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Aliases for IL13RA2 Gene

Aliases for IL13RA2 Gene

  • Interleukin 13 Receptor Subunit Alpha 2 2 3 5
  • Interleukin 13 Receptor, Alpha 2 2 3
  • IL-13 Receptor Subunit Alpha-2 3 4
  • Cancer/Testis Antigen 19 2 3
  • IL-13R Subunit Alpha-2 3 4
  • IL-13R-Alpha-2 3 4
  • IL-13RA2 3 4
  • Interleukin-13 Receptor Subunit Alpha-2 3
  • Interleukin 13 Receptor Alpha 2 Chain 3
  • Interleukin 13 Binding Protein 3
  • Interleukin-13-Binding Protein 4
  • CD213a2 Antigen 4
  • CD213A2 3
  • IL-13R 3
  • IL13BP 3
  • IL13R 4
  • CT19 3

External Ids for IL13RA2 Gene

Previous GeneCards Identifiers for IL13RA2 Gene

  • GC0XM109214
  • GC0XM111363
  • GC0XM112274
  • GC0XM113005
  • GC0XM113006
  • GC0XM114061
  • GC0XM114238
  • GC0XM103824

Summaries for IL13RA2 Gene

Entrez Gene Summary for IL13RA2 Gene

  • The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL13RA2 Gene

IL13RA2 (Interleukin 13 Receptor Subunit Alpha 2) is a Protein Coding gene. Diseases associated with IL13RA2 include Malignant Glioma and Glioblastoma Multiforme. Among its related pathways are Innate Immune System and Interleukin-4 and 13 signaling. GO annotations related to this gene include signal transducer activity and cytokine receptor activity. An important paralog of this gene is IL5RA.

UniProtKB/Swiss-Prot for IL13RA2 Gene

  • Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).

Gene Wiki entry for IL13RA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL13RA2 Gene

Genomics for IL13RA2 Gene

Regulatory Elements for IL13RA2 Gene

Enhancers for IL13RA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG115029 0.8 Ensembl ENCODE 9.6 -10.7 -10697 2.3 CTBP1 NFIC GATA2 SMAD5 NFIB TCF7L2 IL13RA2 RNU6-648P
GH0XG115021 1 Ensembl ENCODE 6.7 -3.2 -3236 2.4 HDAC1 TAL1 JUN FOSL1 CCNT2 TCF12 ZNF316 GATA2 NCOR1 NFE2 IL13RA2 RNU6-648P
GH0XG115058 0.4 ENCODE 5.8 -38.6 -38589 0.8 JUND RNU6-648P IL13RA2 GC0XP115061 GC0XM115055
GH0XG115018 0.4 ENCODE 5.5 +0.9 937 1.3 CTCF IL13RA2 ENSG00000270413
GH0XG114976 0.2 ENCODE 0.3 +43.4 43425 0.2 IL13RA2 ENSG00000270413
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL13RA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL13RA2 Gene

Chromosome:
X
Start:
115,003,975 bp from pter
End:
115,019,977 bp from pter
Size:
16,003 bases
Orientation:
Minus strand

Genomic View for IL13RA2 Gene

Genes around IL13RA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL13RA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL13RA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL13RA2 Gene

Proteins for IL13RA2 Gene

  • Protein details for IL13RA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14627-I13R2_HUMAN
    Recommended name:
    Interleukin-13 receptor subunit alpha-2
    Protein Accession:
    Q14627
    Secondary Accessions:
    • A8K7E2
    • O00667

    Protein attributes for IL13RA2 Gene

    Size:
    380 amino acids
    Molecular mass:
    44176 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL13RA2 Gene

neXtProt entry for IL13RA2 Gene

Post-translational modifications for IL13RA2 Gene

  • Glycosylation at isoforms=115, isoforms=215, posLast=290290, and isoforms=299

Other Protein References for IL13RA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IL13RA2 (IL-13 R alpha 2)
  • Cloud-Clone Corp. Antibodies for IL13RA2

Protein Products

  • Cloud-Clone Corp. Proteins for IL13RA2

Assay Products

  • Cloud-Clone Corp Assay Kits for IL13RA2

No data available for DME Specific Peptides for IL13RA2 Gene

Domains & Families for IL13RA2 Gene

Protein Domains for IL13RA2 Gene

Suggested Antigen Peptide Sequences for IL13RA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q14627

UniProtKB/Swiss-Prot:

I13R2_HUMAN :
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • The box 1 motif is required for JAK interaction and/or activation.
Family:
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
genes like me logo Genes that share domains with IL13RA2: view

Function for IL13RA2 Gene

Molecular function for IL13RA2 Gene

GENATLAS Biochemistry:
interleukin 13 receptor,alpha
UniProtKB/Swiss-Prot Function:
Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).

Gene Ontology (GO) - Molecular Function for IL13RA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 9725226
GO:0004896 cytokine receptor activity TAS 9725226
genes like me logo Genes that share ontologies with IL13RA2: view
genes like me logo Genes that share phenotypes with IL13RA2: view

Animal Models for IL13RA2 Gene

MGI Knock Outs for IL13RA2:

Animal Model Products

miRNA for IL13RA2 Gene

miRTarBase miRNAs that target IL13RA2

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for IL13RA2 (IL-13 R alpha 2)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL13RA2 Gene

Localization for IL13RA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL13RA2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL13RA2 gene
Compartment Confidence
extracellular 4
plasma membrane 3
nucleus 2
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for IL13RA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 9083087
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL13RA2: view

Pathways & Interactions for IL13RA2 Gene

genes like me logo Genes that share pathways with IL13RA2: view

Pathways by source for IL13RA2 Gene

Gene Ontology (GO) - Biological Process for IL13RA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002638 negative regulation of immunoglobulin production IEA --
GO:0007165 signal transduction IEA --
GO:0016064 immunoglobulin mediated immune response IEA --
GO:0019221 cytokine-mediated signaling pathway IEA --
GO:0043305 negative regulation of mast cell degranulation IEA --
genes like me logo Genes that share ontologies with IL13RA2: view

No data available for SIGNOR curated interactions for IL13RA2 Gene

Drugs & Compounds for IL13RA2 Gene

(4) Drugs for IL13RA2 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AER001 Investigational Pharma Target 0
Cintredekin Besudotox Investigational Pharma 0
AER001,AEROVANT Pharma 0

(1) Additional Compounds for IL13RA2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL13RA2: view

Transcripts for IL13RA2 Gene

mRNA/cDNA for IL13RA2 Gene

Unigene Clusters for IL13RA2 Gene

Interleukin 13 receptor, alpha 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for IL13RA2 (IL-13 R alpha 2)

Alternative Splicing Database (ASD) splice patterns (SP) for IL13RA2 Gene

No ASD Table

Relevant External Links for IL13RA2 Gene

GeneLoc Exon Structure for
IL13RA2
ECgene alternative splicing isoforms for
IL13RA2

Expression for IL13RA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL13RA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL13RA2 Gene

This gene is overexpressed in Artery - Aorta (x9.3), Testis (x8.9), and Brain - Hypothalamus (x5.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IL13RA2 Gene



NURSA nuclear receptor signaling pathways regulating expression of IL13RA2 Gene:

IL13RA2

SOURCE GeneReport for Unigene cluster for IL13RA2 Gene:

Hs.336046

Evidence on tissue expression from TISSUES for IL13RA2 Gene

  • Nervous system(4.3)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with IL13RA2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL13RA2 Gene

Orthologs for IL13RA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL13RA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL13RA2 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia IL13RA2 34 35
  • 82.93 (n)
cow
(Bos Taurus)
Mammalia LOC616008 34
  • 82.21 (n)
IL13RA2 35
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il13ra2 34 16 35
  • 73.24 (n)
rat
(Rattus norvegicus)
Mammalia Il13ra2 34
  • 72.3 (n)
oppossum
(Monodelphis domestica)
Mammalia IL13RA2 35
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL13RA2 35
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL13RA2 34 35
  • 52.19 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia il13ra2 34
  • 51.86 (n)
zebrafish
(Danio rerio)
Actinopterygii il13ra2 34 35
  • 50 (n)
Species where no ortholog for IL13RA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL13RA2 Gene

ENSEMBL:
Gene Tree for IL13RA2 (if available)
TreeFam:
Gene Tree for IL13RA2 (if available)

Paralogs for IL13RA2 Gene

Paralogs for IL13RA2 Gene

genes like me logo Genes that share paralogs with IL13RA2: view

Variants for IL13RA2 Gene

Sequence variations from dbSNP and Humsavar for IL13RA2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000698631 -- 115,007,741(+) TATTC(C/T)TAGTC intron-variant
rs1001165087 -- 115,007,092(+) ATATC(C/T)GTAAT intron-variant
rs1001616535 -- 115,017,783(+) TATTT(C/T)GGCCG upstream-variant-2KB
rs1001871177 -- 115,008,430(+) GCTAC(A/C)TACAC intron-variant
rs1002531608 -- 115,008,883(+) TTGTA(A/G)GTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL13RA2 Gene

Variant ID Type Subtype PubMed ID
esv33994 CNV gain+loss 17666407
esv3577049 CNV gain 25503493
nsv511667 CNV gain 21212237
nsv513764 CNV insertion 21212237
nsv516624 CNV gain 19592680

Variation tolerance for IL13RA2 Gene

Residual Variation Intolerance Score: 23.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL13RA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL13RA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL13RA2 Gene

Disorders for IL13RA2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for IL13RA2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
malignant glioma
glioblastoma multiforme
  • adult glioblastoma multiforme
astrocytoma
  • astrocytic tumor
medulloblastoma
  • medulloblastoma, desmoplastic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IL13RA2

Genetic Association Database (GAD)
IL13RA2
Human Genome Epidemiology (HuGE) Navigator
IL13RA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL13RA2
genes like me logo Genes that share disorders with IL13RA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL13RA2 Gene

Publications for IL13RA2 Gene

  1. Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain. (PMID: 8663118) Caput D. … Ferrara P. (J. Biol. Chem. 1996) 2 3 4 22 64
  2. IL13RA2 gene polymorphisms are associated with systemic sclerosis. (PMID: 16981293) Granel B. … Dessein A. (J. Rheumatol. 2006) 3 22 46 64
  3. Chromosome mapping and expression of the human interleukin-13 receptor. (PMID: 9177784) Guo J. … Minvielle S. (Genomics 1997) 3 4 22 64
  4. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PMID: 20452482) Romero R. … Menon R. (Am. J. Obstet. Gynecol. 2010) 3 46 64
  5. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A. … Janssen R. (Pediatr. Pulmonol. 2010) 3 46 64

Products for IL13RA2 Gene

Sources for IL13RA2 Gene

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