Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IL17RE Gene

Aliases for IL17RE Gene

  • Interleukin 17 Receptor E 2 3 5
  • IL-17 Receptor E 4
  • IL-17RE 4

External Ids for IL17RE Gene

Previous GeneCards Identifiers for IL17RE Gene

  • GC03P009936
  • GC03P009919
  • GC03P009903
  • GC03P009944
  • GC03P009880
  • GC03P009904
  • GC03P009905
  • GC03P009906
  • GC03P009914
  • GC03P009916

Summaries for IL17RE Gene

Entrez Gene Summary for IL17RE Gene

  • This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for IL17RE Gene

IL17RE (Interleukin 17 Receptor E) is a Protein Coding gene. Diseases associated with IL17RE include Malaria. Among its related pathways are IL-17 Family Signaling Pathways and Innate Immune System. GO annotations related to this gene include interleukin-17 receptor activity. An important paralog of this gene is IL17REL.

UniProtKB/Swiss-Prot for IL17RE Gene

  • Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17RE Gene

Genomics for IL17RE Gene

Regulatory Elements for IL17RE Gene

Enhancers for IL17RE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G009861 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.7 -38.4 -38436 4.9 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF766 ZNF143 IL17RC JAGN1 CIDEC TADA3 IL17RE ARPC4 RNU6-882P TTLL3 RAD18 ARPC4-TTLL3
GH03G009975 1.6 Ensembl ENCODE dbSUPER 11.1 +76.2 76152 4.8 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 FANCD2 BRK1 PRRT3 CIDECP IL17RE RPUSD3 VHL JAGN1 LINC00852 ARPC4
GH03G009870 1.2 ENCODE dbSUPER 12.8 -30.9 -30897 1.1 ATF1 PKNOX1 ARNT FEZF1 YY1 ZNF121 GATA2 FOS MAFF SMARCA4 JAGN1 IL17RE RPUSD3 RNU6-882P IL17RC TTLL3 FANCD2 ARPC4 ARPC4-TTLL3 TADA3
GH03G010247 1.4 ENCODE dbSUPER 10.2 +347.2 347165 3.0 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 GHRLOS GHRL IRAK2 FANCD2OS VHL SEC13 IL17RE JAGN1 ARPC4 TADA3
GH03G010263 1.3 Ensembl ENCODE dbSUPER 10.6 +362.1 362075 1.0 CTCF LEF1 PKNOX1 TBL1XR1 RAD21 IRF9 ZFHX2 EGR1 POLR2A NFE2 GHRLOS LINC00852 GHRL IRAK2 IL17RC RNU6-882P IL17RE PRRT3 PIR57384 PIR32054
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL17RE on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the IL17RE gene promoter:

Genomic Location for IL17RE Gene

Chromosome:
3
Start:
9,902,062 bp from pter
End:
9,916,402 bp from pter
Size:
14,341 bases
Orientation:
Plus strand

Genomic View for IL17RE Gene

Genes around IL17RE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17RE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17RE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17RE Gene

Proteins for IL17RE Gene

  • Protein details for IL17RE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFR9-I17RE_HUMAN
    Recommended name:
    Interleukin-17 receptor E
    Protein Accession:
    Q8NFR9
    Secondary Accessions:
    • B2RB34
    • B2RNR1
    • B9EH65
    • Q6P532
    • Q8N8H7
    • Q8N8H8
    • Q8TEC2

    Protein attributes for IL17RE Gene

    Size:
    667 amino acids
    Molecular mass:
    74810 Da
    Quaternary structure:
    • Forms heterodimers with IL17RA; the heterodimer binds IL17C.

    Alternative splice isoforms for IL17RE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL17RE Gene

Post-translational modifications for IL17RE Gene

  • Glycosylation at posLast=318318, isoforms=2, 3, 4347, and posLast=364364
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IL17RE Gene

Domains & Families for IL17RE Gene

Gene Families for IL17RE Gene

Protein Domains for IL17RE Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IL17RE: view

No data available for UniProtKB/Swiss-Prot for IL17RE Gene

Function for IL17RE Gene

Molecular function for IL17RE Gene

UniProtKB/Swiss-Prot Function:
Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors.

