Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IL15 Gene

Aliases for IL15 Gene

  • Interleukin 15 2 3 5
  • IL-15 3 4
  • Interleukin-15 3

External Ids for IL15 Gene

Previous GeneCards Identifiers for IL15 Gene

  • GC04P143420
  • GC04P142875
  • GC04P143023
  • GC04P143135
  • GC04P142915
  • GC04P142557
  • GC04P138287

Summaries for IL15 Gene

Entrez Gene Summary for IL15 Gene

  • The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]

GeneCards Summary for IL15 Gene

IL15 (Interleukin 15) is a Protein Coding gene. Diseases associated with IL15 include Rheumatoid Arthritis and Celiac Disease. Among its related pathways are Akt Signaling and PEDF Induced Signaling. GO annotations related to this gene include cytokine activity and cytokine receptor binding.

UniProtKB/Swiss-Prot for IL15 Gene

  • Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.

Gene Wiki entry for IL15 Gene

Additional gene information for IL15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL15 Gene

Genomics for IL15 Gene

Regulatory Elements for IL15 Gene

Enhancers for IL15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H141642 1.2 FANTOM5 Ensembl ENCODE 20.8 +6.9 6863 1 ZSCAN21 PKNOX1 PRDM6 JUND FOS IL15 ZNF330 GC04P141671
GH04H141349 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.9 -286.0 -285994 1 FOXA2 MAX RAD21 YY1 TCF7L2 STAT1 CEBPB NR3C1 REST EP300 LINC02432 IL15 ZNF330 ENSG00000250189
GH04H141328 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -306.9 -306935 3 HDAC1 TBP JUN MAX CEBPG RFX5 GATA3 POLR2A RCOR1 DEK LINC02432 IL15 ZNF330 ENSG00000248747
GH04H141639 0.6 FANTOM5 Ensembl 26 +3.8 3805 1 SPI1 IL15 ZNF330 GC04P141671
GH04H141686 1.2 Ensembl ENCODE 11.8 +50.3 50336 1 ZNF493 ZFP64 BRCA1 ZEB1 ZNF121 ZNF23 ZNF138 ZNF366 ZNF354C ZSCAN5C IL15 GC04P141671 GC04P142085
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL15 on UCSC Golden Path with GeneCards custom track

Promoters for IL15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000173988 404 2401 PKNOX1 TBL1XR1 SIN3A BATF GLIS2 ATF7 KLF7 ETV6 RUNX3 CREM

Genomic Location for IL15 Gene

Chromosome:
4
Start:
141,636,596 bp from pter
End:
141,733,987 bp from pter
Size:
97,392 bases
Orientation:
Plus strand

Genomic View for IL15 Gene

Genes around IL15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL15 Gene

Proteins for IL15 Gene

  • Protein details for IL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40933-IL15_HUMAN
    Recommended name:
    Interleukin-15
    Protein Accession:
    P40933
    Secondary Accessions:
    • D3DNZ2
    • O00440
    • O43512
    • Q495Z8
    • Q6FGX7
    • Q93058
    • Q9UBA3

    Protein attributes for IL15 Gene

    Size:
    162 amino acids
    Molecular mass:
    18086 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA71044.1; Type=Miscellaneous discrepancy; Note=Man-made cDNA with a signal peptide sequence to increase protein secretion (substitution with a signal peptide derived from the mouse IgV kappa chain).; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL15 Gene

    Alternative splice isoforms for IL15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL15 Gene

Post-translational modifications for IL15 Gene

  • Glycosylation at posLast=127127
  • Modification sites at PhosphoSitePlus

Other Protein References for IL15 Gene

Antibody Products

Assay Products

  • Cloud-Clone Corp. Assay Kits for IL15

No data available for DME Specific Peptides for IL15 Gene

Domains & Families for IL15 Gene

Gene Families for IL15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for IL15 Gene

Suggested Antigen Peptide Sequences for IL15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P40933

UniProtKB/Swiss-Prot:

IL15_HUMAN :
  • Belongs to the IL-15/IL-21 family.
Family:
  • Belongs to the IL-15/IL-21 family.
genes like me logo Genes that share domains with IL15: view

Function for IL15 Gene

Molecular function for IL15 Gene

GENATLAS Biochemistry:
interleukin 15,structurally and functionally related to IL2,involved in the differentiation of natural killer cells
UniProtKB/Swiss-Prot Function:
Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.

