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IL11 Gene

protein-coding   GIFtS: 63
GCID: GC19M055875

Interleukin 11

  See IL11-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 111 2     IL-112 3
Adipogenesis Inhibitory Factor1 2 3     interleukin-112
oprelvekin1 2     Oprelvekin3
AGIF2 3     

External Ids:    HGNC: 59661   Entrez Gene: 35892   Ensembl: ENSG000000957527   OMIM: 1476815   UniProtKB: P208093   

Export aliases for IL11 gene to outside databases

Previous GC identifers: GC19M056740 GC19M056300 GC19M060551 GC19M060567 GC19M052197


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL11 Gene:
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly
of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling
receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of
immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and
megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been
found for this gene. (provided by RefSeq, Jun 2012)

GeneCards Summary for IL11 Gene:
IL11 (interleukin 11) is a protein-coding gene. Diseases associated with IL11 include periostitis, and hemorrhagic cystitis. GO annotations related to this gene include cytokine activity and interleukin-11 receptor binding.

UniProtKB/Swiss-Prot: IL11_HUMAN, P20809
Function: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and
induces megakaryocyte maturation resulting in increased platelet production

Gene Wiki entry for IL11 (Interleukin 11) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL11 gene promoter:
         NF-1   Pax-5   AML1a   STAT5A   HEN1   PPAR-gamma1   STAT3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IL11 promoter sequence
   Search Chromatin IP Primers for IL11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3-q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.3-q13.4

IL11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL11 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M055875:  view genomic region     (about GC identifiers)

Start:
55,875,757 bp from pter      End:
55,881,831 bp from pter
Size:
6,075 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IL11_HUMAN, P20809 (See protein sequence)
Recommended Name: Interleukin-11 precursor  
Size: 199 amino acids; 21429 Da
Secondary accessions: B4DQV5 Q96EB4
Alternative splicing: 2 isoforms:  P20809-1   P20809-2   

Explore the universe of human proteins at neXtProt for IL11: NX_P20809

Explore proteomics data for IL11 at MOPED


See IL11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_000632.1  NP_001254647.1  

ENSEMBL proteins: 
 ENSP00000264563   ENSP00000465705   ENSP00000467355   ENSP00000468663  

IL11 Human Recombinant Protein Products:

EMD Millipore Purified and/or Recombinant IL11 Protein
R&D Systems Recombinant & Natural Proteins for IL11 (IL-11)
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for IL11
OriGene Protein Over-expression Lysate for IL11
OriGene Custom MassSpec
OriGene Custom Protein Services for IL11
GenScript Purified and Recombinant Proteins for IL11
Novus Biologicals IL11 Proteins
Novus Biologicals IL11 Lysate
Sino Biological Recombinant Protein for IL11
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for IL11
Cloud-Clone Corp. Proteins for IL11

 
Search eBioscience for Proteins for IL11 

IL11 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for IL11 (IL-11)
Browse OriGene Antibodies
OriGene Custom Antibody Services for IL11
Novus Biologicals IL11 Antibodies
Abcam antibodies for IL11
Cloud-Clone Corp. Antibodies for IL11
ThermoFisher Antibodies for IL11
LSBio Antibodies in human, mouse, rat for IL11

IL11 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for IL11
R&D Systems ELISAs for IL11 (IL-11)         (see all)
GenScript Custom Assay Services for IL11
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for IL11
Cloud-Clone Corp. CLIAs for IL11
Search eBioscience for ELISAs for IL11 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands
IL: Interleukins and interleukin receptors

3 InterPro protein domains:
 IPR020438 IL-11
 IPR009079 4_helix_cytokine-like_core
 IPR020412 IL-11_mml

Graphical View of Domain Structure for InterPro Entry P20809

ProtoNet protein and cluster: P20809

UniProtKB/Swiss-Prot: IL11_HUMAN, P20809
Similarity: Belongs to the IL-6 superfamily


Find genes that share domains with IL11           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: IL11_HUMAN, P20809
Function: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and
induces megakaryocyte maturation resulting in increased platelet production

     Genatlas biochemistry entry for IL11:
interleukin 11,40kDa,interleukin-6 cytokine family member,stimulating the proliferation of B cells,T cell
dependent

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
GO:0005142interleukin-11 receptor binding NAS2145578
GO:0008083growth factor activity IDA2145578
     
Find genes that share ontologies with IL11           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for IL11:
 Increased cell death HMECs cel 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL11
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL11

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL11
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL11

miRNA
Products:
    
miRTarBase miRNAs that target IL11:
hsa-mir-1 (MIRT023653), hsa-mir-204-5p (MIRT005829), hsa-mir-379-5p (MIRT007025), hsa-mir-211-5p (MIRT007023), hsa-mir-124-3p (MIRT022448)

Block miRNA regulation of human, mouse, rat IL11 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate IL11 (see all 26):
hsa-miR-548j hsa-miR-3910 hsa-miR-548i hsa-miR-124 hsa-miR-149 hsa-miR-23a hsa-miR-548a-5p hsa-miR-548d-5p
SwitchGear 3'UTR luciferase reporter plasmidIL11 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for IL11
Predesigned siRNA for gene silencing in human, mouse, rat IL11

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IL11

Clone
Products:
     
OriGene clones in human, mouse for IL11 (see all 6)
OriGene ORF clones in mouse, rat for IL11
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL11 (NM_000641)
Sino Biological Human cDNA Clone for IL11
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL11
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL11

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IL11
Browse ESI BIO Cell Lines and PureStem Progenitors for IL11 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL11


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
IL11_HUMAN, P20809: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
nucleus2
mitochondrion1
plasma membrane1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IC2145578
GO:0005615extracellular space IEA--
GO:0005737cytoplasm IEA--

Find genes that share ontologies with IL11           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for IL11 About   (see all 12)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Regulation of Innate Immune Cells0.94
NFAT Signaling and Lymphocyte Interactions0.57
MIF Mediated Glucocorticoid Regulation0.94
PGC1Alpha Pathway0.51
PEDF Induced Signaling0.73
STAT3 Pathway0.47
all-trans-Retinoic Acid Signaling in Brain0.71
Endothelin-1 Signaling Pathway0.46
2TGF-Beta Pathway
TGF-Beta Pathway0.60
Regulation of eIF4 and p70S6K0.43
MAPK Family Pathway0.60
SOCS Pathway0.40
JAK-STAT Pathway0.57
3Akt Signaling
Akt Signaling0.60
Tec Kinases Signaling0.55
p38 Signaling0.60
4ERK Signaling
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61
5PAK Pathway
PAK Pathway0.56
Antioxidant Action of Vitamin-C0.56


Find genes that share SuperPaths with IL11           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL11 (see all 26)
    Endothelin-1 Signaling Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
NFAT Signaling and Lymphocyte Interactions
Signaling Involved in Cardiac Hypertrophy

1 GeneGo (Thomson Reuters) Pathway for IL11
    Immune response TLR signaling pathways

2 BioSystems Pathways for IL11
    Interleukin-11 Signaling Pathway
Integrated Pancreatic Cancer Pathway



4 Kegg Pathways  (Kegg details for IL11):
    Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Hematopoietic cell lineage
Rheumatoid arthritis

    Pathway & Disease-focused RT2 Profiler PCR Arrays including IL11 (see all 8): 
          Growth Factors in human mouse rat
          T-cell & B-cell Activation in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Endothelial Cell Biology in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat

Interactions:

    GeneGlobe Interaction Network for IL11

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for IL11 (P208092, 3 ENSP000002645634) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
MAGEA11P433642, 3, ENSP000003473584MINT-68236 I2D: score=6 STRING: ENSP00000347358
IL6STP401893, ENSP000003387994I2D: score=1 STRING: ENSP00000338799
IL11RAQ146263, ENSP000003265004I2D: score=3 STRING: ENSP00000326500
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Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007267cell-cell signaling IC2145578
GO:0008284positive regulation of cell proliferation IDA2145578
GO:0030168platelet activation ----
GO:0030183B cell differentiation NAS2145578
GO:0030219megakaryocyte differentiation NAS2145578

Find genes that share ontologies with IL11           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Enzo Life Sciences drugs & compounds for IL11
  Browse compounds at ApexBio 

Browse Tocris compounds for IL11

UniProtKB/Swiss-Prot: IL11_HUMAN, P20809
Pharmaceutical: Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and
the reduction of the need for platelet transfusion following myelosuppressive chemotherapy

Selected Novoseek inferred chemical compound relationships for IL11 gene (see all 91)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
il 11 95.1 129 12005542 (10), 20074812 (8), 1386338 (6), 19144959 (6) (see all 30)
gp 130 91.2 136 10948192 (7), 9560294 (5), 10692570 (4), 8940087 (3) (see all 72)
cdp571 75.5 1 16985094 (1)
pixy321 63.5 4 7527667 (1), 9922079 (1), 8692093 (1), 7535842 (1)
rantes 49.5 13 10366103 (2), 12620497 (2), 15025215 (2), 9764576 (1) (see all 10)
methylcellulose 49.4 2 9216732 (1)
gm-csf 36 2 9876771 (1), 18086169 (1)
infliximab 34 1 12501498 (1)
tyrosine 33.7 30 8174677 (5), 8360477 (2), 8398901 (2), 10725745 (2) (see all 14)
etanercept 29.1 1 16985094 (1)



