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IL17REL Gene

protein-coding   GIFtS: 37
GCID: GC22M050432

Interleukin 17 Receptor E-Like

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 17 Receptor E-Like1 2
IL-17RE-like2 3
IL-17 Receptor E-Like2 3
Putative Interleukin-17 Receptor E-Like2

External Ids:    HGNC: 338081   Entrez Gene: 4009352   Ensembl: ENSG000001882637   OMIM: 6134145   UniProtKB: Q6ZVW73   

Export aliases for IL17REL gene to outside databases

Previous GC identifers: GC22M048775 GC22M033332


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IL17REL Gene:
IL17REL (interleukin 17 receptor E-like) is a protein-coding gene. An important paralog of this gene is IL17RE.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011526.8  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL17REL gene promoter:
         RP58   GCNF   Lmo2   AREB6   PPAR-alpha   PPAR-gamma1   GCNF-1   PPAR-gamma2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL17REL promoter sequence
   Search Chromatin IP Primers for IL17REL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL17REL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.33

IL17REL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL17REL gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M050432:  view genomic region     (about GC identifiers)

Start:
50,432,942 bp from pter      End:
50,451,088 bp from pter
Size:
18,147 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: I17EL_HUMAN, Q6ZVW7 (See protein sequence)
Recommended Name: Putative interleukin-17 receptor E-like  
Size: 336 amino acids; 37514 Da
Secondary accessions: A6NCN4 A6PVC1

Explore the universe of human proteins at neXtProt for IL17REL: NX_Q6ZVW7

Explore proteomics data for IL17REL at MOPED


See IL17REL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001001694.2  
ENSEMBL proteins: 
 ENSP00000374633   ENSP00000342520  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR027841 IL-17_rcpt_C/E_N

Graphical View of Domain Structure for InterPro Entry Q6ZVW7

ProtoNet protein and cluster: Q6ZVW7


Find genes that share domains with IL17REL           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for IL17REL

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus2
cytosol1
extracellular1
mitochondrion1
peroxisome1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IL17REL
Interactions:

    Search GeneGlobe Interaction Network for IL17REL

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for IL17REL (I17EL)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for IL17REL gene: 
NM_001001694.2  

Unigene Cluster for IL17REL:

Interleukin 17 receptor E-like
Hs.526712  [show with all ESTs]
Unigene Representative Sequence: AK123987
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000389983(uc003bje.1) ENST00000341280
miRNA
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Inhib. RNA
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Additional mRNA sequence: AK123987.1 

1 DOTS entry:

DT.101966178 

2 AceView cDNA sequences:

AK123987 NM_001001694 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IL17REL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IL17REL Expression
About this image

IL17REL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IL17REL Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.526712
    Custom PCR Arrays for IL17REL
Primer
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for IL17REL gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia IL17REL1 interleukin 17 receptor E-like 79.24(n)
71.17(a)
  607159  XM_005625729.1  XP_005625786.1 
chicken
(Gallus gallus)
Aves IL17REL1 interleukin 17 receptor E-like 52.71(n)
48.44(a)
  769256  XM_001232492.3  XP_001232493.3 
tropical clawed frog
(Xenopus tropicalis)
Amphibia il17rel1 interleukin 17 receptor E-like 50.24(n)
41.37(a)
  100486611  XM_002932199.2  XP_002932245.2 
zebrafish
(Danio rerio)
Actinopterygii LOC1003311951 putative interleukin-17 receptor E-like 45.96(n)
39.65(a)
  100331195  XM_002666890.2  XP_002666936.2 


ENSEMBL Gene Tree for IL17REL (if available)
TreeFam Gene Tree for IL17REL (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IL17REL gene
IL17RE2  

Find genes that share paralogs with IL17REL           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IL17REL (see all 492)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1903184191,2
--50432534(+) CCTGGG/TCGAGT 1 -- ds50010--------
rs1378411,2
C,F,A,H--50432604(+) GCCCCC/ACACTG 1 -- ds50019Minor allele frequency- A:0.20EA NS NA WA 540
rs588019581,2
C--50432744(+) GTGACACTGAC  
  CTTA
/-
GCTGA
1 -- ds50012Minor allele frequency- -:0.00NA CSA 4
rs1378421,2
C--50432745(+) GTGACA/GCTGAC 1 -- ds50010--------
rs1415706601,2
C--50432774(+) GACCCG/TGCACC 1 -- ds50010--------
rs738931091,2
C,F--50432776(+) CCCGGC/TACCTC 1 -- ds50012Minor allele frequency- T:0.13WA 120
rs1825041201,2
C--50432884(+) CTCCAA/CGACAC 1 -- ds50010--------
rs96171411,2
C,H--50432939(+) CCCAAG/ACTCCA 1 -- ds50014Minor allele frequency- A:0.00NS EA 420
rs603325991,2
C,F--50433020(+) AGTCTA/GTGGGA 1 -- ut312Minor allele frequency- G:0.27NA EA 240
rs1866394181,2
--50433135(+) GGGGTA/GCGACC 1 -- ut310--------

HapMap Linkage Disequilibrium report for IL17REL (50432942 - 50451088 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for IL17REL (see all 15):    About this table    
Variant IDTypeSubtypePubMed ID
esv2673064CNV Deletion23128226
esv2724729CNV Deletion23290073
esv2607894CNV Insertion19546169
dgv5050n71CNV Loss21882294
dgv5049n71CNV Loss21882294
nsv915495CNV Loss21882294
dgv5053n71CNV Loss21882294
nsv915519CNV Loss21882294
nsv915520CNV Loss21882294
dgv5046n71CNV Loss21882294

Human Gene Mutation Database (HGMD): IL17REL
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing IL17REL
DNA2.0 Custom Variant and Variant Library Synthesis for IL17REL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 613414    OMIM disorders: --


Find genes that share disorders with IL17REL           About GenesLikeMe

Genetic Association Database (GAD): IL17REL
Human Genome Epidemiology (HuGE) Navigator: IL17REL (1 document)

Export disorders for IL17REL gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IL17REL gene integrated from 10 sources:
(articles sorted by number of sources associating them with IL17REL)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (Nat. Genet. 2011)
  2. Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). (PubMed id 20228798)1, 4 Franke A....Schreiber S. (Nat. Genet. 2010)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I.... Wright H. (Nature 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 400935 HGNC: 33808 AceView: FLJ41993 Ensembl:ENSG00000188263 euGenes: HUgn400935
ECgene: IL17REL H-InvDB: IL17REL

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IL17REL Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IL17REL gene:
Search GeneIP for patents involving IL17REL

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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