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IL17C Gene

protein-coding   GIFtS: 53
GCID: GC16P088705

Interleukin 17C

  See IL17C-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Interleukin 17C1 2
Cytokine CX22 3
IL-17C2 3
CX22
interleukin-17C2

External Ids:    HGNC: 59831   Entrez Gene: 271892   Ensembl: ENSG000001243917   OMIM: 6046285   UniProtKB: Q9P0M43   
ORGUL members:         

Export aliases for IL17C gene to outside databases

Previous GC identifers: GC16P080141 GC16P089673 GC16P088408 GC16P088449 GC16P087232 GC16P074400


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL17C Gene:
The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This
cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a
monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. (provided
by RefSeq, Jul 2008)

GeneCards Summary for IL17C Gene:
IL17C (interleukin 17C) is a protein-coding gene. Diseases associated with IL17C include enthesitis-related arthritis, and hyper ige syndrome. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL17A.

UniProtKB/Swiss-Prot: IL17C_HUMAN, Q9P0M4
Function: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal
bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and
proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts
synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and
REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of
insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an
inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to
greater susceptibility to autoimmune diseases




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL17C gene promoter:
         AhR   MAZR   p53   HTF   CUTL1   Arnt   Gfi-1   AREB6   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL17C promoter sequence
   Search Chromatin IP Primers for IL17C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL17C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24

IL17C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL17C gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P088705:  view genomic region     (about GC identifiers)

Start:
88,704,999 bp from pter      End:
88,706,882 bp from pter
Size:
1,884 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL17C_HUMAN, Q9P0M4 (See protein sequence)
Recommended Name: Interleukin-17C precursor  
Size: 197 amino acids; 21765 Da
Subunit: Binds to a heterodimer formed by IL17RA and IL17RE
Secondary accessions: Q3MIG8 Q9HC75

Explore the universe of human proteins at neXtProt for IL17C: NX_Q9P0M4

REFSEQ proteins: NP_037410.1  
ENSEMBL proteins: 
 ENSP00000244241  

IL17C Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
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OriGene Purified Protein for IL17C
OriGene Protein Over-expression Lysate for IL17C
OriGene MassSpec for IL17C
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Novus Biologicals IL17C Proteins
Novus Biologicals IL17C Lysates
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Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for IL17C

 
eBioscience Proteins for IL17C: (see all 2
                    Human IL-17C Recombinant Protein 5 ug

IL17C Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for IL17C (IL-17C)
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Abcam antibodies for IL17C
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ThermoFisher Antibodies for IL17C
LSBio Antibodies in human, mouse, rat for IL17C

IL17C Assay Products:

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Cloud-Clone Corp. ELISAs for IL17C
Cloud-Clone Corp. CLIAs for IL17C
Search eBioscience for ELISAs for IL17C 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
IL: Interleukins and interleukin receptors

2 InterPro protein domains:
 IPR010345 IL-17_fam
 IPR020440 IL-17_chr

Graphical View of Domain Structure for InterPro Entry Q9P0M4

ProtoNet protein and cluster: Q9P0M4

1 Blocks protein domain: IPB010345 Interleukin-17

UniProtKB/Swiss-Prot: IL17C_HUMAN, Q9P0M4
Similarity: Belongs to the IL-17 family


Find genes that share domains with IL17C           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: IL17C_HUMAN, Q9P0M4
Function: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal
bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and
proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts
synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and
REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of
insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an
inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to
greater susceptibility to autoimmune diseases
Induction: Up-regulated by bacterial stimuli, including by lipopolysaccharides (LPS) in gut epithelial cell lines.
This up-regulation may be mediated by Toll-like receptors TLR2 and TLR5. Up-regulated by various proinflammatory
cytokines, including TNF, IL1B and IL17F. Up-regulation by IL17A in colon epithelial cells has been observed in
some cases (PubMed:21993849), but not in others (PubMed:21993848)

     Genatlas biochemistry entry for IL17C:
interleukin 17C,not detected in several adult tissues,not in activated T cells,not binding to the IL17 receptor

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
     
Find genes that share ontologies with IL17C           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for IL17C:
 Decreased Salmonella enterica   Increased S DNA content 

