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IL17B Gene

protein-coding   GIFtS: 54
GCID: GC05M148734

Interleukin 17B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 17B1 2     Interleukin 202
Neuronal Interleukin-17-Related Factor1 2 3     Interleukin-17 Beta2
Cytokine Zcyto72 3     interleukin-17B2
IL-17B2 3     interleukin-202
IL-202 3     Neuronal Interleukin-17 Related Factor2
NIRF2 3     IL203
ZCYTO72 3     Interleukin-203
Cytokine-Like Protein ZCYTO72     

External Ids:    HGNC: 59821   Entrez Gene: 271902   Ensembl: ENSG000001277437   OMIM: 6046275   UniProtKB: Q9UHF53   

Export aliases for IL17B gene to outside databases

Previous GC identifers: GC05M148797 GC05M149348 GC05M148782 GC05M143900


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL17B Gene:
The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This
cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line.
Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to
neuronal cell bodies. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL17B Gene:
IL17B (interleukin 17B) is a protein-coding gene. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL17D.

UniProtKB/Swiss-Prot: IL17B_HUMAN, Q9UHF5
Function: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL17B gene promoter:
         AREB6   HEN1   GR   Ik-2   GR-beta   c-Myb   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL17B promoter sequence
   Search Chromatin IP Primers for IL17B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL17B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.1   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q33.1

IL17B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL17B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M148734:  view genomic region     (about GC identifiers)

Start:
148,750,887 bp from pter      End:
148,783,765 bp from pter
Size:
32,879 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL17B_HUMAN, Q9UHF5 (See protein sequence)
Recommended Name: Interleukin-17B precursor  
Size: 180 amino acids; 20437 Da
Secondary accessions: Q14CE5

Explore the universe of human proteins at neXtProt for IL17B: NX_Q9UHF5

Explore proteomics data for IL17B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn75

  • See IL17B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055258.1  
    ENSEMBL proteins: 
     ENSP00000261796  

    IL17B Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for IL17B
    Cloud-Clone Corp. Proteins for IL17B

     
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    LSBio Antibodies in human, mouse, rat for IL17B

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    Search eBioscience for ELISAs for IL17B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    2 InterPro protein domains:
     IPR010345 IL-17_fam
     IPR020440 IL-17_chr

    Graphical View of Domain Structure for InterPro Entry Q9UHF5

    ProtoNet protein and cluster: Q9UHF5

    1 Blocks protein domain: IPB010345 Interleukin-17

    UniProtKB/Swiss-Prot: IL17B_HUMAN, Q9UHF5
    Similarity: Belongs to the IL-17 family


    Find genes that share domains with IL17B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL17B_HUMAN, Q9UHF5
    Function: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1

         Genatlas biochemistry entry for IL17B:
    interleukin 17B,expressed in adult pancreas,small intestine stomach,not expressed in activated T cells,not binding
    to the IL17 receptor

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
         
    Find genes that share ontologies with IL17B           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Il17b (no phenotypes)

    Find genes that share phenotypes with IL17B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Il17btm1Lex for IL17B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL17B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL17B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL17B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL17B

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IL17B

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: IL17B (NM_014443)
    Sino Biological Human cDNA Clone for IL17B
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL17B

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL17B_HUMAN, Q9UHF5: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with IL17B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL17B About    
    See pathways by source

    SuperPathContained pathways About
    1IL-17 Family Signaling Pathways
    IL-17 Family Signaling Pathways0.51
    IL17 signaling pathway0.51
    2PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43


    Find genes that share SuperPaths with IL17B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL17B
        IL-17 Family Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL17B (see all 24)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling

    1 BioSystems Pathway for IL17B
        IL17 signaling pathway



    1 Kegg Pathway  (Kegg details for IL17B):
        Cytokine-cytokine receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL17B: 
              Th17 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Common Cytokines in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IL17B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for IL17B (Q9UHF52, 3 ENSP000002617964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENO2P091042, 3MINT-63443 I2D: score=5 
    IL17RBQ9NRM63, ENSP000002881674I2D: score=3 STRING: ENSP00000288167
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    --Q6FHV63I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0006955immune response TAS10639155
    GO:0007267cell-cell signaling TAS10639155
    GO:1900017positive regulation of cytokine production involved in inflammatory response IEA--

    Find genes that share ontologies with IL17B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL17B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL17B gene: 
    NM_014443.2  

    Unigene Cluster for IL17B:

    Interleukin 17B
    Hs.156979  [show with all ESTs]
    Unigene Representative Sequence: NM_014443
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518814 ENST00000261796(uc003lqo.3) ENST00000505432
    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IL17B
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    OriGene ORF clones in mouse, rat for IL17B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL17B (NM_014443)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL17B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL17B
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IL17B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL17B
      QuantiTect SYBR Green Assays in human, mouse, rat IL17B
      QuantiFast Probe-based Assays in human, mouse, rat IL17B

    Additional mRNA sequence: 

    AF110385.1 AF152098.1 AF184969.1 AF212311.1 AF218727.1 AY358931.1 BC113925.1 BC113946.1 
    CR457192.1 

    3 DOTS entries:

    DT.310662  DT.97834163  DT.91700292 

    Selected AceView cDNA sequences (see all 31):

    AF218727 AY358931 NM_014443 BU741486 BM682816 AF152098 BM719497 AI867949 
    BU753501 AA680405 CA413832 AF110385 AI375735 BQ574994 BM826445 AA443286 
    BM724859 CR457192 AA780147 BF476508 AA704834 AI370793 AF212311 AF184969 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL17B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGACCATCG
    IL17B Expression
    About this image


