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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL17C Gene

protein-coding   GIFtS: 52
GCID: GC16P088705

Interleukin 17C

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 17C1 2
Cytokine CX22 3
IL-17C2 3
CX22
IL-212
interleukin-17C2

External Ids:    HGNC: 59831   Entrez Gene: 271892   Ensembl: ENSG000001243917   OMIM: 6046285   UniProtKB: Q9P0M43   

Export aliases for IL17C gene to outside databases

Previous GC identifers: GC16P080141 GC16P089673 GC16P088408 GC16P088449 GC16P087232 GC16P074400


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL17C Gene:
The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This
cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a
monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. (provided
by RefSeq, Jul 2008)

GeneCards Summary for IL17C Gene: 
IL17C (interleukin 17C) is a protein-coding gene. Diseases associated with IL17C include hyper ige syndrome, and chronic lymphocytic leukemia, and among its related super-pathways are Mucin expression in CF via IL-6, IL-17 signaling pathways. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL17A.

UniProtKB/Swiss-Prot: IL17C_HUMAN, Q9P0M4
Function: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal
bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and
proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts
synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and
REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of
insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an
inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to
greater susceptibility to autoimmune diseases




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010542.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL17C gene promoter:
         AhR   MAZR   p53   HTF   CUTL1   Arnt   Gfi-1   AREB6   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL17C promoter sequence
   Search SABiosciences Chromatin IP Primers for IL17C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL17C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24

IL17C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL17C gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P088705:  view genomic region     (about GC identifiers)

Start:
88,704,999 bp from pter      End:
88,706,882 bp from pter
Size:
1,884 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL17C_HUMAN, Q9P0M4 (See protein sequence)
Recommended Name: Interleukin-17C precursor  
Size: 197 amino acids; 21765 Da
Subunit: Binds to a heterodimer formed by IL17RA and IL17RE
Subcellular location: Secreted
Secondary accessions: Q3MIG8 Q9HC75

Explore the universe of human proteins at neXtProt for IL17C: NX_Q9P0M4

IL17C Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_037410.1  
ENSEMBL proteins: 
 ENSP00000244241  

Human Recombinant Protein Products for IL17C: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for IL17C (IL-17C)
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for IL17C
OriGene Protein Over-expression Lysate for IL17C
OriGene MassSpec for IL17C 
OriGene Custom Protein Services for IL17C
GenScript Custom Purified and Recombinant Proteins Services for IL17C
Novus Biologicals IL17C Proteins
Novus Biologicals IL17C Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for IL17C 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space IEA--

IL17C for ontologies           About GeneDecksing



IL17C Antibody Products: 
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Cloud-Clone Corp. Antibodies for IL17C 
ThermoFisher Antibodies for IL17C
LSBio Antibodies in human, mouse, rat for IL17C 

Assay Products for IL17C: 
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R&D Systems ELISAs for IL17C (IL-17C)
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Cloud-Clone Corp. ELISAs for IL17C 
Cloud-Clone Corp. CLIAs for IL17C


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IL: Interleukins and interleukin receptors

2 InterPro protein domains:
 IPR010345 Interleukin-17
 IPR020440 Interleukin-17_chordata

Graphical View of Domain Structure for InterPro Entry Q9P0M4

ProtoNet protein and cluster: Q9P0M4

1 Blocks protein domain: IPB010345 Interleukin-17

UniProtKB/Swiss-Prot: IL17C_HUMAN, Q9P0M4
Similarity: Belongs to the IL-17 family


IL17C for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: IL17C_HUMAN, Q9P0M4
Function: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal
bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and
proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts
synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and
REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of
insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an
inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to
greater susceptibility to autoimmune diseases
Induction: Up-regulated by bacterial stimuli, including by lipopolysaccharides (LPS) in gut epithelial cell lines.
This up-regulation may be mediated by Toll-like receptors TLR2 and TLR5. Up-regulated by various proinflammatory
cytokines, including TNF, IL1B and IL17F. Up-regulation by IL17A in colon epithelial cells has been observed in
some cases (PubMed:21993849), but not in others (PubMed:21993848)

