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IL12A Gene

protein-coding   GIFtS: 64
GCID: GC03P159706

Interleukin 12A (Natural Killer Cell Stimulatory Factor...


(Previous symbol: NKSF1)
  See IL12A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Interleukin 12A (Natural Killer Cell Stimulatory Factor 1, Cytotoxic
Lymphocyte Maturation Factor 1, P35)1 2
     Interleukin 121
NKSF11 2 3     Natural Killer Cell Stimulatory Factor 11
IL35 Subunit1 2     p351
Interleukin-12 Alpha Chain1 2     Subunit P351
NF Cell Stimulatory Factor Chain 11 2     CLMF2
Cytotoxic Lymphocyte Maturation Factor 35 KDa Subunit2 3     NFSK2
IL-12A2 3     P352
CLMF P352 3     Cytotoxic Lymphocyte Maturation Factor 1, P352
NK Cell Stimulatory Factor Chain 12 3     IL-12, Subunit P352
35 KD Subunit1     Interleukin 12, P352
IL-121     Interleukin-12 Subunit Alpha2
Cytotoxic Lymphocyte Maturation Factor 11     IL-12 Subunit P353

External Ids:    HGNC: 59691   Entrez Gene: 35922   Ensembl: ENSG000001688117   OMIM: 1615605   UniProtKB: P294593   
ORGUL members:         

Export aliases for IL12A gene to outside databases

Previous GC identifers: GC03P156994 GC03P160653 GC03P160988 GC03P161027 GC03P161189 GC03P157103


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL12A Gene:
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of
biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by
this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for
the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1
and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription
protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this
cytokine in innate immunity. (provided by RefSeq, Jul 2008)

GeneCards Summary for IL12A Gene:
IL12A (interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)) is a protein-coding gene. Diseases associated with IL12A include aphthous stomatitis, and primary biliary cirrhosis. GO annotations related to this gene include growth factor activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot: IL12A_HUMAN, P29459
Function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of
NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC

Gene Wiki entry for IL12A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL12A gene promoter:
         GCNF   MEF-2   NF-kappaB   Ik-3   MEF-2A   GCNF-1   aMEF-2   GCNF-2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL12A promoter sequence
   Search Chromatin IP Primers for IL12A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL12A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.33   Ensembl cytogenetic band:  3q25.33   HGNC cytogenetic band: 3q25.33

IL12A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL12A gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P159706:  view genomic region     (about GC identifiers)

Start:
159,706,537 bp from pter      End:
159,713,806 bp from pter
Size:
7,270 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL12A_HUMAN, P29459 (See protein sequence)
Recommended Name: Interleukin-12 subunit alpha precursor  
Size: 219 amino acids; 24874 Da
Subunit: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12
Sequence caution: Sequence=AAA59937.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for IL12A:
1F45 (3D)        3HMX (3D)    
Secondary accessions: Q96QZ1

Explore the universe of human proteins at neXtProt for IL12A: NX_P29459

Explore proteomics data for IL12A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn93, Asn107

  • See IL12A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000873.2  
    ENSEMBL proteins: 
     ENSP00000303231   ENSP00000420184   ENSP00000419046  

    IL12A Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for IL12A
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    Search eBioscience for Proteins for IL12A 

    IL12A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL12A
    R&D Systems Antibodies for IL12A (IL-12, IL-12 p70, IL-12/IL-35 p35)
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    Abcam antibodies for IL12A (P29459, P29460)
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    IL12A Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL12A
    Cloud-Clone Corp. CLIAs for IL12A
    eBioscience ELISAs for IL12A:  
                        Human IL-35 ELISA Ready-SET-Go! 2 x 96 tests w/plates


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    3 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR009079 4_helix_cytokine-like_core
     IPR004281 IL-12_alpha

    Graphical View of Domain Structure for InterPro Entry P29459

    ProtoNet protein and cluster: P29459

    1 Blocks protein domain: IPB004281 Interleukin-12 alpha subunit

    UniProtKB/Swiss-Prot: IL12A_HUMAN, P29459
    Similarity: Belongs to the IL-6 superfamily


    Find genes that share domains with IL12A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL12A_HUMAN, P29459
    Function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of
    NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC
    Induction: Down-regulated in response to enterovirus 71 (EV71) infection

         Genatlas biochemistry entry for IL12A:
    interleukin 12,alpha polypeptide (35kDa),dimerizing with IL12B,secreted by macrophages and dendritic
    cells,stimulating IFNG production

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125contributes to cytokine activity TAS1673147
    GO:0005143interleukin-12 receptor binding NAS1674604
    GO:0005515protein binding IPI10899108
    GO:0008083contributes to growth factor activity NAS1673147
    GO:0042163interleukin-12 beta subunit binding IEA--
         
    Find genes that share ontologies with IL12A           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Il12a):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  respiratory system 
     tumorigenesis 

