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Aliases for IL15 Gene

Aliases for IL15 Gene

  • Interleukin 15 2 3 5
  • IL-15 3 4
  • Interleukin-15 3

External Ids for IL15 Gene

Previous GeneCards Identifiers for IL15 Gene

  • GC04P143420
  • GC04P142875
  • GC04P143023
  • GC04P143135
  • GC04P142915
  • GC04P142557
  • GC04P138287

Summaries for IL15 Gene

Entrez Gene Summary for IL15 Gene

  • The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]

GeneCards Summary for IL15 Gene

IL15 (Interleukin 15) is a Protein Coding gene. Diseases associated with IL15 include Rheumatoid Arthritis and Cutaneous T Cell Lymphoma. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include cytokine activity and cytokine receptor binding.

UniProtKB/Swiss-Prot for IL15 Gene

  • Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.

Gene Wiki entry for IL15 Gene

Additional gene information for IL15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL15 Gene

Genomics for IL15 Gene

GeneHancer (GH) Regulatory Elements for IL15 Gene

Promoters and enhancers for IL15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I141635 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.4 405 2.4 PKNOX1 SIN3A BATF YY1 ZNF335 GLIS2 ATF7 KLF7 ETV6 IKZF2 IL15 GC04P141671
GH04I141638 Enhancer 0.5 FANTOM5 562.2 +1.9 1869 0.3 PKNOX1 IKZF1 CHD1 IL15 ZNF330 GC04P141671
GH04I141642 Enhancer 1 FANTOM5 Ensembl ENCODE 20.8 +6.9 6862 1.8 ZSCAN21 SP1 PKNOX1 JUND PRDM6 FOSL2 FOS IL15 ZNF330 GC04P141671
GH04I141349 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 13.9 -286.0 -285993 1.9 FOXA2 MAX RAD21 YY1 FOSL2 TCF7L2 STAT1 RXRA CEBPB REST LINC02432 IL15 ZNF330 ENSG00000250189
GH04I141328 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -306.9 -306935 3.1 HDAC1 JUN MAX CEBPG RFX5 GATA3 POLR2A RCOR1 FOSL2 DEK LINC02432 IL15 ZNF330 ENSG00000248747
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IL15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL15 gene promoter:

Genomic Locations for IL15 Gene

Genomic Locations for IL15 Gene
chr4:141,636,596-141,733,987
(GRCh38/hg38)
Size:
97,392 bases
Orientation:
Plus strand
chr4:142,557,749-142,655,140
(GRCh37/hg19)

Genomic View for IL15 Gene

Genes around IL15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL15 Gene

Proteins for IL15 Gene

  • Protein details for IL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40933-IL15_HUMAN
    Recommended name:
    Interleukin-15
    Protein Accession:
    P40933
    Secondary Accessions:
    • D3DNZ2
    • O00440
    • O43512
    • Q495Z8
    • Q6FGX7
    • Q93058
    • Q9UBA3

    Protein attributes for IL15 Gene

    Size:
    162 amino acids
    Molecular mass:
    18086 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA71044.1; Type=Miscellaneous discrepancy; Note=Man-made cDNA with a signal peptide sequence to increase protein secretion (substitution with a signal peptide derived from the mouse IgV kappa chain).; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL15 Gene

    Alternative splice isoforms for IL15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL15 Gene

Post-translational modifications for IL15 Gene

Other Protein References for IL15 Gene

No data available for DME Specific Peptides for IL15 Gene

Domains & Families for IL15 Gene

Gene Families for IL15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for IL15 Gene

Suggested Antigen Peptide Sequences for IL15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P40933

UniProtKB/Swiss-Prot:

IL15_HUMAN :
  • Belongs to the IL-15/IL-21 family.
Family:
  • Belongs to the IL-15/IL-21 family.
genes like me logo Genes that share domains with IL15: view

Function for IL15 Gene

Molecular function for IL15 Gene

GENATLAS Biochemistry:
interleukin 15,structurally and functionally related to IL2,involved in the differentiation of natural killer cells
UniProtKB/Swiss-Prot Function:
Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.

