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IL15RA Gene

protein-coding   GIFtS: 59
GCID: GC10M005991

Interleukin 15 Receptor, Alpha

  See IL15RA-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Interleukin 15 Receptor, Alpha1 2     Interleukin 15 Receptor Alpha Isoform IC72
CD2152     Interleukin 15 Receptor Alpha Isoform IC82
Interleukin 15 Receptor Alpha Isoform EM22     Interleukin-15 Receptor Subunit Alpha2
Interleukin 15 Receptor Alpha Isoform IC22     IL-15R-alpha3
Interleukin 15 Receptor Alpha Isoform IC32     IL-15RA3
Interleukin 15 Receptor Alpha Isoform IC42     CD215 Antigen3
Interleukin 15 Receptor Alpha Isoform IC52     IL-15 Receptor Subunit Alpha3
Interleukin 15 Receptor Alpha Isoform IC62     

External Ids:    HGNC: 59781   Entrez Gene: 36012   Ensembl: ENSG000001344707   OMIM: 6010705   UniProtKB: Q132613   
ORGUL members:         

Export aliases for IL15RA gene to outside databases

Previous GC identifers: GC10M005938 GC10M006141 GC10M005998 GC10M006034 GC10M005921


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL15RA Gene:
This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The
receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping
biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an
additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of
binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and
IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL
and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.(provided by RefSeq,
Apr 2010)

GeneCards Summary for IL15RA Gene:
IL15RA (interleukin 15 receptor, alpha) is a protein-coding gene. Diseases associated with IL15RA include t-cell large granular lymphocyte leukemia. GO annotations related to this gene include cytokine receptor activity and signal transducer activity.

UniProtKB/Swiss-Prot: I15RA_HUMAN, Q13261
Function: High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset
of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or
interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal
transduction involves SYK

Gene Wiki entry for IL15RA (Interleukin 15 receptor, alpha subunit) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL15RA gene promoter:
         ISGF-3   MAZR   Nkx2-5   IRF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL15RA promoter sequence
   Search Chromatin IP Primers for IL15RA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL15RA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.1   Ensembl cytogenetic band:  10p15.1   HGNC cytogenetic band: 10p15.1

IL15RA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL15RA gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M005991:  view genomic region     (about GC identifiers)

Start:
5,990,855 bp from pter      End:
6,020,150 bp from pter
Size:
29,296 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: I15RA_HUMAN, Q13261 (See protein sequence)
Recommended Name: Interleukin-15 receptor subunit alpha precursor  
Size: 267 amino acids; 28233 Da
Subunit: The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also
self-associates (By similarity). Interacts with SYK
Sequence caution: Sequence=AAB88175.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAI41080.1; Type=Erroneous gene model prediction; Sequence=EAW86419.1; Type=Erroneous gene model
prediction;
4 PDB 3D structures from and Proteopedia for IL15RA:
2ERS (3D)        2Z3Q (3D)        2Z3R (3D)        4GS7 (3D)    
Secondary accessions: B4E2C2 Q5JVA1 Q5JVA2 Q5JVA4 Q6B0J2 Q7LDR4 Q7Z609
Alternative splicing: 8 isoforms:  Q13261-1   Q13261-3   Q13261-4   Q13261-5   Q13261-6   Q13261-7   Q13261-8   Q13261-9   

Explore the universe of human proteins at neXtProt for IL15RA: NX_Q13261

Explore proteomics data for IL15RA at MOPED

Post-translational modifications: 

  • A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage
    involves ADAM17/TACE (By similarity). It also binds IL-15 and thus interferes with IL-15 binding to the membrane
    receptor1
  • Phosphorylated by activated SYK1
  • N-glycosylated and O-glycosylated1
  • Glycosylation2 at Asn137

  • See IL15RA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001230468.1  NP_001243694.1  NP_002180.1  NP_751950.2  

    ENSEMBL proteins: 
     ENSP00000393612   ENSP00000369312   ENSP00000435454   ENSP00000405128   ENSP00000432691  
     ENSP00000380422   ENSP00000369306   ENSP00000435995   ENSP00000380426   ENSP00000380420  
     ENSP00000395113   ENSP00000405107   ENSP00000380423   ENSP00000380421   ENSP00000431529  

    IL15RA Human Recombinant Protein Products:

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    antibodies-online peptides for IL15RA

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 15 receptor, alpha subunit
    IL-2 receptor family

    1 InterPro protein domain:
     IPR000436 Sushi_SCR_CCP

    Graphical View of Domain Structure for InterPro Entry Q13261

    ProtoNet protein and cluster: Q13261

    1 Blocks protein domain: IPB000436 Sushi domain/SCR domain/CCP module

    UniProtKB/Swiss-Prot: I15RA_HUMAN, Q13261
    Similarity: Contains 1 Sushi (CCP/SCR) domain


    Find genes that share domains with IL15RA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I15RA_HUMAN, Q13261
    Function: High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset
    of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or
    interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal
    transduction involves SYK

         Genatlas biochemistry entry for IL15RA:
    interleukin 15,receptor,alpha chain,ubiquitously expressed

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS7641685
    GO:0004896cytokine receptor activity TAS7641685
    GO:0005515protein binding IPI16284400
         
    Find genes that share ontologies with IL15RA           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Il15ra):
     cellular  hematopoietic system  immune system  normal 

    Find genes that share phenotypes with IL15RA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IL15RA: Il15ratm1.1Nsl Il15ratm1Nsl Il15ratm1Ama

       genOway: Develop your customized and physiologically relevant rodent model for IL15RA

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    SwitchGear 3'UTR luciferase reporter plasmidIL15RA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IL15RA

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    GenScript: all cDNA clones in your preferred vector (see all 2): IL15RA (NM_002189)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    I15RA_HUMAN, Q13261: Membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane
    protein. Note=Mainly found associated with the nuclear membrane
    I15RA_HUMAN, Q13261: Isoform 5: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi
    apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I
    membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform
    8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane
    I15RA_HUMAN, Q13261: Isoform 6: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi
    apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I
    membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform
    8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane
    I15RA_HUMAN, Q13261: Isoform 7: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi
    apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I
    membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform
    8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane
    I15RA_HUMAN, Q13261: Isoform 8: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi
    apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I
    membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform
    8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane
    I15RA_HUMAN, Q13261: Soluble interleukin-15 receptor subunit alpha: Secreted, extracellular space
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular5
    golgi apparatus5
    nucleus5
    cytosol1
    lysosome1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005615extracellular space IEA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with IL15RA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL15RA About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    2Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    3IL-9 Signaling Pathways
    IL-15 Signaling Pathways0.88
    4TGF-Beta Pathway
    MAPK Family Pathway0.60
    5PAK Pathway
    Antioxidant Action of Vitamin-C0.56


    Find genes that share SuperPaths with IL15RA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IL15RA
        IL-15 Signaling Pathways
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL15RA (see all 7)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling
    Akt Signaling

    1 BioSystems Pathway for IL15RA
        TCR Signaling Pathway



    4 Kegg Pathways  (Kegg details for IL15RA):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    Intestinal immune network for IgA production
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Array including IL15RA: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IL15RA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL15RA (Q132611, 3 ENSP000003693124) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL15P409331, 3, ENSP000002965454EBI-980354,EBI-980274 I2D: score=4 STRING: ENSP00000296545
    SYKP434053, ENSP000003648984I2D: score=3 STRING: ENSP00000364898
    IL2RBP147843, ENSP000002162234I2D: score=2 STRING: ENSP00000216223
    AXLP305303, ENSP000003011784I2D: score=2 STRING: ENSP00000301178
    TRAF2Q129333, ENSP000002476684I2D: score=4 STRING: ENSP00000247668
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8530383
    GO:0007259JAK-STAT cascade IEA--
    GO:0008283cell proliferation TAS8530383
    GO:0010977negative regulation of neuron projection development IEA--
    GO:0019221cytokine-mediated signaling pathway TAS7641685

