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IL15 Gene

protein-coding   GIFtS: 63
GCID: GC04P142557

Interleukin 15

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 151 2
IL-152 3
interleukin-152

External Ids:    HGNC: 59771   Entrez Gene: 36002   Ensembl: ENSG000001641367   OMIM: 6005545   UniProtKB: P409333   

Export aliases for IL15 gene to outside databases

Previous GC identifers: GC04P143420 GC04P142875 GC04P143023 GC04P143135 GC04P142915 GC04P138287


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL15 Gene:
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and
proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common
hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's
activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2.
This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of
transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine
may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation
activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been
reported. (provided by RefSeq, Feb 2011)

GeneCards Summary for IL15 Gene:
IL15 (interleukin 15) is a protein-coding gene. Diseases associated with IL15 include gamma chain deficiency, and rasmussen encephalitis. GO annotations related to this gene include cytokine receptor binding and cytokine activity.

UniProtKB/Swiss-Prot: IL15_HUMAN, P40933
Function: Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction
of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha

Gene Wiki entry for IL15 (Interleukin 15) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL15 gene promoter:
         GR   ISGF-3   STAT3   GR-alpha   STAT5A   AP-2gamma   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL15 promoter sequence
   Search Chromatin IP Primers for IL15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31   Ensembl cytogenetic band:  4q31.21   HGNC cytogenetic band: 4q31

IL15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL15 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P142557:  view genomic region     (about GC identifiers)

Start:
142,557,749 bp from pter      End:
142,655,140 bp from pter
Size:
97,392 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL15_HUMAN, P40933 (See protein sequence)
Recommended Name: Interleukin-15 precursor  
Size: 162 amino acids; 18086 Da
Sequence caution: Sequence=CAA71044.1; Type=Miscellaneous discrepancy; Note=Man-made cDNA construct with a
sequence coding for signal peptide increasing the secretion of the protein (substitution with a signal peptide
derived from the mouse IgV kappa chain);
4 PDB 3D structures from and Proteopedia for IL15:
2XQB (3D)        2Z3Q (3D)        2Z3R (3D)        4GS7 (3D)    
Secondary accessions: D3DNZ2 O00440 O43512 Q495Z8 Q93058 Q9UBA3
Alternative splicing: 2 isoforms:  P40933-1   P40933-2   

Explore the universe of human proteins at neXtProt for IL15: NX_P40933

Post-translational modifications: 

  • Glycosylation2 at Asn127
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins (2 alternative transcripts): 
    NP_000576.1  NP_751915.1  

    ENSEMBL proteins: 
     ENSP00000323505   ENSP00000296545   ENSP00000422271   ENSP00000435462   ENSP00000436914  
     ENSP00000377714  

    IL15 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant IL15 Protein
    R&D Systems Recombinant & Natural Proteins for IL15 (IL-15)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for IL15
    OriGene Protein Over-expression Lysate for IL15
    OriGene MassSpec for IL15
    OriGene Custom Protein Services for IL15
    GenScript Purified and Recombinant Proteins for IL15
    Novus Biologicals IL15 Proteins
    Novus Biologicals IL15 Lysates
    Sino Biological Recombinant Protein for IL15
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for IL15
    Cloud-Clone Corp. Proteins for IL15

    IL15 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL15
    R&D Systems Antibodies for IL15 (IL-15)
    OriGene Antibodies for IL15
    OriGene Custom Antibody Services for IL15
    Novus Biologicals IL15 Antibodies
    Abcam antibodies for IL15
    Cloud-Clone Corp. Antibodies for IL15
    ThermoFisher Antibody for IL15
    LSBio Antibodies in human, mouse, rat for IL15

    IL15 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL15
    R&D Systems Flow Cytometry Kits for IL15 (IL-15)         (see all)
    GenScript Custom Assay Services for IL15
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL15
    Cloud-Clone Corp. CLIAs for IL15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    4 InterPro protein domains:
     IPR009079 4_helix_cytokine-like_core
     IPR003443 IL-15/IL-21_fam
     IPR020466 IL-15_mml
     IPR020439 IL-15

    Graphical View of Domain Structure for InterPro Entry P40933

    ProtoNet protein and cluster: P40933

    1 Blocks protein domain: IPB003443 Interleukin 15

    UniProtKB/Swiss-Prot: IL15_HUMAN, P40933
    Similarity: Belongs to the IL-15/IL-21 family


    IL15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL15_HUMAN, P40933
    Function: Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction
    of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha

         Genatlas biochemistry entry for IL15:
    interleukin 15,structurally and functionally related to IL2,involved in the differentiation of natural killer
    cells

         Summary: 
    IL15 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
                
    Blood: Natural killer-like cells, Natural killer-like cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005126cytokine receptor binding IEA--
    GO:0005515protein binding IPI16284400
         
    IL15 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Il15):
     cardiovascular system  embryogenesis  growth/size/body  hematopoietic system  immune system 
     mortality/aging  reproductive system 

    IL15 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Il15tm1Imx for IL15

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL15
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL15
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL15

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL15:
    hsa-mir-215-5p (MIRT024918), hsa-mir-192-5p (MIRT026532)

    Block miRNA regulation of human, mouse, rat IL15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL15 (see all 19):
    hsa-miR-640 hsa-miR-376b hsa-miR-4272 hsa-miR-15a hsa-miR-4263 hsa-miR-944 hsa-miR-3074-3p hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidIL15 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL15
    Predesigned siRNA for gene silencing in human, mouse, rat IL15

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL15

    Clone
    Products:
         
    OriGene clones in human, mouse for IL15 (see all 9)
    OriGene ORF clones in mouse, rat for IL15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IL15 (NM_000585)
    Sino Biological Human cDNA Clone for IL15
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL15

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IL15
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL15 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL15_HUMAN, P40933: Isoform IL15-S48AA: Secreted
    IL15_HUMAN, P40933: Isoform IL15-S21AA: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is
    stored intracellularly, appearing in the nucleus and cytoplasmic components
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus5
    endosome4
    golgi apparatus4
    plasma membrane4
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    IL15 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL15 About   (see all 15)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    MAPK Family Pathway0.60
    SOCS Pathway0.40
    JAK-STAT Pathway0.57
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    5IL-9 Signaling Pathways
    IL-15 Signaling Pathways0.88

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IL15
        IL-15 Signaling Pathways
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL15 (see all 25)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling

    1 BioSystems Pathway for IL15
        Cytokines and Inflammatory Response



    Selected Kegg Pathways  (Kegg details for IL15) (see all 7):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    TNF signaling pathway
    Intestinal immune network for IgA production
    HTLV-I infection


    IL15 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL15 (see all 15): 
              NFKB Signaling Targets in human mouse rat
              Antiviral Response in human mouse rat
              Leukemia in human mouse rat
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for IL15 (P409331, 3 ENSP000002965454) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL15RAQ132611, 3, ENSP000003693124EBI-980274,EBI-980354 I2D: score=4 STRING: ENSP00000369312
    IL2RBP147843, ENSP000002162234I2D: score=3 STRING: ENSP00000216223
    IL2RGP317853I2D: score=2 
    IGHG1ENSP000003749904STRING: ENSP00000374990
    IGLC2ENSP000003748564STRING: ENSP00000374856
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001779natural killer cell differentiation IEA--
    GO:0001866NK T cell proliferation IEA--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS8178155

    IL15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL15

    Selected Novoseek inferred chemical compound relationships for IL15 gene (see all 72)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 70.1 58 11274230 (4), 17986095 (4), 18492658 (3), 11746532 (3) (see all 41)
    il-12 52.5 13 19698229 (5), 12850791 (1), 16471244 (1), 16024007 (1)
    gliadin 46.1 11 20153259 (3), 11040186 (1), 17100768 (1), 12853196 (1) (see all 8)
    alpha-galactosylceramide 45.9 14 10715513 (4), 11150537 (3), 17312126 (1), 12960313 (1) (see all 5)
    blys 43.4 1 16920570 (1)
    gm-csf 42.5 4 12494899 (1), 17082320 (1), 12893770 (1)
    ccl3 39 1 17170049 (1)
    il 10 38.8 6 9743948 (3), 10641032 (1), 19505916 (1), 20083555 (1)
    poly(i-c) 38.3 4 12960048 (1), 15196204 (1), 16299289 (1)
    gluten 33.1 9 17100768 (4), 18667914 (1), 15925843 (1), 16728270 (1) (see all 5)



    IL15 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IL15 gene (3 alternative transcripts): 
    NM_000585.4  NM_172175.2  NM_172174.2  

    Unigene Cluster for IL15:

    Interleukin 15
    Hs.168132  [show with all ESTs]
    Unigene Representative Sequence: NR_037840
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000320650 ENST00000296545(uc010iol.3 uc003iis.3 uc003iit.3)
    ENST00000514653 ENST00000529613 ENST00000477265 ENST00000505351 ENST00000509249
    ENST00000394159
    miRNA
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    Block miRNA regulation of human, mouse, rat IL15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL15 (see all 19):
    hsa-miR-640 hsa-miR-376b hsa-miR-4272 hsa-miR-15a hsa-miR-4263 hsa-miR-944 hsa-miR-3074-3p hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidIL15 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IL15
    Predesigned siRNA for gene silencing in human, mouse, rat IL15
    Clone
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    OriGene clones in human, mouse for IL15 (see all 9)
    OriGene ORF clones in mouse, rat for IL15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IL15 (NM_000585)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL15
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IL15
    OriGene qSTAR qPCR primer pairs in human, mouse for IL15
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL15
      QuantiTect SYBR Green Assays in human, mouse, rat IL15
      QuantiFast Probe-based Assays in human, mouse, rat IL15

    Additional mRNA sequence: 

    AF031167.1 AK290619.1 AY720442.1 BC018149.2 BC100961.1 BC100962.1 BC100963.1 CR541980.1 
    CR542007.1 NR_037840.2 U14407.1 X94222.1 X94223.1 Z38000.1 

    6 DOTS entries:

    DT.75161076  DT.455390  DT.100747304  DT.100675458  DT.121276333  DT.100747305 

    Selected AceView cDNA sequences (see all 68):

    CR541980 CR617455 CR542007 AA897685 CR617480 BE870325 BM848565 AI656394 
    BX504391 AW418813 BX116580 X94223 AA973334 NM_172174 NM_172175 AI471945 
    BF108998 AI719764 AI379606 AK122993 U14407 X94222 AL548180 AI708379 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IL15 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
    SP1:                          -     -     -     -                       -     -                                       
    SP2:              -           -     -     -     -                       -     -                                       
    SP3:                                                                    -                                             
    SP4:                          -           -     -     -                 -     -                                       
    SP5:              -                       -     -                                                                     


    ECgene alternative splicing isoforms for IL15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACAGTAGA
    IL15 Expression
    About this image


    IL15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     NULL (Uncategorized)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Testis (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad
    IL15 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.168132

    UniProtKB/Swiss-Prot: IL15_HUMAN, P40933
    Tissue specificity: Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver
    and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL15 (see all 15): 
              NFKB Signaling Targets in human mouse rat
              Antiviral Response in human mouse rat
              Leukemia in human mouse rat
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IL15
    OriGene qSTAR qPCR primer pairs in human, mouse for IL15
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL15
    QuantiTect SYBR Green Assays in human, mouse, rat IL15
    QuantiFast Probe-based Assays in human, mouse, rat IL15
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL15 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il151 , 5 interleukin 151, 5 80.45(n)1
    72.84(a)1
      8 (39.33 cM)5
    161681  NM_008357.21  NP_032383.11 
     823316245 
    chicken
    (Gallus gallus)
    Aves IL156
    interleukin 15
    35(a)
    1 ↔ 1
    4(29463073-29495702)
    lizard
    (Anolis carolinensis)
    Reptilia IL156
    interleukin 15
    26(a)
    1 ↔ 1
    5(119295130-119308201)


    ENSEMBL Gene Tree for IL15 (if available)
    TreeFam Gene Tree for IL15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL15 (see all 1735)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58625411,2
    C--138329529(+) GTTGA-/T/TT  
            
    TTTTT
    3 -- int1 trp32NA 4
    rs1408572651,2
    --142340712(+) TTTATA/GTATCA 3 -- us2k10--------
    rs1421664441,2
    C--142340811(+) GCCTT-/AAAGTT 3 -- us2k10--------
    rs1441401641,2
    C--142340940(+) AGTCC-/TGCAGA 3 -- us2k10--------
    rs1145664471,2
    F--142341104(+) CTGAGC/TGTGGA 3 -- us2k11Minor allele frequency- T:0.03WA 118
    rs799824021,2
    C,F--142341126(+) TTCACC/TGGCTG 3 -- us2k11Minor allele frequency- T:0.05WA 118
    rs781878241,2
    F--142341314(+) TTGTGG/ATGAGA 3 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1447002041,2
    C--142341349(+) TCCCAA/GTGCAT 3 -- us2k10--------
    rs1478305511,2
    --142341358(+) ATGCTC/TATTCT 3 -- us2k10--------
    rs1396314811,2
    --142341458(+) CGTCAA/TGAACA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL15 (142557749 - 142655140 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IL15:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830094CNV Loss17160897
    nsv880172CNV Loss21882294
    nsv880173CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600554    OMIM disorders: --

