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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL17A Gene

protein-coding   GIFtS: 62
GCID: GC06P052051

Interleukin 17A

(Previous name: interleukin 17 (cytotoxic T-lymphocyte-associated serine...)
(Previous symbols: CTLA8, IL17)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 17A1 2     Cytotoxic T-Lymphocyte-Associated Antigen 82 3
CTLA81 2 3 5     CTLA-82 3
IL171 2 3 5     IL-172 3
Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)1 2     IL-17A2 3
Cytotoxic T-Lymphocyte-Associated Protein 81 2     interleukin-17A2

External Ids:    HGNC: 59811   Entrez Gene: 36052   Ensembl: ENSG000001121157   OMIM: 6031495   UniProtKB: Q165523   

Export aliases for IL17A gene to outside databases

Previous GC identifers: GC06P052160 GC06P051882


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL17A Gene:
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine
regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the
expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).
High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid
arthritis, psoriasis and multiple sclerosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL17A Gene: 
IL17A (interleukin 17A) is a protein-coding gene. Diseases associated with IL17A include paranasal sinus disease, and autosomal dominant hyper ige syndrome, and among its related super-pathways are Mucin expression in CF via IL-6, IL-17 signaling pathways and Immune response IL-23 signaling pathway. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL17F.

UniProtKB/Swiss-Prot: IL17_HUMAN, Q16552
Function: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface
expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts

Gene Wiki entry for IL17A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL17A gene promoter:
         STAT5B   STAT1   AP-1   ATF-2   STAT5A   CUTL1   C/EBPalpha   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL17A promoter sequence
   Search SABiosciences Chromatin IP Primers for IL17A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL17A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12   Ensembl cytogenetic band:  6p12.2   HGNC cytogenetic band: 6p12

IL17A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL17A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P052051:  view genomic region     (about GC identifiers)

Start:
52,051,185 bp from pter      End:
52,055,436 bp from pter
Size:
4,252 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL17_HUMAN, Q16552 (See protein sequence)
Recommended Name: Interleukin-17A precursor  
Size: 155 amino acids; 17504 Da
Subunit: Homodimer
Subcellular location: Secreted
3 PDB 3D structures from and Proteopedia for IL17A:
2VXS (3D)        4HR9 (3D)        4HSA (3D)    
Secondary accessions: Q5T2P0

Explore the universe of human proteins at neXtProt for IL17A: NX_Q16552

Explore proteomics data for IL17A at MOPED 

Post-translational modifications:

  • UniProtKB: Found both in glycosylated and nonglycosylated forms
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16552

  • IL17A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL17A Protein Expression
    REFSEQ proteins: NP_002181.1  
    ENSEMBL proteins: 
     ENSP00000344192  

    Human Recombinant Protein Products for IL17A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL17A (IL-17/IL-17A)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IL17A
    OriGene Protein Over-expression Lysate for IL17A
    OriGene MassSpec for IL17A 
    OriGene Custom Protein Services for IL17A
    GenScript Purified and Recombinant Proteins for IL17A
    Novus Biologicals IL17A Proteins
    Novus Biologicals IL17A Lysate
    Sino Biological Recombinant Protein for IL17A
    Sino Biological Cell Lysate for IL17A 
    ProSpec Recombinant Protein for IL17A
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--
    GO:0009897external side of plasma membrane IEA--

    IL17A for ontologies           About GeneDecksing



    IL17A Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL17A
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    Abcam antibodies for IL17A
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    LSBio Antibodies in human, mouse, rat for IL17A 

    Assay Products for IL17A: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for IL17A
    Enzo Life Sciences assays for IL17A
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IL: Interleukins and interleukin receptors

    2 InterPro protein domains:
     IPR010345 Interleukin-17
     IPR020440 Interleukin-17_chordata

    Graphical View of Domain Structure for InterPro Entry Q16552

    ProtoNet protein and cluster: Q16552

    1 Blocks protein domain: IPB010345 Interleukin-17

    UniProtKB/Swiss-Prot: IL17_HUMAN, Q16552
    Similarity: Belongs to the IL-17 family


    IL17A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL17_HUMAN, Q16552
    Function: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface
    expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
         
