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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL17A Gene

protein-coding GIFtS: 60
GCID: GC06P052051

interleukin 17A

(Previous name: interleukin 17 (cytotoxic T-lymphocyte-associated serine...)
(Previous symbols: CTLA8, IL17)

Explore 190 diseases affiliated with
IL17A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin 17A¹ ²		Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)¹ ²
CTLA8¹ ² ³ ⁵		Cytotoxic T-Lymphocyte-Associated Antigen 8² ³
IL17¹ ² ³ ⁵		CTLA-8² ³
IL-17¹ ² ³		Cytotoxic T-Lymphocyte-Associated Protein 8²
IL-17A¹ ² ³		Interleukin-17A¹

External Ids:	HGNC: 5981¹	Entrez Gene: 3605²	Ensembl: ENSG00000112115⁷	OMIM: 603149⁵	UniProtKB: Q16552³

Export aliases for IL17A gene to outside databases

Previous GC identifers: GC06P052160 GC06P051882

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL17A:

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates

the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6

and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this

cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and

multiple sclerosis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IL17_HUMAN, Q16552

Function: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression

of ICAM1/intracellular adhesion molecule 1 in fibroblasts

Gene Wiki entry for IL17A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL17A gene promoter:
STAT5B STAT1 AP-1 ATF-2 STAT5A CUTL1 C/EBPalpha STAT3 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL17A promoter sequence

Search SABiosciences Chromatin IP Primers for IL17A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL17A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12 Ensembl cytogenetic band: 6p12.2 HGNC cytogenetic band: 6p12

IL17A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL17A gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P052051: view genomic region (about GC identifiers)

Start:	52,051,185 bp from pter	End:	52,055,436 bp from pter
Size:	4,252 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL17_HUMAN, Q16552 (See protein sequence)

Recommended Name: Interleukin-17A precursor

Size: 155 amino acids; 17504 Da

Subunit: Homodimer

Subcellular location: Secreted

1 PDB 3D structure from and Proteopedia for IL17A:

2VXS (3D)

Secondary accessions: Q5T2P0

Explore the universe of human proteins at neXtProt for IL17A: NX_Q16552

Post-translational modifications:

Found both in glycosylated and nonglycosylated forms¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q16552

IL17A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002181.1

ENSEMBL proteins:

ENSP00000344192

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for IL17A (IL-17/IL-17A)
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	OriGene Purified Protein: IL17A OriGene Protein Over-expression Lysate: IL17A OriGene Custom Protein Services for IL17A
	GenScript Purified and Recombinant Proteins for IL17A
	Novus Biologicals IL17A Proteins Novus Biologicals IL17A Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IL17A
	Uscn Proteins for IL17A

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--
GO:0009897	external side of plasma membrane	IEA	--

IL17A for ontologies About GeneDecksing

IL17A Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IL17A
	R&D Systems Antibodies for IL17A (IL-17/IL-17A)
	OriGene Antibodies (see all 5): IL17A OriGene Custom Antibody Services for IL17A
	GenScript Custom Superior Antibodies Services for IL17A
	Novus Biologicals IL17A Antibodies
	Search for Antibodies for IL17A at Abcam
	Uscn Antibodies for IL17A
	ThermoFisher Antibodies for IL17A

Assay Products for IL17A:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Flow Cytometry Kits for IL17A (IL-17/IL-17A) (see all)
	GenScript Custom Assay Services for IL17A
	Enzo Life Sciences assays for IL17A
	Uscn ELISAs and CLIAs for IL17A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL17A for domains About GeneDecksing

2 InterPro domains/families:

IPR020440 Interleukin-17_chordata

IPR010345 Interleukin-17

Graphical View of Domain Structure for InterPro Entry Q16552

ProtoNet protein and cluster: Q16552

1 Blocks protein family: IPB010345 Interleukin-17

UniProtKB/Swiss-Prot: IL17_HUMAN, Q16552

Similarity: Belongs to the IL-17 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IL17_HUMAN, Q16552

Function: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression

of ICAM1/intracellular adhesion molecule 1 in fibroblasts

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL17A
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate IL17A (see all 13):
		hsa-miR-3163 hsa-miR-875-3p hsa-miR-1266 hsa-miR-19b-2* hsa-miR-101* hsa-miR-606 hsa-miR-888 hsa-miR-3157-5p