    Find genes that share phenotypes with IL12A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for IL12A: Il12atm1Jm Il12atm1Cab

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL12A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL12A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL12A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL12A

    miRNA
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    miRTarBase miRNAs that target IL12A:
    hsa-mir-26b-5p (MIRT030009)

    Block miRNA regulation of human, mouse, rat IL12A using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate IL12A:
    hsa-miR-607 hsa-miR-590-5p hsa-miR-340 hsa-miR-21
    SwitchGear 3'UTR luciferase reporter plasmidIL12A 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat IL12A

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: IL12A (NM_000882)
    Sino Biological Human cDNA Clone for IL12A
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL12A

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL12A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL12A_HUMAN, P29459: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane2
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IDA16456693
    GO:0005737cytoplasm IEA--
    GO:0043514interleukin-12 complex NAS14718574

    Find genes that share ontologies with IL12A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL12A About   (see all 25)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Allograft rejection
    Allograft rejection0.86
    Type I diabetes mellitus0.69
    Allograft Rejection0.86
    THC Differentiation Pathway0.38
    2PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    3Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    Chagas disease (American trypanosomiasis)0.32
    4Th1 Differentiation
    IL27-mediated signaling events0.38
    Th1 Differentiation0.38
    5IL12-mediated signaling events
    Immune response IL 12 induced IFN gamma production0.33
    IL12-mediated signaling events0.33


    Find genes that share SuperPaths with IL12A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IL12A
        Th1 Differentiation
    IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL12A (see all 28)
        THC Differentiation Pathway
    MSP-RON Signaling
    TRAF Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer

    3 GeneGo (Thomson Reuters) Pathways for IL12A
        Immune response IL-12 signaling pathway
    Immune response IL-22 signaling pathway
    Immune response IL-12-induced IFN-gamma production

    5 BioSystems Pathways for IL12A
        Allograft Rejection
    Toll-like receptor signaling pathway
    IL27-mediated signaling events
    IL12-mediated signaling events
    Regulation of toll-like receptor signaling pathway



    Selected Kegg Pathways  (Kegg details for IL12A) (see all 19):
        Cytokine-cytokine receptor interaction
    Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    Jak-STAT signaling pathway
    Type I diabetes mellitus

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL12A (see all 14): 
              Growth Factors in human mouse rat
              Antiviral Response in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Leukemia in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL12A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL12A (P294591, 3 ENSP000003032314) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL12BP294601, 3, ENSP000002312284EBI-1029636,EBI-1029614 I2D: score=5 STRING: ENSP00000231228
    EBI3Q142133, ENSP000002218474I2D: score=4 STRING: ENSP00000221847
    CD28P107473, ENSP000003248904I2D: score=1 STRING: ENSP00000324890
    IL12RB1P427013, ENSP000003144254I2D: score=1 STRING: ENSP00000314425
    IL8P101453, ENSP000003065124I2D: score=1 STRING: ENSP00000306512
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001916positive regulation of T cell mediated cytotoxicity IDA1674604
    GO:0002860positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IDA7903063
    GO:0006955immune response TAS9789052
    GO:0007050cell cycle arrest IDA16942485
    GO:0009615response to virus IEP16548883

    Find genes that share ontologies with IL12A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL12A

    1 PharmGKB related drug/compound annotation for IL12A gene    About this table
    Drug/compound PharmGKB Annotation
    mycophenolate mofetilCA  



    Find genes that share compounds with IL12A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IL12A gene: 
    NM_000882.3  

    Unigene Cluster for IL12A:

    Interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
    Hs.673  [show with all ESTs]
    Unigene Representative Sequence: BC035571
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305579(uc003fcx.3) ENST00000480088 ENST00000468862 ENST00000496308
    ENST00000480787 ENST00000466512
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate IL12A:
    hsa-miR-607 hsa-miR-590-5p hsa-miR-340 hsa-miR-21
    SwitchGear 3'UTR luciferase reporter plasmidIL12A 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat IL12A

    Additional mRNA sequence: 

    AF101062.1 AF180562.1 BC035571.1 BC104982.1 BC104984.1 M65271.1 M65291.1 

    3 DOTS entries:

    DT.203502  DT.101981213  DT.101981212 

    18 AceView cDNA sequences:

    BI824638 NM_000882 AF180562 CD013915 AI803560 BC035571 AF101062 AU099435 
    M65271 AI304577 AI332701 BI523569 BG702253 CD013916 CD013914 M65291 
    AW472810 AU105695 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IL12A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                          -                                 
    SP2:                          -                                 
    SP3:                          -     -                           
    SP4:                    -     -                                 
    SP5:                                                            


    ECgene alternative splicing isoforms for IL12A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL12A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGCATCTG
    IL12A Expression
    About this image


