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Aliases for IL17F Gene

Aliases for IL17F Gene

  • Interleukin 17F 2 3 5
  • Cytokine ML-1 3 4
  • IL-17F 3 4
  • CANDF6 3
  • ML-1 3
  • ML1 3

External Ids for IL17F Gene

Previous GeneCards Identifiers for IL17F Gene

  • GC06M052103
  • GC06M052148
  • GC06M051932
  • GC06M052101

Summaries for IL17F Gene

Entrez Gene Summary for IL17F Gene

  • The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL17F Gene

IL17F (Interleukin 17F) is a Protein Coding gene. Diseases associated with IL17F include candidiasis, familial, 6, autosomal dominant and chronic mucocutaneous candidiasis. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein homodimerization activity and cytokine receptor binding. An important paralog of this gene is IL17A.

UniProtKB/Swiss-Prot for IL17F Gene

  • Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17F Gene

Genomics for IL17F Gene

Regulatory Elements for IL17F Gene

Genomic Location for IL17F Gene

Chromosome:
6
Start:
52,236,681 bp from pter
End:
52,245,689 bp from pter
Size:
9,009 bases
Orientation:
Minus strand

Genomic View for IL17F Gene

Genes around IL17F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17F Gene

Proteins for IL17F Gene

  • Protein details for IL17F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PD4-IL17F_HUMAN
    Recommended name:
    Interleukin-17F
    Protein Accession:
    Q96PD4
    Secondary Accessions:
    • Q6NSI0
    • Q7Z6P4
    • Q96PI8
    • Q9NUE6

    Protein attributes for IL17F Gene

    Size:
    163 amino acids
    Molecular mass:
    18045 Da
    Quaternary structure:
    • Homodimer; disulfide-linked (PubMed:19838198). Heterodimer with IL17A (PubMed:17355969).
    SequenceCaution:
    • Sequence=AAL14427.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAD92646.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL17F Gene

neXtProt entry for IL17F Gene

Proteomics data for IL17F Gene at MOPED

Post-translational modifications for IL17F Gene

  • Glycosylation at Asn 83
  • Modification sites at PhosphoSitePlus

Other Protein References for IL17F Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for IL17F

No data available for DME Specific Peptides for IL17F Gene

Domains & Families for IL17F Gene

Gene Families for IL17F Gene

Protein Domains for IL17F Gene

Suggested Antigen Peptide Sequences for IL17F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PD4

UniProtKB/Swiss-Prot:

IL17F_HUMAN :
  • Belongs to the IL-17 family.
Family:
  • Belongs to the IL-17 family.
genes like me logo Genes that share domains with IL17F: view

Function for IL17F Gene

Molecular function for IL17F Gene

UniProtKB/Swiss-Prot Function:
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity).

Gene Ontology (GO) - Molecular Function for IL17F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with IL17F: view
genes like me logo Genes that share phenotypes with IL17F: view

Human Phenotype Ontology for IL17F Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL17F Gene

MGI Knock Outs for IL17F:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL17F

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for IL17F Gene

Localization for IL17F Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17F Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL17F Gene COMPARTMENTS Subcellular localization image for IL17F gene
Compartment Confidence
extracellular 5
nucleus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for IL17F Gene

Pathways & Interactions for IL17F Gene

genes like me logo Genes that share pathways with IL17F: view

Gene Ontology (GO) - Biological Process for IL17F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0042089 cytokine biosynthetic process IDA 11591732
GO:0042109 lymphotoxin A biosynthetic process IDA 11591732
GO:0045408 regulation of interleukin-6 biosynthetic process IDA 11574464
GO:0045414 regulation of interleukin-8 biosynthetic process IDA 11574464
genes like me logo Genes that share ontologies with IL17F: view

No data available for SIGNOR curated interactions for IL17F Gene

Drugs & Compounds for IL17F Gene

No Compound Related Data Available

Transcripts for IL17F Gene

mRNA/cDNA for IL17F Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL17F Gene

Interleukin 17F:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL17F Gene

No ASD Table

Relevant External Links for IL17F Gene

GeneLoc Exon Structure for
IL17F
ECgene alternative splicing isoforms for
IL17F

Expression for IL17F Gene

mRNA expression in normal human tissues for IL17F Gene

mRNA differential expression in normal tissues according to GTEx for IL17F Gene

This gene is overexpressed in Testis (x17.9), Esophagus - Mucosa (x7.6), and Small Intestine - Terminal Ileum (x4.2).

