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Aliases for IL17C Gene

Aliases for IL17C Gene

  • Interleukin 17C 2 3
  • Cytokine CX2 3 4
  • IL-17C 3 4
  • Interleukin-17C 3
  • CX2 3

External Ids for IL17C Gene

Previous GeneCards Identifiers for IL17C Gene

  • GC16P080141
  • GC16P089673
  • GC16P088408
  • GC16P088449
  • GC16P087232
  • GC16P088705
  • GC16P074400

Summaries for IL17C Gene

Entrez Gene Summary for IL17C Gene

  • The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL17C Gene

IL17C (Interleukin 17C) is a Protein Coding gene. Diseases associated with IL17C include enthesitis-related arthritis and hyper ige syndrome. Among its related pathways are IL-17 Family Signaling Pathways and IL-17 Family Signaling Pathways. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL17A.

UniProtKB/Swiss-Prot for IL17C Gene

  • Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17C Gene

Genomics for IL17C Gene

Regulatory Elements for IL17C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IL17C Gene

Start:
88,638,591 bp from pter
End:
88,640,474 bp from pter
Size:
1,884 bases
Orientation:
Plus strand

Genomic View for IL17C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL17C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17C Gene

Proteins for IL17C Gene

  • Protein details for IL17C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0M4-IL17C_HUMAN
    Recommended name:
    Interleukin-17C
    Protein Accession:
    Q9P0M4
    Secondary Accessions:
    • Q3MIG8
    • Q9HC75

    Protein attributes for IL17C Gene

    Size:
    197 amino acids
    Molecular mass:
    21765 Da
    Quaternary structure:
    • Binds to a heterodimer formed by IL17RA and IL17RE

neXtProt entry for IL17C Gene

Proteomics data for IL17C Gene at MOPED

Post-translational modifications for IL17C Gene

No Post-translational modifications

Other Protein References for IL17C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IL17C Gene

Domains for IL17C Gene

Gene Families for IL17C Gene

HGNC:
  • IL :Interleukins and interleukin receptors

Protein Domains for IL17C Gene

Suggested Antigen Peptide Sequences for IL17C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P0M4

UniProtKB/Swiss-Prot:

IL17C_HUMAN :
  • Q9P0M4
Family:
  • Belongs to the IL-17 family.
genes like me logo Genes that share domains with IL17C: view

Function for IL17C Gene

Molecular function for IL17C Gene

GENATLAS Biochemistry: interleukin 17C,not detected in several adult tissues,not in activated T cells,not binding to the IL17 receptor
UniProtKB/Swiss-Prot Function: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
UniProtKB/Swiss-Prot Induction: Up-regulated by bacterial stimuli, including by lipopolysaccharides (LPS) in gut epithelial cell lines. This up-regulation may be mediated by Toll-like receptors TLR2 and TLR5. Up-regulated by various proinflammatory cytokines, including TNF, IL1B and IL17F. Up-regulation by IL17A in colon epithelial cells has been observed in some cases (PubMed:21993849), but not in others (PubMed:21993848).

Gene Ontology (GO) - Molecular Function for IL17C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with IL17C: view
genes like me logo Genes that share phenotypes with IL17C: view

Animal Models for IL17C Gene

MGI Knock Outs for IL17C:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL17C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IL17C Gene

Localization for IL17C Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17C Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL17C Gene COMPARTMENTS Subcellular localization image for IL17C gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IL17C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IL17C: view

Pathways for IL17C Gene

genes like me logo Genes that share pathways with IL17C: view

Pathways by source for IL17C Gene

1 BioSystems pathway for IL17C Gene
1 R&D Systems pathway for IL17C Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for IL17C Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000244241%0d%0a9606.ENSP00000320936%0d%0a9606.ENSP00000295980%0d%0a
Selected Interacting proteins: ENSP00000244241 for IL17C Gene via STRING

