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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL17F Gene

protein-coding   GIFtS: 56
GCID: GC06M052101

interleukin 17F

 Explore 47 diseases affiliated with
IL17F via our new
 Human Malady Compendium 
Biological research products
for IL17F
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Interleukin 17F1 2     CANDF62
IL-17F1 2 3     Interleukin-17F1
ML11 2 5     Interleukin-243
ML-11 2     Mutant IL-17F2
Cytokine ML-12 3     IL243
IL-242 3     Interleukin-243

External Ids:    HGNC: 164041   Entrez Gene: 1127442   Ensembl: ENSG000001121167   OMIM: 6064965   UniProtKB: Q96PD43   

Export aliases for IL17F gene to outside databases

Previous GC identifers: GC06M052103 GC06M052148 GC06M052209 GC06M051932


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL17F:
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by
activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and
CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells
to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IL17F_HUMAN, Q96PD4
Function: Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor,
and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL17F gene promoter:
         GATA-3   AP-1   ATF-2   GATA-1   GATA-2   CREB   deltaCREB   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL17F promoter sequence
   Search SABiosciences Chromatin IP Primers for IL17F

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL17F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12   Ensembl cytogenetic band:  6p12.2   HGNC cytogenetic band: 6p12

IL17F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL17F gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M052101:  view genomic region     (about GC identifiers)

Start:
52,101,479 bp from pter      End:
52,109,335 bp from pter
Size:
7,857 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL17F_HUMAN, Q96PD4 (See protein sequence)
Recommended Name: Interleukin-17F precursor  
Size: 163 amino acids; 18045 Da
Subunit: Homodimer; disulfide-linked
Subcellular location: Secreted
Sequence caution: Sequence=AAL14427.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=CAD92646.1;
Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for IL17F:
1JPY (3D)        3JVF (3D)    
Secondary accessions: Q6NSI0 Q7Z6P4 Q96PI8 Q9NUE6

Explore the universe of human proteins at neXtProt for IL17F: NX_Q96PD4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96PD4

  • IL17F Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_443104.1  
    ENSEMBL proteins: 
     ENSP00000337432  

    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IL17F

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS11574464
    GO:0005615extracellular space IEA--


    IL17F for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    IL17F for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR020440 Interleukin-17_chordata
     IPR010345 Interleukin-17

    Graphical View of Domain Structure for InterPro Entry Q96PD4

    ProtoNet protein and cluster: Q96PD4

    1 Blocks protein family: IPB010345 Interleukin-17

    UniProtKB/Swiss-Prot: IL17F_HUMAN, Q96PD4
    Similarity: Belongs to the IL-17 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: IL17F_HUMAN, Q96PD4
    Function: Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor,
    and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis

    miRNA
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    miRTarBase miRNAs that target IL17F:
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate IL17F:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL17F 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL17F (see all 7)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17F

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IDA11591732
    GO:0005126cytokine receptor binding IEA--
    GO:0019955cytokine binding IDA11574464
    GO:0042803protein homodimerization activity IDA11574464


    IL17F for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for IL17F: Il17ftm2Yiw Il17a/Il17fIl17a/tm1.1Impr Il17ftm1Awai Il17ftm1Yiw
         9 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Il17f):
     cellular  craniofacial  digestive/alimentary  hematopoietic system  immune system 
     mortality/aging  normal  respiratory system  skeleton 

    IL17F for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mucin expression in CF via IL-6, IL-17 signaling pathways
    Mucin expression in CF via IL-6, IL-17 signaling pathways1.00
    Cytokine production by Th17 cells in CF (Mouse model)0.37
    Cytokine production by Th17 cells in CF0.45
    2Development_PDGF signaling via STATs and NF-kB
    Immune response_IL-23 signaling pathway0.44
    IL23-mediated signaling events0.15
    Immune response IL-23 signaling pathway0.41
    3Th17 Differentiation
    Th17 Differentiation1.00
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types0.47

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for IL17F
        Immune response IL-23 signaling pathway

    2 R&D Systems Pathways for IL17F
        IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th17 Differentiation


    4 GeneGo (Thomson Reuters) Pathways for IL17F
        Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF
    Mucin expression in CF via IL-6, IL-17 signaling pathways
    Immune response IL-23 signaling pathway

