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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL17RB Gene

protein-coding   GIFtS: 55
GCID: GC03P053855

interleukin 17 receptor B

(Previous name: interleukin 17B receptor )
(Previous symbol: IL17BR)
 Explore 13 diseases affiliated with
IL17RB via our new
 Human Malady Compendium 
Biological research products
for IL17RB
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Interleukin 17 Receptor B1 2     IL-17Rh12 3
IL17BR1 2 3 5     IL-17 Receptor B2 3
CRL41 2 3     IL-17 Receptor Homolog 12 3
EVI271 2 3     IL-17B Receptor2 3
IL17RH11 2 5     Cytokine Receptor CRL42
Interleukin 17B Receptor1 2     Interleukin 17 Receptor Homolog 12
Cytokine Receptor-Like 42 3     Interleukin-17 Receptor B2
Interleukin-17B Receptor2 3     IL17Rh13
IL-17RB2 3     

External Ids:    HGNC: 180151   Entrez Gene: 555402   Ensembl: ENSG000000567367   OMIM: 6054585   UniProtKB: Q9NRM63   

Export aliases for IL17RB gene to outside databases

Previous GC identifers: GC03P053735 GC03P053837


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL17RB:
The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does
not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of
IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated
during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: I17RB_HUMAN, Q9NRM6
Function: Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or
differentiation of hematopoietic cells

Gene Wiki entry for IL17RB


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL17RB gene promoter:
         S8   POU2F1   Tal-1beta   ITF-2   NF-kappaB   NF-kappaB1   YY1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL17RB promoter sequence
   Search SABiosciences Chromatin IP Primers for IL17RB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL17RB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p21.1

IL17RB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL17RB gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P053855:  view genomic region     (about GC identifiers)

Start:
53,880,577 bp from pter      End:
53,899,827 bp from pter
Size:
19,251 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: I17RB_HUMAN, Q9NRM6 (See protein sequence)
Recommended Name: Interleukin-17 receptor B precursor  
Size: 502 amino acids; 55885 Da
Subunit: Interacts with DAZAP2
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
Secondary accessions: Q9BPZ0 Q9NRL4 Q9NRM5
Alternative splicing: 2 isoforms:  Q9NRM6-1   Q9NRM6-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for IL17RB: NX_Q9NRM6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NRM6

  • IL17RB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061195.2  
    ENSEMBL proteins: 
     ENSP00000288167   ENSP00000418638  

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    Uscn Proteins for IL17RB

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm IEA--
    GO:0005887integral to plasma membrane TAS10749887
    GO:0009986cell surface IEA--
    GO:0016020membrane NAS10815801


    IL17RB for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    IL17RB for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR013568 SEFIR

    Graphical View of Domain Structure for InterPro Entry Q9NRM6

    ProtoNet protein and cluster: Q9NRM6

    1 Blocks protein family: IPB013568 SEFIR

    UniProtKB/Swiss-Prot: I17RB_HUMAN, Q9NRM6
    Similarity: Contains 1 SEFIR domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: I17RB_HUMAN, Q9NRM6
    Function: Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or
    differentiation of hematopoietic cells

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate IL17RB:
    hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidIL17RB 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004896cytokine receptor activity NAS10815801


    IL17RB for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for IL17RB: Il17rbtm1Anjm Il17rbtm1Bud Il17rbtm1Hwata
         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Il17rb):
     cellular  hematopoietic system  immune system  respiratory system  skeleton 

    IL17RB for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.26

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for IL17RB):
        Cytokine-cytokine receptor interaction


    IL17RB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL17RB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for IL17RB (Q9NRM63 ENSP000002881674) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL25Q9H2933, ENSP000003281114I2D: score=3 STRING: ENSP00000328111
    PCNAP120043, ENSP000003684384I2D: score=1 STRING: ENSP00000368438
    IL17BQ9UHF53, ENSP000002617964I2D: score=3 STRING: ENSP00000261796
    SETD8Q9NQR13, ENSP000003329954I2D: score=1 STRING: ENSP00000332995
    IL17RDQ8NFM73I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth NAS10815801
    GO:0006952defense response TAS10749887
    GO:0019221cytokine-mediated signaling pathway NAS10815801


    IL17RB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL17RB
    Search CenterWatch for drugs/clinical trials and news about IL17RB / I17RB 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL17RB gene (2 alternative transcripts): 
    NM_018725.3  NM_172234.1  

    Unigene Cluster for IL17RB:

    Interleukin 17 receptor B
    Hs.654970  [show with all ESTs]
    Unigene Representative Sequence: NM_018725
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000288167(uc003dha.3) ENST00000475124 ENST00000494338

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate IL17RB:
    hsa-miR-664
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF208110.1 AF212365.1 AF250309.1 AK307749.1 AY359122.1 BC000980.1 

