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Aliases for IL17RA Gene

Aliases for IL17RA Gene

  • Interleukin 17 Receptor A 2 3 5
  • IL-17 Receptor A 3 4
  • IL-17RA 3 4
  • CDw217 3 4
  • IL17R 3 4
  • Interleukin-17 Receptor A 3
  • Interleukin 17 Receptor 2
  • CD217 Antigen 4
  • HIL-17R 3
  • CANDF5 3
  • CD217 3
  • IMD51 3

External Ids for IL17RA Gene

Previous HGNC Symbols for IL17RA Gene

  • IL17R

Previous GeneCards Identifiers for IL17RA Gene

  • GC22P015947
  • GC22P017565
  • GC22P001385

Summaries for IL17RA Gene

Entrez Gene Summary for IL17RA Gene

  • Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

GeneCards Summary for IL17RA Gene

IL17RA (Interleukin 17 Receptor A) is a Protein Coding gene. Diseases associated with IL17RA include Immunodeficiency 51 and Familial Candidiasis 5. Among its related pathways are Akt Signaling and Cytokine production by Th17 cells in CF (Mouse model). GO annotations related to this gene include interleukin-17 receptor activity. An important paralog of this gene is IL17RD.

UniProtKB/Swiss-Prot for IL17RA Gene

  • Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).

Gene Wiki entry for IL17RA Gene

Additional gene information for IL17RA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17RA Gene

Genomics for IL17RA Gene

Regulatory Elements for IL17RA Gene

Enhancers for IL17RA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H017120 0.9 ENCODE 15.7 +36.5 36549 1 ZSCAN4 ZNF76 KLF17 SIN3A GLI4 GLIS2 ZNF366 EGR2 SP3 ZNF280D IL17RA TMEM121B LINC01664
GH22H017084 1.6 FANTOM5 ENCODE dbSUPER 8.1 +1.3 1333 4 HDGF PKNOX1 ATF1 SIN3A DMAP1 TCF12 GLIS2 ZNF143 ATF7 RUNX3 CECR7 ENSG00000273203 IL17RA ADA2 CECR2 RPL31P62
GH22H017106 1 Ensembl ENCODE dbSUPER 12.6 +21.9 21947 1 CTCF POLR2A REST MYC IL17RA TMEM121B GC22P017113 RPL31P62
GH22H017170 1.6 FANTOM5 Ensembl ENCODE 7.5 +87.0 86970 2 HDGF ARNT SIN3A ZNF2 YY1 CBX5 ZNF143 ZNF207 SP3 REST IL17RA HDHD5 RPL32P5
GH22H017121 0.6 ENCODE 16.5 +35.6 35552 0 NRF1 NR2F1 SIN3A MIER2 REST KLF9 ZNF143 EZH2 IL17RA TMEM121B GC22P017113
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL17RA on UCSC Golden Path with GeneCards custom track

Promoters for IL17RA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000143497 546 2201 HDGF PKNOX1 ATF1 SIN3A DMAP1 ZNF143 ATF7 SP3 REST ZNF592

Genomic Location for IL17RA Gene

Chromosome:
22
Start:
17,084,954 bp from pter
End:
17,115,694 bp from pter
Size:
30,741 bases
Orientation:
Plus strand

Genomic View for IL17RA Gene

Genes around IL17RA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17RA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17RA Gene

Proteins for IL17RA Gene

  • Protein details for IL17RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F46-I17RA_HUMAN
    Recommended name:
    Interleukin-17 receptor A
    Protein Accession:
    Q96F46
    Secondary Accessions:
    • O43844
    • Q20WK1

    Protein attributes for IL17RA Gene

    Size:
    866 amino acids
    Molecular mass:
    96122 Da
    Quaternary structure:
    • Forms heterodimers with IL17RE; the heterodimer binds IL17C (PubMed:21993848). Forms heterodimers with IL17RC; the heterodimer binds IL17A and IL17F homodimers as well as the heterodimer formed by IL17A and IL17F (PubMed:16785495, PubMed:18684971).

