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IL17RA Gene

protein-coding   GIFtS: 62
GCID: GC22P017565

Interleukin 17 Receptor A

(Previous name: interleukin 17 receptor)
(Previous symbol: IL17R)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 17 Receptor A1 2     Interleukin 17 Receptor1
IL17R1 2 3 5     CD2172
CDw2172 3     hIL-17R2
IL-17RA2 3     Interleukin-17 Receptor A2
IL-17 Receptor A2 3     CD217 Antigen3
CANDF52 5     

External Ids:    HGNC: 59851   Entrez Gene: 237652   Ensembl: ENSG000001776637   OMIM: 6054615   UniProtKB: Q96F463   

Export aliases for IL17RA gene to outside databases

Previous GC identifers: GC22P015947 GC22P001385


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL17RA Gene:
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer
of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded
by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low
affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and
autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a
multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms.
(provided by RefSeq, Feb 2014)

GeneCards Summary for IL17RA Gene:
IL17RA (interleukin 17 receptor A) is a protein-coding gene. Diseases associated with IL17RA include candidiasis, familial, 5, autosomal recessive, and familial candidiasis 5. GO annotations related to this gene include interleukin-17 receptor activity. An important paralog of this gene is IL17RB.

UniProtKB/Swiss-Prot: I17RA_HUMAN, Q96F46
Function: Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low
affinity, suggesting that additional components are involved in IL17A-induced signaling

Gene Wiki entry for IL17RA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_187355.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL17RA gene promoter:
         GATA-3   AP-1   ATF-2   C/EBPalpha   NF-AT   NF-AT4   NF-AT2   NF-AT3   c-Jun   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL17RA promoter sequence
   Search Chromatin IP Primers for IL17RA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL17RA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.1   Ensembl cytogenetic band:  22q11.1   HGNC cytogenetic band: 22q11.1

IL17RA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL17RA gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P017565:  view genomic region     (about GC identifiers)

Start:
17,565,844 bp from pter      End:
17,596,584 bp from pter
Size:
30,741 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: I17RA_HUMAN, Q96F46 (See protein sequence)
Recommended Name: Interleukin-17 receptor A precursor  
Size: 866 amino acids; 96122 Da
Subunit: Forms heterodimers with IL17RE; the heterodimer binds IL17C
2 PDB 3D structures from and Proteopedia for IL17RA:
3JVF (3D)        4HSA (3D)    
Secondary accessions: O43844 Q20WK1
Alternative splicing: 2 isoforms:  Q96F46-1   Q96F46-2   (Soluble isoform lacking the transmembrane segment)

Explore the universe of human proteins at neXtProt for IL17RA: NX_Q96F46

Explore proteomics data for IL17RA at MOPED

Post-translational modifications: 

  • Glycosylated1
  • Glycosylation2 at Asn49, Asn54, Asn206, Asn225, Asn242, Asn265
  • Modification sites at PhosphoSitePlus

  • See IL17RA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001276834.1  NP_055154.3  

    ENSEMBL proteins: 
     ENSP00000320936  

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    IL17RA Antibody Products:

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    IL17RA Assay Products:

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    Cloud-Clone Corp. CLIAs for IL17RA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 17 receptor A
    IL-17 receptor family

    1 InterPro protein domain:
     IPR013568 SEFIR

    Graphical View of Domain Structure for InterPro Entry Q96F46

    ProtoNet protein and cluster: Q96F46

    1 Blocks protein domain: IPB013568 SEFIR

    UniProtKB/Swiss-Prot: I17RA_HUMAN, Q96F46
    Similarity: Contains 1 SEFIR domain


    IL17RA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I17RA_HUMAN, Q96F46
    Function: Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low
    affinity, suggesting that additional components are involved in IL17A-induced signaling

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0030368interleukin-17 receptor activity NAS9367539
         
    IL17RA for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for IL17RA:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Il17ra):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  integument 
     no phenotypic analysis  respiratory system  tumorigenesis 

    IL17RA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IL17RA: Il17ratm1.2Kurs Il17ratm1Koll

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL17RA
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL17RA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL17RA

    miRNA
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    Block miRNA regulation of human, mouse, rat IL17RA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL17RA (see all 9):
    hsa-miR-582-3p hsa-miR-136 hsa-miR-4311 hsa-miR-4254 hsa-miR-185* hsa-miR-371-5p hsa-miR-29b-1* hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidIL17RA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IL17RA

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17RA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    I17RA_HUMAN, Q96F46: Isoform 1: Membrane; Single-pass type I membrane protein (By similarity)
    I17RA_HUMAN, Q96F46: Isoform 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytosol1
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane ----
    GO:0005887integral component of plasma membrane NAS9367539

