Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IL17RC Gene

Aliases for IL17RC Gene

  • Interleukin 17 Receptor C 2 3 5
  • Interleukin-17 Receptor-Like Protein 3 4
  • Interleukin-17 Receptor Homolog 3 4
  • IL-17 Receptor C 3 4
  • ZcytoR14 3 4
  • IL17Rhom 3 4
  • IL-17RL 3 4
  • Interleukin-17 Receptor C 3
  • IL17F Receptor 3
  • IL17-RL 3
  • IL-17RC 4
  • CANDF9 3
  • IL17RL 3

External Ids for IL17RC Gene

Previous GeneCards Identifiers for IL17RC Gene

  • GC03P009950
  • GC03P009933
  • GC03P009958
  • GC03P009895

Summaries for IL17RC Gene

Entrez Gene Summary for IL17RC Gene

  • This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]

GeneCards Summary for IL17RC Gene

IL17RC (Interleukin 17 Receptor C) is a Protein Coding gene. Diseases associated with IL17RC include Candidiasis, Familial, 9 and Chronic Mucocutaneous Candidiasis. Among its related pathways are IL-17 Family Signaling Pathways and Immune System. GO annotations related to this gene include interleukin-17 receptor activity.

UniProtKB/Swiss-Prot for IL17RC Gene

  • Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Activation of IL17RC leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1 (PubMed:16785495).

  • Isoform 5: Receptor for both IL17A and IL17F.

  • Isoform 6: Does not bind IL17A or IL17F.

  • Isoform 7: Does not bind IL17A or IL17F.

  • Isoform 8: Receptor for both IL17A and IL17F.

Gene Wiki entry for IL17RC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17RC Gene

Genomics for IL17RC Gene

Regulatory Elements for IL17RC Gene

Enhancers for IL17RC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F009861 1.1 FANTOM5 Ensembl ENCODE 37.3 -53.4 -53379 5.0 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZNF143 KLF13 IL17RC JAGN1 CIDEC TADA3 IL17RE ARPC4 RNU6-882P TTLL3 ARPC4-TTLL3 CAMK1
GH03F009883 1.4 FANTOM5 Ensembl ENCODE 34 -32.7 -32683 2.2 PKNOX1 GTF3C2 GATA2 FOS ZNF263 JUNB SMARCB1 SMARCA4 PBX2 STAT3 CIDEC IL17RC JAGN1 RAD18 EMC3-AS1 GHRLOS ENSG00000269982 FANCD2 TATDN2 LINC00852
GH03F009914 1.1 ENCODE 28.8 -0.7 -685 4.1 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF207 FOS IL17RC IL17RE
GH03F009912 1 Ensembl ENCODE 28.2 -4.6 -4574 1.0 HDAC1 ATF1 PKNOX1 TBL1XR1 FEZF1 YY1 ZNF121 GATA2 SCRT2 FOS IL17RC IL17RE
GH03F009896 0.8 Ensembl ENCODE 26.2 -16.9 -16867 8.2 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YBX1 YY1 SLC30A9 CBX5 RAD18 THUMPD3-AS1 IL17RC GHRLOS JAGN1 ENSG00000269982 CRELD1 PRRT3-AS1 CYCSP10 FANCD2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IL17RC on UCSC Golden Path with GeneCards custom track

Promoters for IL17RC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001844978 226 1001 HDGF ATF1 PKNOX1 ARID4B SIN3A YY1 GLIS2 ZNF207 ZNF263 SP3

Genomic Location for IL17RC Gene

Chromosome:
3
Start:
9,917,074 bp from pter
End:
9,933,630 bp from pter
Size:
16,557 bases
Orientation:
Plus strand

Genomic View for IL17RC Gene

Genes around IL17RC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17RC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17RC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17RC Gene

Proteins for IL17RC Gene

  • Protein details for IL17RC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAC3-I17RC_HUMAN
    Recommended name:
    Interleukin-17 receptor C
    Protein Accession:
    Q8NAC3
    Secondary Accessions:
    • A8BWC1
    • A8BWC9
    • A8BWD5
    • E9PHG1
    • E9PHJ6
    • Q6UVY3
    • Q6UWD4
    • Q8NFS1
    • Q9BR97

    Protein attributes for IL17RC Gene

    Size:
    791 amino acids
    Molecular mass:
    86240 Da
    Quaternary structure:
    • Heterodimer with IL17RA (PubMed:16785495, PubMed:18684971). Heterodimerization with IL17RA is independent of the cytoplasmic tail (By similarity). Associates with non-glycosylated IL17RA constitutively (By similarity). Binding of IL17A and IL17F induces association with glycosylated IL17RA (By similarity). Interacts (via SEFIR domain and extended downstream region) with TRAF3IP2/ACT1 (phosphorylated) (By similarity).

    Alternative splice isoforms for IL17RC Gene

neXtProt entry for IL17RC Gene

Post-translational modifications for IL17RC Gene

  • Ubiquitination at Lys 572
  • Glycosylation at Asn 189, Asn 257, Asn 284, Asn 297, Asn 324, Asn 334, Asn 420, Asn 443, and Asn 477
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for IL17RC
  • Cloud-Clone Corp. Antibodies for IL17RC

No data available for DME Specific Peptides for IL17RC Gene

Domains & Families for IL17RC Gene

Gene Families for IL17RC Gene

Protein Domains for IL17RC Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8NAC3

UniProtKB/Swiss-Prot:

I17RC_HUMAN :
  • Contains 1 SEFIR domain.
Domain:
  • Contains 1 SEFIR domain.
genes like me logo Genes that share domains with IL17RC: view

Function for IL17RC Gene

Molecular function for IL17RC Gene

UniProtKB/Swiss-Prot Function:
Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Activation of IL17RC leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1 (PubMed:16785495).
UniProtKB/Swiss-Prot Function:
Isoform 5: Receptor for both IL17A and IL17F.
UniProtKB/Swiss-Prot Function:
Isoform 6: Does not bind IL17A or IL17F.
UniProtKB/Swiss-Prot Function:
Isoform 7: Does not bind IL17A or IL17F.
UniProtKB/Swiss-Prot Function:
Isoform 8: Receptor for both IL17A and IL17F.
UniProtKB/Swiss-Prot Induction:
By HGF and VEGF.

Gene Ontology (GO) - Molecular Function for IL17RC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0030368 interleukin-17 receptor activity IDA 17911633
genes like me logo Genes that share ontologies with IL17RC: view

Phenotypes for IL17RC Gene

genes like me logo Genes that share phenotypes with IL17RC: view

Human Phenotype Ontology for IL17RC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL17RC Gene

MGI Knock Outs for IL17RC:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL17RC

miRNA for IL17RC Gene

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL17RC Gene

Localization for IL17RC Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17RC Gene

Cell membrane; Single-pass type I membrane protein. Note=Soluble isoforms may be produced.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL17RC Gene COMPARTMENTS Subcellular localization image for IL17RC gene
Compartment Confidence
plasma membrane 4
cytoskeleton 3
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL17RC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL17RC: view

Pathways & Interactions for IL17RC Gene

genes like me logo Genes that share pathways with IL17RC: view

Gene Ontology (GO) - Biological Process for IL17RC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019221 cytokine-mediated signaling pathway IEA --
GO:0050832 defense response to fungus IEA --
GO:0071621 granulocyte chemotaxis IEA --
GO:1900017 positive regulation of cytokine production involved in inflammatory response IEA --
GO:2000778 positive regulation of interleukin-6 secretion IEA --
genes like me logo Genes that share ontologies with IL17RC: view

No data available for SIGNOR curated interactions for IL17RC Gene

Transcripts for IL17RC Gene

Unigene Clusters for IL17RC Gene

Interleukin 17 receptor C:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL17RC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - -
SP6: -
SP7: - - - -
SP8:
SP9: - - - -
SP10: - - -
SP11: - - - -
SP12:
SP13: -

ExUns: 17a · 17b · 17c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for IL17RC Gene

GeneLoc Exon Structure for
IL17RC
ECgene alternative splicing isoforms for
IL17RC

Expression for IL17RC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL17RC Gene

