IL17C Gene
protein-coding GIFtS: 48
GCID: GC16P088705
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interleukin 17C
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Aliases
for IL17C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interleukin 17C1 2 | | Cytokine CX22 3 | | IL-17C1 2 3 | | MGC1268841 | | CX21 2 | | MGC1384011 | | IL-211 2 | | Interleukin-17C1 |
Export aliases for IL17C gene to outside databasesPrevious GC identifers: GC16P080141 GC16P089673 GC16P088408 GC16P088449 GC16P087232 GC16P074400 |
Summaries
for IL17C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IL17C:
The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. Thiscytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocyticcell line. The expression of this cytokine was found to be restricted to activated T cells. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: IL17C_HUMAN, Q9P0M4Function: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterialpathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory moleculesfor host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing theexpression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF andIL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenicproperties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatoryphenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases
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Genomic Views
for IL17C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010542.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IL17C gene promoter:
AhR MAZR p53 HTF CUTL1 Arnt Gfi-1 AREB6 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for IL17C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL17C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q24 Ensembl cytogenetic band: 16q24.3 HGNC cytogenetic band: 16q24IL17C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P088705: view genomic region
(about GC identifiers)
Start:
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88,704,999 bp from pter |
End:
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88,706,882 bp from pter |
Size:
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1,884 bases |
Orientation:
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plus strand |
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Proteins
for IL17C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IL17C_HUMAN, Q9P0M4 (See
protein sequence)Recommended Name: Interleukin-17C precursor Size: 197 amino acids; 21765 Da
Subunit: Binds to a heterodimer formed by IL17RA and IL17RE
Subcellular location: Secreted
Secondary accessions: Q3MIG8 Q9HC75Explore the universe of human proteins at neXtProt for IL17C: NX_Q9P0M4
IL17C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_037410.1
ENSEMBL proteins: ENSP00000244241
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005615 | extracellular space |
IEA | -- | | GO:0005625 | soluble fraction |
-- | -- |
IL17C for ontologies About GeneDecksing
IL17C Antibody Products:
Assay Products for IL17C: |
Protein
Domains /
Families
for IL17C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IL17C for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P0M4ProtoNet protein and cluster: Q9P0M4 1 Blocks protein family: IPB010345 Interleukin-17
UniProtKB/Swiss-Prot: IL17C_HUMAN, Q9P0M4Similarity: Belongs to the IL-17 family |
Function
for IL17C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IL17C_HUMAN, Q9P0M4Function: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterialpathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory moleculesfor host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing theexpression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF andIL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenicproperties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatoryphenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseasesInduction: Up-regulated by bacterial stimuli, including by lipopolysaccharides (LPS) in gut epithelial cell lines. Thisup-regulation may be mediated by Toll-like receptors TLR2 and TLR5. Up-regulated by various proinflammatory cytokines,including TNF, IL1B and IL17F. Up-regulation by IL17A in colon epithelial cells has been observed in some cases(PubMed:21993849), but not in others (PubMed:21993848) Genatlas biochemistry entry for IL17C:interleukin 17C,not detected in several adult tissues,not in activated T cells,not binding to the IL17 receptor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL17C (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL17C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for IL17C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL17C |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005125 | cytokine activity |
IEA | -- |
IL17C for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for IL17C:
Animal Models:
Mouse knock-out Il17ctm1Lex for IL17C
6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Il17c):
IL17C for phenotypes About GeneDecksing
|
Pathways & Interactions
for IL17C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IL17C
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for IL17C (ENSP000002442414) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
IL17C for ontologies About GeneDecksing
|
Drugs & Compounds
for IL17C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IL17C
Search CenterWatch for drugs/clinical trials and news about IL17C
|
Transcripts
for IL17C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IL17C gene: NM_013278.3 Unigene Cluster for IL17C: Interleukin 17C Hs.278911 [show with all ESTs]Unigene Representative Sequence: NM_0132782 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000569133 ENST00000244241(uc002fla.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL17C (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL17C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IL17C (NM_013278) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL17C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL17C |
Additional cDNA sequence: AF152099.1 AY358471.1 BC069152.1 BC069410.1 BC101835.1 BC112196.1 1 DOTS entry: DT.91697776 8 AceView cDNA sequences: BX281422 BC069152 AF152099 AY358471 NM_013278 BC069410 AF142410 BE551188
GeneLoc Exon Structure
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Expression
for IL17C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IL17C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See IL17C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL17C
SOURCE GeneReport for Unigene cluster: Hs.278911
SABiosciences Expression via Pathway-Focused PCR Arrays including IL17C:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL17C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL17C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL17C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL17C |
Orthologs
for IL17C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IL17C gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for IL17C (if available)
TreeFam Gene Tree for IL17C (if available) |
Paralogs
for IL17C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IL17C gene
- IL17A2 IL17D2 IL17F2 IL17B2
1 SIMAP similar gene for IL17C using alignment to 1 protein entry: IL17C_HUMAN:IL17F
IL17C for paralogs About GeneDecksing
|
Genomic Variants
for IL17C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IL17C (88704999 - 88706882 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IL17C
1 CNV: 4973 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL17C |
|
Disorders
/ Diseases
for IL17C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IL17C for disorders About GeneDecksing
OMIM gene information: 604628
OMIM disorders: --
14  diseases for IL17C: About MalaCardshyper-ige syndrome systemic lupus erythematosus lupus erythematosus chronic lymphocytic leukemia
lymphocytic leukemia rheumatoid arthritis multiple sclerosis encephalomyelitis
hepatitis b arthritis meningioma leukemia
hepatitis fibrosis
2 Novoseek disease relationships for IL17C gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| autoimmunity |
51.4 |
6 |
19546505 (5), 19604260 (1) |
| inflammation |
30.4 |
1 |
19604260 (1) |
Human Genome Epidemiology (HuGE) Navigator: IL17C (12 documents)
Export disorders for IL17C gene to outside databases
|
Publications
for IL17C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IL17C gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with IL17C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. (PubMed id 10639155)1, 2, 3, 9 Li H.... Wood W.I. (2000)
- IL-17C regulates the innate immune function of epithel ial cells in an autocrine manner. (PubMed id 21993848)1, 2 Ramirez-Carrozzi V....Pappu R. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Alterations in methylation status of immune response g enes promoters in cell-free DNA during a hemodialysis procedure. (PubMed id 22506826)1 Korabecna M....Tesar V. (2012)
- Tumor necrosis factor I+-mediated induction of interle ukin 17C in human keratinocytes is controlled by nuclear factor I_B. (PubMed id 21628458)1 Johansen C....Iversen L. (2011)
- IL-17RE is the functional receptor for IL-17C and medi ates mucosal immunity to infection with intestinal pathogens. (PubMed id 21993849)2 Song X....Qian Y. (2011)
- Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (2010)
- Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1 Rajaraman P....Inskip P.D. (2010)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
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External Searches for IL17C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IL17C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IL17C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IL17C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for IL17C gene:
Search GeneIP for patents involving IL17C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IL17C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IL17C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL17C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL17C | | | OriGene Protein Over-expression Lysate for IL17C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IL17C | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL17C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL17C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for IL17C | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IL17C | | OriGene Custom Protein Services for IL17C | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL17C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL17C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL17C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL17C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL17C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL17C |
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 | | | IL17C Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for IL17C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL17C |
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