    IL17A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IL17A:
     Increased gamma-H2AX phosphory 

         11 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Il17a):
     cellular  craniofacial  digestive/alimentary  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  no phenotypic analysis  renal/urinary system  respiratory system 
     skeleton 

    IL17A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Il17a/Il17fIl17a/tm1.1Impr for IL17A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL17A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL17A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL17A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL17A 

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate IL17A (see all 13):
    hsa-miR-3163 hsa-miR-875-3p hsa-miR-1266 hsa-miR-19b-2* hsa-miR-101* hsa-miR-606 hsa-miR-888 hsa-miR-3157-5p
    SwitchGear 3'UTR luciferase reporter plasmidIL17A 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for IL17A
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of IL17A

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL17A
    Sirion Biotech Customized lentivirus for stable overexpression of IL17A 
                         Customized lentivirus expression plasmids for stable overexpression of IL17A 

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    Search LifeMap BioReagents cell lines for IL17A
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL17A About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Mucin expression in CF via IL-6, IL-17 signaling pathways
    Mucin expression in CF via IL-6, IL-17 signaling pathways0.48
    IL-17 Signaling0.48
    2Development PDGF signaling via STATs and NF-kB
    Immune response IL-23 signaling pathway0.91
    IL23-mediated signaling events0.38
    3Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF0.72
    Cytokine production by Th17 cells in CF (Mouse model)0.72
    4Th17 Differentiation
    Th17 Differentiation0.47
    5PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for IL17A
        Immune response IL-23 signaling pathway

    2 R&D Systems Pathways for IL17A
        IL-17 Signaling
    Th17 Differentiation


    4 GeneGo (Thomson Reuters) Pathways for IL17A
        Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF
    Mucin expression in CF via IL-6, IL-17 signaling pathways
    Immune response IL-23 signaling pathway

    3 BioSystems Pathways for IL17A
        TCR Signaling Pathway
    IL23-mediated signaling events
    IL27-mediated signaling events



    3         Kegg Pathways  (Kegg details for IL17A):
        Cytokine-cytokine receptor interaction
    Inflammatory bowel disease (IBD)
    Rheumatoid arthritis


    IL17A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL17A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/18 Interacting proteins for IL17A (Q165523 ENSP000003441924) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL17RAQ96F463, ENSP000003209364I2D: score=2 STRING: ENSP00000320936
    STAT3P407633, ENSP000002646574I2D: score=1 STRING: ENSP00000264657
    TRAF3IP2O437343, ENSP000003459844I2D: score=1 STRING: ENSP00000345984
    IL17RCQ8NAC33, ENSP000002959814I2D: score=1 STRING: ENSP00000295981
    IL17FQ96PD43I2D: score=1 
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation TAS7499828
    GO:0006915apoptotic process TAS7499828
    GO:0006954inflammatory response IEA--
    GO:0006955immune response TAS7499828
    GO:0007267cell-cell signaling TAS7499828

    IL17A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL17A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL17A (IL17)

    10/45 Novoseek inferred chemical compound relationships for IL17A gene (see all 45)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 69.7 54 12165487 (6), 19927541 (5), 12372947 (2), 9646176 (1) (see all 39)
    groalpha 47.8 6 11067941 (3), 16542136 (1), 19819721 (1)
    sb 203580 45.3 13 15034939 (2), 15982617 (1), 12823853 (1), 18941244 (1) (see all 7)
    pge2 42.1 68 11592370 (4), 11327240 (4), 18698005 (3), 10328864 (2) (see all 22)
    vegf 41.3 75 15860217 (5), 16163444 (4), 17690908 (4), 20099977 (4) (see all 27)
    ionomycin 38.7 14 17425422 (3), 10679127 (3), 10328864 (2), 20045653 (2) (see all 7)
    infliximab 36.8 13 19728295 (3), 16680388 (3), 11950256 (1), 18092129 (1) (see all 6)
    pd 98,059 36.7 3 10833473 (1), 11777983 (1), 17652082 (1)
    etanercept 32.3 7 17619881 (2), 18763027 (2), 18466711 (1), 18039949 (1) (see all 9)
    curdlan 28 1 20401539 (1)

