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Aliases for IL12RB2 Gene

Aliases for IL12RB2 Gene

  • Interleukin 12 Receptor, Beta 2 2 3
  • IL-12 Receptor Subunit Beta-2 4
  • IL-12R Subunit Beta-2 4
  • IL-12R-Beta-2 4
  • IL-12RB2 4

External Ids for IL12RB2 Gene

Previous GeneCards Identifiers for IL12RB2 Gene

  • GC01P067733
  • GC01P066704
  • GC01P067130
  • GC01P067142
  • GC01P067485
  • GC01P067545
  • GC01P067773
  • GC01P065882

Summaries for IL12RB2 Gene

Entrez Gene Summary for IL12RB2 Gene

  • The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for IL12RB2 Gene

IL12RB2 (Interleukin 12 Receptor, Beta 2) is a Protein Coding gene. Diseases associated with IL12RB2 include leprosy and behcet's disease. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include protein kinase binding and cytokine receptor activity. An important paralog of this gene is CSF3R.

UniProtKB/Swiss-Prot for IL12RB2 Gene

  • Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production

Gene Wiki entry for IL12RB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL12RB2 Gene

Genomics for IL12RB2 Gene

Regulatory Elements for IL12RB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IL12RB2 Gene

Start:
67,307,364 bp from pter
End:
67,396,900 bp from pter
Size:
89,537 bases
Orientation:
Plus strand

Genomic View for IL12RB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL12RB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL12RB2 Gene

Proteins for IL12RB2 Gene

  • Protein details for IL12RB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99665-I12R2_HUMAN
    Recommended name:
    Interleukin-12 receptor subunit beta-2
    Protein Accession:
    Q99665
    Secondary Accessions:
    • B1AN98
    • B7ZKL9
    • F5H7L6
    • Q2M3V3

    Protein attributes for IL12RB2 Gene

    Size:
    862 amino acids
    Molecular mass:
    97135 Da
    Quaternary structure:
    • Heterodimer/heterooligomer; disulfide-linked. The functional high affinity IL12 receptor is composed of I12RB1 and IL12RB2. Il12RB2 binds JAK2 (via its N-terminal) through a membrane-proximal region of the cytoplasmic domain. Interaction, in vitro and in vivo, with SOCS3 (via its SH2 domain) inhibits the STAT4-mediated activation. Binds STAT4 through a membrane-distal C-terminal region

    Alternative splice isoforms for IL12RB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL12RB2 Gene

Proteomics data for IL12RB2 Gene at MOPED

Post-translational modifications for IL12RB2 Gene

  • On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.
  • Glycosylation at Asn48, Asn129, Asn166, Asn195, Asn271, Asn347, Asn376, and Asn480
  • Modification sites at PhosphoSitePlus

Other Protein References for IL12RB2 Gene

Antibody Products

  • R&D Systems Antibodies for IL12RB2 (IL-12 R beta 2)

No data available for DME Specific Peptides for IL12RB2 Gene

Domains for IL12RB2 Gene

Gene Families for IL12RB2 Gene

HGNC:
  • FN3 :Fibronectin type III domain containing
  • IL :Interleukins and interleukin receptors
IUPHAR :

Suggested Antigen Peptide Sequences for IL12RB2 Gene

Graphical View of Domain Structure for InterPro Entry

Q99665

UniProtKB/Swiss-Prot:

I12R2_HUMAN :
  • Q99665
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding
  • The box 1 motif is required for JAK interaction and/or activation
  • Contains 5 fibronectin type-III domains.
Family:
  • Belongs to the type I cytokine receptor family. Type 2 subfamily.
genes like me logo Genes that share domains with IL12RB2: view

Function for IL12RB2 Gene

Molecular function for IL12RB2 Gene

GENATLAS Biochemistry:
interleukin 12 receptor,subunit B2,low affinity,132kDa,heterodimerizing with IL12RB1,expressed on Th1 cells
UniProtKB/Swiss-Prot Function:
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production
UniProtKB/Swiss-Prot Induction:
In vitro, up-regulated by IFN-alpha.

