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Aliases for IL17RE Gene

Aliases for IL17RE Gene

  • Interleukin 17 Receptor E 2 3
  • IL-17 Receptor E 4
  • IL-17RE 4

External Ids for IL17RE Gene

Previous GeneCards Identifiers for IL17RE Gene

  • GC03P009936
  • GC03P009919
  • GC03P009903
  • GC03P009944
  • GC03P009880

Summaries for IL17RE Gene

Entrez Gene Summary for IL17RE Gene

  • This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for IL17RE Gene

IL17RE (Interleukin 17 Receptor E) is a Protein Coding gene. Among its related pathways are IL-17 Family Signaling Pathways and IL-17 Family Signaling Pathways. An important paralog of this gene is IL17REL.

UniProtKB/Swiss-Prot for IL17RE Gene

  • Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17RE Gene

Genomics for IL17RE Gene

Regulatory Elements for IL17RE Gene

Transcription factor binding sites by QIAGEN in the IL17RE gene promoter:

Genomic Location for IL17RE Gene

Start:
9,902,612 bp from pter
End:
9,916,402 bp from pter
Size:
13,791 bases
Orientation:
Plus strand

Genomic View for IL17RE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL17RE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17RE Gene

Proteins for IL17RE Gene

  • Protein details for IL17RE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFR9-I17RE_HUMAN
    Recommended name:
    Interleukin-17 receptor E
    Protein Accession:
    Q8NFR9
    Secondary Accessions:
    • B2RB34
    • B2RNR1
    • B9EH65
    • Q6P532
    • Q8N8H7
    • Q8N8H8
    • Q8TEC2

    Protein attributes for IL17RE Gene

    Size:
    667 amino acids
    Molecular mass:
    74810 Da
    Quaternary structure:
    • Forms heterodimers with IL17RA; the heterodimer binds IL17C

    Alternative splice isoforms for IL17RE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL17RE Gene

Proteomics data for IL17RE Gene at MOPED

Post-translational modifications for IL17RE Gene

  • Glycosylation at Asn318, Asn347, and Asn364
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for IL17RE Gene

Domains for IL17RE Gene

Gene Families for IL17RE Gene

HGNC:
  • IL :Interleukins and interleukin receptors
IUPHAR :

Protein Domains for IL17RE Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8NFR9

UniProtKB/Swiss-Prot:

I17RE_HUMAN :
  • Q8NFR9
Domain:
  • Contains 1 SEFIR domain.
genes like me logo Genes that share domains with IL17RE: view

Function for IL17RE Gene

Molecular function for IL17RE Gene

UniProtKB/Swiss-Prot Function:
Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.

Gene Ontology (GO) - Molecular Function for IL17RE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21993848
GO:0030368 interleukin-17 receptor activity IBA --
genes like me logo Genes that share ontologies with IL17RE: view
genes like me logo Genes that share phenotypes with IL17RE: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL17RE

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IL17RE Gene

Localization for IL17RE Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17RE Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cytoplasm.
Isoform 3: Secreted.
Isoform 4: Cytoplasm.
Isoform 5: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL17RE Gene COMPARTMENTS Subcellular localization image for IL17RE gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IL17RE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with IL17RE: view

Pathways for IL17RE Gene

genes like me logo Genes that share pathways with IL17RE: view

Pathways by source for IL17RE Gene

1 BioSystems pathway for IL17RE Gene
1 R&D Systems pathway for IL17RE Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for IL17RE Gene

Selected Interacting proteins: Q8NFR9-I17RE_HUMAN for IL17RE Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for IL17RE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0019221 cytokine-mediated signaling pathway IBA --
genes like me logo Genes that share ontologies with IL17RE: view

Transcripts for IL17RE Gene

Unigene Clusters for IL17RE Gene

Interleukin 17 receptor E:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL17RE

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL17RE Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16
SP1: - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8: -

Relevant External Links for IL17RE Gene

GeneLoc Exon Structure for
IL17RE
ECgene alternative splicing isoforms for
IL17RE

Expression for IL17RE Gene

mRNA expression in normal human tissues for IL17RE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL17RE Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (6.6), Skin - Not Sun Exposed (Suprapubic) (5.6), and Colon - Transverse (4.3).

Protein differential expression in normal tissues for IL17RE Gene

This gene is overexpressed in Esophagus (35.2) and Stomach (33.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IL17RE Gene

SOURCE GeneReport for Unigene cluster for IL17RE Gene Hs.390823

mRNA Expression by UniProt/SwissProt for IL17RE Gene

Q8NFR9-I17RE_HUMAN
Tissue specificity: Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines.
genes like me logo Genes that share expressions with IL17RE: view

Expression partners for IL17RE Gene

In Situ Assay Products

Orthologs for IL17RE Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17RE Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL17RE 35
  • 83.57 (n)
  • 77.21 (a)
IL17RE 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL17RE 35
  • 84.46 (n)
  • 77.53 (a)
IL17RE 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il17re 35
  • 78.38 (n)
  • 73.65 (a)
Il17re 16
Il17re 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL17RE 35
  • 99.2 (n)
  • 98.73 (a)
IL17RE 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il17re 35
  • 78.26 (n)
  • 73.91 (a)
oppossum
(Monodelphis domestica)
Mammalia IL17RE 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL17RE 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL17RE 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL17RE 36
  • 45 (a)
OneToOne
Species with no ortholog for IL17RE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL17RE Gene

ENSEMBL:
Gene Tree for IL17RE (if available)
TreeFam:
Gene Tree for IL17RE (if available)

Paralogs for IL17RE Gene

Paralogs for IL17RE Gene

genes like me logo Genes that share paralogs with IL17RE: view

Variants for IL17RE Gene

Sequence variations from dbSNP and Humsavar for IL17RE Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs172154 -- 9,913,559(+) ACCCA(A/G)GTCTC intron-variant
rs172155 -- 9,908,954(+) AATGC(A/G)ACCTC intron-variant
rs188090 -- 9,909,936(+) GGGCA(A/G)GACTT intron-variant
rs279566 -- 9,913,499(+) AACCT(A/G)CCTCC intron-variant
rs279567 -- 9,913,386(+) acgac(A/G)gagca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL17RE Gene

Variant ID Type Subtype PubMed ID
nsv834615 CNV Loss 17160897

Relevant External Links for IL17RE Gene

HapMap Linkage Disequilibrium report
IL17RE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17RE Gene

Disorders for IL17RE Gene

Relevant External Links for IL17RE

Genetic Association Database (GAD)
IL17RE
Human Genome Epidemiology (HuGE) Navigator
IL17RE

No disorders were found for IL17RE Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for IL17RE Gene

Publications for IL17RE Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Identification and functional characterization of a novel interleukin 17 receptor: a possible mitogenic activation through ras/mitogen- activated protein kinase signaling pathway. (PMID: 16310341) Li T.-S. … Liu L. (Cell. Signal. 2006) 3 4
  4. Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring. (PMID: 20459687) Eid N.A. … Ibrahim M.E. (Malar. J. 2010) 3 48
  5. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. (PMID: 21993848) Ramirez-Carrozzi V. … Pappu R. (Nat. Immunol. 2011) 3 4

Products for IL17RE Gene

Sources for IL17RE Gene

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