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Aliases for IL17A Gene

Aliases for IL17A Gene

  • Interleukin 17A 2 3
  • Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) 2 3
  • Cytotoxic T-Lymphocyte-Associated Protein 8 2 3
  • Cytotoxic T-Lymphocyte-Associated Antigen 8 3 4
  • CTLA-8 3 4
  • IL-17A 3 4
  • CTLA8 3 4
  • IL-17 3 4
  • IL17 3 4

External Ids for IL17A Gene

Previous HGNC Symbols for IL17A Gene

  • CTLA8
  • IL17

Previous GeneCards Identifiers for IL17A Gene

  • GC06P052160
  • GC06P052051
  • GC06P051882

Summaries for IL17A Gene

Entrez Gene Summary for IL17A Gene

  • The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL17A Gene

IL17A (Interleukin 17A) is a Protein Coding gene. Diseases associated with IL17A include neurosyphilis and aspiration pneumonia. Among its related pathways are TGF-Beta Pathway and Akt Signaling. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL17C.

UniProtKB/Swiss-Prot for IL17A Gene

  • Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts

Gene Wiki entry for IL17A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17A Gene

Genomics for IL17A Gene

Regulatory Elements for IL17A Gene

Genomic Location for IL17A Gene

Chromosome:
6
Start:
52,186,387 bp from pter
End:
52,190,638 bp from pter
Size:
4,252 bases
Orientation:
Plus strand

Genomic View for IL17A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL17A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17A Gene

Proteins for IL17A Gene

  • Protein details for IL17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16552-IL17_HUMAN
    Recommended name:
    Interleukin-17A
    Protein Accession:
    Q16552
    Secondary Accessions:
    • Q5T2P0

    Protein attributes for IL17A Gene

    Size:
    155 amino acids
    Molecular mass:
    17504 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for IL17A Gene

neXtProt entry for IL17A Gene

Proteomics data for IL17A Gene at MOPED

Post-translational modifications for IL17A Gene

Other Protein References for IL17A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for IL17A Gene

Domains & Families for IL17A Gene

Gene Families for IL17A Gene

Protein Domains for IL17A Gene

Suggested Antigen Peptide Sequences for IL17A Gene

Graphical View of Domain Structure for InterPro Entry

Q16552

UniProtKB/Swiss-Prot:

IL17_HUMAN :
  • Belongs to the IL-17 family.
Family:
  • Belongs to the IL-17 family.
genes like me logo Genes that share domains with IL17A: view

Function for IL17A Gene

Molecular function for IL17A Gene

UniProtKB/Swiss-Prot Function:
Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts

Gene Ontology (GO) - Molecular Function for IL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005126 cytokine receptor binding IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with IL17A: view
genes like me logo Genes that share phenotypes with IL17A: view

Animal Models for IL17A Gene

MGI Knock Outs for IL17A:

Animal Model Products

miRNA for IL17A Gene

miRTarBase miRNAs that target IL17A

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL17A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL17A Gene

Localization for IL17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL17A Gene COMPARTMENTS Subcellular localization image for IL17A gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
plasma membrane 2
cytoskeleton 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for IL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IEA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with IL17A: view

Pathways & Interactions for IL17A Gene

genes like me logo Genes that share pathways with IL17A: view

PCR Array Products

SIGNOR curated interactions for IL17A Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for IL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation --
GO:0006915 apoptotic process TAS 7499828
GO:0006954 inflammatory response IBA --
GO:0006955 immune response TAS 7499828
GO:0007166 cell surface receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with IL17A: view

Drugs & Compounds for IL17A Gene

(23) Drugs for IL17A Gene - From: NovoSeek, ApexBio, DGIdb, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational Pharma Agonist 1806
Etanercept Approved, Investigational Pharma 0
Indomethacin Approved, Investigational Pharma Inhibition, Inhibitor Cox inhibitor 97
Infliximab Approved Pharma 327
methacholine Approved Pharma 0

(25) Additional Compounds for IL17A Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Actinomycin D
Creatinine
  • 1-Methylglycocyamidine
  • 1-Methylhydantoin-2-imide
  • 2-Amino-1-methyl-1,5-dihydroimidazol-4-one
  • 2-Amino-1-methylimidazolin-4-one
  • Creatine anhydride
60-27-5
Curdlan
Endotoxin
GROalpha
genes like me logo Genes that share compounds with IL17A: view

Transcripts for IL17A Gene

mRNA/cDNA for IL17A Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL17A Gene

Interleukin 17A:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL17A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL17A Gene

No ASD Table

Relevant External Links for IL17A Gene

GeneLoc Exon Structure for
IL17A
ECgene alternative splicing isoforms for
IL17A

Expression for IL17A Gene

mRNA expression in normal human tissues for IL17A Gene

mRNA differential expression in normal tissues according to GTEx for IL17A Gene

This gene is overexpressed in Minor Salivary Gland (x8.8), Esophagus - Mucosa (x8.2), Small Intestine - Terminal Ileum (x5.7), Vagina (x4.5), and Fallopian Tube (x4.3).

