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Aliases for IL17F Gene

Aliases for IL17F Gene

  • Interleukin 17F 2 3 5
  • Cytokine ML-1 3 4
  • IL-17F 3 4
  • Interleukin-17F 3
  • CANDF6 3
  • ML-1 3
  • ML1 3

External Ids for IL17F Gene

Previous GeneCards Identifiers for IL17F Gene

  • GC06M052103
  • GC06M052148
  • GC06M051932
  • GC06M052101

Summaries for IL17F Gene

Entrez Gene Summary for IL17F Gene

  • The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL17F Gene

IL17F (Interleukin 17F) is a Protein Coding gene. Diseases associated with IL17F include Candidiasis, Familial, 6 and Chronic Mucocutaneous Candidiasis. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and cytokine receptor binding. An important paralog of this gene is IL17A.

UniProtKB/Swiss-Prot for IL17F Gene

  • Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity).

Additional gene information for IL17F Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17F Gene

Genomics for IL17F Gene

GeneHancer (GH) Regulatory Elements for IL17F Gene

Promoters and enhancers for IL17F Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I052244 Promoter 0.5 EPDnew 550.8 +1.2 1173 0.1 IL17F SLC25A20P1 LOC105375088
GH06I052388 Enhancer 2.1 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10.2 -144.5 -144502 3.7 HDGF FOXA2 SMAD1 MLX ARID4B FEZF1 IRF4 YY1 ZNF766 JUNB EFHC1 PAQR8 MCM3 IL17F SLC25A20P1 PIR61259
GH06I052396 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -153.5 -153535 4.8 ELF3 FOXA2 ARID4B BMI1 BATF ZNF2 RAD21 RARA SLC30A9 ARID2 MCM3 EFHC1 PAQR8 IL17F SLC25A20P1 PIR61259
GH06I052154 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +89.4 89390 4.1 PKNOX1 BATF IRF4 ETS1 SCRT2 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 GC06P052155 IL17F SLC25A20P1 IL17A PKHD1 MCM3 PAQR8 GC06M052169
GH06I052535 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.6 -296.7 -296714 13.3 PKNOX1 FOXA2 SMAD1 MLX ARID4B IRF4 YY1 SLC30A9 SP5 JUNB EFHC1 TRAM2-AS1 TRAM2 MCM3 IL17F SLC25A20P1 PAQR8 LOC730101 GC06P052544 PIR31355
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IL17F on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL17F gene promoter:

Genomic Locations for IL17F Gene

Genomic Locations for IL17F Gene
chr6:52,236,681-52,245,689
(GRCh38/hg38)
Size:
9,009 bases
Orientation:
Minus strand
chr6:52,101,479-52,109,335
(GRCh37/hg19)

Genomic View for IL17F Gene

Genes around IL17F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17F Gene

Proteins for IL17F Gene

  • Protein details for IL17F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PD4-IL17F_HUMAN
    Recommended name:
    Interleukin-17F
    Protein Accession:
    Q96PD4
    Secondary Accessions:
    • Q6NSI0
    • Q7Z6P4
    • Q96PI8
    • Q9NUE6

    Protein attributes for IL17F Gene

    Size:
    163 amino acids
    Molecular mass:
    18045 Da
    Quaternary structure:
    • Homodimer; disulfide-linked (PubMed:19838198). Heterodimer with IL17A (PubMed:17355969).
    SequenceCaution:
    • Sequence=AAL14427.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAD92646.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL17F Gene

neXtProt entry for IL17F Gene

Post-translational modifications for IL17F Gene

Other Protein References for IL17F Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL17F Gene

Domains & Families for IL17F Gene

Gene Families for IL17F Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted secreted proteins

Protein Domains for IL17F Gene

Suggested Antigen Peptide Sequences for IL17F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PD4

UniProtKB/Swiss-Prot:

IL17F_HUMAN :
  • Belongs to the IL-17 family.
Family:
  • Belongs to the IL-17 family.
genes like me logo Genes that share domains with IL17F: view

Function for IL17F Gene

Molecular function for IL17F Gene

UniProtKB/Swiss-Prot Function:
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity).

Phenotypes From GWAS Catalog for IL17F Gene

Gene Ontology (GO) - Molecular Function for IL17F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IDA 11591732
GO:0005126 cytokine receptor binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0019955 cytokine binding IDA 11574464
GO:0042803 protein homodimerization activity IDA 11574464
genes like me logo Genes that share ontologies with IL17F: view
genes like me logo Genes that share phenotypes with IL17F: view

Human Phenotype Ontology for IL17F Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL17F Gene

MGI Knock Outs for IL17F:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for IL17F Gene

Localization for IL17F Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17F Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL17F gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IL17F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IL17F: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL17F Gene

Pathways & Interactions for IL17F Gene

genes like me logo Genes that share pathways with IL17F: view

Gene Ontology (GO) - Biological Process for IL17F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0010469 regulation of receptor activity IEA --
GO:0016525 negative regulation of angiogenesis IDA 11591732
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway IDA 11591732
GO:0042089 cytokine biosynthetic process IDA 11591732
genes like me logo Genes that share ontologies with IL17F: view

