Aliases for IL15RA Gene
- Interleukin 15 Receptor Subunit Alpha 2 3 5
- Interleukin 15 Receptor, Alpha 2 3
- Interleukin 15 Receptor Alpha Isoform EM2 3
- Interleukin 15 Receptor Alpha Isoform IC2 3
- Interleukin 15 Receptor Alpha Isoform IC3 3
- Interleukin 15 Receptor Alpha Isoform IC4 3
- Interleukin 15 Receptor Alpha Isoform IC5 3
- Interleukin 15 Receptor Alpha Isoform IC6 3
External Ids for IL15RA Gene
Previous GeneCards Identifiers for IL15RA Gene
This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]
GeneCards Summary for IL15RA Gene
IL15RA (Interleukin 15 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL15RA include large granular lymphocyte leukemia. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include signal transducer activity and cytokine receptor activity.
UniProtKB/Swiss-Prot for IL15RA Gene
High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK.