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Aliases for IL15RA Gene

Aliases for IL15RA Gene

  • Interleukin 15 Receptor, Alpha 2 3
  • Interleukin 15 Receptor Alpha Isoform EM2 3
  • Interleukin 15 Receptor Alpha Isoform IC2 3
  • Interleukin 15 Receptor Alpha Isoform IC3 3
  • Interleukin 15 Receptor Alpha Isoform IC4 3
  • Interleukin 15 Receptor Alpha Isoform IC5 3
  • Interleukin 15 Receptor Alpha Isoform IC6 3
  • Interleukin 15 Receptor Alpha Isoform IC7 3
  • Interleukin 15 Receptor Alpha Isoform IC8 3
  • Interleukin-15 Receptor Subunit Alpha 3
  • IL-15 Receptor Subunit Alpha 4
  • CD215 Antigen 4
  • IL-15R-Alpha 4
  • IL-15RA 4
  • CD215 3

External Ids for IL15RA Gene

Previous GeneCards Identifiers for IL15RA Gene

  • GC10M005938
  • GC10M006141
  • GC10M005998
  • GC10M006034
  • GC10M005921

Summaries for IL15RA Gene

Entrez Gene Summary for IL15RA Gene

  • This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]

GeneCards Summary for IL15RA Gene

IL15RA (Interleukin 15 Receptor, Alpha) is a Protein Coding gene. Diseases associated with IL15RA include t-cell large granular lymphocyte leukemia. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include signal transducer activity and cytokine receptor activity.

UniProtKB/Swiss-Prot for IL15RA Gene

  • High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK.

Gene Wiki entry for IL15RA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL15RA Gene

Genomics for IL15RA Gene

Regulatory Elements for IL15RA Gene

Genomic Location for IL15RA Gene

Start:
5,937,569 bp from pter
End:
5,978,578 bp from pter
Size:
41,010 bases
Orientation:
Minus strand

Genomic View for IL15RA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL15RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL15RA Gene

Proteins for IL15RA Gene

  • Protein details for IL15RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13261-I15RA_HUMAN
    Recommended name:
    Interleukin-15 receptor subunit alpha
    Protein Accession:
    Q13261
    Secondary Accessions:
    • B4E2C2
    • Q3B769
    • Q5JVA1
    • Q5JVA2
    • Q5JVA4
    • Q6B0J2
    • Q7LDR4
    • Q7Z609

    Protein attributes for IL15RA Gene

    Size:
    267 amino acids
    Molecular mass:
    28233 Da
    Quaternary structure:
    • The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates (By similarity). Interacts with SYK.
    SequenceCaution:
    • Sequence=AAB88175.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI41080.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW86419.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL15RA Gene

    Alternative splice isoforms for IL15RA Gene

neXtProt entry for IL15RA Gene

Proteomics data for IL15RA Gene at MOPED

Post-translational modifications for IL15RA Gene

  • A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage involves ADAM17/TACE (By similarity). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor.
  • N-glycosylated and O-glycosylated.
  • Phosphorylated by activated SYK.
  • Glycosylation at Asn137

Antibody Products

  • R&D Systems Antibodies for IL15RA (IL-15 R alpha)

No data available for DME Specific Peptides for IL15RA Gene

Domains for IL15RA Gene

Gene Families for IL15RA Gene

HGNC:
  • CD :CD molecules
  • IL :Interleukins and interleukin receptors
IUPHAR :

Protein Domains for IL15RA Gene

Graphical View of Domain Structure for InterPro Entry

Q13261

UniProtKB/Swiss-Prot:

I15RA_HUMAN :
  • Q13261
Domain:
  • Contains 1 Sushi (CCP/SCR) domain.
genes like me logo Genes that share domains with IL15RA: view

Function for IL15RA Gene

Molecular function for IL15RA Gene

GENATLAS Biochemistry: interleukin 15,receptor,alpha chain,ubiquitously expressed
UniProtKB/Swiss-Prot Function: High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK.

Gene Ontology (GO) - Molecular Function for IL15RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 7641685
GO:0004896 cytokine receptor activity TAS 7641685
GO:0005515 protein binding IPI 16284400
genes like me logo Genes that share ontologies with IL15RA: view
genes like me logo Genes that share phenotypes with IL15RA: view

Animal Models for IL15RA Gene

MGI Knock Outs for IL15RA:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IL15RA Gene

Localization for IL15RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL15RA Gene

Membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Note=Mainly found associated with the nuclear membrane.
Isoform 5: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Isoform 6: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Isoform 7: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Isoform 8: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Soluble interleukin-15 receptor subunit alpha: Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL15RA Gene COMPARTMENTS Subcellular localization image for IL15RA gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 5
nucleus 5
cytosol 1
lysosome 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IL15RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
GO:0005634 nucleus --
GO:0005783 endoplasmic reticulum --
genes like me logo Genes that share ontologies with IL15RA: view

