18 OriGene siRNA: IL18
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL18
		Sirion Biotech Custom design and validation of potent shRNA sequences against IL18

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for IL18
			Sirion Biotech Customized adenovirus for overexpression of IL18 Sirion Biotech Customized adenovirus for potent knockdown of IL18

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL18 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL18 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL18 (NM_001562)
		Sino Biological Human cDNA Clone for IL18
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL18
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL18

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL18
		Search LifeMap BioReagents cell lines for IL18
		Sirion Biotech Customized stable knockdown cell line services for IL18 Sirion Biotech Customized inducible knockdown cell line services for IL18 Sirion Biotech Customized stable overexpressing cell line services for IL18 Sirion Biotech Customized inducible overexpressing cell line services for IL18

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL18

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/25 super-pathways (see all 25) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/12 pathways (see all 12)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

TGF-Beta Pathway

TGF-Beta Pathway	1.00	Regulation of eIF4 and p70S6K	0.43
MAPK Family Pathway	0.60	SOCS Pathway	0.29
JAK-STAT Pathway	0.57

Immune response IL-12-induced IFN-gamma production

	Immune response IL-12-induced IFN-gamma production	1.00			IL12-mediated signaling events	0.33
	Immune response_IL-12-induced IFN-gamma production	0.88

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for IL18

Immune response IL-12-induced IFN-gamma production

3 R&D Systems Pathways for IL18

	Inflammasome Activation Pathways
	Th1 Differentiation
	Toll-Like receptor Signaling Pathways

5/27 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL18 (see all 27)

	THC Differentiation Pathway
	MSP-RON Signaling
	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C

1 GeneGo (Thomson Reuters) Pathway for IL18

Immune response IL-12-induced IFN-gamma production

5/6 BioSystems Pathways for IL18 (see all 6)

	NOD pathway
	IL23-mediated signaling events
	IL27-mediated signaling events
	IL12 signaling mediated by STAT4
	IL12-mediated signaling events

5 Reactome Pathways for IL18

	Interleukin-1 processing
	Cytokine Signaling in Immune system
	Interleukin-1 family are secreted
	Signaling by Interleukins
	Immune System

5/8 Kegg Pathways (Kegg details for IL18) (see all 8):

	Cytokine-cytokine receptor interaction
	NOD-like receptor signaling pathway
	Cytosolic DNA-sensing pathway
	African trypanosomiasis
	Malaria

IL18 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL18

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/21 Interacting proteins for IL18 (Q14116³ ENSP00000280357⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CASP4	P49662³, ENSP00000388566⁴	I2D: score=4 STRING: ENSP00000388566
CASP3	P42574³, ENSP00000311032⁴	I2D: score=3 STRING: ENSP00000311032
CASP1	P29466³, ENSP00000410076⁴	I2D: score=4 STRING: ENSP00000410076
IL18BP	O95998³, ENSP00000260049⁴	I2D: score=2 STRING: ENSP00000260049
IL18R1	Q13478³, ENSP00000233957⁴	I2D: score=3 STRING: ENSP00000233957

About this table

Gene Ontology (GO): 5/53 biological process terms (GO ID links to tree view) (see all 53): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	IMP	--
GO:0001525	angiogenesis	IDA	11466388
GO:0001649	osteoblast differentiation	IEA	--
GO:0001666	response to hypoxia	IEA	--
GO:0006954	inflammatory response	IDA	--

IL18 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL18 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL18
10/136 Novoseek chemical compound relationships for IL18 gene (see all 136) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
il-12	69.2	23	15122806 (3), 18765427 (2), 12002384 (2), 17324967 (2) (see all 16)
lfa703	66.9	7	15618295 (6), 17482516 (1)
il 10	60.7	15	17324967 (2), 20083555 (2), 15281432 (1), 16759385 (1) (see all 12)
rantes	57.3	44	19323903 (4), 15645140 (3), 17623049 (2), 15975968 (2) (see all 30)
pralnacasan	55.1	1	14610233 (1)
ccl3	47.2	1	17170049 (1)
anakinra	46.3	1	17583775 (1)
imidazoquinoline	44.6	2	16407888 (1), 15544517 (1)
ifn-alpha	40.3	6	18765427 (3), 12220554 (1), 15663652 (1), 14978071 (1)
4-methylhistamine	36.2	1	10843724 (1)

