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IL17F Gene

protein-coding   GIFtS: 58
GCID: GC06M052101

Interleukin 17F

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 17F1 2     ML12 5
Cytokine ML-12 3     ML-12
IL-17F2 3     interleukin-17F2
CANDF62 5     

External Ids:    HGNC: 164041   Entrez Gene: 1127442   Ensembl: ENSG000001121167   OMIM: 6064965   UniProtKB: Q96PD43   

Export aliases for IL17F gene to outside databases

Previous GC identifers: GC06M052103 GC06M052148 GC06M052209 GC06M051932


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL17F Gene:
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is
expressed by activated T cells, and has been shown to stimulate the production of several other cytokines,
including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells
and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. (provided by
RefSeq, Jul 2008)

GeneCards Summary for IL17F Gene:
IL17F (interleukin 17F) is a protein-coding gene. Diseases associated with IL17F include candidiasis, familial, 6, autosomal dominant, and familial candidiasis 6. GO annotations related to this gene include cytokine binding and protein homodimerization activity. An important paralog of this gene is IL17A.

UniProtKB/Swiss-Prot: IL17F_HUMAN, Q96PD4
Function: Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating
factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits
angiogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL17F gene promoter:
         GATA-3   AP-1   ATF-2   GATA-1   GATA-2   CREB   deltaCREB   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL17F promoter sequence
   Search Chromatin IP Primers for IL17F

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL17F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12   Ensembl cytogenetic band:  6p12.2   HGNC cytogenetic band: 6p12

IL17F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL17F gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M052101:  view genomic region     (about GC identifiers)

Start:
52,101,479 bp from pter      End:
52,109,335 bp from pter
Size:
7,857 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IL17F_HUMAN, Q96PD4 (See protein sequence)
Recommended Name: Interleukin-17F precursor  
Size: 163 amino acids; 18045 Da
Subunit: Homodimer; disulfide-linked
Sequence caution: Sequence=AAL14427.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=CAD92646.1;
Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for IL17F:
1JPY (3D)        3JVF (3D)    
Secondary accessions: Q6NSI0 Q7Z6P4 Q96PI8 Q9NUE6

Explore the universe of human proteins at neXtProt for IL17F: NX_Q96PD4

Explore proteomics data for IL17F at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn83

  • See IL17F Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443104.1  
    ENSEMBL proteins: 
     ENSP00000337432  

    IL17F Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IL17F
    OriGene Protein Over-expression Lysate for IL17F
    OriGene Custom MassSpec
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    GenScript Purified and Recombinant Proteins for IL17F
    Novus Biologicals IL17F Proteins
    Novus Biologicals IL17F Lysates
    Sino Biological Recombinant Protein for IL17F
    Sino Biological Cell Lysate for IL17F
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    Cloud-Clone Corp. Proteins for IL17F

    IL17F Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL17F
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    Novus Biologicals IL17F Antibodies
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    IL17F Assay Products:

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    GenScript Custom Assay Services for IL17F
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL17F
    Cloud-Clone Corp. CLIAs for IL17F


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    2 InterPro protein domains:
     IPR010345 IL-17_fam
     IPR020440 IL-17_chr

    Graphical View of Domain Structure for InterPro Entry Q96PD4

    ProtoNet protein and cluster: Q96PD4

    1 Blocks protein domain: IPB010345 Interleukin-17

    UniProtKB/Swiss-Prot: IL17F_HUMAN, Q96PD4
    Similarity: Belongs to the IL-17 family


    IL17F for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL17F_HUMAN, Q96PD4
    Function: Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating
    factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits
    angiogenesis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IDA11591732
    GO:0005126cytokine receptor binding IEA--
    GO:0019955cytokine binding IDA11574464
    GO:0042803protein homodimerization activity IDA11574464
         
    IL17F for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Il17f):
     craniofacial  digestive/alimentary  hematopoietic system  immune system  mortality/aging 
     normal  respiratory system  skeleton 

    IL17F for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IL17F: Il17ftm2Yiw Il17a/Il17fIl17a/tm1.1Impr Il17ftm1Awai Il17ftm1Yiw

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL17F
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL17F

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL17F
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL17F

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat IL17F using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate IL17F:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL17F 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL17F
    Predesigned siRNA for gene silencing in human, mouse, rat IL17F

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for IL17F (see all 5)
    OriGene ORF clones in mouse, rat for IL17F
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL17F (NM_052872)
    Sino Biological Human cDNA Clone for IL17F
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL17F
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL17F

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IL17F 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17F


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL17F_HUMAN, Q96PD4: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS11574464
    GO:0005615extracellular space IEA--

    IL17F for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL17F About    
    See pathways by source