Pathways for IL15RA Gene

genes like me logo Genes that share pathways with IL15RA: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for IL15RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8530383
GO:0007259 JAK-STAT cascade --
GO:0008283 cell proliferation TAS 8530383
GO:0010977 negative regulation of neuron projection development --
GO:0019221 cytokine-mediated signaling pathway TAS 7641685
genes like me logo Genes that share ontologies with IL15RA: view

Transcripts for IL15RA Gene

Unigene Clusters for IL15RA Gene

Interleukin 15 receptor, alpha:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL15RA

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL15RA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - -

Relevant External Links for IL15RA Gene

GeneLoc Exon Structure for
IL15RA
ECgene alternative splicing isoforms for
IL15RA

Expression for IL15RA Gene

mRNA expression in normal human tissues for IL15RA Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL15RA Gene

SOURCE GeneReport for Unigene cluster for IL15RA Gene Hs.445124

mRNA Expression by UniProt/SwissProt for IL15RA Gene

Q13261-I15RA_HUMAN
Tissue specificity: Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.
genes like me logo Genes that share expressions with IL15RA: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for IL15RA Gene

Orthologs for IL15RA Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL15RA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL15RA 35
  • 98.96 (n)
  • 97.17 (a)
IL15RA 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL15RA 35
  • 69.41 (n)
  • 54.55 (a)
IL15RA 36
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL15RA 35
  • 72.32 (n)
  • 59.75 (a)
IL15RA 36
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il15ra 35
  • 70.85 (n)
  • 57.14 (a)
Il15ra 16
Il15ra 36
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL15RA 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL15RA 36
  • 28 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il15ra 35
  • 71.28 (n)
  • 57.14 (a)
Species with no ortholog for IL15RA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL15RA Gene

ENSEMBL:
Gene Tree for IL15RA (if available)
TreeFam:
Gene Tree for IL15RA (if available)

Paralogs for IL15RA Gene

Selected SIMAP similar genes for IL15RA Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with IL15RA: view

No data available for Paralogs for IL15RA Gene

Variants for IL15RA Gene

Sequence variations from dbSNP and Humsavar for IL15RA Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs10854 -- 5,952,569(-) GGGAG(A/G)GATGC utr-variant-3-prime, nc-transcript-variant
rs767951 -- 5,978,391(+) GTGCA(C/G)ATTCT upstream-variant-2KB, reference, missense
rs1323649 -- 5,970,859(+) GGCCT(C/T)AAGCA intron-variant
rs1977263 -- 5,975,713(+) acatg(A/G)tgaaa intron-variant
rs2146930 -- 5,958,028(-) AAGAA(C/T)ATCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL15RA Gene

Variant ID Type Subtype PubMed ID
dgv1e49 CNV Loss 18971310
nsv831775 CNV Loss 17160897
nsv519436 CNV Loss 19592680
dgv603n71 CNV Loss 21882294

Relevant External Links for IL15RA Gene

HapMap Linkage Disequilibrium report
IL15RA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL15RA Gene

Disorders for IL15RA Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for IL15RA Gene including...

Search for IL15RA Gene in MalaCards »

(3) Novoseek inferred disease relationships for IL15RA Gene

Disease -log(P) Hits PubMed IDs
tumors 6.06 4
inflammation 2.57 1
necrosis 0 1

Relevant External Links for IL15RA

Genetic Association Database (GAD)
IL15RA
Human Genome Epidemiology (HuGE) Navigator
IL15RA
genes like me logo Genes that share disorders with IL15RA: view

No data available for UniProtKB/Swiss-Prot for IL15RA Gene

Publications for IL15RA Gene

  1. Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. (PMID: 8530383) Anderson D.M. … Cosman D. (J. Biol. Chem. 1995) 2 3 4 23
  2. Natural splicing of exon 2 of human interleukin-15 receptor alpha- chain mRNA results in a shortened form with a distinct pattern of expression. (PMID: 10480910) Dubois S. … Jacques Y. (J. Biol. Chem. 1999) 3 4 23
  3. Identification of an interleukin-15alpha receptor-binding site on human interleukin-15. (PMID: 15039446) Bernard J. … Jacques Y. (J. Biol. Chem. 2004) 3 4 23
  4. The structure of the interleukin-15 alpha receptor and its implications for ligand binding. (PMID: 16377614) Lorenzen I. … Grotzinger J. (J. Biol. Chem. 2006) 3 4 23
  5. Normal Weight Obese syndrome: role of single nucleotide polymorphism of IL-1 5Ralpha and MTHFR 677C-->T genes in the relationship between body composition and resting metabolic rate. (PMID: 17121316) Di Renzo L. … De Lorenzo A. (Eur Rev Med Pharmacol Sci 2006) 3 23 48

Products for IL15RA Gene

Sources for IL15RA Gene

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