IL12RB1 Gene
protein-coding GIFtS: 62
GCID: GC19M018170
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interleukin 12 receptor, beta 1
(Previous symbol: IL12RB)
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Aliases
for IL12RB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interleukin 12 Receptor, Beta 11 2 | | Interleukin-12 Receptor Beta-1 Chain2 | | IL12RB1 2 3 | | Interleukin-12 Receptor Subunit Beta-12 | | CD2121 2 | | IL-12R-Beta-11 | | IL-12 Receptor Beta Component2 3 | | IL-12RB13 | | IL-12 Receptor Subunit Beta-12 3 | | IL12R3 | | IL-12R Subunit Beta-12 3 | | CD212 Antigen3 | | IL-12R-BETA12 | | |
Export aliases for IL12RB1 gene to outside databasesPrevious GC identifers: GC19M018664 GC19M018562 GC19M018015 GC19M018031 GC19M018030 GC19M017735 |
Summaries
for IL12RB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IL12RB1:
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptorsuperfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. Thecoexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites andreconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in theimmunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcriptvariants of this gene encoding distinct isoforms have been reported. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: I12R1_HUMAN, P42701Function: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also withIL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation ofthe Jak-Stat signaling cascade
Gene Wiki entry for IL12RB1 (Interleukin 12 receptor, beta 1 subunit)
|
Genomic Views
for IL12RB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IL12RB1 gene promoter:
Bach1 STAT1 XBP-1 Meis-1b HEN1 HSF2 STAT3 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for IL12RB1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL12RB1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.1 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.1IL12RB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M018170: view genomic region
(about GC identifiers)
Start:
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18,170,371 bp from pter |
End:
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18,197,697 bp from pter |
Size:
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27,327 bases |
Orientation:
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minus strand |
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Proteins
for IL12RB1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: I12R1_HUMAN, P42701 (See
protein sequence)Recommended Name: Interleukin-12 receptor subunit beta-1 precursor Size: 662 amino acids; 73109 Da
Subunit: Dimer or oligomer; disulfide-linked. Interacts with IL12RB2 to form the high affinity IL12 receptor.Heterodimer with IL23R; in presence of IL23. The heterodimer forms the IL23 receptor
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: A8K308 B2RPF1 B7ZKK3 Q8N6Q7Alternative splicing: 3 isoforms: P42701-1 P42701-2 P42701-3 Explore the universe of human proteins at neXtProt for IL12RB1: NX_P42701
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P42701
IL12RB1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_005526.1 NP_714912.1
ENSEMBL proteins: ENSP00000403103 ENSP00000314425
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
IL12RB1 for ontologies About GeneDecksing
IL12RB1 Antibody Products:
Assay Products for IL12RB1: |
Protein
Domains /
Families
for IL12RB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IL12RB1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P42701ProtoNet protein and cluster: P42701 1 Blocks protein family: IPB003529 Long hematopoietin receptor
UniProtKB/Swiss-Prot: I12R1_HUMAN, P42701Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellulartransport and cell-surface receptor bindingDomain: The box 1 motif is required for JAK interaction and/or activationSimilarity: Belongs to the type I cytokine receptor family. Type 2 subfamilySimilarity: Contains 5 fibronectin type-III domains |
Function
for IL12RB1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: I12R1_HUMAN, P42701Function: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also withIL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation ofthe Jak-Stat signaling cascade Genatlas biochemistry entry for IL12RB1:interleukin 12 receptor subunit B1,heterodimerizing with IL12RB2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL12RB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL12RB1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): IL12RB1 (NM_153701) | |  | Sino Biological Human cDNA Clone for IL12RB1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL12RB1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL12RB1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL12RB1 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
IL12RB1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for IL12RB1:
Animal Models:
Mouse knock-out Il12rb1tm1Jm for IL12RB1
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Il12rb1):
IL12RB1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for IL12RB1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune response IL-12-induced IFN-gamma production | | | 2 | Akt Signaling | | | 3 | Development_PDGF signaling via STATs and NF-kB | | | 4 | Immune response IL-12 signaling pathway | | | 5 | Immune response IL-22 signaling pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 EMD Millipore Pathways for IL12RB1
