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IL12B Gene

protein-coding GIFtS: 66

GC05M158674

interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: NKSF2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CLMF ^¹, ²
CLMF2 ^¹, ²
IL-12B ^¹, ², ³
NKSF ^¹, ²
NKSF2 ^², ³, ⁵
OTTHUMP00000160820 ^²

Descriptions
CLMF p40 ^³
Cytotoxic lymphocyte maturation factor 40 kDa subunit ^³
IL-12 subunit p40 ^³
IL12, subunit p40 ^²
NK cell stimulatory factor chain 2 ^³
interleukin 12, p40 ^²
interleukin 12B ^²
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) ^²
interleukin-12 beta chain ^²
natural killer cell stimulatory factor, 40 kD subunit ^²

External Ids
HGNC: 5970¹
Entrez Gene: 3593²
UniProtKB: P29460³
Ensembl: ENSG00000113302⁷

Search outside databases for aliases for IL12B gene

Previous GC identifers: GC05M158596 GC05M159251 GC05M158722

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IL12B:

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells,

and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer

composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit

encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential

inducer of Th1 cells development. This cytokine has been found to be important for sustaining a

sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular

pathogen. Overexpression of this gene was observed in the central nervous system of patients with

multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease.

The promoter polymorphism of this gene has been reported to be associated with the severity of

atopic and non-atopic asthma in children. [provided by RefSeq]

UniProtKB/Swiss-Prot: IL12B_HUMAN, P29460

Function: Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which

functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to

infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of

IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive

T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune

inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important

for tumorigenesis

Gene Wiki entry for IL12B (Interleukin-12_subunit_beta)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IL12B gene

Entrez Gene cytogenetic band: 5q31.1-q33.1 Ensembl cytogenetic band: 5q33.3 HGNC cytogenetic band: 5q31.1-q33.1

IL12B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M158674: (about GC identifiers)

Start:	158,674,369 bp from pter
End:	158,690,059 bp from pter
Size:	15,691 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_023133.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: IL12B_HUMAN, P29460 (See protein sequence)

Recommended Name: Interleukin-12 subunit beta precursor

Size: 328 amino acids; 37169 Da

Subunit: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.

Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also

secreted as a monomer

Subcellular location: Secreted

PDB structures from and Proteopedia :

1F42 (3D)

1F45 (3D)

3D85 (3D)

3D87 (3D)

3DUH (3D)

Post-translational modifications:

Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the

wild-type protein is also modified¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002178.2

ENSEMBL proteins:

ENSP00000231228

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant IL12B Protein
	Sigma-Aldrich Proteins for IL12B
	R&D Systems Recombinant & Natural Proteins for IL12B (IL-12/IL-23 p40)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IL12p70, IL12B, IL12 p35 + IL12 p70, IL12 p70, IL12, IL12 p40 + IL12 p70, IL12 p40)
	Human Recombinant Proteins from Abnova (IL12B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0016020	membrane	IEA	--
GO:0043514	interleukin-12 complex	IDA	1674604

About this table

Antibodies for IL12B:

	Invitrogen Antibodies for IL12B
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for IL12B
	R&D Systems Antibodies for IL12B (IL-12/IL-23 p40)
	Antibodies from Abcam (IL12p70, IL12B, IL12 p35 + IL12 p70, IL12 p70, IL12, IL12 p40 + IL12 p70, IL12 p40), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IL12B)
	Novus Biologicals Antibodies for IL12B

Assays for IL12B:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of IL12B
	R&D Systems ELISAs for IL12B (IL-12/IL-23 p40) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P29460

ProtoNet protein and cluster: P29460

2 Blocks protein families:

IPB003530 Long hematopoietin receptor

IPB003598 Immunoglobulin C-2 type

UniProtKB/Swiss-Prot: IL12B_HUMAN, P29460

Similarity: Belongs to the type I cytokine receptor family. Type 3 subfamily

Similarity: Contains 1 fibronectin type-III domain

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IL12B)
		Millipore RNAi Products for the Analysis of IL12B Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (IL12B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002187

Applied Biosystems Silencer® siRNAs for IL12B

Sigma-Aldrich siRNA and siRNA Panels for IL12B

Sigma-Aldrich shRNA Panels and shRNA for IL12B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002187
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002187
untagged cDNA clone in CMV expression vector: NM_002187

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002187

UniProtKB/Swiss-Prot: IL12B_HUMAN, P29460

Function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic

activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by

resting PBMC

Function: Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which

functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to

infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of

IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive

T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune

inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important

for tumorigenesis

Genatlas biochemistry entry for IL12B:

interleukin 12,beta polypeptide (40kDa),dimerizing with IL12A,secreted by macrophages and dendritic

cells,stimulating IFNG production,chemotactic molecule for macrophages,antagonizing IL12P70

