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Aliases for IL17A Gene

Aliases for IL17A Gene

  • Interleukin 17A 2 3 5
  • Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) 2 3
  • Cytotoxic T-Lymphocyte-Associated Protein 8 2 3
  • Cytotoxic T-Lymphocyte-Associated Antigen 8 3 4
  • CTLA-8 3 4
  • IL-17A 3 4
  • CTLA8 3 4
  • IL-17 3 4
  • IL17 3 4
  • Interleukin-17A 3

External Ids for IL17A Gene

Previous HGNC Symbols for IL17A Gene

  • CTLA8
  • IL17

Previous GeneCards Identifiers for IL17A Gene

  • GC06P052160
  • GC06P052051
  • GC06P051882

Summaries for IL17A Gene

Entrez Gene Summary for IL17A Gene

  • The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL17A Gene

IL17A (Interleukin 17A) is a Protein Coding gene. Diseases associated with IL17A include Arthritis and Aspiration Pneumonia. Among its related pathways are PEDF Induced Signaling and Immune response IL-23 signaling pathway. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL17F.

UniProtKB/Swiss-Prot for IL17A Gene

  • Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).

Gene Wiki entry for IL17A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL17A Gene

Genomics for IL17A Gene

Regulatory Elements for IL17A Gene

Enhancers for IL17A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G052154 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -30.1 -30088 4.1 PKNOX1 FOXA2 TBL1XR1 RAD21 ETS1 SCRT2 FOS ETV6 IKZF2 CREM IL17F SLC25A20P1 IL17A PKHD1 MCM3 PAQR8 GC06P052155 GC06M052169
GH06G052101 0.8 ENCODE dbSUPER 10.2 -83.3 -83313 3.8 MAFF KLF1 ZNF316 CREB1 MAFG EMSY MAFK LINCMD1 MIR133B MIR206 IL17A SLC25A20P1 IL17F GC06P052124 PKHD1
GH06G052263 0.8 ENCODE 10 +77.5 77531 0.2 CTCF ZNF48 RAD21 RFX5 ZNF143 SMC3 NR2F6 THAP11 ZNF654 MAZ LINCMD1 MIR133B PKHD1 MIR206 IL17A SLC25A20P1 PIR36045
GH06G052216 0.5 ENCODE 11 +31.0 30970 1.1 IKZF1 TCF7 ZNF384 CEBPG IL17F SLC25A20P1 IL17A LINCMD1 MIR133B MIR206 PKHD1 LOC105375088 LOC102724327
GH06G052179 0.8 dbSUPER 0.7 -1.1 -1060 11.9 CTCF TBL1XR1 CEBPG RAD21 ARID3A SMC3 NFE2 MAFK NFE2L2 ZNF263 SLC25A20P1 IL17F LINCMD1 MIR133B MIR206 PKHD1 IL17A GC06P052177
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL17A on UCSC Golden Path with GeneCards custom track

Genomic Location for IL17A Gene

Chromosome:
6
Start:
52,186,387 bp from pter
End:
52,190,638 bp from pter
Size:
4,252 bases
Orientation:
Plus strand

Genomic View for IL17A Gene

Genes around IL17A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17A Gene

Proteins for IL17A Gene

  • Protein details for IL17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16552-IL17_HUMAN
    Recommended name:
    Interleukin-17A
    Protein Accession:
    Q16552
    Secondary Accessions:
    • Q5T2P0

    Protein attributes for IL17A Gene

    Size:
    155 amino acids
    Molecular mass:
    17504 Da
    Quaternary structure:
    • Homodimer (PubMed:19835883). Heterodimer with IL17F (PubMed:17355969).

    Three dimensional structures from OCA and Proteopedia for IL17A Gene

neXtProt entry for IL17A Gene

Post-translational modifications for IL17A Gene

Other Protein References for IL17A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for IL17A

No data available for DME Specific Peptides for IL17A Gene

Domains & Families for IL17A Gene

Gene Families for IL17A Gene

Protein Domains for IL17A Gene

Suggested Antigen Peptide Sequences for IL17A Gene

Graphical View of Domain Structure for InterPro Entry

Q16552

UniProtKB/Swiss-Prot:

IL17_HUMAN :
  • Belongs to the IL-17 family.
Family:
  • Belongs to the IL-17 family.
genes like me logo Genes that share domains with IL17A: view

Function for IL17A Gene

Molecular function for IL17A Gene

UniProtKB/Swiss-Prot Function:
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).

Gene Ontology (GO) - Molecular Function for IL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with IL17A: view
genes like me logo Genes that share phenotypes with IL17A: view

Animal Models for IL17A Gene

MGI Knock Outs for IL17A:

Animal Model Products

CRISPR Products

miRNA for IL17A Gene

miRTarBase miRNAs that target IL17A

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IL17A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL17A Gene

Localization for IL17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL17A gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
lysosome 2
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for IL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS,IEA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with IL17A: view

Pathways & Interactions for IL17A Gene

genes like me logo Genes that share pathways with IL17A: view

SIGNOR curated interactions for IL17A Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for IL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 7499828
GO:0006954 inflammatory response IEA --
GO:0006955 immune response TAS 7499828
GO:0007267 cell-cell signaling TAS 7499828
GO:0008219 cell death TAS 8390535
genes like me logo Genes that share ontologies with IL17A: view