LifeMap Function Summary for IL15 Gene

IL15 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for IL15 Gene

Gene Ontology (GO) - Molecular Function for IL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005126 cytokine receptor binding IEA --
GO:0005515 protein binding IPI 16284400
genes like me logo Genes that share ontologies with IL15: view
genes like me logo Genes that share phenotypes with IL15: view

Animal Models for IL15 Gene

MGI Knock Outs for IL15:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IL15
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL15 Gene

Localization for IL15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL15 Gene

Isoform IL15-S48AA: Secreted.
Isoform IL15-S21AA: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL15 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
endosome 5
golgi apparatus 4
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS,IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 10851076
genes like me logo Genes that share ontologies with IL15: view

Pathways & Interactions for IL15 Gene

genes like me logo Genes that share pathways with IL15: view

SIGNOR curated interactions for IL15 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001779 natural killer cell differentiation IEA --
GO:0001866 NK T cell proliferation IEA --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA,TAS --
GO:0007165 signal transduction TAS 8178155
genes like me logo Genes that share ontologies with IL15: view

Drugs & Compounds for IL15 Gene

(38) Drugs for IL15 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AMG0714 Pharma 0

(35) Additional Compounds for IL15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL15: view

Transcripts for IL15 Gene

Unigene Clusters for IL15 Gene

Interleukin 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IL15
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IL15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
SP1: - - - - - -
SP2: - - - - - - -
SP3: -
SP4: - - - - - -
SP5: - - -
SP6:

Relevant External Links for IL15 Gene

GeneLoc Exon Structure for
IL15
ECgene alternative splicing isoforms for
IL15

Expression for IL15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of IL15 Gene:

IL15

SOURCE GeneReport for Unigene cluster for IL15 Gene:

Hs.168132

mRNA Expression by UniProt/SwissProt for IL15 Gene:

P40933-IL15_HUMAN
Tissue specificity: Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus.

Evidence on tissue expression from TISSUES for IL15 Gene

  • Bone marrow(4.5)
  • Intestine(4.5)
  • Skin(4.4)
  • Nervous system(4.4)
  • Heart(4.3)
  • Blood(3.1)
  • Lymph node(3)
  • Spleen(3)
  • Muscle(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with IL15: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL15 Gene

Orthologs for IL15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL15 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia IL15 33 34
  • 87.86 (n)
dog
(Canis familiaris)
Mammalia IL15 33 34
  • 84.16 (n)
mouse
(Mus musculus)
Mammalia Il15 33 16 34
  • 80.45 (n)
rat
(Rattus norvegicus)
Mammalia Il15 33
  • 79.84 (n)
oppossum
(Monodelphis domestica)
Mammalia IL15 34
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL15 34
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL15 34
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL15 34
  • 26 (a)
OneToOne
Species where no ortholog for IL15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL15 Gene

ENSEMBL:
Gene Tree for IL15 (if available)
TreeFam:
Gene Tree for IL15 (if available)

Paralogs for IL15 Gene

No data available for Paralogs for IL15 Gene

Variants for IL15 Gene

Sequence variations from dbSNP and Humsavar for IL15 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000087987 -- 141,679,672(+) AATAT(C/T)AAAAA intron-variant
rs1000098890 -- 141,697,142(+) TTTCA(A/G)CTCTT intron-variant
rs1000114336 -- 141,649,693(+) ATAAC(A/G)CAACA intron-variant
rs1000117832 -- 141,662,195(+) GCACC(C/T)TAGAG intron-variant
rs1000125541 -- 141,727,496(+) GAGGT(A/G)TGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL15 Gene

Variant ID Type Subtype PubMed ID
esv3564735 CNV deletion 23714750
nsv1018949 CNV gain 25217958
nsv830094 CNV loss 17160897

Variation tolerance for IL15 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL15 Gene

Disorders for IL15 Gene

MalaCards: The human disease database

(18) MalaCards diseases for IL15 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rheumatoid arthritis
  • rheumatoid arthritis, progression of
celiac disease
  • celiac sprue
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
severe combined immunodeficiency
  • combined t and b cell inborn immunodeficiency
jak3-deficient severe combined immunodeficiency
  • autosomal recessive t cell-negative, b cell-positive, nk cell-negative severe combined immunodeficiency
- elite association - COSMIC cancer census association via MalaCards
Search IL15 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL15

Genetic Association Database (GAD)
IL15
Human Genome Epidemiology (HuGE) Navigator
IL15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL15
genes like me logo Genes that share disorders with IL15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL15 Gene

Publications for IL15 Gene

  1. Influences of genetic variants in interleukin-15 gene and serum interleukin-15 levels on coronary heart disease. (PMID: 19796965) Gokkusu C … Umman B (Cytokine 2010) 3 22 45 60
  2. Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women. (PMID: 19505916) Van Dyke AL … Schwartz AG (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 22 45 60
  3. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. (PMID: 8178155) Grabstein KH … Ahdieh M (Science (New York, N.Y.) 1994) 2 3 4 60
  4. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 45 60
  5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 45 60

Products for IL15 Gene

Sources for IL15 Gene

Content
Loading form....