    SuperPathContained pathways About
    1IL-17 Family Signaling Pathways
    IL-17 Family Signaling Pathways0.51
    Mucin expression in CF via IL 6, IL 17 signaling pathways0.48
    IL17 signaling pathway0.51
    2Immune response IL 23 signaling pathway
    Immune response IL 23 signaling pathway0.41
    IL23-mediated signaling events0.38
    3Cytokine production by Th17 cells in CF
    Cytokine production by Th17 cells in CF0.72
    Cytokine production by Th17 cells in CF Mouse model 0.72
    4Th17 Differentiation
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types0.47
    Th17 Differentiation0.47
    5Leishmaniasis
    Inflammatory bowel disease (IBD)0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for IL17F
        IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    IL-17 Family Signaling Pathways
    Th17 Differentiation


    4 GeneGo (Thomson Reuters) Pathways for IL17F
        Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF
    Mucin expression in CF via IL-6, IL-17 signaling pathways
    Immune response IL-23 signaling pathway

    2 BioSystems Pathways for IL17F
        IL17 signaling pathway
    IL23-mediated signaling events



    1 Kegg Pathway  (Kegg details for IL17F):
        Inflammatory bowel disease (IBD)


    IL17F for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL17F (see all 6): 
              Th17 Response in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL17F

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for IL17F (Q96PD43 ENSP000003374324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL17RAQ96F463, ENSP000003209364I2D: score=1 STRING: ENSP00000320936
    STAT3P407633, ENSP000002646574I2D: score=1 STRING: ENSP00000264657
    IL17RCQ8NAC33, ENSP000002959814I2D: score=1 STRING: ENSP00000295981
    IL17AQ165523I2D: score=1 
    STAT5AP422293I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006029proteoglycan metabolic process IDA11574464
    GO:0006954inflammatory response IEA--
    GO:0016525negative regulation of angiogenesis IDA11591732
    GO:0017015regulation of transforming growth factor beta receptor signaling pathway IDA11591732
    GO:0042089cytokine biosynthetic process IDA11591732

    IL17F for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL17F



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IL17F gene: 
    NM_052872.3  

    Unigene Cluster for IL17F:

    Interleukin 17F
    Hs.272295  [show with all ESTs]
    Unigene Representative Sequence: AF332389
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478427(uc003pal.1) ENST00000336123(uc003pam.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat IL17F using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate IL17F:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidIL17F 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: IL17F (NM_052872)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL17F
      QuantiTect SYBR Green Assays in human, mouse, rat IL17F
      QuantiFast Probe-based Assays in human, mouse, rat IL17F

    Additional mRNA sequence: 

    AF332389.1 AF384857.1 BC070124.1 JF305974.1 

    2 DOTS entries:

    DT.97802452  DT.97784418 

    6 AceView cDNA sequences:

    NM_172343 AF384857 NM_052872 BC070124 CD639406 AF332389 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL17F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAGTAAGA
    IL17F Expression
    About this image

    IL17F Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL17F Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.272295

    UniProtKB/Swiss-Prot: IL17F_HUMAN, Q96PD4
    Tissue specificity: Expressed in activated, but not resting, CD4+ T-cells and activated monocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL17F (see all 6): 
              Th17 Response in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17F

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL17F gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il17f1 , 5 interleukin 17F1, 5 72.92(n)1
    56.25(a)1
      1 (6.49 cM)5
    2576301  NM_145856.21  NP_665855.21 
     207771515 
    chicken
    (Gallus gallus)
    Aves IL17F1 interleukin 17F 54.97(n)
    43.05(a)
      395111  NM_204460.1  NP_989791.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    28(a)
    1 → many
    1(122877292-122881562)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017341061 interleukin-17A-like 53.19(n)
    48.94(a)
      101734106  XM_004914980.1  XP_004915037.1 
    zebrafish
    (Danio rerio)
    Actinopterygii il17a/f36
    il17a/f16
    interleukin 17a/f1
    27(a)
    24(a)
    many ↔ many
    many ↔ many
    20(34816774-34819073) ENSDARG00000041976
    17(12573842-12576188) ENSDARG00000043933


    ENSEMBL Gene Tree for IL17F (if available)
    TreeFam Gene Tree for IL17F (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL17F gene
    IL17A2  IL17C2  
    2 SIMAP similar genes for IL17F using alignment to 1 protein entry:     IL17F_HUMAN:
    IL17A    IL17C

    IL17F for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL17F (see all 239)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0658134
    Candidiasis, familial, 6 (CANDF6)4--see VAR_0658132 S L mis40--------
    rs775005101,2
    --51940632(+) AGGGGG/TTTTTT 1 -- us2k10--------
    rs114655591,2
    C,F,H--52013622(-) GGGCAC/TGCAAG 1 -- ds500111Minor allele frequency- T:0.07NA EU NS EA WA CSA 754
    rs114655571,2
    C--52013707(-) ATGGTG/AGCCAC 1 -- ds50014Minor allele frequency- A:0.02NA EU WA 208
    rs1408234121,2
    --52013708(+) TGGCCA/TCCATG 1 -- ds50010--------
    rs6417011,2
    C,F,O,A,H--52013766(-) CATATG/CGAAGG 1 -- ds500125Minor allele frequency- C:0.14NS EA NA EU WA CSA 2374
    rs114655561,2
    C,F,H--52013812(-) TGGCCA/TCTGTG 1 -- ds50018Minor allele frequency- T:0.02NA EU NS EA WA 628
    rs1873163901,2
    --52013856(+) GATAAG/TGAAGC 1 -- ds50010--------
    rs114655551,2
    C,F,H--52014035(-) AGACTG/ATGTAG 1 -- ds500111Minor allele frequency- A:0.02NA EU NS EA WA 1294
    rs1929723241,2
    --52014041(+) AGTCTC/GTGAGT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for IL17F (52101479 - 52109335 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL17F:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830662CNV Gain17160897