     Genatlas biochemistry entry for IL17C:
interleukin 17C,not detected in several adult tissues,not in activated T cells,not binding to the IL17 receptor

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
     
IL17C for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for IL17C:
 Decreased Salmonella enterica   Increased S DNA content 

     6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Il17c):
 cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
 integument 

IL17C for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Il17ctm1Lex for IL17C

   inGenious Targeting Laboratory - Custom generated mouse model solutions for IL17C 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL17C

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL17C 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL17C 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL17C
1 QIAGEN miScript miRNA Assays for microRNA that regulate IL17C:
hsa-miR-466
SwitchGear 3'UTR luciferase reporter plasmidIL17C 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL17C
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL17C

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IL17C
Sirion Biotech Customized adenovirus for overexpression of IL17C

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for IL17C (see all 6)
OriGene ORF clones in mouse, rat for IL17C
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL17C (NM_013278)
Sino Biological Human cDNA Clone for IL17C
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL17C
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL17C
Sirion Biotech Customized lentivirus for stable overexpression of IL17C 
                     Customized lentivirus expression plasmids for stable overexpression of IL17C 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IL17C
Search LifeMap BioReagents cell lines for IL17C
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17C


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IL17C About                                                                                                See pathways by source

SuperPathContained pathways About
1Mucin expression in CF via IL-6, IL-17 signaling pathways
IL-17 Signaling0.48

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 R&D Systems Pathway for IL17C
    IL-17 Signaling




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IL17C

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for IL17C (ENSP000002442414) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IL17RAENSP000003209364STRING: ENSP00000320936
IL17REENSP000002959804STRING: ENSP00000295980
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006954inflammatory response IEA--
GO:0007166cell surface receptor signaling pathway TAS10639155
GO:0007267cell-cell signaling TAS10639155
GO:0030223neutrophil differentiation IEA--
GO:1900017positive regulation of cytokine production involved in inflammatory response IEA--

IL17C for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL17C

Search CenterWatch for drugs/clinical trials and news about IL17C

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL17C gene: 
NM_013278.3  

Unigene Cluster for IL17C:

Interleukin 17C
Hs.278911  [show with all ESTs]
Unigene Representative Sequence: NM_013278
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000569133 ENST00000244241(uc002fla.3)
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL17C
1 QIAGEN miScript miRNA Assays for microRNA that regulate IL17C:
hsa-miR-466
SwitchGear 3'UTR luciferase reporter plasmidIL17C 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL17C
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL17C
Clone
Products:
     
OriGene clones in human, mouse for IL17C (see all 6)
OriGene ORF clones in mouse, rat for IL17C
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL17C (NM_013278)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL17C
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL17C
Sirion Biotech Customized lentivirus for stable overexpression of IL17C 
                     Customized lentivirus expression plasmids for stable overexpression of IL17C 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for IL17C
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL17C
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL17C
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL17C

Additional mRNA sequence: 

AF152099.1 AY358471.1 BC069152.1 BC069410.1 BC101835.1 BC112196.1 

1 DOTS entry:

DT.91697776 

8 AceView cDNA sequences:

BX281422 BC069152 AY358471 NM_013278 BC069410 AF152099 AF142410 BE551188 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL17C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IL17C Expression
About this image


Genevestigator expression for IL17C

SOURCE GeneReport for Unigene cluster: Hs.278911
    SABiosciences Expression via Pathway-Focused PCR Arrays including IL17C: 
          Th17 Response in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat
          Common Cytokines in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for IL17C
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL17C
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL17C
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL17C
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17C

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL17C gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il17c1 , 5 interleukin 17C1, 5 77.19(n)1
77.89(a)1
  8 (71.03 cM)5
2348361  NM_145834.31  NP_665833.31 
 1224220855 
chicken
(Gallus gallus)
Aves LOC1008590401 interleukin-17C-like 62.66(n)
54.1(a)
  100859040  XM_003641945.1  XP_003641993.1 
lizard
(Anolis carolinensis)
Reptilia IL17C6
Uncharacterized protein
43(a)
1 ↔ 1
GL343670.1(90644-93974)
zebrafish
(Danio rerio)
Actinopterygii il17c6
interleukin 17c
25(a)
1 ↔ 1
18(16735153-16736764)