No data available for SIGNOR curated interactions for IL17F Gene

Drugs & Compounds for IL17F Gene

(1) Drugs for IL17F Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Y-320 Pharma 0

(1) ApexBio Compounds for IL17F Gene

Compound Action Cas Number
Y-320 288250-47-5
genes like me logo Genes that share compounds with IL17F: view

Drug Products

Transcripts for IL17F Gene

mRNA/cDNA for IL17F Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL17F Gene

Interleukin 17F:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL17F Gene

No ASD Table

Relevant External Links for IL17F Gene

GeneLoc Exon Structure for
IL17F
ECgene alternative splicing isoforms for
IL17F

Expression for IL17F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL17F Gene

mRNA differential expression in normal tissues according to GTEx for IL17F Gene

This gene is overexpressed in Testis (x17.9), Esophagus - Mucosa (x7.6), and Small Intestine - Terminal Ileum (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of IL17F Gene:

IL17F

SOURCE GeneReport for Unigene cluster for IL17F Gene:

Hs.272295

mRNA Expression by UniProt/SwissProt for IL17F Gene:

Q96PD4-IL17F_HUMAN
Tissue specificity: Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.

Evidence on tissue expression from TISSUES for IL17F Gene

  • Blood(4.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IL17F Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • reproductive
  • respiratory
  • skeleton
Organs:
Head and neck:
  • eye
  • eyelid
  • face
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • pharynx
  • skull
  • tongue
  • tooth
Thorax:
  • esophagus
  • thymus
Abdomen:
  • liver
  • spleen
Pelvis:
  • vagina
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with IL17F: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for IL17F Gene

Orthologs for IL17F Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL17F 33 34
  • 98.98 (n)
dog
(Canis familiaris)
Mammalia IL17F 33 34
  • 74.51 (n)
rat
(Rattus norvegicus)
Mammalia Il17f 33
  • 73.68 (n)
mouse
(Mus musculus)
Mammalia Il17f 33 16 34
  • 72.92 (n)
cow
(Bos Taurus)
Mammalia IL17F 33 34
  • 72.19 (n)
oppossum
(Monodelphis domestica)
Mammalia IL17F 34
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL17F 34
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL17F 33
  • 54.97 (n)
-- 34
  • 39 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 28 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734106 33
  • 53.19 (n)
zebrafish
(Danio rerio)
Actinopterygii il17a/f3 34
  • 27 (a)
ManyToMany
il17a/f1 34
  • 24 (a)
ManyToMany
Species where no ortholog for IL17F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL17F Gene

ENSEMBL:
Gene Tree for IL17F (if available)
TreeFam:
Gene Tree for IL17F (if available)

Paralogs for IL17F Gene

Paralogs for IL17F Gene

(2) SIMAP similar genes for IL17F Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IL17F: view

Variants for IL17F Gene

Sequence variations from dbSNP and Humsavar for IL17F Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs11465553 likely-benign, benign, Familial Candidiasis, Dominant, Candidiasis, familial, 6 52,236,960(-) C/T coding_sequence_variant, missense_variant
rs11465554 likely-benign, Familial Candidiasis, Dominant 52,236,795(-) T/C 3_prime_UTR_variant
rs117796773 likely-benign, uncertain-significance, Familial Candidiasis, Dominant, Candidiasis, familial, 6 52,238,729(-) C/A/T splice_donor_variant
rs140679432 likely-benign, Familial Candidiasis, Dominant 52,244,477(-) A/G 5_prime_UTR_variant
rs144576902 likely-benign, Familial Candidiasis, Dominant 52,236,954(-) G/A/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for IL17F Gene

Variant ID Type Subtype PubMed ID
nsv830662 CNV gain 17160897

Variation tolerance for IL17F Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.73; 66.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL17F Gene

Human Gene Mutation Database (HGMD)
IL17F
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL17F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17F Gene

Disorders for IL17F Gene

MalaCards: The human disease database

(10) MalaCards diseases for IL17F Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search IL17F in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IL17F_HUMAN
  • Candidiasis, familial, 6 (CANDF6) [MIM:613956]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269 PubMed:21350122}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for IL17F

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL17F: view

No data available for Genatlas for IL17F Gene

Publications for IL17F Gene

  1. Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. (PMID: 11591732) Starnes T … Hromas R (Journal of immunology (Baltimore, Md. : 1950) 2001) 2 3 4 22 58
  2. Identification of a novel cytokine, ML-1, and its expression in subjects with asthma. (PMID: 11591768) Kawaguchi M … Huang SK (Journal of immunology (Baltimore, Md. : 1950) 2001) 2 3 4 22 58
  3. Association between polymorphisms in interleukin-17A and interleukin-17F genes and risks of gastric cancer. (PMID: 19904747) Wu X … Hu P (International journal of cancer 2010) 3 22 44 58
  4. Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis. (PMID: 19414056) Shibata T … Arisawa T (Human immunology 2009) 3 22 44 58
  5. The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis. (PMID: 17828618) Arisawa T … Nakano H (Journal of clinical immunology 2008) 3 22 44 58

Products for IL17F Gene

Sources for IL17F Gene

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