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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL13RA1 Gene

protein-coding   GIFtS: 60
GCID: GC0XP117861

Interleukin 13 Receptor, Alpha 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 13 Receptor, Alpha 11 2     IL-13R Subunit Alpha-12 3
CD213a1 Antigen1 2 3     CD213A12
IL13 Receptor Alpha-1 Chain1 2     IL-13Ra2
Cancer/Testis Antigen 192 3     NR42
CT192 3     BB128O4.2.1 (Interleukin 13 Receptor, Alpha 1)2
IL-13R-alpha-12 3     Interleukin-13 Receptor Subunit Alpha-12
IL-13RA12 3     IL13R3
IL-13 Receptor Subunit Alpha-12 3     IL13RA3

External Ids:    HGNC: 59741   Entrez Gene: 35972   Ensembl: ENSG000001317247   OMIM: 3001195   UniProtKB: P785523   

Export aliases for IL13RA1 gene to outside databases

Previous GC identifers: GC0XP112851 GC0XP114847 GC0XP115836 GC0XP116615 GC0XP117643 GC0XP117745 GC0XP107355


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL13RA1 Gene:
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor
complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary
IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been
shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of
JAK1, STAT3 and STAT6 induced by IL13 and IL4. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL13RA1 Gene: 
IL13RA1 (interleukin 13 receptor, alpha 1) is a protein-coding gene. Diseases associated with IL13RA1 include malignant glioma, and anaplastic astrocytoma, and among its related super-pathways are STAT3 Pathway and Akt Signaling. GO annotations related to this gene include cytokine receptor activity and protein binding. An important paralog of this gene is IL13RA2.

UniProtKB/Swiss-Prot: I13R1_HUMAN, P78552
Function: Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for
IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4
(IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding
activity

Gene Wiki entry for IL13RA1 (Interleukin 13 receptor, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011786.16  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL13RA1 gene promoter:
         c-Fos   STAT1   NF-1   NF-1/L   AML1a   YY1   HNF-4alpha1   JunD   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL13RA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL13RA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL13RA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq24

IL13RA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL13RA1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP117861:  view genomic region     (about GC identifiers)

Start:
117,861,535 bp from pter      End:
117,928,502 bp from pter
Size:
66,968 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: I13R1_HUMAN, P78552 (See protein sequence)
Recommended Name: Interleukin-13 receptor subunit alpha-1 precursor  
Size: 427 amino acids; 48760 Da
Subunit: Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with
TRAF3IP1
Subcellular location: Membrane; Single-pass type I membrane protein
3 PDB 3D structures from and Proteopedia for IL13RA1:
3BPN (3D)        3BPO (3D)        4HWB (3D)    
Secondary accessions: O95646 Q5JSL4 Q99656

Explore the universe of human proteins at neXtProt for IL13RA1: NX_P78552

Explore proteomics data for IL13RA1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P78552

  • IL13RA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL13RA1 Protein Expression
    REFSEQ proteins: NP_001551.1  
    ENSEMBL proteins: 
     ENSP00000360730   ENSP00000360705   ENSP00000360700  

    Human Recombinant Protein Products for IL13RA1: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS9083087
    GO:0005898interleukin-13 receptor complex TAS9013879
    GO:0016020membrane ----

    IL13RA1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 13 receptor, α1 
    IL-2 receptor family

    4 InterPro protein domains:
     IPR015321 IL6_recept-bd
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold
     IPR003532 Short_hematopoietin_rcpt_2_CS

    Graphical View of Domain Structure for InterPro Entry P78552

    ProtoNet protein and cluster: P78552

    1 Blocks protein domain: IPB003532 Short hematopoietin receptor

    UniProtKB/Swiss-Prot: I13R1_HUMAN, P78552
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
    transport and cell-surface receptor binding
    Domain: The box 1 motif is required for JAK interaction and/or activation
    Similarity: Belongs to the type I cytokine receptor family. Type 5 subfamily


    IL13RA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I13R1_HUMAN, P78552
    Function: Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for
    IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4
    (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding
    activity

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004896cytokine receptor activity IEA--
    GO:0005515protein binding IPI12935900
         
    IL13RA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IL13RA1:
     Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Il13ra1):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  no phenotypic analysis 
     respiratory system 

    IL13RA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IL13RA1: Il13ra1tm1Zagh Il13ra1tm1Twy

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL13RA1 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    2Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    3Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
    IL-4 Signaling Pathways0.84
    4TGF-Beta Pathway
    MAPK Family Pathway0.60
    5PAK Pathway
    Antioxidant Action of Vitamin-C0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL13RA1
        IL-4 Signaling Pathways

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL13RA1 (see all 7)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling
    Akt Signaling

    2 BioSystems Pathways for IL13RA1
        IL-4 signaling Pathway
    IL4-mediated signaling events



    2         Kegg Pathways  (Kegg details for IL13RA1):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway


    IL13RA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL13RA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/25 Interacting proteins for IL13RA1 (P785521, 3 ENSP000003607304) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL4P051121, 3, ENSP000002314494EBI-1391535,EBI-367025 I2D: score=1 STRING: ENSP00000231449
    IL13P352251, 3, ENSP000003049154EBI-1391535,EBI-1647828 I2D: score=3 STRING: ENSP00000304915
    TRAF3IP1Q8TDR01, 3, ENSP000003624244EBI-1391535,EBI-928811 I2D: score=3 STRING: ENSP00000362424
    TYK2P295973, ENSP000002648184I2D: score=3 STRING: ENSP00000264818
    IL4RP243943, ENSP000001706304I2D: score=3 STRING: ENSP00000170630
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS9013879

    IL13RA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL13RA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL13RA1 (I13R1)

    5 Novoseek inferred chemical compound relationships for IL13RA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    exotoxin-a 46.4 1 8639793 (1)
    tyrosine 11.2 3 10641437 (1), 10611490 (1)
    vegf 3.58 3 9407626 (1), 19659863 (1)
    thymidine 0 4 17392323 (1)
    nitric oxide 0 1 9407626 (1)

    Search CenterWatch for drugs/clinical trials and news about IL13RA1 / I13R1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL13RA1 gene: 
    NM_001560.2  

    Unigene Cluster for IL13RA1:

    Interleukin 13 receptor, alpha 1
    Hs.496646  [show with all ESTs]
    Unigene Representative Sequence: Y10659
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371666(uc004eqs.3) ENST00000371642(uc004eqr.1) ENST00000481868
    ENST00000371637
    miRNA
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    Additional mRNA sequence: 

    AB209849.1 AK123515.1 AK296958.1 AK313467.1 BC009960.2 BC015768.1 U81379.3 U81380.2 
    Y09328.1 Y10659.1 

    13 DOTS entries:

    DT.91712774  DT.455751  DT.86839825  DT.75102215  DT.91847097  DT.95294102  DT.91741367  DT.95087974 
    DT.100034758  DT.100818994  DT.312623  DT.95216823  DT.91814556 

    24/338 AceView cDNA sequences (see all 338):

    NM_001560 AA293316 CR603161 AA411324 BM852893 AI623147 AA127390 AW613581 
    BU522107 AI625760 CA389226 CA944522 AI139508 CB136808 AL043521 BU619294 
    BQ447053 AI359423 AU185760 AI367605 AW008384 BU608413 AW105520 CB119533 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for IL13RA1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                            -           -                       -                           
    SP2:                                                        -                                                   
    SP3:                                            -                                                               
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for IL13RA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL13RA1 expression in normal human tissues (normalized intensities)      IL13RA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTCTGGGA
    IL13RA1 Expression
    About this image


    IL13RA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
             leukocytes   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             visceral organ/lung/right lung   
     
     Esophagus (Gastrointestinal Tract)
             esophageal epithelium   
     
     Heart (Cardiovascular System)
             Dorsal Aorta
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros

    See IL13RA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL13RA1

    SOURCE GeneReport for Unigene cluster: Hs.496646

    UniProtKB/Swiss-Prot: I13R1_HUMAN, P78552
    Tissue specificity: Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain,
    lung and kidney. Also found in B-cells, T-cells and endothelial cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including IL13RA1: 
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              Th1/Th2 Response in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL13RA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL13RA1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il13ra11 , 5 interleukin 13 receptor, alpha 11, 5 82.11(n)1
    75.41(a)1
      X (20.49 cM)5
    161641  NM_133990.41  NP_598751.31 
     361121105 
    chicken
    (Gallus gallus)
    Aves IL13RA11 interleukin 13 receptor, alpha 1 51.2(n)
    37.95(a)
      422230  XM_420218.2  XP_420218.2 
    zebrafish
    (Danio rerio)
    Actinopterygii il13ra26
    interleukin 13 receptor, alpha 2
    16(a)
    1 → many
    5(38701556-38717941)


    ENSEMBL Gene Tree for IL13RA1 (if available)
    TreeFam Gene Tree for IL13RA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IL13RA1 gene
    IL13RA22  IL5RA2  

    IL13RA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1006 SNPs in IL13RA1 are shown (see all 1006)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1883750011,2
    C--117855009(+) TATTTA/TTTTTT 1 -- us2k10--------
    rs1114153931,2
    C,F--117855025(+) GAGAAT/CGGGGT 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1121768911,2
    C,F--117855271(+) AATTCT/CTTGTT 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs24956371,2
    C,F,O,A,H--117855338(+) TTTTGA/GTGAGT 1 -- us2k124Minor allele frequency- N:0.00EA NA NS CSA 2552
    rs19372711,2
    C,F,A,H--117855386(+) ATTGAA/GTTTGA 1 -- us2k113Minor allele frequency- G:0.05NS EA WA NA CSA 434
    rs1849526451,2
    --117855512(+) AACTGC/TTTTCA 1 -- us2k10--------
    rs1388011501,2
    --117855699(+) AGTTAC/TGATTA 1 -- us2k10--------
    rs1909753871,2
    --117855946(+) CACACC/TTTGAT 1 -- us2k10--------
    rs1809740801,2
    --117856081(+) CCAGCC/TTCACT 1 -- us2k10--------
    rs1419930271,2
    --117856172(+) TCGTGC/TGCTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL13RA1 (117861535 - 117928502 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IL13RA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1709061CNV Insertion17803354
    dgv527n21CNV Gain19592680


    Locus Specific Mutation Databases (LSDB): IL13RA1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IL13RA1
    DNA2.0 Custom Variant and Variant Library Synthesis for IL13RA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300119    OMIM disorders: --

    20/29 diseases for IL13RA1 (see all 29):    About MalaCards
    malignant glioma    anaplastic astrocytoma    idiopathic interstitial pneumonia    atopy
    pneumonia    cblc    glioblastoma    astrocytoma
    nephrotic syndrome    ulcerative colitis    atopic dermatitis    bronchiolitis
    hodgkin's lymphoma    asthma    pituitary adenoma    non-hodgkin lymphoma
    dermatitis    psoriasis    cervical cancer    adenoma


    IL13RA1 for disorders           About GeneDecksing

    10/17 Novoseek inferred disease relationships for IL13RA1 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma allergic 63.6 3 17006604 (3)
    glioblastoma multiforme 56.7 2 12939468 (1), 17398005 (1)
    malignant glioma 54.5 3 10728667 (1), 12481422 (1), 15329913 (1)
    glioma 45.2 5 15329913 (1), 15803373 (1), 12939468 (1), 9407626 (1) (see all 5)
    asthma 37.3 9 10699178 (2), 17392323 (2), 17006604 (2), 17287216 (1) (see all 5)
    atopy 36.4 5 10699178 (1), 17392323 (1)
    brain tumors 35.6 3 10728667 (1), 15838375 (1), 11939409 (1)
    pneumonia interstitial 32.7 1 15161635 (1)
    anaplastic astrocytoma 32.1 1 12939468 (1)
    glioblastoma 31.3 1 15803373 (1)

    Genetic Association Database (GAD): IL13RA1
    Human Genome Epidemiology (HuGE) Navigator: IL13RA1 (13 documents)

    Export disorders for IL13RA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL13RA1 gene, integrated from 9 sources (see all 141):
    (articles sorted by number of sources associating them with IL13RA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex. (PubMed id 9013879)1, 2, 3 Miloux B....Ferrara P. (1997)
    2. cDNA cloning and characterization of the human interleukin 13 receptor alpha chain. (PubMed id 8910586)1, 2, 3 Aman M.J.... Leonard W.J. (1996)
    3. Gene-gene interaction between IL-13 and IL-13Ralpha1 is associated with total IgE in Korean children with atopic asthma. (PubMed id 17006604)1, 4, 9 Kim H.B....Hong S.J. (2006)
    4. Genetic association studies of interleukin-13 receptor alpha1 subunit gene polymorphisms in asthma and atopy. (PubMed id 17392323)1, 4, 9 Konstantinidis A.K....Holloway J.W. (2007)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    8. Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. (PubMed id 18243101)1, 2 LaPorte S.L.... Garcia K.C. (2008)
    9. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3597 HGNC: 5974 AceView: IL13RA1 Ensembl:ENSG00000131724 euGenes: HUgn3597
    ECgene: IL13RA1 Kegg: 3597 H-InvDB: IL13RA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL13RA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL13RA1 gene:
    Search GeneIP for patents involving IL13RA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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