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Aliases for IL15RA Gene

Aliases for IL15RA Gene

  • Interleukin 15 Receptor Subunit Alpha 2 3 5
  • Interleukin 15 Receptor, Alpha 2 3
  • Interleukin 15 Receptor Alpha Isoform EM2 3
  • Interleukin 15 Receptor Alpha Isoform IC2 3
  • Interleukin 15 Receptor Alpha Isoform IC3 3
  • Interleukin 15 Receptor Alpha Isoform IC4 3
  • Interleukin 15 Receptor Alpha Isoform IC5 3
  • Interleukin 15 Receptor Alpha Isoform IC6 3
  • Interleukin 15 Receptor Alpha Isoform IC7 3
  • Interleukin 15 Receptor Alpha Isoform IC8 3
  • Interleukin-15 Receptor Subunit Alpha 3
  • IL-15 Receptor Subunit Alpha 4
  • CD215 Antigen 4
  • IL-15R-Alpha 4
  • IL-15RA 4
  • CD215 3

External Ids for IL15RA Gene

Previous GeneCards Identifiers for IL15RA Gene

  • GC10M005938
  • GC10M006141
  • GC10M005998
  • GC10M006034
  • GC10M005921

Summaries for IL15RA Gene

Entrez Gene Summary for IL15RA Gene

  • This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]

GeneCards Summary for IL15RA Gene

IL15RA (Interleukin 15 Receptor Subunit Alpha) is a Protein Coding gene. Among its related pathways are IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and Innate Immune System. GO annotations related to this gene include signal transducer activity and cytokine receptor activity.

UniProtKB/Swiss-Prot for IL15RA Gene

  • High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK.

Gene Wiki entry for IL15RA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL15RA Gene

Genomics for IL15RA Gene

Regulatory Elements for IL15RA Gene

Enhancers for IL15RA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G005941 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.7 +34.3 34310 6.3 HDGF PKNOX1 ATF1 CREB3L1 ARNT YY1 TCF12 ZNF121 ZNF766 GATA2 IL15RA LOC105376384 IL2RA GDI2 PFKFB3 ANKRD16 CALML3-AS1 PIR38458
GH10G005974 1.7 FANTOM5 ENCODE dbSUPER 17.8 +2.2 2199 4.5 HDGF PKNOX1 ARNT CREB3L1 SIN3A YBX1 ZNF2 ZBTB7B ZNF143 FOS IL15RA PFKFB3 LOC105376384 NRBF2P5 RBM17 GC10P005977
GH10G006033 1.5 FANTOM5 Ensembl ENCODE 15.8 -55.5 -55473 0.6 HDAC1 PKNOX1 ATF1 TBL1XR1 ARNT ZBTB40 ZNF766 NCOA1 ZEB2 ELF1 PFKFB3 IL15RA LOC105376384 FBXO18 RBM17 ENSG00000229664 GC10M006043 GC10M006044
GH10G005950 1.3 Ensembl ENCODE dbSUPER 18.1 +27.4 27418 2.2 CBX3 ZNF76 MAX CEBPG RAD21 YY1 ZNF155 ZNF324 CBX5 PATZ1 LOC105376384 IL15RA IL2RA ENSG00000226647 PFKFB3 GDI2 GC10P005977
GH10G006193 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12 -217.3 -217265 4.2 FOXA2 SIN3A ZBTB7B TCF12 ZNF121 ZNF766 GATA2 FOS JUNB SREBF1 PFKFB3 IL15RA LOC399715 ENSG00000213994 GC10M006147
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL15RA on UCSC Golden Path with GeneCards custom track

Promoters for IL15RA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000023916 1334 2201 HDGF PKNOX1 ARNT CREB3L1 SIN3A YBX1 ZNF2 ZBTB7B ZNF302 FOS

Genomic Location for IL15RA Gene

Chromosome:
10
Start:
5,943,639 bp from pter
End:
5,978,634 bp from pter
Size:
34,996 bases
Orientation:
Minus strand

Genomic View for IL15RA Gene

Genes around IL15RA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL15RA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL15RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL15RA Gene

Proteins for IL15RA Gene

  • Protein details for IL15RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13261-I15RA_HUMAN
    Recommended name:
    Interleukin-15 receptor subunit alpha
    Protein Accession:
    Q13261
    Secondary Accessions:
    • B4E2C2
    • Q3B769
    • Q5JVA1
    • Q5JVA2
    • Q5JVA4
    • Q6B0J2
    • Q7LDR4
    • Q7Z609

    Protein attributes for IL15RA Gene

    Size:
    267 amino acids
    Molecular mass:
    28233 Da
    Quaternary structure:
    • The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates (By similarity). Interacts with SYK.
    SequenceCaution:
    • Sequence=AAB88175.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI41080.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW86419.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL15RA Gene

    Alternative splice isoforms for IL15RA Gene

neXtProt entry for IL15RA Gene

Post-translational modifications for IL15RA Gene

  • A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage involves ADAM17/TACE (By similarity). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor.
  • N-glycosylated and O-glycosylated.
  • Phosphorylated by activated SYK.
  • Glycosylation at posLast=137137

Antibody Products

  • R&D Systems Antibodies for IL15RA (IL-15 R alpha)
  • Abcam antibodies for IL15RA

No data available for DME Specific Peptides for IL15RA Gene

Domains & Families for IL15RA Gene

Protein Domains for IL15RA Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IL15RA: view

No data available for UniProtKB/Swiss-Prot for IL15RA Gene

Function for IL15RA Gene

Molecular function for IL15RA Gene

GENATLAS Biochemistry:
interleukin 15,receptor,alpha chain,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK.

Gene Ontology (GO) - Molecular Function for IL15RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 7641685
GO:0004896 cytokine receptor activity TAS 7641685
GO:0005515 protein binding IPI 16284400
genes like me logo Genes that share ontologies with IL15RA: view
genes like me logo Genes that share phenotypes with IL15RA: view

Animal Models for IL15RA Gene

MGI Knock Outs for IL15RA:

Animal Model Products

CRISPR Products

miRNA for IL15RA Gene

miRTarBase miRNAs that target IL15RA

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL15RA Gene

Localization for IL15RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL15RA Gene

Membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Note=Mainly found associated with the nuclear membrane.
Isoform 5: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Isoform 6: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Isoform 7: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Isoform 8: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Soluble interleukin-15 receptor subunit alpha: Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL15RA gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
golgi apparatus 5
nucleus 3
cytosol 2
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IL15RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with IL15RA: view

Pathways & Interactions for IL15RA Gene

genes like me logo Genes that share pathways with IL15RA: view

SIGNOR curated interactions for IL15RA Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL15RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8530383
GO:0007259 JAK-STAT cascade IEA --
GO:0008283 cell proliferation TAS 8530383
GO:0010977 negative regulation of neuron projection development IEA --
GO:0019221 cytokine-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with IL15RA: view

Transcripts for IL15RA Gene

Unigene Clusters for IL15RA Gene

Interleukin 15 receptor, alpha:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL15RA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - -

Relevant External Links for IL15RA Gene

GeneLoc Exon Structure for
IL15RA
ECgene alternative splicing isoforms for
IL15RA

Expression for IL15RA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL15RA Gene

Protein differential expression in normal tissues from HIPED for IL15RA Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL15RA Gene



Protein tissue co-expression partners for IL15RA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IL15RA Gene:

IL15RA

SOURCE GeneReport for Unigene cluster for IL15RA Gene:

Hs.445124

mRNA Expression by UniProt/SwissProt for IL15RA Gene:

Q13261-I15RA_HUMAN
Tissue specificity: Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.

Evidence on tissue expression from TISSUES for IL15RA Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with IL15RA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL15RA Gene

Orthologs for IL15RA Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL15RA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL15RA 34 35
  • 98.96 (n)
dog
(Canis familiaris)
Mammalia IL15RA 34 35
  • 72.32 (n)
rat
(Rattus norvegicus)
Mammalia Il15ra 34
  • 71.28 (n)
mouse
(Mus musculus)
Mammalia Il15ra 34 16 35
  • 70.85 (n)
cow
(Bos Taurus)
Mammalia IL15RA 34 35
  • 69.41 (n)
oppossum
(Monodelphis domestica)
Mammalia IL15RA 35
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL15RA 35
  • 28 (a)
OneToOne
Species where no ortholog for IL15RA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL15RA Gene

ENSEMBL:
Gene Tree for IL15RA (if available)
TreeFam:
Gene Tree for IL15RA (if available)

Paralogs for IL15RA Gene

(1) SIMAP similar genes for IL15RA Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with IL15RA: view

No data available for Paralogs for IL15RA Gene

Variants for IL15RA Gene

Sequence variations from dbSNP and Humsavar for IL15RA Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000010444 -- 5,964,224(+) TGTGA(C/T)CACAA intron-variant, nc-transcript-variant
rs1000018148 -- 5,958,290(+) ATATG(C/T)TTATT intron-variant, upstream-variant-2KB
rs1000085300 -- 5,963,908(+) GAACG(A/G)GATAC intron-variant
rs1000270987 -- 5,969,484(+) CTTTC(C/T)ACCTC intron-variant, upstream-variant-2KB
rs1000369290 -- 5,958,535(+) CATGT(A/G)CCACC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IL15RA Gene

Variant ID Type Subtype PubMed ID
dgv1e49 CNV loss 18971310
dgv666n100 CNV gain 25217958
nsv519436 CNV loss 19592680
nsv549907 CNV loss 21841781
nsv549908 CNV loss 21841781
nsv549909 CNV loss 21841781
nsv831775 CNV loss 17160897
nsv975792 CNV duplication 23825009

Variation tolerance for IL15RA Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL15RA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL15RA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL15RA Gene

Disorders for IL15RA Gene

Relevant External Links for IL15RA

Genetic Association Database (GAD)
IL15RA
Human Genome Epidemiology (HuGE) Navigator
IL15RA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL15RA

No disorders were found for IL15RA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IL15RA Gene

Publications for IL15RA Gene

  1. Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. (PMID: 8530383) Anderson D.M. … Cosman D. (J. Biol. Chem. 1995) 2 3 4 22 64
  2. Role of interleukin-15 receptor alpha polymorphisms in normal weight obese syndrome. (PMID: 19309557) Di Renzo L. … De Lorenzo A. (Int J Immunopathol Pharmacol 2009) 3 22 46 64
  3. Interleukin-15 and interleukin-15R alpha SNPs and associations with muscle, bone, and predictors of the metabolic syndrome. (PMID: 18514540) Pistilli E.E. … Hoffman E.P. (Cytokine 2008) 3 22 46 64
  4. The structure of the interleukin-15 alpha receptor and its implications for ligand binding. (PMID: 16377614) Lorenzen I. … Grotzinger J. (J. Biol. Chem. 2006) 3 4 22 64
  5. Normal Weight Obese syndrome: role of single nucleotide polymorphism of IL-1 5Ralpha and MTHFR 677C-->T genes in the relationship between body composition and resting metabolic rate. (PMID: 17121316) Di Renzo L. … De Lorenzo A. (Eur Rev Med Pharmacol Sci 2006) 3 22 46 64

Products for IL15RA Gene

Sources for IL15RA Gene

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