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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL11 Gene

protein-coding   GIFtS: 65
GCID: GC19M055875

Interleukin 11

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 111 2     IL-112 3
Adipogenesis Inhibitory Factor1 2 3     interleukin-112
oprelvekin1 2     Oprelvekin3
AGIF2 3     

External Ids:    HGNC: 59661   Entrez Gene: 35892   Ensembl: ENSG000000957527   OMIM: 1476815   UniProtKB: P208093   

Export aliases for IL11 gene to outside databases

Previous GC identifers: GC19M056740 GC19M056300 GC19M060551 GC19M060567 GC19M052197


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL11 Gene:
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly
of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling
receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of
immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and
megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been
found for this gene. (provided by RefSeq, Jun 2012)

GeneCards Summary for IL11 Gene: 
IL11 (interleukin 11) is a protein-coding gene. Diseases associated with IL11 include hypersplenism, and osteitis fibrosa, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Immune response TLR signaling pathways. GO annotations related to this gene include growth factor activity and interleukin-11 receptor binding.

UniProtKB/Swiss-Prot: IL11_HUMAN, P20809
Function: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and
induces megakaryocyte maturation resulting in increased platelet production

Gene Wiki entry for IL11 (Interleukin 11) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL11 gene promoter:
         NF-1   Pax-5   AML1a   STAT5A   HEN1   PPAR-gamma1   STAT3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IL11 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3-q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.3-q13.4

IL11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL11 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M055875:  view genomic region     (about GC identifiers)

Start:
55,875,757 bp from pter      End:
55,881,831 bp from pter
Size:
6,075 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL11_HUMAN, P20809 (See protein sequence)
Recommended Name: Interleukin-11 precursor  
Size: 199 amino acids; 21429 Da
Subcellular location: Secreted
Secondary accessions: B4DQV5 Q96EB4
Alternative splicing: 2 isoforms:  P20809-1   P20809-2   

Explore the universe of human proteins at neXtProt for IL11: NX_P20809

Explore proteomics data for IL11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20809

  • IL11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IL11 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000632.1  NP_001254647.1  

    ENSEMBL proteins: 
     ENSP00000264563   ENSP00000465705   ENSP00000467355   ENSP00000468663  

    Human Recombinant Protein Products for IL11: 
    EMD Millipore Purified and/or Recombinant IL11 Protein
    R&D Systems Recombinant & Natural Proteins for IL11 (IL-11)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IL11
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for IL11
    GenScript Purified and Recombinant Proteins for IL11
    Novus Biologicals IL11 Proteins
    Novus Biologicals IL11 Lysate
    Sino Biological Recombinant Protein for IL11
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for IL11
    Cloud-Clone Corp. Proteins for IL11 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IC2145578
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IEA--

    IL11 for ontologies           About GeneDecksing



    IL11 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for IL11 (IL-11)
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    Novus Biologicals IL11 Antibodies
    Abcam antibodies for IL11
    Cloud-Clone Corp. Antibodies for IL11 
    ThermoFisher Antibodies for IL11
    LSBio Antibodies in human, mouse, rat for IL11 

    Assay Products for IL11: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL11
    R&D Systems ELISAs for IL11 (IL-11)         (see all)
    GenScript Custom Assay Services for IL11
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IL11 
    Cloud-Clone Corp. CLIAs for IL11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IL: Interleukins and interleukin receptors

    3 InterPro protein domains:
     IPR020438 Interleukin-11
     IPR009079 4_helix_cytokine-like_core
     IPR020412 Interleukin-11_mammalian

    Graphical View of Domain Structure for InterPro Entry P20809

    ProtoNet protein and cluster: P20809

    UniProtKB/Swiss-Prot: IL11_HUMAN, P20809
    Similarity: Belongs to the IL-6 superfamily


    IL11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL11_HUMAN, P20809
    Function: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and
    induces megakaryocyte maturation resulting in increased platelet production

         Genatlas biochemistry entry for IL11:
    interleukin 11,40kDa,interleukin-6 cytokine family member,stimulating the proliferation of B cells,T cell
    dependent

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005142interleukin-11 receptor binding NAS2145578
    GO:0008083growth factor activity IDA2145578
         
    IL11 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IL11:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IL11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL11 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL11 

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL11:
    hsa-mir-204 (MIRT005829)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL11
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate IL11 (see all 26):
    hsa-miR-548j hsa-miR-3910 hsa-miR-548i hsa-miR-124 hsa-miR-149 hsa-miR-23a hsa-miR-548a-5p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidIL11 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL11

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for IL11
    Sirion Biotech Customized adenovirus for overexpression of IL11

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IL11 (see all 7)
    OriGene ORF clones in mouse, rat for IL11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL11 (NM_000641)
    Sino Biological Human cDNA Clone for IL11
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL11
    Sirion Biotech Customized lentivirus for stable overexpression of IL11 
                         Customized lentivirus expression plasmids for stable overexpression of IL11 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IL11
    Search LifeMap BioReagents cell lines for IL11
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IL11 About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response0.94
    Immune response TLR signaling pathways0.94
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    MAPK Family Pathway0.60
    SOCS Pathway0.40
    JAK-STAT Pathway0.57
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for IL11
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

    5/26 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL11 (see all 26)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    Signaling Involved in Cardiac Hypertrophy

    1 GeneGo (Thomson Reuters) Pathway for IL11
        Immune response TLR signaling pathways

    2 BioSystems Pathways for IL11
        Interleukin-11 Signaling Pathway
    Integrated Pancreatic Cancer Pathway



    4         Kegg Pathways  (Kegg details for IL11):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    Hematopoietic cell lineage
    Rheumatoid arthritis


    IL11 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL11

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for IL11 (P208092, 3 ENSP000002645634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGEA11P433642, 3, ENSP000003473584MINT-68236 I2D: score=6 STRING: ENSP00000347358
    IL6STP401893, ENSP000003387994I2D: score=1 STRING: ENSP00000338799
    IL11RAQ146263, ENSP000003265004I2D: score=3 STRING: ENSP00000326500
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling IC2145578
    GO:0008284positive regulation of cell proliferation IDA2145578
    GO:0030168platelet activation NAS--
    GO:0030183B cell differentiation NAS2145578
    GO:0030219megakaryocyte differentiation NAS2145578

    IL11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IL11 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for IL11

    Browse Tocris compounds for IL11

    UniProtKB/Swiss-Prot: IL11_HUMAN, P20809
    Pharmaceutical: Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and
    the reduction of the need for platelet transfusion following myelosuppressive chemotherapy

    10/91 Novoseek inferred chemical compound relationships for IL11 gene (see all 91)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    il 11 95.1 129 12005542 (10), 20074812 (8), 1386338 (6), 19144959 (6) (see all 30)
    gp 130 91.2 136 10948192 (7), 9560294 (5), 10692570 (4), 8940087 (3) (see all 72)
    cdp571 75.5 1 16985094 (1)
    pixy321 63.5 4 7527667 (1), 9922079 (1), 8692093 (1), 7535842 (1)
    rantes 49.5 13 10366103 (2), 12620497 (2), 15025215 (2), 9764576 (1) (see all 10)
    methylcellulose 49.4 2 9216732 (1)
    gm-csf 36 2 9876771 (1), 18086169 (1)
    infliximab 34 1 12501498 (1)
    tyrosine 33.7 30 8174677 (5), 8360477 (2), 8398901 (2), 10725745 (2) (see all 14)
    etanercept 29.1 1 16985094 (1)

    Search CenterWatch for drugs/clinical trials and news about IL11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IL11 gene (2 alternative transcripts): 
    NM_000641.3  NM_001267718.1  

    Unigene Cluster for IL11:

    Interleukin 11
    Hs.467304  [show with all ESTs]
    Unigene Representative Sequence: NM_000641
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264563(uc002qks.1 uc010yfx.1) ENST00000590625 ENST00000585513
    ENST00000587093