Find genes that share compounds with IL11           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for IL11 gene (2 alternative transcripts): 
NM_000641.3  NM_001267718.1  

Unigene Cluster for IL11:

Interleukin 11
Hs.467304  [show with all ESTs]
Unigene Representative Sequence: NM_000641
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000264563(uc002qks.1 uc010yfx.1) ENST00000590625 ENST00000585513
ENST00000587093
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat IL11 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate IL11 (see all 26):
hsa-miR-548j hsa-miR-3910 hsa-miR-548i hsa-miR-124 hsa-miR-149 hsa-miR-23a hsa-miR-548a-5p hsa-miR-548d-5p
SwitchGear 3'UTR luciferase reporter plasmidIL11 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for IL11
Predesigned siRNA for gene silencing in human, mouse, rat IL11
Clone
Products:
     
OriGene clones in human, mouse for IL11 (see all 6)
OriGene ORF clones in mouse, rat for IL11
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL11 (NM_000641)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL11
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL11
Primer
Products:
    
OriGene qPCR primer pairs and template standards for IL11
OriGene qSTAR qPCR primer pairs in human, mouse for IL11
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL11
  QuantiTect SYBR Green Assays in human, mouse, rat IL11
  QuantiFast Probe-based Assays in human, mouse, rat IL11

Additional mRNA sequence: 

AK290572.1 AK298973.1 AK315294.1 BC012506.1 M57765.1 X58377.1 

2 DOTS entries:

DT.95254878  DT.102821513 

Selected AceView cDNA sequences (see all 36):

BF056320 NM_000641 AI744579 M57765 BC012506 BF055151 AI620537 AI073648 
BQ102222 X58377 N95545 AI079412 BX103627 AI148233 AI128942 CA444136 
BV202913 BQ102335 CK822837 CK822838 CA444344 T29611 AW779662 AI095314 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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IL11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACACATTTTA
IL11 Expression
About this image


IL11 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Bone marrow-derived mesenchymal stem cells
 
 Mesenchymal Stem Cells
         Bone marrow-derived mesenchymal stem cells
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Muscle Progenitor Cells Mandibular Arch Muscles
 
 Pancreas (Endocrine System)
 
 Fibroblasts (Uncategorized)
IL11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

IL11 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.467304
    Pathway & Disease-focused RT2 Profiler PCR Arrays including IL11 (see all 8): 
          Growth Factors in human mouse rat
          T-cell & B-cell Activation in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Endothelial Cell Biology in human mouse rat
          Inflammatory Cytokines & Receptors in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for IL11
OriGene qSTAR qPCR primer pairs in human, mouse for IL11
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL11
QuantiTect SYBR Green Assays in human, mouse, rat IL11
QuantiFast Probe-based Assays in human, mouse, rat IL11
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL11

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for IL11 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il111 , 5 interleukin 111, 5 82.91(n)1
87.94(a)1
  7 (2.76 cM)5
161561  NM_008350.41  NP_032376.11 
 47730555 
lizard
(Anolis carolinensis)
Reptilia IL116
interleukin 11
43(a)
1 ↔ 1
GL343279.1(1293779-1296637)


ENSEMBL Gene Tree for IL11 (if available)
TreeFam Gene Tree for IL11 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for IL11 (see all 167)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs42525611,2
C,F,A,H--55876654(-) tgcaaC/Gctcca 2 -- ut31 ese36Minor allele frequency- G:0.22NS NA 100
rs42395921,2
C,F,H--55876667(-) AATCTA/GAGGTC 2 -- ut31 ese313Minor allele frequency- G:0.07NS NA WA CSA EA 348
rs104249561,2
A--55876676(+) ttgccA/Tcactg 2 -- ut31 ese30--------
rs19026081,2
C,F,A,H--55876732(+) ACAAAC/AGGCCC 2 -- ut3114Minor allele frequency- A:0.06NS NA WA CSA EA 468
rs42395931,2
C,F,A--55876747(-) GCCCCG/ACACTG 2 -- ut31 ese37Minor allele frequency- A:0.10NS NA WA CSA 336
rs42525601,2
C,F--55876829(-) CCCGAG/CTGGGC 2 -- ut31 ese35Minor allele frequency- C:0.16NS WA 216
rs42525591,2
C,F,H--55876875(-) ACTGGG/AGCAGG 2 -- ut31 ese315Minor allele frequency- A:0.10NS EA NA WA 1266
rs10425061,2
C,F,O,H--55877111(-) GTCTGT/GCCACA 2 -- ut31 ese328Minor allele frequency- G:0.11NS MN EA NA WA 3412
rs1865264041,2
--55877122(+) TTCTTA/GGAGAC 2 -- ut310--------
rs1907232491,2
--55877138(+) AATCCA/GGGACC 2 -- ut310--------