LifeMap Function Summary for IL15 Gene

IL15 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for IL15 Gene

Gene Ontology (GO) - Molecular Function for IL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005126 cytokine receptor binding IEA --
GO:0005515 protein binding IPI 16284400
genes like me logo Genes that share ontologies with IL15: view
genes like me logo Genes that share phenotypes with IL15: view

Animal Models for IL15 Gene

MGI Knock Outs for IL15:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL15 Gene

Localization for IL15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL15 Gene

Isoform IL15-S48AA: Secreted.
Isoform IL15-S21AA: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL15 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
endosome 5
golgi apparatus 4
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,TAS --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 10851076
genes like me logo Genes that share ontologies with IL15: view

Pathways & Interactions for IL15 Gene

genes like me logo Genes that share pathways with IL15: view

SIGNOR curated interactions for IL15 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001779 natural killer cell differentiation IEA --
GO:0001866 NK T cell proliferation IEA --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA,TAS --
GO:0007165 signal transduction TAS 8178155
genes like me logo Genes that share ontologies with IL15: view

Drugs & Compounds for IL15 Gene

(38) Drugs for IL15 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AMG0714 Pharma 0

(35) Additional Compounds for IL15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL15: view

Transcripts for IL15 Gene

Unigene Clusters for IL15 Gene

Interleukin 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
SP1: - - - - - -
SP2: - - - - - - -
SP3: -
SP4: - - - - - -
SP5: - - -
SP6:

Relevant External Links for IL15 Gene

GeneLoc Exon Structure for
IL15
ECgene alternative splicing isoforms for
IL15

Expression for IL15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of IL15 Gene:

IL15

SOURCE GeneReport for Unigene cluster for IL15 Gene:

Hs.168132

mRNA Expression by UniProt/SwissProt for IL15 Gene:

P40933-IL15_HUMAN
Tissue specificity: Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus.

Evidence on tissue expression from TISSUES for IL15 Gene

  • Bone marrow(4.5)
  • Intestine(4.5)
  • Skin(4.4)
  • Nervous system(4.4)
  • Heart(4.3)
  • Blood(3.1)
  • Lymph node(3)
  • Spleen(3)
  • Muscle(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with IL15: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL15 Gene

Orthologs for IL15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL15 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia IL15 33 34
  • 87.86 (n)
dog
(Canis familiaris)
Mammalia IL15 33 34
  • 84.16 (n)
mouse
(Mus musculus)
Mammalia Il15 33 16 34
  • 80.45 (n)
rat
(Rattus norvegicus)
Mammalia Il15 33
  • 79.84 (n)
oppossum
(Monodelphis domestica)
Mammalia IL15 34
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL15 34
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL15 34
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL15 34
  • 26 (a)
OneToOne
Species where no ortholog for IL15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL15 Gene

ENSEMBL:
Gene Tree for IL15 (if available)
TreeFam:
Gene Tree for IL15 (if available)

Paralogs for IL15 Gene

No data available for Paralogs for IL15 Gene

Variants for IL15 Gene

Sequence variations from dbSNP and Humsavar for IL15 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000087987 -- 141,679,672(+) T/C intron_variant
rs1000098890 -- 141,697,142(+) G/A intron_variant
rs1000114336 -- 141,649,693(+) A/G intron_variant
rs1000117832 -- 141,662,195(+) T/C intron_variant
rs1000125541 -- 141,727,496(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IL15 Gene

Variant ID Type Subtype PubMed ID
esv3564735 CNV deletion 23714750
nsv1018949 CNV gain 25217958
nsv830094 CNV loss 17160897

Variation tolerance for IL15 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL15 Gene

Disorders for IL15 Gene

MalaCards: The human disease database

(21) MalaCards diseases for IL15 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rheumatoid arthritis
  • ra
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
severe combined immunodeficiency
  • combined t and b cell inborn immunodeficiency
jak3-deficient severe combined immunodeficiency
  • autosomal recessive t cell-negative, b cell-positive, nk cell-negative severe combined immunodeficiency
refractory celiac disease
  • refractory cd
- elite association - COSMIC cancer census association via MalaCards
Search IL15 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL15 Gene

Publications for IL15 Gene

  1. Influences of genetic variants in interleukin-15 gene and serum interleukin-15 levels on coronary heart disease. (PMID: 19796965) Gokkusu C … Umman B (Cytokine 2010) 3 22 44 58
  2. Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women. (PMID: 19505916) Van Dyke AL … Schwartz AG (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 22 44 58
  3. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. (PMID: 8178155) Grabstein KH … Ahdieh M (Science (New York, N.Y.) 1994) 2 3 4 58
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
  5. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PMID: 20140262) Ryckman KK … Jacobsson B (PloS one 2010) 3 44 58

Products for IL15 Gene

Sources for IL15 Gene

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