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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL12A Gene

protein-coding   GIFtS: 62
GCID: GC03P159706

Interleukin 12A (Natural Killer Cell Stimulatory Factor...


(Previous symbol: NKSF1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 12A (Natural Killer Cell Stimulatory Factor 1, Cytotoxic
Lymphocyte Maturation Factor 1, P35)1 2
     Interleukin 121
NKSF11 2 3     Natural Killer Cell Stimulatory Factor 11
IL35 Subunit1 2     p351
Interleukin-12 Alpha Chain1 2     Subunit P351
NF Cell Stimulatory Factor Chain 11 2     CLMF2
Cytotoxic Lymphocyte Maturation Factor 35 KDa Subunit2 3     NFSK2
IL-12A2 3     P352
CLMF P352 3     Cytotoxic Lymphocyte Maturation Factor 1, P352
IL-12 Subunit P352 3     IL-12, Subunit P352
NK Cell Stimulatory Factor Chain 12 3     Interleukin 12, P352
35 KD Subunit1     Interleukin-12 Subunit Alpha2
IL-121     Natural Killer Cell Stimulatory Factor 1, 35 KD Subunit2
Cytotoxic Lymphocyte Maturation Factor 11     

External Ids:    HGNC: 59691   Entrez Gene: 35922   Ensembl: ENSG000001688117   OMIM: 1615605   UniProtKB: P294593   

Export aliases for IL12A gene to outside databases

Previous GC identifers: GC03P156994 GC03P160653 GC03P160988 GC03P161027 GC03P161189 GC03P157103


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL12A Gene:
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of
biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by
this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for
the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1
and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription
protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this
cytokine in innate immunity. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL12A Gene: 
IL12A (interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)) is a protein-coding gene. Diseases associated with IL12A include classic kaposi sarcoma, and granulomatous gastritis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Type I diabetes mellitus. GO annotations related to this gene include cytokine activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot: IL12A_HUMAN, P29459
Function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of
NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC

Gene Wiki entry for IL12A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL12A gene promoter:
         GCNF   MEF-2   NF-kappaB   Ik-3   MEF-2A   GCNF-1   aMEF-2   GCNF-2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL12A promoter sequence
   Search SABiosciences Chromatin IP Primers for IL12A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL12A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.33   Ensembl cytogenetic band:  3q25.33   HGNC cytogenetic band: 3q25.33

IL12A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL12A gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P159706:  view genomic region     (about GC identifiers)

Start:
159,706,537 bp from pter      End:
159,713,806 bp from pter
Size:
7,270 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL12A_HUMAN, P29459 (See protein sequence)
Recommended Name: Interleukin-12 subunit alpha precursor  
Size: 219 amino acids; 24874 Da
Subunit: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12
Subcellular location: Secreted
Sequence caution: Sequence=AAA59937.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for IL12A:
1F45 (3D)        3HMX (3D)    
Secondary accessions: Q96QZ1

Explore the universe of human proteins at neXtProt for IL12A: NX_P29459

Explore proteomics data for IL12A at MOPED 

IL12A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IL12A Protein Expression

REFSEQ proteins: NP_000873.2  
ENSEMBL proteins: 
 ENSP00000303231   ENSP00000420184   ENSP00000419046  

Human Recombinant Protein Products for IL12A: 
EMD Millipore Purified and/or Recombinant IL12A Protein
R&D Systems Recombinant & Natural Proteins for IL12A (IL-12)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
Browse OriGene Protein Over-expression Lysates
OriGene Custom MassSpec 
OriGene Custom Protein Services for IL12A
GenScript Purified and Recombinant Proteins for IL12A
Novus Biologicals IL12A Proteins
Novus Biologicals IL12A Lysates
Sino Biological Recombinant Protein for IL12A
Sino Biological Cell Lysate for IL12A 
ProSpec Recombinant Protein for IL12A
Cloud-Clone Corp. Proteins for IL12A 

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space IDA16456693
GO:0005737cytoplasm IEA--
GO:0043514interleukin-12 complex NAS14718574

IL12A for ontologies           About GeneDecksing



IL12A Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of IL12A
R&D Systems Antibodies for IL12A (IL-12, IL-12 p70, IL-12/IL-35 p35)
OriGene Antibodies for IL12A
OriGene Custom Antibody Services for IL12A
GenScript Custom Superior Antibodies Services for IL12A
Novus Biologicals IL12A Antibodies
Abcam antibodies for IL12A
Cloud-Clone Corp. Antibodies for IL12A 
ThermoFisher Antibody for IL12A
LSBio Antibodies in human, mouse, rat for IL12A 

