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Aliases for IL17REL Gene

Aliases for IL17REL Gene

  • Interleukin 17 Receptor E Like 2 3 5
  • IL-17 Receptor E-Like 3 4
  • IL-17RE-Like 3 4
  • Putative Interleukin-17 Receptor E-Like 3

External Ids for IL17REL Gene

Previous GeneCards Identifiers for IL17REL Gene

  • GC22M048775
  • GC22M050432
  • GC22M033332

Summaries for IL17REL Gene

GeneCards Summary for IL17REL Gene

IL17REL (Interleukin 17 Receptor E Like) is a Protein Coding gene. An important paralog of this gene is IL17RE.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17REL Gene

Genomics for IL17REL Gene

Regulatory Elements for IL17REL Gene

Enhancers for IL17REL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G050009 1.7 FANTOM5 Ensembl ENCODE dbSUPER 7.7 -0.4 -367 8.7 HDGF PKNOX1 FEZF1 GLIS2 ZNF207 JUNB REST NBN PRDM4 CTCF PIM3 MLC1 ENSG00000273253 IL17REL CHKB TUBGCP6 HDAC10 TTLL8
GH22G050467 1.7 FANTOM5 ENCODE dbSUPER 1.3 -458.6 -458631 7.9 HDGF ARID4B SIN3A GLI4 ZNF48 YY1 GLIS2 ZNF143 KLF7 ZNF263 TUBGCP6 CPT1B DENND6B MIOX RPL23AP82 PLXNB2 RABL2B CHKB HDAC10 SBF1
GH22G050007 1 ENCODE dbSUPER 0.7 +4.8 4835 0.9 KLF1 AGO1 BCL11B ZIC2 ZFHX2 GLIS2 POLR2A ZSCAN5C PATZ1 SCRT2 PIM3 IL17REL MIR6821
GH22G050005 1.2 ENCODE dbSUPER 0.4 +6.4 6411 1.9 ELF3 PKNOX1 FOXA2 AGO1 FEZF1 ZNF121 GLIS2 ZNF366 ZSCAN5C SCRT2 PIM3 IL17REL MIR6821
GH22G050029 1.2 Ensembl ENCODE 0.4 -17.7 -17691 2.3 HDGF ARID4B ZNF2 ZNF48 GLIS2 ZNF143 KLF7 SP3 JUNB REST IL17REL TTLL8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL17REL on UCSC Golden Path with GeneCards custom track

Genomic Location for IL17REL Gene

Chromosome:
22
Start:
49,994,513 bp from pter
End:
50,013,198 bp from pter
Size:
18,686 bases
Orientation:
Minus strand

Genomic View for IL17REL Gene

Genes around IL17REL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17REL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17REL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17REL Gene

Proteins for IL17REL Gene

  • Protein details for IL17REL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVW7-I17EL_HUMAN
    Recommended name:
    Putative interleukin-17 receptor E-like
    Protein Accession:
    Q6ZVW7
    Secondary Accessions:
    • A6NCN4
    • A6PVC1

    Protein attributes for IL17REL Gene

    Size:
    336 amino acids
    Molecular mass:
    37514 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IL17REL Gene

Post-translational modifications for IL17REL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL17REL Gene

No data available for DME Specific Peptides for IL17REL Gene

Domains & Families for IL17REL Gene

Protein Domains for IL17REL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL17REL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IL17REL: view

No data available for Gene Families and UniProtKB/Swiss-Prot for IL17REL Gene

Function for IL17REL Gene

Gene Ontology (GO) - Molecular Function for IL17REL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030368 interleukin-17 receptor activity IBA --
genes like me logo Genes that share ontologies with IL17REL: view

Phenotypes for IL17REL Gene

genes like me logo Genes that share phenotypes with IL17REL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL17REL Gene

Localization for IL17REL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL17REL gene
Compartment Confidence
plasma membrane 3
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for IL17REL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with IL17REL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IL17REL Gene