    IL17B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Long Bone
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
    IL17B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL17B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.156979

    UniProtKB/Swiss-Prot: IL17B_HUMAN, Q9UHF5
    Tissue specificity: Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced
    expression in prostate, colon mucosal lining, and ovary

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL17B: 
              Th17 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Common Cytokines in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL17B gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il17b1 , 5 interleukin 17B1, 5 84.63(n)1
    88.33(a)1
      18 (34.67 cM)5
    560691  NM_019508.11  NP_062381.11 
     616879355 
    chicken
    (Gallus gallus)
    Aves IL17B1 interleukin 17B 67.43(n)
    56.32(a)
      427620  XM_004944837.1  XP_004944894.1 
    lizard
    (Anolis carolinensis)
    Reptilia IL17B6
    interleukin 17B
    47(a)
    1 ↔ 1
    2(122749366-122754558)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia il17b1 interleukin 17B 60.71(n)
    57.62(a)
      448327  NM_001006698.1  NP_001006699.1 


    ENSEMBL Gene Tree for IL17B (if available)
    TreeFam Gene Tree for IL17B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL17B gene
    IL17D2  

    Find genes that share paralogs with IL17B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL17B (see all 173)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs771028761,2
    F--148753339(+) TTAAAG/AGAAAC 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs22274701,2
    C,F--148753353(-) cacccG/AgccCA 1 -- ds50014Minor allele frequency- A:0.02NS WA 256
    rs1869108721,2
    --148753472(+) CCCCAC/TATCTA 1 -- ds50010--------
    rs3752081,2
    C,F--148753511(-) GTGTGT/CGCCAC 1 -- ds500111Minor allele frequency- C:0.13EA NA NS 440
    rs22274631,2
    C,F--148753650(-) CATGTGT/-TTCCT 1 -- ds50013Minor allele frequency- -:0.01NS 142
    rs1912785971,2
    C--148753669(+) TAGGTA/GGTAGA 1 -- ds50010--------
    rs22274621,2
    C,F--148753766(-) CCTGGG/AAGGTA 1 -- ds50014Minor allele frequency- A:0.01NS NA 140
    rs1154984741,2
    C,F--148753803(+) ACTTCG/AAAGCC 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1389915631,2
    C--148753999(+) CTGTGC/TGGGGC 2 H R mis12Minor allele frequency- T:0.00NA EU 5043
    rs1499082631,2
    C,F--148754005(+) GGGGCG/AGTGGC 2 /P /L mis11Minor allele frequency- A:0.00NA 4132

    HapMap Linkage Disequilibrium report for IL17B (148750887 - 148783765 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL17B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv883023CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL17B
    DNA2.0 Custom Variant and Variant Library Synthesis for IL17B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604627    OMIM disorders: --


    Find genes that share disorders with IL17B           About GenesLikeMe

    7 Novoseek inferred disease relationships for IL17B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    psoriasis 58.8 16 17911452 (5), 14712309 (1), 16778121 (1), 18758357 (1)
    leiomyoma 50.9 1 12761473 (1)
    rheumatoid arthritis 27.4 7 18061474 (4), 18758357 (1)
    inflammation 25 2 16947773 (1), 11470428 (1)
    necrosis 22.3 6 16709143 (1), 10639155 (1), 18061474 (1), 18758357 (1)
    arthritis 12.3 4 16947773 (3)
    tumors 7.06 7 16908179 (1), 16709143 (1), 10639155 (1), 16511554 (1) (see all 5)

    Genetic Association Database (GAD): IL17B
    Human Genome Epidemiology (HuGE) Navigator: IL17B (3 documents)

    Export disorders for IL17B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL17B gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with IL17B)
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    1. Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. (PubMed id 10639155)1, 2, 3, 9 Li H.... Wood W.I. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    2. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. (PubMed id 19845895)1, 4 Koskinen L.L....Saavalainen P. (Tissue Antigens 2009)
    3. Chromosome 5q candidate genes in coeliac disease: genetic variation at IL4, IL5, IL9, IL13, IL17B and NR3C1. (PubMed id 15713213)1, 4 Ryan A.W....McManus R. (Tissue Antigens 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. (PubMed id 10749887)1, 2 Shi Y.... Ebner R. (J. Biol. Chem. 2000)
    7. Neutrophils produce interleukin-17B in rheumatoid synovial tissue. (PubMed id 24056520)1 Kouri V.P....Mandelin J. (Rheumatology (Oxford) 2014)
    8. Correlations between concentrations of interleukin (IL)-17A, IL-17B and IL-17F, and endothelial cells and proangiogenic cytokines in systemic lupus erythematosus patients. (PubMed id 23661335)1 Robak E....Sysa-Jedrzejowska A. (Eur. Cytokine Netw. 2013)
    9. [Eukaryotic expression and biological activity of recombinant human IL-17B protein]. (PubMed id 22394632)1 Liu G.Q....Zhang X.G. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2012)
    10. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (J. Virol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27190 HGNC: 5982 AceView: IL17B Ensembl:ENSG00000127743 euGenes: HUgn27190
    ECgene: IL17B Kegg: 27190 H-InvDB: IL17B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL17B Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_17
    SeattleSNPshttp://pga.gs.washington.edu/data/il17b/

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL17B gene:
    Search GeneIP for patents involving IL17B

    GeneCards and IP:
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