    7 DOTS entries:

    DT.451577  DT.91765740  DT.100787928  DT.95167453  DT.95167455  DT.95167457  DT.307855 

    24/85 AceView cDNA sequences (see all 85):

    BM693867 BX453537 BX483104 AI913613 AA007528 BC000980 NM_172234 CR615594 
    NM_018725 AV660618 AY359122 AV728939 AW673932 BQ226353 AI744263 BE539514 
    CA412162 W61239 AV728945 AF212365 AI032064 AF250309 AI942234 AW970151 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for IL17RB    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
    SP1:                                      -     -     -                                       
    SP2:                                                                                          
    SP3:                                                        -                                 
    SP4:                                                  -                                       


    ECgene alternative splicing isoforms for IL17RB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL17RB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAAGCAAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    IL17RB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSertoli cellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IL17RB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL17RB

    SOURCE GeneReport for Unigene cluster: Hs.654970

    UniProtKB/Swiss-Prot: I17RB_HUMAN, Q9NRM6
    Tissue specificity: Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis,
    colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL17RB: 
              Th17 Response in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17RB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL17RB gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia IL17RB6
    --
    41(a)
    1 ↔ 1
    2(160554727-160567851)
    zebrafish
    (Danio rerio)
    Actinopterygii il17ra16
    BX942819.16
    (see all 5)
    --
    7(a)
    24(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    4(32620151-32622530)
    4(52353406-52355192)


    ENSEMBL Gene Tree for IL17RB (if available)
    TreeFam Gene Tree for IL17RB (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL17RB gene
    IL17RA2  

    IL17RB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/403 NCBI SNPs in IL17RB are shown (see all 403    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887734001,2
    --53882438(+) CACCTA/GTGGTC 1 -- int10--------
    rs1920837181,2
    --53882504(+) GGTCCA/GTCATA 1 -- int10--------
    rs22323331,2
    C,F,--53882661(+) CTTCAA/GCGTGA 1 -- int115Minor allele frequency- G:0.22NS NA WA EU 2294
    rs10256901,2
    C,F,O,A,H,,--53882663(-) CGTCAT/CGTTGA 1 -- int127Minor allele frequency- C:0.22NA EA NS WA CSA EU 3653
    rs114115321,2
    C,--53882673(+) CTTGGT/-TTTTT 1 -- int1 trp31Minor allele frequency- -:0.00CSA 2
    rs2007845721,2
    C--53882673(-) AAAAAA/CCAAGC 1 -- int10--------
    rs58490091,2
    C--53882674(+) TTTTTT/-CTCTC 1 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs1402549231,2
    C,F--53882694(+) AGACCG/ATTCAA 2 /I /V mis11Minor allele frequency- A:0.00NA 4550
    rs76506861,2
    C,--53882795(+) GGCAAT/CAGGTC 1 -- int14Minor allele frequency- C:0.02NS WA 246
    rs22768391,2
    C,F,H,--53882903(+) AGGCCG/CTGTTT 1 -- int125Minor allele frequency- C:0.12EA NS NA WA 3432

    HapMap Linkage Disequilibrium report for IL17RB (53880577 - 53899827 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IL17RB: --
    Human Gene Mutation Database (HGMD): IL17RB

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for IL17RB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IL17RB for disorders           About GeneDecksing

    OMIM gene information: 605458    OMIM disorders: --

    13 diseases for IL17RB:    About MalaCards
    allergic rhinitis    rhinitis    squamous cell carcinoma    rheumatoid arthritis
    hepatitis b    rabies    arthritis    breast cancer
    asthma    hepatitis    esophagitis    adenocarcinoma
    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: IL17RB (9 documents)

    Export disorders for IL17RB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL17RB gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with IL17RB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evi27 encodes a novel membrane protein with homology to the IL17 receptor. (PubMed id 10815801)1, 2, 3, 9 Tian E....Shaughnessy J.D. Jr. (2000)
    2. A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. (PubMed id 10749887)1, 2, 3 Shi Y.... Ebner R. (2000)
    3. Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2. (PubMed id 22070932)1, 2 Popova A.... Gratchev A. (2012)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    5. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1. (PubMed id 11058597)1, 2 Lee J.... Gurney A.L. (2001)
    9. Association of IL-17RB gene polymorphism with asthma. (PubMed id 19118269)1, 9 Jung J.S....Shin H.D. (2009)
    10. Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance. (PubMed id 18794098)1, 9 Goetz M.P....Ingle J.N. (2008)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55540 HGNC: 18015 AceView: IL17RB Ensembl:ENSG00000056736 euGenes: HUgn55540
    ECgene: IL17RB Kegg: 55540 H-InvDB: IL17RB

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for IL17RB Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/il17rb/

    (Patent information from GeneIP,
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    Patent Information for IL17RB gene:
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