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IL13RA2 Gene

protein-coding   GIFtS: 60
GCID: GC0XM114238

Interleukin 13 Receptor, Alpha 2

  See IL13RA2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 13 Receptor, Alpha 21 2     CT192
Cancer/Testis Antigen 191 2     IL-13R2
Interleukin-13-Binding Protein2 3     IL13BP2
IL-13R-alpha-22 3     Interleukin 13 Binding Protein2
IL-13RA22 3     Interleukin 13 Receptor Alpha 2 Chain2
IL-13 Receptor Subunit Alpha-22 3     Interleukin-13 Receptor Subunit Alpha-22
IL-13R Subunit Alpha-22 3     IL13R3
CD213A22     CD213a2 Antigen3

External Ids:    HGNC: 59751   Entrez Gene: 35982   Ensembl: ENSG000001234967   OMIM: 3001305   UniProtKB: Q146273   

Export aliases for IL13RA2 gene to outside databases

Previous GC identifers: GC0XM109214 GC0XM111363 GC0XM112274 GC0XM113005 GC0XM113006 GC0XM114061 GC0XM103824


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL13RA2 Gene:
The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex.
This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a
signal mediator. It is reported to play a role in the internalization of IL13. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL13RA2 Gene:
IL13RA2 (interleukin 13 receptor, alpha 2) is a protein-coding gene. Diseases associated with IL13RA2 include glioblastoma multiforme, and burkitt's lymphoma. GO annotations related to this gene include cytokine receptor activity and signal transducer activity. An important paralog of this gene is IL5RA.

UniProtKB/Swiss-Prot: I13R2_HUMAN, Q14627
Function: Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4)

Gene Wiki entry for IL13RA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_028405.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL13RA2 gene promoter:
         STAT1   ATF-2   CUTL1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   GATA-1   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL13RA2 promoter sequence
   Search Chromatin IP Primers for IL13RA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL13RA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq23   Ensembl cytogenetic band:  Xq23   HGNC cytogenetic band: Xq23

IL13RA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL13RA2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM114238:  view genomic region     (about GC identifiers)

Start:
114,238,538 bp from pter      End:
114,254,540 bp from pter
Size:
16,003 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: I13R2_HUMAN, Q14627 (See protein sequence)
Recommended Name: Interleukin-13 receptor subunit alpha-2 precursor  
Size: 380 amino acids; 44176 Da
1 PDB 3D structure from and Proteopedia for IL13RA2:
3LB6 (3D)    
Secondary accessions: A8K7E2 O00667

Explore the universe of human proteins at neXtProt for IL13RA2: NX_Q14627

Explore proteomics data for IL13RA2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn115, Asn215, Asn290, Asn299

  • See IL13RA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000631.1  
    ENSEMBL proteins: 
     ENSP00000361004   ENSP00000243213  

    IL13RA2 Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for IL13RA2
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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for IL13RA2 (17 products) 

     
    antibodies-online peptides for IL13RA2

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    antibodies-online antibodies for IL13RA2 (69 products) 

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    antibodies-online kits for IL13RA2 (13 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 13 receptor, alpha2
    IL-2 receptor family

    4 InterPro protein domains:
     IPR015321 IL-6_rcpt_alpha-bd
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold
     IPR003532 Short_hematopoietin_rcpt_2_CS

    Graphical View of Domain Structure for InterPro Entry Q14627

    ProtoNet protein and cluster: Q14627

    UniProtKB/Swiss-Prot: I13R2_HUMAN, Q14627
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
    transport and cell-surface receptor binding
    Domain: The box 1 motif is required for JAK interaction and/or activation
    Similarity: Belongs to the type I cytokine receptor family. Type 5 subfamily
    Similarity: Contains 3 fibronectin type-III domains


    Find genes that share domains with IL13RA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I13R2_HUMAN, Q14627
    Function: Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4)

         Genatlas biochemistry entry for IL13RA2:
    interleukin 13 receptor,alpha

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS9725226
    GO:0004896cytokine receptor activity TAS9725226
    GO:0005515protein binding ----
         
    Find genes that share ontologies with IL13RA2           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Il13ra2):
     hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with IL13RA2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Il13ra2tm1Gru for IL13RA2

       genOway: Develop your customized and physiologically relevant rodent model for IL13RA2

    miRNA
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    miRTarBase miRNAs that target IL13RA2:
    hsa-mir-148b-3p (MIRT019423), hsa-mir-26b-5p (MIRT030111)

    Block miRNA regulation of human, mouse, rat IL13RA2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IL13RA2
    SwitchGear 3'UTR luciferase reporter plasmidIL13RA2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    I13R2_HUMAN, Q14627: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane3
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS9083087
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with IL13RA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL13RA2 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    2TGF-Beta Pathway
    MAPK Family Pathway0.60
    3PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    4ERK Signaling
    Molecular Mechanisms of Cancer0.51
    5PEDF Induced Signaling
    STAT3 Pathway0.47


    Find genes that share SuperPaths with IL13RA2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL13RA2 (see all 7)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling
    Akt Signaling

    1 BioSystems Pathway for IL13RA2
        IL4-mediated signaling events



    1 Kegg Pathway  (Kegg details for IL13RA2):
        Jak-STAT signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL13RA2: 
              Fibrosis in human mouse rat
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL13RA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for IL13RA2 (Q146273 ENSP000002432134) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL4P051123, ENSP000002314494I2D: score=1 STRING: ENSP00000231449
    IL13P352253, ENSP000003049154I2D: score=2 STRING: ENSP00000304915
    STAT6ENSP000003001344STRING: ENSP00000300134
    CBLENSP000002640334STRING: ENSP00000264033
    CBLBENSP000002641224STRING: ENSP00000264122
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9725226
    GO:0019221cytokine-mediated signaling pathway TAS9725226

    Find genes that share ontologies with IL13RA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL13RA2 (I13R2)

    2 Novoseek inferred chemical compound relationships for IL13RA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 0 2 15448012 (1)
    glutamate 0 1 15448012 (1)



    Find genes that share compounds with IL13RA2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL13RA2 gene: 
    NM_000640.2  

    Unigene Cluster for IL13RA2:

    Interleukin 13 receptor, alpha 2
    Hs.336046  [show with all ESTs]
    Unigene Representative Sequence: AK308523
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371936(uc004epx.3) ENST00000468224 ENST00000243213(uc010nqd.1 uc022cdb.1)

    miRNA
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    Additional mRNA sequence: 

    AK291957.1 AK308523.1 AK309444.1 BC020739.1 BC033705.2 GQ494004.1 U70981.1 X95302.1 
    Y08768.1 

    3 DOTS entries:

    DT.210328  DT.100834188  DT.121296359 

    Selected AceView cDNA sequences (see all 50):

    AW954333 BX282434 U70981 BC033705 X95302 BQ225471 CR594473 BP369407 
    BQ432114 CD672811 CR623092 AL525497 AA621766 BF591502 BU852980 BM541457 
    BU561217 AW136614 BG778615 BX343416 Y08768 BP369844 CB269805 NM_000640 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL13RA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAAATGTT
    IL13RA2 Expression
    About this image


    IL13RA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Eye (Sensory Organs)
             Retina
     
     Testis (Reproductive System)
     
     Fibroblasts (Uncategorized)
    IL13RA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL13RA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.336046
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL13RA2: 
              Fibrosis in human mouse rat
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL13RA2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il13ra21 , 5 interleukin 13 receptor, alpha 21, 5 73.24(n)1
    60(a)1
      X (68.46 cM)5
    161651  NM_008356.31  NP_032382.11 
     1473834765 
    chicken
    (Gallus gallus)
    Aves IL13RA21 interleukin 13 receptor, alpha 2 52.19(n)
    39.94(a)
      422219  NM_001048078.1  NP_001041543.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia il13ra21 interleukin 13 receptor, alpha 2 51.86(n)
    37.43(a)
      100496319  XM_002937055.1  XP_002937101.1 
    zebrafish
    (Danio rerio)
    Actinopterygii il13ra21 interleukin 13 receptor, alpha 2 50(n)
    39(a)
      368326  NM_001113731.1  NP_001107203.1 


    ENSEMBL Gene Tree for IL13RA2 (if available)
    TreeFam Gene Tree for IL13RA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL13RA2 gene
    IL5RA2  IL13RA12  

    Find genes that share paralogs with IL13RA2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL13RA2 (see all 258)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs5386871,2
    C,F,A--114219661(-) tacacA/Ggaagg 1 -- ds50016Minor allele frequency- G:0.36NA NS WA CSA 99
    rs1859446271,2
    --114219683(+) AGGTAC/TGCGCC 1 -- ds50010--------
    rs170958631,2
    C,F--114219686(-) GGTGGC/TGCGTA 1 -- ds50012Minor allele frequency- T:0.01NS 92
    rs1907488261,2
    --114219694(+) ACCATA/GCCTGG 1 -- ds50010--------
    rs170958641,2
    C,F--114219702(-) AAAATT/CAGCCA 1 -- ds50013Minor allele frequency- C:0.07NS CSA 93
    rs170958671,2
    C,F--114219725(-) CCCCAT/GTTCTA 1 -- ds50012Minor allele frequency- G:0.01NS 92
    rs1839195861,2
    --114220157(+) AAGACA/GTATTC 1 -- ds50010--------
    rs170949941,2
    C,F--114220396(-) GCTTCA/CCTTTG 1 -- int15Minor allele frequency- C:0.10NS NA CSA 97
    rs1876894491,2
    --114220580(+) CCATCG/TCTATA 1 -- int10--------
    rs1925083221,2
    --114220672(+) CTGTAA/GTCCCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for IL13RA2 (114238538 - 114254540 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for IL13RA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv513764CNV Insertion21212237
    nsv511667CNV Gain21212237
    nsv516624CNV Gain19592680
    esv33994CNV Gain+Loss17666407

    Locus Specific Mutation Databases (LSDB): IL13RA2

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300130    OMIM disorders: --

    5 diseases for IL13RA2:    
    About MalaCards
    glioblastoma multiforme    burkitt's lymphoma    malignant glioma    kaposi's sarcoma
    medulloblastoma

    1 disease from the University of Copenhagen DISEASES database for IL13RA2:
    Malignant glioma

    Find genes that share disorders with IL13RA2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL13RA2 gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malignant glioma 69.7 6 16740728 (1), 18430795 (1), 11939409 (1), 17328684 (1) (see all 6)
    glioblastoma multiforme 69.1 5 17804706 (2), 10946814 (1), 18665158 (1), 12231526 (1)
    glioma 67.6 8 9590132 (1), 10946814 (1), 9815919 (1), 17805488 (1) (see all 6)
    asthma allergic 63.5 2 15331327 (1), 10686479 (1)
    glioblastoma 54.1 6 15803373 (2), 18677476 (1), 12816724 (1), 15047912 (1) (see all 5)
    brain tumors 51.4 3 17328684 (1), 15047912 (1), 11083073 (1)
    astrocytoma 46.2 3 18172271 (2), 18590440 (1)
    carcinoma renal cell 39.9 5 8663118 (1), 9816125 (1), 10388747 (1), 15297430 (1)
    diphtheria 39.2 1 19916021 (1)
    tumors 36.1 19 16902988 (2), 14673019 (1), 18665158 (1), 20068108 (1) (see all 13)

    Genetic Association Database (GAD): IL13RA2
    Human Genome Epidemiology (HuGE) Navigator: IL13RA2 (9 documents)

    Export disorders for IL13RA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL13RA2 gene, integrated from 10 sources (see all 197):
    (articles sorted by number of sources associating them with IL13RA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain. (PubMed id 8663118)1, 2, 3, 9 Caput D....Ferrara P. (J. Biol. Chem. 1996)
    2. IL13RA2 gene polymorphisms are associated with systemic sclerosis. (PubMed id 16981293)1, 4, 9 Granel B....Dessein A. (J. Rheumatol. 2006)
    3. Chromosome mapping and expression of the human interleukin-13 receptor. (PubMed id 9177784)1, 2, 9 Guo J.... Minvielle S. (Genomics 1997)
    4. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    5. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    6. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
    9. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3598 HGNC: 5975 AceView: IL13RA2 Ensembl:ENSG00000123496 euGenes: HUgn3598
    ECgene: IL13RA2 Kegg: 3598 H-InvDB: IL13RA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL13RA2 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/il13ra2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL13RA2 gene:
    Search GeneIP for patents involving IL13RA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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