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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL12B Gene

protein-coding GIFtS: 63
GCID: GC05M158741

interleukin 12B (natural killer cell stimulatory factor...

(Previous symbol: NKSF2)

Explore 143 diseases affiliated with
IL12B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin 12B (Natural Killer Cell Stimulatory Factor 2, Cytotoxic Lymphocyte Maturation Factor 2, P40)¹ ²		IL-12 Subunit P40² ³
NKSF2¹ ² ³ ⁵		NK Cell Stimulatory Factor Chain 2² ³
IL-12B¹ ² ³		IL12, Subunit P40²
CLMF¹ ²		Interleukin 12, P40²
CLMF2¹ ²		Interleukin-12 Beta Chain²
NKSF¹ ²		Interleukin-12 Subunit Beta²
Cytotoxic Lymphocyte Maturation Factor 40 KDa Subunit² ³		Natural Killer Cell Stimulatory Factor, 40 KD Subunit²
CLMF P40² ³

External Ids:	HGNC: 5970¹	Entrez Gene: 3593²	Ensembl: ENSG00000113302⁷	OMIM: 161561⁵	UniProtKB: P29460³

Export aliases for IL12B gene to outside databases

Previous GC identifers: GC05M158596 GC05M159251 GC05M158722 GC05M158674 GC05M153836

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL12B:

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad

array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine

receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by

activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be

important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an

intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with

multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter

polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in

children. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IL12B_HUMAN, P29460

Function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of

NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC

Function: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and

adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds

to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade,

stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces

autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for

tumorigenesis

Gene Wiki entry for IL12B (Interleukin-12 subunit beta)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_023133.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL12B gene promoter:
STAT5B MEF-2A TBP STAT1 MEF-2 TFIID aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL12B promoter sequence

Search SABiosciences Chromatin IP Primers for IL12B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL12B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1-q33.1 Ensembl cytogenetic band: 5q33.3 HGNC cytogenetic band: 5q31.1-q33.1

IL12B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL12B gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M158741: view genomic region (about GC identifiers)

Start:	158,741,791 bp from pter	End:	158,757,895 bp from pter
Size:	16,105 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL12B_HUMAN, P29460 (See protein sequence)

Recommended Name: Interleukin-12 subunit beta precursor

Size: 328 amino acids; 37169 Da

Subunit: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with

IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer

Subcellular location: Secreted

6/7 PDB 3D structures from and Proteopedia for IL12B (see all 7):

1F42 (3D)

1F45 (3D)

3D85 (3D)

3D87 (3D)

3DUH (3D)

3HMX (3D)

Explore the universe of human proteins at neXtProt for IL12B: NX_P29460

Post-translational modifications:

Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also

modified¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P29460

IL12B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002178.2

ENSEMBL proteins:

ENSP00000231228

Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant IL12B Protein
	R&D Systems Recombinant & Natural Proteins for IL12B (IL-12/IL-23 p40)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): IL12B OriGene Protein Over-expression Lysate: IL12B OriGene Custom Protein Services for IL12B
	GenScript Custom Purified and Recombinant Proteins Services for IL12B
	Novus Biologicals IL12B Proteins Novus Biologicals IL12B Lysate
	Sino Biological Recombinant Protein for IL12B
	ProSpec Recombinant Protein for IL12B
	Uscn Proteins for IL12B

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	TAS	1673147
GO:0005737	cytoplasm	IEA	--
GO:0016020	membrane	IEA	--
GO:0043514	interleukin-12 complex	IDA	11114383
GO:0070743	interleukin-23 complex	IDA	11114383

IL12B for ontologies About GeneDecksing

IL12B Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IL12B
	R&D Systems Antibodies for IL12B (IL-12/IL-23 p40)
	OriGene Antibodies (see all 2): IL12B OriGene Custom Antibody Services for IL12B
	GenScript Custom Superior Antibodies Services for IL12B
	Novus Biologicals IL12B Antibodies
	Abcam antibodies for IL12B
	Uscn Antibodies for IL12B
	ThermoFisher Antibody for IL12B

