Aliases for IL12B Gene
- Interleukin 12B 2 3
- Interleukin 12B (Natural Killer Cell Stimulatory Factor 2, Cytotoxic Lymphocyte Maturation Factor 2, P40) 2 3
- Cytotoxic Lymphocyte Maturation Factor 40 KDa Subunit 3 4
- NK Cell Stimulatory Factor Chain 2 3 4
- Interleukin-12 Beta Chain 2 3
- IL-12 Subunit P40 3 4
- CLMF P40 3 4
- IL-12B 3 4
- NKSF2 3 4
- Natural Killer Cell Stimulatory Factor, 40 KD Subunit 3
- Natural Killer Cell Stimulatory Factor-2 2
- Cytotoxic Lymphocyte Maturation Factor 2 2
- Natural Killer Cell Stimulatory Factor 2
External Ids for IL12B Gene
Previous HGNC Symbols for IL12B Gene
Previous GeneCards Identifiers for IL12B Gene
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL12B Gene
IL12B (Interleukin 12B) is a Protein Coding gene. Diseases associated with IL12B include mendelian susceptibility to mycobacterial diseases due to complete il12b deficiency and familial atypical mycobacteriosis, il12b-related. Among its related pathways are TGF-Beta Pathway and Akt Signaling. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity.
UniProtKB/Swiss-Prot for IL12B Gene
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.