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Aliases for IL17RC Gene

Aliases for IL17RC Gene

  • Interleukin 17 Receptor C 2 3
  • Interleukin-17 Receptor-Like Protein 3 4
  • Interleukin-17 Receptor Homolog 3 4
  • IL-17 Receptor C 3 4
  • IL17Rhom 3 4
  • ZcytoR14 3 4
  • IL-17RL 3 4
  • IL17RL 3 6
  • Interleukin-17 Receptor C 3
  • IL17F Receptor 3
  • IL17-RL 3
  • IL-17RC 4

External Ids for IL17RC Gene

Previous GeneCards Identifiers for IL17RC Gene

  • GC03P009950
  • GC03P009933
  • GC03P009958
  • GC03P009895

Summaries for IL17RC Gene

Entrez Gene Summary for IL17RC Gene

  • This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]

GeneCards Summary for IL17RC Gene

IL17RC (Interleukin 17 Receptor C) is a Protein Coding gene. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include interleukin-17 receptor activity.

Gene Wiki entry for IL17RC Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17RC Gene

Genomics for IL17RC Gene

Regulatory Elements for IL17RC Gene

Transcription factor binding sites by QIAGEN in the IL17RC gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IL17RC Gene

9,917,074 bp from pter
9,933,630 bp from pter
16,557 bases
Plus strand

Genomic View for IL17RC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL17RC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17RC Gene

Proteins for IL17RC Gene

  • Protein details for IL17RC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-17 receptor C
    Protein Accession:
    Secondary Accessions:
    • E9PHG1
    • E9PHJ6
    • Q6UVY3
    • Q6UWD4
    • Q8NFS1
    • Q9BR97

    Protein attributes for IL17RC Gene

    791 amino acids
    Molecular mass:
    86240 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IL17RC Gene

neXtProt entry for IL17RC Gene

Proteomics data for IL17RC Gene at MOPED

Post-translational modifications for IL17RC Gene

  • Ubiquitination at Lys572
  • Glycosylation at Asn189, Asn257, Asn284, Asn297, Asn324, Asn334, Asn420, Asn443, and Asn477
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for IL17RC Gene

Domains for IL17RC Gene

Gene Families for IL17RC Gene

Protein Domains for IL17RC Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SEFIR domain.
  • Contains 1 SEFIR domain.
genes like me logo Genes that share domains with IL17RC: view

Function for IL17RC Gene

Molecular function for IL17RC Gene

UniProtKB/Swiss-Prot Induction:
By HGF and VEGF.

Gene Ontology (GO) - Molecular Function for IL17RC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0030368 interleukin-17 receptor activity IDA 17911633
genes like me logo Genes that share ontologies with IL17RC: view

Phenotypes for IL17RC Gene

genes like me logo Genes that share phenotypes with IL17RC: view

Animal Model Products

miRNA for IL17RC Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL17RC

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IL17RC Gene

Localization for IL17RC Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17RC Gene

Cell membrane; Single-pass type I membrane protein. Note=Soluble isoforms may be produced.

Subcellular locations from

Jensen Localization Image for IL17RC Gene COMPARTMENTS Subcellular localization image for IL17RC gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL17RC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with IL17RC: view

Pathways for IL17RC Gene

genes like me logo Genes that share pathways with IL17RC: view

Pathways by source for IL17RC Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for IL17RC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019221 cytokine-mediated signaling pathway IDA 17911633
GO:1900017 positive regulation of cytokine production involved in inflammatory response IEA --
genes like me logo Genes that share ontologies with IL17RC: view

Transcripts for IL17RC Gene

Unigene Clusters for IL17RC Gene

Interleukin 17 receptor C:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL17RC

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL17RC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - -
SP6: -
SP7: - - - -
SP9: - - - -
SP10: - - -
SP11: - - - -
SP13: -

ExUns: 17a · 17b · 17c

Relevant External Links for IL17RC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL17RC Gene

mRNA expression in normal human tissues for IL17RC Gene

SOURCE GeneReport for Unigene cluster for IL17RC Gene Hs.129959

mRNA Expression by UniProt/SwissProt for IL17RC Gene

Tissue specificity: Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate. Low expression in thymus and leukocytes. Expressed (at protein level) in prostate and prostate cancer, skeletal muscle, kidney and placenta.
genes like me logo Genes that share expressions with IL17RC: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for IL17RC Gene

Orthologs for IL17RC Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17RC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IL17RC 35
  • 84.1 (n)
  • 79.49 (a)
IL17RC 36
  • 78 (a)
(Canis familiaris)
Mammalia IL17RC 35
  • 84.47 (n)
  • 80.61 (a)
IL17RC 36
  • 81 (a)
(Mus musculus)
Mammalia Il17rc 35
  • 77.13 (n)
  • 70.04 (a)
Il17rc 16
Il17rc 36
  • 68 (a)
(Pan troglodytes)
Mammalia IL17RC 35
  • 98.77 (n)
  • 98.86 (a)
IL17RC 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Il17rc 35
  • 77.42 (n)
  • 72.07 (a)
(Monodelphis domestica)
Mammalia IL17RC 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia IL17RC 36
  • 61 (a)
(Gallus gallus)
Aves LOC101750586 35
  • 53.95 (n)
  • 45.23 (a)
IL17RC 36
  • 42 (a)
(Anolis carolinensis)
Reptilia IL17RC 36
  • 36 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486154 35
  • 44.94 (n)
  • 32.21 (a)
Species with no ortholog for IL17RC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL17RC Gene

Gene Tree for IL17RC (if available)
Gene Tree for IL17RC (if available)

Paralogs for IL17RC Gene

No data available for Paralogs for IL17RC Gene

Variants for IL17RC Gene

Sequence variations from dbSNP and Humsavar for IL17RC Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs279544 -- 9,931,502(+) ATATA(C/T)ACTTA intron-variant
rs279545 -- 9,930,809(+) GCTGG(A/G)AATTT intron-variant
rs279546 -- 9,929,085(+) cgagg(A/C)gggca intron-variant
rs279547 -- 9,928,758(+) actgc(C/T)tactt intron-variant
rs279548 -- 9,928,474(+) GAGAA(C/T)GTCAC reference, synonymous-codon, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for IL17RC Gene

Variant ID Type Subtype PubMed ID
nsv834615 CNV Loss 17160897

Relevant External Links for IL17RC Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17RC Gene

Disorders for IL17RC Gene

(2) Novoseek inferred disease relationships for IL17RC Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 22 10
cancer 0 2
genes like me logo Genes that share disorders with IL17RC: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for IL17RC Gene

Publications for IL17RC Gene

  1. Soluble and transmembrane isoforms of novel interleukin-17 receptor- like protein by RNA splicing and expression in prostate cancer. (PMID: 11706037) Haudenschild D. … Reddi A.H. (J. Biol. Chem. 2002) 2 3 4
  2. Generation of interleukin-17 receptor-like protein (IL-17RL) in prostate by alternative splicing of RNA. (PMID: 16688746) Haudenschild D.R. … Reddi A.H. (Prostate 2006) 3 23
  3. IL-17 contributes to angiogenesis in rheumatoid arthritis. (PMID: 20173024) Pickens S.R. … Shahrara S. (J. Immunol. 2010) 3 23
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Using gene expression profiling to identify the molecular basis of the synergistic actions of hepatocyte growth factor and vascular endothelial growth factor in human endothelial cells. (PMID: 14504135) Gerritsen M.E. … Hwang S. (Br. J. Pharmacol. 2003) 3 4

Products for IL17RC Gene

Sources for IL17RC Gene

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