Gene Ontology (GO) - Molecular Function for IL17RE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21993848
GO:0030368 interleukin-17 receptor activity IBA --
genes like me logo Genes that share ontologies with IL17RE: view
genes like me logo Genes that share phenotypes with IL17RE: view

Animal Models for IL17RE Gene

MGI Knock Outs for IL17RE:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL17RE

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL17RE Gene

Localization for IL17RE Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17RE Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cytoplasm.
Isoform 3: Secreted.
Isoform 4: Cytoplasm.
Isoform 5: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL17RE gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IL17RE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IL17RE: view

Pathways & Interactions for IL17RE Gene

genes like me logo Genes that share pathways with IL17RE: view

Pathways by source for IL17RE Gene

1 R&D Systems pathway for IL17RE Gene

Interacting Proteins for IL17RE Gene

Gene Ontology (GO) - Biological Process for IL17RE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0019221 cytokine-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with IL17RE: view

No data available for SIGNOR curated interactions for IL17RE Gene

Drugs & Compounds for IL17RE Gene

No Compound Related Data Available

Transcripts for IL17RE Gene

Unigene Clusters for IL17RE Gene

Interleukin 17 receptor E:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL17RE Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16
SP1: - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8: -

Relevant External Links for IL17RE Gene

GeneLoc Exon Structure for
IL17RE
ECgene alternative splicing isoforms for
IL17RE

Expression for IL17RE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL17RE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL17RE Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.6), Skin - Not Sun Exposed (Suprapubic) (x5.6), and Colon - Transverse (x4.3).

Protein differential expression in normal tissues from HIPED for IL17RE Gene

This gene is overexpressed in Esophagus (35.2) and Stomach (33.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL17RE Gene



Protein tissue co-expression partners for IL17RE Gene

NURSA nuclear receptor signaling pathways regulating expression of IL17RE Gene:

IL17RE

SOURCE GeneReport for Unigene cluster for IL17RE Gene:

Hs.390823

mRNA Expression by UniProt/SwissProt for IL17RE Gene:

Q8NFR9-I17RE_HUMAN
Tissue specificity: Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines.

Evidence on tissue expression from TISSUES for IL17RE Gene

  • Skin(4.4)
  • Lung(4.2)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with IL17RE: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IL17RE Gene

Orthologs for IL17RE Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17RE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL17RE 34 35
  • 99.2 (n)
dog
(Canis familiaris)
Mammalia IL17RE 34 35
  • 84.46 (n)
cow
(Bos Taurus)
Mammalia IL17RE 34 35
  • 83.57 (n)
mouse
(Mus musculus)
Mammalia Il17re 34 16 35
  • 78.38 (n)
rat
(Rattus norvegicus)
Mammalia Il17re 34
  • 78.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IL17RE 35
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL17RE 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL17RE 35
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL17RE 35
  • 45 (a)
OneToOne
Species where no ortholog for IL17RE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL17RE Gene

ENSEMBL:
Gene Tree for IL17RE (if available)
TreeFam:
Gene Tree for IL17RE (if available)

Paralogs for IL17RE Gene

Paralogs for IL17RE Gene

genes like me logo Genes that share paralogs with IL17RE: view

Variants for IL17RE Gene

Sequence variations from dbSNP and Humsavar for IL17RE Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000257917 -- 9,904,506(+) TAGGC(C/G)AGGCG intron-variant
rs1000337096 -- 9,904,865(+) AAGGT(A/G)GGTGG intron-variant
rs1000408075 -- 9,910,656(+) CTCCA(G/T)ACTGG intron-variant
rs1000501438 -- 9,900,836(+) GAGGC(A/G)GAGGT upstream-variant-2KB
rs1000730993 -- 9,902,658(+) TGTTA(C/T)TTCTC intron-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IL17RE Gene

Variant ID Type Subtype PubMed ID
nsv1073203 CNV deletion 25765185
nsv589648 CNV loss 21841781
nsv834615 CNV loss 17160897

Variation tolerance for IL17RE Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL17RE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL17RE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17RE Gene

Disorders for IL17RE Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL17RE Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
malaria
  • malaria, severe
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IL17RE

Genetic Association Database (GAD)
IL17RE
Human Genome Epidemiology (HuGE) Navigator
IL17RE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL17RE
genes like me logo Genes that share disorders with IL17RE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL17RE Gene

Publications for IL17RE Gene

  1. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. (PMID: 21993848) Ramirez-Carrozzi V. … Pappu R. (Nat. Immunol. 2011) 3 4 64
  2. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. (PMID: 21993849) Song X. … Qian Y. (Nat. Immunol. 2011) 3 4 64
  3. Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring. (PMID: 20459687) Eid N.A. … Ibrahim M.E. (Malar. J. 2010) 3 46 64
  4. Identification and functional characterization of a novel interleukin 17 receptor: a possible mitogenic activation through ras/mitogen- activated protein kinase signaling pathway. (PMID: 16310341) Li T.-S. … Liu L. (Cell. Signal. 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for IL17RE Gene

Sources for IL17RE Gene

Content
Loading form....