    IL12A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     NULL (Uncategorized)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
    IL12A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL12A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.673
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL12A (see all 14): 
              Growth Factors in human mouse rat
              Antiviral Response in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Leukemia in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat IL12A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL12A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL12A gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il12a1 , 5 interleukin 12a1, 5 70.76(n)1
    59.65(a)1
      3 (31.92 cM)5
    161591  NM_001159424.11  NP_001152896.11 
     686906445 
    chicken
    (Gallus gallus)
    Aves IL12A6
    Gallus gallus interleukin 12A (natural killer cell...
    35(a)
    1 ↔ 1
    9(21727352-21729152)


    ENSEMBL Gene Tree for IL12A (if available)
    TreeFam Gene Tree for IL12A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL12A (see all 240)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113975221,2
    C--157102126(+) GACCCC/-TGGAT 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1487362291,2
    --159685421(+) AAATCA/GGCTGA 1 -- us2k10--------
    rs597193861,2
    C,F--159685434(+) TTTTTT/AAAGTT 1 -- us2k13Minor allele frequency- A:0.15WA 122
    rs1457200411,2
    C--159685496(+) ATTAA-/TTTTTT 1 -- us2k10--------
    rs117183771,2
    C,F,H--159685512(+) TTTTGC/Tatatc 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1834027871,2
    --159685528(+) TAAAAA/TGTGAC 1 -- us2k10--------
    rs749818451,2
    --159685589(+) CCTTAC/TAGCAT 1 -- us2k10--------
    rs786644421,2
    C,F--159685599(+) TTGGCC/TGAGAC 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1871516761,2
    --159685600(+) TGGCCA/GAGACC 1 -- us2k10--------
    rs1415205311,2
    --159685673(+) AATCAC/TGTATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IL12A (159706537 - 159713806 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL12A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829769CNV Gain17160897

    Human Gene Mutation Database (HGMD): IL12A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL12A
    DNA2.0 Custom Variant and Variant Library Synthesis for IL12A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 161560    OMIM disorders: --

    13 diseases for IL12A:    
    About MalaCards
    aphthous stomatitis    primary biliary cirrhosis    classic kaposi sarcoma    legionellosis
    takayasu's arteritis    stomatitis    carotid stenosis    polymyalgia rheumatica
    rubella    cerebral malaria    trypanosomiasis    idiopathic pulmonary fibrosis
    malaria


    Find genes that share disorders with IL12A           About GenesLikeMe

    Genetic Association Database (GAD): IL12A
    Human Genome Epidemiology (HuGE) Navigator: IL12A (121 documents)

    Export disorders for IL12A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL12A gene, integrated from 10 sources (see all 293):
    (articles sorted by number of sources associating them with IL12A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. (PubMed id 1673147)1, 2, 3 Wolf S.F....Perussia B. (J. Immunol. 1991)
    2. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. (PubMed id 19458352)1, 4, 9 Hirschfield G.M....Siminovitch K.A. (N. Engl. J. Med. 2009)
    3. Association of single nucleotide polymorphisms in the IL-12 (IL-12A and B) and IL-12 receptor (IL-12Rbeta1 and beta2) genes and gene-gene interactions with atopic dermatitis in Koreans. (PubMed id 20060272)1, 4, 9 Namkung J.H....Yang J.M. (J. Dermatol. Sci. 2010)
    4. Interactions of IL-12A and IL-12B polymorphisms on the risk of cervical cancer in Chinese women. (PubMed id 19118071)1, 4, 9 Chen X....Hu Z. (Clin. Cancer Res. 2009)
    5. Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes. (PubMed id 17152005)1, 4, 9 Dhiman N....Jacobson R.M. (J. Infect. Dis. 2007)
    6. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PubMed id 21399635)1, 4 Mells G.F....Anderson C.A. (Nat. Genet. 2011)
    7. Immunogenetic characteristics of patients with autoimmune gastritis. (PubMed id 20082482)1, 4 Oksanen A.M....Partanen J.A. (World J. Gastroenterol. 2010)
    8. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    9. Association of polymorphisms in the IL-18 and IL-12 genes with susceptibility to Type 1 diabetes in Turkish patients. (PubMed id 20061784)1, 4 Altinova A.E....Arslan M. (J. Endocrinol. Invest. 2010)
    10. Cytokine gene polymorphisms in sarcoidosis. (PubMed id 21086908)1, 4 Vasakova M....Striz I. (Sarcoidosis Vasc Diffuse Lung Dis 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3592 HGNC: 5969 AceView: IL12A Ensembl:ENSG00000168811 euGenes: HUgn3592
    ECgene: IL12A Kegg: 3592 H-InvDB: IL12A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IL12A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL12A Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_12
    SeattleSNPshttp://pga.gs.washington.edu/data/il12a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL12A gene:
    Search GeneIP for patents involving IL12A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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