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Aliases for IL13RA2 Gene

Aliases for IL13RA2 Gene

  • Interleukin 13 Receptor Subunit Alpha 2 2 3 5
  • Interleukin 13 Receptor, Alpha 2 2 3
  • Interleukin-13-Binding Protein 3 4
  • IL-13 Receptor Subunit Alpha-2 3 4
  • Cancer/Testis Antigen 19 2 3
  • IL-13R Subunit Alpha-2 3 4
  • IL-13R-Alpha-2 3 4
  • IL-13RA2 3 4
  • Interleukin 13 Receptor Alpha 2 Chain 3
  • Interleukin 13 Binding Protein 3
  • CD213a2 Antigen 4
  • CD213A2 3
  • IL-13R 3
  • IL13BP 3
  • IL13R 4
  • CT19 3

External Ids for IL13RA2 Gene

Previous GeneCards Identifiers for IL13RA2 Gene

  • GC0XM109214
  • GC0XM111363
  • GC0XM112274
  • GC0XM113005
  • GC0XM113006
  • GC0XM114061
  • GC0XM114238
  • GC0XM103824

Summaries for IL13RA2 Gene

Entrez Gene Summary for IL13RA2 Gene

  • The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL13RA2 Gene

IL13RA2 (Interleukin 13 Receptor Subunit Alpha 2) is a Protein Coding gene. Diseases associated with IL13RA2 include Glioblastoma Multiforme and Malignant Glioma. Among its related pathways are IL4-mediated signaling events and ERK Signaling. GO annotations related to this gene include signal transducer activity and cytokine receptor activity. An important paralog of this gene is IL5RA.

UniProtKB/Swiss-Prot for IL13RA2 Gene

  • Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).

Gene Wiki entry for IL13RA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL13RA2 Gene

Genomics for IL13RA2 Gene

Regulatory Elements for IL13RA2 Gene

Enhancers for IL13RA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL13RA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL13RA2 Gene

115,003,975 bp from pter
115,019,977 bp from pter
16,003 bases
Minus strand

Genomic View for IL13RA2 Gene

Genes around IL13RA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL13RA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL13RA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL13RA2 Gene

Proteins for IL13RA2 Gene

  • Protein details for IL13RA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-13 receptor subunit alpha-2
    Protein Accession:
    Secondary Accessions:
    • A8K7E2
    • O00667

    Protein attributes for IL13RA2 Gene

    380 amino acids
    Molecular mass:
    44176 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL13RA2 Gene

neXtProt entry for IL13RA2 Gene

Proteomics data for IL13RA2 Gene at MOPED

Post-translational modifications for IL13RA2 Gene

  • Glycosylation at Asn 115, Asn 215, Asn 290, and Asn 299

Other Protein References for IL13RA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IL13RA2 (IL-13 R alpha 2)

No data available for DME Specific Peptides for IL13RA2 Gene

Domains & Families for IL13RA2 Gene

Protein Domains for IL13RA2 Gene

Suggested Antigen Peptide Sequences for IL13RA2 Gene

Graphical View of Domain Structure for InterPro Entry



  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • The box 1 motif is required for JAK interaction and/or activation.
  • Contains 3 fibronectin type-III domains.
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
genes like me logo Genes that share domains with IL13RA2: view

Function for IL13RA2 Gene

Molecular function for IL13RA2 Gene

GENATLAS Biochemistry:
interleukin 13 receptor,alpha
UniProtKB/Swiss-Prot Function:
Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).
genes like me logo Genes that share phenotypes with IL13RA2: view

Animal Models for IL13RA2 Gene

MGI Knock Outs for IL13RA2:

Animal Model Products

miRNA for IL13RA2 Gene

miRTarBase miRNAs that target IL13RA2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL13RA2 Gene

Localization for IL13RA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL13RA2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for IL13RA2 Gene COMPARTMENTS Subcellular localization image for IL13RA2 gene
Compartment Confidence
extracellular 4
plasma membrane 3
nucleus 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL13RA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with IL13RA2: view

Pathways & Interactions for IL13RA2 Gene

genes like me logo Genes that share pathways with IL13RA2: view

Pathways by source for IL13RA2 Gene

Interacting Proteins for IL13RA2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000243213 Q14627-I13R2_HUMAN for IL13RA2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for IL13RA2 Gene


No data available for SIGNOR curated interactions for IL13RA2 Gene

Drugs & Compounds for IL13RA2 Gene

(4) Drugs for IL13RA2 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AER001 Investigational Pharma Target 0
Cintredekin Besudotox Investigational Pharma 0
AER001,AEROVANT Pharma 0

(1) Additional Compounds for IL13RA2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL13RA2: view

Transcripts for IL13RA2 Gene

mRNA/cDNA for IL13RA2 Gene

Unigene Clusters for IL13RA2 Gene

Interleukin 13 receptor, alpha 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL13RA2 Gene

No ASD Table

Relevant External Links for IL13RA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL13RA2 Gene

mRNA expression in normal human tissues for IL13RA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL13RA2 Gene

This gene is overexpressed in Artery - Aorta (x9.3), Testis (x8.9), and Brain - Hypothalamus (x5.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IL13RA2 Gene

SOURCE GeneReport for Unigene cluster for IL13RA2 Gene Hs.336046

genes like me logo Genes that share expression patterns with IL13RA2: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IL13RA2 Gene

Orthologs for IL13RA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL13RA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC616008 35
  • 82.21 (n)
  • 72.51 (a)
IL13RA2 36
  • 70 (a)
(Canis familiaris)
Mammalia IL13RA2 35
  • 82.93 (n)
  • 73.32 (a)
IL13RA2 36
  • 69 (a)
(Mus musculus)
Mammalia Il13ra2 35
  • 73.24 (n)
  • 60 (a)
Il13ra2 16
Il13ra2 36
  • 55 (a)
(Pan troglodytes)
Mammalia IL13RA2 35
  • 99.39 (n)
  • 98.42 (a)
IL13RA2 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Il13ra2 35
  • 72.3 (n)
  • 57.49 (a)
(Monodelphis domestica)
Mammalia IL13RA2 36
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia IL13RA2 36
  • 42 (a)
(Gallus gallus)
Aves IL13RA2 35
  • 52.19 (n)
  • 39.94 (a)
IL13RA2 36
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia il13ra2 35
  • 51.86 (n)
  • 37.43 (a)
(Danio rerio)
Actinopterygii il13ra2 35
  • 50 (n)
  • 39 (a)
il13ra2 36
  • 29 (a)
Species with no ortholog for IL13RA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL13RA2 Gene

Gene Tree for IL13RA2 (if available)
Gene Tree for IL13RA2 (if available)

Paralogs for IL13RA2 Gene

Paralogs for IL13RA2 Gene

genes like me logo Genes that share paralogs with IL13RA2: view

Variants for IL13RA2 Gene

Sequence variations from dbSNP and Humsavar for IL13RA2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs17095919 - 115,014,490(-) TACCA(C/T)GGCAA reference, missense
rs978206 -- 115,015,557(+) CTTTT(A/T)ATATC intron-variant
rs3795175 -- 115,008,692(+) GTGAT(C/T)TCAGA intron-variant
rs3795176 -- 115,009,063(+) TTGTT(A/G)GTGCT intron-variant
rs5946039 -- 115,010,059(+) aagga(A/T)gttac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL13RA2 Gene

Variant ID Type Subtype PubMed ID
esv33994 CNV Gain+Loss 17666407
nsv513764 CNV Insertion 21212237
nsv511667 CNV Gain 21212237
nsv516624 CNV Gain 19592680

Variation tolerance for IL13RA2 Gene

Residual Variation Intolerance Score: 23.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IL13RA2 Gene

Disorders for IL13RA2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for IL13RA2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
glioblastoma multiforme
  • adult glioblastoma multiforme
malignant glioma
  • glioma
  • astrocytic tumor
  • medulloblastoma, desmoplastic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IL13RA2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IL13RA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL13RA2 Gene

Publications for IL13RA2 Gene

  1. Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain. (PMID: 8663118) Caput D. … Ferrara P. (J. Biol. Chem. 1996) 2 3 4 23 67
  2. Interleukin 13 mediates signal transduction through interleukin 13 receptor alpha2 in pancreatic ductal adenocarcinoma: role of IL-13 Pseudomonas exotoxin in pancreatic cancer therapy. (PMID: 20068108) Shimamura T. … Puri R.K. (Clin. Cancer Res. 2010) 3 23
  3. cDNA clone, prokaryotic expression and purification of human interleukin-13 receptor [alpha]2 chain. (PMID: 18677476) Yu W. … Zeng Y. (Cancer Immunol. Immunother. 2009) 3 23
  4. Overexpression of interleukin-13 receptor-alpha2 in neuroendocrine malignant pheochromocytoma: a novel target for receptor directed anti-cancer therapy. (PMID: 19491224) Lai E.W. … Pacak K. (J. Clin. Endocrinol. Metab. 2009) 3 23
  5. A novel role of interleukin-13 receptor alpha2 in pancreatic cancer invasion and metastasis. (PMID: 19887609) Fujisawa T. … Puri R.K. (Cancer Res. 2009) 3 23

Products for IL13RA2 Gene

Sources for IL13RA2 Gene