Aliases for IL17RC Gene
External Ids for IL17RC Gene
Previous GeneCards Identifiers for IL17RC Gene
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
GeneCards Summary for IL17RC Gene
IL17RC (Interleukin 17 Receptor C) is a Protein Coding gene. Diseases associated with IL17RC include candidiasis, familial, 9 and chronic mucocutaneous candidosis. Among its related pathways are Akt Signaling and PAK Pathway. GO annotations related to this gene include interleukin-17 receptor activity.