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL11
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate IL11 (see all 26):
    hsa-miR-548j hsa-miR-3910 hsa-miR-548i hsa-miR-124 hsa-miR-149 hsa-miR-23a hsa-miR-548a-5p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidIL11 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IL11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL11
    Clone
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    OriGene clones in human, mouse for IL11 (see all 7)
    OriGene ORF clones in mouse, rat for IL11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL11 (NM_000641)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL11
    Sirion Biotech Customized lentivirus for stable overexpression of IL11 
                         Customized lentivirus expression plasmids for stable overexpression of IL11 
    Primer
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    OriGene qPCR primer pairs and template standards for IL11
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL11
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL11

    Additional mRNA sequence: 

    AK290572.1 AK298973.1 AK315294.1 BC012506.1 M57765.1 X58377.1 

    2 DOTS entries:

    DT.95254878  DT.102821513 

    24/36 AceView cDNA sequences (see all 36):

    M57765 NM_000641 BF056320 AI744579 BF055151 BX103627 BC012506 N95545 
    BV202913 X58377 AI128942 AI079412 AI073648 CA444136 AI620537 AI148233 
    BQ102335 CK822837 BQ102222 BF439402 W24348 CA444344 AW779662 T29611 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IL11 expression in normal human tissues (normalized intensities)      IL11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACATTTTA
    IL11 Expression
    About this image


    IL11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
     
     Bone (Muscoskeletal System)
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells

     -- (Integumentary System)
             SKIN   

    See IL11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IL11

    SOURCE GeneReport for Unigene cluster: Hs.467304
        SABiosciences Expression via Pathway-Focused PCR Arrays including IL11 (see all 8): 
              Growth Factors in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for IL11
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL11
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL11
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IL11 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il111 , 5 interleukin 111, 5 82.91(n)1
    87.94(a)1
      7 (2.76 cM)5
    161561  NM_008350.41  NP_032376.11 
     47730555 
    lizard
    (Anolis carolinensis)
    Reptilia IL116
    Uncharacterized protein
    44(a)
    1 ↔ 1
    GL343279.1(1293779-1296637)
    zebrafish
    (Danio rerio)
    Actinopterygii il11a6
    interleukin 11a
    21(a)
    1 ↔ 1
    16(14359727-14366281)


    ENSEMBL Gene Tree for IL11 (if available)
    TreeFam Gene Tree for IL11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/167 SNPs in IL11 are shown (see all 167)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs42525611,2
    C,F,A,H--55876654(-) tgcaaC/Gctcca 2 -- ut31 ese36Minor allele frequency- G:0.22NS NA 100
    rs42395921,2
    C,F,H--55876667(-) AATCTA/GAGGTC 2 -- ut31 ese313Minor allele frequency- G:0.07NS NA WA CSA EA 348
    rs104249561,2
    A--55876676(+) ttgccA/Tcactg 2 -- ut31 ese30--------
    rs19026081,2
    C,F,A,H--55876732(+) ACAAAC/AGGCCC 2 -- ut3114Minor allele frequency- A:0.06NS NA WA CSA EA 468
    rs42395931,2
    C,F,A--55876747(-) GCCCCG/ACACTG 2 -- ut31 ese37Minor allele frequency- A:0.10NS NA WA CSA 336
    rs42525601,2
    C,F--55876829(-) CCCGAG/CTGGGC 2 -- ut31 ese35Minor allele frequency- C:0.16NS WA 216
    rs42525591,2
    C,F,H--55876875(-) ACTGGG/AGCAGG 2 -- ut31 ese315Minor allele frequency- A:0.10NS EA NA WA 1266
    rs10425061,2
    C,F,O,H--55877111(-) GTCTGT/GCCACA 2 -- ut31 ese328Minor allele frequency- G:0.11NS MN EA NA WA 3412
    rs1865264041,2
    --55877122(+) TTCTTA/GGAGAC 2 -- ut310--------
    rs1907232491,2
    --55877138(+) AATCCA/GGGACC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for IL11 (55875757 - 55881831 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for IL11 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912466CNV Loss21882294
    dgv4017n71CNV Loss21882294
    nsv912461CNV Loss21882294
    nsv516199CNV Loss19592680
    nsv912463CNV Loss21882294
    dgv4018n71CNV Loss21882294
    nsv912473CNV Loss21882294
    nsv912457CNV Loss21882294
    dgv4016n71CNV Loss21882294
    dgv4019n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147681    OMIM disorders: --