    Search CenterWatch for drugs/clinical trials and news about IL17A / IL17

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL17A gene: 
    NM_002190.2  

    Unigene Cluster for IL17A:

    Interleukin 17A
    Hs.41724  [show with all ESTs]
    Unigene Representative Sequence: U32659
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000340057(uc003pak.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate IL17A (see all 13):
    hsa-miR-3163 hsa-miR-875-3p hsa-miR-1266 hsa-miR-19b-2* hsa-miR-101* hsa-miR-606 hsa-miR-888 hsa-miR-3157-5p
    SwitchGear 3'UTR luciferase reporter plasmidIL17A 3' UTR sequence
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL17A
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL17A

    Additional mRNA sequence: 

    BC066251.1 BC066252.1 BC066253.1 BC067503.1 BC067504.1 BC067505.1 HM535222.1 U32659.1 
    Z58820.1 

    1 DOTS entry:

    DT.101977073 

    20 AceView cDNA sequences:

    CD559442 CD559595 BC067503 NM_002190 BC066252 BC067505 BC066253 CD559599 
    CK130280 CD559600 U32659 CD559598 BC066251 BC067504 CD559596 Z58820 
    CD559601 CD559597 CD559443 CD559447 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL17A expression in normal human tissues (normalized intensities)      IL17A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATTATTAA
    IL17A Expression
    About this image


    IL17A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Adipose (Muscoskeletal System)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Bone (Muscoskeletal System)
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells

    See IL17A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL17A

    SOURCE GeneReport for Unigene cluster: Hs.41724

    UniProtKB/Swiss-Prot: IL17_HUMAN, Q16552
    Tissue specificity: Restricted to activated memory T-cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL17A (see all 10): 
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat
              Th17 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL17A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL17A gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il17a1 , 5 interleukin 17A1, 5 75.91(n)1
    63.23(a)1
      1 (6.45 cM)5
    161711  NM_010552.31  NP_034682.11 
     207309055 
    chicken
    (Gallus gallus)
    Aves IL17F6
    IL17F6
    Uncharacterized protein
    40(a)
    38(a)
    possible ortholog
    possible ortholog
    3(107193900-107196824)
    3(107185996-107187311)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    33(a)
    possible ortholog
    1(122877292-122881562)
    zebrafish
    (Danio rerio)
    Actinopterygii il17a/f36
    il17a/f16
    interleukin 17a/f1
    28(a)
    24(a)
    many ↔ many
    many ↔ many
    20(34816796-34818723)
    17(12573842-12576188)


    ENSEMBL Gene Tree for IL17A (if available)
    TreeFam Gene Tree for IL17A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL17A gene
    IL17F2  IL17C2  
    1 SIMAP similar gene for IL17A using alignment to 2 protein entries:     IL17_HUMAN (see all proteins):
    IL17F

    IL17A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/144 SNPs in IL17A are shown (see all 144)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1151416681,2
    C,F--51961818(+) GGTAAG/ACTTTG 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1884896211,2
    --51961885(+) GGGGGC/TAAGGC 1 -- us2k10--------
    rs1166364661,2
    F--51962083(+) GGGTGA/GGAGTG 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1167329361,2
    C,F--51962112(+) GAAATT/CGGTGA 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs2010808461,2
    C--51962168(-) GCCCCC/TCCTCT 1 -- us2k10--------
    rs1931484071,2
    --51962191(+) TCTGAA/GTCTTG 1 -- us2k10--------
    rs1849425931,2
    --51962238(+) GACTAC/TGGAAA 1 -- us2k10--------
    rs1475112241,2
    --51962305(+) GATATC/GTACTA 1 -- us2k10--------
    rs178822151,2
    C,F--51962400(+) ATTTGC/TAACAG 1 -- us2k13Minor allele frequency- T:0.01NS NA 88
    rs121952731,2
    C,F,H--51962613(+) CCTAGC/ATGAAA 1 -- us2k14Minor allele frequency- A:0.00NS EA 420

    HapMap Linkage Disequilibrium report for IL17A (52051185 - 52055436 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IL17A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv522645CNV Gain19592680
    nsv830662CNV Gain17160897


