External Ids for IL17C Gene
Previous GeneCards Identifiers for IL17C Gene
The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL17C Gene
IL17C (Interleukin 17C) is a Protein Coding gene. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and IL-17 Family Signaling Pathways. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL17F.
UniProtKB/Swiss-Prot for IL17C Gene
Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.