6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Il12b):

digestive/alimentary	hematopoietic system	homeostasis/metabolism	immune system	respiratory system
tumorigenesis

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	TAS	9789052
GO:0004896	cytokine receptor activity	IEA	--
GO:0005125	contributes to cytokine activity	IDA	1674604
GO:0005143	interleukin-12 receptor binding	TAS	1674604
GO:0005515	protein binding	IPI	10899108

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for IL12B (Your Favorite Gene powered by Ingenuity) (see all 6 )

T Helper Cell Differentiation
Role of Cytokines in Mediating Communication between Immune Cells
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
Type I Diabetes Mellitus Signaling
IL-12 Signaling and Production in Macrophages

GeneDecks IL12B for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for IL12B

5/153 Interacting proteins for IL12B (P29460¹ ENSP00000231228³) via UniProtKB, MINT, and/or STRING (see all 153 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL12A	P29459¹, ENSP00000303231³	EBI-1029614, EBI-1029636 STRING (score=.999)
IL23A	ENSP00000228534³	STRING (score=.999)
IFNG	ENSP00000229135³	STRING (score=.998)
IL12RB1	ENSP00000221270³	STRING (score=.998)
IL12RB2	ENSP00000262345³	STRING (score=.998)

About this table

5/17 Gene Ontology (GO) biological process terms (links to tree view) (see all 17 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002323	natural killer cell activation during immune response	IEA	--
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IDA	7903063
GO:0007050	cell cycle arrest	IDA	16942485
GO:0007166	cell surface receptor linked signal transduction	IEA	--
GO:0010224	response to UV-B	IDA	8992506

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IL12B
10/15 Novoseek chemical compound relationships for IL12B gene (see all 15 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
il-12	87.11	10	10525320 (1), 15860229 (1), 16754651 (1), 11356252 (1) (see all 8)
rantes	47.76	7	10570261 (2), 16388854 (1), 19220953 (1), 15182255 (1) (see all 5)
il 10	45.78	4	16519741 (3), 17653830 (1)
lipoteichoic acid	42.94	4	17567674 (2), 8675286 (1), 15146415 (1)
poly(i-c)	27.89	2	12845500 (1)
ccl4	16.93	1	15182255 (1)
pd 98,059	15.70	4	12603851 (1), 12704121 (1)
nitric oxide	12.82	26	17291992 (7), 12424623 (2), 14573655 (2), 12857749 (1) (see all 11)
peptidoglycan	9.54	2	15860229 (1)
lipid	2.49	1	19438591 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IL12B)
		Millipore RNAi Products for the Analysis of IL12B Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (IL12B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002187

Sigma-Aldrich siRNA and siRNA Panels for IL12B

Sigma-Aldrich shRNA Panels and shRNA for IL12B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002187

REFSEQ mRNAs for IL12B gene:

NM_002187.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002187

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002187
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002187
                                 untagged cDNA clone in CMV expression vector: NM_002187

Additional cDNA sequence:

AF180563.1 AY046592.1 AY046593.1 BC067498.1 BC067499.1 BC067500.1 BC067501.1 BC067502.1

BC074723.2 EF173865.1 M65272.1 M65290.1

1 DOTS entry:

DT.303521

22 AceView cDNA sequences:

BC067500 AY046593 M65272 BC067502 AF180563 BC067499 BC067501 BC074723

NM_002187 CD559453 CD559607 CD559449 CD559605 CD559450 BC067498 M65290

CD559448 CD559602 CD559451 CD559603 CK130264 CD559604

highest scoring ESTs for IL12B:

M65272 M65290 AF180563 AY046593 BC067498 BC067499 BC067500 BC067501 BC067502 BC074723

Unigene Cluster for IL12B:

Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

Hs.674 [show with all ESTs]

Unigene Representative Sequence: NM_002187

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000231228

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IL12B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IL12B

¹ / ² / ³

3 probe-sets matching IL12B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
563_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M65290	0.80	1.00	0.91	1
207901_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002187	0.60	1.00	0.82	1
207901_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.674
Expression variation in blood from EXPOLDB for IL12B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IL12B gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IL12B¹	--	interleukin 12B (natural killer cell stimulatory factor more	87.69(n) 85.23(a)	403976 NM_001003292.1 NP_001003292.1
chimpanzee (Pan troglodytes)	IL12B¹	--	interleukin 12B (natural killer cell stimulatory factor more	99.39(n) 99.39(a)	471723 XM_527101.2 XP_527101.2
cow (Bos taurus)	IL12B¹	--	interleukin 12B (natural killer cell stimulatory factor more	88.65(n) 85.45(a)	281857 NM_174356.1 NP_776781.1
rat (Rattus norvegicus)	Il12b¹	--	interleukin 12b	76.71(n) 69.25(a)	64546 NM_022611.1 NP_072133.1
mouse (Mus musculus)	Il12b^{1, 5}	11 (19.00 cM)⁵	interleukin 12b^{1, 5}	75.47(n)¹ 69.57(a)¹	16160¹ NM_008352.2¹ NP_032378.1¹ AF128214⁵ AF128215⁵ (see all 20)