NURSA nuclear receptor signaling pathways regulating expression of IL17RC Gene:

IL17RC

SOURCE GeneReport for Unigene cluster for IL17RC Gene:

Hs.129959

mRNA Expression by UniProt/SwissProt for IL17RC Gene:

Q8NAC3-I17RC_HUMAN
Tissue specificity: Expressed in prostate, skeletal muscle, kidney and placenta (at protein level) (PubMed:11706037). Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate (PubMed:11706037). Also detected in thyroid, trachea and adrenal gland (PubMed:17911633). Low expression in thymus and leukocytes (PubMed:11706037).
genes like me logo Genes that share expression patterns with IL17RC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for IL17RC Gene

Orthologs for IL17RC Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17RC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL17RC 34 35
  • 98.77 (n)
dog
(Canis familiaris)
Mammalia IL17RC 34 35
  • 84.47 (n)
cow
(Bos Taurus)
Mammalia IL17RC 34 35
  • 84.1 (n)
rat
(Rattus norvegicus)
Mammalia Il17rc 34
  • 77.42 (n)
mouse
(Mus musculus)
Mammalia Il17rc 34 16 35
  • 77.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IL17RC 35
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL17RC 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101750586 34
  • 53.95 (n)
IL17RC 35
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL17RC 35
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486154 34
  • 44.94 (n)
Species where no ortholog for IL17RC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL17RC Gene

ENSEMBL:
Gene Tree for IL17RC (if available)
TreeFam:
Gene Tree for IL17RC (if available)

Paralogs for IL17RC Gene

No data available for Paralogs for IL17RC Gene

Variants for IL17RC Gene

Sequence variations from dbSNP and Humsavar for IL17RC Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1056286 -- 9,915,771(+) CGGCT(C/T)GAACG nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, reference, synonymous-codon, utr-variant-3-prime
rs1091856 -- 9,921,207(+) cccag(A/T)acttt intron-variant
rs1092374 -- 9,921,860(+) gacct(C/T)gtgat intron-variant
rs1092375 -- 9,921,904(+) acagg(C/T)gtgag intron-variant
rs1092517 -- 9,921,809(+) tttag(C/T)agaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL17RC Gene

Variant ID Type Subtype PubMed ID
nsv589648 CNV loss 21841781
nsv834615 CNV loss 17160897

Variation tolerance for IL17RC Gene

Residual Variation Intolerance Score: 79.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.62; 78.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL17RC Gene

Human Gene Mutation Database (HGMD)
IL17RC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL17RC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17RC Gene

Disorders for IL17RC Gene

MalaCards: The human disease database

(4) MalaCards diseases for IL17RC Gene - From: OMIM, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
candidiasis, familial, 9
  • candf9
chronic mucocutaneous candidiasis
  • cmc
candidiasis
  • disseminated candidiasis
macular degeneration, age-related, 1
  • macular degeneration, age-related, reduced risk of
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

I17RC_HUMAN
  • Candidiasis, familial, 9 (CANDF9) [MIM:616445]: A disorder characterized by altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269 PubMed:25918342}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IL17RC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL17RC
genes like me logo Genes that share disorders with IL17RC: view

No data available for Genatlas for IL17RC Gene

Publications for IL17RC Gene

  1. Soluble and transmembrane isoforms of novel interleukin-17 receptor- like protein by RNA splicing and expression in prostate cancer. (PMID: 11706037) Haudenschild D. … Reddi A.H. (J. Biol. Chem. 2002) 2 3 4 64
  2. Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. (PMID: 25918342) Ling Y. … Puel A. (J. Exp. Med. 2015) 3 4 64
  3. IL-17 contributes to angiogenesis in rheumatoid arthritis. (PMID: 20173024) Pickens S.R. … Shahrara S. (J. Immunol. 2010) 3 22 64
  4. The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex. (PMID: 18684971) Wright J.F. … Carreno B.M. (J. Immunol. 2008) 3 4 64
  5. Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. (PMID: 17911633) Kuestner R.E. … Levin S.D. (J. Immunol. 2007) 3 4 64

Products for IL17RC Gene

Sources for IL17RC Gene

Content
Loading form....