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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL17RC Gene

protein-coding   GIFtS: 54
GCID: GC03P009958

Interleukin 17 Receptor C

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Interleukin 17 Receptor C1 2     IL17-RL2
Interleukin-17 Receptor Homolog2 3     IL17F Receptor2
Interleukin-17 Receptor-Like Protein2 3     Interleukin-17 Receptor C2
IL-17RL2 3     zcytoR142
IL17Rhom2 3     IL-17RC3
IL-17 Receptor C2 3     ZcytoR143
IL17RL2 5     

External Ids:    HGNC: 183581   Entrez Gene: 848182   Ensembl: ENSG000001637027   OMIM: 6109255   UniProtKB: Q8NAC33   
ORGUL members:         
NONCODE14:n410568      

Export aliases for IL17RC gene to outside databases

Previous GC identifers: GC03P009950 GC03P009933 GC03P009895


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL17RC Gene:
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor
(IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to
only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar
affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of
inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different
isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking
transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.
(provided by RefSeq, Feb 2011)

GeneCards Summary for IL17RC Gene: 
IL17RC (interleukin 17 receptor C) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with IL17RC include scoliosis, and osteoarthritis, and among its related super-pathways are Mucin expression in CF via IL-6, IL-17 signaling pathways and MAPK Family Pathway. GO annotations related to this gene include interleukin-17 receptor activity.

Gene Wiki entry for IL17RC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL17RC gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL17RC promoter sequence
   Search SABiosciences Chromatin IP Primers for IL17RC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL17RC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.3|3p25.3-p24.1   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25.3

IL17RC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL17RC gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P009958:  view genomic region     (about GC identifiers)

Start:
9,958,758 bp from pter      End:
9,975,314 bp from pter
Size:
16,557 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: I17RC_HUMAN, Q8NAC3 (See protein sequence)
Recommended Name: Interleukin-17 receptor C precursor  
Size: 791 amino acids; 86240 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Soluble isoforms may be produced
Secondary accessions: E9PHG1 E9PHJ6 Q6UVY3 Q6UWD4 Q8NFS1 Q9BR97
Alternative splicing: 6 isoforms:  Q8NAC3-1   Q8NAC3-2   Q8NAC3-3   Q8NAC3-4   Q8NAC3-5   Q8NAC3-6   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for IL17RC: NX_Q8NAC3

Explore proteomics data for IL17RC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NAC3

  • IL17RC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL17RC Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001190192.1  NP_001190193.1  NP_001190194.1  NP_116121.2  NP_703190.1  NP_703191.1  

    ENSEMBL proteins: 
     ENSP00000373323   ENSP00000387675   ENSP00000394996   ENSP00000414609   ENSP00000399396  
     ENSP00000295981   ENSP00000410834   ENSP00000401128   ENSP00000384969   ENSP00000432564  
     ENSP00000412777   ENSP00000390080   ENSP00000413914   ENSP00000407894   ENSP00000396064  
     ENSP00000395315  

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    Cloud-Clone Corp. Proteins for IL17RC 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    IL17RC for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: interleukin 17 receptor C 
    IL-17 receptor family

    1 InterPro protein domain:
     IPR013568 SEFIR

    Graphical View of Domain Structure for InterPro Entry Q8NAC3

    ProtoNet protein and cluster: Q8NAC3

    1 Blocks protein domain: IPB013568 SEFIR

    UniProtKB/Swiss-Prot: I17RC_HUMAN, Q8NAC3
    Similarity: Contains 1 SEFIR domain


    IL17RC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I17RC_HUMAN, Q8NAC3
    Induction: By HGF and VEGF

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0030368interleukin-17 receptor activity IDA17911633
         
    IL17RC for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il17rc):
     homeostasis/metabolism  immune system  normal 

    IL17RC for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL17RC About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Mucin expression in CF via IL-6, IL-17 signaling pathways
    Mucin expression in CF via IL-6, IL-17 signaling pathways0.48
    IL-17 Signaling0.48
    2TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4PEDF Induced Signaling
    PGC1Alpha Pathway0.51
    Glucocorticoid Receptor Signaling0.43
    STAT3 Pathway0.47
    5Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF0.72
    Cytokine production by Th17 cells in CF (Mouse model)0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL17RC
        IL-17 Signaling

