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IL17RB Gene

protein-coding   GIFtS: 60
GCID: GC03P053855

Interleukin 17 Receptor B

(Previous name: interleukin 17B receptor)
(Previous symbol: IL17BR)
  Search for IL17RB
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 17 Receptor B1 2     IL-17 Receptor B2 3
IL17BR1 2 3 5     IL-17 Receptor Homolog 12 3
Interleukin 17B Receptor1 2     IL-17B Receptor2 3
Cytokine Receptor-Like 42 3     IL17RH12 5
Interleukin-17B Receptor2 3     Cytokine Receptor CRL42
CRL42 3     Interleukin 17 Receptor Homolog 12
EVI272 3     Interleukin-17 Receptor B2
IL-17RB2 3     IL17Rh13
IL-17Rh12 3     

External Ids:    HGNC: 180151   Entrez Gene: 555402   Ensembl: ENSG000000567367   OMIM: 6054585   UniProtKB: Q9NRM63   

Export aliases for IL17RB gene to outside databases

Previous GC identifers: GC03P053735 GC03P053837


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL17RB Gene:
The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but
does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the
production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be
significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this
receptor. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL17RB Gene:
IL17RB (interleukin 17 receptor B) is a protein-coding gene. GO annotations related to this gene include cytokine receptor activity. An important paralog of this gene is IL17RA.

UniProtKB/Swiss-Prot: I17RB_HUMAN, Q9NRM6
Function: Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth
and/or differentiation of hematopoietic cells

Gene Wiki entry for IL17RB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL17RB gene promoter:
         S8   POU2F1   Tal-1beta   ITF-2   NF-kappaB   NF-kappaB1   YY1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL17RB promoter sequence
   Search Chromatin IP Primers for IL17RB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL17RB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p21.1

IL17RB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL17RB gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P053855:  view genomic region     (about GC identifiers)

Start:
53,880,577 bp from pter      End:
53,899,827 bp from pter
Size:
19,251 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: I17RB_HUMAN, Q9NRM6 (See protein sequence)
Recommended Name: Interleukin-17 receptor B precursor  
Size: 502 amino acids; 55885 Da
Subunit: Interacts with DAZAP2
Secondary accessions: Q9BPZ0 Q9NRL4 Q9NRM5
Alternative splicing: 2 isoforms:  Q9NRM6-1   Q9NRM6-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for IL17RB: NX_Q9NRM6

Explore proteomics data for IL17RB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn67, Asn103, Asn156, Asn183, Asn197, Asn283
  • Modification sites at PhosphoSitePlus

  • See IL17RB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061195.2  
    ENSEMBL proteins: 
     ENSP00000288167   ENSP00000418638  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 17 receptor B
    IL-17 receptor family

    1 InterPro protein domain:
     IPR013568 SEFIR

    Graphical View of Domain Structure for InterPro Entry Q9NRM6

    ProtoNet protein and cluster: Q9NRM6

    1 Blocks protein domain: IPB013568 SEFIR

    UniProtKB/Swiss-Prot: I17RB_HUMAN, Q9NRM6
    Similarity: Contains 1 SEFIR domain


    Find genes that share domains with IL17RB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I17RB_HUMAN, Q9NRM6
    Function: Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth
    and/or differentiation of hematopoietic cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004896cytokine receptor activity NAS10815801
         
    Find genes that share ontologies with IL17RB           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Il17rb):
     cellular  hematopoietic system  immune system  respiratory system  skeleton 

    Find genes that share phenotypes with IL17RB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IL17RB: Il17rbtm1Anjm Il17rbtm1Bud Il17rbtm1Hwata

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL17RB
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    miRTarBase miRNAs that target IL17RB:
    hsa-mir-155-5p (MIRT020786), hsa-mir-26b-5p (MIRT029443), hsa-mir-192-5p (MIRT026498), hsa-mir-215-5p (MIRT024475)

