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Aliases for IL16 Gene

Aliases for IL16 Gene

  • Interleukin 16 2 3
  • Lymphocyte Chemoattractant Factor 2 3
  • Prointerleukin 16 2 3
  • LCF 3 6
  • Interleukin 16 (Lymphocyte Chemoattractant Factor) 2
  • Neuronal Interleukin 16 3
  • Pro-Interleukin-16 3
  • PrIL-16 3
  • PRIL16 3
  • NIL16 3

External Ids for IL16 Gene

Summaries for IL16 Gene

Entrez Gene Summary for IL16 Gene

  • The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

GeneCards Summary for IL16 Gene

IL16 (Interleukin 16) is a Protein Coding gene. Diseases associated with IL16 include whiplash and vasomotor rhinitis. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity. An important paralog of this gene is PARD3B.

UniProtKB/Swiss-Prot for IL16 Gene

  • Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4

  • Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane

  • Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells

Gene Wiki entry for IL16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL16 Gene

Genomics for IL16 Gene

Genomic Location for IL16 Gene

Start:
81,159,575 bp from pter
End:
81,314,058 bp from pter
Size:
154,484 bases
Orientation:
Plus strand

Genomic View for IL16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL16 Gene

Regulatory Elements for IL16 Gene

Proteins for IL16 Gene

  • Protein details for IL16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14005-IL16_HUMAN
    Recommended name:
    Pro-interleukin-16
    Protein Accession:
    Q14005
    Secondary Accessions:
    • A6NM20
    • A8MU65
    • B5TY35
    • B9EGR6
    • H3BVH5
    • Q16435
    • Q6VVE6
    • Q6ZMQ7
    • Q9UP18

    Protein attributes for IL16 Gene

    Size:
    1332 amino acids
    Molecular mass:
    141752 Da
    Quaternary structure:
    • Homotetramer (Probable). According to PubMed:9699630, the formation of a homotetrameric protein complex is not required for the chemo-attractant function. Isoform 3 interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Isoform 1 interacts with PPP1R12B. Isoform 3 interacts with GRIN2A. Isoform 3 interacts with GABPB1. Isoform 3 interacts (via PDZ 3 domain) with HDAC3. Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and CACNA1C (By similarity). Isoform 3 interacts with HTLV-1 tax.

    Three dimensional structures from OCA and Proteopedia for IL16 Gene

    Alternative splice isoforms for IL16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL16 Gene

Proteomics data for IL16 Gene at MOPED

Post-translational modifications for IL16 Gene

  • Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IL16 Gene

Domains for IL16 Gene

Gene Families for IL16 Gene

HGNC:
  • IL :Interleukins and interleukin receptors

Protein Domains for IL16 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

IL16_HUMAN
Domain:
  • Contains 4 PDZ (DHR) domains.:
    • Q14005
genes like me logo Genes that share domains with IL16: view

Function for IL16 Gene

Molecular function for IL16 Gene

GENATLAS Biochemistry: interleukin 16,T cell derived cytokine,lymphocyte chemoattractant factor,inducing the chemotactic and immunomodulatory responses of ED4+ lymphocytes monocytes and eosinophils
UniProtKB/Swiss-Prot Function: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4
UniProtKB/Swiss-Prot Function: Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane
UniProtKB/Swiss-Prot Function: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells
UniProtKB/Swiss-Prot Induction: Isoform 3 is down-regulated in T-cells after TCR activation.

Gene Ontology (GO) - Molecular Function for IL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IL16: view
genes like me logo Genes that share phenotypes with IL16: view

Animal Models for IL16 Gene

MGI Knock Outs for IL16:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IL16 Gene

Localization for IL16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL16 Gene

Interleukin-16: Secreted.
Isoform 1: Cytoplasm.
Isoform 3: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL16 Gene COMPARTMENTS Subcellular localization image for IL16 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 4
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for IL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with IL16: view

Pathways for IL16 Gene

genes like me logo Genes that share pathways with IL16: view

Pathways by source for IL16 Gene

Gene Ontology (GO) - Biological Process for IL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006955 immune response TAS 9144227
GO:0016032 viral process IEA --
GO:0030595 leukocyte chemotaxis IEA --
genes like me logo Genes that share ontologies with IL16: view

Compounds for IL16 Gene

(18) Novoseek inferred chemical compound relationships for IL16 Gene

Compound -log(P) Hits PubMed IDs
il 16 92 17
rantes 81.2 64
histamine 16.7 11
fluticasone propionate 12.1 2
ccl4 9.93 1
genes like me logo Genes that share compounds with IL16: view

