IL15RA Gene
protein-coding GIFtS: 54
GCID: GC10M005991
|
|
interleukin 15 receptor, alpha
| |
Aliases
for IL15RA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Interleukin 15 Receptor, Alpha1 2 | | IL-15R-Alpha1 | | CD2151 2 | | CD215 Antigen3 | | IL-15RA1 3 | | IL-15 Receptor Subunit Alpha3 | | Interleukin-15 Receptor Subunit Alpha2 | | |
| External Ids: | HGNC: 59781 | Entrez Gene: 36012 | Ensembl: ENSG000001344707 | OMIM: 6010705 | UniProtKB: Q132613 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n409288 | |
Export aliases for IL15RA gene to outside databasesPrevious GC identifers: GC10M005938 GC10M006141 GC10M005998 GC10M006034 GC10M005921
Summaries
for IL15RA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IL15RA:
This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptorsof IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biologicalactivities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additionalIL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor isreported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiplealternatively spliced transcript variants of this gene have been reported.(provided by RefSeq, Apr 2010)
UniProtKB/Swiss-Prot: I15RA_HUMAN, Q13261Function: High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset ofcells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interferewith signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involvesSTAT3, STAT5, STAT6, JAK2 (By similarity) and SYK
Gene Wiki entry for IL15RA (Interleukin 15 receptor, alpha subunit)
|
Genomic Views
for IL15RA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IL15RA gene promoter:
ISGF-3 MAZR Nkx2-5 IRF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for IL15RA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL15RA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p15.1 Ensembl cytogenetic band: 10p15.1 HGNC cytogenetic band: 10p15.1IL15RA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M005991: view genomic region
(about GC identifiers)
Start:
|
5,991,038 bp from pter |
End:
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6,020,150 bp from pter |
Size:
|
29,113 bases |
Orientation:
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minus strand |
|
Proteins
for IL15RA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: I15RA_HUMAN, Q13261 (See
protein sequence)Recommended Name: Interleukin-15 receptor subunit alpha precursor Size: 267 amino acids; 28233 Da
Subunit: The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates(By similarity). Interacts with SYK
Subcellular location: Membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membraneprotein. Note=Mainly found associated with the nuclear membrane
Subcellular location: Isoform 5: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatusmembrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein.Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated withendoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane
Subcellular location: Isoform 6: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatusmembrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein.Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated withendoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane
Subcellular location: Isoform 7: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatusmembrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein.Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated withendoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane
Subcellular location: Isoform 8: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatusmembrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein.Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated withendoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane
Subcellular location: Soluble interleukin-15 receptor subunit alpha: Secreted, extracellular space
Sequence caution: Sequence=AAB88175.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAI41080.1; Type=Erroneous gene model prediction; Sequence=EAW86419.1; Type=Erroneous gene model prediction;
4 PDB 3D structures from  and Proteopedia  for IL15RA:2ERS (3D)
2Z3Q (3D)
2Z3R (3D)
4GS7 (3D)
Secondary accessions: B4E2C2 Q5JVA1 Q5JVA2 Q5JVA4 Q6B0J2 Q7LDR4 Q7Z609Alternative splicing: 8 isoforms: Q13261-1 Q13261-3 Q13261-4 Q13261-5 Q13261-6 Q13261-7 Q13261-8 Q13261-9 Explore the universe of human proteins at neXtProt for IL15RA: NX_Q13261
Post-translational modifications:
A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage involvesADAM17/TACE (By similarity). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor1
Phosphorylated by activated SYK1
N-glycosylated and O-glycosylated1
View neXtProt modification sites for NX_Q13261
IL15RA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001230468.1 NP_001243694.1 NP_002180.1 NP_751950.2
ENSEMBL proteins: ENSP00000393612 ENSP00000380423 ENSP00000369312 ENSP00000435454 ENSP00000405128 ENSP00000432691 ENSP00000380422 ENSP00000369306 ENSP00000435995 ENSP00000380426 ENSP00000431529 ENSP00000380420 ENSP00000395113 ENSP00000405107 ENSP00000380421
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
IL15RA for ontologies About GeneDecksing
IL15RA Antibody Products:
Assay Products for IL15RA: |
Protein
Domains /
Families
for IL15RA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IL15RA for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q13261ProtoNet protein and cluster: Q13261 1 Blocks protein family: IPB000436 Sushi domain/SCR domain/CCP module
UniProtKB/Swiss-Prot: I15RA_HUMAN, Q13261Similarity: Contains 1 Sushi (CCP/SCR) domain |
Function
for IL15RA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: I15RA_HUMAN, Q13261Function: High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset ofcells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interferewith signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involvesSTAT3, STAT5, STAT6, JAK2 (By similarity) and SYK Genatlas biochemistry entry for IL15RA:interleukin 15,receptor,alpha chain,ubiquitously expressed
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL15RA (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL15RA (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): IL15RA (NM_002189) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL15RA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL15RA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL15RA |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
IL15RA for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for IL15RA: Il15ratm1.1Nsl Il15ratm1Nsl Il15ratm1Ama
4 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Il15ra):
IL15RA for phenotypes About GeneDecksing
|
Pathways & Interactions
for IL15RA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Akt Signaling | | | 2 | PEDF Induced Signaling | | | 3 | IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types | | | 4 | Jak-STAT signaling pathway | | | 5 | IL-9 Signaling Pathways | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  R&D Systems Pathways for IL15RA
5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL15RA (see all 7)
1  BioSystems Pathway for IL15RA
3 
Kegg Pathways (Kegg details for IL15RA):
IL15RA for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IL15RA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/27 Interacting proteins for IL15RA (Q132611, 3 ENSP000003693124) via UniProtKB, MINT, STRING, and/or I2D (see all 27)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
IL15RA for ontologies About GeneDecksing
|
Drugs & Compounds
for IL15RA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IL15RA
Search CenterWatch for drugs/clinical trials and news about IL15RA / I15RA
|
Transcripts
for IL15RA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IL15RA gene (4 alternative transcripts): NM_001243539.1 NM_001256765.1 NM_002189.3 NM_172200.2 Unigene Cluster for IL15RA: Interleukin 15 receptor, alpha Hs.445124 [show with all ESTs]Unigene Representative Sequence: AK12501418/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000435171 ENST00000397251 ENST00000379977 ENST00000534292(uc001iiw.3)
ENST00000532948 ENST00000379972(uc001iiy.3) ENST00000528354 ENST00000447291
ENST00000379974 ENST00000532039 ENST00000397250 ENST00000379971 ENST00000530685
ENST00000397255 ENST00000525219 ENST00000397246 ENST00000429135 ENST00000453922
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL15RA (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL15RA (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): IL15RA (NM_002189) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL15RA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL15RA |
Additional cDNA sequence: AF035279.1 AK125014.1 AK304211.1 BC065506.1 BC074726.2 BC107777.1 BC121140.2 BC121141.2 CR457064.1 CR542023.1 HQ401283.1 JX987304.1 JX987305.1 JX987306.1 JX987307.1 JX987308.1 JX987309.1 JX987310.1 JX987311.1 NR_046362.1 U31628.1 14 DOTS entries: DT.100747951 DT.92419404 DT.92419403 DT.121218248 DT.95157968 DT.121245726 DT.70102425 DT.92419402 DT.92419405 DT.95337046 DT.97843503 DT.99935675 DT.95150595 DT.97784567 24/89 AceView cDNA sequences (see all 89): AI559787 BM771217 BM771846 BM760165 AI589822 BQ271671 BM771295 AF035279 CR607367 CR609337 NM_002189 BM771826 NM_172200 BM754745 U31628 BM129138 AI956173 BG675498 BI836961 BM752051 N93504 BM740031 BX399036 BC074726
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for IL15RA (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for IL15RA
|
Expression
for IL15RA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IL15RA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACAGGGACC
About this image
See IL15RA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL15RA
SOURCE GeneReport for Unigene cluster: Hs.445124
UniProtKB/Swiss-Prot: I15RA_HUMAN, Q13261Tissue specificity: Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 arewidely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex andthalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brainstructures
SABiosciences Expression via Pathway-Focused PCR Array including IL15RA: | Inflammatory Response & Autoimmunity 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL15RA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL15RA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL15RA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL15RA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL15RA |
Orthologs
for IL15RA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for IL15RA gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Il15ra1 , 5 |
interleukin 15 receptor, alpha chain1, 5 |
70.05(n)1
55.08(a)1 |
|
2 (8.97 cM)5
161691 NM_008358.11 NP_032384.11
117052875 |
ENSEMBL Gene Tree for IL15RA (if available)
TreeFam Gene Tree for IL15RA (if available) |
Paralogs
for IL15RA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IL15RA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IL15RA (5991038 - 6020150 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for IL15RA
2 CNVs: 48006 48007 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL15RA |
|
Disorders
/ Diseases
for IL15RA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IL15RA for disorders About GeneDecksing
OMIM gene information: 601070
OMIM disorders: --
20/32  diseases for IL15RA (see all 32): About MalaCardsdiffuse large b-cell lymphoma b-cell lymphomas systemic lupus erythematosus eosinophilic esophagitis
aplastic anemia lupus erythematosus inflammatory bowel disease acute lymphoblastic leukemia
lymphoblastic leukemia bronchiolitis cblc rheumatoid arthritis
lung cancer hepatitis b anemia pulmonary disease
gingivitis t-cell leukemia leukemia alzheimer's disease
3 Novoseek disease relationships for IL15RA gene About this table
Human Genome Epidemiology (HuGE) Navigator: IL15RA (21 documents)
Export disorders for IL15RA gene to outside databases
|
Publications
for IL15RA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IL15RA gene, integrated from 9 sources (see all 133):
(articles sorted by number of sources associating them with IL15RA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. (PubMed id 8530383)1, 2, 3, 9 Anderson D.M.... Cosman D. (1995)
- Natural splicing of exon 2 of human interleukin-15 receptor alpha- chain mRNA results in a shortened form with a distinct pattern of expression. (PubMed id 10480910)1, 2, 9 Dubois S.... Jacques Y. (1999)
- Identification of an interleukin-15alpha receptor-binding site on human interleukin-15. (PubMed id 15039446)1, 2, 9 Bernard J.... Jacques Y. (2004)
- The structure of the interleukin-15 alpha receptor and its implications for ligand binding. (PubMed id 16377614)1, 2, 9 Lorenzen I.... Grotzinger J. (2006)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist. (PubMed id 15265897)1, 2 Mortier E.... Jacques Y. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Expression of IL-15 and IL-15 receptor isoforms in select structures of human fetal brain. (PubMed id 12114302)1, 2 Kurowska M.... Maslinski W. (2002)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 2 Yu W.... Gibbs R.A. (1997)
- IL-15/IL-15Ralpha intracellular trafficking in human melanoma cells and signal transduction through the IL-15Ralpha. (PubMed id 11064452)1, 9 Pereno R....Azzarone B. (2000)
|
External Searches for IL15RA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IL15RA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IL15RA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IL15RA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for IL15RA | Pharmacogenomics, SNPs, Pathways | | SeattleSNPs | http://pga.gs.washington.edu/data/il15ra/ |
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About This Section
| Patent Information for IL15RA gene:
Search GeneIP for patents involving IL15RA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for IL15RA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IL15RA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL15RA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL15RA | | | OriGene Protein Over-expression Lysate for IL15RA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IL15RA | | OriGene 3'-UTR Clone for IL15RA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL15RA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL15RA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IL15RA | | OriGene Custom Protein Services for IL15RA | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL15RA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL15RA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL15RA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL15RA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL15RA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL15RA |
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| | | | Search Tocris compounds for IL15RA |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL15RA |
|  |  |  | | | | Search ThermoFisher Antibodies for IL15RA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL15RA |
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Last full update: 18 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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