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Aliases for IL17RD Gene

Aliases for IL17RD Gene

  • Interleukin 17 Receptor D 2 3
  • SEF 3 4 6
  • Interleukin-17 Receptor-Like Protein 3 4
  • IL-17 Receptor D 3 4
  • Sef Homolog 3 4
  • IL17Rhom 3 4
  • IL-17RD 3 4
  • IL17RLM 3 4
  • HH18 3 6
  • HSef 3 4
  • Interleukin-17 Receptor D 3

External Ids for IL17RD Gene

Previous GeneCards Identifiers for IL17RD Gene

  • GC03M056983
  • GC03M057085
  • GC03M057103

Summaries for IL17RD Gene

Entrez Gene Summary for IL17RD Gene

  • This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin (PMID: 19079364). The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling (PMID: 21663947, 18096367). [provided by RefSeq, Nov 2011]

GeneCards Summary for IL17RD Gene

IL17RD (Interleukin 17 Receptor D) is a Protein Coding gene. Diseases associated with IL17RD include hypogonadotropic hypogonadism 18 with or without anosmia and kallmann syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR.

UniProtKB/Swiss-Prot for IL17RD Gene

  • Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17RD Gene

Genomics for IL17RD Gene

Regulatory Elements for IL17RD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IL17RD Gene

Start:
57,089,982 bp from pter
End:
57,170,306 bp from pter
Size:
80,325 bases
Orientation:
Minus strand

Genomic View for IL17RD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL17RD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17RD Gene

Proteins for IL17RD Gene

  • Protein details for IL17RD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFM7-I17RD_HUMAN
    Recommended name:
    Interleukin-17 receptor D
    Protein Accession:
    Q8NFM7
    Secondary Accessions:
    • Q2NKP7
    • Q58EZ7
    • Q6RVF4
    • Q6UWI5
    • Q8N113
    • Q8NFS0
    • Q9UFA0

    Protein attributes for IL17RD Gene

    Size:
    739 amino acids
    Molecular mass:
    82411 Da
    Quaternary structure:
    • Interacts with MAP3K7 (By similarity). Self-associates. Interacts with FGFR1, FGFR2 and phosphorylated MAP2K1 or MAP2K2. Associates with a MAP2K1/2-MAPK1/3 complex.

    Alternative splice isoforms for IL17RD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL17RD Gene

Proteomics data for IL17RD Gene at MOPED

Post-translational modifications for IL17RD Gene

  • Glycosylation at Asn19, Asn55, Asn62, Asn80, Asn137, Asn171, Asn206, and Asn277
  • Modification sites at PhosphoSitePlus

Other Protein References for IL17RD Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IL17RD (IL-17 RD/SEF)

No data available for DME Specific Peptides for IL17RD Gene

Domains for IL17RD Gene

Gene Families for IL17RD Gene

HGNC:
  • IL :Interleukins and interleukin receptors
IUPHAR :

Protein Domains for IL17RD Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for IL17RD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NFM7

UniProtKB/Swiss-Prot:

I17RD_HUMAN :
  • Q8NFM7
Domain:
  • Contains 1 SEFIR domain.
genes like me logo Genes that share domains with IL17RD: view

Function for IL17RD Gene

Molecular function for IL17RD Gene

UniProtKB/Swiss-Prot Function: Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity).

Gene Ontology (GO) - Molecular Function for IL17RD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0030368 interleukin-17 receptor activity IBA --
genes like me logo Genes that share ontologies with IL17RD: view

Phenotypes for IL17RD Gene

genes like me logo Genes that share phenotypes with IL17RD: view

Animal Models for IL17RD Gene

MGI Knock Outs for IL17RD:

Animal Model Products

CRISPR Products

miRNA for IL17RD Gene

miRTarBase miRNAs that target IL17RD

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL17RD

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL17RD Gene

Localization for IL17RD Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17RD Gene

Golgi apparatus membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Predominantly associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation.
Isoform 4: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL17RD Gene COMPARTMENTS Subcellular localization image for IL17RD gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
nucleus 3
extracellular 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL17RD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane --
genes like me logo Genes that share ontologies with IL17RD: view

Pathways for IL17RD Gene

genes like me logo Genes that share pathways with IL17RD: view

Pathways by source for IL17RD Gene

2 BioSystems pathways for IL17RD Gene
1 R&D Systems pathway for IL17RD Gene

Interacting Proteins for IL17RD Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296318%0d%0a9606.ENSP00000393312%0d%0a9606.ENSP00000358335%0d%0a
Selected Interacting proteins: ENSP00000296318 Q8NFM7-I17RD_HUMAN for IL17RD Gene via STRING I2D

Gene Ontology (GO) - Biological Process for IL17RD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0019221 cytokine-mediated signaling pathway IBA --
genes like me logo Genes that share ontologies with IL17RD: view

Compounds for IL17RD Gene

(1) Novoseek inferred chemical compound relationships for IL17RD Gene

Compound -log(P) Hits PubMed IDs
tyrosine 41.1 3
genes like me logo Genes that share compounds with IL17RD: view

Transcripts for IL17RD Gene

Unigene Clusters for IL17RD Gene

Interleukin 17 receptor D:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL17RD

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL17RD Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - -
SP2: -
SP3:

Relevant External Links for IL17RD Gene

GeneLoc Exon Structure for
IL17RD
ECgene alternative splicing isoforms for
IL17RD

Expression for IL17RD Gene

mRNA expression in normal human tissues for IL17RD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL17RD Gene

This gene is overexpressed in Uterus (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL17RD Gene

SOURCE GeneReport for Unigene cluster for IL17RD Gene Hs.150725

mRNA Expression by UniProt/SwissProt for IL17RD Gene

Q8NFM7-I17RD_HUMAN
Tissue specificity: Expressed in umbilical vein endothelial cells and in several highly vascularized tissues such as kidney, colon, skeletal muscle, heart and small intestine. Highly expressed in ductal epithelial cells of salivary glands, seminal vesicles and the collecting tubules of the kidney. Isoform 1 is also highly expressed in both fetal and adult brain, pituitary, tonsils, spleen, adenoids, fetal kidney, liver, testes and ovary. Isoform 1 is also expressed at moderate levels in primary aortic endothelial cells and adrenal medulla, and at low levels in adrenal cortex. Isoform 4 is specifically and highly expressed in pituitary, fetal brain and umbilical vein endothelial cells.
genes like me logo Genes that share expressions with IL17RD: view

In Situ Assay Products

Orthologs for IL17RD Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17RD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL17RD 35
  • 99.27 (n)
  • 99.16 (a)
IL17RD 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL17RD 35
  • 87.44 (n)
  • 89.12 (a)
IL17RD 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL17RD 35
  • 87.83 (n)
  • 90.62 (a)
IL17RD 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il17rd 35
  • 85.12 (n)
  • 87.89 (a)
Il17rd 16
Il17rd 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL17RD 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Il17rd 35
  • 85.66 (n)
  • 87.65 (a)
chicken
(Gallus gallus)
Aves IL17RD 35
  • 72.14 (n)
  • 74.36 (a)
IL17RD 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL17RD 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il17rd 35
  • 68.85 (n)
  • 66.1 (a)
Str.19050 35
zebrafish
(Danio rerio)
Actinopterygii il17rd 35
  • 60.16 (n)
  • 56.13 (a)
il17rd 36
  • 51 (a)
OneToMany
IL17RD (2 of 2) 36
  • 23 (a)
OneToMany
Species with no ortholog for IL17RD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL17RD Gene

ENSEMBL:
Gene Tree for IL17RD (if available)
TreeFam:
Gene Tree for IL17RD (if available)

Paralogs for IL17RD Gene

No data available for Paralogs for IL17RD Gene

Variants for IL17RD Gene

Sequence variations from dbSNP and Humsavar for IL17RD Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs14567 -- 57,090,026(+) TACAA(A/C)AACAT utr-variant-3-prime
rs747088 -- 57,119,654(+) CCCAG(A/T)TTCAC intron-variant
rs747089 -- 57,119,841(+) GCCAC(C/T)ATATT intron-variant
rs768712 -- 57,124,168(+) TTCAG(C/T)TGCTC intron-variant
rs768713 -- 57,124,309(+) tgtga(C/G)tatgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL17RD Gene

Variant ID Type Subtype PubMed ID
nsv876819 CNV Gain 21882294
nsv819583 CNV Gain 19587683
nsv3835 CNV Loss 18451855

Relevant External Links for IL17RD Gene

HapMap Linkage Disequilibrium report
IL17RD
Human Gene Mutation Database (HGMD)
IL17RD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17RD Gene

Disorders for IL17RD Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for IL17RD Gene including...

Search for IL17RD Gene in MalaCards »

(1) OMIM Diseases for IL17RD Gene (606807)

UniProtKB/Swiss-Prot

I17RD_HUMAN
  • Hypogonadotropic hypogonadism 18 with or without anosmia (HH18) [MIM:615267]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269 PubMed:23643382}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in IL17RD also have a heterozygous mutation in another HH-associated gene including FGFR1 and KISS1R (PubMed:23643382). {ECO:0000269 PubMed:23643382}.

Relevant External Links for IL17RD

Genetic Association Database (GAD)
IL17RD
Human Genome Epidemiology (HuGE) Navigator
IL17RD
genes like me logo Genes that share disorders with IL17RD: view

Publications for IL17RD Gene

  1. hSef inhibits PC-12 cell differentiation by interfering with Ras- mitogen-activated protein kinase MAPK signaling. (PMID: 12958313) Xiong S.Q. … Chang Z.J. (J. Biol. Chem. 2003) 3 4 23
  2. Alternative splicing generates an isoform of the human Sef gene with altered subcellular localization and specificity. (PMID: 14742870) Preger E. … Ron D. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23
  3. Loss of Sef (similar expression to FGF) expression is associated with high grade and metastatic prostate cancer. (PMID: 16474841) Darby S. … Gnanapragasam V.J. (Oncogene 2006) 3 23
  4. Downregulation of Sef, an inhibitor of receptor tyrosine kinase signaling, is common to a variety of human carcinomas. (PMID: 17420726) Zisman-Rozen S. … Ron D. (Oncogene 2007) 3 23
  5. IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling. (PMID: 19079364) Rong Z. … Chang Z. (Cell Res. 2009) 3 23

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