    Human Gene Mutation Database (HGMD): IL17A
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IL17A
    DNA2.0 Custom Variant and Variant Library Synthesis for IL17A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603149    OMIM disorders: --

    20/194 diseases for IL17A (see all 194):    About MalaCards
    paranasal sinus disease    autosomal dominant hyper ige syndrome    transverse myelitis    autoimmune enteropathy
    myelitis    psoriasis    multiple sclerosis    bronchiolitis obliterans
    autoimmune polyendocrine syndrome type 1    autoimmune polyendocrine syndrome    bronchiolitis    stromal keratitis
    toxoplasmosis    spondylitis    radiculopathy    trachoma
    chronic mucocutaneous candidiasis    ileus    invasive aspergillosis    keratitis

    3 diseases from the University of Copenhagen DISEASES database for IL17A:
    Arthritis     Hypersensitivity reaction type II disease     Multiple sclerosis

    IL17A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/94 Novoseek inferred disease relationships for IL17A gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 79.7 66 18004573 (2), 19234216 (2), 16815032 (2), 16200068 (1) (see all 49)
    rheumatoid arthritis 78.5 132 18033994 (5), 10679127 (5), 19798029 (3), 14984588 (3) (see all 80)
    autoimmunity 78.4 47 17942669 (1), 19109162 (1), 19101114 (1), 19444307 (1) (see all 30)
    inflammation 78 205 19783683 (3), 15901616 (3), 18941201 (3), 12678335 (2) (see all 99)
    encephalomyelitis 70.3 19 19055697 (2), 18156204 (2), 16200068 (1), 18424707 (1) (see all 14)
    arthritis 69.4 103 12721360 (5), 15972960 (4), 11441109 (4), 18039580 (4) (see all 50)
    necrosis 67.7 194 12661990 (2), 15845864 (2), 16143885 (2), 15229940 (2) (see all 99)
    psoriasis 66.6 53 15315354 (3), 18981165 (3), 18763027 (3), 19330474 (2) (see all 23)
    bone destruction 65 15 11299057 (2), 19252243 (1), 18033994 (1), 11407688 (1) (see all 9)
    multiple sclerosis 62.4 28 18156204 (2), 18164424 (1), 18063700 (1), 18417225 (1) (see all 20)

    Genetic Association Database (GAD): IL17A
    Human Genome Epidemiology (HuGE) Navigator: IL17A (48 documents)

    Export disorders for IL17A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL17A gene, integrated from 9 sources (see all 1444):
    (articles sorted by number of sources associating them with IL17A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of IL-17A in complex with a potent, fully h uman neutralizing antibody. (PubMed id 19835883)1, 2, 9 Gerhardt S....Russell C. (2009)
    2. Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis. (PubMed id 17876645)1, 4, 9 Furuya T....Kotake S. (2007)
    3. Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis. (PubMed id 19414056)1, 4, 9 Shibata T....Arisawa T. (2009)
    4. Interleukin-17A gene variants and risk of coronary ar tery disease: A large angiography-based study. (PubMed id 21062626)1, 4 Zhang X....Han Y. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Association between polymorphisms in interleukin-17A and interleukin-17F genes and risks of gastric cancer. (PubMed id 19904747)1, 4 Wu X....Hu P. (2010)
    7. The polymorphism of IL-17 G-152A was associated with childhood asthma and bacterial colonization of the hypopharynx in bronchiolitis . (PubMed id 20437253)1, 4 Chen J....Liu E. (2010)
    8. Polymorphisms in cytokine genes and serum cytokine le vels among New Mexican women with and without breast cancer. (PubMed id 20418110)1, 4 Erdei E....Berwick M. (2010)
    9. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    10. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3605 HGNC: 5981 AceView: IL17 Ensembl:ENSG00000112115 euGenes: HUgn3605
    ECgene: IL17A Kegg: 3605 H-InvDB: IL17A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL17A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL17A Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine mini-reviews: IL-17http://www.rndsystems.com/molecule_detail.aspx?m=1674
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_17
    SeattleSNPshttp://pga.gs.washington.edu/data/il17/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL17A gene:
    Search GeneIP for patents involving IL17A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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