Aliases for IL11RA Gene
External Ids for IL11RA Gene
Previous GeneCards Identifiers for IL11RA Gene
Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
GeneCards Summary for IL11RA Gene
IL11RA (Interleukin 11 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL11RA include Craniosynostosis And Dental Anomalies and Hallermann-Streiff Syndrome. Among its related pathways are Innate Immune System and TGF-Beta Pathway. GO annotations related to this gene include signal transducer activity and cytokine receptor activity. An important paralog of this gene is ENSG00000258728.
UniProtKB/Swiss-Prot for IL11RA Gene
Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.