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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL12B Gene

protein-coding   GIFtS: 63
GCID: GC05M158741

Interleukin 12B (Natural Killer Cell Stimulatory Factor...


(Previous symbol: NKSF2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 12B (Natural Killer Cell Stimulatory Factor 2, Cytotoxic
Lymphocyte Maturation Factor 2, P40)1 2
     Natural Killer Cell Stimulatory Factor1
NKSF21 2 3 5     Natural Killer Cell Stimulatory Factor-21
Interleukin-12 Beta Chain1 2     p401
Cytotoxic Lymphocyte Maturation Factor 40 KDa Subunit2 3     Subunit P401
IL-12B2 3     CLMF2
CLMF P402 3     CLMF22
IL-12 Subunit P402 3     NKSF2
NK Cell Stimulatory Factor Chain 22 3     IL12, Subunit P402
40 KD Subunit1     Interleukin 12, P402
IL121     Interleukin-12 Subunit Beta2
Cytotoxic Lymphocyte Maturation Factor 21     Natural Killer Cell Stimulatory Factor, 40 KD Subunit2
Interleukin 121     

External Ids:    HGNC: 59701   Entrez Gene: 35932   Ensembl: ENSG000001133027   OMIM: 1615615   UniProtKB: P294603   

Export aliases for IL12B gene to outside databases

Previous GC identifers: GC05M158596 GC05M159251 GC05M158722 GC05M158674 GC05M153836


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL12B Gene:
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad
array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine
receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by
activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found
to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection
to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients
with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter
polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in
children. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL12B Gene: 
IL12B (interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)) is a protein-coding gene. Diseases associated with IL12B include mendelian susceptibility to mycobacterial diseases due to complete il12b deficiency, and familial atypical mycobacteriosis, il12b-related, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Type I diabetes mellitus. GO annotations related to this gene include protein homodimerization activity and identical protein binding.

UniProtKB/Swiss-Prot: IL12B_HUMAN, P29460
Function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of
NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC
Function: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate
and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues.
IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling
cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23
induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be
important for tumorigenesis

Gene Wiki entry for IL12B (Interleukin-12 subunit beta) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL12B gene promoter:
         STAT5B   MEF-2A   TBP   STAT1   MEF-2   TFIID   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL12B promoter sequence
   Search SABiosciences Chromatin IP Primers for IL12B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL12B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1-q33.1   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q31.1-q33.1

IL12B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL12B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M158741:  view genomic region     (about GC identifiers)

Start:
158,741,791 bp from pter      End:
158,757,895 bp from pter
Size:
16,105 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL12B_HUMAN, P29460 (See protein sequence)
Recommended Name: Interleukin-12 subunit beta precursor  
Size: 328 amino acids; 37169 Da
Subunit: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with
IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer
Subcellular location: Secreted
6/7 PDB 3D structures from and Proteopedia for IL12B (see all 7):
1F42 (3D)        1F45 (3D)        3D85 (3D)        3D87 (3D)        3DUH (3D)        3HMX (3D)    

Explore the universe of human proteins at neXtProt for IL12B: NX_P29460

Explore proteomics data for IL12B at MOPED 

Post-translational modifications:

  • UniProtKB: Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is
    also modified
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P29460

  • IL12B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL12B Protein Expression
    REFSEQ proteins: NP_002178.2  
    ENSEMBL proteins: 
     ENSP00000231228  

    Human Recombinant Protein Products for IL12B: 
    EMD Millipore Purified and/or Recombinant IL12B Protein
    R&D Systems Recombinant & Natural Proteins for IL12B (IL-12/IL-23 p40)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for IL12B
    OriGene Protein Over-expression Lysate for IL12B
    OriGene MassSpec for IL12B 
    OriGene Custom Protein Services for IL12B
    GenScript Custom Purified and Recombinant Proteins Services for IL12B
    Novus Biologicals IL12B Proteins
    Novus Biologicals IL12B Lysate
    Sino Biological Recombinant Protein for IL12B
    Sino Biological Cell Lysate for IL12B 
    ProSpec Recombinant Protein for IL12B
    Cloud-Clone Corp. Proteins for IL12B 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS1673147
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--
    GO:0043514interleukin-12 complex IDA11114383
    GO:0070743interleukin-23 complex IDA11114383