    Human Gene Mutation Database (HGMD): IL17F
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL17F
    DNA2.0 Custom Variant and Variant Library Synthesis for IL17F

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606496   
    OMIM disorders: 613956  
    UniProtKB/Swiss-Prot: IL17F_HUMAN, Q96PD4
  • Candidiasis, familial, 6 (CANDF6) [MIM:613956]: A primary immunodeficiency disorder with altered immune
    responses and impaired clearance of fungal infections, selective against Candida. It is characterized by
    persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus
    Candida, mainly Candida albicans. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • Selected diseases for IL17F (see all 61):    
    About MalaCards
    candidiasis, familial, 6, autosomal dominant    familial candidiasis 6    chronic mucocutaneous candidiasis    candidiasis, familial, 2, autosomal recessive
    neuromyelitis optica    allergic contact dermatitis    candidiasis    h. pylori infection
    contact dermatitis    spondyloarthropathy    dyspepsia    autoimmune polyendocrine syndrome
    cutaneous lupus erythematosus    chronic fatigue syndrome    acute graft versus host disease    gastric adenocarcinoma
    graft versus host disease    dermatitis    crohn's disease    periodontal disease


    IL17F for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for IL17F gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 50.8 2 19034630 (1)
    autoimmunity 48.4 1 18280574 (1), 19144313 (1)
    inflammation 46.8 10 18992745 (2), 20375986 (1), 15972674 (1), 16630936 (1) (see all 10)
    necrosis 29.5 6 14601514 (1), 18061474 (1), 15657292 (1), 20519880 (1) (see all 6)
    asthma 18.7 20 15703761 (5), 16630936 (4), 16961709 (1), 19361847 (1) (see all 5)
    bronchoalveolar lavage fluid 15.7 1 15703761 (1)
    tumors 15.7 20 20210523 (3), 17352237 (2), 17292626 (2), 14601514 (1) (see all 10)
    pneumonia 0 1 15477493 (1)
    cancer 0 3 14601514 (1), 7779151 (1), 17644350 (1), 19904747 (1)
    hyperplasia 0 1 15477493 (1)

    Genetic Association Database (GAD): IL17F
    Human Genome Epidemiology (HuGE) Navigator: IL17F (24 documents)

    Export disorders for IL17F gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL17F gene, integrated from 10 sources (see all 148):
    (articles sorted by number of sources associating them with IL17F)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel cytokine, ML-1, and its expression in subjects with asthma. (PubMed id 11591768)1, 2, 3, 9 Kawaguchi M.... Huang S.-K. (J. Immunol. 2001)
    2. IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. (PubMed id 11591732)1, 2, 3, 9 Starnes T.... Hromas R. (J. Immunol. 2001)
    3. IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity. (PubMed id 16630936)1, 4, 9 Kawaguchi M....Adachi M. (J. Allergy Clin. Immunol. 2006)
    4. Polymorphisms in the interleukin 17F gene (IL17F) and asthma. (PubMed id 15703761)1, 4, 9 Ramsey C.D....CeledA^n J.C. (Genes Immun. 2005)
    5. IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. (PubMed id 11574464)1, 2, 9 Hymowitz S.G.... Starovasnik M.A. (EMBO J. 2001)
    6. The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis. (PubMed id 17828618)1, 4, 9 Arisawa T....Nakano H. (J. Clin. Immunol. 2008)
    7. Interleukin-17F gene polymorphisms in Korean patients with BehAset's disease. (PubMed id 18769923)1, 4, 9 Jang W.C....Kim S.K. (Rheumatol. Int. 2008)
    8. Role of interleukin-17F in chronic inflammatory and allergic lung disease. (PubMed id 16961709)1, 4, 9 Hizawa N....Nishimura M. (Clin. Exp. Allergy 2006)
    9. Association between polymorphisms in interleukin-17A and interleukin-17F genes and risks of gastric cancer. (PubMed id 19904747)1, 4, 9 Wu X....Hu P. (Int. J. Cancer 2010)
    10. Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis. (PubMed id 19414056)1, 4, 9 Shibata T....Arisawa T. (Hum. Immunol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 112744 HGNC: 16404 AceView: IL17F Ensembl:ENSG00000112116 euGenes: HUgn112744
    ECgene: IL17F Kegg: 112744 H-InvDB: IL17F

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL17F Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL17F Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_17

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL17F gene:
    Search GeneIP for patents involving IL17F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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