Assay Products for IL12B:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for IL12B (IL-12/IL-23 p40) (see all)
	GenScript Custom Assay Services for IL12B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IL12B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL12B for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR003598 Ig_sub2

IPR007110 Ig-like_dom

IPR015528 IL_12_beta

IPR003961 Fibronectin_type3

IPR019482 Interleukin-12_bsu_cen-dom

Graphical View of Domain Structure for InterPro Entry P29460

ProtoNet protein and cluster: P29460

2 Blocks protein families:

IPB003530 Long hematopoietin receptor

IPB003598 Immunoglobulin C-2 type

UniProtKB/Swiss-Prot: IL12B_HUMAN, P29460

Similarity: Belongs to the type I cytokine receptor family. Type 3 subfamily

Similarity: Contains 1 fibronectin type-III domain

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IL12B_HUMAN, P29460

Function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of

NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC

Function: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and

adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds

to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade,

stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces

autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for

tumorigenesis

Genatlas biochemistry entry for IL12B:

interleukin 12,beta polypeptide (40kDa),dimerizing with IL12A,secreted by macrophages and dendritic cells,stimulating

IFNG production,chemotactic molecule for macrophages,antagonizing IL12P70

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL12B
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate IL12B (see all 12):
		hsa-miR-130a* hsa-miR-3660 hsa-miR-589* hsa-miR-548e hsa-miR-23c hsa-miR-520a-5p hsa-miR-548a-3p hsa-miR-23b

		SwitchGear 3'UTR luciferase reporter plasmid: IL12B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL12B (see all 7) OriGene shRNA RFP: IL12B OriGene siRNA: IL12B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL12B

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IL12B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL12B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL12B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL12B (NM_002187)
		Sino Biological Human cDNA Clone for IL12B
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL12B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL12B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL12B
		Search LifeMap BioReagents cell lines for IL12B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL12B

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004896	cytokine receptor activity	IEA	--
GO:0005125	contributes to cytokine activity	IDA	1674604
GO:0005126	cytokine receptor binding	--	--
GO:0005143	contributes to interleukin-12 receptor binding	TAS	9603733
GO:0005515	protein binding	IPI	11114383

IL12B for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Il12b^tm1Jm for IL12B
     10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Il12b):

cellular	craniofacial	digestive/alimentary	hematopoietic system	homeostasis/metabolism
immune system	mortality/aging	respiratory system	skeleton	tumorigenesis

IL12B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/26 super-pathways (see all 26) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/12 pathways (see all 12)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

TGF-Beta Pathway

TGF-Beta Pathway	1.00	Regulation of eIF4 and p70S6K	0.43
MAPK Family Pathway	0.60	SOCS Pathway	0.29
JAK-STAT Pathway	0.57

Immune response IL-12-induced IFN-gamma production

	Immune response IL-12-induced IFN-gamma production	1.00			IL12-mediated signaling events	0.33
	Immune response_IL-12-induced IFN-gamma production	0.88

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Allograft rejection

	Allograft rejection	1.00			THC Differentiation Pathway	0.39
	Type I diabetes mellitus	0.67

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for IL12B

	Immune response IL-23 signaling pathway
	Immune response IL-12-induced IFN-gamma production
	Immune response IL-22 signaling pathway
	Immune response IL-12 signaling pathway

3 R&D Systems Pathways for IL12B

	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
	Th1 Differentiation
	Th17 Differentiation

5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL12B (see all 28)

	THC Differentiation Pathway
	MSP-RON Signaling
	TRAF Pathway
	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer

5/6 GeneGo (Thomson Reuters) Pathways for IL12B (see all 6)

	Immune response IL-12 signaling pathway
	Immune response IL-22 signaling pathway
	Cytokine production by Th17 cells in CF (Mouse model)
	Immune response IL-12-induced IFN-gamma production
	Cytokine production by Th17 cells in CF

5 BioSystems Pathways for IL12B

	Cytokines and Inflammatory Response
	Toll-like receptor signaling pathway
	IL27-mediated signaling events
	IL12-mediated signaling events
	IL23-mediated signaling events

5/15 Kegg Pathways (Kegg details for IL12B) (see all 15):

