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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL17RA Gene

protein-coding   GIFtS: 57
GCID: GC22P017565

interleukin 17 receptor A

(Previous name: interleukin 17 receptor )
(Previous symbol: IL17R)
 Explore 32 diseases affiliated with
IL17RA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IL17RA    

Aliases
for IL17RA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Interleukin 17 Receptor A1 2     IL-17 Receptor A2 3
IL17R1 2 3 5     Interleukin 17 Receptor1
CDw2171 2 3     CANDF52
IL-17RA1 2 3     Interleukin-17 Receptor A2
CD2171 2     CD217 Antigen3
HIL-17R1     

External Ids:    HGNC: 59851   Entrez Gene: 237652   Ensembl: ENSG000001776637   OMIM: 6054615   UniProtKB: Q96F463   

Export aliases for IL17RA gene to outside databases

Previous GC identifers: GC22P015947 GC22P001385


Summaries
for IL17RA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IL17RA:
Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the
maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin
17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A.
Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as
rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: I17RA_HUMAN, Q96F46
Function: Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity,
suggesting that additional components are involved in IL17A-induced signaling

Gene Wiki entry for IL17RA


Genomic Views
for IL17RA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011519.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL17RA gene promoter:
         GATA-3   AP-1   ATF-2   C/EBPalpha   NF-AT   NF-AT4   NF-AT2   NF-AT3   c-Jun   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL17RA promoter sequence
   Search SABiosciences Chromatin IP Primers for IL17RA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL17RA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.1   Ensembl cytogenetic band:  22q11.1   HGNC cytogenetic band: 22q11.1

IL17RA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL17RA gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P017565:  view genomic region     (about GC identifiers)

Start:
 17,565,844 bp from pter      End:
 17,596,583 bp from pter
Size:
 30,740 bases      Orientation:
 plus strand

Proteins
for IL17RA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: I17RA_HUMAN, Q96F46 (See protein sequence)
Recommended Name: Interleukin-17 receptor A precursor  
Size: 866 amino acids; 96122 Da
Subunit: Forms heterodimers with IL17RE; the heterodimer binds IL17C
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)
1 PDB 3D structure from and Proteopedia for IL17RA:
3JVF (3D)    
Secondary accessions: O43844 Q20WK1

Explore the universe of human proteins at neXtProt for IL17RA: NX_Q96F46

Post-translational modifications:

  • Glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96F46

    • IL17RA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055154.3  
    ENSEMBL proteins: 
     ENSP00000400078   ENSP00000320936  

    Human Recombinant Protein Products: 
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    Novus Biologicals IL17RA Proteins
    Novus Biologicals IL17RA Lysate
    Sino Biological Recombinant Protein for IL17RA
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IL17RA

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane NAS9367539


    IL17RA for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for IL17RA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IL17RA for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR013568 SEFIR

    Graphical View of Domain Structure for InterPro Entry Q96F46

    ProtoNet protein and cluster: Q96F46

    1 Blocks protein family: IPB013568 SEFIR

    UniProtKB/Swiss-Prot: I17RA_HUMAN, Q96F46
    Similarity: Contains 1 SEFIR domain


    Function
    for IL17RA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: I17RA_HUMAN, Q96F46
    Function: Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity,
    suggesting that additional components are involved in IL17A-induced signaling

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: IL17RA 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0030368interleukin-17 receptor activity NAS9367539


    IL17RA for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for IL17RA:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

    Animal Models:
         Mouse knock-out Il17ratm1Koll for IL17RA
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Il17ra):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  respiratory system 
     tumorigenesis 

    IL17RA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IL17RA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mucin expression in CF via IL-6, IL-17 signaling pathways
    		Mucin expression in CF via IL-6, IL-17 signaling pathways1.00
    		Cytokine production by Th17 cells in CF (Mouse model)0.37
    		Cytokine production by Th17 cells in CF0.45
    2NF-kappaB Signaling
    		NF-kappaB Signaling1.00
    3Th17 Differentiation
    		IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types0.47
    4PEDF Induced Signaling
    		Cytokine-cytokine receptor interaction0.26

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for IL17RA
        IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types


