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IL16 Gene

protein-coding   GIFtS: 61
GCID: GC15P081489

Interleukin 16

(Previous name: interleukin 16 (lymphocyte chemoattractant factor))
  See IL16-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 161 2     NIL162
Lymphocyte Chemoattractant Factor1 2     PRIL162
Prointerleukin 161 2     Neuronal Interleukin 162
LCF2 5     prIL-162
Interleukin 16 (Lymphocyte Chemoattractant Factor)1     pro-interleukin-162

External Ids:    HGNC: 59801   Entrez Gene: 36032   Ensembl: ENSG000001723497   OMIM: 6030355   UniProtKB: Q140053   

Export aliases for IL16 gene to outside databases

Previous GC identifers: GC15P077545 GC15P074632 GC15P079051 GC15P079190 GC15P079262 GC15P079276 GC15P058247


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL16 Gene:
The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T
cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4.
The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The
cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may
play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this
protein. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Feb 2010)

GeneCards Summary for IL16 Gene:
IL16 (interleukin 16) is a protein-coding gene. Diseases associated with IL16 include vasomotor rhinitis, and whiplash. GO annotations related to this gene include cytokine activity. An important paralog of this gene is PARD3B.

UniProtKB/Swiss-Prot: IL16_HUMAN, Q14005
Function: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes
CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor.
Ligand for CD4
Function: Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane
Function: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional
regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2
gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3
thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells

Gene Wiki entry for IL16 (Interleukin 16) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL16 gene promoter:
         USF1   STAT1   USF2   STAT1beta   USF-1:USF-2   Tal-1beta   E47   STAT1alpha   USF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL16 promoter sequence
   Search Chromatin IP Primers for IL16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q26.3

IL16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL16 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P081489:  view genomic region     (about GC identifiers)

Start:
81,451,916 bp from pter      End:
81,605,104 bp from pter
Size:
153,189 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL16_HUMAN, Q14005 (See protein sequence)
Recommended Name: Pro-interleukin-16  
Size: 1332 amino acids; 141752 Da
Subunit: Homotetramer (Probable). According to PubMed:9699630, the formation of a homotetrameric protein complex
is not required for the chemo-attractant function. Isoform 3 interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B
and PPP1R12C. Isoform 1 interacts with PPP1R12B. Isoform 3 interacts with GRIN2A. Isoform 3 interacts with
GABPB1. Isoform 3 interacts (via PDZ 3 domain) with HDAC3. Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and
CACNA1C (By similarity). Isoform 3 interacts with HTLV-1 tax
2 PDB 3D structures from and Proteopedia for IL16:
1I16 (3D)        1X6D (3D)    
Secondary accessions: A6NM20 A8MU65 B9EGR6 Q16435 Q6VVE6 Q6ZMQ7 Q9UP18
Alternative promoter usage, Alternative splicing: 3 isoforms:  Q14005-1   Q14005-2   Q14005-3   (Produced by alternative promoter usage. Is proteolytically processed to yield IL-16)

Explore the universe of human proteins at neXtProt for IL16: NX_Q14005

Explore proteomics data for IL16 at MOPED

Post-translational modifications: 

  • Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically
    cleaved by caspase-3 to yield IL-161
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IL16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001165599.1  NP_004504.3  NP_757366.2  

    ENSEMBL proteins: 
     ENSP00000452738   ENSP00000458125   ENSP00000456972   ENSP00000453250   ENSP00000378155  
     ENSP00000302935   ENSP00000454636   ENSP00000378147   ENSP00000453131   ENSP00000453214  

    IL16 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL16 (IL-16)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for IL16
    OriGene Protein Over-expression Lysate for IL16
    OriGene MassSpec for IL16
    OriGene Custom Protein Services for IL16
    GenScript Purified and Recombinant Proteins for IL16
    Novus Biologicals IL16 Proteins
    Novus Biologicals IL16 Lysates
    Sino Biological Recombinant Protein for IL16
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for IL16
    Cloud-Clone Corp. Proteins for IL16

     
    eBioscience Proteins for IL16:  
                        Human IL-16 Recombinant Protein 5 ug

    IL16 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL16
    R&D Systems Antibodies for IL16 (IL-16)
    OriGene Antibodies for IL16
    OriGene Custom Antibody Services for IL16
    Novus Biologicals IL16 Antibodies
    Abcam antibodies for IL16
    Cloud-Clone Corp. Antibodies for IL16
    ThermoFisher Antibody for IL16
    LSBio Antibodies in human, mouse, rat for IL16

    IL16 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL16
    R&D Systems ELISAs for IL16 (IL-16)         (see all)
    GenScript Custom Assay Services for IL16
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL16
    Cloud-Clone Corp. CLIAs for IL16
    Search eBioscience for ELISAs for IL16 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    2 InterPro protein domains:
     IPR020450 IL-16
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q14005

    ProtoNet protein and cluster: Q14005

    UniProtKB/Swiss-Prot: IL16_HUMAN, Q14005
    Similarity: Contains 4 PDZ (DHR) domains


    Find genes that share domains with IL16           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL16_HUMAN, Q14005
    Function: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes
    CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor.
    Ligand for CD4
    Function: Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane
    Function: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional
    regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2
    gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3
    thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells
    Induction: Isoform 3 is down-regulated in T-cells after TCR activation

         Genatlas biochemistry entry for IL16:
    interleukin 16,T cell derived cytokine,lymphocyte chemoattractant factor,inducing the chemotactic and
    immunomodulatory responses of ED4+ lymphocytes monocytes and eosinophils

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with IL16           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for IL16:
     Increased cell death in breast  Increased cell number in G2M,  

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il16):
     hematopoietic system  immune system 

    Find genes that share phenotypes with IL16           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Il16tm1Korn for IL16

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL16
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL16

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL16
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL16

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat IL16 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL16 (see all 20):
    hsa-miR-3149 hsa-miR-125a-5p hsa-miR-188-5p hsa-miR-4251 hsa-miR-3150a-3p hsa-miR-515-5p hsa-miR-125b hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidIL16 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL16
    Predesigned siRNA for gene silencing in human, mouse, rat IL16

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL16

    Clone
    Products:
         
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    OriGene ORF clones in mouse, rat for IL16
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IL16 (NM_004513)
    Sino Biological Human cDNA Clone for IL16
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL16

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL16
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL16 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL16


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL16_HUMAN, Q14005: Interleukin-16: Secreted
    IL16_HUMAN, Q14005: Isoform 1: Cytoplasm (By similarity)
    IL16_HUMAN, Q14005: Isoform 3: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus5
    plasma membrane4
    cytosol3
    mitochondrion2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with IL16           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL16 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    MAPK Family Pathway0.60
    SOCS Pathway0.40
    JAK-STAT Pathway0.57
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    5PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL16 (see all 25)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling



        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL16 (see all 7): 
              HIV Host Response in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL16 (Q140053 ENSP000003029354) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNJ2P632523, ENSP000002434574I2D: score=5 STRING: ENSP00000243457
    KCND1Q9NSA23, ENSP000002181764I2D: score=4 STRING: ENSP00000218176
    KCNJ4P480503, ENSP000003064974I2D: score=4 STRING: ENSP00000306497
    PPP1R12AO149743, ENSP000002612074I2D: score=4 STRING: ENSP00000261207
    CACNA1CQ139363, ENSP000002663764I2D: score=3 STRING: ENSP00000266376
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006955immune response TAS9144227
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----

    Find genes that share ontologies with IL16           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL16

    Selected Novoseek inferred chemical compound relationships for IL16 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    il 16 92 25 19279017 (8), 16387589 (4), 14657881 (2), 10593485 (1) (see all 6)
    rantes 81.2 72 8786320 (5), 16410300 (5), 12390317 (4), 11971026 (3) (see all 40)
    histamine 16.7 17 10572065 (4), 9648706 (4), 11264709 (1), 12001788 (1) (see all 5)
    fluticasone propionate 12.1 3 12872394 (2)
    ccl4 9.93 2 17716649 (1)
    calcium 2.65 4 11971026 (1), 11937573 (1), 8955168 (1), 1673145 (1)
    dexamethasone 2.17 7 10572065 (2), 11574756 (2), 9566794 (1), 15322222 (1)
    lipid 1.48 2 11971026 (1)
    thymidine 0 3 8955168 (1), 9498748 (1)
    nitric oxide 0 6 12972516 (1), 11859968 (1), 17083347 (1)



    Find genes that share compounds with IL16           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL16 gene (3 alternative transcripts): 
    NM_001172128.1  NM_004513.5  NM_172217.3  

    Unigene Cluster for IL16:

    Interleukin 16
    Hs.459095  [show with all ESTs]
    Unigene Representative Sequence: AL833554
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560989 ENST00000560241(uc002bgc.2) ENST00000559388(uc010blq.1)
    ENST00000360547 ENST00000559383 ENST00000394660(uc002bge.4 uc010unp.2 uc021ssg.1 uc002bgg.3 uc021ssh.1 uc002bgj.3 uc021ssi.1)
    ENST00000302987 ENST00000560115(uc002bgi.1) ENST00000394652 ENST00000560230
    ENST00000558857(uc002bgl.1) ENST00000558332(uc010unq.1) ENST00000559342
    ENST00000559953
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate IL16 (see all 20):
    hsa-miR-3149 hsa-miR-125a-5p hsa-miR-188-5p hsa-miR-4251 hsa-miR-3150a-3p hsa-miR-515-5p hsa-miR-125b hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidIL16 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IL16
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    GenScript: all cDNA clones in your preferred vector (see all 3): IL16 (NM_004513)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL16
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL16
      QuantiTect SYBR Green Assays in human, mouse, rat IL16
      QuantiFast Probe-based Assays in human, mouse, rat IL16

    Additional mRNA sequence: 

    AF053412.1 AK124565.1 AK124725.1 AK126222.1 AK128740.1 AK131530.1 AK222512.1 AK308440.1 
    AL109669.1 AL109774.1 AL833554.1 AY324389.1 BC050362.1 BC064911.1 BC136660.1 FJ032370.1 
    M90391.1 S81601.1 U82972.1 

    17 DOTS entries:

    DT.97762189  DT.442856  DT.97841669  DT.315276  DT.101983198  DT.101983197  DT.99996357  DT.101973954 
    DT.100782086  DT.100782084  DT.70104227  DT.86854787  DT.91694277  DT.121017287  DT.121017298  DT.121017334 
    DT.75191066 

    Selected AceView cDNA sequences (see all 140):

    NM_172217 BC064911 NM_004513 BM981332 AL109774 AA765876 BQ223387 AI079472 
    BC050362 AK128740 AI457472 AK131530 CD618876 BX436325 BI825110 AI253583 
    AL833554 AW027723 AI696066 AI580343 AL582118 BX110752 BQ059496 BQ897936 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IL16 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d · 14e · 14f ^ 15 ^ 16a · 16b · 16c ^
    SP1:        -     -     -                                                                                                                                       
    SP2:                                                                                      -           -                                                         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 17a · 17b · 17c · 17d · 17e ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b · 22c ^ 23a · 23b · 23c
    SP1:                                                                                                            
    SP2:                                                                                                            
    SP3:                                      -                       -                                             
    SP4:                                                              -                                             
    SP5:                                                        -     -                                             


    ECgene alternative splicing isoforms for IL16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IL16 Expression
    About this image


    IL16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Thymus (Hematopoietic System)
             Thymus
     
     Lung (Respiratory System)
             Trachea
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    IL16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.459095

    UniProtKB/Swiss-Prot: IL16_HUMAN, Q14005
    Tissue specificity: Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable
    during active T-cell proliferation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL16 (see all 7): 
              HIV Host Response in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Common Cytokines in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for IL16 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il161 , 5 interleukin 161, 5 82.13(n)1
    81.5(a)1
      7 (47.43 cM)5
    161701  NM_010551.31  NP_034681.21 
     836428485 
    chicken
    (Gallus gallus)
    Aves IL161 interleukin 16 60.93(n)
    57.07(a)
      374270  NM_001277996.1  NP_001264925.1 
    lizard
    (Anolis carolinensis)
    Reptilia aca-mir-54026
    aca-mir-5402
    50(a)
    1 ↔ 1
    GL343894.1(78348-112775)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia il161 interleukin 16 56.5(n)
    51.99(a)
      100493920  XM_002932267.2  XP_002932313.2 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01068274.16
    Uncharacterized protein
    34(a)
    1 ↔ 1
    7(12277032-12401591) ENSDARG00000039884
    fruit fly
    (Drosophila melanogaster)
    Insecta bbg6
    big bang
    10(a)
    1 ↔ 1
    3L(14405925-14529376)


    ENSEMBL Gene Tree for IL16 (if available)
    TreeFam Gene Tree for IL16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL16 gene
    PARD3B2  PDZD22  INADL2  LNX22  PARD32  MPDZ2  LNX12  
    9 SIMAP similar genes for IL16 using alignment to 11 protein entries:     IL16_HUMAN (see all proteins):
    DKFZp686O23186    MPDZ    GRIP1    SYNJ2BP    DLG4    TJP2
    FRMPD2    PDZD2    PARD3

    Find genes that share paralogs with IL16           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL16 (see all 2711)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs681064441,2
    C--58315238(+) CAGAA-/GTGTGC 2 -- int10--------
    rs345226101,2
    C--58353656(+) TGTGT-/G/GTGT/G
    TGTGTGT
    /TG
    CACAC
    3 -- int10--------
    rs668497231,2
    C--58353656(+) AGTAATGTG/-  
            
    TGTGT
    3 -- int11Minor allele frequency- -:0.50NA 2
    rs1120543861,2
    C--58353656(+) AGTAATGTGTGTG
    TGTGTG
    /-
    TGTGT
    3 -- int11Minor allele frequency- -:0.50CSA 2
    rs587548821,2
    C--58353657(+) GTAATG/ATGTGT 3 -- int11Minor allele frequency- A:0.50WA 2
    rs757120031,2
    C,F--58362150(+) GTCACG/ATGGAG 3 -- ut311Minor allele frequency- A:0.03NA 120
    rs178755681,2
    C,F--58363039(+) GGAAGA/GCAGAG 3 -- ut313Minor allele frequency- G:0.10NS WA 208
    rs1872334291,2
    --61526093(+) AGCTTC/TAAGTG 1 -- us2k10--------
    rs740300071,2
    C,F--61526102(+) TGGTGC/TTTGAA 1 -- us2k13Minor allele frequency- T:0.22WA CSA 122
    rs1468019341,2
    --61526112(+) ACTTCC/GTAGTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL16 (81451916 - 81605104 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL16:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv904436CNV Loss21882294

    Human Gene Mutation Database (HGMD): IL16
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL16
    DNA2.0 Custom Variant and Variant Library Synthesis for IL16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603035    OMIM disorders: --

    4 diseases for IL16:    
    About MalaCards
    vasomotor rhinitis    whiplash    viral meningitis    cerebral artery occlusion


    Find genes that share disorders with IL16           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL16 gene (see all 49)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dermatitis atopic 52.4 31 17166405 (8), 12926794 (4), 11714796 (2), 11941319 (2) (see all 13)
    asthma allergic 50.5 11 9510204 (3), 9271307 (2), 17303923 (2), 10585533 (1) (see all 6)
    inflammation 49.8 51 16729885 (4), 10857846 (3), 11240948 (3), 17982032 (3) (see all 31)
    asthma 46.1 56 10903228 (7), 10932073 (6), 16522229 (6), 11775918 (3) (see all 19)
    graves disease 46 8 18394967 (4), 15322222 (2), 16410300 (1)
    bronchoalveolar lavage fluid 44.3 9 9648706 (2), 7576712 (1), 15373908 (1), 9510204 (1) (see all 6)
    immunodeficiency 42.5 22 9841826 (2), 10400800 (2), 11196708 (1), 10447738 (1) (see all 12)
    necrosis 42 31 8751236 (3), 10572065 (1), 11483776 (1), 17031175 (1) (see all 25)
    allergic rhinitis 38.4 16 11551252 (4), 16103689 (4), 11424872 (3), 15886011 (1) (see all 7)
    rheumatoid arthritis 34.7 22 10875316 (3), 18446062 (2), 14705216 (2), 11196512 (1) (see all 15)

    Genetic Association Database (GAD): IL16
    Human Genome Epidemiology (HuGE) Navigator: IL16 (38 documents)

    Export disorders for IL16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL16 gene, integrated from 10 sources (see all 367):
    (articles sorted by number of sources associating them with IL16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The association of interleukin-16 polymorphisms with IL-16 serum levels and risk of colorectal and gastric cancer. (PubMed id 19073878)1, 4, 9 Gao L.B....Zhang L. (Carcinogenesis 2009)
    2. Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor. (PubMed id 9144227)1, 3, 9 Baier M.... Kurth R. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    3. Genetic polymorphism of interleukin-16 and risk of nasopharyngeal carcinoma. (PubMed id 19758567)1, 4, 9 Gao L.B....Zhang L. ( international journal of clinical chemistry 2009)
    4. Association of the interleukin (IL)-16 gene polymorphisms with Graves' disease. (PubMed id 18394967)1, 4, 9 Gu X.J....Zhao Y.J. (Clin. Immunol. 2008)
    5. Association between the polymorphisms of IL-4 gene promoter (-590C&gt;T), IL-13 coding region (R130Q) and IL-16 gene promoter (-295T&gt;C) and allergic asthma. (PubMed id 17303923)1, 4, 9 Hosseini-Farahabadi S....Khaje Daluei M. (Iran J Allergy Asthma Immunol 2007)
    6. Association of asthma with a functional promoter polymorphism in the IL16 gene. (PubMed id 16387589)1, 4, 9 Burkart K.M....O'Connor G.T. (J. Allergy Clin. Immunol. 2006)
    7. The IL-16 gene polymorphisms and the risk of the systemic lupus erythematosus. (PubMed id 19298795)1, 4, 9 Xue H....Zhang L. ( international journal of clinical chemistry 2009)
    8. A polymorphism in the promoter region of the human interleukin-16 gene is not associated with asthma or atopy in an Australian population. (PubMed id 15784111)1, 4, 9 Akesson L.S....Kedda M.A. (Clin. Exp. Allergy 2005)
    9. Association of allergic contact dermatitis with a promoter polymorphism in the IL16 gene. (PubMed id 14657881)1, 4, 9 Reich K....Schnuch A. (J. Allergy Clin. Immunol. 2003)
    10. Allograft TNFbeta and IL16 polymorphisms influence HCV recurrence and severity after liver transplantation. (PubMed id 16447204)1, 4, 9 Kimball P....Fisher R.A. (Liver Transpl. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3603 HGNC: 5980 AceView: IL16 Ensembl:ENSG00000172349 euGenes: HUgn3603
    ECgene: IL16 H-InvDB: IL16

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IL16 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL16 Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine source book: IL-16http://www.rndsystems.com/molecule_detail.aspx?m=1673
    SeattleSNPshttp://pga.gs.washington.edu/data/il16/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL16 gene:
    Search GeneIP for patents involving IL16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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