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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL13RA2 Gene

protein-coding GIFtS: 55
GCID: GC0XM114238

interleukin 13 receptor, alpha 2

Explore 45 diseases affiliated with
IL13RA2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin 13 Receptor, Alpha 2¹ ²		CD213a2¹
CT19¹ ²		CD213A2²
IL-13R¹ ²		Cancer/Testis Antigen 19²
IL13BP¹ ²		Interleukin 13 Binding Protein²
Interleukin-13-Binding Protein² ³		Interleukin 13 Receptor Alpha 2 Chain²
IL-13R-Alpha-2¹		Interleukin-13 Receptor Subunit Alpha-2²
IL-13RA2² ³		IL13R³
IL-13 Receptor Subunit Alpha-2² ³		CD213a2 Antigen³
IL-13R Subunit Alpha-2² ³

External Ids:	HGNC: 5975¹	Entrez Gene: 3598²	Ensembl: ENSG00000123496⁷	OMIM: 300130⁵	UniProtKB: Q14627³

Export aliases for IL13RA2 gene to outside databases

Previous GC identifers: GC0XM109214 GC0XM111363 GC0XM112274 GC0XM113005 GC0XM113006 GC0XM114061 GC0XM103824

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL13RA2:

The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This

protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal

mediator. It is reported to play a role in the internalization of IL13. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: I13R2_HUMAN, Q14627

Function: Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4)

Gene Wiki entry for IL13RA2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_028405.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL13RA2 gene promoter:
STAT1 ATF-2 CUTL1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 GATA-1 MEF-2A aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IL13RA2 promoter sequence

Search SABiosciences Chromatin IP Primers for IL13RA2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL13RA2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1-q28 Ensembl cytogenetic band: Xq23 HGNC cytogenetic band: Xq13.1-q28

IL13RA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL13RA2 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM114238: view genomic region (about GC identifiers)

Start:	114,238,538 bp from pter	End:	114,254,540 bp from pter
Size:	16,003 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: I13R2_HUMAN, Q14627 (See protein sequence)

Recommended Name: Interleukin-13 receptor subunit alpha-2 precursor

Size: 380 amino acids; 44176 Da

Subcellular location: Membrane; Single-pass type I membrane protein

1 PDB 3D structure from and Proteopedia for IL13RA2:

3LB6 (3D)

Secondary accessions: A8K7E2 O00667

Explore the universe of human proteins at neXtProt for IL13RA2: NX_Q14627

IL13RA2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000631.1

ENSEMBL proteins:

ENSP00000361004 ENSP00000243213

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for IL13RA2 (IL-13 R alpha 2)
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	Novus Biologicals IL13RA2 Proteins Novus Biologicals IL13RA2 Lysates
	Sino Biological Recombinant Protein for IL13RA2
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	TAS	9083087
GO:0005625	soluble fraction	--	--
GO:0016021	integral to membrane	IEA	--

IL13RA2 for ontologies About GeneDecksing

IL13RA2 Antibody Products:

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	GenScript Custom Superior Antibodies Services for IL13RA2
	Novus Biologicals IL13RA2 Antibodies
	Search for Antibodies for IL13RA2 at Abcam
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for IL13RA2

Assay Products for IL13RA2:

	Browse Kits and Assays available from EMD Millipore
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	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL13RA2 for domains About GeneDecksing

4 InterPro domains/families:

IPR015321 IL6_recept-bd

IPR003961 Fibronectin_type3

IPR013783 Ig-like_fold

IPR003532 Short_hematopoietin_rcpt_2_CS

Graphical View of Domain Structure for InterPro Entry Q14627

ProtoNet protein and cluster: Q14627

UniProtKB/Swiss-Prot: I13R2_HUMAN, Q14627

Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular

transport and cell-surface receptor binding

Domain: The box 1 motif is required for JAK interaction and/or activation

Similarity: Belongs to the type I cytokine receptor family. Type 5 subfamily

Similarity: Contains 3 fibronectin type-III domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: I13R2_HUMAN, Q14627

Function: Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4)

Genatlas biochemistry entry for IL13RA2:

interleukin 13 receptor,alpha

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL13RA2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IL13RA2
		SwitchGear 3'UTR luciferase reporter plasmid: IL13RA2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL13RA2 (see all 7) OriGene shRNA RFP: IL13RA2 OriGene siRNA: IL13RA2
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IL13RA2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL13RA2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL13RA2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL13RA2 (NM_000640)
		Sino Biological Human cDNA Clone for IL13RA2
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL13RA2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL13RA2
		Search LifeMap BioReagents cell lines for IL13RA2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL13RA2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	TAS	9725226
GO:0004896	cytokine receptor activity	TAS	9725226

IL13RA2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Il13ra2^tm1Gru for IL13RA2
     3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Il13ra2):

hematopoietic system

homeostasis/metabolism

immune system

IL13RA2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Jak-STAT signaling pathway

Jak-STAT signaling pathway

1.00

IL4-mediated signaling events

IL4-mediated signaling events

1.00

TGF-Beta Pathway

MAPK Family Pathway

0.60

PAK Pathway

Antioxidant Action of Vitamin-C

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL13RA2 (see all 7)

	STAT3 Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	p38 Signaling
	Akt Signaling

1 BioSystems Pathway for IL13RA2

IL4-mediated signaling events

1 Kegg Pathway (Kegg details for IL13RA2):

Jak-STAT signaling pathway

IL13RA2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL13RA2

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/17 Interacting proteins for IL13RA2 (Q14627³ ENSP00000243213⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL4	P05112³, ENSP00000231449⁴	I2D: score=1 STRING: ENSP00000231449
IL13	P35225³, ENSP00000304915⁴	I2D: score=2 STRING: ENSP00000304915
STAT6	ENSP00000300134⁴	STRING: ENSP00000300134
CBL	ENSP00000264033⁴	STRING: ENSP00000264033
CBLB	ENSP00000264122⁴	STRING: ENSP00000264122

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	9725226
GO:0019221	cytokine-mediated signaling pathway	TAS	9725226

IL13RA2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL13RA2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL13RA2
2 Novoseek chemical compound relationships for IL13RA2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lysine	0	2	15448012 (1)
glutamate	0	1	15448012 (1)

Search CenterWatch for drugs/clinical trials and news about IL13RA2 / I13R2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL13RA2 gene:

NM_000640.2

Unigene Cluster for IL13RA2:

Interleukin 13 receptor, alpha 2

Hs.336046 [show with all ESTs]

Unigene Representative Sequence: AK308523

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000371936(uc004epx.3) ENST00000468224 ENST00000243213(uc010nqd.1 uc022cdb.1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL13RA2
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL13RA2 (see all 7) OriGene shRNA RFP: IL13RA2 OriGene siRNA: IL13RA2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL13RA2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL13RA2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL13RA2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL13RA2 (NM_000640)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL13RA2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL13RA2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL13RA2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL13RA2

Additional cDNA sequence:

AK291957.1 AK308523.1 AK309444.1 BC020739.1 BC033705.2 GQ494004.1 U70981.1 X95302.1

Y08768.1

3 DOTS entries:

DT.210328 DT.100834188 DT.121296359

24/50 AceView cDNA sequences (see all 50):

BX282434 CD672811 U70981 BP369407 BQ432114 BC033705 AW954333 X95302

BQ225471 CR623092 CR594473 BG723203 BX343416 AL525497 AA298563 BU852980

Y08768 BU927742 BU561217 AA621766 BM541457 BF591502 AA909507 CB269805

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL13RA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCAAATGTT

About this image

IL13RA2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Respiratory Bronchioles

Basal Cells

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Dorsal forebrain-like neurons (Generation of midbra...)

Brain

See IL13RA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL13RA2

SOURCE GeneReport for Unigene cluster: Hs.336046

SABiosciences Expression via Pathway-Focused PCR Arrays including IL13RA2:

Fibrosis in human mouse rat

Interferons & Receptors in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Allergy & Asthma in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL13RA2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL13RA2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL13RA2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL13RA2 gene from 2/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	IL13RA2¹	interleukin 13 receptor, alpha 2	53.05(n) 41.46(a)		422219 NM_001048078.1 NP_001041543.1
zebrafish (Danio rerio)	Actinopterygii	il13ra2¹	interleukin 13 receptor, alpha 2	49.78(n) 38.39(a)		368326 NM_001113731.1 NP_001107203.1

ENSEMBL Gene Tree for IL13RA2 (if available)
TreeFam Gene Tree for IL13RA2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IL13RA2 gene

IL5RA² IL13RA1²

IL13RA2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185944627^1,2		--	114238059(+)	`AGGTAC/TGCGCC`	1	--	ds500¹		0	--	--	--	--
rs17095863^1,2	C,F,	--	114238062(-)	`GGTGGC/TGCGTA`	1	--	ds500¹		2		NS	92
rs190748826^1,2		--	114238070(+)	`ACCATA/GCCTGG`	1	--	ds500¹		0	--	--	--	--
rs17095864^1,2	C,F,	--	114238078(-)	`AAAATT/CAGCCA`	1	--	ds500¹		3		NS CSA	93
rs17095867^1,2	C,F,	--	114238101(-)	`CCCCAT/GTTCTA`	1	--	ds500¹		2		NS	92
rs17095491^1,2	C,F,	--	114238317(-)	`ACAGAGA/-TATTG`	1	--	ds500¹		2		NS	84
rs183919586^1,2		--	114238535(+)	`AAGACA/GTATTC`	1	--	ds500¹		0	--	--	--	--
rs17094994^1,2	C,F,	--	114238774(-)	`GCTTCA/CCTTTG`	1	--	int¹		5		NS NA CSA	97
rs187689449^1,2		--	114238958(+)	`CCATCG/TCTATA`	1	--	int¹		0	--	--	--	--
rs192508322^1,2		--	114239050(+)	`CTGTAA/GTCCCA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IL13RA2 (114238538 - 114254540 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for IL13RA2
2 CNVs: 7758 52912
Locus Specific Mutation Databases (LSDB): IL13RA2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL13RA2

DNA2.0 Custom Variant and Variant Library Synthesis for IL13RA2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL13RA2 for disorders           About GeneDecksing

OMIM gene information: 300130    OMIM disorders: --

20/45 diseases for IL13RA2 (see all 45):    About MalaCards

nonalcoholic steatohepatitis allergic rhinitis idiopathic interstitial pneumonia burkitt's lymphoma

kaposi's sarcoma malignant glioma diphtheria pancreatic ductal adenocarcinoma

rhinitis ulcerative colitis bronchiolitis mastocytosis

renal cell carcinoma cblc medulloblastoma asthma

glioblastoma ovarian cancer sarcoma pneumonia

1 disease from the University of Copenhagen DISEASES database for IL13RA2:

Malignant glioma

10/26 Novoseek disease relationships for IL13RA2 gene (see all 26) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
malignant glioma	69.7	6	16740728 (1), 18430795 (1), 11939409 (1), 17328684 (1) (see all 6)
glioblastoma multiforme	69.1	5	17804706 (2), 10946814 (1), 18665158 (1), 12231526 (1)
glioma	67.6	8	9590132 (1), 10946814 (1), 9815919 (1), 17805488 (1) (see all 6)
asthma allergic	63.5	2	15331327 (1), 10686479 (1)
glioblastoma	54.1	6	15803373 (2), 18677476 (1), 12816724 (1), 15047912 (1) (see all 5)
brain tumors	51.4	3	17328684 (1), 15047912 (1), 11083073 (1)
astrocytoma	46.2	3	18172271 (2), 18590440 (1)
carcinoma renal cell	39.9	5	8663118 (1), 9816125 (1), 10388747 (1), 15297430 (1)
diphtheria	39.2	1	19916021 (1)
tumors	36.1	19	16902988 (2), 14673019 (1), 18665158 (1), 20068108 (1) (see all 13)

Human Genome Epidemiology (HuGE) Navigator: IL13RA2 (9 documents)

Export disorders for IL13RA2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IL13RA2 gene, integrated from 9 sources (see all 195):
(articles sorted by number of sources associating them with IL13RA2)

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Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain. (PubMed id 8663118)^{1, 2, 3, 9} Caput D....Ferrara P. (1996)
Chromosome mapping and expression of the human interleukin-13 receptor. (PubMed id 9177784)^{1, 2, 9} Guo J.... Minvielle S. (1997)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains. (PubMed id 9083087)^{1, 3} Zhang J.G....Nicola N.A. (1997)
Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy. (PubMed id 16902988)^{1, 9} Kioi M....Puri R.K. (2006)
IL13RA2 gene polymorphisms are associated with systemic sclerosis. (PubMed id 16981293)^{1, 9} Granel B....Dessein A. (2006)
Interleukin 13 mediates signal transduction through i nterleukin 13 receptor alpha2 in pancreatic ductal adenocarcinoma: role of IL-1 3 Pseudomonas exotoxin in pancreatic cancer therapy. (PubMed id 20068108)^{1, 9} Shimamura T....Puri R.K. (2010)
cDNA clone, prokaryotic expression and purification of human interleukin-13 receptor [alpha]2 chain. (PubMed id 18677476)^{1, 9} Yu W....Zeng Y. (2009)
A novel role of interleukin-13 receptor alpha2 in pan creatic cancer invasion and metastasis. (PubMed id 19887609)^{1, 9} Fujisawa T....Puri R.K. (2009)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3598	HGNC: 5975	AceView: IL13RA2	Ensembl:ENSG00000123496	euGenes: HUgn3598
ECgene: IL13RA2	Kegg: 3598	H-InvDB: IL13RA2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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Name	Description
PharmGKB entry for IL13RA2	Pharmacogenomics, SNPs, Pathways
SeattleSNPs	http://pga.gs.washington.edu/data/il13ra2/

Intellectual Property for IL13RA2 gene
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Patent Information for IL13RA2 gene:
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interleukin 13 receptor, alpha 2

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IL13RA2 Gene

interleukin 13 receptor, alpha 2

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