ENSEMBL Gene Tree for IL17C (if available)
TreeFam Gene Tree for IL17C (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IL17C gene
IL17A2  IL17F2  
1 SIMAP similar gene for IL17C using alignment to 1 protein entry:     IL17C_HUMAN:
IL17F

IL17C for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/190 SNPs in IL17C are shown (see all 190)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1844087211,2
--88703016(+) CCACGA/GCCTCG 1 -- us2k10--------
rs116465421,2
C,F,A,H--88703061(+) TTGTGT/GTGCAT 1 -- us2k1 tfbs311Minor allele frequency- G:0.49NA WA CSA EA 374
rs1441791101,2
C--88703095(+) AGCACA/GGATAG 1 -- us2k10--------
rs99372571,2
C,F,A,H--88703223(+) CTGGGG/ACACAG 1 -- us2k119Minor allele frequency- A:0.27NS EA NA CSA WA 2342
rs1888044661,2
--88703236(+) TCCTTC/TACCCC 1 -- us2k10--------
rs797854651,2
F--88703279(+) ACAGCG/AGCCAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs1163191431,2
C--88703441(+) ACACAA/GGCACC 1 -- us2k10--------
rs1865405981,2
--88703659(+) CTCACC/TGATCA 1 -- us2k10--------
rs1482671041,2
--88703692(+) GCCCCA/GCTTAC 1 -- us2k10--------
rs1909432991,2
--88703732(+) CTCACA/GCCTCA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for IL17C (88704999 - 88706882 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/11 variations for IL17C (see all 11):    About this table     
Variant IDTypeSubtypePubMed ID
nsv1926CNV Insertion18451855
dgv2980n71CNV Loss21882294
nsv907278CNV Loss21882294
dgv2977n71CNV Loss21882294
nsv907268CNV Loss21882294
nsv907264CNV Loss21882294
nsv907255CNV Loss21882294
dgv2978n71CNV Loss21882294
dgv2979n71CNV Loss21882294
nsv907226CNV Loss21882294

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing IL17C
DNA2.0 Custom Variant and Variant Library Synthesis for IL17C

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 604628    OMIM disorders: --

12 diseases for IL17C:    About MalaCards
hyper ige syndrome    chronic lymphocytic leukemia    systemic lupus erythematosus    encephalomyelitis
meningioma    multiple sclerosis    hepatitis b    lupus erythematosus
rheumatoid arthritis    arthritis    hepatitis    leukemia


IL17C for disorders           About GeneDecksing

2 Novoseek inferred disease relationships for IL17C gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
autoimmunity 51.4 6 19546505 (5), 19604260 (1)
inflammation 30.4 1 19604260 (1)

Genetic Association Database (GAD): IL17C
Human Genome Epidemiology (HuGE) Navigator: IL17C (12 documents)

Export disorders for IL17C gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IL17C gene, integrated from 9 sources (see all 49):
(articles sorted by number of sources associating them with IL17C)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. (PubMed id 10639155)1, 2, 3, 9 Li H.... Wood W.I. (2000)
  2. IL-17C regulates the innate immune function of epithel ial cells in an autocrine manner. (PubMed id 21993848)1, 2 Ramirez-Carrozzi V....Pappu R. (2011)
  3. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
  4. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
  5. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
  6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  9. IL-17C is a mediator of respiratory epithelial innate immune response. (PubMed id 23221046)1 Pfeifer P....Beisswenger C. (2013)
  10. Keratinocyte overexpression of IL-17C promotes psorias iform skin inflammation. (PubMed id 23359500)1 Johnston A....Ward N.L. (2013)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 27189 HGNC: 5983 AceView: IL17C Ensembl:ENSG00000124391 euGenes: HUgn27189
ECgene: IL17C H-InvDB: IL17C

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IL17C Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL17C Genetics and Cytogenetics in Oncology and Haematology
Wikipedia http://en.wikipedia.org/wiki/Interleukin_17

(Patent information from GeneIP,
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IP news from LifeMap Sciences, Inc.)
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Patent Information for IL17C gene:
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