Gene Ontology (GO) - Molecular Function for IL12RB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity TAS 8943050
GO:0005515 protein binding --
GO:0019901 protein kinase binding --
genes like me logo Genes that share ontologies with IL12RB2: view
genes like me logo Genes that share phenotypes with IL12RB2: view

Animal Models for IL12RB2 Gene

MGI Knock Outs for IL12RB2:

Animal Model Products

miRNA for IL12RB2 Gene

miRTarBase miRNAs that target IL12RB2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL12RB2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL12RB2 Gene

Localization for IL12RB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL12RB2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL12RB2 Gene COMPARTMENTS Subcellular localization image for IL12RB2 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL12RB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8943050
GO:0009897 external side of plasma membrane --
genes like me logo Genes that share ontologies with IL12RB2: view

Pathways for IL12RB2 Gene

genes like me logo Genes that share pathways with IL12RB2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for IL12RB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS 8943050
GO:0008284 positive regulation of cell proliferation TAS 8943050
GO:0018108 peptidyl-tyrosine phosphorylation --
GO:0019221 cytokine-mediated signaling pathway TAS 8943050
GO:0032496 response to lipopolysaccharide --
genes like me logo Genes that share ontologies with IL12RB2: view

Compounds for IL12RB2 Gene

(1) Novoseek inferred chemical compound relationships for IL12RB2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 7.44 2
genes like me logo Genes that share compounds with IL12RB2: view

Transcripts for IL12RB2 Gene

Unigene Clusters for IL12RB2 Gene

Interleukin 12 receptor, beta 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL12RB2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL12RB2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: - - -
SP2:
SP3: - -
SP4:
SP5:
SP6:

Relevant External Links for IL12RB2 Gene

GeneLoc Exon Structure for
IL12RB2
ECgene alternative splicing isoforms for
IL12RB2

Expression for IL12RB2 Gene

mRNA expression in normal human tissues for IL12RB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL12RB2 Gene

This gene is overexpressed in Muscle - Skeletal (6.2) and Whole Blood (4.2).

Protein differential expression in normal tissues for IL12RB2 Gene

This gene is overexpressed in Pancreas (48.6), Placenta (6.2), and Bone marrow mesenchymal stem cell (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL12RB2 Gene

SOURCE GeneReport for Unigene cluster for IL12RB2 Gene Hs.479347

mRNA Expression by UniProt/SwissProt for IL12RB2 Gene

Q99665-I12R2_HUMAN
Tissue specificity: Isoform 2 is expressed at similar levels in both naive and activated T-cells.
genes like me logo Genes that share expressions with IL12RB2: view

Expression partners for IL12RB2 Gene

In Situ Assay Products

Orthologs for IL12RB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL12RB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL12RB2 35
  • 85.29 (n)
  • 79.21 (a)
IL12RB2 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL12RB2 35
  • 85.08 (n)
  • 77.16 (a)
IL12RB2 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il12rb2 35
  • 76.7 (n)
  • 67.68 (a)
Il12rb2 16
Il12rb2 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL12RB2 35
  • 99.27 (n)
  • 99.3 (a)
IL12RB2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il12rb2 35
  • 76.68 (n)
  • 66.67 (a)
oppossum
(Monodelphis domestica)
Mammalia IL12RB2 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL12RB2 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL12RB2 35
  • 53.8 (n)
  • 38.59 (a)
IL12RB2 36
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 21 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia il12rb2 35
  • 49.09 (n)
  • 33.48 (a)
zebrafish
(Danio rerio)
Actinopterygii il12rb2 35
  • 45.34 (n)
  • 33.57 (a)
il12rb2 36
  • 23 (a)
OneToMany
IL12RB2 (2 of 2) 36
  • 24 (a)
OneToMany
Species with no ortholog for IL12RB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL12RB2 Gene