    Selected diseases for IL15 (see all 164):    
    About MalaCards
    gamma chain deficiency    rasmussen encephalitis    microscopic colitis    large granular lymphocyte leukemia
    t-cell large granular lymphocyte leukemia    acute graft versus host disease    cardiac sarcoidosis    graft versus host disease
    scrub typhus    melioidosis    diabetic foot ulcers    severe combined immunodeficiency
    typhus    polymyositis    lymphopenia    radiculopathy
    celiac disease    sarcoidosis    mycosis fungoides    brucellosis

    1 disease from the University of Copenhagen DISEASES database for IL15:
    Rheumatoid arthritis

    IL15 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for IL15 gene (see all 89)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    severe combined immunodeficiency, x-linked 80.6 25 7632950 (3), 8026467 (1), 7803808 (1), 8605322 (1) (see all 17)
    necrosis 64.5 151 12878725 (2), 19967592 (2), 11817607 (2), 7523571 (1) (see all 99)
    rheumatoid arthritis 61.1 70 10679127 (5), 18557790 (2), 16362448 (2), 20007590 (2) (see all 52)
    tumors 54.4 242 7585540 (4), 11418694 (4), 14984938 (4), 19190330 (3) (see all 99)
    autoimmune diseases 54.1 26 11315928 (3), 12905728 (2), 16387851 (1), 19166383 (1) (see all 21)
    inflammation 53.7 71 15996196 (3), 15843549 (2), 19805228 (2), 11197599 (2) (see all 57)
    graft-versus-host disease 52.7 6 15976176 (2), 16860714 (1), 18641363 (1), 15280205 (1)
    celiac disease 47.3 21 12949719 (5), 17324400 (4), 11040186 (2), 19237603 (2) (see all 9)
    synovitis 43.4 14 17289161 (2), 12379638 (1), 16142748 (1), 12527218 (1) (see all 11)
    autoimmunity 42.5 5 17318811 (1), 18053164 (1), 18313361 (1), 18621751 (1) (see all 5)

    Genetic Association Database (GAD): IL15
    Human Genome Epidemiology (HuGE) Navigator: IL15 (49 documents)

    Export disorders for IL15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL15 gene, integrated from 10 sources (see all 1404):
    (articles sorted by number of sources associating them with IL15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. (PubMed id 8178155)1, 2, 3, 9 Grabstein K.H.... Giri J.G. (Science 1994)
    2. Influences of genetic variants in interleukin-15 gene and serum interleukin-15 levels on coronary heart disease. (PubMed id 19796965)1, 4, 9 Gokkusu C....Umman B. (Cytokine 2010)
    3. IL15 gene variants are not associated with asthma and atopy. (PubMed id 19133918)1, 4, 9 Pinto L.A....Kabesch M. (Allergy 2009)
    4. Molecular screening and association study of IL15 gene polymorphisms in rheumatoid arthritis. (PubMed id 17616399)1, 4, 9 Rueda B....Martin J. (Cytokine 2007)
    5. Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines. (PubMed id 8668345)1, 2, 9 Meazza R.... Ferrini S. (Oncogene 1996)
    6. Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women. (PubMed id 19505916)1, 4, 9 Van Dyke A.L....Schwartz A.G. (amp 2009)
    7. Polymorphisms in interleukin-15 gene on chromosome 4q31.2 are associated with psoriasis vulgaris in Chinese population. (PubMed id 17554368)1, 4, 9 Zhang X.J....Liu J.J. (J. Invest. Dermatol. 2007)
    8. The role of interleukin-15 polymorphisms in adult acute lymphoblastic leukemia. (PubMed id 21049047)1, 4 Lin D....Liu H. (PLoS ONE 2010)
    9. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (PLoS ONE 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3600 HGNC: 5977 AceView: IL15 Ensembl:ENSG00000164136 euGenes: HUgn3600
    ECgene: IL15 Kegg: 3600 H-InvDB: IL15

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL15 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL15 Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine source book: IL-15http://www.rndsystems.com/molecule_detail.aspx?m=1671
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_15

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL15 gene:
    Search GeneIP for patents involving IL15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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