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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL17RE Gene

protein-coding   GIFtS: 47
GCID: GC03P009944

interleukin 17 receptor E

 Explore 1 disease affiliated with
IL17RE via our new
 Human Malady Compendium 
Biological research products
for IL17RE
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Interleukin 17 Receptor E1 2
IL-17 Receptor E2 3
FLJ236581
Interleukin-17 Receptor E2
IL-17RE3

External Ids:    HGNC: 184391   Entrez Gene: 1320142   Ensembl: ENSG000001637017   OMIM: 6149955   UniProtKB: Q8NFR93   

Export aliases for IL17RE gene to outside databases

Previous GC identifers: GC03P009936 GC03P009919 GC03P009903 GC03P009880


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL17RE:
This gene encodes a protein that shares limited similarity with the interleukin-17 receptor. The function of the
encoded protein has not yet been determined. Alternatively spliced transcript variants have been described. (provided
by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: I17RE_HUMAN, Q8NFR9
Function: Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May
require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2
and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble
decoy receptors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL17RE gene promoter:
         AP-1   ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL17RE promoter sequence
   Search SABiosciences Chromatin IP Primers for IL17RE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL17RE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.3   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25.3

IL17RE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL17RE gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P009944:  view genomic region     (about GC identifiers)

Start:
9,944,296 bp from pter      End:
9,958,086 bp from pter
Size:
13,791 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: I17RE_HUMAN, Q8NFR9 (See protein sequence)
Recommended Name: Interleukin-17 receptor E precursor  
Size: 667 amino acids; 74810 Da
Subunit: Forms heterodimers with IL17RA; the heterodimer binds IL17C
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein (By similarity)
Subcellular location: Isoform 2: Cytoplasm (Probable)
Subcellular location: Isoform 3: Secreted (Probable)
Subcellular location: Isoform 4: Cytoplasm (Probable)
Subcellular location: Isoform 5: Secreted (Probable)
Secondary accessions: B2RB34 B2RNR1 B9EH65 Q6P532 Q8N8H7 Q8N8H8 Q8TEC2
Alternative splicing: 5 isoforms:  Q8NFR9-1   Q8NFR9-2   Q8NFR9-3   Q8NFR9-4   Q8NFR9-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IL17RE: NX_Q8NFR9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NFR9

  • IL17RE Protein expression data from MOPED and PaxDb:    About this image 
    IL17RE Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001180309.1  NP_705613.1  NP_705616.2  

    ENSEMBL proteins: 
     ENSP00000404916   ENSP00000373325   ENSP00000406076   ENSP00000415701   ENSP00000388086  
     ENSP00000373326   ENSP00000400768   ENSP00000295980  

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    Uscn Proteins for IL17RE

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    IL17RE for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    IL17RE for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR013568 SEFIR

    Graphical View of Domain Structure for InterPro Entry Q8NFR9

    ProtoNet protein and cluster: Q8NFR9

    1 Blocks protein family: IPB013568 SEFIR

    UniProtKB/Swiss-Prot: I17RE_HUMAN, Q8NFR9
    Similarity: Contains 1 SEFIR domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I17RE_HUMAN, Q8NFR9
    Function: Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May
    require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2
    and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble
    decoy receptors

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005515protein binding IPI--
         
    IL17RE for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IL17RE:
     Decreased Salmonella enterica  

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il17re):
     digestive/alimentary  endocrine/exocrine gland  growth/size  immune system  integument 

    IL17RE for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for IL17RE 

    miRNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17RE


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IL17RE

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for IL17RE (Q8NFR91, 3 ENSP000002959804) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL17RAQ96F461, ENSP000003209364EBI-5591275,EBI-5591258 STRING: ENSP00000320936
    TRAF6Q9Y4K33I2D: score=1 
    IL17CENSP000002442414STRING: ENSP00000244241
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--

    IL17RE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL17RE
    Search CenterWatch for drugs/clinical trials and news about IL17RE / I17RE 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL17RE gene (6 alternative transcripts): 
    NM_001193380.1  NM_153480.1  NM_153483.2  NM_144640.2  NM_153481.1  NM_153482.1  

    Unigene Cluster for IL17RE:

    Interleukin 17 receptor E
    Hs.390823  [show with all ESTs]
    Unigene Representative Sequence: NM_001193380
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461534 ENST00000421412 ENST00000383814(uc011atn.1 uc003btw.3 uc003btx.3)
    ENST00000489181(uc003btv.3) ENST00000444427 ENST00000434065 ENST00000454190(uc010hcq.3)
    ENST00000383815(uc003bty.3) ENST00000454992 ENST00000483258 ENST00000480244
    ENST00000295980(uc003btu.3)

