Aliases for IL17RA Gene
External Ids for IL17RA Gene
Previous HGNC Symbols for IL17RA Gene
Previous GeneCards Identifiers for IL17RA Gene
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]
GeneCards Summary for IL17RA Gene
IL17RA (Interleukin 17 Receptor A) is a Protein Coding gene. Diseases associated with IL17RA include candidiasis, familial, 5, autosomal recessive and chronic mucocutaneous candidosis. Among its related pathways are Akt Signaling and PAK Pathway. GO annotations related to this gene include interleukin-17 receptor activity. An important paralog of this gene is IL17RB.
UniProtKB/Swiss-Prot for IL17RA Gene
Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.