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IL17A Gene

protein-coding   GIFtS: 63
GCID: GC06P052051

Interleukin 17A

(Previous name: interleukin 17 (cytotoxic T-lymphocyte-associated serine...)
(Previous symbols: CTLA8, IL17)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 17A1 2     Cytotoxic T-Lymphocyte-Associated Antigen 82 3
CTLA81 2 3 5     CTLA-82 3
IL171 2 3 5     IL-172 3
Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)1 2     IL-17A2 3
Cytotoxic T-Lymphocyte-Associated Protein 81 2     interleukin-17A2

External Ids:    HGNC: 59811   Entrez Gene: 36052   Ensembl: ENSG000001121157   OMIM: 6031495   UniProtKB: Q165523   

Export aliases for IL17A gene to outside databases

Previous GC identifers: GC06P052160 GC06P051882


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL17A Gene:
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine
regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the
expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).
High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid
arthritis, psoriasis and multiple sclerosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL17A Gene:
IL17A (interleukin 17A) is a protein-coding gene. Diseases associated with IL17A include paranasal sinus disease, and duodenal disease. GO annotations related to this gene include cytokine activity. An important paralog of this gene is IL17F.

UniProtKB/Swiss-Prot: IL17_HUMAN, Q16552
Function: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface
expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts

Gene Wiki entry for IL17A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL17A gene promoter:
         STAT5B   STAT1   AP-1   ATF-2   STAT5A   CUTL1   C/EBPalpha   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL17A promoter sequence
   Search Chromatin IP Primers for IL17A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL17A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12   Ensembl cytogenetic band:  6p12.2   HGNC cytogenetic band: 6p12

IL17A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL17A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P052051:  view genomic region     (about GC identifiers)

Start:
52,051,185 bp from pter      End:
52,055,436 bp from pter
Size:
4,252 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IL17_HUMAN, Q16552 (See protein sequence)
Recommended Name: Interleukin-17A precursor  
Size: 155 amino acids; 17504 Da
Subunit: Homodimer
3 PDB 3D structures from and Proteopedia for IL17A:
2VXS (3D)        4HR9 (3D)        4HSA (3D)    
Secondary accessions: Q5T2P0

Explore the universe of human proteins at neXtProt for IL17A: NX_Q16552

Explore proteomics data for IL17A at MOPED

Post-translational modifications: 

  • Found both in glycosylated and nonglycosylated forms1
  • Glycosylation2 at Asn68
  • Modification sites at PhosphoSitePlus

  • See IL17A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002181.1  
    ENSEMBL proteins: 
     ENSP00000344192  

    IL17A Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

    IL17A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL17A
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    Novus Biologicals IL17A Antibodies
    Abcam antibodies for IL17A
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for IL17A
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    IL17A Assay Products:

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    Enzo Life Sciences assays for IL17A
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    2 InterPro protein domains:
     IPR010345 IL-17_fam
     IPR020440 IL-17_chr

    Graphical View of Domain Structure for InterPro Entry Q16552

    ProtoNet protein and cluster: Q16552

    1 Blocks protein domain: IPB010345 Interleukin-17

    UniProtKB/Swiss-Prot: IL17_HUMAN, Q16552
    Similarity: Belongs to the IL-17 family


    IL17A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL17_HUMAN, Q16552
    Function: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface
    expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
         
    IL17A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IL17A:
     Increased gamma-H2AX phosphory 

         10 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Il17a):
     craniofacial  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  no phenotypic analysis  renal/urinary system  respiratory system  skeleton 

    IL17A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Il17a/Il17fIl17a/tm1.1Impr for IL17A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL17A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL17A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL17A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL17A

    miRNA
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    miRTarBase miRNAs that target IL17A:
    hsa-mir-335-5p (MIRT016706)

    Block miRNA regulation of human, mouse, rat IL17A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL17A (see all 13):
    hsa-miR-3163 hsa-miR-875-3p hsa-miR-1266 hsa-miR-19b-2* hsa-miR-101* hsa-miR-606 hsa-miR-888 hsa-miR-3157-5p
    SwitchGear 3'UTR luciferase reporter plasmidIL17A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL17A
    Predesigned siRNA for gene silencing in human, mouse, rat IL17A

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: IL17A (NM_002190)
    Sino Biological Human cDNA Clone for IL17A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL17A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL17A

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL17_HUMAN, Q16552: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    plasma membrane2
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--
    GO:0009897external side of plasma membrane IEA--

    IL17A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL17A About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1IL-17 Family Signaling Pathways
    IL-17 Family Signaling Pathways0.51
    Mucin expression in CF via IL 6, IL 17 signaling pathways0.48
    IL17 signaling pathway0.51
    2Immune response IL 23 signaling pathway
    Immune response IL 23 signaling pathway0.41
    IL23-mediated signaling events0.38
    3Cytokine production by Th17 cells in CF
    Cytokine production by Th17 cells in CF0.72
    Cytokine production by Th17 cells in CF Mouse model 0.72
    4Th17 Differentiation
    Th17 Differentiation0.47
    5PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IL17A
        IL-17 Family Signaling Pathways
    Th17 Differentiation

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL17A (see all 25)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling

    4 GeneGo (Thomson Reuters) Pathways for IL17A
        Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF
    Mucin expression in CF via IL-6, IL-17 signaling pathways
    Immune response IL-23 signaling pathway

    4 BioSystems Pathways for IL17A
        TCR Signaling Pathway
    IL17 signaling pathway
    IL27-mediated signaling events
    IL23-mediated signaling events



    3 Kegg Pathways  (Kegg details for IL17A):
        Cytokine-cytokine receptor interaction
    Inflammatory bowel disease (IBD)
    Rheumatoid arthritis


    IL17A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL17A (see all 10): 
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat
              Th17 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL17A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for IL17A (Q165523 ENSP000003441924) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL17RAQ96F463, ENSP000003209364I2D: score=2 STRING: ENSP00000320936
    STAT3P407633, ENSP000002646574I2D: score=1 STRING: ENSP00000264657
    TRAF3IP2O437343, ENSP000003459844I2D: score=1 STRING: ENSP00000345984
    IL17RCQ8NAC33, ENSP000002959814I2D: score=1 STRING: ENSP00000295981
    IL17FQ96PD43I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation TAS7499828
    GO:0006915apoptotic process TAS7499828
    GO:0006954inflammatory response IEA--
    GO:0006955immune response TAS7499828
    GO:0007267cell-cell signaling TAS7499828

    IL17A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL17A (IL17)

    Selected Novoseek inferred chemical compound relationships for IL17A gene (see all 45)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 69.7 54 12165487 (6), 19927541 (5), 12372947 (2), 9646176 (1) (see all 39)
    groalpha 47.8 6 11067941 (3), 16542136 (1), 19819721 (1)
    sb 203580 45.3 13 15034939 (2), 15982617 (1), 12823853 (1), 18941244 (1) (see all 7)
    pge2 42.1 68 11592370 (4), 11327240 (4), 18698005 (3), 10328864 (2) (see all 22)
    vegf 41.3 75 15860217 (5), 16163444 (4), 17690908 (4), 20099977 (4) (see all 27)
    ionomycin 38.7 14 17425422 (3), 10679127 (3), 10328864 (2), 20045653 (2) (see all 7)
    infliximab 36.8 13 19728295 (3), 16680388 (3), 11950256 (1), 18092129 (1) (see all 6)
    pd 98,059 36.7 3 10833473 (1), 11777983 (1), 17652082 (1)
    etanercept 32.3 7 17619881 (2), 18763027 (2), 18466711 (1), 18039949 (1) (see all 9)
    curdlan 28 1 20401539 (1)



    IL17A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IL17A gene: 
    NM_002190.2  

    Unigene Cluster for IL17A:

    Interleukin 17A
    Hs.41724  [show with all ESTs]
    Unigene Representative Sequence: U32659
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000340057(uc003pak.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Selected qRT-PCR Assays for microRNAs that regulate IL17A (see all 13):
    hsa-miR-3163 hsa-miR-875-3p hsa-miR-1266 hsa-miR-19b-2* hsa-miR-101* hsa-miR-606 hsa-miR-888 hsa-miR-3157-5p
    SwitchGear 3'UTR luciferase reporter plasmidIL17A 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat IL17A

    Additional mRNA sequence: 

    BC066251.1 BC066252.1 BC066253.1 BC067503.1 BC067504.1 BC067505.1 HM535222.1 U32659.1 
    Z58820.1 

    1 DOTS entry:

    DT.101977073 

    20 AceView cDNA sequences:

    CD559442 BC066252 NM_002190 BC067503 BC067505 CD559595 CD559600 BC067504 
    BC066253 CK130280 CD559599 CD559596 U32659 BC066251 CD559598 Z58820 
    CD559597 CD559601 CD559443 CD559447 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL17A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATTATTAA
    IL17A Expression
    About this image


    IL17A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     NULL (Uncategorized)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
    IL17A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL17A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.41724

    UniProtKB/Swiss-Prot: IL17_HUMAN, Q16552
    Tissue specificity: Restricted to activated memory T-cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL17A (see all 10): 
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat
              Th17 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat IL17A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL17A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL17A gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il17a1 , 5 interleukin 17A1, 5 74.62(n)1
    61.29(a)1
      1 (6.45 cM)5
    161711  NM_010552.31  NP_034682.11 
     207309055 
    chicken
    (Gallus gallus)
    Aves IL17F6
    Gallus gallus interleukin 17F (IL17F), mRNA.
    40(a)
    many ↔ many
    3(107193900-107196824)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    35(a)
    1 → many
    1(122877292-122881562)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017341671 interleukin-17A-like 58.7(n)
    51.33(a)
      101734167  XM_004914981.1  XP_004915038.1 
    zebrafish
    (Danio rerio)
    Actinopterygii il17a/f36
    il17a/f16
    interleukin 17a/f1
    29(a)
    27(a)
    many ↔ many
    many ↔ many
    20(34816774-34819073) ENSDARG00000041976
    17(12573842-12576188) ENSDARG00000043933


    ENSEMBL Gene Tree for IL17A (if available)
    TreeFam Gene Tree for IL17A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL17A gene
    IL17F2  IL17C2  
    1 SIMAP similar gene for IL17A using alignment to 2 protein entries:     IL17_HUMAN (see all proteins):
    IL17F

    IL17A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL17A (see all 144)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1151416681,2
    C,F--51961818(+) GGTAAG/ACTTTG 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1884896211,2
    --51961885(+) GGGGGC/TAAGGC 1 -- us2k10--------
    rs1166364661,2
    F--51962083(+) GGGTGA/GGAGTG 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1167329361,2
    C,F--51962112(+) GAAATT/CGGTGA 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs2010808461,2
    C--51962168(-) GCCCCC/TCCTCT 1 -- us2k10--------
    rs1931484071,2
    --51962191(+) TCTGAA/GTCTTG 1 -- us2k10--------
    rs1849425931,2
    --51962238(+) GACTAC/TGGAAA 1 -- us2k10--------
    rs1475112241,2
    --51962305(+) GATATC/GTACTA 1 -- us2k10--------
    rs178822151,2
    C,F--51962400(+) ATTTGC/TAACAG 1 -- us2k13Minor allele frequency- T:0.01NS NA 88
    rs121952731,2
    C,F,H--51962613(+) CCTAGC/ATGAAA 1 -- us2k14Minor allele frequency- A:0.00NS EA 420

    HapMap Linkage Disequilibrium report for IL17A (52051185 - 52055436 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IL17A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522645CNV Gain19592680
    nsv830662CNV Gain17160897

    Human Gene Mutation Database (HGMD): IL17A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL17A
    DNA2.0 Custom Variant and Variant Library Synthesis for IL17A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603149    OMIM disorders: --

    Selected diseases for IL17A (see all 225):    
    About MalaCards
    paranasal sinus disease    duodenal disease    autosomal dominant hyper ige syndrome    myelitis
    bronchiolitis obliterans    autoimmune encephalitis    keratitis    transverse myelitis
    autoimmune enteropathy    psoriasis    multiple sclerosis    autoimmune polyendocrine syndrome type 1
    bronchiolitis    hyper ige syndrome    stromal keratitis    autoimmune polyendocrine syndrome
    secondary progressive multiple sclerosis    trachoma    autoimmune disease of central nervous system    toxoplasmosis

    3 diseases from the University of Copenhagen DISEASES database for IL17A:
    Arthritis     Hypersensitivity reaction type II disease     Multiple sclerosis

    IL17A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for IL17A gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 79.7 66 18004573 (2), 19234216 (2), 16815032 (2), 16200068 (1) (see all 49)
    rheumatoid arthritis 78.5 132 18033994 (5), 10679127 (5), 19798029 (3), 14984588 (3) (see all 80)
    autoimmunity 78.4 47 17942669 (1), 19109162 (1), 19101114 (1), 19444307 (1) (see all 30)
    inflammation 78 205 19783683 (3), 15901616 (3), 18941201 (3), 12678335 (2) (see all 99)
    encephalomyelitis 70.3 19 19055697 (2), 18156204 (2), 16200068 (1), 18424707 (1) (see all 14)
    arthritis 69.4 103 12721360 (5), 15972960 (4), 11441109 (4), 18039580 (4) (see all 50)
    necrosis 67.7 194 12661990 (2), 15845864 (2), 16143885 (2), 15229940 (2) (see all 99)
    psoriasis 66.6 53 15315354 (3), 18981165 (3), 18763027 (3), 19330474 (2) (see all 23)
    bone destruction 65 15 11299057 (2), 19252243 (1), 18033994 (1), 11407688 (1) (see all 9)
    multiple sclerosis 62.4 28 18156204 (2), 18164424 (1), 18063700 (1), 18417225 (1) (see all 20)

    Genetic Association Database (GAD): IL17A
    Human Genome Epidemiology (HuGE) Navigator: IL17A (48 documents)

    Export disorders for IL17A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL17A gene, integrated from 10 sources (see all 1491):
    (articles sorted by number of sources associating them with IL17A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of IL-17A in complex with a potent, fully human neutralizing antibody. (PubMed id 19835883)1, 2, 9 Gerhardt S.... Russell C. (J. Mol. Biol. 2009)
    2. Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis. (PubMed id 17876645)1, 4, 9 Furuya T....Kotake S. (Clin. Rheumatol. 2007)
    3. Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis. (PubMed id 19414056)1, 4, 9 Shibata T....Arisawa T. (Hum. Immunol. 2009)
    4. Interleukin-17A gene variants and risk of coronary artery disease: a large angiography-based study. (PubMed id 21062626)1, 4 Zhang X....Han Y. ( international journal of clinical chemistry 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Association between polymorphisms in interleukin-17A and interleukin-17F genes and risks of gastric cancer. (PubMed id 19904747)1, 4 Wu X....Hu P. (Int. J. Cancer 2010)
    7. The polymorphism of IL-17 G-152A was associated with childhood asthma and bacterial colonization of the hypopharynx in bronchiolitis. (PubMed id 20437253)1, 4 Chen J....Liu E. (J. Clin. Immunol. 2010)
    8. Polymorphisms in cytokine genes and serum cytokine levels among New Mexican women with and without breast cancer. (PubMed id 20418110)1, 4 Erdei E....Berwick M. (Cytokine 2010)
    9. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    10. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3605 HGNC: 5981 AceView: IL17 Ensembl:ENSG00000112115 euGenes: HUgn3605
    ECgene: IL17A Kegg: 3605 H-InvDB: IL17A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL17A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL17A Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine mini-reviews: IL-17http://www.rndsystems.com/molecule_detail.aspx?m=1674
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_17
    SeattleSNPshttp://pga.gs.washington.edu/data/il17/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL17A gene:
    Search GeneIP for patents involving IL17A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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