Aliases for IL17F Gene
External Ids for IL17F Gene
Previous GeneCards Identifiers for IL17F Gene
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL17F Gene
IL17F (Interleukin 17F) is a Protein Coding gene. Diseases associated with IL17F include Candidiasis, Familial, 6, Autosomal Dominant and Chronic Mucocutaneous Candidiasis. Among its related pathways are Cytokine production by Th17 cells in CF (Mouse model) and Th17 Differentiation Pathway. GO annotations related to this gene include protein homodimerization activity and cytokine receptor binding. An important paralog of this gene is IL17A.
UniProtKB/Swiss-Prot for IL17F Gene
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity).