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IL13 Gene

protein-coding   GIFtS: 67
GCID: GC05P131991

Interleukin 13

  See IL13-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Interleukin 131 2     interleukin-132
IL-132 3     NC303
Allergic Rhinitis1     ALRH5
Bronchial Hyperresponsiveness-1 (Bronchial Asthma)1     BHR15
P6002     

External Ids:    HGNC: 59731   Entrez Gene: 35962   Ensembl: ENSG000001691947   OMIM: 1476835   UniProtKB: P352253   
ORGUL members:         

Export aliases for IL13 gene to outside databases

Previous GC identifers: GC05P131516 GC05P132441 GC05P132023 GC05P132070 GC05P132021 GC05P127186


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL13 Gene:
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is
involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II
expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity,
thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be
critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and
eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene
particularly close to IL4. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL13 Gene:
IL13 (interleukin 13) is a protein-coding gene. Diseases associated with IL13 include asthma, and rhinitis. GO annotations related to this gene include interleukin-13 receptor binding and cytokine activity.

UniProtKB/Swiss-Prot: IL13_HUMAN, P35225
Function: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma
synthesis. May be critical in regulating inflammatory and immune responses

summary for IL13 Gene:
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They
control many different cellular functions including proliferation, differentiation and cell
survival/apoptosis but are also involved in several pathophysiological processes including viral infections
and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the
innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can
be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma,
IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.
Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells.

Gene Wiki entry for IL13 (Interleukin 13) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL13 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL13 promoter sequence
   Search Chromatin IP Primers for IL13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31

IL13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL13 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P131991:  view genomic region     (about GC identifiers)

Start:
131,991,955 bp from pter      End:
131,996,802 bp from pter
Size:
4,848 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IL13_HUMAN, P35225 (See protein sequence)
Recommended Name: Interleukin-13 precursor  
Size: 146 amino acids; 15816 Da
Subunit: Interacts with IL13RA2
Caution: It is uncertain whether Met-1 or Met-15 is the initiator
Sequence caution: Sequence=AAA36107.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAA83738.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAB01681.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAC03535.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAK53823.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=CAA48824.1; Type=Erroneous initiation; Note=Translation
N-terminally extended;
Selected PDB 3D structures from and Proteopedia for IL13 (see all 13):
1GA3 (3D)        1IJZ (3D)        1IK0 (3D)        1J9U (3D)        3BPO (3D)        3G6D (3D)    
Secondary accessions: O43644 Q4VB52 Q9UDC7

Explore the universe of human proteins at neXtProt for IL13: NX_P35225

Explore proteomics data for IL13 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn52, Asn63, Asn71, Asn86

  • See IL13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002179.2  
    ENSEMBL proteins: 
     ENSP00000304915  

    IL13 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant IL13 Protein
    R&D Systems Recombinant & Natural Proteins for IL13 (IL-13)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IL13
    OriGene Protein Over-expression Lysate for IL13
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IL13
    GenScript Purified and Recombinant Proteins for IL13
    Novus Biologicals IL13 Proteins
    Novus Biologicals IL13 Lysate
    Sino Biological Recombinant Protein for IL13
    Sino Biological Cell Lysate for IL13
    ProSpec Recombinant Protein for IL13
    Cloud-Clone Corp. Proteins for IL13

     
    eBioscience Proteins for IL13: (see all 4
                        Recombinant Human IL-13 10 ug

     
    antibodies-online proteins for IL13 (112 products) 

     
    antibodies-online peptides for IL13

    IL13 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL13
    R&D Systems Antibodies for IL13 (IL-13)
    OriGene Antibodies for IL13
    OriGene Custom Antibody Services for IL13
    Novus Biologicals IL13 Antibodies
    Abcam antibodies for IL13
    Cloud-Clone Corp. Antibodies for IL13
    ThermoFisher Antibody for IL13
    antibodies-online antibodies for IL13 (194 products) 