Drugs & Compounds for IL17A Gene

(29) Drugs for IL17A Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ixekizumab Approved Pharma Target, antibody 0
Secukinumab Approved Pharma Target, antagonist 0
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
Y-320 Pharma 0
Vidofludimus Pharma inhibitor DHODH inhibitor 0

(21) Additional Compounds for IL17A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for IL17A Gene

Compound Action Cas Number
Y-320 288250-47-5
genes like me logo Genes that share compounds with IL17A: view

Drug Products

Transcripts for IL17A Gene

mRNA/cDNA for IL17A Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL17A Gene

Interleukin 17A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IL17A

Alternative Splicing Database (ASD) splice patterns (SP) for IL17A Gene

No ASD Table

Relevant External Links for IL17A Gene

GeneLoc Exon Structure for
IL17A
ECgene alternative splicing isoforms for
IL17A

Expression for IL17A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL17A Gene

mRNA differential expression in normal tissues according to GTEx for IL17A Gene

This gene is overexpressed in Minor Salivary Gland (x8.8), Esophagus - Mucosa (x8.2), Small Intestine - Terminal Ileum (x5.7), Vagina (x4.5), and Fallopian Tube (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of IL17A Gene:

IL17A

SOURCE GeneReport for Unigene cluster for IL17A Gene:

Hs.41724

mRNA Expression by UniProt/SwissProt for IL17A Gene:

Q16552-IL17_HUMAN
Tissue specificity: Restricted to activated memory T-cells.

Evidence on tissue expression from TISSUES for IL17A Gene

  • Blood(4.7)
  • Spleen(3.1)
  • Lymph node(2.9)
  • Intestine(2.8)
  • Lung(2.7)
  • Skin(2.7)
  • Nervous system(2.2)
  • Bone marrow(2.1)
  • Heart(2.1)
  • Liver(2)
genes like me logo Genes that share expression patterns with IL17A: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL17A Gene

Orthologs for IL17A Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL17A 34 35
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia IL17A 34
  • 86.67 (n)
IL-17A 35
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL17A 34
  • 84.69 (n)
IL17 35
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il17a 34
  • 77.05 (n)
mouse
(Mus musculus)
Mammalia Il17a 34 16 35
  • 74.62 (n)
oppossum
(Monodelphis domestica)
Mammalia IL17A 35
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL17A 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL17F 35
  • 40 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 35 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734167 34
  • 58.7 (n)
zebrafish
(Danio rerio)
Actinopterygii il17a/f3 35
  • 29 (a)
ManyToMany
il17a/f1 35
  • 27 (a)
ManyToMany
Species where no ortholog for IL17A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL17A Gene

ENSEMBL:
Gene Tree for IL17A (if available)
TreeFam:
Gene Tree for IL17A (if available)

Paralogs for IL17A Gene

Paralogs for IL17A Gene

(1) SIMAP similar genes for IL17A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IL17A: view

Variants for IL17A Gene

Sequence variations from dbSNP and Humsavar for IL17A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000402748 -- 52,187,484(+) ATTGT(C/T)CTGGA intron-variant
rs1000879143 -- 52,190,780(+) GAGGC(C/T)CATGG downstream-variant-500B
rs1001348709 -- 52,184,951(+) CCTCC(C/G)TCATT upstream-variant-2KB
rs1001565921 -- 52,187,337(+) GCCAA(C/T)CAATG intron-variant
rs1001598373 -- 52,187,138(+) GATTT(C/T)CTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL17A Gene

Variant ID Type Subtype PubMed ID
nsv522645 CNV gain 19592680
nsv830662 CNV gain 17160897

Variation tolerance for IL17A Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL17A Gene

Human Gene Mutation Database (HGMD)
IL17A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL17A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17A Gene

Disorders for IL17A Gene

MalaCards: The human disease database

(90) MalaCards diseases for IL17A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
arthritis
  • inflammatory disorder of joint
aspiration pneumonia
  • aspiration pneumonitis
acute generalized exanthematous pustulosis
  • agep
bronchiolitis obliterans
  • bronchiolitis exudativa
allergic contact dermatitis
  • dermatitis allergic contact
- elite association - COSMIC cancer census association via MalaCards
Search IL17A in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL17A

Genetic Association Database (GAD)
IL17A
Human Genome Epidemiology (HuGE) Navigator
IL17A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL17A
genes like me logo Genes that share disorders with IL17A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL17A Gene

Publications for IL17A Gene

  1. Structure of IL-17A in complex with a potent, fully human neutralizing antibody. (PMID: 19835883) Gerhardt S. … Russell C. (J. Mol. Biol. 2009) 3 4 22 64
  2. Interleukin-17A gene variants and risk of coronary artery disease: a large angiography-based study. (PMID: 21062626) Zhang X. … Han Y. (Clin. Chim. Acta 2011) 3 46 64
  3. Does IL-17 play a role in hepatic dysfunction of scrub typhus patients? (PMID: 19485773) Yoon H.J. … Yoo S.M. (Vector Borne Zoonotic Dis. 2010) 3 22 64
  4. A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour. (PMID: 19969371) Ito M. … Saito S. (J. Reprod. Immunol. 2010) 3 22 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for IL17A Gene

  • Addgene plasmids for IL17A

Sources for IL17A Gene

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