	Cytokine-cytokine receptor interaction
	Toll-like receptor signaling pathway
	RIG-I-like receptor signaling pathway
	Jak-STAT signaling pathway
	Type I diabetes mellitus

IL12B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL12B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/57 Interacting proteins for IL12B (P29460^{1, 3} ENSP00000231228⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 57)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL12A	P29459¹^,³, ENSP00000303231⁴	EBI-1029614,EBI-1029636 I2D: score=5 STRING: ENSP00000303231
IL12RB1	P42701³, ENSP00000314425⁴	I2D: score=3 STRING: ENSP00000314425
IL23R	Q5VWK5³, ENSP00000321345⁴	I2D: score=1 STRING: ENSP00000321345
IRF5	Q13568³, ENSP00000349770⁴	I2D: score=1 STRING: ENSP00000349770
IL23A	Q9NPF7³, ENSP00000228534⁴	I2D: score=5 STRING: ENSP00000228534

About this table

Gene Ontology (GO): 5/52 biological process terms (GO ID links to tree view) (see all 52): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001916	positive regulation of T cell mediated cytotoxicity	ISS	--
GO:0002230	positive regulation of defense response to virus by host	ISS	--
GO:0002827	positive regulation of T-helper 1 type immune response	ISS	--
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IDA	7903063
GO:0002862	negative regulation of inflammatory response to antigenic stimulus	IEA	--

IL12B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL12B for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL12B

2 DrugBank Compounds for IL12B About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
5-Mercapto-2-Nitro-Benzoic Acid	--	15139-21-6	target	--	17139284 17016423
Alpha-D-Mannose	--	3458-28-4	target	--	17139284 17016423

10/28 Novoseek chemical compound relationships for IL12B gene (see all 28) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
il-12	88.4	11	10525320 (1), 20350312 (1), 15860229 (1), 16754651 (1) (see all 9)
il 10	49	4	16519741 (3), 17653830 (1)
rantes	46.4	7	10570261 (2), 16388854 (1), 19220953 (1), 15182255 (1) (see all 5)
lipoteichoic acid	41.2	4	17567674 (2), 8675286 (1), 15146415 (1)
sb 203580	33.9	8	12603851 (1), 10570261 (1), 12704121 (1), 12847227 (1) (see all 5)
poly(i-c)	26.9	2	12845500 (1)
polyinosinic-polycytidylic acid	24.6	1	12845500 (1)
imiquimod	16.7	2	10480263 (1), 10607486 (1)
ccl4	15.1	1	15182255 (1)
pd 98,059	13.9	4	12603851 (1), 12704121 (1)

Search CenterWatch for drugs/clinical trials and news about IL12B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL12B gene:

NM_002187.2

Unigene Cluster for IL12B:

Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

Hs.674 [show with all ESTs]

Unigene Representative Sequence: NM_002187

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000231228(uc003lxr.1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL12B
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate IL12B (see all 12):
		hsa-miR-130a* hsa-miR-3660 hsa-miR-589* hsa-miR-548e hsa-miR-23c hsa-miR-520a-5p hsa-miR-548a-3p hsa-miR-23b

		SwitchGear 3'UTR luciferase reporter plasmid: IL12B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL12B (see all 7) OriGene shRNA RFP: IL12B OriGene siRNA: IL12B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL12B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL12B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL12B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL12B (NM_002187)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL12B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL12B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL12B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL12B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL12B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL12B

Additional cDNA sequence:

AF180563.1 AY046592.1 AY046593.1 BC067498.1 BC067499.1 BC067500.1 BC067501.1 BC067502.1

BC074723.2 EF173865.1 M65272.1 M65290.1

1 DOTS entry:

DT.303521

22 AceView cDNA sequences:

BC074723 M65272 BC067502 BC067499 AF180563 BC067501 AY046593 BC067500

NM_002187 CD559449 CD559607 CD559605 CD559453 BC067498 M65290 CD559448

CD559450 CD559451 CD559602 CK130264 CD559603 CD559604

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL12B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See IL12B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL12B