SOURCE GeneReport for Unigene cluster for IL17A Gene Hs.41724

mRNA Expression by UniProt/SwissProt for IL17A Gene

Q16552-IL17_HUMAN
Tissue specificity: Restricted to activated memory T-cells
genes like me logo Genes that share expression patterns with IL17A: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for IL17A Gene

Orthologs for IL17A Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL17A 35
  • 84.69 (n)
  • 76.3 (a)
IL17 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL17A 35
  • 86.67 (n)
  • 82.22 (a)
IL-17A 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il17a 35
  • 74.62 (n)
  • 61.29 (a)
Il17a 16
Il17a 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL17A 35
  • 99.78 (n)
  • 99.35 (a)
IL17A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il17a 35
  • 77.05 (n)
  • 61.59 (a)
oppossum
(Monodelphis domestica)
Mammalia IL17A 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL17A 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL17F 36
  • 40 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734167 35
  • 58.7 (n)
  • 51.33 (a)
zebrafish
(Danio rerio)
Actinopterygii il17a/f1 36
  • 27 (a)
ManyToMany
il17a/f3 36
  • 29 (a)
ManyToMany
Species with no ortholog for IL17A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL17A Gene

ENSEMBL:
Gene Tree for IL17A (if available)
TreeFam:
Gene Tree for IL17A (if available)

Paralogs for IL17A Gene

Paralogs for IL17A Gene

(1) SIMAP similar genes for IL17A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IL17A: view

Variants for IL17A Gene

Sequence variations from dbSNP and Humsavar for IL17A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1974226 -- 52,190,537(-) AGTTC(A/G)TTCTG utr-variant-3-prime
rs2275913 -- 52,186,235(+) AGAAG(A/G)AGAGA upstream-variant-2KB
rs3748067 -- 52,190,541(-) TTAAA(A/G)TTCGT utr-variant-3-prime
rs3804513 -- 52,188,399(+) ACTTC(A/T)TACAA intron-variant
rs3819024 -- 52,185,988(+) TGAGG(A/G)AAAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IL17A Gene

Variant ID Type Subtype PubMed ID
nsv830662 CNV Gain 17160897
nsv522645 CNV Gain 19592680

Variation tolerance for IL17A Gene

Residual Variation Intolerance Score: 65.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL17A Gene

HapMap Linkage Disequilibrium report
IL17A
Human Gene Mutation Database (HGMD)
IL17A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17A Gene

Disorders for IL17A Gene

MalaCards: The human disease database

(71) MalaCards diseases for IL17A Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
neurosyphilis
aspiration pneumonia
  • pneumonia aspiration
stromal keratitis
bronchiolitis obliterans
  • bronchiolitis fibrosa obliterans
allergic contact dermatitis
  • dermatitis allergic contact
- elite association
Search IL17A in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL17A

Genetic Association Database (GAD)
IL17A
Human Genome Epidemiology (HuGE) Navigator
IL17A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL17A
genes like me logo Genes that share disorders with IL17A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL17A Gene

Publications for IL17A Gene

  1. Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis. (PMID: 19807734) Wang Y. … Sumida T. (Clin. Exp. Immunol. 2010) 23 67
  2. A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour. (PMID: 19969371) Ito M. … Saito S. (J. Reprod. Immunol. 2010) 23 67
  3. CEL-2000: A therapeutic vaccine for rheumatoid arthritis arrests disease development and alters serum cytokine/chemokine patterns in the bovine collagen type II induced arthritis in the DBA mouse model. (PMID: 20074669) Zimmerman D.H. … Rosenthal K.S. (Int. Immunopharmacol. 2010) 23 67
  4. Interleukin-17 may be a valuable serum tumor marker in patients with colorectal carcinoma. (PMID: 20099977) Radosavljevic G. … Arsenijevic N. (Neoplasma 2010) 23 67
  5. IL-17 produced during Trypanosoma cruzi infection plays a central role in regulating parasite-induced myocarditis. (PMID: 20169058) da Matta Guedes P.M. … Silva J.S. (PLoS Negl Trop Dis 2010) 23 67

Products for IL17A Gene

  • Addgene plasmids for IL17A

Sources for IL17A Gene

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