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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL11 Gene

protein-coding GIFtS: 64
GCID: GC19M055875

interleukin 11

Explore 130 diseases affiliated with
IL11 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin 11¹ ²		Interleukin-11¹
AGIF¹ ² ³		Oprelvekin³
IL-11¹ ² ³		Oprelvekin³
Adipogenesis Inhibitory Factor² ³

External Ids:	HGNC: 5966¹	Entrez Gene: 3589²	Ensembl: ENSG00000095752⁷	OMIM: 147681⁵	UniProtKB: P20809³

Export aliases for IL11 gene to outside databases

Previous GC identifers: GC19M056740 GC19M056300 GC19M060551 GC19M060567 GC19M052197

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL11:

The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of

multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor

IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B

cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells.

Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. (provided by

RefSeq, Jun 2012)

UniProtKB/Swiss-Prot: IL11_HUMAN, P20809

Function: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and

induces megakaryocyte maturation resulting in increased platelet production

Gene Wiki entry for IL11 (Interleukin 11)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL11 gene promoter:
NF-1 Pax-5 AML1a STAT5A HEN1 PPAR-gamma1 STAT3 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): IL11 promoter sequence

Search SABiosciences Chromatin IP Primers for IL11

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3-q13.4 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.3-q13.4

IL11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL11 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M055875: view genomic region (about GC identifiers)

Start:	55,875,757 bp from pter	End:	55,881,831 bp from pter
Size:	6,075 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL11_HUMAN, P20809 (See protein sequence)

Recommended Name: Interleukin-11 precursor

Size: 199 amino acids; 21429 Da

Subcellular location: Secreted

Secondary accessions: Q96EB4

Explore the universe of human proteins at neXtProt for IL11: NX_P20809

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P20809

IL11 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000632.1 NP_001254647.1

ENSEMBL proteins:

ENSP00000264563 ENSP00000465705 ENSP00000467355 ENSP00000468663

Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant IL11 Protein
	R&D Systems Recombinant & Natural Proteins for IL11 (IL-11)
	Browse recombinant and purified proteins available from Enzo Life Sciences
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	GenScript Purified and Recombinant Proteins for IL11
	Novus Biologicals IL11 Proteins Novus Biologicals IL11 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IL11
	Uscn Proteins for IL11

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IC	2145578
GO:0005615	extracellular space	IEA	--
GO:0005737	cytoplasm	IEA	--

IL11 for ontologies About GeneDecksing

IL11 Antibody Products:

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	R&D Systems Antibodies for IL11 (IL-11)
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	Novus Biologicals IL11 Antibodies
	Search for Antibodies for IL11 at Abcam
	Uscn Antibodies for IL11
	ThermoFisher Antibodies for IL11

Assay Products for IL11:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for IL11 (IL-11)
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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IL11

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL11 for domains About GeneDecksing

3 InterPro domains/families:

IPR009079 4_helix_cytokine-like_core

IPR020412 Interleukin-11_mammalian

IPR020438 Interleukin-11

Graphical View of Domain Structure for InterPro Entry P20809

ProtoNet protein and cluster: P20809

UniProtKB/Swiss-Prot: IL11_HUMAN, P20809

Similarity: Belongs to the IL-6 superfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IL11_HUMAN, P20809

Function: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and

induces megakaryocyte maturation resulting in increased platelet production

Genatlas biochemistry entry for IL11:

interleukin 11,40kDa,interleukin-6 cytokine family member,stimulating the proliferation of B cells,T cell dependent

miRNA Products:		miRTarBase miRNAs that target IL11: hsa-mir-204 (MIRT005829)

		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL11
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate IL11 (see all 26):
		hsa-miR-548j hsa-miR-3910 hsa-miR-548i hsa-miR-124 hsa-miR-149 hsa-miR-23a hsa-miR-548a-5p hsa-miR-548d-5p

		SwitchGear 3'UTR luciferase reporter plasmid: IL11 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL11 (see all 7) OriGene shRNA RFP: IL11 OriGene siRNA: IL11
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL11

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IL11

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL11 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL11 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL11 (NM_000641)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL11

