IL17REL Gene
protein-coding GIFtS: 36
GCID: GC22M050432
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interleukin 17 receptor E-like
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Aliases
for IL17REL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interleukin 17 Receptor E-Like1 2 | | IL-17RE-Like1 | | IL-17 Receptor E-Like2 3 | | FLJ419931 | | Putative Interleukin-17 Receptor E-Like2 |
Export aliases for IL17REL gene to outside databasesPrevious GC identifers: GC22M048775 GC22M033332 |
Summaries
for IL17REL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for IL17REL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011526.7
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IL17REL gene promoter:
RP58 GCNF Lmo2 AREB6 PPAR-alpha PPAR-gamma1 GCNF-1 PPAR-gamma2 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for IL17REL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL17REL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.33 Ensembl cytogenetic band: 22q13.33 HGNC cytogenetic band: 22q13.33IL17REL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M050432: view genomic region
(about GC identifiers)
Start:
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50,432,942 bp from pter |
End:
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50,451,088 bp from pter |
Size:
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18,147 bases |
Orientation:
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minus strand |
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Proteins
for IL17REL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: I17EL_HUMAN, Q6ZVW7 (See
protein sequence)Recommended Name: Putative interleukin-17 receptor E-like Size: 336 amino acids; 37514 Da
Secondary accessions: A6NCN4 A6PVC1Explore the universe of human proteins at neXtProt for IL17REL: NX_Q6ZVW7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZVW7
IL17REL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001001694.2
ENSEMBL proteins: ENSP00000374633 ENSP00000342520
Human Recombinant Protein Products:
IL17REL Antibody Products:
Assay Products for IL17REL: |
Protein
Domains /
Families
for IL17REL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6ZVW7 |
Function
for IL17REL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL17REL
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL17REL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IL17REL (NM_001001694) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL17REL | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IL17REL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17REL |
|
Pathways & Interactions
for IL17REL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IL17REL
|
Drugs & Compounds
for IL17REL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IL17REL
Search CenterWatch for drugs/clinical trials and news about IL17REL / I17EL
|
Transcripts
for IL17REL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IL17REL gene: NM_001001694.2 Unigene Cluster for IL17REL: Interleukin 17 receptor E-like Hs.526712 [show with all ESTs]Unigene Representative Sequence: AK1239872 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000389983(uc003bje.1) ENST00000341280
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL17REL
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL17REL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IL17REL (NM_001001694) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL17REL | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IL17REL |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL17REL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IL17REL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL17REL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL17REL |
Additional cDNA sequence: AK123987.1 1 DOTS entry: DT.101966178 2 AceView cDNA sequences: NM_001001694 AK123987
GeneLoc Exon Structure
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Expression
for IL17REL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IL17REL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See IL17REL Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.526712
SABiosciences Custom PCR Arrays for IL17REL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL17REL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IL17REL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL17REL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL17REL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17REL |
Orthologs
for IL17REL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IL17REL gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for IL17REL (if available)
TreeFam Gene Tree for IL17REL (if available) |
Paralogs
for IL17REL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IL17REL gene
- IL17RC2 IL17RE2
IL17REL for paralogs About GeneDecksing
|
Genomic Variants
for IL17REL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for IL17REL (50432942 - 50451088 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IL17REL
1 Indel: 103217
Human Gene Mutation Database (HGMD): IL17REL
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL17REL |
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Disorders
/ Diseases
for IL17REL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IL17REL for disorders About GeneDecksing
OMIM gene information: 613414
OMIM disorders: --
1  disease for IL17REL: About MalaCardsulcerative colitis
Human Genome Epidemiology (HuGE) Navigator: IL17REL (1 document)
Export disorders for IL17REL gene to outside databases
|
Publications
for IL17REL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IL17REL gene integrated from 9 sources:
(articles sorted by number of sources associating them with IL17REL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Meta-analysis identifies 29 additional ulcerative col itis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1 Anderson C.A....Rioux J.D. (2011)
- Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). (PubMed id 20228798)1 Franke A....Vatn M.H. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)
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External Searches for IL17REL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing IL17REL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IL17REL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IL17REL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IL17REL | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for IL17REL gene:
Search GeneIP for patents involving IL17REL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IL17REL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IL17REL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL17REL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL17REL | | | OriGene Protein Over-expression Lysate for IL17REL | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IL17REL | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL17REL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL17REL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IL17REL | | OriGene Custom Protein Services for IL17REL | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL17REL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL17REL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL17REL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL17REL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL17REL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL17REL |
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| | | | Search Tocris compounds for IL17REL |
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 | | | IL17REL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17REL |
|  |  |  | | | | Search ThermoFisher Antibodies for IL17REL |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IL17REL |
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