Aliases for IL17A Gene
External Ids for IL17A Gene
Previous HGNC Symbols for IL17A Gene
Previous GeneCards Identifiers for IL17A Gene
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL17A Gene
IL17A (Interleukin 17A) is a Protein Coding gene. Diseases associated with IL17A include Arthritis and Aspiration Pneumonia. Among its related pathways are Akt Signaling and Cytokine production by Th17 cells in CF (Mouse model). GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL17F.
UniProtKB/Swiss-Prot for IL17A Gene
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).