    IL12B for ontologies           About GeneDecksing



    IL12B Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL12B
    R&D Systems Antibodies for IL12B (IL-12/IL-23 p40)
    OriGene Antibodies for IL12B
    OriGene Custom Antibody Services for IL12B
    GenScript Custom Superior Antibodies Services for IL12B
    Novus Biologicals IL12B Antibodies
    Abcam antibodies for IL12B
    Cloud-Clone Corp. Antibodies for IL12B 
    ThermoFisher Antibody for IL12B
    LSBio Antibodies in human, mouse, rat for IL12B 

    Assay Products for IL12B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL12B
    R&D Systems ELISAs for IL12B (IL-12/IL-23 p40)         (see all)
    GenScript Custom Assay Services for IL12B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL12B 
    Cloud-Clone Corp. CLIAs for IL12B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    IL: Interleukins and interleukin receptors

    5/7 InterPro protein domains (see all 7):
     IPR003598 Ig_sub2
     IPR015528 IL_12_beta
     IPR003961 Fibronectin_type3
     IPR003530 Hematopoietin_rcpt_L_F3_CS
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P29460

    ProtoNet protein and cluster: P29460

    2 Blocks protein domains:
    IPB003530 Long hematopoietin receptor
    IPB003598 Immunoglobulin C-2 type


    UniProtKB/Swiss-Prot: IL12B_HUMAN, P29460
    Similarity: Belongs to the type I cytokine receptor family. Type 3 subfamily
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    IL12B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL12B_HUMAN, P29460
    Function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of
    NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC
    Function: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate
    and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues.
    IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling
    cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23
    induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be
    important for tumorigenesis

         Genatlas biochemistry entry for IL12B:
    interleukin 12,beta polypeptide (40kDa),dimerizing with IL12A,secreted by macrophages and dendritic
    cells,stimulating IFNG production,chemotactic molecule for macrophages,antagonizing IL12P70

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004896cytokine receptor activity IEA--
    GO:0005125contributes to cytokine activity IDA1674604
    GO:0005126cytokine receptor binding ----
    GO:0005143contributes to interleukin-12 receptor binding TAS9603733
    GO:0005515protein binding IPI10899108
         
    IL12B for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Il12b):
     cellular  craniofacial  digestive/alimentary  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  respiratory system  skeleton  tumorigenesis 

    IL12B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Il12btm1Jm for IL12B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL12B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL12B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL12B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL12B 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL12B
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate IL12B (see all 12):
    hsa-miR-130a* hsa-miR-3660 hsa-miR-589* hsa-miR-548e hsa-miR-23c hsa-miR-520a-5p hsa-miR-548a-3p hsa-miR-23b
    SwitchGear 3'UTR luciferase reporter plasmidIL12B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL12B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL12B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL12B
    Sirion Biotech Customized adenovirus for overexpression of IL12B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IL12B (see all 6)
    OriGene ORF clones in mouse, rat for IL12B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL12B (NM_002187)
    Sino Biological Human cDNA Clone for IL12B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL12B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL12B
    Sirion Biotech Customized lentivirus for stable overexpression of IL12B 
                         Customized lentivirus expression plasmids for stable overexpression of IL12B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL12B
    Search LifeMap BioReagents cell lines for IL12B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL12B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL12B About   (see all 28)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Allograft rejection
    Allograft rejection0.69
    THC Differentiation Pathway0.37
    Type I diabetes mellitus0.69
    3Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Chagas disease (American trypanosomiasis)0.33
    Toll-like receptor signaling pathway0.93
    4IL27-mediated signaling events
    IL27-mediated signaling events0.38
    Th1 Differentiation0.38
    5Development PDGF signaling via STATs and NF-kB
    Immune response IL-23 signaling pathway0.91
    IL23-mediated signaling events0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for IL12B
        Immune response IL-23 signaling pathway
    Immune response IL-12-induced IFN-gamma production
    Immune response IL-22 signaling pathway
    Immune response IL-12 signaling pathway

    3 R&D Systems Pathways for IL12B
        IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th1 Differentiation
    Th17 Differentiation

    5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL12B (see all 28)
        THC Differentiation Pathway
    MSP-RON Signaling
    TRAF Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer

    5/6 GeneGo (Thomson Reuters) Pathways for IL12B (see all 6)
        Immune response IL-12 signaling pathway
    Immune response IL-22 signaling pathway
    Cytokine production by Th17 cells in CF (Mouse model)
    Immune response IL-12-induced IFN-gamma production
    Cytokine production by Th17 cells in CF

    5 BioSystems Pathways for IL12B
        Cytokines and Inflammatory Response
    Toll-like receptor signaling pathway
    IL23-mediated signaling events
    IL12-mediated signaling events
    IL27-mediated signaling events



    5/19         Kegg Pathways  (Kegg details for IL12B) (see all 19):
        Cytokine-cytokine receptor interaction
    Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    Jak-STAT signaling pathway
    Type I diabetes mellitus


    IL12B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL12B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/57 Interacting proteins for IL12B (P294601, 3 ENSP000002312284) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL12AP294591, 3, ENSP000003032314EBI-1029614,EBI-1029636 I2D: score=5 STRING: ENSP00000303231
    IL12RB1P427013, ENSP000003144254I2D: score=3 STRING: ENSP00000314425
    IL23RQ5VWK53, ENSP000003213454I2D: score=1 STRING: ENSP00000321345
    IRF5Q135683, ENSP000003497704I2D: score=1 STRING: ENSP00000349770
    IL23AQ9NPF73, ENSP000002285344I2D: score=5 STRING: ENSP00000228534
    About this table

    Gene Ontology (GO): 5/52 biological process terms (GO ID links to tree view) (see all 52):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001916positive regulation of T cell mediated cytotoxicity ISS--
    GO:0002230positive regulation of defense response to virus by host ISS--
    GO:0002827positive regulation of T-helper 1 type immune response ISS--
    GO:0002860positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IDA7903063
    GO:0002862negative regulation of inflammatory response to antigenic stimulus IEA--

    IL12B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL12B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IL12B

    2 DrugBank Compounds for IL12B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-Mercapto-2-Nitro-Benzoic Acid-- 15139-21-6target--17139284 17016423
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423

    10/28 Novoseek inferred chemical compound relationships for IL12B gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    il-12 88.4 11 10525320 (1), 20350312 (1), 15860229 (1), 16754651 (1) (see all 9)
    il 10 49 4 16519741 (3), 17653830 (1)
    rantes 46.4 7 10570261 (2), 16388854 (1), 19220953 (1), 15182255 (1) (see all 5)
    lipoteichoic acid 41.2 4 17567674 (2), 8675286 (1), 15146415 (1)
    sb 203580 33.9 8 12603851 (1), 10570261 (1), 12704121 (1), 12847227 (1) (see all 5)
    poly(i-c) 26.9 2 12845500 (1)
    polyinosinic-polycytidylic acid 24.6 1 12845500 (1)
    imiquimod 16.7 2 10480263 (1), 10607486 (1)
    ccl4 15.1 1 15182255 (1)
    pd 98,059 13.9 4 12603851 (1), 12704121 (1)

    Search CenterWatch for drugs/clinical trials and news about IL12B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL12B gene: 
    NM_002187.2  

    Unigene Cluster for IL12B:

    Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
    Hs.674  [show with all ESTs]
    Unigene Representative Sequence: NM_002187
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000231228(uc003lxr.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL12B
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate IL12B (see all 12):
    hsa-miR-130a* hsa-miR-3660 hsa-miR-589* hsa-miR-548e hsa-miR-23c hsa-miR-520a-5p hsa-miR-548a-3p hsa-miR-23b
    SwitchGear 3'UTR luciferase reporter plasmidIL12B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL12B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL12B
    Clone
    Products:
         
    OriGene clones in human, mouse for IL12B (see all 6)
    OriGene ORF clones in mouse, rat for IL12B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL12B (NM_002187)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL12B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL12B
    Sirion Biotech Customized lentivirus for stable overexpression of IL12B 
                         Customized lentivirus expression plasmids for stable overexpression of IL12B 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IL12B
    OriGene qSTAR qPCR primer pairs in human, mouse for IL12B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL12B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL12B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL12B

    Additional mRNA sequence: 

    AF180563.1 AY046592.1 AY046593.1 BC067498.1 BC067499.1 BC067500.1 BC067501.1 BC067502.1 
    BC074723.2 EF173865.1 M65272.1 M65290.1 