Assay Products for IL12A: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for IL12A
R&D Systems ELISAs for IL12A (IL-12, IL-12 p70)         (see all)
GenScript Custom Assay Services for IL12A
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for IL12A 
Cloud-Clone Corp. CLIAs for IL12A


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IL: Interleukins and interleukin receptors

3 InterPro protein domains:
 IPR012351 4_helix_cytokine_core
 IPR009079 4_helix_cytokine-like_core
 IPR004281 IL12

Graphical View of Domain Structure for InterPro Entry P29459

ProtoNet protein and cluster: P29459

1 Blocks protein domain: IPB004281 Interleukin-12 alpha subunit

UniProtKB/Swiss-Prot: IL12A_HUMAN, P29459
Similarity: Belongs to the IL-6 superfamily


IL12A for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: IL12A_HUMAN, P29459
Function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of
NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC
Induction: Down-regulated in response to enterovirus 71 (EV71) infection

     Genatlas biochemistry entry for IL12A:
interleukin 12,alpha polypeptide (35kDa),dimerizing with IL12B,secreted by macrophages and dendritic
cells,stimulating IFNG production

     Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125contributes to cytokine activity TAS1673147
GO:0005143interleukin-12 receptor binding NAS1674604
GO:0005515protein binding IPI10899108
GO:0008083contributes to growth factor activity NAS1673147
GO:0042163interleukin-12 beta subunit binding IEA--
     
IL12A for ontologies           About GeneDecksing


Phenotypes:
     5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Il12a):
 homeostasis/metabolism  immune system  mortality/aging  respiratory system  tumorigenesis 

IL12A for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for IL12A: Il12atm1Jm Il12atm1Cab

   inGenious Targeting Laboratory - Custom generated mouse model solutions for IL12A 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL12A

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL12A 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL12A 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL12A
4 QIAGEN miScript miRNA Assays for microRNAs that regulate IL12A:
hsa-miR-607 hsa-miR-590-5p hsa-miR-340 hsa-miR-21
SwitchGear 3'UTR luciferase reporter plasmidIL12A 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL12A
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL12A

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IL12A
Sirion Biotech Customized adenovirus for overexpression of IL12A

Clone
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Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for IL12A (see all 12)
OriGene ORF clones in mouse, rat for IL12A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL12A (NM_000882)
Sino Biological Human cDNA Clone for IL12A
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL12A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL12A
Sirion Biotech Customized lentivirus for stable overexpression of IL12A 
                     Customized lentivirus expression plasmids for stable overexpression of IL12A 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IL12A
Search LifeMap BioReagents cell lines for IL12A
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL12A


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IL12A About   (see all 25)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation0.94
NFAT Signaling and Lymphocyte Interactions0.57
MIF Regulation of Innate Immune Cells0.94
PGC1Alpha Pathway0.51
PEDF Induced Signaling0.73
STAT3 Pathway0.47
all-trans-Retinoic Acid Signaling in Brain0.71
Endothelin-1 Signaling Pathway0.46
2Allograft rejection
Allograft rejection0.69
THC Differentiation Pathway0.37
Type I diabetes mellitus0.69
3Toll-like receptor signaling pathway
Toll-like receptor signaling pathway0.93
Chagas disease (American trypanosomiasis)0.33
Toll-like receptor signaling pathway0.93
4IL27-mediated signaling events
IL27-mediated signaling events0.38
Th1 Differentiation0.38
5Immune response IL-12-induced IFN-gamma production
Immune response IL-12-induced IFN-gamma production0.88
IL12-mediated signaling events0.33

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

3 EMD Millipore Pathways for IL12A
    Immune response IL-12-induced IFN-gamma production
Immune response IL-22 signaling pathway
Immune response IL-12 signaling pathway

2 R&D Systems Pathways for IL12A
    Th1 Differentiation
IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL12A (see all 28)
    THC Differentiation Pathway
MSP-RON Signaling
TRAF Pathway
Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer

3 GeneGo (Thomson Reuters) Pathways for IL12A
    Immune response IL-12 signaling pathway
Immune response IL-22 signaling pathway
Immune response IL-12-induced IFN-gamma production

3 BioSystems Pathways for IL12A
    Toll-like receptor signaling pathway
IL12-mediated signaling events
IL27-mediated signaling events



