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Aliases for IL17F Gene

Aliases for IL17F Gene

  • Interleukin 17F 2 3
  • Cytokine ML-1 3 4
  • CANDF6 3 6
  • IL-17F 3 4
  • ML1 3 6
  • Interleukin-17F 3
  • ML-1 3

External Ids for IL17F Gene

Summaries for IL17F Gene

Entrez Gene Summary for IL17F Gene

  • The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL17F Gene

IL17F (Interleukin 17F) is a Protein Coding gene. Diseases associated with IL17F include candidiasis, familial, 6, autosomal dominant and chronic mucocutaneous candidiasis. Among its related pathways are IL-17 Family Signaling Pathways and IL-17 Family Signaling Pathways. GO annotations related to this gene include protein homodimerization activity and cytokine binding. An important paralog of this gene is IL17A.

UniProtKB/Swiss-Prot for IL17F Gene

  • Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17F Gene

Genomics for IL17F Gene

Genomic Location for IL17F Gene

Start:
52,236,681 bp from pter
End:
52,244,537 bp from pter
Size:
7,857 bases
Orientation:
Minus strand

Genomic View for IL17F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL17F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17F Gene

Regulatory Elements for IL17F Gene

Proteins for IL17F Gene

  • Protein details for IL17F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PD4-IL17F_HUMAN
    Recommended name:
    Interleukin-17F
    Protein Accession:
    Q96PD4
    Secondary Accessions:
    • Q6NSI0
    • Q7Z6P4
    • Q96PI8
    • Q9NUE6

    Protein attributes for IL17F Gene

    Size:
    163 amino acids
    Molecular mass:
    18045 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.
    SequenceCaution:
    • Sequence=AAL14427.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAD92646.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL17F Gene

neXtProt entry for IL17F Gene

Proteomics data for IL17F Gene at MOPED

Post-translational modifications for IL17F Gene

Other Protein References for IL17F Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL17F Gene

Domains for IL17F Gene

Gene Families for IL17F Gene

HGNC:
  • IL :Interleukins and interleukin receptors

Protein Domains for IL17F Gene

Suggested Antigen Peptide Sequences for IL17F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PD4

UniProtKB/Swiss-Prot:

IL17F_HUMAN
Family:
  • Belongs to the IL-17 family.:
    • Q96PD4
genes like me logo Genes that share domains with IL17F: view

Function for IL17F Gene

Molecular function for IL17F Gene

UniProtKB/Swiss-Prot Function: Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis

Gene Ontology (GO) - Molecular Function for IL17F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IDA 11591732
GO:0005126 cytokine receptor binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0019955 cytokine binding IDA 11574464
GO:0042803 protein homodimerization activity IDA 11574464
genes like me logo Genes that share ontologies with IL17F: view
genes like me logo Genes that share phenotypes with IL17F: view

Animal Models for IL17F Gene

MGI Knock Outs for IL17F:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IL17F Gene

Localization for IL17F Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17F Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL17F Gene COMPARTMENTS Subcellular localization image for IL17F gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IL17F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 11574464
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IL17F: view

Pathways for IL17F Gene

genes like me logo Genes that share pathways with IL17F: view

Gene Ontology (GO) - Biological Process for IL17F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006029 proteoglycan metabolic process IDA 11574464
GO:0006954 inflammatory response IEA --
GO:0016525 negative regulation of angiogenesis IDA 11591732
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway IDA 11591732
GO:0042089 cytokine biosynthetic process IDA 11591732
genes like me logo Genes that share ontologies with IL17F: view

Transcripts for IL17F Gene

mRNA/cDNA for IL17F Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL17F Gene

Interleukin 17F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL17F Gene

No ASD Table

Relevant External Links for IL17F Gene

GeneLoc Exon Structure for
IL17F
ECgene alternative splicing isoforms for
IL17F

Expression for IL17F Gene

mRNA expression in normal human tissues for IL17F Gene

mRNA differential expression in normal tissues according to GTEx for IL17F Gene

This gene is overexpressed in Testis (17.9), Esophagus - Mucosa (7.6), and Small Intestine - Terminal Ileum (4.2).

SOURCE GeneReport for Unigene cluster for IL17F Gene Hs.272295

mRNA Expression by UniProt/SwissProt for IL17F Gene

Q96PD4-IL17F_HUMAN
Tissue specificity: Expressed in activated, but not resting, CD4+ T-cells and activated monocytes
genes like me logo Genes that share expressions with IL17F: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for IL17F Gene

Orthologs for IL17F Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL17F 35
  • 98.98 (n)
  • 98.16 (a)
IL17F 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL17F 35
  • 72.19 (n)
  • 56.05 (a)
IL17F 36
  • 52 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL17F 35
  • 74.51 (n)
  • 60.13 (a)
IL17F 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il17f 35
  • 72.92 (n)
  • 56.25 (a)
Il17f 16
Il17f 36
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL17F 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL17F 36
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il17f 35
  • 73.68 (n)
  • 59.87 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 39 (a)
ManyToMany
IL17F 35
  • 54.97 (n)
  • 43.05 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734106 35
  • 53.19 (n)
  • 48.94 (a)
zebrafish
(Danio rerio)
Actinopterygii il17a/f1 36
  • 24 (a)
ManyToMany
il17a/f3 36
  • 27 (a)
ManyToMany
Species with no ortholog for IL17F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL17F Gene

ENSEMBL:
Gene Tree for IL17F (if available)
TreeFam:
Gene Tree for IL17F (if available)

Paralogs for IL17F Gene

Paralogs for IL17F Gene

Selected SIMAP similar genes for IL17F Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IL17F: view

Variants for IL17F Gene

Sequence variations from dbSNP and Humsavar for IL17F Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs597506 -- 52,244,823(-) TGACA(A/G)GGGTG upstream-variant-2KB
rs612242 -- 52,238,362(-) ATTCA(C/G)TCAGA intron-variant
rs641701 -- 52,236,367(-) CATAT(C/G)GAAGG downstream-variant-500B
rs677901 -- 52,246,303(-) GGTAA(C/T)GGGCA upstream-variant-2KB
rs721430 -- 52,237,842(-) TTCTC(A/G)GTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL17F Gene

Variant ID Type Subtype PubMed ID
nsv830662 CNV Gain 17160897

Relevant External Links for IL17F Gene

HapMap Linkage Disequilibrium report
IL17F
Human Gene Mutation Database (HGMD)
IL17F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17F Gene

Disorders for IL17F Gene

(1) OMIM Diseases for IL17F Gene (606496)

UniProtKB/Swiss-Prot

IL17F_HUMAN
  • Candidiasis, familial, 6 (CANDF6) [MIM:613956]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269 PubMed:21350122}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(10) Novoseek inferred disease relationships for IL17F Gene

Disease -log(P) Hits PubMed IDs
autoimmune diseases 50.8 1
autoimmunity 48.4 2
inflammation 46.8 11
necrosis 29.5 6
asthma 18.7 12

Relevant External Links for IL17F

Genetic Association Database (GAD)
IL17F
Human Genome Epidemiology (HuGE) Navigator
IL17F
genes like me logo Genes that share disorders with IL17F: view

Publications for IL17F Gene

  1. IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. (PMID: 11591732) Starnes T. … Hromas R. (J. Immunol. 2001) 2 3 4 23
  2. Identification of a novel cytokine, ML-1, and its expression in subjects with asthma. (PMID: 11591768) Kawaguchi M. … Huang S.-K. (J. Immunol. 2001) 2 3 4 23
  3. Polymorphisms in the interleukin 17F gene (IL17F) and asthma. (PMID: 15703761) Ramsey C.D. … CeledA^n J.C. (Genes Immun. 2005) 3 23 48
  4. IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity. (PMID: 16630936) Kawaguchi M. … Adachi M. (J. Allergy Clin. Immunol. 2006) 3 23 48
  5. Role of interleukin-17F in chronic inflammatory and allergic lung disease. (PMID: 16961709) Hizawa N. … Nishimura M. (Clin. Exp. Allergy 2006) 3 23 48

Products for IL17F Gene

Sources for IL17F Gene

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