IL12A Gene

Aliases
for IL12A gene

Previous GC identifers: GC03P156994 GC03P160653 GC03P160988 GC03P161027 GC03P161189 GC03P157103

Summaries
for IL12A gene

Genomic Views
for IL12A gene

RefSeq DNA sequence:

NC_000003.11  NC_018914.1  NT_005612.16  

SwitchGear Promoter luciferase reporter plasmid: IL12A promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL12A

IL12A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P159706:  view genomic region     (about GC identifiers)

Proteins
for IL12A gene

2 PDB 3D structures from and Proteopedia for IL12A:

1F45 (3D)        3HMX (3D)    

Explore the universe of human proteins at neXtProt for IL12A: NX_P29459

IL12A Protein expression data from MOPED and PaxDb:    About this image 

	EMD Millipore Purified and/or Recombinant IL12A Protein
	R&D Systems Recombinant & Natural Proteins for IL12A (IL-12)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for IL12A
	GenScript Purified and Recombinant Proteins for IL12A
	Novus Biologicals IL12A Proteins Novus Biologicals IL12A Lysates
	Sino Biological Recombinant Protein for IL12A
	ProSpec Recombinant Protein for IL12A
	Uscn Proteins for IL12A

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IL12A
	R&D Systems Antibodies for IL12A (IL-12, IL-12 p70, IL-12/IL-35 p35)
	OriGene Antibodies: IL12A OriGene Custom Antibody Services for IL12A
	GenScript Custom Superior Antibodies Services for IL12A
	Novus Biologicals IL12A Antibodies
	Abcam antibodies for IL12A
	Uscn Antibodies for IL12A
	ThermoFisher Antibody for IL12A

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for IL12A (IL-12, IL-12 p70)         (see all)
	GenScript Custom Assay Services for IL12A
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IL12A

Protein Domains /
Families
for IL12A gene

ProtoNet protein and cluster: P29459

Function
for IL12A gene

miRNA Products:		OriGene 3'-UTR Clone: IL12A Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL12A
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate IL12A:
		hsa-miR-607 hsa-miR-590-5p hsa-miR-340 hsa-miR-21
		SwitchGear 3'UTR luciferase reporter plasmid: IL12A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL12A (see all 7) OriGene shRNA RFP: IL12A OriGene siRNA: IL12A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL12A

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for IL12A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL12A (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL12A OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL12A (NM_000882)
		Sino Biological Human cDNA Clone for IL12A
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL12A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL12A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL12A
		Search LifeMap BioReagents cell lines for IL12A

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL12A

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

(inferred from 2 alleles) (MGI details for Il12a)

Pathways & Interactions
for IL12A gene

	Super-pathway	contained gene-specific pathways
1	PEDF Induced Signaling	8/12 pathways (see all 12) PEDF Induced Signaling 1.00 STAT3 Pathway 0.47 MIF Mediated Glucocorticoid Regulation 0.73 Endothelin-1 Signaling Pathway 0.44 MIF Regulation of Innate Immune Cells 0.71 NFAT Signaling and Lymphocyte Interactions 0.37 IL-6 Pathway 0.61 PGC1Alpha Pathway 0.33
2	TGF-Beta Pathway	TGF-Beta Pathway 1.00 Regulation of eIF4 and p70S6K 0.43 MAPK Family Pathway 0.60 SOCS Pathway 0.29 JAK-STAT Pathway 0.57
3	IL27-mediated signaling events	IL27-mediated signaling events 1.00 Th1 Differentiation 0.38
4	Immune response IL-12-induced IFN-gamma production	Immune response IL-12-induced IFN-gamma production 1.00 IL12-mediated signaling events 0.33 Immune response_IL-12-induced IFN-gamma production 0.88
5	Akt Signaling	Akt Signaling 1.00 Tec Kinases Signaling 0.55 p38 Signaling 0.60

3 EMD Millipore Pathways for IL12A

	Immune response IL-12-induced IFN-gamma production
	Immune response IL-22 signaling pathway
	Immune response IL-12 signaling pathway

2 R&D Systems Pathways for IL12A

	Th1 Differentiation
	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL12A

	THC Differentiation Pathway
	MSP-RON Signaling
	TRAF Pathway
	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer

3 GeneGo (Thomson Reuters) Pathways for IL12A

	Immune response IL-12 signaling pathway
	Immune response IL-22 signaling pathway
	Immune response IL-12-induced IFN-gamma production