Search CenterWatch for drugs/clinical trials and news about IL18

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL18 gene (2 alternative transcripts):

NM_001243211.1 NM_001562.3

Unigene Cluster for IL18:

Interleukin 18 (interferon-gamma-inducing factor)

Hs.83077 [show with all ESTs]

Unigene Representative Sequence: NM_001562

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000280357(uc001pnb.2 uc009yym.2) ENST00000524595 ENST00000525547(uc001pna.2)

ENST00000528832 ENST00000533858 ENST00000534225

miRNA Products:		OriGene 3'-UTR Clone: IL18 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL18
		1 QIAGEN miScript miRNA Assays for microRNA that regulate IL18:
		hsa-miR-590-3p
		SwitchGear 3'UTR luciferase reporter plasmid: IL18 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL18 (see all 7) OriGene shRNA RFP: IL18 OriGene siRNA: IL18
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL18
		Sirion Biotech Custom design and validation of potent shRNA sequences against IL18

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL18 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL18 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL18 (NM_001562)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL18
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL18

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL18 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL18
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL18
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL18

Additional cDNA sequence:

AF077611.1 AF380360.1 AK311301.1 AY044641.1 AY266351.1 BC007007.1 BC007461.1 CR541973.1

CR542001.1 D49950.1 U90434.1

8 DOTS entries:

DT.203558 DT.120733823 DT.120733704 DT.100718627 DT.40246703 DT.95094414 DT.91740655 DT.97788905

24/76 AceView cDNA sequences (see all 76):

BQ082738 BM849891 NM_001562 CR542001 U90434 BG751576 BM849862 BF590479

AI394321 D49950 CR541973 BG681242 AY044641 BQ427550 AY266351 BM856014

BG500265 BM926493 BU959596 AF077611 BU633686 BM449838 BM767222 BF968230

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for IL18 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6	^	7
SP1:					-				-		-		-
SP2:					-				-
SP3:					-
SP4:
SP5:

ECgene alternative splicing isoforms for IL18

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTCAATCC

About this image

IL18 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Eye

Inner Nuclear Layer

Mature Rod Bipolar Cells

Bipolar, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IL18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL18

SOURCE GeneReport for Unigene cluster: Hs.83077

SABiosciences Expression via Pathway-Focused PCR Arrays including IL18 (see all 18):

Antiviral Response in human mouse rat

Multiple Sclerosis in human mouse rat

Inflammasomes in human mouse rat

T-cell & B-cell Activation in human mouse rat

Th17 Response in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL18 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL18
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL18
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL18

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL18

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL18 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Il18^{1 , 5}	interleukin 18^{1, 5}	75.77(n)¹ 66.12(a)¹		9 (27.75 cM)⁵ 16173¹ NM_008360.1¹ NP_032386.1¹ 50575273⁵
chicken (Gallus gallus)	Aves	Q6IT44_CHICK⁶	interleukin 18	33(a)	1 ↔ 1	24(6291983-6295250)
lizard (Anolis carolinensis)	Reptilia	IL18⁶	--	27(a)	1 ↔ 1	GL343973.1(59639-61532)

ENSEMBL Gene Tree for IL18 (if available)
TreeFam Gene Tree for IL18 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111480083^1,2		--	112013683(+)	`TATCAA/GTATCT`	2	--	ds500¹		2		CSA WA	120
rs188963369^1,2		--	112013687(+)	`AATATA/CTTTTG`	2	--	ds500¹		0	--	--	--	--
rs5744294^1,2	C,F	--	112013753(-)	`TAATTG/AGCATA`	2	--	ds500¹		4		NA EU WA	212
rs4937100^1,2	C,F,A	--	112013786(+)	`TATGAA/GTTTTT`	2	--	ds500¹		12		NA EU NS WA EA	504
rs150289494^1,2	C	--	112013843(+)	`AAGTC-/TGTT TGTTT`	2	--	ds500¹		0	--	--	--	--
rs45565434^1,2	C,F	--	112013845(+)	`GTTTGTTTG/- CTTTT`	2	--	ds500¹		1		NS	40
rs55782076^1,2	C	--	112013940(+)	`ATAATC/TTCATA`	2	--	ds500¹		0	--	--	--	--
rs193068547^1,2		--	112013967(+)	`AAATTA/CAGACA`	2	--	ds500¹		0	--	--	--	--
rs360727^1,2	C,F,A	--	112014089(-)	`GAGGTG/AGAGGT`	2	--	ut3¹ ese³		12		NA EU WA CSA EA	227
rs185309690^1,2		--	112014131(+)	`CTTGAA/GTAGCT`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IL18 (112013974 - 112034840 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IL18: --
Human Gene Mutation Database (HGMD): IL18