5/19         Kegg Pathways  (Kegg details for IL12A) (see all 19):
    Cytokine-cytokine receptor interaction
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Jak-STAT signaling pathway
Type I diabetes mellitus


IL12A for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL12A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/42 Interacting proteins for IL12A (P294591, 3 ENSP000003032314) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
InteractantInteraction Details
GeneCardExternal ID(s)
IL12BP294601, 3, ENSP000002312284EBI-1029636,EBI-1029614 I2D: score=5 STRING: ENSP00000231228
EBI3Q142133, ENSP000002218474I2D: score=4 STRING: ENSP00000221847
CD28P107473, ENSP000003248904I2D: score=1 STRING: ENSP00000324890
IL12RB1P427013, ENSP000003144254I2D: score=1 STRING: ENSP00000314425
IL8P101453, ENSP000003065124I2D: score=1 STRING: ENSP00000306512
About this table

Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001916positive regulation of T cell mediated cytotoxicity IDA1674604
GO:0002860positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IDA7903063
GO:0006955immune response TAS9789052
GO:0007050cell cycle arrest IDA16942485
GO:0009615response to virus IEP16548883

IL12A for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL12A for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL12A

1 PharmGKB related drug/compound annotation for IL12A gene    About this table
Drug/compound PharmGKB Annotation
mycophenolate mofetilCA  

Search CenterWatch for drugs/clinical trials and news about IL12A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL12A gene: 
NM_000882.3  

Unigene Cluster for IL12A:

Interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
Hs.673  [show with all ESTs]
Unigene Representative Sequence: BC035571
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000305579(uc003fcx.3) ENST00000480088 ENST00000468862 ENST00000496308
ENST00000480787 ENST00000466512
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL12A
4 QIAGEN miScript miRNA Assays for microRNAs that regulate IL12A:
hsa-miR-607 hsa-miR-590-5p hsa-miR-340 hsa-miR-21
SwitchGear 3'UTR luciferase reporter plasmidIL12A 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL12A
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL12A
Clone
Products:
     
OriGene clones in human, mouse for IL12A (see all 12)
OriGene ORF clones in mouse, rat for IL12A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL12A (NM_000882)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL12A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL12A
Sirion Biotech Customized lentivirus for stable overexpression of IL12A 
                     Customized lentivirus expression plasmids for stable overexpression of IL12A 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for IL12A
OriGene qSTAR qPCR primer pairs in human, mouse for IL12A
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL12A
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL12A
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL12A

Additional mRNA sequence: 

AF101062.1 AF180562.1 BC035571.1 BC104982.1 BC104984.1 M65271.1 M65291.1 

3 DOTS entries:

DT.203502  DT.101981213  DT.101981212 

18 AceView cDNA sequences:

NM_000882 CD013915 AF180562 AF101062 AI803560 BC035571 BI824638 BG702253 
CD013916 BI523569 M65271 AI332701 AI304577 CD013914 M65291 AU099435 
AU105695 AW472810 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for IL12A    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:                          -                                 
SP2:                          -                                 
SP3:                          -     -                           
SP4:                    -     -                                 
SP5:                                                            


ECgene alternative splicing isoforms for IL12A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL12A expression in normal human tissues (normalized intensities)      IL12A embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAAGCATCTG
IL12A Expression
About this image


IL12A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Ovary (Reproductive System)
         Human Ovarian Fibroblasts (HOF)   
 
 Adipose (Muscoskeletal System)
         Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
 
 Fibroblast (Uncategorized)
         Human Ovarian Fibroblasts (HOF)   

See IL12A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL12A

SOURCE GeneReport for Unigene cluster: Hs.673
    SABiosciences Expression via Pathway-Focused PCR Arrays including IL12A (see all 14): 
          Growth Factors in human mouse rat
          Antiviral Response in human mouse rat
          Angiogenic Growth Factors in human mouse rat
          Leukemia in human mouse rat
          Toll-Like Receptor Signaling Pathway in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for IL12A
OriGene qSTAR qPCR primer pairs in human, mouse for IL12A
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL12A
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL12A
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL12A
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL12A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL12A gene from 2/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il12a1 , 5 interleukin 12a1, 5 70.91(n)1
59.65(a)1
  3 (31.92 cM)5
161591  NM_001159424.11  NP_001152896.11 
 686906445 
chicken
(Gallus gallus)
Aves IL12A6
interleukin 12A (natural killer cell stimulatory f...
33(a)
1 ↔ 1
9(21727352-21729152)