		SwitchGear 3'UTR luciferase reporter plasmid: IL17A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL17A (see all 7) OriGene shRNA RFP: IL17A OriGene siRNA: IL17A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL17A

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IL17A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL17A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL17A OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL17A (NM_002190)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL17A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL17A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL17A
		Search LifeMap BioReagents cell lines for IL17A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17A

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--

IL17A for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for IL17A:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Il17a/Il17f^{Il17a/tm1.1Impr} for IL17A
11 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Il17a):

cellular	craniofacial	digestive/alimentary	hematopoietic system	homeostasis/metabolism
immune system	mortality/aging	no phenotypic analysis	renal/urinary system	respiratory system
skeleton

IL17A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Mucin expression in CF via IL-6, IL-17 signaling pathways

	Mucin expression in CF via IL-6, IL-17 signaling pathways	1.00			Cytokine production by Th17 cells in CF (Mouse model)	0.37
	Cytokine production by Th17 cells in CF	0.45

Development_PDGF signaling via STATs and NF-kB

	Immune response_IL-23 signaling pathway	0.44			IL23-mediated signaling events	0.15
	Immune response IL-23 signaling pathway	0.41

Th17 Differentiation

Th17 Differentiation

1.00

IL27-mediated signaling events

IL27-mediated signaling events

1.00

Rheumatoid arthritis

Rheumatoid arthritis

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for IL17A

Immune response IL-23 signaling pathway

1 R&D Systems Pathway for IL17A

Th17 Differentiation

4 GeneGo (Thomson Reuters) Pathways for IL17A

	Cytokine production by Th17 cells in CF (Mouse model)
	Cytokine production by Th17 cells in CF
	Mucin expression in CF via IL-6, IL-17 signaling pathways
	Immune response IL-23 signaling pathway

3 BioSystems Pathways for IL17A

	TCR Signaling Pathway
	IL27-mediated signaling events
	IL23-mediated signaling events

2 Kegg Pathways (Kegg details for IL17A):

	Cytokine-cytokine receptor interaction
	Rheumatoid arthritis

IL17A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL17A

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/18 Interacting proteins for IL17A (Q16552³ ENSP00000344192⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL17RA	Q96F46³, ENSP00000320936⁴	I2D: score=2 STRING: ENSP00000320936
STAT3	P40763³, ENSP00000264657⁴	I2D: score=1 STRING: ENSP00000264657
TRAF3IP2	O43734³, ENSP00000345984⁴	I2D: score=1 STRING: ENSP00000345984
IL17RC	Q8NAC3³, ENSP00000295981⁴	I2D: score=1 STRING: ENSP00000295981
IL17F	Q96PD4³	I2D: score=1

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006486	protein glycosylation	TAS	7499828
GO:0006915	apoptotic process	TAS	7499828
GO:0006954	inflammatory response	IEA	--
GO:0006955	immune response	TAS	7499828
GO:0007267	cell-cell signaling	TAS	7499828

IL17A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL17A for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL17A
10/45 Novoseek chemical compound relationships for IL17A gene (see all 45) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	69.7	54	12165487 (6), 19927541 (5), 12372947 (2), 9646176 (1) (see all 39)
groalpha	47.8	6	11067941 (3), 16542136 (1), 19819721 (1)
sb 203580	45.3	13	15034939 (2), 15982617 (1), 12823853 (1), 18941244 (1) (see all 7)
pge2	42.1	68	11592370 (4), 11327240 (4), 18698005 (3), 10328864 (2) (see all 22)
vegf	41.3	75	15860217 (5), 16163444 (4), 17690908 (4), 20099977 (4) (see all 27)
ionomycin	38.7	14	17425422 (3), 10679127 (3), 10328864 (2), 20045653 (2) (see all 7)
infliximab	36.8	13	19728295 (3), 16680388 (3), 11950256 (1), 18092129 (1) (see all 6)
pd 98,059	36.7	3	10833473 (1), 11777983 (1), 17652082 (1)
etanercept	32.3	7	17619881 (2), 18763027 (2), 18466711 (1), 18039949 (1) (see all 9)
curdlan	28	1	20401539 (1)

