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Aliases for IL11RA Gene

Aliases for IL11RA Gene

  • Interleukin 11 Receptor Subunit Alpha 2 3 5
  • Interleukin 11 Receptor, Alpha 2 3
  • IL-11 Receptor Subunit Alpha 3 4
  • IL-11R Subunit Alpha 3 4
  • Interleukin-11 Receptor Alpha Chain 3
  • IL-11R-Alpha 4
  • IL-11RA 4
  • CRSDA 3

External Ids for IL11RA Gene

Previous GeneCards Identifiers for IL11RA Gene

  • GC09P034966
  • GC09P034820
  • GC09P034640
  • GC09P034643

Summaries for IL11RA Gene

Entrez Gene Summary for IL11RA Gene

  • Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

GeneCards Summary for IL11RA Gene

IL11RA (Interleukin 11 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL11RA include craniosynostosis and dental anomalies and craniosynostosis. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include signal transducer activity and cytokine receptor activity. An important paralog of this gene is IL6R.

UniProtKB/Swiss-Prot for IL11RA Gene

  • Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.

Gene Wiki entry for IL11RA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL11RA Gene

Genomics for IL11RA Gene

Regulatory Elements for IL11RA Gene

Promoters for IL11RA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IL11RA on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the IL11RA gene promoter:

Genomic Location for IL11RA Gene

Chromosome:
9
Start:
34,650,702 bp from pter
End:
34,661,902 bp from pter
Size:
11,201 bases
Orientation:
Plus strand

Genomic View for IL11RA Gene

Genes around IL11RA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL11RA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL11RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL11RA Gene

Proteins for IL11RA Gene

  • Protein details for IL11RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14626-I11RA_HUMAN
    Recommended name:
    Interleukin-11 receptor subunit alpha
    Protein Accession:
    Q14626
    Secondary Accessions:
    • Q16542
    • Q5VZ80
    • Q7KYJ7

    Protein attributes for IL11RA Gene

    Size:
    422 amino acids
    Molecular mass:
    45222 Da
    Quaternary structure:
    • On ligand binding, forms a multimer complex with IL6ST/gp130.

    Alternative splice isoforms for IL11RA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL11RA Gene

Proteomics data for IL11RA Gene at MOPED

Post-translational modifications for IL11RA Gene

  • Glycosylation at Asn 127 and Asn 194
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for IL11RA (IL-11 R alpha)

No data available for DME Specific Peptides for IL11RA Gene

Domains & Families for IL11RA Gene

Graphical View of Domain Structure for InterPro Entry

Q14626

UniProtKB/Swiss-Prot:

I11RA_HUMAN :
  • Contains 2 fibronectin type-III domains.
  • Belongs to the type I cytokine receptor family. Type 3 subfamily.
Domain:
  • Contains 2 fibronectin type-III domains.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Family:
  • Belongs to the type I cytokine receptor family. Type 3 subfamily.
genes like me logo Genes that share domains with IL11RA: view

Function for IL11RA Gene

Molecular function for IL11RA Gene

GENATLAS Biochemistry:
interleukin 11,receptor,alpha chain with two alternatively spliced forms A1,A2
UniProtKB/Swiss-Prot Function:
Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.
genes like me logo Genes that share phenotypes with IL11RA: view

Human Phenotype Ontology for IL11RA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for IL11RA Gene

miRTarBase miRNAs that target IL11RA

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for IL11RA Gene

Localization for IL11RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL11RA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL11RA Gene COMPARTMENTS Subcellular localization image for IL11RA gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 2
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for IL11RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL11RA: view

Pathways & Interactions for IL11RA Gene

genes like me logo Genes that share pathways with IL11RA: view

Interacting Proteins for IL11RA Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000326500%0d%0a9606.ENSP00000264563%0d%0a
Selected Interacting proteins: ENSP00000326500 Q14626-I11RA_HUMAN for IL11RA Gene via STRING I2D

SIGNOR curated interactions for IL11RA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL11RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 7670098
GO:0060322 head development IMP 21741611
genes like me logo Genes that share ontologies with IL11RA: view

Drugs & Compounds for IL11RA Gene

(2) Drugs for IL11RA Gene - From: DGIdb, DrugBank, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oprelvekin Approved, Investigational Pharma binder, Target, agonist 16
Neumega Approved November 1997 Pharma 0

(1) Additional Compounds for IL11RA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL11RA: view

Transcripts for IL11RA Gene

Unigene Clusters for IL11RA Gene

Interleukin 11 receptor, alpha:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL11RA Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: - - - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: - - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - - - -
SP9: - - -

Relevant External Links for IL11RA Gene

GeneLoc Exon Structure for
IL11RA
ECgene alternative splicing isoforms for
IL11RA

Expression for IL11RA Gene

mRNA expression in normal human tissues for IL11RA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IL11RA Gene

This gene is overexpressed in Plasma (56.4) and Adipocyte (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL11RA Gene