    Find genes that share ontologies with IL15RA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for IL15RA (I15RA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL15RA gene (4 alternative transcripts): 
    NM_001243539.1  NM_001256765.1  NM_002189.3  NM_172200.2  

    Unigene Cluster for IL15RA:

    Interleukin 15 receptor, alpha
    Hs.445124  [show with all ESTs]
    Unigene Representative Sequence: AK125014
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000435171 ENST00000379977 ENST00000534292(uc001iiw.3) ENST00000532948
    ENST00000379972(uc001iiy.3) ENST00000528354 ENST00000447291 ENST00000379974
    ENST00000532039 ENST00000397250 ENST00000379971 ENST00000530685 ENST00000397255
    ENST00000397246 ENST00000429135 ENST00000453922 ENST00000397251 ENST00000397248(uc001iiv.3 uc010qau.2 uc021pmo.1 uc021pmp.1)

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    SwitchGear 3'UTR luciferase reporter plasmidIL15RA 3' UTR sequence
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    Additional mRNA sequence: 

    AF035279.1 AK125014.1 AK304211.1 BC065506.1 BC074726.2 BC107777.1 BC121140.2 BC121141.2 
    CR457064.1 CR542023.1 HQ401283.1 JX987304.1 JX987305.1 JX987306.1 JX987307.1 JX987308.1 
    JX987309.1 JX987310.1 JX987311.1 NR_046362.1 U31628.1 

    14 DOTS entries:

    DT.100747951  DT.92419404  DT.92419403  DT.121218248  DT.95157968  DT.121245726  DT.70102425  DT.92419402 
    DT.92419405  DT.95337046  DT.97843503  DT.99935675  DT.95150595  DT.97784567 

    Selected AceView cDNA sequences (see all 89):

    BM771846 U31628 CR607367 BM754745 NM_002189 NM_172200 BM771826 BQ271671 
    BM771217 AI559787 BM760165 AF035279 AI589822 BM129138 BM771295 CR609337 
    AK125014 BM747363 CR457064 BQ941044 AA872259 BM739003 BX385240 BG206140 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IL15RA (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d
    SP1:                          -     -     -     -     -     -                                         -                     
    SP2:                                            -     -     -                                         -                     
    SP3:                          -     -     -     -     -     -     -     -                             -                     
    SP4:                          -     -     -     -                       -                                                   
    SP5:                                            -     -     -     -     -                             -                     


    ECgene alternative splicing isoforms for IL15RA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL15RA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAGGGACC
    IL15RA Expression
    About this image

    IL15RA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL15RA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445124

    UniProtKB/Swiss-Prot: I15RA_HUMAN, Q13261
    Tissue specificity: Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are
    widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in
    cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in
    all brain structures

        Pathway & Disease-focused RT2 Profiler PCR Array including IL15RA: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for IL15RA gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il15ra1 , 5 interleukin 15 receptor, alpha chain1, 5 70.85(n)1
    57.14(a)1
      2 (8.97 cM)5
    161691  NM_008358.21  NP_032384.11 
     117052875 


    ENSEMBL Gene Tree for IL15RA (if available)
    TreeFam Gene Tree for IL15RA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL15RA gene
    1 SIMAP similar gene for IL15RA using alignment to 10 protein entries:     I15RA_HUMAN (see all proteins):
    il15ra