About this table Species with no ortholog for IL12B

ENSEMBL Gene Tree for IL12B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/153 NCBI SNPs in IL12B are shown (see all 153 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 90)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3212227^1,2	A,C,F,H,O	158675528(-)	`TAGTTA/CGATGC`	1	--	ut3¹		16	NA NS MN CSAM EA EU WA	1142
	rs1368439^1,2	C,F,H	158674592(+)	`TCACAT/GGGCTG`	1	--	ut3¹		21	NA NS MN EU EA WA	1831
	rs3213120^1,2	C,F,H	158675686(-)	`TCCAGG/ATTCTG`	1	--	ut3¹		7	NS EU EA WA NA	544
	rs3213119^1,2	C,F,H	158676366(-)	`CCACGG/TTCATC`	1	V/F	mis¹ ese³		16	NS EU EA WA MN CSAM NA	1358
	rs3213096^1,2	C,F,H	158682907(-)	`ATGTCG/ATAGAA`	1	I/V	mis¹		13	NS NA EU EA WA	1068
--	rs3213113^1,2	C,F,H	158675462(-)	`TTGCCA/CTGGGC`	1	--	ut3¹		12	NS MN CSAM EA EU WA NA	962
	rs10045130^1,2	C,H	158680045(+)	`GTCCCC/TTCTGA`	1	G/R	mis¹ ese³		9	EU EA WA MN CSAM	814
--	rs3219202^1,2	F	158675571(-)	`AACGT-/TTTTTT`	1	--	ut3¹		1	NA	100
	rs1805132^1,2	C	158675499(-)	`ATCAGC/ATAATT`	1	--	ut3¹		5	MN CSAM EA	408
	rs10476289^1,2	H	158674120(+)	`GCTTCC/TACCCC`	1	--	ng5¹		4	EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for IL12B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 161561 disorders: 209950 600807

UniProtKB/Swiss-Prot: IL12B_HUMAN, P29460

Defects in IL12B are a cause of mendelian susceptibility to mycobacterial disease (MSMD)

[MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare

condition confers predisposition to illness caused by moderately virulent mycobacterial species,

such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and

by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical

disease in individuals with susceptibility to mycobacterial infections, with the exception of

Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying

MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the

clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like

lesions in early childhood, whereas others develop, later in life, disseminated but curable

infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal

recessive, autosomal dominant or X-linked inheritance

10/51 Novoseek disease relationships for IL12B gene (see all 51 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mycobacterial infection	57.14	3	9722917 (1), 12595896 (1), 17445208 (1)
necrosis	54.95	30	9856837 (2), 8698475 (1), 12603851 (1), 17727629 (1) (see all 27)
psoriasis	50.42	14	15102082 (3), 12413772 (1), 18800148 (1), 18650833 (1) (see all 10)
multiple sclerosis	39.63	5	15579375 (1), 11110796 (1), 12325088 (1), 18082575 (1) (see all 5)
hypersensitivity contact	37.24	2	9605132 (2)
autoimmune diseases	33.19	2	15993716 (1), 18587636 (1)
tumors	32.17	27	9856837 (2), 8698475 (1), 12603851 (1), 19330264 (1) (see all 24)
inflammation	28.68	11	11157054 (3), 12702051 (1), 15007350 (1), 13679443 (1) (see all 8)
tuberculosis	27.12	8	16367946 (1), 18522869 (1), 17392024 (1), 14551880 (1) (see all 8)
inflammatory bowel diseases	26.62	3	11515847 (2), 18082575 (1)

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1 PharmGKB disease relationship for IL12B gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Asthma	GN	15322986

About this table

Genatlas disease: IL12B

susceptibility to BCG,non tuberculous mycobacterial and salmonella infections,with the presence of

mature granulomas and a secundary impairment of IFNG production

Human Gene Mutation Database: IL12B
Genetic Association Database: IL12B
Human Genome Epidemiology Navigator: IL12B (114 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

New Treatment for Psoriasis Is Highly Effective

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/469 PubMed articles for IL12B gene (see all 469 ):