    20/121 diseases for IL11 (see all 121):    About MalaCards
    hypersplenism    osteitis fibrosa    thrombocytosis    dengue disease
    joint disorders    plasmacytoma    von willebrand's disease    thrombocytopenia
    periodontal disease    osteoporosis, postmenopausal    megakaryocytic leukemia    refractory anemia
    hepatocellular adenoma    thyrotoxicosis    rheumatic disease    endometriosis
    purpura    iron deficiency anemia    osteosclerosis    periostitis

    1 disease from the University of Copenhagen DISEASES database for IL11:
    Thrombocytopenia

    IL11 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/92 Novoseek inferred disease relationships for IL11 gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 75.7 215 8145045 (2), 9182920 (2), 19647472 (2), 8601708 (2) (see all 99)
    thrombocytopenia 73.1 131 18629842 (5), 8896400 (4), 15120938 (3), 9474925 (3) (see all 75)
    plasmacytoma 60.2 12 1532843 (3), 7494003 (1), 1450406 (1), 8145046 (1) (see all 9)
    thrombocytosis 59.3 8 11843834 (1), 15543003 (1), 7689197 (1), 12478901 (1) (see all 6)
    necrosis 58.2 94 11675407 (3), 10022397 (2), 15543003 (2), 9811056 (2) (see all 76)
    myeloma 54 35 10572104 (4), 15377473 (3), 1532843 (3), 7647014 (2) (see all 17)
    osteolytic 52.1 15 9488033 (2), 11410329 (1), 14600590 (1), 10652584 (1) (see all 12)
    mucositis 51.6 18 10899677 (3), 10360368 (2), 9245489 (2), 11045187 (1) (see all 8)
    response acute phase 51.1 8 1281789 (1), 12773095 (1), 9876901 (1), 9416001 (1) (see all 6)
    inflammatory bowel diseases 50.6 10 10950118 (1), 15992047 (1), 16292518 (1), 9881950 (1) (see all 7)

    Genetic Association Database (GAD): IL11
    Human Genome Epidemiology (HuGE) Navigator: IL11 (10 documents)

    Export disorders for IL11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IL11 gene, integrated from 9 sources (see all 930):
    (articles sorted by number of sources associating them with IL11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic sequence and chromosomal location of human interleukin-11 gene (IL11). (PubMed id 1386338)1, 2, 3, 9 McKinley D.... Yang Y.C. (1992)
    2. A polymorphism in the IL11 gene is associated with ulcerative colitis. (PubMed id 12486609)1, 4, 9 Klein W....Epplen J.T. (2002)
    3. Genome-wide pharmacogenetics of antidepressant respon se in the GENDEP project. (PubMed id 20360315)1, 4, 9 Uher R....McGuffin P. (2010)
    4. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    5. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    6. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. A promotor polymorphism in the Interleukin 11 gene is associated with chronic obstructive pulmonary disease. (PubMed id 15004839)1, 4 Klein W....Epplen J.T. (2004)
    9. Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11. (PubMed id 1828438)1, 2 Kawashima I.... Takiguchi Y. (1991)
    10. Molecular cloning of a cDNA encoding interleukin 11, a stromal cell- derived lymphopoietic and hematopoietic cytokine. (PubMed id 2145578)1, 2 Paul S.R....Yang Y.-C. (1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3589 HGNC: 5966 AceView: IL11 Ensembl:ENSG00000095752 euGenes: HUgn3589
    ECgene: IL11 Kegg: 3589 H-InvDB: IL11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IL11 Pharmacogenomics, SNPs, Pathways
    Neumegahttp://www.drugs.com/cdi/neumega.html
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_11
    SeattleSNPshttp://pga.gs.washington.edu/data/il11/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IL11 gene:
    Search GeneIP for patents involving IL11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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