    Three dimensional structures from OCA and Proteopedia for IL17RA Gene

    Alternative splice isoforms for IL17RA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL17RA Gene

Post-translational modifications for IL17RA Gene

  • Glycosylated.
  • Glycosylation at posLast=4949, isoforms=254, isoforms=267, posLast=206206, isoforms=2225, posLast=242242, and posLast=265265
  • Modification sites at PhosphoSitePlus

Other Protein References for IL17RA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IL17RA (IL-17 RA/IL-17 R)
  • Cell Signaling Technology (CST) Antibodies for IL17RA (IL17RA)

Assay Products

  • Cloud-Clone Corp. Assay Kits for IL17RA

No data available for DME Specific Peptides for IL17RA Gene

Domains & Families for IL17RA Gene

Gene Families for IL17RA Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for IL17RA Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for IL17RA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IL17RA: view

No data available for UniProtKB/Swiss-Prot for IL17RA Gene

Function for IL17RA Gene

Molecular function for IL17RA Gene

UniProtKB/Swiss-Prot Function:
Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).

Phenotypes From GWAS Catalog for IL17RA Gene

Gene Ontology (GO) - Molecular Function for IL17RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005515 protein binding IPI 21993848
GO:0030368 interleukin-17 receptor activity NAS 9367539
genes like me logo Genes that share ontologies with IL17RA: view
genes like me logo Genes that share phenotypes with IL17RA: view

Human Phenotype Ontology for IL17RA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL17RA Gene

MGI Knock Outs for IL17RA:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IL17RA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
  • R&D Systems cDNA Clones for IL17RA (IL-17 RA/IL-17 R)

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL17RA Gene

Localization for IL17RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17RA Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL17RA gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 2
cytosol 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IL17RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS,IBA 9367539
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL17RA: view

Pathways & Interactions for IL17RA Gene

genes like me logo Genes that share pathways with IL17RA: view

SIGNOR curated interactions for IL17RA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL17RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway NAS 9367539
GO:0019221 cytokine-mediated signaling pathway IEA --
GO:0032747 positive regulation of interleukin-23 production IDA 21145111
GO:0050729 positive regulation of inflammatory response IEA --
GO:0050832 defense response to fungus IEA --
genes like me logo Genes that share ontologies with IL17RA: view

Drugs & Compounds for IL17RA Gene

(1) Drugs for IL17RA Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0

(1) Additional Compounds for IL17RA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL17RA: view

Transcripts for IL17RA Gene

Unigene Clusters for IL17RA Gene

Interleukin 17 receptor A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IL17RA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
  • R&D Systems cDNA Clones for IL17RA (IL-17 RA/IL-17 R)

Alternative Splicing Database (ASD) splice patterns (SP) for IL17RA Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6:

Relevant External Links for IL17RA Gene

GeneLoc Exon Structure for
IL17RA
ECgene alternative splicing isoforms for
IL17RA

Expression for IL17RA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL17RA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL17RA Gene

This gene is overexpressed in Whole Blood (x17.9).

Protein differential expression in normal tissues from HIPED for IL17RA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (33.0), Testis (27.4), and Monocytes (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IL17RA Gene



Protein tissue co-expression partners for IL17RA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IL17RA Gene:

IL17RA

SOURCE GeneReport for Unigene cluster for IL17RA Gene:

Hs.48353

mRNA Expression by UniProt/SwissProt for IL17RA Gene:

Q96F46-I17RA_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for IL17RA Gene

  • Blood(4.5)
  • Lung(2.1)
  • Intestine(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IL17RA Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • reproductive
  • respiratory
  • skeleton
Organs:
Head and neck:
  • eye
  • eyelid
  • face
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • pharynx
  • skull
  • tongue
  • tooth
Thorax:
  • esophagus
  • thymus
Abdomen:
  • liver
  • spleen
Pelvis:
  • vagina
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with IL17RA: view