    IL17RA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL17RA About    
    See pathways by source

    SuperPathContained pathways About
    1IL-17 Family Signaling Pathways
    IL-17 Family Signaling Pathways0.51
    Mucin expression in CF via IL 6, IL 17 signaling pathways0.48
    IL17 signaling pathway0.51
    2Cytokine production by Th17 cells in CF
    Cytokine production by Th17 cells in CF0.72
    Cytokine production by Th17 cells in CF Mouse model 0.72
    3Th17 Differentiation
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types0.47
    4PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    5NF-kappaB Signaling
    NF-kappaB Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IL17RA
        IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-17 Family Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL17RA (see all 6)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling
    Akt Signaling

    1 Cell Signaling Technology (CST) Pathway for IL17RA
        NF-kappaB Signaling

    3 GeneGo (Thomson Reuters) Pathways for IL17RA
        Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF
    Mucin expression in CF via IL-6, IL-17 signaling pathways

    1 BioSystems Pathway for IL17RA
        IL17 signaling pathway



    1 Kegg Pathway  (Kegg details for IL17RA):
        Cytokine-cytokine receptor interaction


    IL17RA for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL17RA: 
              Th17 Response in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL17RA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for IL17RA (Q96F461, 3 ENSP000003209364) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL17AQ165523, ENSP000003441924I2D: score=2 STRING: ENSP00000344192
    IL17FQ96PD43, ENSP000003374324I2D: score=1 STRING: ENSP00000337432
    IL17REQ8NFR91, ENSP000002959804EBI-5591258,EBI-5591275 STRING: ENSP00000295980
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    IL17RCQ8NAC33, ENSP000002959814I2D: score=1 STRING: ENSP00000295981
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway NAS9367539
    GO:0019221cytokine-mediated signaling pathway NAS9367539
    GO:0032747positive regulation of interleukin-23 production IDA--
    GO:0071345cellular response to cytokine stimulus ----
    GO:0072537fibroblast activation IDA--

    IL17RA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL17RA (I17RA)

    1 Novoseek inferred chemical compound relationship for IL17RA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 50 2 15975820 (1)



    IL17RA for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IL17RA gene (2 alternative transcripts): 
    NM_001289905.1  NM_014339.6  

    Unigene Cluster for IL17RA:

    Interleukin 17 receptor A
    Hs.48353  [show with all ESTs]
    Unigene Representative Sequence: NM_014339
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477874 ENST00000319363(uc002zly.3) ENST00000459971
    miRNA
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    hsa-miR-582-3p hsa-miR-136 hsa-miR-4311 hsa-miR-4254 hsa-miR-185* hsa-miR-371-5p hsa-miR-29b-1* hsa-miR-3692
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    Additional mRNA sequence: 

    AF021799.1 AK056836.1 AK093772.1 BC011624.2 CT841520.1 JF305973.1 U58917.1 

    13 DOTS entries:

    DT.100022476  DT.451919  DT.120666082  DT.91921292  DT.100705530  DT.101975951  DT.75101412  DT.99940778 
    DT.100018208  DT.100779121  DT.120666076  DT.86840469  DT.97770495 

    Selected AceView cDNA sequences (see all 224):

    AI796018 U58917 BU584393 BM992395 AI636250 C01589 AI816903 BU185461 
    BC033291 CA449906 BE018737 BU584056 BF475878 AI825570 AY026052 AW029299 
    BG829431 BC008575 AI285415 CR594472 BX456257 BU584055 AI142122 CN485342 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IL17RA (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                      -                                                         
    SP2:                                      -     -     -                                             
    SP3:              -                       -                                                         
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for IL17RA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL17RA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IL17RA Expression
    About this image


    IL17RA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Hippocampus
    IL17RA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL17RA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.48353

    UniProtKB/Swiss-Prot: I17RA_HUMAN, Q96F46
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL17RA: 
              Th17 Response in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for IL17RA
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    QuantiFast Probe-based Assays in human, mouse, rat IL17RA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17RA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL17RA gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il17ra1 , 5 interleukin 17 receptor A1, 5 76.51(n)1
    69.98(a)1
      6 (56.95 cM)5
    161721  NM_008359.21  NP_032385.11 
     1204631975 
    chicken
    (Gallus gallus)
    Aves IL17RA1 interleukin 17 receptor A 57.65(n)
    48.97(a)
      418158  XM_416389.4  XP_416389.3 
    lizard
    (Anolis carolinensis)
    Reptilia IL17RA6
    interleukin 17 receptor A
    43(a)
    1 ↔ 1
    5(13740724-13765509)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5614941 uncharacterized LOC561494 46.21(n)
    37.52(a)
      561494  NM_001100003.1  NP_001093473.1 