SOURCE GeneReport for Unigene cluster: Hs.674

SABiosciences Expression via Pathway-Focused PCR Arrays including IL12B (see all 20):

HIV Host Response in human mouse rat

Antiviral Response in human mouse rat

Interferons & Receptors in human mouse rat

Inflammasomes in human mouse rat

T-cell & B-cell Activation in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL12B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL12B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL12B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL12B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL12B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL12B gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Il12b^{1 , 5}	interleukin 12b^{1, 5}	75.47(n)¹ 69.57(a)¹		11 (25.94 cM)⁵ 16160¹ NM_008352.2¹ NP_032378.1¹ 44400063⁵
chicken (Gallus gallus)	Aves	IL12B¹	interleukin 12B (natural killer cell stimulatory factor more	56.28(n) 46.89(a)		404671 NM_213571.1 NP_998736.1
lizard (Anolis carolinensis)	Reptilia	IL12B⁶	--	30(a)	1 ↔ 1	2(121596595-121601978)
zebrafish (Danio rerio)	Actinopterygii	il12ba¹	interleukin 12Ba	46.42(n) 34.44(a)		445373 NM_001007108.1 NP_001007109.1

ENSEMBL Gene Tree for IL12B (if available)
TreeFam Gene Tree for IL12B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10476289^1,2	H,	--	153835931(+)	`GCTTCC/TACCCC`	1	--	ds500¹		4		NS EA	420
rs56409614^1,2	C,	--	153836614(+)	`GACAGG/TGTCTC`	1	--	ut3¹		2		CSA WA	119
rs41292468^1,2	C	--	153836751(-)	`ATTAGC/TCAGGC`	1	--	ut3¹		0	--	--	--	--
rs3213114^1,2	C,H,	--	153836977(-)	`GGAAAC/TCTGAC`	1	--	ut3¹		7		NS EA WA	620
rs3213113^1,2	C,F,H,	--	153837272(-)	`TTGCCA/CTGGGC`	1	--	ut3¹		14		NS MN EA NA WA	1082
rs1805132^1,2	C	--	153837309(-)	`ATCAGC/ATAATT`	1	--	ut3¹		5		MN	408
rs77141237^1,2	C,	--	153837621(+)	`AGGCCC/TTCCTT`	1	--	int¹		0	--	--	--	--
rs55904475^1,2	C,	--	153837904(+)	`GTCCTA/GCATAA`	1	--	int¹		0	--	--	--	--
rs11574791^1,2	C,H	--	153838058(-)	`GGCCAG/CCCCAG`	1	--	int¹		10		NA MN NS EA	802
rs11574789^1,2	C,H	--	153838281(-)	`TTGCAG/AAAACA`	1	--	int¹		10		NA MN NS EA	844

HapMap Linkage Disequilibrium report for IL12B (158741791 - 158757895 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IL12B: --
Human Gene Mutation Database (HGMD): IL12B

Locus Specific Mutation Databases (LSDB): IL12B

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL12B

DNA2.0 Custom Variant and Variant Library Synthesis for IL12B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL12B for disorders           About GeneDecksing

OMIM gene information: 161561
OMIM disorders: 209950  600807
UniProtKB/Swiss-Prot: IL12B_HUMAN, P29460

Defects in IL12B are a cause of Mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also

known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness

caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental

non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause

severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of

Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the

impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of

overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in

life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease

with autosomal recessive, autosomal dominant or X-linked inheritance

Genetic variations in IL12B are a cause of susceptibility to psoriasis type 11 (PSORS11) [MIM:612599].

