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Aliases for IL13 Gene

Aliases for IL13 Gene

  • Interleukin 13 2 3 5
  • IL-13 3 4
  • Bronchial Hyperresponsiveness-1 (Bronchial Asthma) 2
  • Allergic Rhinitis 2
  • Interleukin-13 3
  • P600 3
  • NC30 4

External Ids for IL13 Gene

Previous GeneCards Identifiers for IL13 Gene

  • GC05P131516
  • GC05P132441
  • GC05P132023
  • GC05P132070
  • GC05P132021
  • GC05P131991
  • GC05P127186

Summaries for IL13 Gene

Entrez Gene Summary for IL13 Gene

  • This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL13 Gene

IL13 (Interleukin 13) is a Protein Coding gene. Diseases associated with IL13 include Asthma and Allergic Rhinitis. Among its related pathways are PEDF Induced Signaling and Th2 Differentiation Pathway. GO annotations related to this gene include cytokine activity and interleukin-13 receptor binding.

UniProtKB/Swiss-Prot for IL13 Gene

  • Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).

Tocris Summary for IL13 Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Gene Wiki entry for IL13 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL13 Gene

Genomics for IL13 Gene

Regulatory Elements for IL13 Gene

Enhancers for IL13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G132770 1.6 Ensembl ENCODE dbSUPER 10.7 +118.2 118240 7.9 HDGF PKNOX1 FOXA2 ARID4B SIN3A ZBTB7B YY1 ZNF766 CBX5 ZNF143 SEPT8 CCNI2 KIF3A SOWAHA SHROOM1 TH2LCRR IL13 IL4 RNU7-15P RNA5SP192
GH05G132812 1.2 ENCODE dbSUPER 10.7 +159.3 159340 5.4 CBX3 BMI1 YY1 GLIS2 EGR2 ZNF263 ZNF202 ZNF362 ZNF280D CEBPB GDF9 RNU7-15P RNA5SP192 CCNI2 UQCRQ KIF3A TH2LCRR IL13 IL4 ENSG00000230612
GH05G132806 1.2 ENCODE dbSUPER 9.8 +151.1 151138 2.0 ATF1 FOXA2 ZNF133 WRNIP1 ARID4B DMAP1 YBX1 ZNF48 YY1 ZNF143 GDF9 TH2LCRR RNU7-15P RNA5SP192 IL13 SEPT8 SOWAHA
GH05G132736 1 ENCODE 11.1 +81.5 81516 2.6 HDGF PKNOX1 FOXA2 AGO1 ARID4B SIN3A DMAP1 BRCA1 ZNF2 ZNF48 SEPT8 ENSG00000230612 IL4 TH2LCRR IL13 SHROOM1 RAD50 IL5 RNU7-15P RNA5SP192
GH05G132529 1 FANTOM5 ENCODE 10.1 -126.8 -126801 0.2 HDAC1 ATF1 TAL1 TCF12 ZNF316 MAFK SMARCE1 DPF2 ZEB2 ARID1B IL5 RAD50 SOWAHA IL4 ENSG00000230612 IL13 CSF2 IL3 SLC22A5 GC05P132531
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL13 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the IL13 gene promoter:

Genomic Location for IL13 Gene

Chromosome:
5
Start:
132,656,263 bp from pter
End:
132,661,110 bp from pter
Size:
4,848 bases
Orientation:
Plus strand

Genomic View for IL13 Gene

Genes around IL13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL13 Gene

Proteins for IL13 Gene

  • Protein details for IL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35225-IL13_HUMAN
    Recommended name:
    Interleukin-13
    Protein Accession:
    P35225
    Secondary Accessions:
    • O43644
    • Q4VB52
    • Q9UDC7

    Protein attributes for IL13 Gene

    Size:
    146 amino acids
    Molecular mass:
    15816 Da
    Quaternary structure:
    • Interacts with IL13RA2.
    SequenceCaution:
    • Sequence=AAA36107.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA83738.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAB01681.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC03535.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK53823.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA48824.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL13 Gene

neXtProt entry for IL13 Gene

Post-translational modifications for IL13 Gene

  • Glycosylation at posLast=5252, isoforms=63, isoforms=71, and posLast=8686

Other Protein References for IL13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for IL13

No data available for DME Specific Peptides for IL13 Gene

Domains & Families for IL13 Gene

Gene Families for IL13 Gene

Graphical View of Domain Structure for InterPro Entry

P35225

UniProtKB/Swiss-Prot:

IL13_HUMAN :
  • Belongs to the IL-4/IL-13 family.
Family:
  • Belongs to the IL-4/IL-13 family.
genes like me logo Genes that share domains with IL13: view

Function for IL13 Gene

Molecular function for IL13 Gene

GENATLAS Biochemistry:
interleukin 13,expressed in activated T cell,important switch factor directing Ig-E synthesis
UniProtKB/Swiss-Prot Function:
Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).