    ENSEMBL Gene Tree for IL17RA (if available)
    TreeFam Gene Tree for IL17RA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for IL17RA gene
    IL17RB2  

    IL17RA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL17RA (see all 924)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1394124251,2
    Cuntested11545471(+) CACCCC/G/TCTCTA 2 P syn10--------
    rs722901191,2
    C--1404649(+) GGAGA-/GTGGTGT 1 -- int10--------
    rs1464161031,2
    C--1404787(+) TGAGA-/GTGGGGA 1 -- int10--------
    rs3679073891,2
    C--1404893(+) GGAGA-/GTGT  
            
    GGTGT
    1 -- int10--------
    rs716435731,2
    C--1404976(+) GAGAG-/GAGT  
            
    GTGTG
    1 -- int10--------
    rs2016113521,2
    --1406580(+) CCGGG-/GTGGGGG 1 -- int10--------
    rs110894121,2
    C--1406581(+) CGGGGG/TGGGGG 1 -- int10--------
    rs1449799831,2
    C--1406581(+) CGGGG-/G/GG/G
    GG
    /GGGG/T
    GGGGG
    2 -- int1 cds10--------
    rs3710936291,2
    C--1406582(+) GGGGT-/GGGGGG 1 -- int10--------
    rs558851381,2
    C--1411376(+) AAAAA-/A/AA  
            
    GATGG
    2 -- ut311NA 2

    HapMap Linkage Disequilibrium report for IL17RA (17565844 - 17596584 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for IL17RA:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv773e201CNV Deletion23290073
    esv2723939CNV Deletion23290073
    esv2723938CNV Deletion23290073
    nsv509805CNV Insertion20534489
    nsv518600CNV Loss19592680
    nsv519563CNV Loss19592680
    nsv521478CNV Loss19592680
    nsv828923CNV Gain20364138

    Human Gene Mutation Database (HGMD): IL17RA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL17RA
    DNA2.0 Custom Variant and Variant Library Synthesis for IL17RA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605461   
    OMIM disorders: 613953  
    UniProtKB/Swiss-Prot: I17RA_HUMAN, Q96F46
  • Candidiasis, familial, 5 (CANDF5) [MIM:613953]: A primary immunodeficiency disorder with altered immune
    responses and impaired clearance of fungal infections, selective against Candida. It is characterized by
    persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus
    Candida, mainly Candida albicans. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • Selected diseases for IL17RA (see all 42):    
    About MalaCards
    candidiasis, familial, 5, autosomal recessive    familial candidiasis 5    stromal keratitis    candidiasis, familial, 2, autosomal recessive
    chronic mucocutaneous candidiasis    keratitis    cat eye syndrome    candidiasis
    rheumatoid arthritis    arthritis    gastric adenocarcinoma    myocarditis
    sjogren's syndrome    bronchiolitis    psoriatic arthritis    gingivitis
    pituitary adenoma    choriocarcinoma    osteoarthritis    graves' disease


    IL17RA for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for IL17RA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 48 1 11966773 (1)
    inflammation 44.1 7 16670527 (3), 12772186 (1), 15972674 (1), 12171537 (1) (see all 6)
    arthritis 38.2 9 11371660 (4), 18495731 (1), 18039580 (1)
    colitis 33.6 3 16670527 (3)
    nasal polyps 32.7 15 16874957 (4), 16805377 (2)
    tumors 0 1 17690908 (1)
    carcinoma 0 1 12772186 (1)

    Genetic Association Database (GAD): IL17RA
    Human Genome Epidemiology (HuGE) Navigator: IL17RA (7 documents)

    Export disorders for IL17RA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL17RA gene, integrated from 10 sources (see all 111):
    (articles sorted by number of sources associating them with IL17RA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of the human interleukin (Il)-17 receptor. (PubMed id 9367539)1, 2, 3 Yao Z.... Armitage R.J. (Cytokine 1997)
    2. Identification of a soluble isoform of human IL-17RA generated by alternative splicing. (PubMed id 24084331)1, 2 Sohda M.... Oda K. (Cytokine 2013)
    3. Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. (PubMed id 21350122)1, 2 Puel A.... Casanova J.L. (Science 2011)
    4. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    5. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    6. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    8. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 3 Dunham I.... Wright H. (Nature 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23765 HGNC: 5985 AceView: IL17R Ensembl:ENSG00000177663 euGenes: HUgn23765
    ECgene: IL17RA Kegg: 23765 H-InvDB: IL17RA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL17RA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL17RA gene:
    Search GeneIP for patents involving IL17RA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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