Psoriasis is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by

red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte

proliferation and infiltration of inflammatory cells into the dermis and epidermis

20/143 diseases for IL12B (see all 143): About MalaCards

bcg and salmonella infection, disseminated bcg and salmonella infection multiple sclerosis asthma

diffuse large b-cell lymphoma subacute sclerosing panencephalitis mycobacterial infection polymyalgia rheumatica

b-cell lymphomas plasmodium falciparum malaria lepromatous leprosy non-hodgkin lymphoma

severe acute respiratory syndrome lupus erythematosus type 1 diabetes mellitus paratyphoid fever

inflammatory bowel disease typhoid fever myasthenia gravis carotid stenosis

10/51 Novoseek disease relationships for IL12B gene (see all 51) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mycobacterial infection	55.9	3	9722917 (1), 12595896 (1), 17445208 (1)
necrosis	55.7	34	9856837 (2), 8698475 (1), 12603851 (1), 17727629 (1) (see all 31)
psoriasis	53.4	20	15102082 (3), 12413772 (1), 18800148 (1), 20476959 (1) (see all 14)
multiple sclerosis	40.5	5	15579375 (1), 11110796 (1), 12325088 (1), 18082575 (1) (see all 5)
autoimmune diseases	37.6	2	15993716 (1), 18587636 (1)
hypersensitivity contact	35.6	2	9605132 (2)
malaria cerebral	33.3	7	12424623 (2), 20003322 (2), 14573655 (1), 15175646 (1)
tumors	31.9	31	9856837 (2), 8698475 (1), 12603851 (1), 19330264 (1) (see all 28)
tuberculosis	31.4	8	16367946 (1), 18522869 (1), 17392024 (1), 14551880 (1) (see all 8)
inflammatory bowel diseases	30.1	4	11515847 (2), 19817673 (1), 18082575 (1)

Genatlas disease: IL12B

susceptibility to BCG,non tuberculous mycobacterial and salmonella infections,with the presence of mature granulomas

and a secundary impairment of IFNG production

Genetic Association Database (GAD): IL12B
Human Genome Epidemiology (HuGE) Navigator: IL12B (190 documents)

Export disorders for IL12B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IL12B gene, integrated from 9 sources (see all 641):
(articles sorted by number of sources associating them with IL12B)

Utopia: connect your pdf to the dynamic
world of online information

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. (PubMed id 1673147)^{1, 2, 3, 9} Wolf S.F....Perussia B. (1991)
Lack of association between IL-12B gene polymorphism and autoimmune thyroid disease in Japanese patients. (PubMed id 15644581)^{1, 4, 9} Ikeda Y....Hashimoto K. (2004)
Interleukin 12 (IL12B), interleukin 12 receptor (IL12RB1) and interleukin 23 (IL23A) gene polymorphism in systemic lupus erythematosus. (PubMed id 15941730)^{1, 4, 9} Sanchez E....Martin J. (2005)
Associations between IL12B polymorphisms and tuberculosis in the Hong Kong Chinese population. (PubMed id 15295696)^{1, 4, 9} Tso H.W....Chiang A.K. (2004)
Interleukin 12 (IL12B) and interleukin 12 receptor (IL12RB1) gene polymorphisms in rheumatoid arthritis. (PubMed id 15993716)^{1, 4, 9} Orozco G....Martin J. (2005)
Polymorphisms in the IL-12B gene and outcome of HCV infection. (PubMed id 15871664)^{1, 4, 9} Houldsworth A....Cramp M.E. (2005)
Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infection. (PubMed id 15464247)^{1, 4, 9} Mueller T....Berg T. (2004)
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. (PubMed id 1674604)^{1, 2, 9} Gubler U....Gately M.K. (1991)
The IL12B gene is associated with asthma. (PubMed id 15322986)^{1, 4, 9} Randolph A.G....Weiss S.T. (2004)
Associations of the IL12B promoter polymorphism in longitudinal data from asthmatic patients 7 to 42 years of age. (PubMed id 15007350)^{1, 4, 9} Khoo S.K....Le Souef P. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3593	HGNC: 5970	AceView: IL12B	Ensembl:ENSG00000113302	euGenes: HUgn3593
ECgene: IL12B	Kegg: 3593	H-InvDB: IL12B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IL12B	Pharmacogenomics, SNPs, Pathways
IL12Bbase	http://bioinf.uta.fi/IL12Bbase/
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/IL12B
SeattleSNPs	http://pga.gs.washington.edu/data/il12b/

Intellectual Property for IL12B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IL12B gene:
Search GeneIP for patents involving IL12B

GeneCards and IP:
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IL12B Gene

interleukin 12B (natural killer cell stimulatory factor...

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