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IL13RA1 Gene

protein-coding   GIFtS: 61
GCID: GC0XP117861

Interleukin 13 Receptor, Alpha 1

  See IL13RA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 13 Receptor, Alpha 11 2     IL-13R Subunit Alpha-12 3
CD213a1 Antigen1 2 3     CD213A12
IL13 Receptor Alpha-1 Chain1 2     IL-13Ra2
Cancer/Testis Antigen 192 3     NR42
CT192 3     BB128O4.2.1 (Interleukin 13 Receptor, Alpha 1)2
IL-13R-alpha-12 3     Interleukin-13 Receptor Subunit Alpha-12
IL-13RA12 3     IL13R3
IL-13 Receptor Subunit Alpha-12 3     IL13RA3

External Ids:    HGNC: 59741   Entrez Gene: 35972   Ensembl: ENSG000001317247   OMIM: 3001195   UniProtKB: P785523   

Export aliases for IL13RA1 gene to outside databases

Previous GC identifers: GC0XP112851 GC0XP114847 GC0XP115836 GC0XP116615 GC0XP117643 GC0XP117745 GC0XP107355


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL13RA1 Gene:
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor
complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary
IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been
shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of
JAK1, STAT3 and STAT6 induced by IL13 and IL4. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL13RA1 Gene:
IL13RA1 (interleukin 13 receptor, alpha 1) is a protein-coding gene. Diseases associated with IL13RA1 include malignant glioma, and atopy. GO annotations related to this gene include cytokine receptor activity. An important paralog of this gene is IL13RA2.

UniProtKB/Swiss-Prot: I13R1_HUMAN, P78552
Function: Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for
IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4
(IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding
activity

Gene Wiki entry for IL13RA1 (Interleukin 13 receptor, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011786.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL13RA1 gene promoter:
         c-Fos   STAT1   NF-1   NF-1/L   AML1a   YY1   HNF-4alpha1   JunD   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL13RA1 promoter sequence
   Search Chromatin IP Primers for IL13RA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL13RA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq24

IL13RA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL13RA1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP117861:  view genomic region     (about GC identifiers)

Start:
117,861,535 bp from pter      End:
117,928,502 bp from pter
Size:
66,968 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: I13R1_HUMAN, P78552 (See protein sequence)
Recommended Name: Interleukin-13 receptor subunit alpha-1 precursor  
Size: 427 amino acids; 48760 Da
Subunit: Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with
TRAF3IP1
3 PDB 3D structures from and Proteopedia for IL13RA1:
3BPN (3D)        3BPO (3D)        4HWB (3D)    
Secondary accessions: O95646 Q5JSL4 Q99656

Explore the universe of human proteins at neXtProt for IL13RA1: NX_P78552

Explore proteomics data for IL13RA1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys386
  • Glycosylation2 at Asn37, Asn61, Asn105, Asn138, Asn157, Asn235, Asn265, Asn293, Asn329, Asn341
  • Modification sites at PhosphoSitePlus

  • See IL13RA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001551.1  
    ENSEMBL proteins: 
     ENSP00000360730   ENSP00000360705   ENSP00000360700  

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    antibodies-online proteins for IL13RA1 (26 products) 

     
    antibodies-online peptides for IL13RA1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 13 receptor, alpha1
    IL-2 receptor family

    4 InterPro protein domains:
     IPR015321 IL-6_rcpt_alpha-bd
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold
     IPR003532 Short_hematopoietin_rcpt_2_CS

    Graphical View of Domain Structure for InterPro Entry P78552

    ProtoNet protein and cluster: P78552

    1 Blocks protein domain: IPB003532 Short hematopoietin receptor

    UniProtKB/Swiss-Prot: I13R1_HUMAN, P78552
    Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular
    transport and cell-surface receptor binding
    Domain: The box 1 motif is required for JAK interaction and/or activation
    Similarity: Belongs to the type I cytokine receptor family. Type 5 subfamily
    Similarity: Contains 3 fibronectin type-III domains


    Find genes that share domains with IL13RA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I13R1_HUMAN, P78552
    Function: Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for
    IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4
    (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding
    activity

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004896cytokine receptor activity ----
    GO:0005515protein binding IPI12935900
    GO:0016515interleukin-13 receptor activity IEA--
         
    Find genes that share ontologies with IL13RA1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IL13RA1:
     Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Il13ra1):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  no phenotypic analysis 
     respiratory system 

    Find genes that share phenotypes with IL13RA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IL13RA1: Il13ra1tm1Zagh Il13ra1tm1Twy

       genOway: Develop your customized and physiologically relevant rodent model for IL13RA1

    miRNA
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    miRTarBase miRNAs that target IL13RA1:
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    Selected qRT-PCR Assays for microRNAs that regulate IL13RA1 (see all 26):
    hsa-miR-4286 hsa-miR-4311 hsa-miR-188-5p hsa-miR-4328 hsa-miR-513c hsa-miR-515-5p hsa-miR-649 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidIL13RA1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    I13R1_HUMAN, P78552: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS9083087
    GO:0005898interleukin-13 receptor complex TAS9013879
    GO:0016020membrane ----

    Find genes that share ontologies with IL13RA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL13RA1 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    2Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    3IL-9 Signaling Pathways
    IL-4 Signaling Pathways0.84
    4TGF-Beta Pathway
    MAPK Family Pathway0.60
    5PAK Pathway
    Antioxidant Action of Vitamin-C0.56


    Find genes that share SuperPaths with IL13RA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL13RA1
        IL-4 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL13RA1 (see all 7)
        STAT3 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    p38 Signaling
    Akt Signaling

    2 BioSystems Pathways for IL13RA1
        IL-4 signaling Pathway
    IL4-mediated signaling events



    2 Kegg Pathways  (Kegg details for IL13RA1):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL13RA1: 
              Interferons & Receptors in human mouse rat
              Th1/Th2 Response in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL13RA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for IL13RA1 (P785521, 3 ENSP000003607304) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL4P051121, 3, ENSP000002314494EBI-1391535,EBI-367025 I2D: score=1 STRING: ENSP00000231449
    IL13P352251, 3, ENSP000003049154EBI-1391535,EBI-1647828 I2D: score=3 STRING: ENSP00000304915
    TRAF3IP1Q8TDR01, 3, ENSP000003624244EBI-1391535,EBI-928811 I2D: score=3 STRING: ENSP00000362424
    TYK2P295973, ENSP000002648184I2D: score=3 STRING: ENSP00000264818
    IL4RP243943, ENSP000001706304I2D: score=3 STRING: ENSP00000170630
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002639positive regulation of immunoglobulin production IEA--
    GO:0007166cell surface receptor signaling pathway TAS9013879
    GO:0030890positive regulation of B cell proliferation IEA--
    GO:0035772interleukin-13-mediated signaling pathway ----

    Find genes that share ontologies with IL13RA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL13RA1 (I13R1)

    5 Novoseek inferred chemical compound relationships for IL13RA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    exotoxin-a 46.4 1 8639793 (1)
    tyrosine 11.2 3 10641437 (1), 10611490 (1)
    vegf 3.58 3 9407626 (1), 19659863 (1)
    thymidine 0 4 17392323 (1)
    nitric oxide 0 1 9407626 (1)



    Find genes that share compounds with IL13RA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL13RA1 gene: 
    NM_001560.2  

    Unigene Cluster for IL13RA1:

    Interleukin 13 receptor, alpha 1
    Hs.496646  [show with all ESTs]
    Unigene Representative Sequence: Y10659
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371666(uc004eqs.3) ENST00000371642(uc004eqr.1) ENST00000481868
    ENST00000371637
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat IL13RA1
      QuantiFast Probe-based Assays in human, mouse, rat IL13RA1

    Additional mRNA sequence: 

    AB209849.1 AK123515.1 AK296958.1 AK313467.1 BC009960.2 BC015768.1 U81379.3 U81380.2 
    Y09328.1 Y10659.1 

    13 DOTS entries:

    DT.91712774  DT.455751  DT.86839825  DT.75102215  DT.91847097  DT.95294102  DT.91741367  DT.95087974 
    DT.100034758  DT.100818994  DT.312623  DT.95216823  DT.91814556 

    Selected AceView cDNA sequences (see all 338):

    AI346619 AI359423 AI436787 AA668629 BQ447053 AA478704 AI523044 BC009960 
    AI859926 AL043521 BQ947261 BU619294 BF447388 AW889256 CB119533 AU185090 
    AI367605 CA391344 AA411324 BU522107 CA312526 AI419528 AI283740 BF724859 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for IL13RA1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                            -           -                       -                           
    SP2:                                                        -                                                   
    SP3:                                            -                                                               
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for IL13RA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL13RA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTCTGGGA
    IL13RA1 Expression
    About this image


    IL13RA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Monocytes Peripheral Blood
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    IL13RA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL13RA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.496646

    UniProtKB/Swiss-Prot: I13R1_HUMAN, P78552
    Tissue specificity: Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain,
    lung and kidney. Also found in B-cells, T-cells and endothelial cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL13RA1: 
              Interferons & Receptors in human mouse rat
              Th1/Th2 Response in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL13RA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL13RA1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il13ra11 , 5 interleukin 13 receptor, alpha 11, 5 81.95(n)1
    75.18(a)1
      X (20.49 cM)5
    161641  NM_133990.41  NP_598751.31 
     361121105 
    chicken
    (Gallus gallus)
    Aves IL13RA11 interleukin 13 receptor, alpha 1 51.35(n)
    38.65(a)
      422230  XM_420218.3  XP_420218.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia il13ra11 interleukin 13 receptor, alpha 1 46.61(n)
    34.11(a)
      101732462  XM_004916929.1  XP_004916986.1 


    ENSEMBL Gene Tree for IL13RA1 (if available)
    TreeFam Gene Tree for IL13RA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IL13RA1 gene
    IL13RA22  IL5RA2  

    Find genes that share paralogs with IL13RA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL13RA1 (see all 1006)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1883750011,2
    C--117855009(+) TATTTA/TTTTTT 1 -- us2k10--------
    rs1114153931,2
    C,F--117855025(+) GAGAAT/CGGGGT 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1121768911,2
    C,F--117855271(+) AATTCT/CTTGTT 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs24956371,2
    C,F,O,A,H--117855338(+) TTTTGA/GTGAGT 1 -- us2k124Minor allele frequency- N:0.00EA NA NS CSA 2552
    rs19372711,2
    C,F,A,H--117855386(+) ATTGAA/GTTTGA 1 -- us2k113Minor allele frequency- G:0.05NS EA WA NA CSA 434
    rs1849526451,2
    --117855512(+) AACTGC/TTTTCA 1 -- us2k10--------
    rs1388011501,2
    --117855699(+) AGTTAC/TGATTA 1 -- us2k10--------
    rs1909753871,2
    --117855946(+) CACACC/TTTGAT 1 -- us2k10--------
    rs1809740801,2
    --117856081(+) CCAGCC/TTCACT 1 -- us2k10--------
    rs1419930271,2
    --117856172(+) TCGTGC/TGCTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL13RA1 (117861535 - 117928502 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IL13RA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1709061CNV Insertion17803354
    dgv527n21CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): IL13RA1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL13RA1
    DNA2.0 Custom Variant and Variant Library Synthesis for IL13RA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300119    OMIM disorders: --

    2 diseases for IL13RA1:    
    About MalaCards
    malignant glioma    atopy


    Find genes that share disorders with IL13RA1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL13RA1 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma allergic 63.6 3 17006604 (3)
    glioblastoma multiforme 56.7 2 12939468 (1), 17398005 (1)
    malignant glioma 54.5 3 10728667 (1), 12481422 (1), 15329913 (1)
    glioma 45.2 5 15329913 (1), 15803373 (1), 12939468 (1), 9407626 (1) (see all 5)
    asthma 37.3 9 10699178 (2), 17392323 (2), 17006604 (2), 17287216 (1) (see all 5)
    atopy 36.4 5 10699178 (1), 17392323 (1)
    brain tumors 35.6 3 10728667 (1), 15838375 (1), 11939409 (1)
    pneumonia interstitial 32.7 1 15161635 (1)
    anaplastic astrocytoma 32.1 1 12939468 (1)
    glioblastoma 31.3 1 15803373 (1)

    Genetic Association Database (GAD): IL13RA1
    Human Genome Epidemiology (HuGE) Navigator: IL13RA1 (13 documents)

    Export disorders for IL13RA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL13RA1 gene, integrated from 10 sources (see all 142):
    (articles sorted by number of sources associating them with IL13RA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex. (PubMed id 9013879)1, 2, 3 Miloux B....Ferrara P. (FEBS Lett. 1997)
    2. cDNA cloning and characterization of the human interleukin 13 receptor alpha chain. (PubMed id 8910586)1, 2, 3 Aman M.J.... Leonard W.J. (J. Biol. Chem. 1996)
    3. Gene-gene interaction between IL-13 and IL-13Ralpha1 is associated with total IgE in Korean children with atopic asthma. (PubMed id 17006604)1, 4, 9 Kim H.B....Hong S.J. (J. Hum. Genet. 2006)
    4. Genetic association studies of interleukin-13 receptor alpha1 subunit gene polymorphisms in asthma and atopy. (PubMed id 17392323)1, 4, 9 Konstantinidis A.K....Holloway J.W. (Eur. Respir. J. 2007)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    7. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    8. Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. (PubMed id 18243101)1, 2 LaPorte S.L.... Garcia K.C. (Cell 2008)
    9. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3597 HGNC: 5974 AceView: IL13RA1 Ensembl:ENSG00000131724 euGenes: HUgn3597
    ECgene: IL13RA1 Kegg: 3597 H-InvDB: IL13RA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IL13RA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IL13RA1 gene:
    Search GeneIP for patents involving IL13RA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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