External Ids for IL17RE Gene
Previous GeneCards Identifiers for IL17RE Gene
This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]
GeneCards Summary for IL17RE Gene
IL17RE (Interleukin 17 Receptor E) is a Protein Coding gene. Diseases associated with IL17RE include malaria. Among its related pathways are IL-17 Family Signaling Pathways and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include interleukin-17 receptor activity. An important paralog of this gene is IL17REL.
UniProtKB/Swiss-Prot for IL17RE Gene
Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.