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Aliases for IL17RB Gene

Aliases for IL17RB Gene

  • Interleukin 17 Receptor B 2 3
  • IL17RH1 3 4 6
  • IL17BR 3 4 6
  • Interleukin 17B Receptor 2 3
  • Cytokine Receptor-Like 4 3 4
  • Interleukin-17B Receptor 3 4
  • IL-17 Receptor Homolog 1 3 4
  • IL-17 Receptor B 3 4
  • IL-17B Receptor 3 4
  • IL-17Rh1 3 4
  • IL-17RB 3 4
  • EVI27 3 4
  • CRL4 3 4
  • Interleukin 17 Receptor Homolog 1 3
  • Interleukin-17 Receptor B 3
  • Cytokine Receptor CRL4 3

External Ids for IL17RB Gene

Previous Symbols for IL17RB Gene

  • IL17BR

Summaries for IL17RB Gene

Entrez Gene Summary for IL17RB Gene

  • The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL17RB Gene

IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. Among its related pathways are IL-17 Family Signaling Pathways and IL-17 Family Signaling Pathways. GO annotations related to this gene include cytokine receptor activity. An important paralog of this gene is IL17RA.

UniProtKB/Swiss-Prot for IL17RB Gene

  • Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.

Gene Wiki entry for IL17RB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17RB Gene

Genomics for IL17RB Gene

Genomic Location for IL17RB Gene

Start:
53,846,550 bp from pter
End:
53,865,800 bp from pter
Size:
19,251 bases
Orientation:
Plus strand

Genomic View for IL17RB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL17RB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17RB Gene

Regulatory Elements for IL17RB Gene

Proteins for IL17RB Gene

  • Protein details for IL17RB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRM6-I17RB_HUMAN
    Recommended name:
    Interleukin-17 receptor B
    Protein Accession:
    Q9NRM6
    Secondary Accessions:
    • Q9BPZ0
    • Q9NRL4
    • Q9NRM5

    Protein attributes for IL17RB Gene

    Size:
    502 amino acids
    Molecular mass:
    55885 Da
    Quaternary structure:
    • Interacts with DAZAP2.

    Alternative splice isoforms for IL17RB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL17RB Gene

Proteomics data for IL17RB Gene at MOPED

Post-translational modifications for IL17RB Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn67, Asn103, Asn156, Asn183, Asn197, and Asn283

Other Protein References for IL17RB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL17RB Gene

Domains for IL17RB Gene

Gene Families for IL17RB Gene

HGNC:
  • IL :Interleukins and interleukin receptors
IUPHAR :

Protein Domains for IL17RB Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

I17RB_HUMAN
Domain:
  • Contains 1 SEFIR domain.:
    • Q9NRM6
genes like me logo Genes that share domains with IL17RB: view

Function for IL17RB Gene

Molecular function for IL17RB Gene

UniProtKB/Swiss-Prot Function: Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.

Gene Ontology (GO) - Molecular Function for IL17RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity NAS 10815801
GO:0030368 interleukin-17 receptor activity IBA --
genes like me logo Genes that share ontologies with IL17RB: view
genes like me logo Genes that share phenotypes with IL17RB: view

Animal Models for IL17RB Gene

MGI Knock Outs for IL17RB:

miRNA for IL17RB Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL17RB Gene

Localization for IL17RB Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17RB Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL17RB Gene COMPARTMENTS Subcellular localization image for IL17RB gene
Compartment Confidence
extracellular 5
plasma membrane 5
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL17RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0009986 cell surface IEA --
GO:0016020 membrane NAS 10815801
genes like me logo Genes that share ontologies with IL17RB: view

Pathways for IL17RB Gene

genes like me logo Genes that share pathways with IL17RB: view

Pathways by source for IL17RB Gene

1 R&D Systems pathway for IL17RB Gene
1 BioSystems pathway for IL17RB Gene
1 KEGG pathway for IL17RB Gene

Gene Ontology (GO) - Biological Process for IL17RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 10815801
GO:0006952 defense response TAS 10749887
GO:0019221 cytokine-mediated signaling pathway NAS 10815801
genes like me logo Genes that share ontologies with IL17RB: view

Transcripts for IL17RB Gene

Unigene Clusters for IL17RB Gene

Interleukin 17 receptor B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL17RB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
SP1: - - -
SP2:
SP3: -
SP4: -

Relevant External Links for IL17RB Gene

GeneLoc Exon Structure for
IL17RB
ECgene alternative splicing isoforms for
IL17RB

Expression for IL17RB Gene

mRNA expression in normal human tissues for IL17RB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL17RB Gene

This gene is overexpressed in Kidney - Cortex (11.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IL17RB Gene

SOURCE GeneReport for Unigene cluster for IL17RB Gene Hs.654970

mRNA Expression by UniProt/SwissProt for IL17RB Gene

Q9NRM6-I17RB_HUMAN
Tissue specificity: Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines
genes like me logo Genes that share expressions with IL17RB: view

Orthologs for IL17RB Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17RB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL17RB 36
  • 99.12 (n)
  • 98.37 (a)
IL17RB 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL17RB 36
  • 85.08 (n)
  • 82.52 (a)
IL17RB 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL17RB 36
  • 84.34 (n)
  • 80.82 (a)
IL17RB 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il17rb 36
  • 79.12 (n)
  • 74.95 (a)
Il17rb 16
Il17rb 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL17RB 37
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 60 (a)
OneToMany
-- 37
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Il17rb 36
  • 77.05 (n)
  • 71.39 (a)
lizard
(Anolis carolinensis)
Reptilia IL17RB 37
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii il17ra1 37
  • 12 (a)
OneToOne
Species with no ortholog for IL17RB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL17RB Gene

ENSEMBL:
Gene Tree for IL17RB (if available)
TreeFam:
Gene Tree for IL17RB (if available)

Paralogs for IL17RB Gene

Paralogs for IL17RB Gene

genes like me logo Genes that share paralogs with IL17RB: view

Variants for IL17RB Gene

Sequence variations from dbSNP and Humsavar for IL17RB Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs999514 -- 53,855,822(+) CTCAA(C/T)TTGTG intron-variant, upstream-variant-2KB
rs999515 -- 53,855,954(+) TAATA(C/T)AGTGT intron-variant, upstream-variant-2KB
rs1025689 -- 53,849,695(-) TCTCC(C/G)GGGAT reference, synonymous-codon, nc-transcript-variant
rs1025690 -- 53,848,636(-) CGTCA(C/T)GTTGA intron-variant
rs1134091 -- 53,863,141(-) TGTTA(G/T)GTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL17RB Gene

Variant ID Type Subtype PubMed ID
nsv876803 CNV Loss 21882294
dgv283n21 CNV Loss 19592680
nsv876804 CNV Gain 21882294
nsv876805 CNV Loss 21882294

Relevant External Links for IL17RB Gene

HapMap Linkage Disequilibrium report
IL17RB
Human Gene Mutation Database (HGMD)
IL17RB

Disorders for IL17RB Gene

Relevant External Links for IL17RB

Genetic Association Database (GAD)
IL17RB
Human Genome Epidemiology (HuGE) Navigator
IL17RB
genes like me logo Genes that share disorders with IL17RB: view

No data available for UniProtKB/Swiss-Prot for IL17RB Gene

Publications for IL17RB Gene

  1. Evi27 encodes a novel membrane protein with homology to the IL17 receptor. (PMID: 10815801) Tian E. … Shaughnessy J.D. Jr. (Oncogene 2000) 2 3 4 23
  2. Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance. (PMID: 18794098) Goetz M.P. … Ingle J.N. (Clin. Cancer Res. 2008) 3 23 49
  3. Association of IL-17RB gene polymorphism with asthma. (PMID: 19118269) Jung J.S. … Shin H.D. (Chest 2009) 3 23 49
  4. A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. (PMID: 10749887) Shi Y. … Ebner R. (J. Biol. Chem. 2000) 2 3 4
  5. IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. (PMID: 11058597) Lee J. … Gurney A.L. (J. Biol. Chem. 2001) 3 4

Products for IL17RB Gene

Sources for IL17RB Gene

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