    1 DOTS entry:

    DT.303521 

    22 AceView cDNA sequences:

    BC074723 AF180563 NM_002187 M65272 BC067500 BC067499 AY046593 BC067501 
    BC067502 M65290 BC067498 CD559605 CD559607 CD559449 CD559450 CD559453 
    CD559448 CD559451 CD559602 CD559604 CK130264 CD559603 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL12B expression in normal human tissues (normalized intensities)      IL12B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IL12B Expression
    About this image


    IL12B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
             rectum ; glandular cells   
     
     Bone (Muscoskeletal System)
             Bone marrow-derived mesenchymal stem cells
     
     Uterus (Reproductive System)
             uterus, pre-menopause ; glandular cells   
     
     Fibroblast (Uncategorized)
             skin ; fibroblasts   

    See IL12B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL12B

    SOURCE GeneReport for Unigene cluster: Hs.674
        SABiosciences Expression via Pathway-Focused PCR Arrays including IL12B (see all 20): 
              HIV Host Response in human mouse rat
              Antiviral Response in human mouse rat
              Interferons & Receptors in human mouse rat
              Inflammasomes in human mouse rat
              T-cell & B-cell Activation in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL12B gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il12b1 , 5 interleukin 12b1, 5 75.47(n)1
    69.57(a)1
      11 (25.94 cM)5
    161601  NM_008352.21  NP_032378.11 
     444000635 
    chicken
    (Gallus gallus)
    Aves IL12B1 interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) less 56.28(n)
    46.89(a)
      404671  NM_213571.1  NP_998736.1 
    lizard
    (Anolis carolinensis)
    Reptilia IL12B6
    interleukin 12B (natural killer cell stimulatory f...
    27(a)
    1 ↔ 1
    2(121555267-121603327)
    zebrafish
    (Danio rerio)
    Actinopterygii il12ba1 interleukin 12Ba 46.42(n)
    34.44(a)
      445373  NM_001007108.1  NP_001007109.1 


    ENSEMBL Gene Tree for IL12B (if available)
    TreeFam Gene Tree for IL12B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/409 SNPs in IL12B are shown (see all 409)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs343247651,2
    C,F--158742208(+) AATCA-/TTTTTT 1 -- ut313Minor allele frequency- T:0.33NA CSA 6
    rs32131121,2
    C--158742987(-) AAACG-/TTTTTT 1 -- ut313Minor allele frequency- T:0.03NS NA 188
    rs32131111,2
    C,F--158743230(-) GAAGG-/GCCTGG 1 -- int13Minor allele frequency- G:0.34NS NA 136
    rs597370691,2
    C--158751103(+) TTATT-/ATTTTTAG 1 -- cds10--------
    rs346450921,2
    C--158751104(+) TATTA-/ATTTTATT 1 -- cds10--------
    rs614540791,2
    C--158755350(+) AGACA-/CAGGCTT 1 -- int10--------
    rs104762891,2
    C,F,H--158969386(+) GCTTCC/TACCCC 1 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs1905190351,2
    --158969463(+) CCCCTA/GAGCTC 1 -- ds50010--------
    rs1494414921,2
    --158969610(+) ACTCAA/GATCAG 1 -- ds50010--------
    rs1448178481,2
    --158969731(+) AGAGCA/GCACAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for IL12B (158741791 - 158757895 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IL12B: --

    Human Gene Mutation Database (HGMD): IL12B

    Locus Specific Mutation Databases (LSDB): IL12B
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for IL12B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 161561   
    OMIM disorders: 209950  600807  
    UniProtKB/Swiss-Prot: IL12B_HUMAN, P29460
  • Mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]: This rare condition confers
    predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin
    (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium
    tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to
    mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The
    pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity
    determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like
    lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with
    tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant
    or X-linked inheritance. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Psoriasis 11 (PSORS11) [MIM:612599]: A common, chronic inflammatory disease of the skin with
    multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees.
    These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the
    dermis and epidermis. Note=Disease susceptibility is associated with variations affecting the gene represented in
    this entry

  • 20/136 diseases for IL12B (see all 136):    About MalaCards
    mendelian susceptibility to mycobacterial diseases due to complete il12b deficiency    familial atypical mycobacteriosis, il12b-related    bcg and salmonella infection, disseminated    multiple sclerosis
    paratyphoid fever    sarcoidosis    cardiac sarcoidosis    measles
    lepromatous leprosy    cystic echinococcosis    cerebral malaria    allergic encephalomyelitis
    silicosis    typhoid fever    polymyalgia rheumatica    hiv/aids
    autoimmune thyroiditis    carotid stenosis    h. pylori infection    leprosy


    IL12B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/51 Novoseek inferred disease relationships for IL12B gene (see all 51)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mycobacterial infection 55.9 3 9722917 (1), 12595896 (1), 17445208 (1)
    necrosis 55.7 34 9856837 (2), 8698475 (1), 12603851 (1), 17727629 (1) (see all 31)
    psoriasis 53.4 20 15102082 (3), 12413772 (1), 18800148 (1), 20476959 (1) (see all 14)
    multiple sclerosis 40.5 5 15579375 (1), 11110796 (1), 12325088 (1), 18082575 (1) (see all 5)
    autoimmune diseases 37.6 2 15993716 (1), 18587636 (1)
    hypersensitivity contact 35.6 2 9605132 (2)
    malaria cerebral 33.3 7 12424623 (2), 20003322 (2), 14573655 (1), 15175646 (1)
    tumors 31.9 31 9856837 (2), 8698475 (1), 12603851 (1), 19330264 (1) (see all 28)
    tuberculosis 31.4 8 16367946 (1), 18522869 (1), 17392024 (1), 14551880 (1) (see all 8)
    inflammatory bowel diseases 30.1 4 11515847 (2), 19817673 (1), 18082575 (1)

    Genatlas disease: IL12B
    susceptibility to BCG,non tuberculous mycobacterial and salmonella infections,with the presence of mature
    granulomas and a secundary impairment of IFNG production

    Genetic Association Database (GAD): IL12B
    Human Genome Epidemiology (HuGE) Navigator: IL12B (190 documents)

    Export disorders for IL12B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL12B gene, integrated from 9 sources (see all 669):
    (articles sorted by number of sources associating them with IL12B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. (PubMed id 1673147)1, 2, 3, 9 Wolf S.F....Perussia B. (1991)
    2. Genetic Variants of the IL-23R Pathway: Association with Psoriatic Arthritis and Psoriasis Vulgaris, but No Specific Risk Factor for Arthritis. (PubMed id 18800148)1, 2, 4, 9 Huffmeier U....Reis A. (2008)
    3. Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. (PubMed id 17587057)1, 2, 4, 9 Capon F.... Nestle F.O. (2007)
    4. Lack of association between IL-12B gene polymorphism and autoimmune thyroid disease in Japanese patients. (PubMed id 15644581)1, 4, 9 Ikeda Y....Hashimoto K. (2004)
    5. Interleukin 12 (IL12B), interleukin 12 receptor (IL12RB1) and interleukin 23 (IL23A) gene polymorphism in systemic lupus erythematosus. (PubMed id 15941730)1, 4, 9 Sanchez E....Martin J. (2005)
    6. Associations between IL12B polymorphisms and tuberculosis in the Hong Kong Chinese population. (PubMed id 15295696)1, 4, 9 Tso H.W....Chiang A.K. (2004)
    7. The 3'UTR 1188 A/C polymorphism in the interleukin-12p40 gene (IL-12B) is associated with lepromatous leprosy in the west of Mexico. (PubMed id 18485489)1, 4, 9 Alvarado-Navarro A....Fafutis-Morris M. (2008)
    8. Interleukin 12 (IL12B) and interleukin 12 receptor (IL12RB1) gene polymorphisms in rheumatoid arthritis. (PubMed id 15993716)1, 4, 9 Orozco G....Martin J. (2005)
    9. Polymorphisms in the IL-12B gene and outcome of HCV infection. (PubMed id 15871664)1, 4, 9 Houldsworth A....Cramp M.E. (2005)
    10. Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infection. (PubMed id 15464247)1, 4, 9 Mueller T....Berg T. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3593 HGNC: 5970 AceView: IL12B Ensembl:ENSG00000113302 euGenes: HUgn3593
    ECgene: IL12B Kegg: 3593 H-InvDB: IL12B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL12B Pharmacogenomics, SNPs, Pathways
    IL12Bbasehttp://bioinf.uta.fi/IL12Bbase/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/IL12B
    SeattleSNPshttp://pga.gs.washington.edu/data/il12b/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL12B gene:
    Search GeneIP for patents involving IL12B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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