Transcripts for IL16 Gene

Unigene Clusters for IL16 Gene

Interleukin 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL16 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d · 14e · 14f ^ 15 ^ 16a · 16b · 16c ^
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 17a · 17b · 17c · 17d · 17e ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b · 22c ^ 23a · 23b · 23c
SP1:
SP2:
SP3: - -
SP4: -
SP5: - -
SP6: -
SP7: -
SP8:
SP9:
SP10: - -
SP11:
SP12:

Relevant External Links for IL16 Gene

GeneLoc Exon Structure for
IL16
ECgene alternative splicing isoforms for
IL16

Expression for IL16 Gene

mRNA expression in normal human tissues for IL16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL16 Gene

This gene is overexpressed in Whole Blood (10.2), Brain - Cerebellar Hemisphere (4.5), and Brain - Cerebellum (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IL16 Gene

SOURCE GeneReport for Unigene cluster for IL16 Gene Hs.459095

mRNA Expression by UniProt/SwissProt for IL16 Gene

Q14005-IL16_HUMAN
Tissue specificity: Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation
genes like me logo Genes that share expressions with IL16: view

Orthologs for IL16 Gene

This gene was present in the common ancestor of animals.

Orthologs for IL16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL16 36
  • 99.35 (n)
  • 99.32 (a)
IL16 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL16 36
  • 82.02 (n)
  • 77.69 (a)
IL16 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL16 36
  • 83.26 (n)
  • 81.85 (a)
IL16 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il16 36
  • 82.13 (n)
  • 81.5 (a)
Il16 16
Il16 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL16 37
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL16 37
  • 6 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il16 36
  • 82.08 (n)
  • 80.21 (a)
chicken
(Gallus gallus)
Aves IL16 36
  • 60.93 (n)
  • 57.07 (a)
IL16 37
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-5402 37
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il16 36
  • 56.5 (n)
  • 51.99 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01068274.1 37
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bbg 37
  • 10 (a)
OneToOne
Species with no ortholog for IL16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL16 Gene

ENSEMBL:
Gene Tree for IL16 (if available)
TreeFam:
Gene Tree for IL16 (if available)

Paralogs for IL16 Gene

Paralogs for IL16 Gene

genes like me logo Genes that share paralogs with IL16: view

Variants for IL16 Gene

Sequence variations from dbSNP and Humsavar for IL16 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs859 -- 81,308,981(+) CTAAA(A/G)TAAGG utr-variant-3-prime
rs1028 -- 81,308,968(+) CAAAA(A/G)GTTGT utr-variant-3-prime
rs11325 -- 81,308,999(+) CACAC(G/T)GGGGC utr-variant-3-prime
rs884819 -- 81,196,468(+) TTGAA(C/T)CCCCC upstream-variant-2KB, intron-variant
rs925272 -- 81,219,849(+) AAACA(C/T)TCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL16 Gene

Variant ID Type Subtype PubMed ID
nsv904436 CNV Loss 21882294

Relevant External Links for IL16 Gene

HapMap Linkage Disequilibrium report
IL16
Human Gene Mutation Database (HGMD)
IL16

Disorders for IL16 Gene

(49) Novoseek inferred disease relationships for IL16 Gene

Disease -log(P) Hits PubMed IDs
dermatitis atopic 52.4 26
asthma allergic 50.5 10
inflammation 49.8 42
asthma 46.1 45
graves disease 46 7

Relevant External Links for IL16

Genetic Association Database (GAD)
IL16
Human Genome Epidemiology (HuGE) Navigator
IL16
genes like me logo Genes that share disorders with IL16: view

No data available for UniProtKB/Swiss-Prot for IL16 Gene

Publications for IL16 Gene

  1. Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor. (PMID: 9144227) Baier M. … Kurth R. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 23
  2. Nuclear translocation of the N-terminal prodomain of interleukin- 16. (PMID: 11032842) Zhang Y. … Center D.M. (J. Biol. Chem. 2001) 3 4 23
  3. Association of allergic contact dermatitis with a promoter polymorphism in the IL16 gene. (PMID: 14657881) Reich K. … Schnuch A. (J. Allergy Clin. Immunol. 2003) 3 23 49
  4. A polymorphism in the promoter region of the human interleukin-16 gene is not associated with asthma or atopy in an Australian population. (PMID: 15784111) Akesson L.S. … Kedda M.A. (Clin. Exp. Allergy 2005) 3 23 49
  5. Allograft TNFbeta and IL16 polymorphisms influence HCV recurrence and severity after liver transplantation. (PMID: 16447204) Kimball P. … Fisher R.A. (Liver Transpl. 2006) 3 23 49

Products for IL16 Gene

Sources for IL16 Gene

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