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL18

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL18 for disorders           About GeneDecksing

OMIM gene information: 600953    OMIM disorders: --

20/267 diseases for IL18 (see all 267):    About MalaCards

graft versus host disease chronic infantile neurological cutaneous articular syndrome molluscum contagiosum large granular lymphocyte leukemia

adult-onset still's disease relapsing-remitting multiple sclerosis stachybotrys chartarum hypersensitivity reaction type ii disease

acute graft versus host disease mercury poisoning t-cell large granular lymphocyte leukemia age related macular degeneration

scrub typhus prader-willi syndrome periventricular leukomalacia nonspecific interstitial pneumonia

arterial occlusive disease lupus erythematosus mycobacterial infection peripheral arterial occlusive disease

11 diseases from the University of Copenhagen DISEASES database for IL18:

Arthritis Hypersensitivity reaction type II disease Inflammatory bowel disease Atopic dermatitis

Connective tissue disease Atherosclerosis Asthma Cancer

Tuberculosis Diabetes mellitus Kidney disease

10/95 Novoseek disease relationships for IL18 gene (see all 95) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	74.3	262	12798479 (4), 17100768 (3), 12492197 (3), 12010883 (3) (see all 99)
stills disease adult-onset	73.5	24	11263769 (2), 18050226 (2), 15934126 (2), 16563174 (1) (see all 16)
necrosis	71.5	290	11923692 (2), 17189537 (2), 17608757 (2), 20096599 (2) (see all 99)
rheumatoid arthritis	63.9	123	15320916 (3), 15172050 (2), 14872485 (2), 16368150 (2) (see all 73)
autoimmune diseases	55.2	53	11315928 (4), 11641240 (3), 11673550 (3), 17143689 (2) (see all 30)
tumors	52.2	381	12918059 (7), 17016692 (5), 15004655 (4), 10371355 (4) (see all 99)
dermatitis atopic	51.8	43	18094564 (5), 17323858 (3), 11600194 (2), 11490156 (2) (see all 26)
atherosclerosis	46.6	69	18590113 (4), 20350254 (3), 15860738 (3), 17626902 (3) (see all 33)
lupus erythematosus systemic	46.3	33	18250135 (2), 19758166 (2), 19605669 (2), 17361200 (2) (see all 21)
pleurisy tuberculous	43.9	3	16256041 (1), 12472673 (1), 18663530 (1)

Genetic Association Database (GAD): IL18
Human Genome Epidemiology (HuGE) Navigator: IL18 (224 documents)

Export disorders for IL18 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IL18 gene, integrated from 9 sources (see all 1954):
(articles sorted by number of sources associating them with IL18)