    Block miRNA regulation of human, mouse, rat IL17RB using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate IL17RB:
    hsa-miR-664
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    Inhib. RNA
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    eBioscience FlowRNA Probe Sets ( VA1-10515) for IL17RB 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    I17RB_HUMAN, Q9NRM6: Isoform 1: Cell membrane; Single-pass type I membrane protein
    I17RB_HUMAN, Q9NRM6: Isoform 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    lysosome1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm IEA--
    GO:0005887integral component of plasma membrane TAS10749887
    GO:0009986cell surface IEA--
    GO:0016020membrane NAS10815801

    Find genes that share ontologies with IL17RB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL17RB About    
    See pathways by source

    SuperPathContained pathways About
    1IL-17 Family Signaling Pathways
    IL-17 Family Signaling Pathways0.51
    IL17 signaling pathway0.51
    2PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43


    Find genes that share SuperPaths with IL17RB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL17RB
        IL-17 Family Signaling Pathways


    1 BioSystems Pathway for IL17RB
        IL17 signaling pathway



    1 Kegg Pathway  (Kegg details for IL17RB):
        Cytokine-cytokine receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL17RB: 
              Th17 Response in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL17RB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for IL17RB (Q9NRM63 ENSP000002881674) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL25Q9H2933, ENSP000003281114I2D: score=3 STRING: ENSP00000328111
    PCNAP120043, ENSP000003684384I2D: score=1 STRING: ENSP00000368438
    IL17BQ9UHF53, ENSP000002617964I2D: score=3 STRING: ENSP00000261796
    SETD8Q9NQR13, ENSP000003329954I2D: score=1 STRING: ENSP00000332995
    IL17RDQ8NFM73I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth NAS10815801
    GO:0006952defense response TAS10749887
    GO:0019221cytokine-mediated signaling pathway NAS10815801

    Find genes that share ontologies with IL17RB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL17RB (I17RB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL17RB gene (2 alternative transcripts): 
    NM_018725.3  NM_172234.1  

    Unigene Cluster for IL17RB:

    Interleukin 17 receptor B
    Hs.654970  [show with all ESTs]
    Unigene Representative Sequence: NM_018725
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000288167(uc003dha.3) ENST00000475124 ENST00000494338
    miRNA
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    hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidIL17RB 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF208110.1 AF212365.1 AF250309.1 AK307749.1 AY359122.1 BC000980.1 

    7 DOTS entries:

    DT.451577  DT.91765740  DT.100787928  DT.95167453  DT.95167455  DT.95167457  DT.307855 

    Selected AceView cDNA sequences (see all 85):

    BQ226353 AW673932 AA007528 AV660618 BX453537 CR615594 NM_018725 NM_172234 
    AI913613 BX483104 AY359122 BM693867 BC000980 AV728939 AF208111 AI401622 
    AI538624 AF212365 AI826949 T96629 AI692717 CF455736 BE047352 AI672344 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for IL17RB    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
    SP1:                                      -     -     -                                       
    SP2:                                                                                          
    SP3:                                                        -                                 
    SP4:                                                  -                                       


    ECgene alternative splicing isoforms for IL17RB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL17RB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAGCAAGA
    IL17RB Expression
    About this image


    IL17RB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Sertoli cells Seminiferous Tubules
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Thymus (Hematopoietic System)
             Thymus
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Brain (Nervous System)
             Cerebral Cortex
    IL17RB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL17RB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654970

    UniProtKB/Swiss-Prot: I17RB_HUMAN, Q9NRM6
    Tissue specificity: Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas,
    testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most
    cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL17RB: 
              Th17 Response in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat IL17RB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17RB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL17RB gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il17rb1 , 5 interleukin 17 receptor B1, 5 79.12(n)1
    74.95(a)1
      14 (18.39 cM)5
    509051  NM_019583.31  NP_062529.21 
     299961415 
    lizard
    (Anolis carolinensis)
    Reptilia IL17RB6
    interleukin 17 receptor B
    39(a)
    1 ↔ 1
    2(160547160-160567783)
    zebrafish
    (Danio rerio)
    Actinopterygii il17ra16
    interleukin 17 receptor A1
    12(a)
    1 ↔ 1
    4(32620151-32622530) ENSDARG00000045617