Gene Ontology (GO) - Molecular Function for IL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity TAS,IEA --
GO:0005126 cytokine receptor binding IEA --
GO:0005144 interleukin-13 receptor binding IEA --
GO:0005515 protein binding IPI 18243101
genes like me logo Genes that share ontologies with IL13: view
genes like me logo Genes that share phenotypes with IL13: view

Animal Models for IL13 Gene

MGI Knock Outs for IL13:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IL13

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL13 Gene

Localization for IL13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL13 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 3
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005615 extracellular space ISS 16275384
GO:0005737 cytoplasm IEA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with IL13: view

Pathways & Interactions for IL13 Gene

genes like me logo Genes that share pathways with IL13: view

SIGNOR curated interactions for IL13 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation IEA --
GO:0002639 positive regulation of immunoglobulin production IEA --
GO:0006928 movement of cell or subcellular component TAS 10725748
GO:0006954 inflammatory response IEA,TAS --
GO:0006955 immune response IEA --
genes like me logo Genes that share ontologies with IL13: view

Drugs & Compounds for IL13 Gene

(97) Drugs for IL13 Gene - From: DrugBank, PharmGKB, ClinicalTrials, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Histamine Approved, Investigational Pharma Full agonist, Agonist 1050
Montelukast Approved Pharma Antagonist 270
Omalizumab Approved, Investigational Pharma 145
Sunitinib Approved, Investigational Pharma VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors, Potent VEGFR, PDGFRbeta and KIT inhibitor 510
Coal tar Approved Pharma 202

(49) Additional Compounds for IL13 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-IPP
41270-96-6
AS 2444697
1287665-60-4
ISO 1
478336-92-4

(5) Tocris Compounds for IL13 Gene

Compound Action Cas Number
4-IPP Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate 41270-96-6
AS 2444697 Potent and selective IRAK4 inhibitor 1287665-60-4
ISO 1 Macrophage migration inhibitory factor (MIF) inhibitor 478336-92-4
Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo 53179-13-8
Thalidomide TNF-alpha synthesis inhibitor 50-35-1
genes like me logo Genes that share compounds with IL13: view

Transcripts for IL13 Gene

mRNA/cDNA for IL13 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL13 Gene

Interleukin 13:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IL13

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL13 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: - -
SP3: - -
SP4:
SP5:

Relevant External Links for IL13 Gene

GeneLoc Exon Structure for
IL13
ECgene alternative splicing isoforms for
IL13

Expression for IL13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL13 Gene

This gene is overexpressed in Testis (x46.3).

NURSA nuclear receptor signaling pathways regulating expression of IL13 Gene:

IL13

SOURCE GeneReport for Unigene cluster for IL13 Gene:

Hs.845

Evidence on tissue expression from TISSUES for IL13 Gene

  • Blood(4.7)
  • Lung(3.5)
  • Lymph node(2.9)
  • Spleen(2.9)
  • Intestine(2.7)
  • Skin(2.7)
  • Bone marrow(2.3)
  • Muscle(2.3)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with IL13: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL13 Gene

Orthologs for IL13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL13 34 35
  • 99.24 (n)
cow
(Bos Taurus)
Mammalia IL13 34 35
  • 80.56 (n)
dog
(Canis familiaris)
Mammalia IL13 34 35
  • 79.23 (n)
rat
(Rattus norvegicus)
Mammalia Il13 34
  • 74.32 (n)
mouse
(Mus musculus)
Mammalia Il13 34 16 35
  • 71.04 (n)
Species where no ortholog for IL13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL13 Gene

ENSEMBL:
Gene Tree for IL13 (if available)
TreeFam:
Gene Tree for IL13 (if available)

Paralogs for IL13 Gene

No data available for Paralogs for IL13 Gene

Variants for IL13 Gene

Sequence variations from dbSNP and Humsavar for IL13 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs20541 other 132,660,272(-) TGAAC(C/T)GTCCC reference, missense
rs1000169601 -- 132,659,612(+) CTTCC(C/T)GCCCA intron-variant
rs1000978586 -- 132,660,576(+) TGTAG(C/T)ATTAC utr-variant-3-prime
rs1001232679 -- 132,661,251(+) TGACC(C/T)GGGCT downstream-variant-500B
rs1001579345 -- 132,660,901(+) TCAGG(A/G)GAGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IL13 Gene

Variant ID Type Subtype PubMed ID
nsv528281 CNV gain 19592680
nsv950392 CNV deletion 24416366

Variation tolerance for IL13 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL13 Gene

Human Gene Mutation Database (HGMD)
IL13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL13 Gene

Disorders for IL13 Gene

MalaCards: The human disease database

(82) MalaCards diseases for IL13 Gene - From: OMIM, ClinVar, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, protection against
allergic rhinitis
  • atopic rhinitis
asthma susceptibility, il13-related
  • asthma, susceptibility to
allergic asthma
  • atopic asthma
lipoid nephrosis
  • minimal change disease
- elite association - COSMIC cancer census association via MalaCards
Search IL13 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IL13_HUMAN
  • Allergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for IL13

Genetic Association Database (GAD)
IL13
Human Genome Epidemiology (HuGE) Navigator
IL13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL13
genes like me logo Genes that share disorders with IL13: view

No data available for Genatlas for IL13 Gene

Publications for IL13 Gene

  1. IL13 variants are associated with total serum IgE and early sensitization to food allergens in children with atopic dermatitis. (PMID: 19220774) Zitnik S.E. … Nickel R. (Pediatr Allergy Immunol 2009) 3 22 46 64
  2. Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children. (PMID: 18691306) Chan I.H. … Lam C.W. (Allergy 2008) 3 22 46 64
  3. Association of IL-13 polymorphisms with leukotriene receptor antagonist drug responsiveness in Korean children with exercise-induced bronchoconstriction. (PMID: 18551035) Kang M.J. … Hong S.J. (Pharmacogenet. Genomics 2008) 3 22 46 64
  4. Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population. (PMID: 17355643) Huang H.Y. … Helzlsouer K.J. (BMC Genet. 2007) 3 22 46 64
  5. Impact of genetic variants in IL-4, IL-4 RA and IL-13 on the anti-pneumococcal antibody response. (PMID: 16914241) Wiertsema S.P. … Le SouAf P.N. (Vaccine 2007) 3 22 46 64

Products for IL13 Gene

Sources for IL13 Gene

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