Aliases for IL17RB Gene
External Ids for IL17RB Gene
Previous HGNC Symbols for IL17RB Gene
Previous GeneCards Identifiers for IL17RB Gene
The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL17RB Gene
IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. Diseases associated with IL17RB include chronic mucocutaneous candidiasis. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include cytokine receptor activity and interleukin-17 receptor activity. An important paralog of this gene is IL17RA.
UniProtKB/Swiss-Prot for IL17RB Gene
Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.