Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL13RA2 Gene

protein-coding   GIFtS: 58
GCID: GC0XM114238

Interleukin 13 Receptor, Alpha 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 13 Receptor, Alpha 21 2     CT192
Cancer/Testis Antigen 191 2     IL-13R2
Interleukin-13-Binding Protein2 3     IL13BP2
IL-13R-alpha-22 3     Interleukin 13 Binding Protein2
IL-13RA22 3     Interleukin 13 Receptor Alpha 2 Chain2
IL-13 Receptor Subunit Alpha-22 3     Interleukin-13 Receptor Subunit Alpha-22
IL-13R Subunit Alpha-22 3     IL13R3
CD213A22     CD213a2 Antigen3

External Ids:    HGNC: 59751   Entrez Gene: 35982   Ensembl: ENSG000001234967   OMIM: 3001305   UniProtKB: Q146273   

Export aliases for IL13RA2 gene to outside databases

Previous GC identifers: GC0XM109214 GC0XM111363 GC0XM112274 GC0XM113005 GC0XM113006 GC0XM114061 GC0XM103824


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL13RA2 Gene:
The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex.
This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a
signal mediator. It is reported to play a role in the internalization of IL13. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL13RA2 Gene: 
IL13RA2 (interleukin 13 receptor, alpha 2) is a protein-coding gene. Diseases associated with IL13RA2 include malignant glioma, and nonalcoholic steatohepatitis, and among its related super-pathways are Akt Signaling and TGF-Beta Pathway. GO annotations related to this gene include cytokine receptor activity and signal transducer activity. An important paralog of this gene is IL5RA.

UniProtKB/Swiss-Prot: I13R2_HUMAN, Q14627
Function: Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4)

Gene Wiki entry for IL13RA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_028405.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL13RA2 gene promoter:
         STAT1   ATF-2   CUTL1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   GATA-1   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL13RA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL13RA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL13RA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1-q28   Ensembl cytogenetic band:  Xq23   HGNC cytogenetic band: Xq13.1-q28

IL13RA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL13RA2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM114238:  view genomic region     (about GC identifiers)

Start:
114,238,538 bp from pter      End:
114,254,540 bp from pter
Size:
16,003 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: I13R2_HUMAN, Q14627 (See protein sequence)
Recommended Name: Interleukin-13 receptor subunit alpha-2 precursor  
Size: 380 amino acids; 44176 Da
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for IL13RA2:
3LB6 (3D)    
Secondary accessions: A8K7E2 O00667

Explore the universe of human proteins at neXtProt for IL13RA2: NX_Q14627

Explore proteomics data for IL13RA2 at MOPED 

IL13RA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IL13RA2 Protein Expression

REFSEQ proteins: NP_000631.1  
ENSEMBL proteins: 
 ENSP00000361004   ENSP00000243213  

Human Recombinant Protein Products for IL13RA2: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for IL13RA2 (IL-13 R alpha 2)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for IL13RA2
OriGene Custom MassSpec 
OriGene Custom Protein Services for IL13RA2
GenScript Custom Purified and Recombinant Proteins Services for IL13RA2
Novus Biologicals IL13RA2 Proteins
Novus Biologicals IL13RA2 Lysates
Sino Biological Recombinant Protein for IL13RA2
Sino Biological Cell Lysate for IL13RA2 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space TAS9083087
GO:0016021integral to membrane IEA--

IL13RA2 for ontologies           About GeneDecksing



IL13RA2 Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of IL13RA2
R&D Systems Antibodies for IL13RA2 (IL-13 R alpha 2)
Browse OriGene Antibodies
OriGene Custom Antibody Services for IL13RA2
GenScript Custom Superior Antibodies Services for IL13RA2
Novus Biologicals IL13RA2 Antibodies
Abcam antibodies for IL13RA2
Browse Antibodies at Cloud-Clone Corp. 
Search ThermoFisher Antibodies for IL13RA2
LSBio Antibodies in human, mouse, rat for IL13RA2 

