Aliases for IL13RA2 Gene
External Ids for IL13RA2 Gene
Previous GeneCards Identifiers for IL13RA2 Gene
The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL13RA2 Gene
IL13RA2 (Interleukin 13 Receptor Subunit Alpha 2) is a Protein Coding gene. Diseases associated with IL13RA2 include Malignant Glioma and Glioblastoma Multiforme. Among its related pathways are Innate Immune System and Interleukin-4 and 13 signaling. GO annotations related to this gene include signal transducer activity and cytokine receptor activity. An important paralog of this gene is IL5RA.
UniProtKB/Swiss-Prot for IL13RA2 Gene
Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).