3 BioSystems Pathways for IL12A

	Toll-like receptor signaling pathway
	IL27-mediated signaling events
	IL12-mediated signaling events

5/16         Kegg Pathways  (Kegg details for IL12A)

	Cytokine-cytokine receptor interaction
	Toll-like receptor signaling pathway
	RIG-I-like receptor signaling pathway
	Jak-STAT signaling pathway
	Type I diabetes mellitus

Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

Drugs & Compounds
for IL12A gene

Transcripts
for IL12A gene

Expression
for IL12A gene

IL12A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGCATCTG

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)			Endothelium
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL12A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL12A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL12A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL12A

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL12A

Orthologs
for IL12A gene

Paralogs
for IL12A gene

Genomic Variants
for IL12A gene

10/187 NCBI SNPs in IL12A are shown (see all 187)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1487362291,2		--	159704628(+)	AAATCA/GGCTGA	1	--	us2k1		0	--	--	--	--
rs597193861,2	C,F,	--	159704641(+)	TTTTTT/AAAGTT	1	--	us2k1		3		WA	122
rs1457200411,2	C,	--	159704703(+)	ATTAA-/TTTTTT	1	--	us2k1		0	--	--	--	--
rs117183771,2	C,H,	--	159704719(+)	TTTTGC/Tatatc	1	--	us2k1		1		NA	2
rs1834027871,2		--	159704735(+)	TAAAAA/TGTGAC	1	--	us2k1		0	--	--	--	--
rs749818451,2		--	159704796(+)	CCTTAC/TAGCAT	1	--	us2k1		0	--	--	--	--
rs786644421,2	C,F,	--	159704806(+)	TTGGCC/TGAGAC	1	--	us2k1		1		NA	120
rs1871516761,2		--	159704807(+)	TGGCCA/GAGACC	1	--	us2k1		0	--	--	--	--
rs1415205311,2		--	159704880(+)	AATCAC/TGTATT	1	--	us2k1		0	--	--	--	--
rs1920708991,2		--	159705026(+)	AGCAAC/TAGAAA	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for IL12A (159706537 - 159713806 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for IL12A: --
Human Gene Mutation Database (HGMD): IL12A

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL12A

DNA2.0 Custom Variant and Variant Library Synthesis for IL12A

Disorders / Diseases
for IL12A gene

Publications
for IL12A gene

PubMed articles for IL12A gene, integrated from 9 sources (see all 271): (articles sorted by number of sources associating them with IL12A)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. (PubMed id 1673147)^{1, 2, 3} Wolf S.F....Perussia B. (1991)
2. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PubMed id 16548883)^{1, 2} Leong W.F. and Chow V.T. (2006)
3. Effect of cytokine genotypes on the hepatitis B virus-hepatocellular carcinoma association. (PubMed id 15643599)^{1, 4} Nieters A....Yu M.C. (2005)
4. Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene. (PubMed id 16230423)^{1, 4} Lan Q....Rothman N. (2005)
5. IL-12 and IL-10 polymorphisms and their effects on cytokine production. (PubMed id 15863393)^{1, 4} Yilmaz V....Saruhan-Direskeneli G. (2005)
6. Genetic approaches to assessing evidence for a T helper type 1 cytokine defect in adult asthma. (PubMed id 14962816)^{1, 4} Birkisson I.F....Hakonarson H. (2004)
7. Association of single nucleotide polymorphisms within cytokine genes with juvenile idiopathic arthritis in the Czech population. (PubMed id 15170937)^{1, 4} Cinek O....Slavcev A. (2004)
8. Cytokine gene polymorphisms in Taiwan. (PubMed id 15361128)^{1, 4} Trejaut J.A....Lin M. (2004)
9. Genomic analysis of Th1-Th2 cytokine genes in an AIDS cohort: identification of IL4 and IL10 haplotypes associated with the disease progression. (PubMed id 12944981)^{1, 4} Vasilescu A....Zagury J.F. (2003)
10. Cytokine gene single nucleotide polymorphisms and susceptibility to and prognosis in cutaneous malignant melanoma. (PubMed id 14675394)^{1, 4} Howell W.M....Bateman A.C. (2003)

External Searches for IL12A gene

Genome Databases showing IL12A gene

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Specialized Databases showing IL12A gene

Products
for IL12A gene