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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL15 Gene

protein-coding   GIFtS: 63
GCID: GC04P142557

Interleukin 15

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Interleukin 151 2
IL-152 3
interleukin-152

External Ids:    HGNC: 59771   Entrez Gene: 36002   Ensembl: ENSG000001641367   OMIM: 6005545   UniProtKB: P409333   
ORGUL members:         
NONCODE14:n410572      

Export aliases for IL15 gene to outside databases

Previous GC identifers: GC04P143420 GC04P142875 GC04P143023 GC04P143135 GC04P142915 GC04P138287


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL15 Gene:
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and
proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common
hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's
activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2.
This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of
transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine
may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation
activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been
reported. (provided by RefSeq, Feb 2011)

GeneCards Summary for IL15 Gene: 
IL15 (interleukin 15) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with IL15 include gamma chain deficiency, and rasmussen encephalitis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Regulation of eIF4 and p70S6K. GO annotations related to this gene include cytokine receptor binding and cytokine activity.

UniProtKB/Swiss-Prot: IL15_HUMAN, P40933
Function: Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction
of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha

Gene Wiki entry for IL15 (Interleukin 15) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL15 gene promoter:
         GR   ISGF-3   STAT3   GR-alpha   STAT5A   AP-2gamma   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL15 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31   Ensembl cytogenetic band:  4q31.21   HGNC cytogenetic band: 4q31

IL15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL15 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P142557:  view genomic region     (about GC identifiers)

Start:
142,557,749 bp from pter      End:
142,655,140 bp from pter
Size:
97,392 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL15_HUMAN, P40933 (See protein sequence)
Recommended Name: Interleukin-15 precursor  
Size: 162 amino acids; 18086 Da
Subcellular location: Isoform IL15-S48AA: Secreted
Subcellular location: Isoform IL15-S21AA: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is
stored intracellularly, appearing in the nucleus and cytoplasmic components
Sequence caution: Sequence=CAA71044.1; Type=Miscellaneous discrepancy; Note=Man-made cDNA construct with a
sequence coding for signal peptide increasing the secretion of the protein (substitution with a signal peptide
derived from the mouse IgV kappa chain);
4 PDB 3D structures from and Proteopedia for IL15:
2XQB (3D)        2Z3Q (3D)        2Z3R (3D)        4GS7 (3D)    
Secondary accessions: D3DNZ2 O00440 O43512 Q495Z8 Q93058 Q9UBA3
Alternative splicing: 2 isoforms:  P40933-1   P40933-2   

Explore the universe of human proteins at neXtProt for IL15: NX_P40933

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P40933

  • IL15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (2 alternative transcripts): 
    NP_000576.1  NP_751915.1  

    ENSEMBL proteins: 
     ENSP00000323505   ENSP00000296545   ENSP00000422271   ENSP00000435462   ENSP00000436914  
     ENSP00000377714  

    Human Recombinant Protein Products for IL15: 
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    Sino Biological Recombinant Protein for IL15
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for IL15
    Cloud-Clone Corp. Proteins for IL15 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm TAS10851076
    GO:0005768endosome TAS10851076

    IL15 for ontologies           About GeneDecksing



    IL15 Antibody Products: 
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    R&D Systems Antibodies for IL15 (IL-15)
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    Assay Products for IL15: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for IL15 
    Cloud-Clone Corp. CLIAs for IL15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IL: Interleukins and interleukin receptors

    3 InterPro protein domains:
     IPR020466 Interleukin-15_mammal
     IPR003443 Interleukin_15-like
     IPR020439 Interleukin-15

    Graphical View of Domain Structure for InterPro Entry P40933

    ProtoNet protein and cluster: P40933

    1 Blocks protein domain: IPB003443 Interleukin 15

    UniProtKB/Swiss-Prot: IL15_HUMAN, P40933
    Similarity: Belongs to the IL-15/IL-21 family


    IL15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL15_HUMAN, P40933
    Function: Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction
    of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha

         Genatlas biochemistry entry for IL15:
    interleukin 15,structurally and functionally related to IL2,involved in the differentiation of natural killer
    cells

         Summary:
    IL15 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Natural killer-like cells from Blood

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005126cytokine receptor binding IEA--
    GO:0005515protein binding IPI16284400
         
    IL15 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Il15):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     immune system  mortality/aging  reproductive system 

    IL15 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Il15tm1Imx for IL15

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL15 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL15 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL15 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidIL15 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of IL15 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL15


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL15 About   (see all 15)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    MAPK Family Pathway0.60
    SOCS Pathway0.40
    JAK-STAT Pathway0.57
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    5Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
    IL-15 Signaling Pathways0.88

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IL15
        IL-15 Signaling Pathways
    IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

    5/25 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL15 (see all 25)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling

    1 BioSystems Pathway for IL15
        Cytokines and Inflammatory Response



    5/7         Kegg Pathways  (Kegg details for IL15) (see all 7):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    TNF signaling pathway
    Intestinal immune network for IgA production
    HTLV-I infection


