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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL17REL Gene

protein-coding   GIFtS: 37
GCID: GC22M050432

Interleukin 17 Receptor E-Like

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 17 Receptor E-Like1 2
IL-17RE-like2 3
IL-17 Receptor E-Like2 3
Putative Interleukin-17 Receptor E-Like2

External Ids:    HGNC: 338081   Entrez Gene: 4009352   Ensembl: ENSG000001882637   OMIM: 6134145   UniProtKB: Q6ZVW73   

Export aliases for IL17REL gene to outside databases

Previous GC identifers: GC22M048775 GC22M033332


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IL17REL Gene: 
IL17REL (interleukin 17 receptor E-like) is a protein-coding gene. Diseases associated with IL17REL include ulcerative colitis. An important paralog of this gene is IL17RE.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011526.7  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL17REL gene promoter:
         RP58   GCNF   Lmo2   AREB6   PPAR-alpha   PPAR-gamma1   GCNF-1   PPAR-gamma2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL17REL promoter sequence
   Search SABiosciences Chromatin IP Primers for IL17REL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL17REL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.33

IL17REL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL17REL gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M050432:  view genomic region     (about GC identifiers)

Start:
50,432,942 bp from pter      End:
50,451,088 bp from pter
Size:
18,147 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: I17EL_HUMAN, Q6ZVW7 (See protein sequence)
Recommended Name: Putative interleukin-17 receptor E-like  
Size: 336 amino acids; 37514 Da
Secondary accessions: A6NCN4 A6PVC1

Explore the universe of human proteins at neXtProt for IL17REL: NX_Q6ZVW7

Explore proteomics data for IL17REL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZVW7

  • IL17REL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL17REL Protein Expression
    REFSEQ proteins: NP_001001694.2  
    ENSEMBL proteins: 
     ENSP00000374633   ENSP00000342520  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6ZVW7


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IL17REL

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL17REL (I17EL)

    Search CenterWatch for drugs/clinical trials and news about IL17REL / I17EL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for IL17REL gene: 
    NM_001001694.2  

    Unigene Cluster for IL17REL:

    Interleukin 17 receptor E-like
    Hs.526712  [show with all ESTs]
    Unigene Representative Sequence: AK123987
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389983(uc003bje.1) ENST00000341280
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL17REL

    Additional mRNA sequence: AK123987.1 

    1 DOTS entry:

    DT.101966178 

    2 AceView cDNA sequences:

    AK123987 NM_001001694 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL17REL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IL17REL Expression
    About this image


    See IL17REL Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.526712
        SABiosciences Custom PCR Arrays for IL17REL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17REL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL17REL gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia IL17REL1 interleukin 17 receptor E-like 79.75(n)
    72.48(a)
      607159  XM_843760.3  XP_848853.2 
    chicken
    (Gallus gallus)
    Aves IL17REL1 interleukin 17 receptor E-like 52.67(n)
    48.12(a)
      769256  XM_001232492.2  XP_001232493.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003311951 putative interleukin-17 receptor E-like 46.41(n)
    39.71(a)
      100331195  XM_002666890.1  XP_002666936.1 


    ENSEMBL Gene Tree for IL17REL (if available)
    TreeFam Gene Tree for IL17REL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL17REL gene
    IL17RE2  

    IL17REL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/492 SNPs in IL17REL are shown (see all 492)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1903184191,2
    --50432534(+) CCTGGG/TCGAGT 1 -- ds50010--------
    rs1378411,2
    C,F,A,H--50432604(+) GCCCCC/ACACTG 1 -- ds50019Minor allele frequency- A:0.20EA NS NA WA 540
    rs588019581,2
    C--50432744(+) GTGACACTGAC  
      CTTA
    /-
    GCTGA
    1 -- ds50012Minor allele frequency- -:0.00NA CSA 4
    rs1378421,2
    C--50432745(+) GTGACA/GCTGAC 1 -- ds50010--------
    rs1415706601,2
    C--50432774(+) GACCCG/TGCACC 1 -- ds50010--------
    rs738931091,2
    C,F--50432776(+) CCCGGC/TACCTC 1 -- ds50012Minor allele frequency- T:0.13WA 120
    rs1825041201,2
    C--50432884(+) CTCCAA/CGACAC 1 -- ds50010--------
    rs96171411,2
    C,H--50432939(+) CCCAAG/ACTCCA 1 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs603325991,2
    C,F--50433020(+) AGTCTA/GTGGGA 1 -- ut312Minor allele frequency- G:0.27NA EA 240
    rs1866394181,2
    --50433135(+) GGGGTA/GCGACC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for IL17REL (50432942 - 50451088 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for IL17REL (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2673064CNV Deletion23128226
    esv2724729CNV Deletion23290073
    esv2607894CNV Insertion19546169
    dgv5050n71CNV Loss21882294
    dgv5049n71CNV Loss21882294
    nsv915495CNV Loss21882294
    dgv5053n71CNV Loss21882294
    nsv915519CNV Loss21882294
    nsv915520CNV Loss21882294
    dgv5046n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): IL17REL
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IL17REL
    DNA2.0 Custom Variant and Variant Library Synthesis for IL17REL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613414    OMIM disorders: --

    2 diseases for IL17REL:    About MalaCards
    ulcerative colitis    


    IL17REL for disorders           About GeneDecksing

    Genetic Association Database (GAD): IL17REL
    Human Genome Epidemiology (HuGE) Navigator: IL17REL (1 document)

    Export disorders for IL17REL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL17REL gene integrated from 9 sources:
    (articles sorted by number of sources associating them with IL17REL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Meta-analysis identifies 29 additional ulcerative col itis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (2011)
    2. Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). (PubMed id 20228798)1, 4 Franke A....Vatn M.H. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    4. The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 400935 HGNC: 33808 AceView: FLJ41993 Ensembl:ENSG00000188263 euGenes: HUgn400935
    ECgene: IL17REL H-InvDB: IL17REL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL17REL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL17REL gene:
    Search GeneIP for patents involving IL17REL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17REL
     SwitchGear 3'UTR luciferase reporter plasmids for IL17REL
     SwitchGear Promoter luciferase reporter plasmids for IL17REL
     Search ThermoFisher Antibodies for IL17REL
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IL17REL
     inGenious Targeting Laboratory - Custom generated mouse model solutions for IL17REL
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL17REL
    Customized:
     lentivirus for stable overexpression of IL17REL
     lentivirus expression plasmids for stable overexpression of IL17REL
     adenovirus for overexpression of IL17REL
     Search LSBio for Antibodies for IL17REL
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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