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Aliases for IL12A Gene

Aliases for IL12A Gene

  • Interleukin 12A 2 3 5
  • Interleukin 12A (Natural Killer Cell Stimulatory Factor 1, Cytotoxic Lymphocyte Maturation Factor 1, P35) 2 3
  • Cytotoxic Lymphocyte Maturation Factor 35 KDa Subunit 3 4
  • NF Cell Stimulatory Factor Chain 1 2 3
  • NK Cell Stimulatory Factor Chain 1 3 4
  • Interleukin-12 Alpha Chain 2 3
  • IL35 Subunit 2 3
  • CLMF P35 3 4
  • IL-12A 3 4
  • NKSF1 3 4
  • P35 2 3
  • Cytotoxic Lymphocyte Maturation Factor 1, P35 3
  • Natural Killer Cell Stimulatory Factor 1 2
  • Cytotoxic Lymphocyte Maturation Factor 1 2
  • Interleukin 12, P35 3
  • IL-12, Subunit P35 3
  • IL-12 Subunit P35 4
  • Interleukin 12 2
  • 35 KD Subunit 2
  • Subunit P35 2
  • IL-12 2
  • CLMF 3
  • NFSK 3

External Ids for IL12A Gene

Previous HGNC Symbols for IL12A Gene

  • NKSF1

Previous GeneCards Identifiers for IL12A Gene

  • GC03P156994
  • GC03P160653
  • GC03P160988
  • GC03P161027
  • GC03P161189
  • GC03P159706
  • GC03P157103

Summaries for IL12A Gene

Entrez Gene Summary for IL12A Gene

  • This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL12A Gene

IL12A (Interleukin 12A) is a Protein Coding gene. Diseases associated with IL12A include primary biliary cirrhosis and intracranial aneurysm. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein heterodimerization activity and growth factor activity.

UniProtKB/Swiss-Prot for IL12A Gene

  • Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.

Gene Wiki entry for IL12A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL12A Gene

Genomics for IL12A Gene

Regulatory Elements for IL12A Gene

Promoters for IL12A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IL12A on UCSC Golden Path with GeneCards custom track

Genomic Location for IL12A Gene

Chromosome:
3
Start:
159,988,750 bp from pter
End:
159,996,019 bp from pter
Size:
7,270 bases
Orientation:
Plus strand

Genomic View for IL12A Gene

Genes around IL12A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL12A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL12A Gene

Proteins for IL12A Gene

  • Protein details for IL12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29459-IL12A_HUMAN
    Recommended name:
    Interleukin-12 subunit alpha
    Protein Accession:
    P29459
    Secondary Accessions:
    • Q96QZ1

    Protein attributes for IL12A Gene

    Size:
    219 amino acids
    Molecular mass:
    24874 Da
    Quaternary structure:
    • Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.
    SequenceCaution:
    • Sequence=AAA59937.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL12A Gene

neXtProt entry for IL12A Gene

Proteomics data for IL12A Gene at MOPED

Post-translational modifications for IL12A Gene

  • Glycosylation at Asn 93 and Asn 107
  • Modification sites at PhosphoSitePlus

Other Protein References for IL12A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IL12A Gene

Domains & Families for IL12A Gene

Gene Families for IL12A Gene

Protein Domains for IL12A Gene

Graphical View of Domain Structure for InterPro Entry

P29459

UniProtKB/Swiss-Prot:

IL12A_HUMAN :
  • Belongs to the IL-6 superfamily.
Family:
  • Belongs to the IL-6 superfamily.
genes like me logo Genes that share domains with IL12A: view

Function for IL12A Gene

Molecular function for IL12A Gene

GENATLAS Biochemistry:
interleukin 12,alpha polypeptide (35kDa),dimerizing with IL12B,secreted by macrophages and dendritic cells,stimulating IFNG production
UniProtKB/Swiss-Prot Function:
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.
UniProtKB/Swiss-Prot Induction:
Down-regulated in response to enterovirus 71 (EV71) infection.
genes like me logo Genes that share phenotypes with IL12A: view

Human Phenotype Ontology for IL12A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL12A Gene

MGI Knock Outs for IL12A:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL12A

miRNA for IL12A Gene

miRTarBase miRNAs that target IL12A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for IL12A Gene

Localization for IL12A Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL12A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL12A Gene COMPARTMENTS Subcellular localization image for IL12A gene
Compartment Confidence
extracellular 5
plasma membrane 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for IL12A Gene

Pathways & Interactions for IL12A Gene

genes like me logo Genes that share pathways with IL12A: view

SIGNOR curated interactions for IL12A Gene

Activates:

Gene Ontology (GO) - Biological Process for IL12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity IDA 1674604
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IDA 7903063
GO:0007050 cell cycle arrest IDA 16942485
GO:0009615 response to virus IEP 16548883
GO:0032700 negative regulation of interleukin-17 production IDA 16482511
genes like me logo Genes that share ontologies with IL12A: view

Drugs & Compounds for IL12A Gene

(8) Drugs for IL12A Gene - From: DGIdb and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mycophenolate mofetil Approved, Investigational Pharma IMPDH inhibitor 898
humanized SMART Anti-IL-12 Antibody Investigational Pharma 0
AD-RTS-IL-12 Pharma 0
BRIAKINUMAB Pharma 0
DC-RTS-IL-12 Pharma 0
genes like me logo Genes that share compounds with IL12A: view

Transcripts for IL12A Gene

mRNA/cDNA for IL12A Gene

Unigene Clusters for IL12A Gene

Interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL12A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5:

Relevant External Links for IL12A Gene

GeneLoc Exon Structure for
IL12A
ECgene alternative splicing isoforms for
IL12A

Expression for IL12A Gene

mRNA expression in normal human tissues for IL12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL12A Gene

This gene is overexpressed in Esophagus - Mucosa (x6.7).

Protein differential expression in normal tissues from HIPED for IL12A Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL12A Gene



SOURCE GeneReport for Unigene cluster for IL12A Gene Hs.673

genes like me logo Genes that share expression patterns with IL12A: view

Protein tissue co-expression partners for IL12A Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IL12A Gene

Orthologs for IL12A Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL12A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL12A 35
  • 87.48 (n)
  • 83.25 (a)
IL12A 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL12A 35
  • 87.98 (n)
  • 84.93 (a)
IL12A 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il12a 35
  • 70.76 (n)
  • 59.65 (a)
Il12a 16
Il12a 36
  • 57 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL12A 35
  • 99.47 (n)
  • 99.6 (a)
IL12A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il12a 35
  • 72.09 (n)
  • 60 (a)
oppossum
(Monodelphis domestica)
Mammalia IL12A 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL12A 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL12A 36
  • 35 (a)
OneToOne
Species with no ortholog for IL12A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL12A Gene

ENSEMBL:
Gene Tree for IL12A (if available)
TreeFam:
Gene Tree for IL12A (if available)

Paralogs for IL12A Gene

No data available for Paralogs for IL12A Gene

Variants for IL12A Gene

Structural Variations from Database of Genomic Variants (DGV) for IL12A Gene

Variant ID Type Subtype PubMed ID
nsv829769 CNV Gain 17160897

Variation tolerance for IL12A Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL12A Gene

HapMap Linkage Disequilibrium report
IL12A
Human Gene Mutation Database (HGMD)
IL12A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for IL12A Gene

Disorders for IL12A Gene

MalaCards: The human disease database

(6) MalaCards diseases for IL12A Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
primary biliary cirrhosis
  • biliary liver cirrhosis
intracranial aneurysm
  • brain aneurysm
atypical autism
  • pdd nos
orchitis
  • inflammation of testis
behcet's disease
  • adamantiades-behcet disease
- elite association - COSMIC cancer census association via MalaCards
Search IL12A in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL12A

Genetic Association Database (GAD)
IL12A
Human Genome Epidemiology (HuGE) Navigator
IL12A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL12A
genes like me logo Genes that share disorders with IL12A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL12A Gene

Publications for IL12A Gene

  1. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. (PMID: 1673147) Wolf S.F. … Perussia B. (J. Immunol. 1991) 2 3 4 67
  2. Association of single nucleotide polymorphisms in the IL-12 (IL-12A and B) and IL-12 receptor (IL-12Rbeta1 and beta2) genes and gene-gene interactions with atopic dermatitis in Koreans. (PMID: 20060272) Namkung J.H. … Yang J.M. (J. Dermatol. Sci. 2010) 3 23
  3. Interactions of IL-12A and IL-12B polymorphisms on the risk of cervical cancer in Chinese women. (PMID: 19118071) Chen X. … Hu Z. (Clin. Cancer Res. 2009) 3 23
  4. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. (PMID: 19458352) Hirschfield G.M. … Siminovitch K.A. (N. Engl. J. Med. 2009) 3 23
  5. Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes. (PMID: 17152005) Dhiman N. … Jacobson R.M. (J. Infect. Dis. 2007) 3 23

Products for IL12A Gene

Sources for IL12A Gene

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