    1 BioSystems Pathway for IL17F 
        IL23-mediated signaling events



    IL17F for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL17F

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for IL17F (Q96PD43 ENSP000003374324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL17RAQ96F463, ENSP000003209364I2D: score=1 STRING: ENSP00000320936
    STAT3P407633, ENSP000002646574I2D: score=1 STRING: ENSP00000264657
    IL17RCQ8NAC33, ENSP000002959814I2D: score=1 STRING: ENSP00000295981
    IL17AQ165523I2D: score=1 
    STAT5AP422293I2D: score=1 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006029proteoglycan metabolic process IDA11574464
    GO:0006954inflammatory response IEA--
    GO:0016525negative regulation of angiogenesis IDA11591732
    GO:0017015regulation of transforming growth factor beta receptor signaling pathway IDA11591732
    GO:0042089cytokine biosynthetic process IDA11591732


    IL17F for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL17F
    Search CenterWatch for drugs/clinical trials and news about IL17F 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL17F gene: 
    NM_052872.3  

    Unigene Cluster for IL17F:

    Interleukin 17F
    Hs.272295  [show with all ESTs]
    Unigene Representative Sequence: AF332389
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478427(uc003pal.1) ENST00000336123(uc003pam.1)

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate IL17F:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL17F 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF332389.1 AF384857.1 BC070124.1 JF305974.1 

    2 DOTS entries:

    DT.97802452  DT.97784418 

    6 AceView cDNA sequences:

    NM_172343 AF384857 NM_052872 CD639406 AF332389 BC070124 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL17F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCAGTAAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See IL17F Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL17F

    SOURCE GeneReport for Unigene cluster: Hs.272295

    UniProtKB/Swiss-Prot: IL17F_HUMAN, Q96PD4
    Tissue specificity: Expressed in activated, but not resting, CD4+ T-cells and activated monocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL17F (see all 6): 
              Th17 Response in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17F

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL17F gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves IL17F1 interleukin 17F 62.07(n)
    50.86(a)
      428665  XM_426223.3  XP_426223.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    36(a)
    1 → many
    1(122877784-122879470)
    zebrafish
    (Danio rerio)
    Actinopterygii il17a/f26
    interleukin 17a/f2
    27(a)
    1 → many
    17(12593558-12596932)


    ENSEMBL Gene Tree for IL17F (if available)
    TreeFam Gene Tree for IL17F (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL17F gene
    IL17A2  IL17D2  IL17B2  IL17C2  
    2 SIMAP similar genes for IL17F using alignment to 1 protein entry:     IL17F_HUMAN:
    IL17A    IL17C

    IL17F for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/153 NCBI SNPs in IL17F are shown (see all 153    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114655571,2
    C,--51932333(-) ATGGTG/AGCCAC 1 -- ds50014Minor allele frequency- A:0.02NA EU WA 208
    rs6417011,2
    C,F,O,A,H,--51932392(-) CATATG/CGAAGG 1 -- ds500125Minor allele frequency- C:0.14NS EA NA EU WA CSA 2374
    rs114655561,2
    C,F,H,--51932438(-) TGGCCA/TCTGTG 1 -- ds50018Minor allele frequency- T:0.02NA EU NS EA WA 628
    rs114655551,2
    C,F,H,--51932661(-) AGACTG/ATGTAG 1 -- ds500111Minor allele frequency- A:0.02NA EU NS EA WA 1294
    rs19533251,2
    C,F,--51932713(-) AATAAT/GTTAAA 1 -- ut315Minor allele frequency- G:0.04NA EU 216
    rs114655541,2
    C,F,H,--51932820(-) AACAGA/GAAATA 1 -- ut3111Minor allele frequency- G:0.03NA EU NS EA WA 1302
    rs168693561,2
    C,F,H,--51933598(+) TAGTCG/AGTCTA 1 -- int18Minor allele frequency- A:0.02NA NS EA WA 678
    rs69013701,2
    H--51933660(+) TCAGAC/TCTTCT 1 -- int1 trp34Minor allele frequency- T:0.00NS EA 420
    rs6122421,2
    C,F,O,A,H,--51934387(-) ATTCAG/CTCAGA 1 -- int196Minor allele frequency- C:0.23NS NA EU EA PA CA WA CSA 4878
    rs114655511,2
    C,F,H,--51935091(-) GGTGCA/GAAGAG 1 -- int19Minor allele frequency- G:0.03NA EU NS EA 636