Search CenterWatch for drugs/clinical trials and news about IL17A / IL17

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL17A gene:

NM_002190.2

Unigene Cluster for IL17A:

Interleukin 17A

Hs.41724 [show with all ESTs]

Unigene Representative Sequence: U32659

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000340057(uc003pak.1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL17A
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate IL17A (see all 13):
		hsa-miR-3163 hsa-miR-875-3p hsa-miR-1266 hsa-miR-19b-2* hsa-miR-101* hsa-miR-606 hsa-miR-888 hsa-miR-3157-5p

		SwitchGear 3'UTR luciferase reporter plasmid: IL17A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL17A (see all 7) OriGene shRNA RFP: IL17A OriGene siRNA: IL17A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL17A

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL17A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL17A OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL17A (NM_002190)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL17A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL17A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL17A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL17A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL17A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL17A

Additional cDNA sequence:

BC066251.1 BC066252.1 BC066253.1 BC067503.1 BC067504.1 BC067505.1 HM535222.1 U32659.1

Z58820.1

1 DOTS entry:

DT.101977073

20 AceView cDNA sequences:

CD559442 CD559595 BC067505 BC067503 NM_002190 BC066252 BC066251 CD559598

CD559599 BC067504 U32659 CD559600 CD559596 Z58820 CK130280 BC066253

CD559597 CD559601 CD559443 CD559447

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL17A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCATTATTAA

About this image
See IL17A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL17A

SOURCE GeneReport for Unigene cluster: Hs.41724

UniProtKB/Swiss-Prot: IL17_HUMAN, Q16552

Tissue specificity: Restricted to activated memory T-cells

SABiosciences Expression via Pathway-Focused PCR Arrays including IL17A (see all 10):

Inflammatory Response & Autoimmunity in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Innate & Adaptive Immune Responses in human mouse rat

Th17 Response in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL17A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL17A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL17A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL17A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL17A gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	IL17F⁶ IL17F⁶	Uncharacterized protein	41(a) 39(a)	many ↔ many many ↔ many	3(110369631-110371729) 3(110361775-110363081)
lizard (Anolis carolinensis)	Reptilia	--	--	41(a)	1 → many	1(122877784-122879470)
zebrafish (Danio rerio)	Actinopterygii	il17a/f2⁶	interleukin 17a/f2	33(a)	1 → many	17(12593558-12596932)

ENSEMBL Gene Tree for IL17A (if available)
TreeFam Gene Tree for IL17A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IL17A gene

IL17D² IL17F² IL17B² IL17C²

1 SIMAP similar gene for IL17A using alignment to 2 protein entries: IL17_HUMAN (see all proteins):

IL17F

IL17A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs115141668^1,2		--	52049224(+)	`GGTAAG/ACTTTG`	1	--	us2k¹		1		WA	118
rs188489621^1,2		--	52049291(+)	`GGGGGC/TAAGGC`	1	--	us2k¹		0	--	--	--	--
rs116636466^1,2	F,	--	52049489(+)	`GGGTGA/GGAGTG`	1	--	us2k¹		1		WA	118
rs116732936^1,2	F,	--	52049518(+)	`GAAATT/CGGTGA`	1	--	us2k¹		1		NA	120
rs201080846^1,2	C	--	52049574(-)	`GCCCCC/TCCTCT`	1	--	us2k¹		0	--	--	--	--
rs193148407^1,2		--	52049597(+)	`TCTGAA/GTCTTG`	1	--	us2k¹		0	--	--	--	--
rs184942593^1,2		--	52049644(+)	`GACTAC/TGGAAA`	1	--	us2k¹		0	--	--	--	--
rs147511224^1,2		--	52049711(+)	`GATATC/GTACTA`	1	--	us2k¹		0	--	--	--	--
rs17882215^1,2	C,	--	52049806(+)	`ATTTGC/TAACAG`	1	--	us2k¹		3		NS NA	88
rs12195273^1,2	H,	--	52050019(+)	`CCTAGC/ATGAAA`	1	--	us2k¹		4		NS EA	420

HapMap Linkage Disequilibrium report for IL17A (52051185 - 52055436 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IL17A: --
Human Gene Mutation Database (HGMD): IL17A

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL17A

DNA2.0 Custom Variant and Variant Library Synthesis for IL17A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL17A for disorders           About GeneDecksing