    1 Cell Signaling Technology (CST) Pathway for IL17RA
        NF-kappaB Signaling

    3 GeneGo (Thomson Reuters) Pathways for IL17RA
        Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF
    Mucin expression in CF via IL-6, IL-17 signaling pathways


    1         Kegg Pathway  (Kegg details for IL17RA):
        Cytokine-cytokine receptor interaction


    IL17RA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL17RA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/14 Interacting proteins for IL17RA (Q96F461, 3 ENSP000003209364) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL17AQ165523, ENSP000003441924I2D: score=2 STRING: ENSP00000344192
    IL17FQ96PD43, ENSP000003374324I2D: score=1 STRING: ENSP00000337432
    IL17REQ8NFR91, ENSP000002959804EBI-5591258,EBI-5591275 STRING: ENSP00000295980
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    TRAF3IP2O437343, ENSP000003459844I2D: score=2 STRING: ENSP00000345984
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway NAS9367539
    GO:0032747positive regulation of interleukin-23 production IDA--
    GO:0072537fibroblast activation IDA--
    GO:1900017positive regulation of cytokine production involved in inflammatory response IEA--


    IL17RA for ontologies           About GeneDecksing



    Drugs & Compounds
    for IL17RA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL17RA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL17RA
    1 Novoseek chemical compound relationship for IL17RA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 50 2 15975820 (1)

    Search CenterWatch for drugs/clinical trials and news about IL17RA / I17RA 

    Transcripts
    for IL17RA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IL17RA gene: 
    NM_014339.6  

    Unigene Cluster for IL17RA:

    Interleukin 17 receptor A
    Hs.48353  [show with all ESTs]
    Unigene Representative Sequence: NM_014339
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477874 ENST00000425985 ENST00000319363(uc002zly.3) ENST00000459971


    miRNA
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    hsa-miR-582-3p hsa-miR-136 hsa-miR-4311 hsa-miR-4254 hsa-miR-185* hsa-miR-371-5p hsa-miR-29b-1* hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmid: IL17RA 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL17RA (see all 7)
    OriGene shRNA RFP: IL17RA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL17RA
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF021799.1 AK056836.1 AK093772.1 BC011624.2 CT841520.1 JF305973.1 U58917.1 

    13 DOTS entries:

    DT.100022476  DT.451919  DT.120666082  DT.91921292  DT.100705530  DT.101975951  DT.75101412  DT.99940778 
    DT.100018208  DT.100779121  DT.120666076  DT.86840469  DT.97770495 

    24/224 AceView cDNA sequences (see all 224):

    BM992395 BU185461 CN485342 BU584055 CR594472 AI796018 AY026052 C01589 
    BU584056 BC008575 BU584393 AI816903 BF475878 AI636250 U58917 CA449906 
    AI285415 BC033291 AI142122 AW029299 BG829431 BE018737 BX456257 AI825570 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for IL17RA (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                      -                                                         
    SP2:                                      -     -     -                                             
    SP3:              -                       -                                                         
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for IL17RA

    Expression
    for IL17RA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL17RA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IL17RA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See IL17RA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL17RA

    SOURCE GeneReport for Unigene cluster: Hs.48353

    UniProtKB/Swiss-Prot: I17RA_HUMAN, Q96F46
    Tissue specificity: Widely expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL17RA: 
              Th17 Response in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for IL17RA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IL17RA gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IL17RA1 interleukin 17 receptor A 57.35(n)
    48.77(a)    		   418158  XM_416389.3  XP_416389.2 
    lizard
    (Anolis carolinensis)    		 Reptilia IL17RA6
    		 --
    		 45(a)
    		 1 ↔ 1
    		 5(13750698-13763334)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1000059241 interleukin-17 receptor A-like 47.04(n)
    39.42(a)    		   100005924  XM_001921169.2  XP_001921204.2 


    ENSEMBL Gene Tree for IL17RA (if available)
    TreeFam Gene Tree for IL17RA (if available) 

    Paralogs
    for IL17RA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL17RA gene
    IL17RB2  

    IL17RA for paralogs           About GeneDecksing



    Genomic Variants
    for IL17RA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/733 NCBI SNPs in IL17RA are shown (see all 733)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs413809481,2
    		C,F,--1384195(+) AGTCAG/AGATCT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs413294441,2
    		C,--1384303(+) CCGCGA/CGGAGG 1 -- us2k10--------
    rs414330451,2
    		C,--1384415(+) TCTATT/CTAGAC 1 -- us2k12Minor allele frequency- C:0.05WA 120
    rs414612451,2
    		C,--1384635(+) AATACA/TGGGAA 1 -- us2k10--------
    rs414960521,2
    		C,--1384636(+) ATACAG/TGGAAA 1 -- us2k12Minor allele frequency- T:0.25CSA WA 120
    rs413615471,2
    		C,F,--1384785(+) GGACGG/CGCTCG 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs414558461,2
    		C,F,--1385204(+) CTCAGG/AAGGCA 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs414766501,2
    		C,F,--1385265(+) GGTTGC/TACCAC 1 -- us2k11Minor allele frequency- T:0.23WA 118
    rs413578471,2
    		C,--1385267(+) TTGCAC/GCACTG 1 -- us2k10--------
    rs581061321,2
    		--1385492(+) GGCCAA/GGGTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL17RA (17565844 - 17596583 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for IL17RA
         1 CNV: 50797
    Human Gene Mutation Database (HGMD): IL17RA

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    Disorders / Diseases
    for IL17RA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IL17RA for disorders           About GeneDecksing

    OMIM gene information: 605461    OMIM disorders: --

    UniProtKB/Swiss-Prot: I17RA_HUMAN, Q96F46
  • Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5) [MIM:613953]. CANDF5 is a rare
    • disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is
    characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of
    the genus Candida, mainly Candida albicans

    20/32 diseases for IL17RA (see all 32):    About MalaCards
    rheumatoid arthritis    arthritis    chronic mucocutaneous candidiasis    cat eye syndrome
    candidiasis    pituitary adenoma    bronchiolitis    cystic fibrosis
    squamous cell carcinoma    sjogren's syndrome    keratitis    myocarditis
    gastric adenocarcinoma    hepatitis b    liver disease    choriocarcinoma
    adenoma    fibrosis    gingivitis    osteoarthritis

    7 Novoseek disease relationships for IL17RA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 48 1 11966773 (1)
    inflammation 44.1 7 16670527 (3), 12772186 (1), 15972674 (1), 12171537 (1) (see all 6)
    arthritis 38.2 9 11371660 (4), 18495731 (1), 18039580 (1)
    colitis 33.6 3 16670527 (3)
    nasal polyps 32.7 15 16874957 (4), 16805377 (2)
    tumors 0 1 17690908 (1)
    carcinoma 0 1 12772186 (1)

    Human Genome Epidemiology (HuGE) Navigator: IL17RA (7 documents)

    Export disorders for IL17RA gene to outside databases

    Publications
    for IL17RA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL17RA gene, integrated from 9 sources (see all 99):
    (articles sorted by number of sources associating them with IL17RA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of the human interleukin (Il)-17 receptor. (PubMed id 9367539)1, 2, 3 Yao Z.... Armitage R.J. (1997)
    2. Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. (PubMed id 21350122)1, 2 Puel A.... Casanova J.L. (2011)
    3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 3 Dunham I....O'Brien K.P. (1999)
    7. High in vivo expression of interleukin-17 receptor in synovial endothelial cells and chondrocytes from arthritis patients. (PubMed id 11371660)1, 9 Honorati M.C....Facchini A. (2001)
    8. Interleukin-17F signaling requires ubiquitination of interleukin-17 receptor via TRAF6. (PubMed id 17346928)1, 9 Rong Z....Chang Z. (2007)
    9. Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis. (PubMed id 11966773)1, 9 Kehlen A....Langner J. (2002)
    10. IL-17RA and IL-17RC receptors are essential for IL-17A-induced ELR+ CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid blood. (PubMed id 18097068)1, 9 Zrioual S....Miossec P. (2008)

    External Searches for IL17RA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing IL17RA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23765 HGNC: 5985 AceView: IL17R Ensembl:ENSG00000177663 euGenes: HUgn23765
    ECgene: IL17RA Kegg: 23765 H-InvDB: IL17RA

    Other Databases showing IL17RA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IL17RA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL17RA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IL17RA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IL17RA gene:
    Search GeneIP for patents involving IL17RA

    GeneCards and IP:
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