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Aliases for IL12A Gene

Aliases for IL12A Gene

  • Interleukin 12A 2 3
  • Interleukin 12A (Natural Killer Cell Stimulatory Factor 1, Cytotoxic Lymphocyte Maturation Factor 1, P35) 2 3
  • Cytotoxic Lymphocyte Maturation Factor 35 KDa Subunit 3 4
  • NF Cell Stimulatory Factor Chain 1 2 3
  • NK Cell Stimulatory Factor Chain 1 3 4
  • Interleukin-12 Alpha Chain 2 3
  • IL35 Subunit 2 3
  • CLMF P35 3 4
  • IL-12A 3 4
  • NKSF1 3 4
  • P35 2 3
  • Cytotoxic Lymphocyte Maturation Factor 1, P35 3
  • Natural Killer Cell Stimulatory Factor 1 2
  • Cytotoxic Lymphocyte Maturation Factor 1 2
  • Interleukin-12 Subunit Alpha 3
  • Interleukin 12, P35 3
  • IL-12, Subunit P35 3
  • IL-12 Subunit P35 4
  • Interleukin 12 2
  • 35 KD Subunit 2
  • Subunit P35 2
  • IL-12 2
  • CLMF 3
  • NFSK 3

External Ids for IL12A Gene

Previous HGNC Symbols for IL12A Gene

  • NKSF1

Previous GeneCards Identifiers for IL12A Gene

  • GC03P156994
  • GC03P160653
  • GC03P160988
  • GC03P161027
  • GC03P161189
  • GC03P159706
  • GC03P157103

Summaries for IL12A Gene

Entrez Gene Summary for IL12A Gene

  • This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL12A Gene

IL12A (Interleukin 12A) is a Protein Coding gene. Diseases associated with IL12A include primary biliary cirrhosis and aphthous stomatitis. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include protein heterodimerization activity and growth factor activity.

UniProtKB/Swiss-Prot for IL12A Gene

  • Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC

Gene Wiki entry for IL12A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL12A Gene

Genomics for IL12A Gene

Regulatory Elements for IL12A Gene

Genomic Location for IL12A Gene

Start:
159,988,750 bp from pter
End:
159,996,019 bp from pter
Size:
7,270 bases
Orientation:
Plus strand

Genomic View for IL12A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL12A Gene

Proteins for IL12A Gene

  • Protein details for IL12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29459-IL12A_HUMAN
    Recommended name:
    Interleukin-12 subunit alpha
    Protein Accession:
    P29459
    Secondary Accessions:
    • Q96QZ1

    Protein attributes for IL12A Gene

    Size:
    219 amino acids
    Molecular mass:
    24874 Da
    Quaternary structure:
    • Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.
    SequenceCaution:
    • Sequence=AAA59937.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL12A Gene

neXtProt entry for IL12A Gene

Proteomics data for IL12A Gene at MOPED

Post-translational modifications for IL12A Gene

  • Glycosylation at Asn93 and Asn107
  • Modification sites at PhosphoSitePlus

Other Protein References for IL12A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL12A Gene

Domains for IL12A Gene

Gene Families for IL12A Gene

HGNC:
  • IL :Interleukins and interleukin receptors

Protein Domains for IL12A Gene

Graphical View of Domain Structure for InterPro Entry

P29459

UniProtKB/Swiss-Prot:

IL12A_HUMAN :
  • P29459
Family:
  • Belongs to the IL-6 superfamily.
genes like me logo Genes that share domains with IL12A: view

Function for IL12A Gene

Molecular function for IL12A Gene

GENATLAS Biochemistry: interleukin 12,alpha polypeptide (35kDa),dimerizing with IL12B,secreted by macrophages and dendritic cells,stimulating IFNG production
UniProtKB/Swiss-Prot Function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC
UniProtKB/Swiss-Prot Induction: Down-regulated in response to enterovirus 71 (EV71) infection.

Gene Ontology (GO) - Molecular Function for IL12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 contributes_to cytokine activity TAS 1673147
GO:0005143 interleukin-12 receptor binding NAS 1674604
GO:0005515 protein binding IPI 10899108
GO:0008083 contributes_to growth factor activity NAS 1673147
GO:0042163 interleukin-12 beta subunit binding IPI 11023671
genes like me logo Genes that share ontologies with IL12A: view
genes like me logo Genes that share phenotypes with IL12A: view

Animal Models for IL12A Gene

MGI Knock Outs for IL12A:

miRNA for IL12A Gene

miRTarBase miRNAs that target IL12A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IL12A Gene

Localization for IL12A Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL12A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL12A Gene COMPARTMENTS Subcellular localization image for IL12A gene
Compartment Confidence
extracellular 5
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IL12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IDA 16456693
GO:0005737 cytoplasm IEA --
GO:0043514 interleukin-12 complex NAS 14718574
genes like me logo Genes that share ontologies with IL12A: view

Pathways for IL12A Gene

genes like me logo Genes that share pathways with IL12A: view

Gene Ontology (GO) - Biological Process for IL12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity IDA 1674604
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IDA 7903063
GO:0006955 immune response TAS 9789052
GO:0007050 cell cycle arrest IDA 16942485
GO:0009615 response to virus IEP 16548883
genes like me logo Genes that share ontologies with IL12A: view

Compounds for IL12A Gene

(1) PharmGKB related drug/compound annotations for IL12A Gene

Drug/compound Annotation
mycophenolate mofetil CA
genes like me logo Genes that share compounds with IL12A: view

Transcripts for IL12A Gene

mRNA/cDNA for IL12A Gene

(18) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL12A Gene

Interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL12A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5:

Relevant External Links for IL12A Gene

GeneLoc Exon Structure for
IL12A
ECgene alternative splicing isoforms for
IL12A

Expression for IL12A Gene

mRNA expression in normal human tissues for IL12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL12A Gene

This gene is overexpressed in Esophagus - Mucosa (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL12A Gene

SOURCE GeneReport for Unigene cluster for IL12A Gene Hs.673

genes like me logo Genes that share expressions with IL12A: view

No data available for mRNA Expression by UniProt/SwissProt for IL12A Gene

Orthologs for IL12A Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL12A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL12A 35
  • 99.47 (n)
  • 99.6 (a)
IL12A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL12A 35
  • 87.48 (n)
  • 83.25 (a)
IL12A 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL12A 35
  • 87.98 (n)
  • 84.93 (a)
IL12A 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il12a 35
  • 70.76 (n)
  • 59.65 (a)
Il12a 16
Il12a 36
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL12A 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL12A 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il12a 35
  • 72.09 (n)
  • 60 (a)
chicken
(Gallus gallus)
Aves IL12A 36
  • 35 (a)
OneToOne
Species with no ortholog for IL12A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL12A Gene

ENSEMBL:
Gene Tree for IL12A (if available)
TreeFam:
Gene Tree for IL12A (if available)

Paralogs for IL12A Gene

No data available for Paralogs for IL12A Gene

Variants for IL12A Gene

Structural Variations from Database of Genomic Variants (DGV) for IL12A Gene

Variant ID Type Subtype PubMed ID
nsv829769 CNV Gain 17160897

Relevant External Links for IL12A Gene

HapMap Linkage Disequilibrium report
IL12A
Human Gene Mutation Database (HGMD)
IL12A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for IL12A Gene

Disorders for IL12A Gene

Relevant External Links for IL12A

Genetic Association Database (GAD)
IL12A
Human Genome Epidemiology (HuGE) Navigator
IL12A
genes like me logo Genes that share disorders with IL12A: view

No data available for UniProtKB/Swiss-Prot for IL12A Gene

Publications for IL12A Gene

  1. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. (PMID: 1673147) Wolf S.F. … Perussia B. (J. Immunol. 1991) 2 3 4
  2. Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes. (PMID: 17152005) Dhiman N. … Jacobson R.M. (J. Infect. Dis. 2007) 3 23 48
  3. Interactions of IL-12A and IL-12B polymorphisms on the risk of cervical cancer in Chinese women. (PMID: 19118071) Chen X. … Hu Z. (Clin. Cancer Res. 2009) 3 23 48
  4. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. (PMID: 19458352) Hirschfield G.M. … Siminovitch K.A. (N. Engl. J. Med. 2009) 3 23 48
  5. Association of single nucleotide polymorphisms in the IL-12 (IL-12A and B) and IL-12 receptor (IL-12Rbeta1 and beta2) genes and gene-gene interactions with atopic dermatitis in Koreans. (PMID: 20060272) Namkung J.H. … Yang J.M. (J. Dermatol. Sci. 2010) 3 23 48

Products for IL12A Gene

Sources for IL12A Gene

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