    5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL17RC (see all 12)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Glucocorticoid Receptor Signaling
    JAK-STAT Pathway

    3 GeneGo (Thomson Reuters) Pathways for IL17RC
        Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF
    Mucin expression in CF via IL-6, IL-17 signaling pathways



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL17RC

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for IL17RC (Q8NAC33 ENSP000002959814) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL17AQ165523, ENSP000003441924I2D: score=1 STRING: ENSP00000344192
    IL17RAQ96F463, ENSP000003209364I2D: score=1 STRING: ENSP00000320936
    IL17FQ96PD43, ENSP000003374324I2D: score=1 STRING: ENSP00000337432
    TRAF3IP2ENSP000003459844STRING: ENSP00000345984
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:1900017positive regulation of cytokine production involved in inflammatory response IEA--

    IL17RC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL17RC (I17RC)

    Search CenterWatch for drugs/clinical trials and news about IL17RC / I17RC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL17RC gene (8 alternative transcripts): 
    NM_001203263.1  NM_001203264.1  NM_001203265.1  NM_032732.5  NM_153460.3  NM_153461.3  NM_153462.1  NM_153463.1  

    Unigene Cluster for IL17RC:

    Interleukin 17 receptor C
    Hs.129959  [show with all ESTs]
    Unigene Representative Sequence: NM_153461
    18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000383812(uc011atp.2 uc003bub.3 uc010hcv.3) ENST00000469686
    ENST00000451165(uc010hcr.3) ENST00000434756 ENST00000438091 ENST00000412901
    ENST00000466046(uc011ato.2) ENST00000295981(uc010hcs.3 uc003btz.3 uc010hct.3 uc010hcu.3 uc003buc.3 uc003bua.3)
    ENST00000451231 ENST00000483582(uc011atq.2) ENST00000481032 ENST00000497102
    ENST00000494365 ENST00000498214(uc003bud.3) ENST00000436503 ENST00000403601
    ENST00000476810 ENST00000451271
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    Additional mRNA sequence: 

    AF458065.1 AK092907.1 AK094746.1 AK225650.1 AK290670.1 AK294616.1 AK303171.1 AK308241.1 
    AK315053.1 AY358840.1 AY359098.1 BC128512.1 EF676032.1 EF676033.1 EF676034.1 NR_037807.1 

    24/28 DOTS entries (see all 28):

    DT.101985079  DT.402620  DT.100811649  DT.97859799  DT.91724064  DT.100811648  DT.95359559  DT.99985811 
    DT.100811638  DT.120895783  DT.95359557  DT.97859798  DT.100030695  DT.100811639  DT.120896025  DT.86847073 
    DT.100811645  DT.100811653  DT.120895775  DT.75103630  DT.100811643  DT.120895801  DT.120895896  DT.444495 

    24/227 AceView cDNA sequences (see all 227):

    CB069702 CA487323 NM_032732 BQ214787 NM_153462 BI764608 BQ067422 BX337286 
    NM_153460 CF272286 AI283200 BI767178 AW517227 NM_153463 BX339026 BQ879033 
    AI983969 NM_153461 CD671106 BM353190 AI361637 AI093316 BI756537 BI753674 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for IL17RC (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
    SP1:              -                       -                                   -     -     -                                                                     
    SP2:              -                       -           -                       -     -     -                                                                     
    SP3:              -                       -           -                       -     -     -                                                                     
    SP4:              -                       -           -                             -     -                                   -     -     -                     
    SP5:                                      -                                         -     -                                                                     

    ExUns: 17a · 17b · 17c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for IL17RC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL17RC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAAATACA
    IL17RC Expression
    About this image


    See IL17RC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL17RC

    SOURCE GeneReport for Unigene cluster: Hs.129959

    UniProtKB/Swiss-Prot: I17RC_HUMAN, Q8NAC3
    Tissue specificity: Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta,
    and prostate. Low expression in thymus and leukocytes. Expressed (at protein level) in prostate and prostate
    cancer, skeletal muscle, kidney and placenta