    IL13 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL13
    R&D Systems ELISAs for IL13 (IL-13)         (see first)
    R&D Systems ELISpot/FluoroSpot Kits & Development Modules for IL13 (IL-13)
    R&D Systems Luminex Assays for IL13 (IL-13)
    R&D Systems Proteome Profiler Antibody Arrays for IL13 (IL-13)
    See all other biochemical assays at R&D Systems
    GenScript Custom Assay Services for IL13
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL13
    Cloud-Clone Corp. CLIAs for IL13
    eBioscience ELISAs for IL13: (see all 6
                        Human IL-13 ELISPOT Ready-SET-Go! 2 x 96 tests
    antibodies-online kits for IL13 (102 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    5 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR020470 IL-13
     IPR009079 4_helix_cytokine-like_core
     IPR001325 IL-4/IL-13
     IPR018096 IL-4/IL-13_CS

    Graphical View of Domain Structure for InterPro Entry P35225

    ProtoNet protein and cluster: P35225

    1 Blocks protein domain: IPB001325 Interleukin-4/interleukin-13

    UniProtKB/Swiss-Prot: IL13_HUMAN, P35225
    Similarity: Belongs to the IL-4/IL-13 family


    Find genes that share domains with IL13           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL13_HUMAN, P35225
    Function: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma
    synthesis. May be critical in regulating inflammatory and immune responses

         Genatlas biochemistry entry for IL13:
    interleukin 13,expressed in activated T cell,important switch factor directing Ig-E synthesis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005126cytokine receptor binding ----
    GO:0005144interleukin-13 receptor binding IEA--
    GO:0005515protein binding IPI18243101
         
    Find genes that share ontologies with IL13           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for IL13:
     Increased cell death HMECs cel  Increased gamma-H2AX phosphory 

         13 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Il13):
     cellular  digestive/alimentary  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
     no phenotypic analysis  reproductive system  respiratory system 

    Find genes that share phenotypes with IL13           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IL13: Il4/Il13Il4/tm3Anjm Il13tm2Anjm

       genOway: Develop your customized and physiologically relevant rodent model for IL13

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL13:
    hsa-let-7f-5p (MIRT006400), hsa-let-7d-5p (MIRT006398), hsa-mir-98-5p (MIRT006397), hsa-let-7i-5p (MIRT006401), hsa-let-7g-5p (MIRT006399)

    Block miRNA regulation of human, mouse, rat IL13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL13 (see all 16):
    hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-512-3p hsa-let-7g hsa-let-7a hsa-miR-155 hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidIL13 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL13
    Predesigned siRNA for gene silencing in human, mouse, rat IL13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL13

    Clone
    Products:
         
    OriGene clones in human, mouse for IL13 (see all 5)
    OriGene ORF clones in mouse, rat for IL13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL13 (NM_002188)
    Sino Biological Human cDNA Clone for IL13
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL13
    Addgene plasmids for IL13 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL13
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL13 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL13

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VF6-14271) for IL13 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL13_HUMAN, P35225: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    plasma membrane2
    cytoskeleton1
    cytosol1
    lysosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA--
    GO:0005615extracellular space ISS16275384
    GO:0005737cytoplasm IEA--
    GO:0009897external side of plasma membrane IEA--

    Find genes that share ontologies with IL13           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL13 About   (see all 20)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    MAPK Family Pathway0.60
    SOCS Pathway0.40
    JAK-STAT Pathway0.57
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    5PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56


    Find genes that share SuperPaths with IL13           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for IL13
        IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL13 (see all 26)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Tec Kinases Signaling

    3 Tocris Bioscience Pathways for IL13
        Akt Pathway
    Toll-like Receptor Pathway
    MAPK Pathway

    4 BioSystems Pathways for IL13
        Cytokines and Inflammatory Response
    SIDS Susceptibility Pathways
    IL12 signaling mediated by STAT4
    Glucocorticoid receptor regulatory network



    Selected Kegg Pathways  (Kegg details for IL13) (see all 6):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    Fc epsilon RI signaling pathway
    Measles
    Asthma

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL13 (see all 15): 
              Fibrosis in human mouse rat
              Multiple Sclerosis in human mouse rat
              Interferons & Receptors in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL13 (P352251, 3 ENSP000003049154) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL13RA1P785521, 3, ENSP000003607304EBI-1647828,EBI-1391535 I2D: score=3 STRING: ENSP00000360730
    IL13RA2Q146273, ENSP000002432134I2D: score=2 STRING: ENSP00000243213
    PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
    IL4RP243943, ENSP000001706304I2D: score=1 STRING: ENSP00000170630
    VCAM1P193203, ENSP000002947284I2D: score=1 STRING: ENSP00000294728
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002639positive regulation of immunoglobulin production IEA--
    GO:0006928cellular component movement TAS10725748
    GO:0006954inflammatory response TAS8096327
    GO:0006955immune response IEA--
    GO:0007165signal transduction NAS10725748

    Find genes that share ontologies with IL13           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for IL13 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
    PirfenidoneAntifibrotic agent; regulates cytokine levels in vivo[53179-13-8]
    GIT 27Immunomodulator; reduces production of pro-inflammatory cytokines[6501-72-0]
    4-IPPInhibitor of macrophage migration inhibitory factor (MIF); suicide substrate[41270-96-6]
    ThalidomideTNF-alpha synthesis inhibitor[50-35-1]

    Selected Novoseek inferred chemical compound relationships for IL13 gene (see all 124)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 78.4 104 9644628 (5), 10069878 (4), 8879177 (3), 11385231 (3) (see all 81)
    tarc 74.8 49 12871855 (6), 12441140 (3), 12445798 (3), 16387595 (3) (see all 21)
    allergens 72.6 50 19220774 (4), 15969674 (3), 16433854 (2), 12562325 (2) (see all 41)
    scca1 65.9 6 12421571 (1), 14630915 (1), 16238792 (1), 12940509 (1) (see all 5)
    il 10 65.1 25 9130625 (2), 17928005 (2), 12944981 (1), 19064561 (1) (see all 22)
    mip 1alpha 62.7 2 17823085 (1), 17027994 (1)
    histamine 59.9 89 16918506 (4), 10224376 (4), 16940746 (4), 9469459 (3) (see all 51)
    alpha-galactosylceramide 57.2 12 12433369 (1), 17015708 (1), 18350544 (1), 16027139 (1) (see all 7)
    omalizumab 51.6 5 19844128 (1), 16751018 (1), 17368811 (1)
    ionomycin 50.3 36 11959794 (4), 9158101 (3), 9856820 (2), 7629513 (1) (see all 22)



    Find genes that share compounds with IL13           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL13 gene: 
    NM_002188.2  

    Unigene Cluster for IL13:

    Interleukin 13
    Hs.845  [show with all ESTs]
    Unigene Representative Sequence: BC096138
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000468334 ENST00000459878 ENST00000487267 ENST00000462480 ENST00000304506(uc003kxj.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IL13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL13 (see all 16):
    hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-512-3p hsa-let-7g hsa-let-7a hsa-miR-155 hsa-miR-98
    SwitchGear 3'UTR luciferase reporter plasmidIL13 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IL13
    Predesigned siRNA for gene silencing in human, mouse, rat IL13
    Clone
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    OriGene clones in human, mouse for IL13 (see all 5)
    OriGene ORF clones in mouse, rat for IL13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL13 (NM_002188)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL13
    Addgene plasmids for IL13 
    Primer
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    OriGene qPCR primer pairs and template standards for IL13
    OriGene qSTAR qPCR primer pairs in human, mouse for IL13
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL13
      QuantiTect SYBR Green Assays in human, mouse, rat IL13
      QuantiFast Probe-based Assays in human, mouse, rat IL13
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VF6-14271) for IL13 

    Additional mRNA sequence: 