OMIM gene information: 603149    OMIM disorders: --

20/190 diseases for IL17A (see all 190):    About MalaCards

rheumatoid arthritis vogt-koyanagi-harada disease multiple sclerosis psoriasis

arthritis hyper-ige syndrome transverse myelitis autoimmune polyendocrine syndrome type 1

subacute sclerosing panencephalitis langerhans-cell histiocytosis hypersensitivity reaction type ii disease autoimmune polyendocrine syndrome

graft versus host disease chronic mucocutaneous candidiasis non-small cell lung carcinoma bronchiolitis obliterans

paranasal sinus disease allergic contact dermatitis common variable immunodeficiency contact dermatitis

3 diseases from the University of Copenhagen DISEASES database for IL17A:

Arthritis Hypersensitivity reaction type II disease Multiple sclerosis

10/94 Novoseek disease relationships for IL17A gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
autoimmune diseases	79.7	66	18004573 (2), 19234216 (2), 16815032 (2), 16200068 (1) (see all 49)
rheumatoid arthritis	78.5	132	18033994 (5), 10679127 (5), 19798029 (3), 14984588 (3) (see all 80)
autoimmunity	78.4	47	17942669 (1), 19109162 (1), 19101114 (1), 19444307 (1) (see all 30)
inflammation	78	205	19783683 (3), 15901616 (3), 18941201 (3), 12678335 (2) (see all 99)
encephalomyelitis	70.3	19	19055697 (2), 18156204 (2), 16200068 (1), 18424707 (1) (see all 14)
arthritis	69.4	103	12721360 (5), 15972960 (4), 11441109 (4), 18039580 (4) (see all 50)
necrosis	67.7	194	12661990 (2), 15845864 (2), 16143885 (2), 15229940 (2) (see all 99)
psoriasis	66.6	53	15315354 (3), 18981165 (3), 18763027 (3), 19330474 (2) (see all 23)
bone destruction	65	15	11299057 (2), 19252243 (1), 18033994 (1), 11407688 (1) (see all 9)
multiple sclerosis	62.4	28	18156204 (2), 18164424 (1), 18063700 (1), 18417225 (1) (see all 20)

Human Genome Epidemiology (HuGE) Navigator: IL17A (48 documents)

Export disorders for IL17A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for IL17A gene, integrated from 9 sources (see all 1379):
(articles sorted by number of sources associating them with IL17A)

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Structure of IL-17A in complex with a potent, fully h uman neutralizing antibody. (PubMed id 19835883)^{1, 2, 9} Gerhardt S....Russell C. (2009)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. (PubMed id 8676080)^{1, 2} Fossiez F....Lebecque S. (1996)
Human IL-17: a novel cytokine derived from T cells. (PubMed id 7499828)^{1, 2} Yao Z.... Armitage R.J. (1995)
CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. (PubMed id 8390535)^{1, 3} Rouvier E....Golstein P. (1993)
IL-17 expression by breast-cancer-associated macrophages: IL-17 promotes invasiveness of breast cancer cell lines. (PubMed id 19014637)^{1, 9} Zhu X....Jackson A.M. (2008)
[Expression of interleukin-17 in hepatitis B related liver fibrosis.] (PubMed id 19174010)^{1, 9} Xu Y....Chen S.J. (2009)
The potential role of interleukin-17 in the immunopathology of periodontal disease. (PubMed id 15811054)^{1, 9} Takahashi K....Kitetsu S. (2005)
Monocyte derived interleukin (IL)-23 is an important determinant of synovial IL-17A expression in rheumatoid arthritis. (PubMed id 19797506)^{1, 9} Stamp L.K....Hessian P.A. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3605	HGNC: 5981	AceView: IL17	Ensembl:ENSG00000112115	euGenes: HUgn3605
ECgene: IL17A	Kegg: 3605	H-InvDB: IL17A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IL17A	Pharmacogenomics, SNPs, Pathways
R&D Systems' cytokine mini-reviews: IL-17	http://www.rndsystems.com/molecule_detail.aspx?m=1674
Wikipedia	http://en.wikipedia.org/wiki/Interleukin_17
SeattleSNPs	http://pga.gs.washington.edu/data/il17/

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interleukin 17A

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