SOURCE GeneReport for Unigene cluster for IL11RA Gene Hs.591088

mRNA Expression by UniProt/SwissProt for IL11RA Gene

Q14626-I11RA_HUMAN
Tissue specificity: Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2. Also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma.
genes like me logo Genes that share expression patterns with IL11RA: view

Protein tissue co-expression partners for IL11RA Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for IL11RA Gene

Orthologs for IL11RA Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL11RA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL11RA 36
  • 99 (a)
OneToMany
IL11RA 35
  • 99.45 (n)
  • 98.58 (a)
cow
(Bos Taurus)
Mammalia IL11RA 36
  • 86 (a)
OneToMany
IL11RA 35
  • 87.97 (n)
  • 85.51 (a)
dog
(Canis familiaris)
Mammalia IL11RA 35
  • 89.1 (n)
  • 88.63 (a)
-- 36
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Il11ra2 16
Gm13305 36
  • 81 (a)
ManyToMany
Il11ra1 36
  • 82 (a)
ManyToMany
Il11ra2 36
  • 81 (a)
ManyToMany
IL11RA2 36
  • 81 (a)
ManyToMany
IL11RA2 36
  • 81 (a)
ManyToMany
Il11ra1 35
  • 83.89 (n)
  • 83.89 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 59 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 45 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Il11ra1 35
  • 83.49 (n)
  • 82.23 (a)
chicken
(Gallus gallus)
Aves IL11RA 35
  • 58.97 (n)
  • 50.86 (a)
IL11RA 36
  • 50 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia il11ra 35
  • 54.35 (n)
  • 48.28 (a)
zebrafish
(Danio rerio)
Actinopterygii il11ra 36
  • 28 (a)
OneToMany
il11ra 35
  • 44.35 (n)
  • 33.62 (a)
Species with no ortholog for IL11RA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL11RA Gene

ENSEMBL:
Gene Tree for IL11RA (if available)
TreeFam:
Gene Tree for IL11RA (if available)

Paralogs for IL11RA Gene

Paralogs for IL11RA Gene

genes like me logo Genes that share paralogs with IL11RA: view

Variants for IL11RA Gene

Sequence variations from dbSNP and Humsavar for IL11RA Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs11575589 - 34,656,770(+) GGGAG(A/C)CAAAG nc-transcript-variant, reference, missense
rs11575580 - 34,660,867(+) TGAGA(C/T)GGGGT nc-transcript-variant, reference, missense
VAR_066666 Craniosynostosis and dental anomalies (CRSDA)
VAR_066667 Craniosynostosis and dental anomalies (CRSDA)
VAR_066668 Craniosynostosis and dental anomalies (CRSDA)

Structural Variations from Database of Genomic Variants (DGV) for IL11RA Gene

Variant ID Type Subtype PubMed ID
nsv893038 CNV Loss 21882294
nsv818699 CNV Gain 17921354
nsv831544 CNV Gain 17160897

Variation tolerance for IL11RA Gene

Residual Variation Intolerance Score: 52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL11RA Gene

HapMap Linkage Disequilibrium report
IL11RA
Human Gene Mutation Database (HGMD)
IL11RA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL11RA Gene

Disorders for IL11RA Gene

MalaCards: The human disease database

(4) MalaCards diseases for IL11RA Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
craniosynostosis and dental anomalies
  • crsda
craniosynostosis
  • premature closure of cranial sutures
cole-carpenter syndrome 2
  • clcrp2
molluscum contagiosum
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

I11RA_HUMAN
  • Craniosynostosis and dental anomalies (CRSDA) [MIM:614188]: A disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly. {ECO:0000269 PubMed:21741611}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IL11RA

Genetic Association Database (GAD)
IL11RA
Human Genome Epidemiology (HuGE) Navigator
IL11RA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL11RA
genes like me logo Genes that share disorders with IL11RA: view

No data available for Genatlas for IL11RA Gene

Publications for IL11RA Gene

  1. Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13. (PMID: 8808281) Van Leuven F. … Gossler A. (Genomics 1996) 2 3 4 23 67
  2. Interleukin 11 inhibits human trophoblast invasion indicating a likely role in the decidual restraint of trophoblast invasion during placentation. (PMID: 18987331) Paiva P. … Dimitriadis E. (Biol. Reprod. 2009) 3 23
  3. Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the invasive activity of human gastric carcinoma cells. (PMID: 17332920) Nakayama T. … Sekin I. (Int. J. Oncol. 2007) 3 23
  4. Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells. (PMID: 16964382) Yoshizaki A. … Sekine I. (Int. J. Oncol. 2006) 3 23
  5. Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: high expression of interleukin-11 receptor alpha. (PMID: 16291580) Karube K. … Harada M. (Ann. Oncol. 2006) 3 23

Products for IL11RA Gene

Sources for IL11RA Gene

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