Aliases for IL17RC Gene
External Ids for IL17RC Gene
Previous GeneCards Identifiers for IL17RC Gene
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
GeneCards Summary for IL17RC Gene
IL17RC (Interleukin 17 Receptor C) is a Protein Coding gene. Diseases associated with IL17RC include Candidiasis, Familial, 9 and Chronic Mucocutaneous Candidiasis. Among its related pathways are Akt Signaling and Cytokine production by Th17 cells in CF (Mouse model). GO annotations related to this gene include interleukin-17 receptor activity.
UniProtKB/Swiss-Prot for IL17RC Gene
Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Activation of IL17RC leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1 (PubMed:16785495).
Isoform 5: Receptor for both IL17A and IL17F.
Isoform 6: Does not bind IL17A or IL17F.
Isoform 7: Does not bind IL17A or IL17F.
Isoform 8: Receptor for both IL17A and IL17F.