2  R&D Systems Pathways for IL12RB1
5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL12RB1 (see all 8)
5/6  GeneGo (Thomson Reuters) Pathways for IL12RB1 (see all 6)
3  BioSystems Pathways for IL12RB1
2 
Kegg Pathways (Kegg details for IL12RB1):
IL12RB1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL12RB1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/59 Interacting proteins for IL12RB1 (P427013 ENSP000003144254) via UniProtKB, MINT, STRING, and/or I2D (see all 59)About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001916 | positive regulation of T cell mediated cytotoxicity |
ISS | -- | | GO:0002230 | positive regulation of defense response to virus by host |
ISS | -- | | GO:0002827 | positive regulation of T-helper 1 type immune response |
ISS | -- | | GO:0007165 | signal transduction |
IC | 8943050 | | GO:0018108 | peptidyl-tyrosine phosphorylation |
-- | -- |
IL12RB1 for ontologies About GeneDecksing
|
Drugs & Compounds
for IL12RB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
IL12RB1 for compounds About GeneDecksing
 Browse Tocris compounds for IL12RB1
5 Novoseek chemical compound relationships for IL12RB1 gene About this table
Search CenterWatch for drugs/clinical trials and news about IL12RB1 / I12R1
|
Transcripts
for IL12RB1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IL12RB1 gene (2 alternative transcripts): NM_005535.1 NM_153701.1 Unigene Cluster for IL12RB1: Interleukin 12 receptor, beta 1 Hs.567294 [show with all ESTs]Unigene Representative Sequence: BX6472212 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000430026(uc002nhw.1 uc010xqb.1 uc002nhx.1) ENST00000322153(uc002nhy.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL12RB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL12RB1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): IL12RB1 (NM_153701) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL12RB1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL12RB1 |
Additional cDNA sequence: AK225919.1 AK290423.1 BC029121.1 BC137404.1 BC137406.1 BX647221.1 U03187.1 4 DOTS entries: DT.105004 DT.95264404 DT.121412285 DT.91647298 24/27 AceView cDNA sequences (see all 27): NM_005535 AA917405 BQ027636 BM920883 NM_153701 U03187 BX281700 CA306262 AA353168 AI637915 CA308107 BI761918 BC029121 CA306092 BQ213225 BQ059098 AA311943 BI911318 AV764573 BI908302 BE244068 BX647221 BE244073 AW951031
GeneLoc Exon Structure
|
Expression
for IL12RB1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IL12RB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See IL12RB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL12RB1
SOURCE GeneReport for Unigene cluster: Hs.567294
SABiosciences Expression via Pathway-Focused PCR Arrays including IL12RB1: | Cell Surface Markers in human mouse rat | | Th17 Response in human mouse rat | | Interferons & Receptors in human mouse rat | | T-cell & B-cell Activation in human mouse rat | | Inflammatory Response & Autoimmunity 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL12RB1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL12RB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL12RB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL12RB1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL12RB1 |
Orthologs
for IL12RB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IL12RB1 gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for IL12RB1 (if available)
TreeFam Gene Tree for IL12RB1 (if available) |
Paralogs
for IL12RB1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IL12RB1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IL12RB1 (18170371 - 18197697 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IL12RB1: --
Human Gene Mutation Database (HGMD): IL12RB1
Locus Specific Mutation Databases (LSDB): IL12RB1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL12RB1 |
|
Disorders
/ Diseases
for IL12RB1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IL12RB1 for disorders About GeneDecksing
OMIM gene information: 601604
OMIM disorders: 209950
UniProtKB/Swiss-Prot: I12R1_HUMAN, P42701
Defects in IL12RB1 are a cause of Mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; alsoknown as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illnesscaused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmentalnon-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely causesevere clinical disease in individuals with susceptibility to mycobacterial infections, with the exception ofSalmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is theimpairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die ofoverwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later inlife, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous diseasewith autosomal recessive, autosomal dominant or X-linked inheritance
20/68  diseases for IL12RB1 (see all 68): About MalaCardsmycobacterial and salmonella infections mycobacterium avium complex disease subacute sclerosing panencephalitis mycobacterium fortuitum
immunodeficiency tropical spastic paraparesis spastic paraparesis mycobacterial infection
common variable immunodeficiency interleukin receptor lepromatous leprosy severe acute respiratory syndrome
bcg infection primary biliary cirrhosis lupus erythematosus nocardiosis