     6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Il17c):
 cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
 integument 

Find genes that share phenotypes with IL17C           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Il17ctm1Lex for IL17C

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL17C
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL17C

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL17C
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL17C

miRNA
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Block miRNA regulation of human, mouse, rat IL17C using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate IL17C:
hsa-miR-466
SwitchGear 3'UTR luciferase reporter plasmidIL17C 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for IL17C
Predesigned siRNA for gene silencing in human, mouse, rat IL17C

Gene Editing
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DNA2.0 Custom Protein Engineering Service for IL17C

Clone
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OriGene ORF clones in mouse, rat for IL17C
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL17C (NM_013278)
Sino Biological Human cDNA Clone for IL17C
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL17C
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL17C

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IL17C
Browse ESI BIO Cell Lines and PureStem Progenitors for IL17C 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17C


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
IL17C_HUMAN, Q9P0M4: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
nucleus2
cytosol1
mitochondrion1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space IEA--

Find genes that share ontologies with IL17C           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IL17C About    
See pathways by source

SuperPathContained pathways About
1IL-17 Family Signaling Pathways
IL-17 Family Signaling Pathways0.51
IL17 signaling pathway0.51

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for IL17C
    IL-17 Family Signaling Pathways


1 BioSystems Pathway for IL17C
    IL17 signaling pathway



    Pathway & Disease-focused RT2 Profiler PCR Arrays including IL17C: 
          Th17 Response in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Common Cytokines in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for IL17C

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for IL17C (ENSP000002442414) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IL17RAENSP000003209364STRING: ENSP00000320936
IL17REENSP000002959804STRING: ENSP00000295980
IL17RBENSP000002881674STRING: ENSP00000288167
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006954inflammatory response IEA--
GO:0007166cell surface receptor signaling pathway TAS10639155
GO:0007267cell-cell signaling TAS10639155
GO:0030223neutrophil differentiation IEA--
GO:1900017positive regulation of cytokine production involved in inflammatory response IEA--

Find genes that share ontologies with IL17C           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for IL17C



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for IL17C gene: 
NM_013278.3  

Unigene Cluster for IL17C:

Interleukin 17C
Hs.278911  [show with all ESTs]
Unigene Representative Sequence: NM_013278
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000569133 ENST00000244241(uc002fla.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat IL17C using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate IL17C:
hsa-miR-466
SwitchGear 3'UTR luciferase reporter plasmidIL17C 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for IL17C
Predesigned siRNA for gene silencing in human, mouse, rat IL17C
Clone
Products:
     
OriGene clones in human, mouse for IL17C (see all 5)
OriGene ORF clones in mouse, rat for IL17C
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL17C (NM_013278)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL17C
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL17C
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for IL17C
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL17C
  QuantiTect SYBR Green Assays in human, mouse, rat IL17C
  QuantiFast Probe-based Assays in human, mouse, rat IL17C

Additional mRNA sequence: 

AF152099.1 AY358471.1 BC069152.1 BC069410.1 BC101835.1 BC112196.1 

1 DOTS entry:

DT.91697776 

8 AceView cDNA sequences:

BX281422 BC069152 AF152099 AY358471 NM_013278 BC069410 AF142410 BE551188 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IL17C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IL17C Expression
About this image

IL17C Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.278911
    Pathway & Disease-focused RT2 Profiler PCR Arrays including IL17C: 
          Th17 Response in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Common Cytokines in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for IL17C
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL17C
QuantiTect SYBR Green Assays in human, mouse, rat IL17C
QuantiFast Probe-based Assays in human, mouse, rat IL17C
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17C

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for IL17C gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il17c1 , 5 interleukin 17C1, 5 76.79(n)1
77.49(a)1
  8 (71.03 cM)5
2348361  NM_145834.31  NP_665833.31 
 1224220855 
chicken
(Gallus gallus)
Aves IL17C6
interleukin 17C
48(a)
1 ↔ 1
11(17890560-17892594)
lizard
(Anolis carolinensis)
Reptilia IL17C6
interleukin 17C
41(a)
1 ↔ 1
GL343670.1(90644-93974)
tropical clawed frog
(Xenopus tropicalis)
Amphibia il17c1 interleukin 17C 50.6(n)
48.21(a)
  100489383  XM_002941995.2  XP_002942041.2 
zebrafish
(Danio rerio)
Actinopterygii il17c6
interleukin 17c
28(a)
1 ↔ 1
18(16735153-16736764) ENSDARG00000057180