SOURCE GeneReport for Unigene cluster for IL17F Gene Hs.272295

mRNA Expression by UniProt/SwissProt for IL17F Gene

Q96PD4-IL17F_HUMAN
Tissue specificity: Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.
genes like me logo Genes that share expression patterns with IL17F: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for IL17F Gene

Orthologs for IL17F Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17F Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL17F 35
  • 72.19 (n)
  • 56.05 (a)
IL17F 36
  • 52 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL17F 35
  • 74.51 (n)
  • 60.13 (a)
IL17F 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il17f 35
  • 72.92 (n)
  • 56.25 (a)
Il17f 16
Il17f 36
  • 56 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL17F 35
  • 98.98 (n)
  • 98.16 (a)
IL17F 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il17f 35
  • 73.68 (n)
  • 59.87 (a)
oppossum
(Monodelphis domestica)
Mammalia IL17F 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL17F 36
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL17F 35
  • 54.97 (n)
  • 43.05 (a)
-- 36
  • 39 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734106 35
  • 53.19 (n)
  • 48.94 (a)
zebrafish
(Danio rerio)
Actinopterygii il17a/f1 36
  • 24 (a)
ManyToMany
il17a/f3 36
  • 27 (a)
ManyToMany
Species with no ortholog for IL17F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL17F Gene

ENSEMBL:
Gene Tree for IL17F (if available)
TreeFam:
Gene Tree for IL17F (if available)

Paralogs for IL17F Gene

Paralogs for IL17F Gene

(2) SIMAP similar genes for IL17F Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IL17F: view

Variants for IL17F Gene

Sequence variations from dbSNP and Humsavar for IL17F Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_058287 -
VAR_058288 -
VAR_058289 -
VAR_065813 Candidiasis, familial, 6 (CANDF6)
rs597506 -- 52,244,823(-) TGACA(A/G)GGGTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IL17F Gene

Variant ID Type Subtype PubMed ID
nsv830662 CNV Gain 17160897

Variation tolerance for IL17F Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.73; 66.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL17F Gene

HapMap Linkage Disequilibrium report
IL17F
Human Gene Mutation Database (HGMD)
IL17F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17F Gene

Disorders for IL17F Gene

MalaCards: The human disease database

(7) MalaCards diseases for IL17F Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
candidiasis, familial, 6, autosomal dominant
  • candidiasis, familial, 7
chronic mucocutaneous candidiasis
  • cmc
candidiasis
  • disseminated candidiasis
mouth disease
  • mouth diseases
acute generalized exanthematous pustulosis
  • agep
- elite association - COSMIC cancer census association via MalaCards
Search IL17F in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IL17F_HUMAN
  • Candidiasis, familial, 6 (CANDF6) [MIM:613956]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269 PubMed:21350122}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IL17F

Genetic Association Database (GAD)
IL17F
Human Genome Epidemiology (HuGE) Navigator
IL17F
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL17F
genes like me logo Genes that share disorders with IL17F: view

No data available for Genatlas for IL17F Gene

Publications for IL17F Gene

  1. Identification of a novel cytokine, ML-1, and its expression in subjects with asthma. (PMID: 11591768) Kawaguchi M. … Huang S.-K. (J. Immunol. 2001) 2 3 4 23 67
  2. IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. (PMID: 11591732) Starnes T. … Hromas R. (J. Immunol. 2001) 2 3 23
  3. Association between polymorphisms in interleukin-17A and interleukin-17F genes and risks of gastric cancer. (PMID: 19904747) Wu X. … Hu P. (Int. J. Cancer 2010) 3 23
  4. Interleukin-17F suppresses hepatocarcinoma cell growth via inhibition of tumor angiogenesis. (PMID: 20210523) Xie Y. … Yang J. (Cancer Invest. 2010) 3 23
  5. IL-17 in cutaneous lupus erythematosus. (PMID: 20493423) Tanasescu C. … Georgescu A. (Eur. J. Intern. Med. 2010) 3 23

Products for IL17F Gene

Sources for IL17F Gene

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