sarcoidosis systemic lupus erythematosus allergic rhinitis myocarditis
1 disease from the University of Copenhagen DISEASES database for IL12RB1:Tuberculosis 10/23 Novoseek disease relationships for IL12RB1 gene (see all 23) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| mycobacterial infection |
67.8 |
1 |
11020837 (1) |
| salmonella infections |
45.8 |
2 |
9603733 (1), 11034424 (1) |
| tuberculosis disseminated |
42.8 |
2 |
15736007 (2) |
| immune disorder |
41 |
1 |
12165204 (1) |
| tuberculosis |
38.4 |
9 |
9973527 (2), 20212068 (1), 12856223 (1), 15004750 (1) (see all 7) |
| sarcoidosis pulmonary |
33.6 |
2 |
10508796 (2) |
| sarcoidosis |
32.1 |
5 |
17827837 (2), 15004750 (1), 10508796 (1) |
| tuberculosis pulmonary |
27.8 |
5 |
15243935 (2), 10508796 (2), 18493823 (1) |
| autoimmune diseases |
22.3 |
2 |
11024530 (1), 10900337 (1) |
| immunodeficiency |
18.7 |
2 |
9603733 (1), 17917041 (1) |
Genatlas disease: IL12RB1 susceptibility to BCG,non tuberculous mycobacterial and salmonella infections,with the presence of mature granulomasand a secundary impairment of IFNG production
Genetic Association Database (GAD): IL12RB1
Human Genome Epidemiology (HuGE) Navigator: IL12RB1 (49 documents)
Export disorders for IL12RB1 gene to outside databases
|
Publications
for IL12RB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IL12RB1 gene, integrated from 9 sources (see all 219):
(articles sorted by number of sources associating them with IL12RB1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Association of the IL12RB1 promoter polymorphisms with increased risk of atopic dermatitis and other allergic phenotypes. (PubMed id 16159888)1, 4, 9 Takahashi N....Shirakawa T. (2005)
- Interleukin 12 (IL12B), interleukin 12 receptor (IL12RB1) and interleukin 23 (IL23A) gene polymorphism in systemic lupus erythematosus. (PubMed id 15941730)1, 4, 9 Sanchez E....Martin J. (2005)
- Missense mutations of the interleukin-12 receptor beta 1(IL12RB1) and interferon-gamma receptor 1 (IFNGR1) genes are not associated with susceptibility to lepromatous leprosy in Korea. (PubMed id 12743658)1, 4, 9 Lee S.B....Chae G.T. (2003)
- Interleukin-12 receptor beta-1 deficiency in a patient with abdominal tuberculosis. (PubMed id 11424023)1, 2, 9 Altare F.... Casanova J.-L. (2001)
- Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130. (PubMed id 7911493)1, 2, 9 Chua A.O....Gubler U. (1994)
- Association study between interleukin-12 receptor beta1/beta2 genes and type 1 diabetes or asthma in the Japanese population. (PubMed id 12719941)1, 4, 9 Bassuny W.M....Hara T. (2003)
- A receptor for the heterodimeric cytokine IL-23 is composed of IL- 12Rbeta1 and a novel cytokine receptor subunit, IL-23R. (PubMed id 12023369)1, 2, 9 Parham C.... Moore K.W. (2002)
- Assignment of IL12RB1 and IL12RB2, interleukin-12 receptor beta 1 and beta 2 chains, to human chromosome 19 band p13.1 and chromosome 1 band p31.2, respectively, by in situ hybridization. (PubMed id 9284929)1, 3, 9 Yamamoto K....Miyasaka N. (1997)
- A functional interleukin 12 receptor complex is composed of two beta- type cytokine receptor subunits. (PubMed id 8943050)1, 2, 9 Presky D.H.... Gubler U. (1996)
- Association between IFNA genotype and the risk of sarcoidosis. (PubMed id 15004750)1, 4, 9 Akahoshi M....Shirakawa T. (2004)
|
External Searches for IL12RB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IL12RB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IL12RB1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IL12RB1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IL12RB1 | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for IL12RB1 | Genetics and Cytogenetics in Oncology and Haematology | | IL12RB1base | http://bioinf.uta.fi/IL12RB1base/ | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/IL12RB1 | | SeattleSNPs | http://pga.gs.washington.edu/data/il12rb1/ |
|
| | |
About This Section
| Patent Information for IL12RB1 gene:
Search GeneIP for patents involving IL12RB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IL12RB1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for IL12RB1 | | OriGene shRNA RFP for IL12RB1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL12RB1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL12RB1 | | | OriGene Protein Over-expression Lysate for IL12RB1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IL12RB1 | | OriGene 3'-UTR Clone for IL12RB1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL12RB1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL12RB1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for IL12RB1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IL12RB1 | | OriGene Custom Protein Services for IL12RB1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL12RB1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL12RB1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL12RB1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL12RB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL12RB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL12RB1 |
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| | | | Search Tocris compounds for IL12RB1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL12RB1 |
|  |  |  | | | | ThermoFisher Antibodies for IL12RB1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL12RB1 |
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