        SABiosciences Expression via Pathway-Focused PCR Array including IL17RC: 
              Th17 Response in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17RC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL17RC gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il17rc1 , 5 interleukin 17 receptor C1, 5 77.86(n)1
    71.03(a)1
      6 (52.77 cM)5
    1710951  NM_178942.11  NP_849273.11 
     1134714275 
    chicken
    (Gallus gallus)
    Aves IL17RC6
    interleukin 17 receptor C
    40(a)
    1 ↔ 1
    AADN03014429.1(21-1477)
    lizard
    (Anolis carolinensis)
    Reptilia IL17RC6
    interleukin 17 receptor C
    36(a)
    1 ↔ 1
    2(191414205-191463572)
    zebrafish
    (Danio rerio)
    Actinopterygii CU179703.16
    Uncharacterized protein
    14(a)
    1 → many
    25(30464134-30489505)


    ENSEMBL Gene Tree for IL17RC (if available)
    TreeFam Gene Tree for IL17RC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/589 SNPs in IL17RC are shown (see all 589)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1120931451,2
    C,F--9891574(+) ACCAAC/GCCCCA 7 -- us2k12Minor allele frequency- G:0.03CSA WA 120
    rs6938021,2
    C,F,A--9891665(+) CAGTCC/TCTCAG 7 -- us2k16Minor allele frequency- T:0.47NA CSA WA 245
    rs1119490481,2
    C--9891688(+) CATCTG/TTTGCT 7 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs2005211881,2
    C--9891804(+) CAGCGA/CTGGGC 7 -- us2k10--------
    rs1125434091,2
    C--9892152(+) CTTTCA/GCAGAG 7 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs10562861,2
    C,F,A--9892226(+) CGGCTC/TGAACG 7 -- us2k17Minor allele frequency- T:0.47MN NA CSA WA EA EU 1051
    rs1870974091,2
    --9892324(+) GGAACC/TCCGGA 7 -- us2k10--------
    rs1124180761,2
    C,F--9892334(+) AATGAG/TCCTTC 7 -- us2k12Minor allele frequency- T:0.03CSA WA 120
    rs1122903801,2
    C--9892434(+) GCGCGC/AGTCCC 7 -- us2k12Minor allele frequency- A:0.03CSA WA 120
    rs1499321671,2
    C--9892579(+) TTGGGA/GCCGGG 7 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL17RC (9958758 - 9975314 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL17RC:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834615CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610925    OMIM disorders: --

    5 diseases for IL17RC:    About MalaCards
    scoliosis    osteoarthritis    prostate cancer    prostatitis
    endotheliitis


    IL17RC for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for IL17RC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 22 12 16397230 (7), 17603628 (3)
    cancer 0 2 16688746 (2)


    Export disorders for IL17RC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL17RC gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with IL17RC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Soluble and transmembrane isoforms of novel interleukin-17 receptor- like protein by RNA splicing and expression in prostate cancer. (PubMed id 11706037)1, 2, 3 Haudenschild D.... Reddi A.H. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    5. Using gene expression profiling to identify the molecular basis of the synergistic actions of hepatocyte growth factor and vascular endothelial growth factor in human endothelial cells. (PubMed id 14504135)1, 2 Gerritsen M.E.... Hwang S. (2003)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Generation of interleukin-17 receptor-like protein (IL-17RL) in prostate by alternative splicing of RNA. (PubMed id 16688746)1, 9 Haudenschild D.R....Reddi A.H. (2006)
    8. IL-17 contributes to angiogenesis in rheumatoid arthr itis. (PubMed id 20173024)1, 9 Pickens S.R....Shahrara S. (2010)
    9. Th17-associated cytokines promote human airway smooth muscle cell proliferation. (PubMed id 22898922)1 Chang Y....Hamid Q. (2012)
    10. A single-nucleotide polymorphism rs708567 in the IL-17 RC gene is associated with a susceptibility to and the curve severity of adolesc ent idiopathic scoliosis in a Chinese Han population: a case-control study. (PubMed id 22999050)1 Zhou S....Qiu Y. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84818 HGNC: 18358 AceView: IL17RC Ensembl:ENSG00000163702 euGenes: HUgn84818
    ECgene: IL17RC H-InvDB: IL17RC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL17RC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL17RC gene:
    Search GeneIP for patents involving IL17RC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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