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Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease. (PubMed id 16043644)^{1, 4, 9} Tiret L....Blankenberg S. (2005)
Interleukin-10 and interleukin-18 promoter polymorphisms in an Italian cohort of patients with undifferentiated carcinoma of nasopharyngeal type. (PubMed id 16059673)^{1, 4, 9} Pratesi C....De Paoli P. (2006)
Roles of functional polymorphisms in the interleukin-18 gene promoter in sarcoidosis. (PubMed id 16053025)^{1, 4, 9} Zhou Y....Nishimura M. (2005)
Association of polymorphisms of interleukin-18 gene promoter region with chronic hepatitis B in Chinese Han population. (PubMed id 15786533)^{1, 4, 9} Zhang P.A....Yang X.S. (2005)
Genetic predisposition to latex allergy: role of interleukin 13 and interleukin 18. (PubMed id 15731584)^{1, 4, 9} Brown R.H....Kleeberger S.R. (2005)
Association study of polymorphisms within interleukin-18 in juvenile idiopathic arthritis and bronchial asthma. (PubMed id 15230817)^{1, 4, 9} Heinzmann A....Deichmann K.A. (2004)
Polymorphisms of interleukin (IL)-1alpha, IL-1beta, IL-6, IL-10, and IL-18 and the risk of ovarian cancer. (PubMed id 15581980)^{1, 4, 9} Bushley A.W....Goodman M.T. (2004)
Association between interleukin-18 gene polymorphism 105A/C and asthma. (PubMed id 12911784)^{1, 4, 9} Higa S....Tanaka T. (2003)
IL-18 promoter polymorphisms correlate with the development of post-injury sepsis. (PubMed id 12947340)^{1, 4, 9} Stassen N.A....Polk H.C. (2003)
[Relationship of interleukin-18 gene promoter polymorphisms with chronic hepatitis B in Chinese Han population] (PubMed id 16215941)^{1, 4, 9} Zhang P.A....Yang X.S. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3606	HGNC: 5986	AceView: IL18	Ensembl:ENSG00000150782	euGenes: HUgn3606
ECgene: IL18	Kegg: 3606	H-InvDB: IL18

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IL18	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL18	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Interleukin_1

Intellectual Property for IL18 gene
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Patent Information for IL18 gene:
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IL18 Gene

interleukin 18 (interferon-gamma-inducing factor)

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CINCA SYNDROME
Nephritis
Genetic Susceptibility
sepsis
Molluscum Contagiosum
Dermatitis Atopic
Hypersensitivity Contact
Colitis Ulcerative
insulin sensitivity
Skin Diseases
Atherosclerosis
Rhinitis Allergic Seasonal
Rheumatic Diseases
Asthma
ACUTE EOSINOPHILIC PNEUMONIA
Allergic rhinitis
Diabetes Mellitus Insulin-Dependent
HEPATITIS FULMINANT
Coronary Atherosclerosis
Periodontal Diseases
Hepatitis B Chronic
RENAL DISEASE
Bronchoalveolar Lavage Fluid
acute pancreatitis
Sarcoidosis Pulmonary
Multiple Sclerosis
Inflammation
Diabetic Nephropathies
Malaria Falciparum
Chronic arthritis
Tuberculosis
Hepatitis
immunodeficiency
Psoriasis
Sarcoidosis
Lupus Erythematosus
Rheumatoid Arthritis
Tumors
Cardiovascular Diseases
Pneumonitis Hypersensitivity
Hepatitis B Acute
Multiple Sclerosis Relapsing-Remitting
Autoimmunity
Necrosis
Asthma allergic
Renal Failure Acute
Melanoma B16
virus infection
Preeclampsia
Stills Disease Adult-Onset
Coronary Heart Disease
Hepatitis C
FIBROSIS IDIOPATHIC PULMONARY
Colitis
Leukemia Lymphocytic Large Granular
Autoimmune Diseases
Lyme Neuroborreliosis
Tuberculosis Pulmonary
Salmonella infections
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atopy
mycobacterial infection
atherosclerotic plaque
Systemic Inflammatory Response Syndrome
Bacterial Infections
Osteoarthritis
Infectious disease
Miscarriage Recurrent
Purpura Thrombocytopenic Idiopathic
Tumor Escape
Shock Endotoxic
Lymphopenia
Acute graft-versus-host disease
Inflammatory Bowel Diseases
Multiple Organ Failure
Coronary Artery Disease
Ectromelia
Response Acute Phase
Insulin Resistance
Eosinophilia
Liver Dysfunction
BEHCET DISEASE
OBESITY
Lipodystrophy
autoimmune thyroid disease
SKIN LESION
Hepatitis C Chronic
Lymphohistiocytosis Hemophagocytic
Granuloma
Lupus Nephritis
Pleurisy Tuberculous
Graft-Versus-Host Disease
Synovitis
Arthritis
Lupus Erythematosus Systemic

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IL18 Gene

interleukin 18 (interferon-gamma-inducing factor)

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