ENSEMBL Gene Tree for IL12A (if available)
TreeFam Gene Tree for IL12A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/240 SNPs in IL12A are shown (see all 240)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs113975221,2
C--157102126(+) GACCCC/-TGGAT 1 -- us2k11Minor allele frequency- -:0.00NA 2
rs1487362291,2
--159685421(+) AAATCA/GGCTGA 1 -- us2k10--------
rs597193861,2
C,F--159685434(+) TTTTTT/AAAGTT 1 -- us2k13Minor allele frequency- A:0.15WA 122
rs1457200411,2
C--159685496(+) ATTAA-/TTTTTT 1 -- us2k10--------
rs117183771,2
C,F,H--159685512(+) TTTTGC/Tatatc 1 -- us2k11Minor allele frequency- T:0.50NA 2
rs1834027871,2
--159685528(+) TAAAAA/TGTGAC 1 -- us2k10--------
rs749818451,2
--159685589(+) CCTTAC/TAGCAT 1 -- us2k10--------
rs786644421,2
C,F--159685599(+) TTGGCC/TGAGAC 1 -- us2k11Minor allele frequency- T:0.03NA 120
rs1871516761,2
--159685600(+) TGGCCA/GAGACC 1 -- us2k10--------
rs1415205311,2
--159685673(+) AATCAC/TGTATT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for IL12A (159706537 - 159713806 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for IL12A:    About this table     
Variant IDTypeSubtypePubMed ID
nsv829769CNV Gain17160897


Human Gene Mutation Database (HGMD): IL12A
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing IL12A
DNA2.0 Custom Variant and Variant Library Synthesis for IL12A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 161560    OMIM disorders: --

20/108 diseases for IL12A (see all 108):    About MalaCards
classic kaposi sarcoma    granulomatous gastritis    aphthous stomatitis    coccidioidomycosis
west nile encephalitis    stomatitis    takayasu's arteritis    polymyalgia rheumatica
carotid stenosis    h. pylori infection    rubella    cerebral malaria
esophageal adenocarcinoma    cutaneous malignant melanoma    pemphigus vulgaris    primary biliary cirrhosis
interstitial lung disease    trypanosomiasis    kaposi's sarcoma    pemphigus


IL12A for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
Genetic Association Database (GAD): IL12A
Human Genome Epidemiology (HuGE) Navigator: IL12A (121 documents)

Export disorders for IL12A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IL12A gene, integrated from 9 sources (see all 287):
(articles sorted by number of sources associating them with IL12A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. (PubMed id 1673147)1, 2, 3 Wolf S.F....Perussia B. (1991)
  2. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. (PubMed id 19458352)1, 4, 9 Hirschfield G.M....Siminovitch K.A. (2009)
  3. Association of single nucleotide polymorphisms in the IL-12 (IL-12A and B) and IL-12 receptor (IL-12Rbeta1 and beta2) genes and gene -gene interactions with atopic dermatitis in Koreans. (PubMed id 20060272)1, 4, 9 Namkung J.H....Yang J.M. (2010)
  4. Interactions of IL-12A and IL-12B polymorphisms on the risk of cervical cancer in Chinese women. (PubMed id 19118071)1, 4, 9 Chen X....Hu Z. (2009)
  5. Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes. (PubMed id 17152005)1, 4, 9 Dhiman N....Jacobson R.M. (2007)
  6. Genome-wide association study identifies 12 new susce ptibility loci for primary biliary cirrhosis. (PubMed id 21399635)1, 4 Mells G.F....Anderson C.A. (2011)
  7. Immunogenetic characteristics of patients with autoim mune gastritis. (PubMed id 20082482)1, 4 Oksanen A.M....Partanen J.A. (2010)
  8. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (2010)
  9. Cytokine gene polymorphisms in sarcoidosis. (PubMed id 21086908)1, 4 Vasakova M....Striz I. (2010)
  10. Genome-wide meta-analyses identify three loci associa ted with primary biliary cirrhosis. (PubMed id 20639880)1, 4 Liu X....Seldin M.F. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3592 HGNC: 5969 AceView: IL12A Ensembl:ENSG00000168811 euGenes: HUgn3592
ECgene: IL12A Kegg: 3592 H-InvDB: IL12A

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IL12A Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL12A Genetics and Cytogenetics in Oncology and Haematology
Wikipedia http://en.wikipedia.org/wiki/Interleukin_12
SeattleSNPshttp://pga.gs.washington.edu/data/il12a/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for IL12A gene:
Search GeneIP for patents involving IL12A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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