Aliases for IL17RD Gene
External Ids for IL17RD Gene
This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin (PMID: 19079364). The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling (PMID: 21663947, 18096367). [provided by RefSeq, Nov 2011]
GeneCards Summary for IL17RD Gene
IL17RD (Interleukin 17 Receptor D) is a Protein Coding gene. Diseases associated with IL17RD include hypogonadotropic hypogonadism 18 with or without anosmia and kallmann syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR.
UniProtKB/Swiss-Prot for IL17RD Gene
Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity).