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Aliases for IL16 Gene

Aliases for IL16 Gene

  • Interleukin 16 2 3
  • Lymphocyte Chemoattractant Factor 2 3
  • Prointerleukin 16 2 3
  • Interleukin 16 (Lymphocyte Chemoattractant Factor) 2
  • Neuronal Interleukin 16 3
  • PrIL-16 3
  • PRIL16 3
  • NIL16 3
  • LCF 3

External Ids for IL16 Gene

Previous GeneCards Identifiers for IL16 Gene

  • GC15P077545
  • GC15P074632
  • GC15P079051
  • GC15P079190
  • GC15P079262
  • GC15P079276
  • GC15P081489
  • GC15P058247

Summaries for IL16 Gene

Entrez Gene Summary for IL16 Gene

  • The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

GeneCards Summary for IL16 Gene

IL16 (Interleukin 16) is a Protein Coding gene. Diseases associated with IL16 include whipple disease and whiplash. Among its related pathways are TGF-Beta Pathway and Akt Signaling. GO annotations related to this gene include cytokine activity. An important paralog of this gene is PARD3B.

UniProtKB/Swiss-Prot for IL16 Gene

  • Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4

  • Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane

  • Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells

Gene Wiki entry for IL16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL16 Gene

Genomics for IL16 Gene

Regulatory Elements for IL16 Gene

Genomic Location for IL16 Gene

Chromosome:
15
Start:
81,159,575 bp from pter
End:
81,314,058 bp from pter
Size:
154,484 bases
Orientation:
Plus strand

Genomic View for IL16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL16 Gene

Proteins for IL16 Gene

  • Protein details for IL16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14005-IL16_HUMAN
    Recommended name:
    Pro-interleukin-16
    Protein Accession:
    Q14005
    Secondary Accessions:
    • A6NM20
    • A8MU65
    • B5TY35
    • B9EGR6
    • H3BVH5
    • Q16435
    • Q6VVE6
    • Q6ZMQ7
    • Q9UP18

    Protein attributes for IL16 Gene

    Size:
    1332 amino acids
    Molecular mass:
    141752 Da
    Quaternary structure:
    • Homotetramer (Probable). According to PubMed:9699630, the formation of a homotetrameric protein complex is not required for the chemo-attractant function. Isoform 3 interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Isoform 1 interacts with PPP1R12B. Isoform 3 interacts with GRIN2A. Isoform 3 interacts with GABPB1. Isoform 3 interacts (via PDZ 3 domain) with HDAC3. Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and CACNA1C (By similarity). Isoform 3 interacts with HTLV-1 tax.

    Three dimensional structures from OCA and Proteopedia for IL16 Gene

    Alternative splice isoforms for IL16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL16 Gene

Proteomics data for IL16 Gene at MOPED

Post-translational modifications for IL16 Gene

  • Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for IL16 Gene

Domains & Families for IL16 Gene

Gene Families for IL16 Gene

Protein Domains for IL16 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL16 Gene

Graphical View of Domain Structure for InterPro Entry

Q14005

UniProtKB/Swiss-Prot:

IL16_HUMAN :
  • Contains 4 PDZ (DHR) domains.
Domain:
  • Contains 4 PDZ (DHR) domains.
genes like me logo Genes that share domains with IL16: view

Function for IL16 Gene

Molecular function for IL16 Gene

GENATLAS Biochemistry:
interleukin 16,T cell derived cytokine,lymphocyte chemoattractant factor,inducing the chemotactic and immunomodulatory responses of ED4+ lymphocytes monocytes and eosinophils
UniProtKB/Swiss-Prot Function:
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4
UniProtKB/Swiss-Prot Function:
Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane
UniProtKB/Swiss-Prot Function:
Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells
UniProtKB/Swiss-Prot Induction:
Isoform 3 is down-regulated in T-cells after TCR activation.

Gene Ontology (GO) - Molecular Function for IL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IL16: view
genes like me logo Genes that share phenotypes with IL16: view

Animal Models for IL16 Gene

MGI Knock Outs for IL16:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL16

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for IL16 Gene

Localization for IL16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL16 Gene

Interleukin-16: Secreted.
Isoform 1: Cytoplasm.
Isoform 3: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL16 Gene COMPARTMENTS Subcellular localization image for IL16 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for IL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with IL16: view

Pathways & Interactions for IL16 Gene

genes like me logo Genes that share pathways with IL16: view

Pathways by source for IL16 Gene

PCR Array Products

SIGNOR curated interactions for IL16 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006955 immune response TAS 9144227
GO:0016032 viral process IEA --
GO:0030595 leukocyte chemotaxis IEA --
genes like me logo Genes that share ontologies with IL16: view

Drugs & Compounds for IL16 Gene

(12) Drugs for IL16 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational Pharma Agonist 1806
Fluticasone propionate Approved Pharma Selective high affinity glucocorticoid receptor agonist 0
Nitric Oxide Approved Pharma 540
Tacrolimus Approved, Investigational Pharma 992
Theophylline Approved Pharma Antagonist 55

(6) Additional Compounds for IL16 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
IL 16
LIPID
RANTES
Steroid
superoxide
  • Dioxidanidyl
  • Dioxide(1-)
  • Hyperoxid
  • Superoxide
  • Superoxide anion
11062-77-4
genes like me logo Genes that share compounds with IL16: view

Transcripts for IL16 Gene

Unigene Clusters for IL16 Gene

Interleukin 16:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL16

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL16 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d · 14e · 14f ^ 15 ^ 16a · 16b · 16c ^
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 17a · 17b · 17c · 17d · 17e ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b · 22c ^ 23a · 23b · 23c
SP1:
SP2:
SP3: - -
SP4: -
SP5: - -
SP6: -
SP7: -
SP8:
SP9:
SP10: - -
SP11:
SP12:

Relevant External Links for IL16 Gene

GeneLoc Exon Structure for
IL16
ECgene alternative splicing isoforms for
IL16

Expression for IL16 Gene

mRNA expression in normal human tissues for IL16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL16 Gene

This gene is overexpressed in Whole Blood (x10.2), Brain - Cerebellar Hemisphere (x4.5), and Brain - Cerebellum (x4.3).

Protein differential expression in normal tissues from HIPED for IL16 Gene

This gene is overexpressed in Lymph node (24.4), CD8 Tcells (11.4), Tlymphocyte (9.7), and Peripheral blood mononuclear cells (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IL16 Gene



SOURCE GeneReport for Unigene cluster for IL16 Gene Hs.459095

mRNA Expression by UniProt/SwissProt for IL16 Gene

Q14005-IL16_HUMAN
Tissue specificity: Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation
genes like me logo Genes that share expression patterns with IL16: view

Protein tissue co-expression partners for IL16 Gene

Primer Products

In Situ Assay Products

Orthologs for IL16 Gene

This gene was present in the common ancestor of animals.

Orthologs for IL16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL16 35
  • 82.02 (n)
  • 77.69 (a)
IL16 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL16 35
  • 83.26 (n)
  • 81.85 (a)
IL16 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il16 35
  • 82.13 (n)
  • 81.5 (a)
Il16 16
Il16 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL16 35
  • 99.35 (n)
  • 99.32 (a)
IL16 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il16 35
  • 82.08 (n)
  • 80.21 (a)
oppossum
(Monodelphis domestica)
Mammalia IL16 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL16 36
  • 6 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL16 35
  • 60.93 (n)
  • 57.07 (a)
IL16 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-5402 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il16 35
  • 56.5 (n)
  • 51.99 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01068274.1 36
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bbg 36
  • 10 (a)
OneToOne
Species with no ortholog for IL16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL16 Gene

ENSEMBL:
Gene Tree for IL16 (if available)
TreeFam:
Gene Tree for IL16 (if available)

Paralogs for IL16 Gene

Paralogs for IL16 Gene

genes like me logo Genes that share paralogs with IL16: view

Variants for IL16 Gene

Sequence variations from dbSNP and Humsavar for IL16 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs859 -- 81,308,981(+) CTAAA(A/G)TAAGG utr-variant-3-prime
rs1028 -- 81,308,968(+) CAAAA(A/G)GTTGT utr-variant-3-prime
rs11325 -- 81,308,999(+) CACAC(G/T)GGGGC utr-variant-3-prime
rs884819 -- 81,196,468(+) TTGAA(C/T)CCCCC upstream-variant-2KB, intron-variant
rs925272 -- 81,219,849(+) AAACA(C/T)TCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL16 Gene

Variant ID Type Subtype PubMed ID
nsv904436 CNV Loss 21882294

Variation tolerance for IL16 Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.19; 87.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL16 Gene

HapMap Linkage Disequilibrium report
IL16
Human Gene Mutation Database (HGMD)
IL16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL16 Gene

Disorders for IL16 Gene

MalaCards: The human disease database

(9) MalaCards diseases for IL16 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
whipple disease
  • whipple's disease
whiplash
vasomotor rhinitis
  • rhinitis vasomotor
inclusion conjunctivitis
  • inclusion blenorrhea
viral meningitis
  • meningitis viral
- elite association
Search IL16 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL16

Genetic Association Database (GAD)
IL16
Human Genome Epidemiology (HuGE) Navigator
IL16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL16
genes like me logo Genes that share disorders with IL16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL16 Gene

Publications for IL16 Gene

  1. Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor. (PMID: 9144227) Baier M. … Kurth R. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 23 67
  2. Cytokine expression in placenta-derived mesenchymal stem cells in patients with pre-eclampsia and normal pregnancies. (PMID: 19819721) Hwang J.H. … Oh M.J. (Cytokine 2010) 23 67
  3. Transforming growth factor beta1 and laminin-111 cooperate in the induction of interleukin-16 expression in synovial fibroblasts from patients with rheumatoid arthritis. (PMID: 19279017) Warstat K. … Aicher W.K. (Ann. Rheum. Dis. 2010) 23 67
  4. Immune activation in advanced cancer patients treated with recombinant IL-21: multianalyte profiling of serum proteins. (PMID: 18925392) Dodds M.G. … Hughes S.D. (Cancer Immunol. Immunother. 2009) 23 67
  5. IL-12 p40 homodimer, but not IL-12 p70, induces the expression of IL-16 in microglia and macrophages. (PMID: 19100623) Jana M. … Pahan K. (Mol. Immunol. 2009) 23 67

Products for IL16 Gene

Sources for IL16 Gene

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