    ENSEMBL Gene Tree for IL17RB (if available)
    TreeFam Gene Tree for IL17RB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL17RB gene
    IL17RA2  

    Find genes that share paralogs with IL17RB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL17RB (see all 502)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887734001,2
    --53882438(+) CACCTA/GTGGTC 1 -- int10--------
    rs1920837181,2
    --53882504(+) GGTCCA/GTCATA 1 -- int10--------
    rs22323331,2
    C,F--53882661(+) CTTCAA/GCATGA 1 -- int115Minor allele frequency- G:0.22NS NA WA EU 2294
    rs10256901,2
    C,F,O,A,H--53882663(-) CGTCAT/CGTTGA 1 -- int127Minor allele frequency- C:0.22NA EA NS WA CSA EU 3653
    rs58490091,2
    C--53882673(+) CTTGGT/-TTTTT 1 -- int1 trp32Minor allele frequency- -:0.00NA CSA 4
    rs2007845721,2
    C--53882673(-) AAAAAA/CCAAGC 1 -- int10--------
    rs1402549231,2
    C,F--53882694(+) AGACCG/ATTCAA 2 /I /V mis11Minor allele frequency- A:0.00NA 4550
    rs1124859711,2
    C--53882699(+) GTTCAG/ATGTGG 2 /Q syn11Minor allele frequency- A:0.50CSA 2
    rs76506861,2
    C--53882795(+) GGCAAT/CAGGTC 1 -- int14Minor allele frequency- C:0.02NS WA 246
    rs22768391,2
    C,F,H--53882903(+) AGGCCG/CTGTTT 1 -- int125Minor allele frequency- C:0.12EA NS NA WA 3432

    HapMap Linkage Disequilibrium report for IL17RB (53880577 - 53899827 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for IL17RB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876803CNV Loss21882294
    nsv876805CNV Loss21882294
    dgv283n21CNV Loss19592680
    nsv876804CNV Gain21882294

    Human Gene Mutation Database (HGMD): IL17RB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL17RB
    DNA2.0 Custom Variant and Variant Library Synthesis for IL17RB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605458    OMIM disorders: --


    Find genes that share disorders with IL17RB           About GenesLikeMe

    Genetic Association Database (GAD): IL17RB
    Human Genome Epidemiology (HuGE) Navigator: IL17RB (9 documents)

    Export disorders for IL17RB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL17RB gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with IL17RB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evi27 encodes a novel membrane protein with homology to the IL17 receptor. (PubMed id 10815801)1, 2, 3, 9 Tian E....Shaughnessy J.D. Jr. (Oncogene 2000)
    2. A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. (PubMed id 10749887)1, 2, 3 Shi Y.... Ebner R. (J. Biol. Chem. 2000)
    3. Association of IL-17RB gene polymorphism with asthma. (PubMed id 19118269)1, 4, 9 Jung J.S....Shin H.D. (Chest 2009)
    4. Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance. (PubMed id 18794098)1, 4, 9 Goetz M.P....Ingle J.N. (Clin. Cancer Res. 2008)
    5. Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2. (PubMed id 22070932)1, 2 Popova A.... Gratchev A. (Immunobiology 2012)
    6. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    7. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    10. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55540 HGNC: 18015 AceView: IL17RB Ensembl:ENSG00000056736 euGenes: HUgn55540
    ECgene: IL17RB Kegg: 55540 H-InvDB: IL17RB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL17RB Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/il17rb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL17RB gene:
    Search GeneIP for patents involving IL17RB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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