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Aliases for IL13RA1 Gene

Aliases for IL13RA1 Gene

  • Interleukin 13 Receptor Subunit Alpha 1 2 3 5
  • CD213a1 Antigen 2 3 4
  • Interleukin 13 Receptor, Alpha 1 2 3
  • IL-13 Receptor Subunit Alpha-1 3 4
  • IL13 Receptor Alpha-1 Chain 2 3
  • Cancer/Testis Antigen 19 3 4
  • IL-13R Subunit Alpha-1 3 4
  • CT19 3 4
  • IL-13R-Alpha-1 4
  • IL-13RA1 4
  • CD213A1 3
  • IL-13Ra 3
  • IL13RA 4
  • IL13R 4
  • NR4 3

External Ids for IL13RA1 Gene

Previous GeneCards Identifiers for IL13RA1 Gene

  • GC0XP112851
  • GC0XP114847
  • GC0XP115836
  • GC0XP116615
  • GC0XP117643
  • GC0XP117745
  • GC0XP117861
  • GC0XP107355

Summaries for IL13RA1 Gene

Entrez Gene Summary for IL13RA1 Gene

  • The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL13RA1 Gene

IL13RA1 (Interleukin 13 Receptor Subunit Alpha 1) is a Protein Coding gene. Diseases associated with IL13RA1 include idiopathic interstitial pneumonia and atopy. Among its related pathways are ERK Signaling and Akt Signaling. GO annotations related to this gene include interleukin-13 receptor activity. An important paralog of this gene is IL5RA.

UniProtKB/Swiss-Prot for IL13RA1 Gene

  • Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.

Gene Wiki entry for IL13RA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL13RA1 Gene

Genomics for IL13RA1 Gene

Regulatory Elements for IL13RA1 Gene

Promoters for IL13RA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IL13RA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL13RA1 Gene

Chromosome:
X
Start:
118,726,954 bp from pter
End:
118,794,539 bp from pter
Size:
67,586 bases
Orientation:
Plus strand

Genomic View for IL13RA1 Gene

Genes around IL13RA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL13RA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL13RA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL13RA1 Gene

Proteins for IL13RA1 Gene

  • Protein details for IL13RA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78552-I13R1_HUMAN
    Recommended name:
    Interleukin-13 receptor subunit alpha-1
    Protein Accession:
    P78552
    Secondary Accessions:
    • O95646
    • Q5JSL4
    • Q99656
    • Q9UDY5

    Protein attributes for IL13RA1 Gene

    Size:
    427 amino acids
    Molecular mass:
    48760 Da
    Quaternary structure:
    • Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1.

    Three dimensional structures from OCA and Proteopedia for IL13RA1 Gene

    Alternative splice isoforms for IL13RA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL13RA1 Gene

Proteomics data for IL13RA1 Gene at MOPED

Post-translational modifications for IL13RA1 Gene

  • Ubiquitination at Lys 386
  • Glycosylation at Asn 37, Asn 61, Asn 105, Asn 138, Asn 157, Asn 235, Asn 265, Asn 293, Asn 329, and Asn 341
  • Modification sites at PhosphoSitePlus

Other Protein References for IL13RA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IL13RA1 (IL-13 R alpha 1)

No data available for DME Specific Peptides for IL13RA1 Gene

Domains & Families for IL13RA1 Gene

Graphical View of Domain Structure for InterPro Entry

P78552

UniProtKB/Swiss-Prot:

I13R1_HUMAN :
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • The box 1 motif is required for JAK interaction and/or activation.
  • Contains 3 fibronectin type-III domains.
Family:
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
genes like me logo Genes that share domains with IL13RA1: view

Function for IL13RA1 Gene

Molecular function for IL13RA1 Gene

UniProtKB/Swiss-Prot Function:
Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
genes like me logo Genes that share phenotypes with IL13RA1: view

Animal Models for IL13RA1 Gene

MGI Knock Outs for IL13RA1:

Animal Model Products

miRNA for IL13RA1 Gene

miRTarBase miRNAs that target IL13RA1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL13RA1 Gene

Localization for IL13RA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL13RA1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL13RA1 Gene COMPARTMENTS Subcellular localization image for IL13RA1 gene
Compartment Confidence
plasma membrane 5
nucleus 3
extracellular 2
golgi apparatus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL13RA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 9083087
GO:0005898 interleukin-13 receptor complex TAS 9013879
genes like me logo Genes that share ontologies with IL13RA1: view

Pathways & Interactions for IL13RA1 Gene

genes like me logo Genes that share pathways with IL13RA1: view

Pathways by source for IL13RA1 Gene

2 BioSystems pathways for IL13RA1 Gene
1 R&D Systems pathway for IL13RA1 Gene

SIGNOR curated interactions for IL13RA1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL13RA1 Gene

None

Drugs & Compounds for IL13RA1 Gene

(5) Drugs for IL13RA1 Gene - From: Novoseek and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cintredekin Besudotox Investigational Pharma 0
AER001,AEROVANT Pharma 0

(2) Additional Compounds for IL13RA1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL13RA1: view

Transcripts for IL13RA1 Gene

Unigene Clusters for IL13RA1 Gene

Interleukin 13 receptor, alpha 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL13RA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for IL13RA1 Gene

GeneLoc Exon Structure for
IL13RA1
ECgene alternative splicing isoforms for
IL13RA1

Expression for IL13RA1 Gene

mRNA expression in normal human tissues for IL13RA1 Gene

Protein differential expression in normal tissues from HIPED for IL13RA1 Gene

This gene is overexpressed in Cervix (35.7) and Serum (33.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IL13RA1 Gene



SOURCE GeneReport for Unigene cluster for IL13RA1 Gene Hs.496646

mRNA Expression by UniProt/SwissProt for IL13RA1 Gene

P78552-I13R1_HUMAN
Tissue specificity: Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.
genes like me logo Genes that share expression patterns with IL13RA1: view

Protein tissue co-expression partners for IL13RA1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for IL13RA1 Gene

Orthologs for IL13RA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL13RA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL13RA1 35
  • 88.6 (n)
  • 87.03 (a)
IL13RA1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL13RA1 35
  • 88.91 (n)
  • 85.71 (a)
IL13RA1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il13ra1 35
  • 81.95 (n)
  • 75.18 (a)
Il13ra1 16
Il13ra1 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL13RA1 35
  • 99.53 (n)
  • 99.06 (a)
IL13RA1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il13ra1 35
  • 81.8 (n)
  • 74.94 (a)
oppossum
(Monodelphis domestica)
Mammalia IL13RA1 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL13RA1 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL13RA1 35
  • 51.35 (n)
  • 38.65 (a)
IL13RA1 36
  • 32 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il13ra1 35
  • 46.61 (n)
  • 34.11 (a)
Species with no ortholog for IL13RA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL13RA1 Gene

ENSEMBL:
Gene Tree for IL13RA1 (if available)
TreeFam:
Gene Tree for IL13RA1 (if available)

Paralogs for IL13RA1 Gene

Paralogs for IL13RA1 Gene

genes like me logo Genes that share paralogs with IL13RA1: view

Variants for IL13RA1 Gene

Sequence variations from dbSNP and Humsavar for IL13RA1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs11137 -- 118,794,412(-) GTGCC(A/C)AGATG utr-variant-3-prime
rs1316954 -- 118,756,493(-) AAACA(C/T)AATGG intron-variant
rs1316982 -- 118,753,835(+) CATAT(A/T)CAGTC intron-variant
rs1892299 -- 118,743,474(-) ACTGC(C/T)TAAAA intron-variant
rs1937269 -- 118,776,536(-) CATTT(A/C/T)AAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL13RA1 Gene

Variant ID Type Subtype PubMed ID
dgv527n21 CNV Gain 19592680
esv1709061 CNV Insertion 17803354

Variation tolerance for IL13RA1 Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL13RA1 Gene

HapMap Linkage Disequilibrium report
IL13RA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL13RA1 Gene

Disorders for IL13RA1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for IL13RA1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
idiopathic interstitial pneumonia
  • idiopathic pulmonary fibrosis
atopy
  • atopic hypersensitivity
oral cavity cancer
  • malignant neoplasm of anterior portion of floor of mouth
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for IL13RA1

Genetic Association Database (GAD)
IL13RA1
Human Genome Epidemiology (HuGE) Navigator
IL13RA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL13RA1
genes like me logo Genes that share disorders with IL13RA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL13RA1 Gene

Publications for IL13RA1 Gene

  1. Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex. (PMID: 9013879) Miloux B. … Ferrara P. (FEBS Lett. 1997) 2 3 4 67
  2. Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness. (PMID: 19586918) Ito T. … Izuhara K. (J. Biol. Chem. 2009) 3 23
  3. Interleukin-13 and its receptors in idiopathic interstitial pneumonia: clinical implications for lung function. (PMID: 19654941) Park S.W. … Park C.S. (J. Korean Med. Sci. 2009) 3 23
  4. Genetic association studies of interleukin-13 receptor alpha1 subunit gene polymorphisms in asthma and atopy. (PMID: 17392323) Konstantinidis A.K. … Holloway J.W. (Eur. Respir. J. 2007) 3 23
  5. Mast cells express IL-13R alpha 1: IL-13 promotes human lung mast cell proliferation and Fc epsilon RI expression. (PMID: 16918506) Kaur D. … Brightling C.E. (Allergy 2006) 3 23

Products for IL13RA1 Gene

Sources for IL13RA1 Gene

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