ENSEMBL:
Gene Tree for IL12RB2 (if available)
TreeFam:
Gene Tree for IL12RB2 (if available)

Paralogs for IL12RB2 Gene

Paralogs for IL12RB2 Gene

genes like me logo Genes that share paralogs with IL12RB2: view

Variants for IL12RB2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IL12RB2 Gene

Q99665-I12R2_HUMAN
Heterozygotic variants Gly-313 and Arg-720 are associated with atopy, an immunological condition that can lead to clinical symptoms such as allergic rhinitis, sinusitis, asthma and eczema

Sequence variations from dbSNP and Humsavar for IL12RB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs729188 -- 67,337,249(-) TAGAA(A/G)GTTCC intron-variant
rs746389 -- 67,337,120(-) TGTGT(A/G)GGCCC intron-variant
rs755826 -- 67,312,594(-) TCTTT(A/G)TTTCC intron-variant
rs873653 -- 67,312,709(-) caatg(G/T)gtttt intron-variant
rs881086 -- 67,380,429(+) taggc(A/T)aggat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL12RB2 Gene

Variant ID Type Subtype PubMed ID
nsv482980 CNV Loss 15286789
nsv870652 CNV Loss 21882294
nsv871374 CNV Loss 21882294
nsv10228 CNV Gain 18304495
nsv871075 CNV Gain 21882294
nsv871879 CNV Loss 21882294
nsv461773 CNV Loss 19166990
esv2661290 CNV Deletion 23128226
dgv236n71 CNV Loss 21882294
nsv1254 CNV Insertion 18451855

Relevant External Links for IL12RB2 Gene

HapMap Linkage Disequilibrium report
IL12RB2
Human Gene Mutation Database (HGMD)
IL12RB2

Disorders for IL12RB2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for IL12RB2 Gene in MalaCards »

(2) Diseases for IL12RB2 Gene including...

(12) Novoseek inferred disease relationships for IL12RB2 Gene

Disease -log(P) Hits PubMed IDs
asthma allergic 33.5 3
burkitt lymphoma 23.2 1
sarcoidosis 22.2 1
atopy 16.8 1
autoimmunity 14.6 2

Relevant External Links for IL12RB2

Genetic Association Database (GAD)
IL12RB2
Human Genome Epidemiology (HuGE) Navigator
IL12RB2
genes like me logo Genes that share disorders with IL12RB2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for IL12RB2 Gene

Publications for IL12RB2 Gene

  1. Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane- proximal region of interleukin-12 receptor beta 2 via amino- terminus. (PMID: 10198225) Yamamoto K. … Miyasaka N. (Biochem. Biophys. Res. Commun. 1999) 3 4 23
  2. Assignment of IL12RB1 and IL12RB2, interleukin-12 receptor beta 1 and beta 2 chains, to human chromosome 19 band p13.1 and chromosome 1 band p31.2, respectively, by in situ hybridization. (PMID: 9284929) Yamamoto K. … Miyasaka N. (Cytogenet. Cell Genet. 1997) 2 3 23
  3. Association study between interleukin-12 receptor beta1/beta2 genes and type 1 diabetes or asthma in the Japanese population. (PMID: 12719941) Bassuny W.M. … Hara T. (Immunogenetics 2003) 3 23 48
  4. Missense mutations of the interleukin-12 receptor beta 1(IL12RB1) and interferon-gamma receptor 1 (IFNGR1) genes are not associated with susceptibility to lepromatous leprosy in Korea. (PMID: 12743658) Lee S.B. … Chae G.T. (Immunogenetics 2003) 3 23 48
  5. A novel polymorphic GATA site in the human IL-12Rbeta2 promoter region affects transcriptional activity. (PMID: 15140029) van Rietschoten J.G. … Wierenga E.A. (Tissue Antigens 2004) 3 23 48

Products for IL12RB2 Gene

Sources for IL12RB2 Gene

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