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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF458069.1 AK074238.1 AK096801.1 AK297697.1 AK298025.1 AK314476.1 AY358451.1 BC035478.1 
    BC063110.1 BC137077.1 BC137078.1 

    10 DOTS entries:

    DT.100023851  DT.99958640  DT.313599  DT.100775699  DT.101971300  DT.75101450  DT.313600  DT.92415417 
    DT.91944238  DT.95365657 

    24/65 AceView cDNA sequences (see all 65):

    NM_153481 NM_153480 CK820986 CK820985 BX281621 AK096793 NM_153483 BF514376 
    BQ082329 BQ082315 AK074238 NM_144640 BQ082324 BX356451 NM_153482 AI376837 
    AI473245 BQ082318 BQ082330 BI793051 BQ082316 AI391722 AI703323 AW341627 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IL17RE (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16
    SP1:                    -                                               -                       -                                             
    SP2:                    -     -                                         -                       -                 -     -                     
    SP3:                                                                    -                       -                 -     -                     
    SP4:                                                                    -                       -                 -                           
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for IL17RE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL17RE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACAAACTAAG
    IL17RE Expression
    About this image
    See IL17RE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL17RE

    SOURCE GeneReport for Unigene cluster: Hs.390823

    UniProtKB/Swiss-Prot: I17RE_HUMAN, Q8NFR9
    Tissue specificity: Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial
    cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL17RE: 
              Th17 Response in human mouse rat
              T Helper Cell Differentiation in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17RE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL17RE gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia IL17RE6
    --
    46(a)
    1 ↔ 1
    2(191391134-191406105)
    zebrafish
    (Danio rerio)
    Actinopterygii CU179703.16
    --
    18(a)
    1 → many
    25(30464134-30489505)


    ENSEMBL Gene Tree for IL17RE (if available)
    TreeFam Gene Tree for IL17RE (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL17RE gene
    IL17REL2  IL17RC2  

    IL17RE for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/309 NCBI SNPs in IL17RE are shown (see all 309    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs731183351,2
    C,F--9942299(+) ATAGAG/TAATTG 1 -- us2k13Minor allele frequency- T:0.06WA CSA 122
    rs1134195831,2
    C,F--9942310(+) GTACCG/AGGCAC 1 -- us2k13Minor allele frequency- A:0.05WA CSA 122
    rs1435616061,2
    --9942402(+) GGCCAA/GTGTGG 1 -- us2k10--------
    rs1380789611,2
    --9942697(+) GACCAC/GCCTGG 3 -- us2k10--------
    rs1416799771,2
    --9942784(+) TACTCC/GGGAGG 3 -- us2k10--------
    rs1847888041,2
    --9942796(+) TGAGGC/TGGGAG 3 -- us2k10--------
    rs1879735241,2
    --9942824(+) AGGTGA/GAGATT 3 -- us2k10--------
    rs593383021,2
    C--9942892(+) AAAAAAA/-GAGAG 3 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1470561181,2
    --9942963(+) ATAGAC/TTTTGA 3 -- us2k10--------
    rs1146889271,2
    --9942978(+) GTCCAA/CATCAT 3 -- us2k11Minor allele frequency- C:0.01NA 120

    HapMap Linkage Disequilibrium report for IL17RE (9944296 - 9958086 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IL17RE: --

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for IL17RE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IL17RE for disorders           About GeneDecksing

    OMIM gene information: 614995    OMIM disorders: --

    1 disease for IL17RE:    About MalaCards
    malaria

    Human Genome Epidemiology (HuGE) Navigator: IL17RE (1 document)

    Export disorders for IL17RE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL17RE gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with IL17RE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IL-17RE is the functional receptor for IL-17C and medi ates mucosal immunity to infection with intestinal pathogens. (PubMed id 21993849)1, 2 Song X....Qian Y. (2011)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. IL-17C regulates the innate immune function of epithel ial cells in an autocrine manner. (PubMed id 21993848)2 Ramirez-Carrozzi V....Pappu R. (2011)
    5. Candidate malaria susceptibility/protective SNPs in h ospital and population-based studies: the effect of sub-structuring. (PubMed id 20459687)1 Eid N.A....Ibrahim M.E. (2010)
    6. Identification and functional characterization of a novel interleukin 17 receptor: a possible mitogenic activation through ras/mitogen- activated protein kinase signaling pathway. (PubMed id 16310341)2 Li T.-S.... Liu L. (2006)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 132014 HGNC: 18439 AceView: IL17RE Ensembl:ENSG00000163701 euGenes: HUgn132014
    ECgene: IL17RE H-InvDB: IL17RE

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    PharmGKB entry for IL17RE Pharmacogenomics, SNPs, Pathways

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    Patent Information for IL17RE gene:
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