Pathways & Interactions for IL17REL Gene

SuperPathways for IL17REL Gene

No Data Available

Interacting Proteins for IL17REL Gene

Gene Ontology (GO) - Biological Process for IL17REL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019221 cytokine-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with IL17REL: view

No data available for Pathways by source and SIGNOR curated interactions for IL17REL Gene

Drugs & Compounds for IL17REL Gene

No Compound Related Data Available

Transcripts for IL17REL Gene

mRNA/cDNA for IL17REL Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL17REL Gene

Interleukin 17 receptor E-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL17REL Gene

No ASD Table

Relevant External Links for IL17REL Gene

GeneLoc Exon Structure for
IL17REL
ECgene alternative splicing isoforms for
IL17REL

Expression for IL17REL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL17REL Gene

mRNA differential expression in normal tissues according to GTEx for IL17REL Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x10.1), Stomach (x8.0), and Brain - Cortex (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of IL17REL Gene:

IL17REL

SOURCE GeneReport for Unigene cluster for IL17REL Gene:

Hs.526712

Evidence on tissue expression from TISSUES for IL17REL Gene

  • Spleen(4)
genes like me logo Genes that share expression patterns with IL17REL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL17REL Gene

Orthologs for IL17REL Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17REL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL17REL 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL17REL 34 35
  • 79.24 (n)
cow
(Bos Taurus)
Mammalia IL17REL 34 35
  • 77.46 (n)
oppossum
(Monodelphis domestica)
Mammalia IL17REL 35
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL17REL 35
  • 37 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL17REL 34 35
  • 52.71 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia il17rel 34
  • 50.24 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100331195 34
  • 45.96 (n)
il17rel 35
  • 26 (a)
OneToOne
Species where no ortholog for IL17REL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL17REL Gene

ENSEMBL:
Gene Tree for IL17REL (if available)
TreeFam:
Gene Tree for IL17REL (if available)

Paralogs for IL17REL Gene

Paralogs for IL17REL Gene

genes like me logo Genes that share paralogs with IL17REL: view

Variants for IL17REL Gene

Sequence variations from dbSNP and Humsavar for IL17REL Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000190794 -- 49,996,255(+) TCTGT(A/G)GCTGT nc-transcript-variant, utr-variant-3-prime
rs1000240144 -- 50,006,668(+) GCAGA(C/T)TGGGG intron-variant
rs1000283504 -- 50,001,329(+) CTGCA(A/G)TCTTT intron-variant
rs1000432436 -- 50,004,183(+) AAGCG(A/G)TTCTT intron-variant
rs1000961008 -- 50,008,919(+) CACCC(A/G)CTACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL17REL Gene

Variant ID Type Subtype PubMed ID
esv2607894 CNV insertion 19546169
esv2673064 CNV deletion 23128226
esv2724729 CNV deletion 23290073
esv3648077 CNV loss 21293372
esv3648078 CNV loss 21293372
nsv1078803 CNV insertion 25765185
nsv829329 CNV gain 20364138
nsv955197 CNV deletion 24416366

Variation tolerance for IL17REL Gene

Residual Variation Intolerance Score: 84.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.23; 62.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL17REL Gene

Human Gene Mutation Database (HGMD)
IL17REL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL17REL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17REL Gene

Disorders for IL17REL Gene

Relevant External Links for IL17REL

Genetic Association Database (GAD)
IL17REL
Human Genome Epidemiology (HuGE) Navigator
IL17REL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL17REL

No disorders were found for IL17REL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IL17REL Gene

Publications for IL17REL Gene

  1. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson C.A. … Rioux J.D. (Nat. Genet. 2011) 3 46 64
  2. Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). (PMID: 20228798) Franke A. … Schreiber S. (Nat. Genet. 2010) 3 46 64
  3. Whole-exome Sequence Analysis Implicates Rare Il17REL Variants in Familial and Sporadic Inflammatory Bowel Disease. (PMID: 26480299) Sasaki M.M. … Onel K. (Inflamm. Bowel Dis. 2016) 3 64
  4. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for IL17REL Gene

Sources for IL17REL Gene

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