Assay Products for IL13RA2: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for IL13RA2
R&D Systems ELISAs for IL13RA2 (IL-13 R alpha 2)
GenScript Custom Assay Services for IL13RA2
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
CD: CD molecules
IL: Interleukins and interleukin receptors

IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 13 receptor, α2 
IL-2 receptor family

4 InterPro protein domains:
 IPR015321 IL6_recept-bd
 IPR003961 Fibronectin_type3
 IPR013783 Ig-like_fold
 IPR003532 Short_hematopoietin_rcpt_2_CS

Graphical View of Domain Structure for InterPro Entry Q14627

ProtoNet protein and cluster: Q14627

UniProtKB/Swiss-Prot: I13R2_HUMAN, Q14627
Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
transport and cell-surface receptor binding
Domain: The box 1 motif is required for JAK interaction and/or activation
Similarity: Belongs to the type I cytokine receptor family. Type 5 subfamily
Similarity: Contains 3 fibronectin type-III domains


IL13RA2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: I13R2_HUMAN, Q14627
Function: Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4)

     Genatlas biochemistry entry for IL13RA2:
interleukin 13 receptor,alpha

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004871signal transducer activity TAS9725226
GO:0004896cytokine receptor activity TAS9725226
GO:0005515protein binding ----
     
IL13RA2 for ontologies           About GeneDecksing


Phenotypes:
     3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il13ra2):
 hematopoietic system  homeostasis/metabolism  immune system 

IL13RA2 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Il13ra2tm1Gru for IL13RA2

   inGenious Targeting Laboratory - Custom generated mouse model solutions for IL13RA2 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL13RA2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL13RA2 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL13RA2 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL13RA2
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL13RA2
SwitchGear 3'UTR luciferase reporter plasmidIL13RA2 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL13RA2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL13RA2

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IL13RA2
Sirion Biotech Customized adenovirus for overexpression of IL13RA2

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for IL13RA2 (see all 5)
OriGene ORF clones in mouse, rat for IL13RA2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL13RA2 (NM_000640)
Sino Biological Human cDNA Clone for IL13RA2
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL13RA2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL13RA2
Sirion Biotech Customized lentivirus for stable overexpression of IL13RA2 
                     Customized lentivirus expression plasmids for stable overexpression of IL13RA2 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IL13RA2
Search LifeMap BioReagents cell lines for IL13RA2
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL13RA2


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IL13RA2 About   (see all 7)                                                                                              See pathways by source

SuperPathContained pathways About
1Akt Signaling
Akt Signaling0.60
Tec Kinases Signaling0.55
p38 Signaling0.60
2TGF-Beta Pathway
MAPK Family Pathway0.60
3PAK Pathway
Antioxidant Action of Vitamin-C0.56
4Rho Family GTPases
Molecular Mechanisms of Cancer0.51
5PEDF Induced Signaling
STAT3 Pathway0.47

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL13RA2 (see all 7)
    STAT3 Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
p38 Signaling
Akt Signaling

1 BioSystems Pathway for IL13RA2
    IL4-mediated signaling events



1         Kegg Pathway  (Kegg details for IL13RA2):
    Jak-STAT signaling pathway


IL13RA2 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL13RA2

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/17 Interacting proteins for IL13RA2 (Q146273 ENSP000002432134) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
InteractantInteraction Details
GeneCardExternal ID(s)
IL4P051123, ENSP000002314494I2D: score=1 STRING: ENSP00000231449
IL13P352253, ENSP000003049154I2D: score=2 STRING: ENSP00000304915
STAT6ENSP000003001344STRING: ENSP00000300134
CBLENSP000002640334STRING: ENSP00000264033
CBLBENSP000002641224STRING: ENSP00000264122
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007165signal transduction TAS9725226
GO:0019221cytokine-mediated signaling pathway TAS9725226

IL13RA2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL13RA2 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL13RA2 (I13R2)

2 Novoseek inferred chemical compound relationships for IL13RA2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
lysine 0 2 15448012 (1)
glutamate 0 1 15448012 (1)

Search CenterWatch for drugs/clinical trials and news about IL13RA2 / I13R2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL13RA2 gene: 
NM_000640.2  

Unigene Cluster for IL13RA2:

Interleukin 13 receptor, alpha 2
Hs.336046  [show with all ESTs]
Unigene Representative Sequence: AK308523
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000371936(uc004epx.3) ENST00000468224 ENST00000243213(uc010nqd.1 uc022cdb.1)

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL13RA2
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL13RA2
SwitchGear 3'UTR luciferase reporter plasmidIL13RA2 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL13RA2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL13RA2
Clone
Products:
     
OriGene clones in human, mouse for IL13RA2 (see all 5)
OriGene ORF clones in mouse, rat for IL13RA2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL13RA2 (NM_000640)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL13RA2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL13RA2
Sirion Biotech Customized lentivirus for stable overexpression of IL13RA2 
                     Customized lentivirus expression plasmids for stable overexpression of IL13RA2 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for IL13RA2
OriGene qSTAR qPCR primer pairs in human, mouse for IL13RA2
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL13RA2
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL13RA2
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL13RA2

Additional mRNA sequence: 

AK291957.1 AK308523.1 AK309444.1 BC020739.1 BC033705.2 GQ494004.1 U70981.1 X95302.1 
Y08768.1 

3 DOTS entries:

DT.210328  DT.100834188  DT.121296359 

24/50 AceView cDNA sequences (see all 50):

BP369407 X95302 CR623092 CR594473 BQ225471 AW954333 U70981 BX282434 
BQ432114 CD672811 BC033705 AA621766 BG723203 CB269805 BC020739 BG778615 
BI828427 BU561217 NM_000640 BM541457 BF591502 BU852265 AA298563 AA909507 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL13RA2 expression in normal human tissues (normalized intensities)      IL13RA2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCAAATGTT
IL13RA2 Expression
About this image


IL13RA2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/11 selected tissues (see all 11) fully expand
 
 Eye (Sensory Organs)    fully expand to see all 4 entries
         Human corneal endothelial cells
         Human Iris Pigment Epithelial Cells (HIPEpiC)   
         retinal progenitor cell e12.5   
 
 Lung (Respiratory System)    fully expand to see all 2 entries
         Basal Cells Respiratory Bronchioles
         Human Pulmonary Fibroblasts (HPF)   
 
 Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
         Normal Human Articular chondrocytes (NHAC)   
 
 Fibroblast (Endocrine System)    fully expand to see all 2 entries
         Human Prostate Fibroblasts (HPrF)   
 
 Adipose (Muscoskeletal System)    fully expand to see all 2 entries
         Human Preadipocyte-visceral (HPA-v)   

See IL13RA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL13RA2

SOURCE GeneReport for Unigene cluster: Hs.336046
    SABiosciences Expression via Pathway-Focused PCR Arrays including IL13RA2: 
          Fibrosis in human mouse rat
          Interferons & Receptors in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Allergy & Asthma in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for IL13RA2
OriGene qSTAR qPCR primer pairs in human, mouse for IL13RA2
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL13RA2
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL13RA2
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL13RA2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL13RA2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL13RA2 gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il13ra21 , 5 interleukin 13 receptor, alpha 21, 5 73.24(n)1
60(a)1
  X (68.46 cM)5
161651  NM_008356.31  NP_032382.11 
 1473834765 
chicken
(Gallus gallus)
Aves IL13RA21 interleukin 13 receptor, alpha 2 53.05(n)
41.46(a)
  422219  NM_001048078.1  NP_001041543.1 
zebrafish
(Danio rerio)
Actinopterygii il13ra21 interleukin 13 receptor, alpha 2 49.78(n)
38.39(a)
  368326  NM_001113731.1  NP_001107203.1 


ENSEMBL Gene Tree for IL13RA2 (if available)
TreeFam Gene Tree for IL13RA2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for IL13RA2 gene
IL5RA2  IL13RA12  

IL13RA2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/258 SNPs in IL13RA2 are shown (see all 258)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs5386871,2
C,F,A--114219661(-) tacacA/Ggaagg 1 -- ds50016Minor allele frequency- G:0.36NA NS WA CSA 99
rs1859446271,2
--114219683(+) AGGTAC/TGCGCC 1 -- ds50010--------
rs170958631,2
C,F--114219686(-) GGTGGC/TGCGTA 1 -- ds50012Minor allele frequency- T:0.01NS 92
rs1907488261,2
--114219694(+) ACCATA/GCCTGG 1 -- ds50010--------
rs170958641,2
C,F--114219702(-) AAAATT/CAGCCA 1 -- ds50013Minor allele frequency- C:0.07NS CSA 93
rs170958671,2
C,F--114219725(-) CCCCAT/GTTCTA 1 -- ds50012Minor allele frequency- G:0.01NS 92
rs1839195861,2
--114220157(+) AAGACA/GTATTC 1 -- ds50010--------
rs170949941,2
C,F--114220396(-) GCTTCA/CCTTTG 1 -- int15Minor allele frequency- C:0.10NS NA CSA 97
rs1876894491,2
--114220580(+) CCATCG/TCTATA 1 -- int10--------
rs1925083221,2
--114220672(+) CTGTAA/GTCCCA 1 -- int10--------

HapMap Linkage Disequilibrium report for IL13RA2 (114238538 - 114254540 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for IL13RA2:    About this table     
Variant IDTypeSubtypePubMed ID
nsv513764CNV Insertion21212237
nsv511667CNV Gain21212237
nsv516624CNV Gain19592680
esv33994CNV Gain+Loss17666407


Locus Specific Mutation Databases (LSDB): IL13RA2
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing IL13RA2
DNA2.0 Custom Variant and Variant Library Synthesis for IL13RA2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 300130    OMIM disorders: --

20/40 diseases for IL13RA2 (see all 40):    About MalaCards
malignant glioma    nonalcoholic steatohepatitis    burkitt's lymphoma    cblc
idiopathic interstitial pneumonia    kaposi's sarcoma    pancreatic ductal adenocarcinoma    glioblastoma
diphtheria    pneumonia    allergic rhinitis    medulloblastoma
rhinitis    mastocytosis    measles    atopy
ulcerative colitis    bronchiolitis    purpura    astrocytoma

1 disease from the University of Copenhagen DISEASES database for IL13RA2:
Malignant glioma

IL13RA2 for disorders           About GeneDecksing

10/26 Novoseek inferred disease relationships for IL13RA2 gene (see all 26)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
malignant glioma 69.7 6 16740728 (1), 18430795 (1), 11939409 (1), 17328684 (1) (see all 6)
glioblastoma multiforme 69.1 5 17804706 (2), 10946814 (1), 18665158 (1), 12231526 (1)
glioma 67.6 8 9590132 (1), 10946814 (1), 9815919 (1), 17805488 (1) (see all 6)
asthma allergic 63.5 2 15331327 (1), 10686479 (1)
glioblastoma 54.1 6 15803373 (2), 18677476 (1), 12816724 (1), 15047912 (1) (see all 5)
brain tumors 51.4 3 17328684 (1), 15047912 (1), 11083073 (1)
astrocytoma 46.2 3 18172271 (2), 18590440 (1)
carcinoma renal cell 39.9 5 8663118 (1), 9816125 (1), 10388747 (1), 15297430 (1)
diphtheria 39.2 1 19916021 (1)
tumors 36.1 19 16902988 (2), 14673019 (1), 18665158 (1), 20068108 (1) (see all 13)

Genetic Association Database (GAD): IL13RA2
Human Genome Epidemiology (HuGE) Navigator: IL13RA2 (9 documents)