    HapMap Linkage Disequilibrium report for IL17F (52101479 - 52109335 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IL17F: --
    Human Gene Mutation Database (HGMD): IL17F

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL17F
    DNA2.0 Custom Variant and Variant Library Synthesis for IL17F

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IL17F for disorders           About GeneDecksing

    OMIM gene information: 606496    OMIM disorders: --

    UniProtKB/Swiss-Prot: IL17F_HUMAN, Q96PD4
  • Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6) [MIM:613956]. CANDF6 is a rare disorder
  • with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is
    characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of
    the genus Candida, mainly Candida albicans

    20/47 diseases for IL17F (see all 47):    About MalaCards
    graft versus host disease    chronic mucocutaneous candidiasis    allergic contact dermatitis    contact dermatitis
    autoimmune polyendocrine syndrome    chronic obstructive pulmonary disease    cutaneous lupus erythematosus    chronic fatigue syndrome
    lupus erythematosus    inflammatory bowel disease    atopic dermatitis    candidiasis
    dermatitis    ulcerative colitis    dyspepsia    myocardial infarction
    spondyloarthropathy    cystic fibrosis    behcet's disease    pulmonary disease

    10 Novoseek disease relationships for IL17F gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 50.8 2 19034630 (1)
    autoimmunity 48.4 1 18280574 (1), 19144313 (1)
    inflammation 46.8 10 18992745 (2), 20375986 (1), 15972674 (1), 16630936 (1) (see all 10)
    necrosis 29.5 6 14601514 (1), 18061474 (1), 15657292 (1), 20519880 (1) (see all 6)
    asthma 18.7 20 15703761 (5), 16630936 (4), 16961709 (1), 19361847 (1) (see all 5)
    bronchoalveolar lavage fluid 15.7 1 15703761 (1)
    tumors 15.7 20 20210523 (3), 17352237 (2), 17292626 (2), 14601514 (1) (see all 10)
    pneumonia 0 1 15477493 (1)
    cancer 0 3 14601514 (1), 7779151 (1), 17644350 (1), 19904747 (1)
    hyperplasia 0 1 15477493 (1)

    Genetic Association Database (GAD): IL17F
    Human Genome Epidemiology (HuGE) Navigator: IL17F (24 documents)

    Export disorders for IL17F gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL17F gene, integrated from 9 sources (see all 130):
    (articles sorted by number of sources associating them with IL17F)
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    1. Identification of a novel cytokine, ML-1, and its expression in subjects with asthma. (PubMed id 11591768)1, 2, 3, 9 Kawaguchi M.... Huang S.-K. (2001)
    2. IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. (PubMed id 11591732)1, 2, 3, 9 Starnes T.... Hromas R. (2001)
    3. Polymorphisms in the interleukin 17F gene (IL17F) and asthma. (PubMed id 15703761)1, 4, 9 Ramsey C.D....Celedon J.C. (2005)
    4. IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. (PubMed id 11574464)1, 2, 9 Hymowitz S.G.... Starovasnik M.A. (2001)
    5. Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. (PubMed id 21350122)1, 2 Puel A.... Casanova J.L. (2011)
    6. Structural basis of receptor sharing by interleukin 1 7 cytokines. (PubMed id 19838198)1, 2 Ely L.K....Garcia K.C. (2009)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    9. IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity. (PubMed id 16630936)1, 9 Kawaguchi M....Adachi M. (2006)
    10. Interleukin-17F suppresses hepatocarcinoma cell growt h via inhibition of tumor angiogenesis. (PubMed id 20210523)1, 9 Xie Y....Yang J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 112744 HGNC: 16404 AceView: IL17F Ensembl:ENSG00000112116 euGenes: HUgn112744
    ECgene: IL17F H-InvDB: IL17F

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL17F Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL17F Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_17

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL17F gene:
    Search GeneIP for patents involving IL17F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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