ENSEMBL Gene Tree for IL17C (if available)
TreeFam Gene Tree for IL17C (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for IL17C gene
IL17A2  IL17F2  
1 SIMAP similar gene for IL17C using alignment to 1 protein entry:     IL17C_HUMAN:
IL17F

Find genes that share paralogs with IL17C           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IL17C (see all 190)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1844087211,2
--88703016(+) CCACGA/GCCTCG 1 -- us2k10--------
rs116465421,2
C,F,A,H--88703061(+) TTGTGT/GTGCAT 1 -- us2k1 tfbs311Minor allele frequency- G:0.49NA WA CSA EA 374
rs1441791101,2
C--88703095(+) AGCACA/GGATAG 1 -- us2k10--------
rs99372571,2
C,F,A,H--88703223(+) CTGGGG/ACACAG 1 -- us2k119Minor allele frequency- A:0.27NS EA NA CSA WA 2342
rs1888044661,2
--88703236(+) TCCTTC/TACCCC 1 -- us2k10--------
rs797854651,2
F--88703279(+) ACAGCG/AGCCAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs1163191431,2
C--88703441(+) ACACAA/GGCACC 1 -- us2k10--------
rs1865405981,2
--88703659(+) CTCACC/TGATCA 1 -- us2k10--------
rs1482671041,2
--88703692(+) GCCCCA/GCTTAC 1 -- us2k10--------
rs1909432991,2
--88703732(+) CTCACA/GCCTCA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for IL17C (88704999 - 88706882 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for IL17C (see all 11):    About this table    
Variant IDTypeSubtypePubMed ID
nsv1926CNV Insertion18451855
dgv2980n71CNV Loss21882294
nsv907278CNV Loss21882294
dgv2977n71CNV Loss21882294
nsv907268CNV Loss21882294
nsv907264CNV Loss21882294
nsv907255CNV Loss21882294
dgv2978n71CNV Loss21882294
dgv2979n71CNV Loss21882294
nsv907226CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing IL17C
DNA2.0 Custom Variant and Variant Library Synthesis for IL17C

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604628    OMIM disorders: --

3 diseases for IL17C:    
About MalaCards
enthesitis-related arthritis    hyper ige syndrome    childhood leukemia


Find genes that share disorders with IL17C           About GenesLikeMe

2 Novoseek inferred disease relationships for IL17C gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
autoimmunity 51.4 6 19546505 (5), 19604260 (1)
inflammation 30.4 1 19604260 (1)

Genetic Association Database (GAD): IL17C
Human Genome Epidemiology (HuGE) Navigator: IL17C (12 documents)

Export disorders for IL17C gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IL17C gene, integrated from 10 sources (see all 51):
(articles sorted by number of sources associating them with IL17C)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. (PubMed id 10639155)1, 2, 3, 9 Li H.... Wood W.I. (Proc. Natl. Acad. Sci. U.S.A. 2000)
  2. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. (PubMed id 21993848)1, 2 Ramirez-Carrozzi V.... Pappu R. (Nat. Immunol. 2011)
  3. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
  4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
  6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  9. The pattern recognition receptor NOD2 mediates Staphylococcus aureus-induced IL-17C expression in keratinocytes. (PubMed id 23892590)1 Roth S.A....Harder J. (J. Invest. Dermatol. 2014)
  10. IL-17C is a mediator of respiratory epithelial innate immune response. (PubMed id 23221046)1 Pfeifer P....Beisswenger C. (Am. J. Respir. Cell Mol. Biol. 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 27189 HGNC: 5983 AceView: IL17C Ensembl:ENSG00000124391 euGenes: HUgn27189
ECgene: IL17C H-InvDB: IL17C

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IL17C Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL17C Genetics and Cytogenetics in Oncology and Haematology
Wikipedia http://en.wikipedia.org/wiki/Interleukin_17

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IP news from LifeMap Sciences, Inc.)
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Patent Information for IL17C gene:
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