Gene Ontology (GO) - Biological Process for IL17C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0007166 cell surface receptor signaling pathway TAS 10639155
GO:0007267 cell-cell signaling TAS 10639155
GO:0030223 neutrophil differentiation IEA --
GO:1900017 positive regulation of cytokine production involved in inflammatory response IEA --
genes like me logo Genes that share ontologies with IL17C: view

Transcripts for IL17C Gene

mRNA/cDNA for IL17C Gene

(8) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL17C Gene

Interleukin 17C:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL17C

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IL17C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL17C Gene

No ASD Table

Relevant External Links for IL17C Gene

GeneLoc Exon Structure for
IL17C
ECgene alternative splicing isoforms for
IL17C

Expression for IL17C Gene

mRNA expression in normal human tissues for IL17C Gene

mRNA differential expression in normal tissues according to GTEx for IL17C Gene

This gene is overexpressed in Testis (5.6), Stomach (5.3), and Whole Blood (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IL17C Gene

SOURCE GeneReport for Unigene cluster for IL17C Gene Hs.278911

genes like me logo Genes that share expressions with IL17C: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IL17C Gene

Orthologs for IL17C Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL17C 35
  • 98.98 (n)
  • 99.49 (a)
IL17C 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL17C 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL17C 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il17c 35
  • 76.79 (n)
  • 77.49 (a)
Il17c 16
Il17c 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL17C 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL17C 36
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il17c 35
  • 74.87 (n)
  • 75.39 (a)
chicken
(Gallus gallus)
Aves IL17C 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL17C 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il17c 35
  • 50.6 (n)
  • 48.21 (a)
zebrafish
(Danio rerio)
Actinopterygii il17c 36
  • 28 (a)
OneToOne
Species with no ortholog for IL17C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL17C Gene

ENSEMBL:
Gene Tree for IL17C (if available)
TreeFam:
Gene Tree for IL17C (if available)

Paralogs for IL17C Gene

Paralogs for IL17C Gene

Selected SIMAP similar genes for IL17C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IL17C: view

Variants for IL17C Gene

Sequence variations from dbSNP and Humsavar for IL17C Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs869410 -- 88,639,545(-) GGTGA(A/C/T)GGGCC intron-variant
rs869411 -- 88,639,499(-) AGTGG(C/G)AGGCA intron-variant
rs899731 -- 88,637,351(+) CCTCA(C/T)TCACA upstream-variant-2KB
rs2254073 -- 88,639,396(+) CTTGG(C/T)GGTTC intron-variant
rs3073042 -- 88,637,742(+) aaCAA(-/AAA/AAAAAAA/AAAAAAACAA/AAAAAACAA)CACAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IL17C Gene

Variant ID Type Subtype PubMed ID
nsv907226 CNV Loss 21882294
nsv907255 CNV Loss 21882294
nsv907264 CNV Loss 21882294
nsv833325 CNV Loss 17160897
nsv907268 CNV Loss 21882294
dgv2977n71 CNV Loss 21882294
dgv2978n71 CNV Loss 21882294
dgv2979n71 CNV Loss 21882294
nsv907278 CNV Loss 21882294
nsv1926 CNV Insertion 18451855
dgv2980n71 CNV Loss 21882294

Relevant External Links for IL17C Gene

HapMap Linkage Disequilibrium report
IL17C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17C Gene

Disorders for IL17C Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for IL17C Gene including...

Search for IL17C Gene in MalaCards »

(2) Novoseek inferred disease relationships for IL17C Gene

Disease -log(P) Hits PubMed IDs
autoimmunity 51.4 6
inflammation 30.4 1

Relevant External Links for IL17C

Genetic Association Database (GAD)
IL17C
Human Genome Epidemiology (HuGE) Navigator
IL17C
genes like me logo Genes that share disorders with IL17C: view

No data available for UniProtKB/Swiss-Prot for IL17C Gene

Publications for IL17C Gene

  1. Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. (PMID: 10639155) Li H. … Wood W.I. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 48
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 48

Products for IL17C Gene

  • antibodies-online proteins for IL17C
  • antibodies-online antibodies for IL17C
  • antibodies-online kits for IL17C

Sources for IL17C Gene

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