HapMap Linkage Disequilibrium report for IL11 (55875757 - 55881831 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for IL11 (see all 15):    About this table    
Variant IDTypeSubtypePubMed ID
nsv912466CNV Loss21882294
dgv4017n71CNV Loss21882294
nsv912461CNV Loss21882294
nsv516199CNV Loss19592680
nsv912463CNV Loss21882294
dgv4018n71CNV Loss21882294
nsv912473CNV Loss21882294
nsv912457CNV Loss21882294
dgv4016n71CNV Loss21882294
dgv4019n71CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing IL11
DNA2.0 Custom Variant and Variant Library Synthesis for IL11

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 147681    OMIM disorders: --

6 diseases for IL11:    
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periostitis    hemorrhagic cystitis    osteitis fibrosa    dengue disease
endometriosis    osteoporosis

1 disease from the University of Copenhagen DISEASES database for IL11:
Thrombocytopenia

Find genes that share disorders with IL11           About GenesLikeMe

Selected Novoseek inferred disease relationships for IL11 gene (see all 92)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia 75.7 215 8145045 (2), 9182920 (2), 19647472 (2), 8601708 (2) (see all 99)
thrombocytopenia 73.1 131 18629842 (5), 8896400 (4), 15120938 (3), 9474925 (3) (see all 75)
plasmacytoma 60.2 12 1532843 (3), 7494003 (1), 1450406 (1), 8145046 (1) (see all 9)
thrombocytosis 59.3 8 11843834 (1), 15543003 (1), 7689197 (1), 12478901 (1) (see all 6)
necrosis 58.2 94 11675407 (3), 10022397 (2), 15543003 (2), 9811056 (2) (see all 76)
myeloma 54 35 10572104 (4), 15377473 (3), 1532843 (3), 7647014 (2) (see all 17)
osteolytic 52.1 15 9488033 (2), 11410329 (1), 14600590 (1), 10652584 (1) (see all 12)
mucositis 51.6 18 10899677 (3), 10360368 (2), 9245489 (2), 11045187 (1) (see all 8)
response acute phase 51.1 8 1281789 (1), 12773095 (1), 9876901 (1), 9416001 (1) (see all 6)
inflammatory bowel diseases 50.6 10 10950118 (1), 15992047 (1), 16292518 (1), 9881950 (1) (see all 7)

Genetic Association Database (GAD): IL11
Human Genome Epidemiology (HuGE) Navigator: IL11 (10 documents)

Export disorders for IL11 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for IL11 gene, integrated from 10 sources (see all 935):
(articles sorted by number of sources associating them with IL11)
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  1. Genomic sequence and chromosomal location of human interleukin-11 gene (IL11). (PubMed id 1386338)1, 2, 3, 9 McKinley D.... Yang Y.C. (Genomics 1992)
  2. A polymorphism in the IL11 gene is associated with ulcerative colitis. (PubMed id 12486609)1, 4, 9 Klein W....Epplen J.T. (Genes Immun. 2002)
  3. Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. (PubMed id 20360315)1, 4, 9 Uher R....McGuffin P. (Am J Psychiatry 2010)
  4. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
  5. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
  6. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. A promotor polymorphism in the Interleukin 11 gene is associated with chronic obstructive pulmonary disease. (PubMed id 15004839)1, 4 Klein W....Epplen J.T. (Electrophoresis 2004)
  9. Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11. (PubMed id 1828438)1, 2 Kawashima I.... Takiguchi Y. (FEBS Lett. 1991)
  10. Molecular cloning of a cDNA encoding interleukin 11, a stromal cell- derived lymphopoietic and hematopoietic cytokine. (PubMed id 2145578)1, 2 Paul S.R....Yang Y.-C. (Proc. Natl. Acad. Sci. U.S.A. 1990)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
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  Query String
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OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3589 HGNC: 5966 AceView: IL11 Ensembl:ENSG00000095752 euGenes: HUgn3589
ECgene: IL11 Kegg: 3589 H-InvDB: IL11

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for IL11 Pharmacogenomics, SNPs, Pathways
Neumegahttp://www.drugs.com/cdi/neumega.html
Wikipedia http://en.wikipedia.org/wiki/Interleukin_11
SeattleSNPshttp://pga.gs.washington.edu/data/il11/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IL11 gene:
Search GeneIP for patents involving IL11

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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