Export disorders for IL13RA2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IL13RA2 gene, integrated from 9 sources (see all 196):
(articles sorted by number of sources associating them with IL13RA2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain. (PubMed id 8663118)1, 2, 3, 9 Caput D....Ferrara P. (1996)
  2. IL13RA2 gene polymorphisms are associated with systemic sclerosis. (PubMed id 16981293)1, 4, 9 Granel B....Dessein A. (2006)
  3. Chromosome mapping and expression of the human interleukin-13 receptor. (PubMed id 9177784)1, 2, 9 Guo J.... Minvielle S. (1997)
  4. Identification of fetal and maternal single nucleotid e polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (2010)
  5. A genetic association study of maternal and fetal can didate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (2010)
  6. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
  7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
  8. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
  9. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
  10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3598 HGNC: 5975 AceView: IL13RA2 Ensembl:ENSG00000123496 euGenes: HUgn3598
ECgene: IL13RA2 Kegg: 3598 H-InvDB: IL13RA2

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IL13RA2 Pharmacogenomics, SNPs, Pathways
SeattleSNPshttp://pga.gs.washington.edu/data/il13ra2/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IL13RA2 gene:
Search GeneIP for patents involving IL13RA2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 Browse Small Molecules at EMD Millipore
 Browse for Gene Knock-down Tools from EMD Millipore
 Browse Kits and Assays available from EMD Millipore
 EMD Millipore Mono- and Polyclonal Antibodies for the study of IL13RA2
 Browse Purified and Recombinant Proteins at EMD Millipore
 Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Antibodies for IL13RA2 (IL-13 R alpha 2)   Browse Cell Culture Products  
 ELISAs for IL13RA2 (IL-13 R alpha 2)   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for IL13RA2 (IL-13 R alpha 2)  
 Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for IL13RA2  
 OriGene qPCR primer pairs and template standards for IL13RA2   OriGene Protein Over-expression Lysate for IL13RA2  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for IL13RA2  
 OriGene qSTAR qPCR primer pairs in human, mouse for IL13RA2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for IL13RA2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for IL13RA2   OriGene Custom Protein Services for IL13RA2  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL13RA2
 QIAGEN SeqTarget long-range PCR primers for resequencing IL13RA2
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL13RA2
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL13RA2
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL13RA2
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL13RA2
 GenScript Custom Purified and Recombinant Proteins Services for IL13RA2 GenScript cDNA clones with any tag delivered in your preferred vector for IL13RA2
 GenScript Custom Assay Services for IL13RA2 GenScript Custom Superior Antibodies Services for IL13RA2
 GenScript Custom overexpressing Cell Line Services for IL13RA2 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in IL13RA2 promoter
 Search Chromatin IP Primers for IL13RA2
 RT2 qPCR Primer Assay in human, mouse, rat IL13RA2
 GNC Network for IL13RA2
 SABiosciences PCR Arrays including human, mouse, rat IL13RA2
 Search Tocris compounds for IL13RA2 (I13R2)
 Proteins and Antibodies for IL13RA2
 Cell Lysates for IL13RA2
 cDNA Clones for IL13RA2
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 IL13RA2 antibodies
 IL13RA2 proteins
 IL13RA2 lysates
 Antibodies for IL13RA2
 See all of Abcam's Antibodies, Kits and Proteins for IL13RA2
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.
 Search LifeMap BioReagents cell lines for IL13RA2
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL13RA2
 SwitchGear 3'UTR luciferase reporter plasmids for IL13RA2
 SwitchGear Promoter luciferase reporter plasmids for IL13RA2
 Search ThermoFisher Antibodies for IL13RA2
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL13RA2
 inGenious Targeting Laboratory - Custom generated mouse model solutions for IL13RA2
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL13RA2
Customized:
 lentivirus for stable overexpression of IL13RA2
 lentivirus expression plasmids for stable overexpression of IL13RA2
 adenovirus for overexpression of IL13RA2
 LSBio Antibodies in human, mouse, rat for IL13RA2
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      IL13RA2 gene at Home site.
hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4