    IL15 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/19 Interacting proteins for IL15 (P409331, 3 ENSP000002965454) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL15RAQ132611, 3, ENSP000003693124EBI-980274,EBI-980354 I2D: score=4 STRING: ENSP00000369312
    IL2RBP147843, ENSP000002162234I2D: score=3 STRING: ENSP00000216223
    IL2RGP317853I2D: score=2 
    IGHG1ENSP000003749904STRING: ENSP00000374990
    IGLC2ENSP000003748564STRING: ENSP00000374856
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001779natural killer cell differentiation IEA--
    GO:0001866NK T cell proliferation IEA--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS8178155

    IL15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL15 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL15

    10/72 Novoseek inferred chemical compound relationships for IL15 gene (see all 72)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 70.1 58 11274230 (4), 17986095 (4), 18492658 (3), 11746532 (3) (see all 41)
    il-12 52.5 13 19698229 (5), 12850791 (1), 16471244 (1), 16024007 (1)
    gliadin 46.1 11 20153259 (3), 11040186 (1), 17100768 (1), 12853196 (1) (see all 8)
    alpha-galactosylceramide 45.9 14 10715513 (4), 11150537 (3), 17312126 (1), 12960313 (1) (see all 5)
    blys 43.4 1 16920570 (1)
    gm-csf 42.5 4 12494899 (1), 17082320 (1), 12893770 (1)
    ccl3 39 1 17170049 (1)
    il 10 38.8 6 9743948 (3), 10641032 (1), 19505916 (1), 20083555 (1)
    poly(i-c) 38.3 4 12960048 (1), 15196204 (1), 16299289 (1)
    gluten 33.1 9 17100768 (4), 18667914 (1), 15925843 (1), 16728270 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about IL15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL15 gene (3 alternative transcripts): 
    NM_000585.4  NM_172175.2  NM_172174.2  

    Unigene Cluster for IL15:

    Interleukin 15
    Hs.168132  [show with all ESTs]
    Unigene Representative Sequence: NR_037840
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000320650 ENST00000296545(uc010iol.3 uc003iis.3 uc003iit.3)
    ENST00000514653 ENST00000529613 ENST00000477265 ENST00000505351 ENST00000509249
    ENST00000394159
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate IL15 (see all 19):
    hsa-miR-640 hsa-miR-376b hsa-miR-4272 hsa-miR-15a hsa-miR-4263 hsa-miR-944 hsa-miR-3074-3p hsa-miR-424
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF031167.1 AK290619.1 AY720442.1 BC018149.2 BC100961.1 BC100962.1 BC100963.1 CR541980.1 
    CR542007.1 NR_037840.2 U14407.1 X94222.1 X94223.1 Z38000.1 

    6 DOTS entries:

    DT.75161076  DT.455390  DT.100747304  DT.100675458  DT.121276333  DT.100747305 

    24/68 AceView cDNA sequences (see all 68):

    CR617480 NM_172175 CR541980 CR542007 BE870325 AW418813 BM848565 CR617455 
    BX116580 AA973334 BX504391 AI656394 NM_172174 AA897685 X94223 AI719764 
    BI758686 AI148732 AI188915 BX119203 BI756810 BI832895 AI379606 AF031167 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for IL15 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
    SP1:                          -     -     -     -                       -     -                                       
    SP2:              -           -     -     -     -                       -     -                                       
    SP3:                                                                    -                                             
    SP4:                          -           -     -     -                 -     -                                       
    SP5:              -                       -     -                                                                     


    ECgene alternative splicing isoforms for IL15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL15 expression in normal human tissues (normalized intensities)      IL15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACAGTAGA
    IL15 Expression
    About this image


    IL15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             monocytes   
     
     Testis (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Adipose (Muscoskeletal System)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad

    Genevestigator expression for IL15

    SOURCE GeneReport for Unigene cluster: Hs.168132

    UniProtKB/Swiss-Prot: IL15_HUMAN, P40933
    Tissue specificity: Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver
    and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL15 (see all 15): 
              NFKB Signaling Targets in human mouse rat
              Antiviral Response in human mouse rat
              Leukemia in human mouse rat
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL15 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il151 , 5 interleukin 151, 5 80.45(n)1
    72.84(a)1
      8 (39.33 cM)5
    161681  NM_001254747.11  NP_001241676.11 
     823316245 
    chicken
    (Gallus gallus)
    Aves IL156
    interleukin 15
    35(a)
    1 ↔ 1
    4(29463073-29495702)
    lizard
    (Anolis carolinensis)
    Reptilia IL156
    interleukin 15
    26(a)
    1 ↔ 1
    5(119295130-119308201)


    ENSEMBL Gene Tree for IL15 (if available)
    TreeFam Gene Tree for IL15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1735 SNPs in IL15 are shown (see all 1735)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58625411,2
    C--138329529(+) GTTGA-/T/TT  
            