    AF043334.1 BC096138.3 BC096139.1 BC096140.3 BC096141.1 L06801.1 X69079.1 

    4 DOTS entries:

    DT.308922  DT.120864373  DT.120864368  DT.97833631 

    13 AceView cDNA sequences:

    NM_002188 BM554360 BV198268 BM564270 AF043334 X69079 BM908160 BX107098 
    BG716949 L06801 AI208823 AA905851 BG717338 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IL13    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                          -                                             
    SP2:                    -     -                                             
    SP3:                          -     -                                       
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for IL13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTGGGACA
    IL13 Expression
    About this image


    IL13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Villous Cytotrophoblast Cells Chorionic Villus
     
     NULL (Uncategorized)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
    IL13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.845
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL13 (see all 15): 
              Fibrosis in human mouse rat
              Multiple Sclerosis in human mouse rat
              Interferons & Receptors in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for IL13 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il131 , 5 interleukin 131, 5 71.04(n)1
    62.3(a)1
      11 (31.98 cM)5
    161631  NM_008355.31  NP_032381.11 
     536313245 


    ENSEMBL Gene Tree for IL13 (if available)
    TreeFam Gene Tree for IL13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL13 (see all 210)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1386804961,2
    Cuntested1132271957(+) ACAGGC/TTCCGC 2 A V mis10--------
    rs205411,2,,4
    C,F,A,Hother1132272810(-) TGAACC/TGTCCC 2 Q R mis155Minor allele frequency- N:0.00MN NS EA NA WA CSA EU 10688
    rs1150080991,2
    C,F--132268727(+) TGGAGC/TGGCAC 1 -- us2k12Minor allele frequency- T:0.19NA EA 240
    rs1867884191,2
    --132268845(+) GGACCA/GCCACC 1 -- us2k10--------
    rs18814571,2
    C,F,A,H--132269255(+) CGTAGA/CGGGGT 1 -- us2k122Minor allele frequency- C:0.21NS EA MN WA CSA 2641
    rs20697381,2
    C,F--132269261(+) GGGGTCA/-CACGG 1 -- us2k12Minor allele frequency- -:0.10NS 88
    rs356417051,2
    F--132269263(+) GGTCA-/CACGGCCA 1 -- us2k15Minor allele frequency- CAC:0.05MN 404
    rs20697391,2
    C,F--132269454(+) TTGTGA/GGGAGG 1 -- us2k112Minor allele frequency- G:0.16NS EA WA 1042
    rs1823490151,2
    --132269494(+) AGCCCC/TATCGA 1 -- us2k10--------
    rs20697401,2
    C,F--132269624(+) TCTGCT/AGTGGG 1 -- us2k111Minor allele frequency- A:0.01NS NA MN EA WA 772

    HapMap Linkage Disequilibrium report for IL13 (131991955 - 131996802 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IL13:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6332n71CNV Gain21882294
    nsv528281CNV Gain19592680

    Human Gene Mutation Database (HGMD): IL13
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL13
    DNA2.0 Custom Variant and Variant Library Synthesis for IL13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147683   
    OMIM disorders: 600807  607154  
    UniProtKB/Swiss-Prot: IL13_HUMAN, P35225
  • Allergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal
    inflammation caused by allergen exposure. Note=Disease susceptibility is associated with variations affecting the
    gene represented in this entry

  • Selected diseases for IL13 (see all 36):    
    About MalaCards
    asthma    rhinitis    allergic rhinitis    allergic asthma
    brain cancer    angiostrongyliasis    actinic prurigo    lipoid nephrosis
    schistosomiasis    helminthiasis    african tick-bite fever    eosinophilic meningitis
    pneumonia    vasomotor rhinitis    idiopathic interstitial pneumonia    esophagitis
    keratoconjunctivitis    filariasis    classic kaposi sarcoma    leishmaniasis

    5 diseases from the University of Copenhagen DISEASES database for IL13:
    Asthma     Eosinophilia     Hypersensitivity reaction type I disease     Malignant glioma
    Atopic dermatitis

    Find genes that share disorders with IL13           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IL13 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma allergic 84.1 102 17006604 (4), 11197307 (4), 11737051 (3), 20477017 (3) (see all 65)
    asthma 83.9 531 18328894 (8), 15536417 (7), 9155833 (7), 10699178 (6) (see all 99)
    inflammation 78 228 17142763 (3), 12704343 (3), 19635933 (3), 18258919 (3) (see all 99)
    dermatitis atopic 77.9 69 15014952 (6), 9199876 (3), 9669111 (2), 11168792 (2) (see all 45)
    atopy 75.8 63 8980464 (3), 16024972 (3), 10699178 (2), 11588017 (2) (see all 48)
    allergy 74.6 75 18849614 (4), 20418295 (3), 12432502 (2), 15711639 (2) (see all 52)
    eosinophilia 72.1 42 12007717 (2), 10069878 (1), 11292021 (1), 15032597 (1) (see all 38)
    necrosis 71.9 310 8921290 (2), 9176402 (2), 10211885 (2), 10030846 (2) (see all 99)
    airways disease 64.4 11 19299500 (3), 19875687 (1), 12624114 (1), 19878194 (1) (see all 8)
    allergic rhinitis 62.7 18 17088137 (4), 17091279 (3), 9224205 (2), 9862737 (1) (see all 9)

    Genetic Association Database (GAD): IL13
    Human Genome Epidemiology (HuGE) Navigator: IL13 (221 documents)

    Export disorders for IL13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL13 gene, integrated from 10 sources (see all 2293):
    (articles sorted by number of sources associating them with IL13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis. (PubMed id 12928861)1, 2, 4, 9 Wang M....Yu L.-S. (Hum. Genet. 2003)
    2. Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population. (PubMed id 11588017)1, 2, 4, 9 Howard T.D.... Bleecker E.R. (Am. J. Respir. Cell Mol. Biol. 2001)
    3. Genetic variants of IL-13 signalling and human asthma and atopy. (PubMed id 10699178)1, 2, 4, 9 Heinzmann A.... Deichmann K.A. (Hum. Mol. Genet. 2000)
    4. Patterns of GATA3 and IL13 gene polymorphisms associated with childhood rhinitis and atopy in a birth cohort. (PubMed id 18037162)1, 4, 9 Huebner M....Arshad S.H. (J. Allergy Clin. Immunol. 2008)
    5. Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma. (PubMed id 17303794)1, 4, 9 Battle N.C....Burchard E.G. (Am. J. Respir. Crit. Care Med. 2007)
    6. Association between the polymorphisms of IL-4 gene promoter (-590C&gt;T), IL-13 coding region (R130Q) and IL-16 gene promoter (-295T&gt;C) and allergic asthma. (PubMed id 17303923)1, 4, 9 Hosseini-Farahabadi S....Khaje Daluei M. (Iran J Allergy Asthma Immunol 2007)
    7. Gene-gene interaction between IL-13 and IL-13Ralpha1 is associated with total IgE in Korean children with atopic asthma. (PubMed id 17006604)1, 4, 9 Kim H.B....Hong S.J. (J. Hum. Genet. 2006)
    8. Tandem arrangement of human genes for interleukin-4 and interleukin- 13: resemblance in their organization. (PubMed id 7721105)1, 2, 9 Smirnov D.V.... Frolova E.I. (Gene 1995)
    9. Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31. (PubMed id 8605348)1, 2, 9 Dolganov G.... Lewis D.B. (Blood 1996)
    10. Relationships between specific serum IgE, cytokines and polymorphisms in the IL-4, IL-4Ralpha in patients with penicillins allergy. (PubMed id 15969687)1, 4, 9 Qiao H.L....Zhang Y.W. (Allergy 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3596 HGNC: 5973 AceView: IL13 Ensembl:ENSG00000169194 euGenes: HUgn3596
    ECgene: IL13 Kegg: 3596 H-InvDB: IL13

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL13 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_13
    SeattleSNPshttp://pga.gs.washington.edu/data/il13/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL13 gene:
    Search GeneIP for patents involving IL13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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