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Aliases for IL17REL Gene

Aliases for IL17REL Gene

  • Interleukin 17 Receptor E-Like 2 3 5
  • IL-17 Receptor E-Like 3 4
  • IL-17RE-Like 3 4

External Ids for IL17REL Gene

Previous GeneCards Identifiers for IL17REL Gene

  • GC22M048775
  • GC22M050432
  • GC22M033332

Summaries for IL17REL Gene

GeneCards Summary for IL17REL Gene

IL17REL (Interleukin 17 Receptor E-Like) is a Protein Coding gene. An important paralog of this gene is IL17RE.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17REL Gene

Genomics for IL17REL Gene

Regulatory Elements for IL17REL Gene

Enhancers for IL17REL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL17REL on UCSC Golden Path with GeneCards custom track

Genomic Location for IL17REL Gene

49,994,513 bp from pter
50,013,198 bp from pter
18,686 bases
Minus strand

Genomic View for IL17REL Gene

Genes around IL17REL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17REL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17REL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17REL Gene

Proteins for IL17REL Gene

  • Protein details for IL17REL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative interleukin-17 receptor E-like
    Protein Accession:
    Secondary Accessions:
    • A6NCN4
    • A6PVC1

    Protein attributes for IL17REL Gene

    336 amino acids
    Molecular mass:
    37514 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IL17REL Gene

Proteomics data for IL17REL Gene at MOPED

Post-translational modifications for IL17REL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL17REL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL17REL Gene

Domains & Families for IL17REL Gene

Protein Domains for IL17REL Gene


Suggested Antigen Peptide Sequences for IL17REL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IL17REL: view

No data available for Gene Families and UniProtKB/Swiss-Prot for IL17REL Gene

Function for IL17REL Gene

Phenotypes for IL17REL Gene

GenomeRNAi human phenotypes for IL17REL:
genes like me logo Genes that share phenotypes with IL17REL: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL17REL Gene

Localization for IL17REL Gene

Subcellular locations from

Jensen Localization Image for IL17REL Gene COMPARTMENTS Subcellular localization image for IL17REL gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IL17REL Gene

Pathways & Interactions for IL17REL Gene

SuperPathways for IL17REL Gene

No Data Available

Interacting Proteins for IL17REL Gene

Gene Ontology (GO) - Biological Process for IL17REL Gene


No data available for Pathways by source and SIGNOR curated interactions for IL17REL Gene

Drugs & Compounds for IL17REL Gene

No Compound Related Data Available

Transcripts for IL17REL Gene

mRNA/cDNA for IL17REL Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL17REL Gene

Interleukin 17 receptor E-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL17REL Gene

No ASD Table

Relevant External Links for IL17REL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL17REL Gene

mRNA expression in normal human tissues for IL17REL Gene

mRNA differential expression in normal tissues according to GTEx for IL17REL Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x10.1), Stomach (x8.0), and Brain - Cortex (x5.2).

SOURCE GeneReport for Unigene cluster for IL17REL Gene Hs.526712

genes like me logo Genes that share expression patterns with IL17REL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IL17REL Gene

Orthologs for IL17REL Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17REL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IL17REL 35
  • 77.46 (n)
  • 69.52 (a)
IL17REL 36
  • 69 (a)
(Canis familiaris)
Mammalia IL17REL 35
  • 79.24 (n)
  • 71.17 (a)
IL17REL 36
  • 65 (a)
(Monodelphis domestica)
Mammalia IL17REL 36
  • 41 (a)
(Ornithorhynchus anatinus)
Mammalia IL17REL 36
  • 37 (a)
(Pan troglodytes)
Mammalia IL17REL 36
  • 97 (a)
(Gallus gallus)
Aves IL17REL 35
  • 52.71 (n)
  • 48.44 (a)
IL17REL 36
  • 38 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia il17rel 35
  • 50.24 (n)
  • 41.37 (a)
(Danio rerio)
Actinopterygii LOC100331195 35
  • 45.96 (n)
  • 39.65 (a)
il17rel 36
  • 26 (a)
Species with no ortholog for IL17REL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL17REL Gene

Gene Tree for IL17REL (if available)
Gene Tree for IL17REL (if available)

Paralogs for IL17REL Gene

Paralogs for IL17REL Gene

genes like me logo Genes that share paralogs with IL17REL: view

Variants for IL17REL Gene

Sequence variations from dbSNP and Humsavar for IL17REL Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs5771069 - 49,997,051(+) GCAAA(A/G)GCAGG reference, missense
rs9617090 - 50,000,765(+) CCCCC(C/G/T)CTGCT reference, missense
rs7290572 -- 49,999,547(+) GGCGG(G/T)GGTGG intron-variant
rs137841 -- 49,994,175(+) GCCCC(A/C)CACTG downstream-variant-500B
rs137842 -- 49,994,316(+) GTGAC(A/G)CTGAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for IL17REL Gene

Variant ID Type Subtype PubMed ID
dgv5046n71 CNV Loss 21882294
nsv915495 CNV Loss 21882294
dgv5049n71 CNV Loss 21882294
dgv5050n71 CNV Loss 21882294
nsv915508 CNV Loss 21882294
nsv915512 CNV Gain 21882294
dgv5051n71 CNV Loss 21882294
nsv829329 CNV Gain 20364138
dgv5052n71 CNV Loss 21882294
dgv5053n71 CNV Loss 21882294
nsv915519 CNV Loss 21882294
nsv915520 CNV Loss 21882294
esv2724729 CNV Deletion 23290073
esv2673064 CNV Deletion 23128226
esv2607894 CNV Insertion 19546169

Variation tolerance for IL17REL Gene

Residual Variation Intolerance Score: 84.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.23; 62.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL17REL Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17REL Gene

Disorders for IL17REL Gene

Relevant External Links for IL17REL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IL17REL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IL17REL Gene

Publications for IL17REL Gene

  1. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson C.A. … Rioux J.D. (Nat. Genet. 2011) 3 48 67
  2. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3
  3. Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). (PMID: 20228798) Franke A. … Schreiber S. (Nat. Genet. 2010) 3

Products for IL17REL Gene

Sources for IL17REL Gene