Primer Products

Orthologs for IL17RA Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17RA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL17RA 33 34
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia IL17RA 33 34
  • 79.28 (n)
cow
(Bos Taurus)
Mammalia IL17RA 33 34
  • 77.17 (n)
mouse
(Mus musculus)
Mammalia Il17ra 33 16 34
  • 76.51 (n)
rat
(Rattus norvegicus)
Mammalia Il17ra 33
  • 75.68 (n)
oppossum
(Monodelphis domestica)
Mammalia IL17RA 34
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL17RA 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL17RA 33 34
  • 57.65 (n)
lizard
(Anolis carolinensis)
Reptilia IL17RA 34
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC561494 33
  • 46.21 (n)
BX942819.1 34
  • 35 (a)
OneToMany
IL17RA (1 of 4) 34
  • 31 (a)
OneToMany
il17ra2 34
  • 31 (a)
OneToMany
IL17RA (3 of 4) 34
  • 30 (a)
OneToMany
Species where no ortholog for IL17RA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL17RA Gene

ENSEMBL:
Gene Tree for IL17RA (if available)
TreeFam:
Gene Tree for IL17RA (if available)

Paralogs for IL17RA Gene

Paralogs for IL17RA Gene

genes like me logo Genes that share paralogs with IL17RA: view

Variants for IL17RA Gene

Sequence variations from dbSNP and Humsavar for IL17RA Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1057518744 Pathogenic 17,108,537(+) GAGCA(-/GGAGATGGTGGAGAGCA)ACTCT reference, frameshift-variant
rs1057518745 Pathogenic 17,097,829(+) ACCCT(C/T)GAAAC reference, stop-gained
rs1057518746 Pathogenic 17,097,901(+) GAGAC(-/C)TGTTC reference, frameshift-variant
rs1057518747 Pathogenic 17,103,500(+) CCAGA(-/CCAGA)AGAGT reference, frameshift-variant
rs1057519079 Pathogenic 17,108,378(+) CAGCC(A/G)ACCAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IL17RA Gene

Variant ID Type Subtype PubMed ID
dgv4460n100 CNV gain 25217958
dgv729e201 CNV deletion 23290073
esv2723938 CNV deletion 23290073
esv2723939 CNV deletion 23290073
esv3361550 CNV duplication 20981092
esv3647204 CNV gain 21293372
esv3647208 CNV gain 21293372
nsv1062859 CNV loss 25217958
nsv1064641 CNV gain 25217958
nsv1067241 CNV loss 25217958
nsv509805 CNV insertion 20534489
nsv518600 CNV loss 19592680
nsv519563 CNV loss 19592680
nsv521478 CNV loss 19592680
nsv828923 CNV gain 20364138

Variation tolerance for IL17RA Gene

Residual Variation Intolerance Score: 92.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.97; 92.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL17RA Gene

Human Gene Mutation Database (HGMD)
IL17RA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL17RA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17RA Gene

Disorders for IL17RA Gene

MalaCards: The human disease database

(11) MalaCards diseases for IL17RA Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency 51
  • candf5
familial candidiasis 5
  • familial chronic mucocutaneous candidiasis, autosomal recessive
chronic mucocutaneous candidiasis
  • cmc
adenosine deaminase 2 deficiency
  • ada2 deficiency
nasopharyngitis
  • chronic nasopharyngitis
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

I17RA_HUMAN
  • Immunodeficiency 51 (IMD51) [MIM:613953]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269 PubMed:21350122}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IL17RA

Genetic Association Database (GAD)
IL17RA
Human Genome Epidemiology (HuGE) Navigator
IL17RA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL17RA
genes like me logo Genes that share disorders with IL17RA: view

No data available for Genatlas for IL17RA Gene

Publications for IL17RA Gene

  1. Cutting edge: interleukin 17 signals through a heteromeric receptor complex. (PMID: 16785495) Toy D … Peschon J (Journal of immunology (Baltimore, Md. : 1950) 2006) 3 4 22 60
  2. Molecular characterization of the human interleukin (IL)-17 receptor. (PMID: 9367539) Yao Z … Armitage RJ (Cytokine 1997) 2 3 4 60
  3. Identification of a soluble isoform of human IL-17RA generated by alternative splicing. (PMID: 24084331) Sohda M … Oda K (Cytokine 2013) 3 4 60
  4. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. (PMID: 21993848) Ramirez-Carrozzi V … Pappu R (Nature immunology 2011) 3 4 60
  5. Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. (PMID: 21350122) Puel A … Casanova JL (Science (New York, N.Y.) 2011) 3 4 60

Products for IL17RA Gene

Sources for IL17RA Gene

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