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL11
		Search LifeMap BioReagents cell lines for IL11

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL11

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005142	interleukin-11 receptor binding	NAS	2145578
GO:0008083	growth factor activity	IDA	2145578

IL11 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for IL11:

Increased cell death HMECs cel

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/12 pathways (see all 12)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

TGF-Beta Pathway

TGF-Beta Pathway	1.00	Regulation of eIF4 and p70S6K	0.43
MAPK Family Pathway	0.60	SOCS Pathway	0.29
JAK-STAT Pathway	0.57

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

1.00

Immune response_TLR signaling pathways

0.94

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for IL11

Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

5/26 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL11 (see all 26)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	Signaling Involved in Cardiac Hypertrophy

1 GeneGo (Thomson Reuters) Pathway for IL11

Immune response TLR signaling pathways

3 BioSystems Pathways for IL11

	Integrated Pancreatic Cancer Pathway
	Interleukin-11 Signaling Pathway
	Integrated Pancreatic Cancer Pathway

4 Kegg Pathways (Kegg details for IL11):

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway
	Hematopoietic cell lineage
	Rheumatoid arthritis

IL11 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL11

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for IL11 (P20809^{2, 3} ENSP00000264563⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAGEA11	P43364²^,³, ENSP00000347358⁴	MINT-68236 I2D: score=6 STRING: ENSP00000347358
IL6ST	P40189³, ENSP00000338799⁴	I2D: score=1 STRING: ENSP00000338799
IL11RA	Q14626³, ENSP00000326500⁴	I2D: score=3 STRING: ENSP00000326500

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007267	cell-cell signaling	IC	2145578
GO:0008284	positive regulation of cell proliferation	IDA	2145578
GO:0030168	platelet activation	NAS	--
GO:0030183	B cell differentiation	NAS	2145578
GO:0030219	megakaryocyte differentiation	NAS	2145578

IL11 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL11 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for IL11

Browse Tocris compounds for IL11
UniProtKB/Swiss-Prot: IL11_HUMAN, P20809

Pharmaceutical: Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the

reduction of the need for platelet transfusion following myelosuppressive chemotherapy

10/91 Novoseek chemical compound relationships for IL11 gene (see all 91) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
il 11	95.1	129	12005542 (10), 20074812 (8), 1386338 (6), 19144959 (6) (see all 30)
gp 130	91.2	136	10948192 (7), 9560294 (5), 10692570 (4), 8940087 (3) (see all 72)
cdp571	75.5	1	16985094 (1)
pixy321	63.5	4	7527667 (1), 9922079 (1), 8692093 (1), 7535842 (1)
rantes	49.5	13	10366103 (2), 12620497 (2), 15025215 (2), 9764576 (1) (see all 10)
methylcellulose	49.4	2	9216732 (1)
gm-csf	36	2	9876771 (1), 18086169 (1)
infliximab	34	1	12501498 (1)
tyrosine	33.7	30	8174677 (5), 8360477 (2), 8398901 (2), 10725745 (2) (see all 14)
etanercept	29.1	1	16985094 (1)

Search CenterWatch for drugs/clinical trials and news about IL11

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL11 gene (2 alternative transcripts):

NM_000641.3 NM_001267718.1

Unigene Cluster for IL11:

Interleukin 11

Hs.467304 [show with all ESTs]

Unigene Representative Sequence: NM_000641

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000264563(uc002qks.1 uc010yfx.1) ENST00000590625 ENST00000585513

ENST00000587093

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL11
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate IL11 (see all 26):
		hsa-miR-548j hsa-miR-3910 hsa-miR-548i hsa-miR-124 hsa-miR-149 hsa-miR-23a hsa-miR-548a-5p hsa-miR-548d-5p

		SwitchGear 3'UTR luciferase reporter plasmid: IL11 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL11 (see all 7) OriGene shRNA RFP: IL11 OriGene siRNA: IL11
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL11

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL11 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL11 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL11 (NM_000641)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL11
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL11

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL11 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL11
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL11
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL11

Additional cDNA sequence:

AK290572.1 AK298973.1 AK315294.1 BC012506.1 M57765.1 X58377.1

2 DOTS entries:

DT.95254878 DT.102821513

24/36 AceView cDNA sequences (see all 36):

BF056320 M57765 NM_000641 AI744579 BQ102335 AI620537 BV202913 CK822837

AI073648 AI128942 BF055151 AI148233 AI079412 X58377 CA444136 BX103627

N95545 BQ102222 BC012506 BF439402 T29611 BQ102482 AI095314 AW779662

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACACATTTTA

About this image

IL11 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IL11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL11

SOURCE GeneReport for Unigene cluster: Hs.467304

SABiosciences Expression via Pathway-Focused PCR Arrays including IL11 (see all 8):

Growth Factors in human mouse rat

T-cell & B-cell Activation in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Endothelial Cell Biology in human mouse rat

Inflammatory Cytokines & Receptors in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL11 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL11
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL11
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL11

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL11

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL11 gene from 3/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Il11^{1 , 5}	interleukin 11^{1, 5}	82.91(n)¹ 87.94(a)¹		7 (2.76 cM)⁵ 16156¹ NM_008350.4¹ NP_032376.1¹ 4773055⁵
lizard (Anolis carolinensis)	Reptilia	IL11⁶	--	44(a)	1 ↔ 1	GL343279.1(1293779-1296637)
zebrafish (Danio rerio)	Actinopterygii	il11b⁶ il11a⁶	interleukin 11a	23(a) 22(a)	many → 1 many → 1	19(11052346-11054670) 16(14359727-14366281)

ENSEMBL Gene Tree for IL11 (if available)
TreeFam Gene Tree for IL11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138669230^1,2		--	55875282(+)	`CCAACC/GCCAGA`	3	--	ds500¹ us2k¹		0	--	--	--	--
rs4252564^1,2	C,F,H,	--	55875419(-)	`AAGGAT/CTTGGG`	3	--	us2k¹ ds500¹		13		NS EA WA	1274
rs143577315^1,2		--	55875570(+)	`CAACAC/GAGTCC`	3	--	ds500¹ us2k¹		0	--	--	--	--
rs147986301^1,2		--	55875696(+)	`ATCAGC/TGGTCA`	3	--	ds500¹ us2k¹		0	--	--	--	--
rs184375712^1,2		--	55875743(+)	`AGGAGG/TCTGAT`	3	--	ds500¹ us2k¹		0	--	--	--	--
rs189230995^1,2		--	55875744(+)	`GGAGGC/TTGATA`	3	--	us2k¹ ds500¹		0	--	--	--	--
rs142337805^1,2		--	55876068(+)	`AGGCCA/GGTCTC`	3	--	us2k¹ ut3¹		0	--	--	--	--
rs1126760^1,2	C,F,H,	--	55876074(-)	`GAGTTT/CGAGAC`	3	--	ut3¹ us2k¹		25		NS EA NA WA CSA	1535
rs4252562^1,2	C,F,H,	--	55876162(-)	`GATATC/ACTGAC`	3	--	ut3¹ us2k¹ ese³		13		NS CSA WA NA	1800
rs2298885^1,2	C,F,	--	55876240(-)	`AGAACG/ACCACC`	3	--	ut3¹ us2k¹ ese³		17		NS NA CSA WA EA	1115

HapMap Linkage Disequilibrium report for IL11 (55875757 - 55881831 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for IL11
2 CNVs: 30085 50228

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL11

DNA2.0 Custom Variant and Variant Library Synthesis for IL11

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL11 for disorders           About GeneDecksing

OMIM gene information: 147681    OMIM disorders: --

20/130 diseases for IL11 (see all 130):    About MalaCards

graft versus host disease von willebrand's disease langerhans-cell histiocytosis disseminated intravascular coagulation

osteitis fibrosa osteoporosis, postmenopausal wiskott-aldrich syndrome inflammatory bowel disease 21

inflammatory bowel disease clostridium difficile pre-eclampsia status epilepticus

iron deficiency anemia polycythemia vera myeloid leukemia megakaryoblastic leukemia

spontaneous abortion myeloproliferative disorder chronic obstructive pulmonary disease erythrocytosis