    Find genes that share paralogs with IL15RA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL15RA (see all 714)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1931815491,2
    --5993866(+) AATCCC/TCCTGC 5 -- ds50010--------
    rs1430799091,2
    --5994067(+) AAACAC/GCAAAG 5 -- ds50010--------
    rs31366321,2
    H--5994113(-) CCCAGT/GGGTAT 5 -- ds50014Minor allele frequency- G:0.00NS EA 418
    rs1844705801,2
    --5994432(+) GACAAA/GGAAGT 5 -- ut31 nc-transcript-variant0--------
    rs1896206411,2
    --5994517(+) GATTCG/TCTGGG 5 -- ut31 nc-transcript-variant0--------
    rs108541,2
    C,H--5994532(-) GGGAGA/GGATGC 5 -- ut31 nc-transcript-variantese39Minor allele frequency- G:0.00MN EA NS 886
    rs81777491,2
    C,F--5994553(-) GGACAG/CGGACC 5 -- ut31 nc-transcript-variantese32Minor allele frequency- C:0.01NS 92
    rs81777471,2
    C--5994628(-) CGTGG-/TCAA  
      TTACAA
    GAGAC
    5 -- ut31 nc-transcript-variant2Minor allele frequency- TCAATTACAA:0.01NS 92
    rs22961351,2
    C,F,O,A,H--5994694(+) AACTGA/CAAGTT 5 -- ut31 nc-transcript-variant44Minor allele frequency- N:0.00EA NA MN NS WA CSA 5564
    rs81777451,2
    C,F,H--5994833(-) CCTTGG/AACCCA 5 -- ut31 nc-transcript-variantese38Minor allele frequency- A:0.02NS NA WA 904

    HapMap Linkage Disequilibrium report for IL15RA (5990855 - 6020150 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for IL15RA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519436CNV Loss19592680
    dgv1e49CNV Loss18971310
    dgv603n71CNV Loss21882294
    nsv831775CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601070    OMIM disorders: --

    1 disease for IL15RA:    
    About MalaCards
    t-cell large granular lymphocyte leukemia


    Find genes that share disorders with IL15RA           About GenesLikeMe

    3 Novoseek inferred disease relationships for IL15RA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 6.06 4 11810184 (1), 19821081 (1), 18483276 (1), 18523252 (1)
    inflammation 2.57 1 17979156 (1)
    necrosis 0 1 19821081 (1)

    Genetic Association Database (GAD): IL15RA
    Human Genome Epidemiology (HuGE) Navigator: IL15RA (21 documents)

    Export disorders for IL15RA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL15RA gene, integrated from 10 sources (see all 146):
    (articles sorted by number of sources associating them with IL15RA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. (PubMed id 8530383)1, 2, 3, 9 Anderson D.M.... Cosman D. (J. Biol. Chem. 1995)
    2. Natural splicing of exon 2 of human interleukin-15 receptor alpha- chain mRNA results in a shortened form with a distinct pattern of expression. (PubMed id 10480910)1, 2, 9 Dubois S.... Jacques Y. (J. Biol. Chem. 1999)
    3. Identification of an interleukin-15alpha receptor-binding site on human interleukin-15. (PubMed id 15039446)1, 2, 9 Bernard J.... Jacques Y. (J. Biol. Chem. 2004)
    4. The structure of the interleukin-15 alpha receptor and its implications for ligand binding. (PubMed id 16377614)1, 2, 9 Lorenzen I.... Grotzinger J. (J. Biol. Chem. 2006)
    5. Normal Weight Obese syndrome: role of single nucleotide polymorphism of IL-1 5Ralpha and MTHFR 677C--&gt;T genes in the relationship between body composition and resting metabolic rate. (PubMed id 17121316)1, 4, 9 Di Renzo L....De Lorenzo A. (Eur Rev Med Pharmacol Sci 2006)
    6. Role of interleukin-15 receptor alpha polymorphisms in normal weight obese syndrome. (PubMed id 19309557)1, 4, 9 Di Renzo L....De Lorenzo A. (Int J Immunopathol Pharmacol 2009)
    7. Interleukin-15 and interleukin-15R alpha SNPs and associations with muscle, bone, and predictors of the metabolic syndrome. (PubMed id 18514540)1, 4, 9 Pistilli E.E....Hoffman E.P. (Cytokine 2008)
    8. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    9. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    10. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3601 HGNC: 5978 AceView: IL15RA Ensembl:ENSG00000134470 euGenes: HUgn3601
    ECgene: IL15RA Kegg: 3601 H-InvDB: IL15RA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL15RA Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/il15ra/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL15RA gene:
    Search GeneIP for patents involving IL15RA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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