The IL12B gene is associated with asthma. (PubMed id 15322986)^{1, 3, 6, 7} Randolph A.G....Weiss S.T. (2004)
Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. (PubMed id 1673147)^{1, 2, 3, 4} Wolf S.F....Perussia B. (1991)
Lack of association between IL-12B gene polymorphism and autoimmune thyroid disease in Japanese patients. (PubMed id 15644581)^{1, 3, 6} Ikeda Y....Hashimoto K. (2004)
Interleukin 12 (IL12B), interleukin 12 receptor (IL12RB1) and interleukin 23 (IL23A) gene polymorphism in systemic lupus erythematosus. (PubMed id 15941730)^{1, 3, 6} Sanchez E....Martin J. (2005)
Associations between IL12B polymorphisms and tuberculosis in the Hong Kong Chinese population. (PubMed id 15295696)^{1, 3, 6} Tso H.W....Chiang A.K. (2004)
Interleukin 12 (IL12B) and interleukin 12 receptor (IL12RB1) gene polymorphisms in rheumatoid arthritis. (PubMed id 15993716)^{1, 3, 6} Orozco G....Martin J. (2005)
Polymorphisms in the IL-12B gene and outcome of HCV infection. (PubMed id 15871664)^{1, 3, 6} Houldsworth A....Cramp M.E. (2005)
Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infection. (PubMed id 15464247)^{1, 3, 6} Mueller T....Berg T. (2004)
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. (PubMed id 1674604)^{1, 3, 4} Gubler U....Gately M.K. (1991)
Associations of the IL12B promoter polymorphism in longitudinal data from asthmatic patients 7 to 42 years of age. (PubMed id 15007350)^{1, 3, 6} Khoo S.K....Le Souef P. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3593	HGNC: 5970	AceView: IL12B	Ensembl:ENSG00000113302	euGenes: HUgn3593
ECgene: IL12B	H-InvDB: IL12B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
IL12Bbase	http://bioinf.uta.fi/IL12Bbase/
GeneReviews	http://www.genetests.org/query?gene=IL12B
SeattleSNPs	http://pga.gs.washington.edu/data/il12b/

Licensable Technologies for IL12B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IL12B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IL12B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IL12B		Antibodies for IL12B
	Explore super-pooled esiRNAs		Proteins for IL12B
	Lentivirus-delivered shRNAs for IL12B		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IL12B)
	Antibodies (IL12B)
	Chimera RNAi (IL12B)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (IL12p70, IL12B, IL12 p35 + IL12 p70, IL12 p70, IL12, IL12 p40 + IL12 p70, IL12 p40)
	Antibodies (IL12p70, IL12B, IL12 p35 + IL12 p70, IL12 p70, IL12, IL12 p40 + IL12 p70, IL12 p40)

Search OriGene for IL12B

Search Tocris compounds for IL12B

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for IL12B

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
IL12B Gene at Home site.
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IL12B Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for IL12B

Summaries
for IL12B

Genomic Location
for IL12B

Proteins
for IL12B

Protein Domains/
Families
for IL12B

Gene Function
for IL12B

Pathways & Interactions
for IL12B

Drugs & Compounds
for IL12B

Transcripts
for IL12B

Expression
for IL12B

Orthologs
for IL12B

Paralogs
for IL12B

SNPs/Variants
for IL12B

Disorders & Mutations
for IL12B

Medical News
for IL12B

Publications
for IL12B

Search for IL12B

Genome Databases showing IL12B

Other Databases showing IL12B

Specialized Databases showing IL12B

Licensable Technologies
for IL12B

Services
for IL12B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IL12B Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor IL12B

Summariesfor IL12B

Genomic Locationfor IL12B

Proteinsfor IL12B

Protein Domains/Familiesfor IL12B

Gene Functionfor IL12B

Pathways & Interactionsfor IL12B

Drugs & Compoundsfor IL12B

Transcriptsfor IL12B

Expression for IL12B

Orthologsfor IL12B

Paralogsfor IL12B

SNPs/Variantsfor IL12B

Disorders & Mutationsfor IL12B

Medical Newsfor IL12B

Publicationsfor IL12B

Search for IL12B

Genome Databases showing IL12B

Other Databases showing IL12B

Specialized Databases showing IL12B

Licensable Technologiesfor IL12B

Servicesfor IL12B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IL12B

Summaries
for IL12B

Genomic Location
for IL12B

Proteins
for IL12B

Protein Domains/
Families
for IL12B

Gene Function
for IL12B

Pathways & Interactions
for IL12B

Drugs & Compounds
for IL12B

Transcripts
for IL12B

Expression
for IL12B

Orthologs
for IL12B

Paralogs
for IL12B

SNPs/Variants
for IL12B

Disorders & Mutations
for IL12B

Medical News
for IL12B

Publications
for IL12B

Licensable Technologies
for IL12B

Services
for IL12B