3 diseases from the University of Copenhagen DISEASES database for IL11:

Thrombocytopenia Myeloma Inflammatory bowel disease

10/92 Novoseek disease relationships for IL11 gene (see all 92) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia	75.7	215	8145045 (2), 9182920 (2), 19647472 (2), 8601708 (2) (see all 99)
thrombocytopenia	73.1	131	18629842 (5), 8896400 (4), 15120938 (3), 9474925 (3) (see all 75)
plasmacytoma	60.2	12	1532843 (3), 7494003 (1), 1450406 (1), 8145046 (1) (see all 9)
thrombocytosis	59.3	8	11843834 (1), 15543003 (1), 7689197 (1), 12478901 (1) (see all 6)
necrosis	58.2	94	11675407 (3), 10022397 (2), 15543003 (2), 9811056 (2) (see all 76)
myeloma	54	35	10572104 (4), 15377473 (3), 1532843 (3), 7647014 (2) (see all 17)
osteolytic	52.1	15	9488033 (2), 11410329 (1), 14600590 (1), 10652584 (1) (see all 12)
mucositis	51.6	18	10899677 (3), 10360368 (2), 9245489 (2), 11045187 (1) (see all 8)
response acute phase	51.1	8	1281789 (1), 12773095 (1), 9876901 (1), 9416001 (1) (see all 6)
inflammatory bowel diseases	50.6	10	10950118 (1), 15992047 (1), 16292518 (1), 9881950 (1) (see all 7)

Genetic Association Database (GAD): IL11
Human Genome Epidemiology (HuGE) Navigator: IL11 (10 documents)

Export disorders for IL11 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for IL11 gene, integrated from 9 sources (see all 920):
(articles sorted by number of sources associating them with IL11)

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Genomic sequence and chromosomal location of human interleukin-11 gene (IL11). (PubMed id 1386338)^{1, 2, 3, 9} McKinley D.... Yang Y.C. (1992)
A polymorphism in the IL11 gene is associated with ulcerative colitis. (PubMed id 12486609)^{1, 4, 9} Klein W....Epplen J.T. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A promotor polymorphism in the Interleukin 11 gene is associated with chronic obstructive pulmonary disease. (PubMed id 15004839)^{1, 4} Klein W....Epplen J.T. (2004)
Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11. (PubMed id 1828438)^{1, 2} Kawashima I.... Takiguchi Y. (1991)
Molecular cloning of a cDNA encoding interleukin 11, a stromal cell- derived lymphopoietic and hematopoietic cytokine. (PubMed id 2145578)^{1, 2} Paul S.R....Yang Y.-C. (1990)
Relaxin and prostaglandin E(2) regulate interleukin 11 during human endometrial stromal cell decidualization. (PubMed id 15784719)^{1, 9} Dimitriadis E....Salamonsen L.A. (2005)
Analysis of systemic interleukin-11 after major trauma. (PubMed id 15614128)^{1, 9} Schinkel C....Koller M. (2005)
Interleukin-11 in endometrial adenocarcinoma is regul ated by prostaglandin F2alpha-F-prostanoid receptor interaction via the calcium -calcineurin-nuclear factor of activated T cells pathway and negatively regulat ed by the regulator of calcineurin-1. (PubMed id 20008143)^{1, 9} Sales K.J....Jabbour H.N. (2010)
Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the invasive activity of human gastric carcinoma cells. (PubMed id 17332920)^{1, 9} Nakayama T....Sekin I. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3589	HGNC: 5966	AceView: IL11	Ensembl:ENSG00000095752	euGenes: HUgn3589
ECgene: IL11	Kegg: 3589	H-InvDB: IL11

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for IL11	Pharmacogenomics, SNPs, Pathways
Neumega	http://www.drugs.com/cdi/neumega.html
Wikipedia	http://en.wikipedia.org/wiki/Interleukin_11
SeattleSNPs	http://pga.gs.washington.edu/data/il11/

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Patent Information for IL11 gene:
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interleukin 11

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