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Aliases for IL17D Gene

Aliases for IL17D Gene

  • Interleukin 17D 2 3 5
  • Interleukin 27 2 3
  • IL-17D 3 4
  • IL-27 3 4
  • IL27 3 4
  • Interleukin-27 4

External Ids for IL17D Gene

Previous GeneCards Identifiers for IL17D Gene

  • GC13P019257
  • GC13P015257
  • GC13P020207
  • GC13P019075
  • GC13P020175
  • GC13P021276
  • GC13P002080

Summaries for IL17D Gene

Entrez Gene Summary for IL17D Gene

  • The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL17D Gene

IL17D (Interleukin 17D) is a Protein Coding gene. Diseases associated with IL17D include chronic mucocutaneous candidiasis. Among its related pathways are Jak-STAT signaling pathway and IL-17 Family Signaling Pathways. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL17B.

UniProtKB/Swiss-Prot for IL17D Gene

  • Induces expression of IL-6, IL-8, and GM-CSF from endothelial cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17D Gene

Genomics for IL17D Gene

Regulatory Elements for IL17D Gene

Enhancers for IL17D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL17D on UCSC Golden Path with GeneCards custom track

Promoters for IL17D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IL17D on UCSC Golden Path with GeneCards custom track

Genomic Location for IL17D Gene

Chromosome:
13
Start:
20,702,127 bp from pter
End:
20,723,100 bp from pter
Size:
20,974 bases
Orientation:
Plus strand

Genomic View for IL17D Gene

Genes around IL17D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17D Gene

Proteins for IL17D Gene

  • Protein details for IL17D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAD2-IL17D_HUMAN
    Recommended name:
    Interleukin-17D
    Protein Accession:
    Q8TAD2
    Secondary Accessions:
    • B1AM69

    Protein attributes for IL17D Gene

    Size:
    202 amino acids
    Molecular mass:
    21893 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IL17D Gene

Proteomics data for IL17D Gene at MOPED

Post-translational modifications for IL17D Gene

  • Glycosylation at Asn 68 and Asn 181
  • Modification sites at PhosphoSitePlus

Other Protein References for IL17D Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for IL17D

No data available for DME Specific Peptides for IL17D Gene

Domains & Families for IL17D Gene

Gene Families for IL17D Gene

Protein Domains for IL17D Gene

Suggested Antigen Peptide Sequences for IL17D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAD2

UniProtKB/Swiss-Prot:

IL17D_HUMAN :
  • Belongs to the IL-17 family.
Family:
  • Belongs to the IL-17 family.
genes like me logo Genes that share domains with IL17D: view

Function for IL17D Gene

Molecular function for IL17D Gene

UniProtKB/Swiss-Prot Function:
Induces expression of IL-6, IL-8, and GM-CSF from endothelial cells.
genes like me logo Genes that share phenotypes with IL17D: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IL17D

miRNA for IL17D Gene

miRTarBase miRNAs that target IL17D

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL17D Gene

Localization for IL17D Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17D Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL17D Gene COMPARTMENTS Subcellular localization image for IL17D gene
Compartment Confidence
extracellular 5
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for IL17D Gene

Pathways & Interactions for IL17D Gene

genes like me logo Genes that share pathways with IL17D: view

Pathways by source for IL17D Gene

1 BioSystems pathway for IL17D Gene
1 KEGG pathway for IL17D Gene
1 R&D Systems pathway for IL17D Gene

Interacting Proteins for IL17D Gene

Gene Ontology (GO) - Biological Process for IL17D Gene

None

No data available for SIGNOR curated interactions for IL17D Gene

Drugs & Compounds for IL17D Gene

No Compound Related Data Available

Transcripts for IL17D Gene

Unigene Clusters for IL17D Gene

Interleukin 17D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL17D Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - -

Relevant External Links for IL17D Gene

GeneLoc Exon Structure for
IL17D
ECgene alternative splicing isoforms for
IL17D

Expression for IL17D Gene

mRNA expression in normal human tissues for IL17D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL17D Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x4.7), Brain - Nucleus accumbens (basal ganglia) (x4.5), Brain - Putamen (basal ganglia) (x4.2), and Brain - Amygdala (x4.1).

Protein differential expression in normal tissues from HIPED for IL17D Gene

This gene is overexpressed in Heart (59.4) and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL17D Gene



SOURCE GeneReport for Unigene cluster for IL17D Gene Hs.655142

mRNA Expression by UniProt/SwissProt for IL17D Gene

Q8TAD2-IL17D_HUMAN
Tissue specificity: Expressed preferentially in adipose, skeletal muscle and CNS.
genes like me logo Genes that share expression patterns with IL17D: view

Protein tissue co-expression partners for IL17D Gene

Primer Products

Orthologs for IL17D Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL17D 35
  • 86.2 (n)
  • 85.48 (a)
IL17D 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il17d 35
  • 84.94 (n)
  • 86.8 (a)
Il17d 16
Il17d 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL17D 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL17D 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL17D 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL17D 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL17D 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il17d 35
  • 70.24 (n)
  • 70.24 (a)
zebrafish
(Danio rerio)
Actinopterygii il17d 35
  • 66.44 (n)
  • 69.39 (a)
il17d 36
  • 51 (a)
OneToOne
Species with no ortholog for IL17D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL17D Gene

ENSEMBL:
Gene Tree for IL17D (if available)
TreeFam:
Gene Tree for IL17D (if available)

Paralogs for IL17D Gene

Paralogs for IL17D Gene

genes like me logo Genes that share paralogs with IL17D: view

Variants for IL17D Gene

Sequence variations from dbSNP and Humsavar for IL17D Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs6783 -- 20,722,911(+) CAGGC(C/T)GAATA utr-variant-3-prime
rs7787 -- 20,723,059(+) GTTAG(A/T)AGTTC utr-variant-3-prime
rs735539 -- 20,705,895(-) TTCTT(C/T)AATGA intron-variant
rs1075690 -- 20,705,551(+) GATTA(A/G)CGAAG intron-variant
rs1888001 -- 20,711,767(-) TTCTT(C/G)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL17D Gene

Variant ID Type Subtype PubMed ID
nsv832558 CNV Loss 17160897

Variation tolerance for IL17D Gene

Residual Variation Intolerance Score: 79.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL17D Gene

HapMap Linkage Disequilibrium report
IL17D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17D Gene

Disorders for IL17D Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL17D Gene - From: GeneCards

Disorder Aliases PubMed IDs
chronic mucocutaneous candidiasis
  • cmc
- elite association - COSMIC cancer census association via MalaCards
Search IL17D in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL17D

Human Genome Epidemiology (HuGE) Navigator
IL17D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL17D
genes like me logo Genes that share disorders with IL17D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL17D Gene

Publications for IL17D Gene

  1. Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis. (PMID: 12097364) Starnes T. … Hromas R. (J. Immunol. 2002) 2 3 4 67
  2. Interleukin-17D mediates tumor rejection through recruitment of natural killer cells. (PMID: 24794441) O'Sullivan T. … Bui J.D. (Cell Rep 2014) 3
  3. Genetic determinants of P wave duration and PR segment. (PMID: 24850809) Verweij N. … van der Harst P. (Circ Cardiovasc Genet 2014) 3
  4. GWAS of dental caries patterns in the permanent dentition. (PMID: 23064961) Shaffer J.R. … Marazita M.L. (J. Dent. Res. 2013) 3
  5. The effects of IL-17 upon human natural killer cells. (PMID: 23490420) Al Omar S. … Christmas S.E. (Cytokine 2013) 3

Products for IL17D Gene

Sources for IL17D Gene

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