    TTTTT
    3 -- int1 trp32NA 4
    rs1408572651,2
    --142340712(+) TTTATA/GTATCA 3 -- us2k10--------
    rs1421664441,2
    C--142340811(+) GCCTT-/AAAGTT 3 -- us2k10--------
    rs1441401641,2
    C--142340940(+) AGTCC-/TGCAGA 3 -- us2k10--------
    rs1145664471,2
    F--142341104(+) CTGAGC/TGTGGA 3 -- us2k11Minor allele frequency- T:0.03WA 118
    rs799824021,2
    C,F--142341126(+) TTCACC/TGGCTG 3 -- us2k11Minor allele frequency- T:0.05WA 118
    rs781878241,2
    F--142341314(+) TTGTGG/ATGAGA 3 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1447002041,2
    C--142341349(+) TCCCAA/GTGCAT 3 -- us2k10--------
    rs1478305511,2
    --142341358(+) ATGCTC/TATTCT 3 -- us2k10--------
    rs1396314811,2
    --142341458(+) CGTCAA/TGAACA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL15 (142557749 - 142655140 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IL15:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830094CNV Loss17160897
    nsv880172CNV Loss21882294
    nsv880173CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600554    OMIM disorders: --

    20/161 diseases for IL15 (see all 161):    About MalaCards
    gamma chain deficiency    rasmussen encephalitis    microscopic colitis    t-cell large granular lymphocyte leukemia
    large granular lymphocyte leukemia    severe combined immunodeficiency    scrub typhus    cardiac sarcoidosis
    acute graft versus host disease    melioidosis    diabetic foot ulcers    typhus
    graft versus host disease    polymyositis    radiculopathy    lymphopenia
    celiac disease    sarcoidosis    mycosis fungoides    autoimmune thyroiditis

    1 disease from the University of Copenhagen DISEASES database for IL15:
    Rheumatoid arthritis

    IL15 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/89 Novoseek inferred disease relationships for IL15 gene (see all 89)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    severe combined immunodeficiency, x-linked 80.6 25 7632950 (3), 8026467 (1), 7803808 (1), 8605322 (1) (see all 17)
    necrosis 64.5 151 12878725 (2), 19967592 (2), 11817607 (2), 7523571 (1) (see all 99)
    rheumatoid arthritis 61.1 70 10679127 (5), 18557790 (2), 16362448 (2), 20007590 (2) (see all 52)
    tumors 54.4 242 7585540 (4), 11418694 (4), 14984938 (4), 19190330 (3) (see all 99)
    autoimmune diseases 54.1 26 11315928 (3), 12905728 (2), 16387851 (1), 19166383 (1) (see all 21)
    inflammation 53.7 71 15996196 (3), 15843549 (2), 19805228 (2), 11197599 (2) (see all 57)
    graft-versus-host disease 52.7 6 15976176 (2), 16860714 (1), 18641363 (1), 15280205 (1)
    celiac disease 47.3 21 12949719 (5), 17324400 (4), 11040186 (2), 19237603 (2) (see all 9)
    synovitis 43.4 14 17289161 (2), 12379638 (1), 16142748 (1), 12527218 (1) (see all 11)
    autoimmunity 42.5 5 17318811 (1), 18053164 (1), 18313361 (1), 18621751 (1) (see all 5)

    Genetic Association Database (GAD): IL15
    Human Genome Epidemiology (HuGE) Navigator: IL15 (49 documents)

    Export disorders for IL15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL15 gene, integrated from 9 sources (see all 1396):
    (articles sorted by number of sources associating them with IL15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. (PubMed id 8178155)1, 2, 3, 9 Grabstein K.H.... Giri J.G. (1994)
    2. Influences of genetic variants in interleukin-15 gene and serum interleukin-15 levels on coronary heart disease. (PubMed id 19796965)1, 4, 9 Gokkusu C....Umman B. (2010)
    3. IL15 gene variants are not associated with asthma and atopy. (PubMed id 19133918)1, 4, 9 Pinto L.A....Kabesch M. (2009)
    4. Molecular screening and association study of IL15 gene polymorphisms in rheumatoid arthritis. (PubMed id 17616399)1, 4, 9 Rueda B....Martin J. (2007)
    5. Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines. (PubMed id 8668345)1, 2, 9 Meazza R.... Ferrini S. (1996)
    6. Cytokine and cytokine receptor single-nucleotide poly morphisms predict risk for non-small cell lung cancer among women. (PubMed id 19505916)1, 4, 9 Van Dyke A.L....Schwartz A.G. (2009)
    7. Polymorphisms in interleukin-15 gene on chromosome 4q31.2 are associated with psoriasis vulgaris in Chinese population. (PubMed id 17554368)1, 4, 9 Zhang X.J....Liu J.J. (2007)
    8. The role of interleukin-15 polymorphisms in adult acu te lymphoblastic leukemia. (PubMed id 21049047)1, 4 Lin D....Liu H. (2010)
    9. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3600 HGNC: 5977 AceView: IL15 Ensembl:ENSG00000164136 euGenes: HUgn3600
    ECgene: IL15 Kegg: 3600 H-InvDB: IL15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL15 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL15 Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine source book: IL-15http://www.rndsystems.com/molecule_detail.aspx?m=1671
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_15

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL15 gene:
    Search GeneIP for patents involving IL15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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