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Aliases for IL11 Gene

Aliases for IL11 Gene

  • Interleukin 11 2 3
  • Adipogenesis Inhibitory Factor 2 3 4
  • Oprelvekin 2 3 4
  • IL-11 3 4
  • AGIF 3 4
  • Interleukin-11 3

External Ids for IL11 Gene

Previous GeneCards Identifiers for IL11 Gene

  • GC19M056740
  • GC19M056300
  • GC19M060551
  • GC19M060567
  • GC19M055875
  • GC19M052197

Summaries for IL11 Gene

Entrez Gene Summary for IL11 Gene

  • The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

GeneCards Summary for IL11 Gene

IL11 (Interleukin 11) is a Protein Coding gene. Diseases associated with IL11 include hemorrhagic cystitis and periostitis. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and interleukin-11 receptor binding.

UniProtKB/Swiss-Prot for IL11 Gene

  • Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.

Gene Wiki entry for IL11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL11 Gene

Genomics for IL11 Gene

Regulatory Elements for IL11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IL11 Gene

Start:
55,364,382 bp from pter
End:
55,370,463 bp from pter
Size:
6,082 bases
Orientation:
Minus strand

Genomic View for IL11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL11 Gene

Proteins for IL11 Gene

  • Protein details for IL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20809-IL11_HUMAN
    Recommended name:
    Interleukin-11
    Protein Accession:
    P20809
    Secondary Accessions:
    • B4DQV5
    • Q96EB4

    Protein attributes for IL11 Gene

    Size:
    199 amino acids
    Molecular mass:
    21429 Da
    Quaternary structure:
    • Interacts with IL6ST and either IL11RA1 or IL11RA2, giving rise to a multimeric signaling complex.

    Three dimensional structures from OCA and Proteopedia for IL11 Gene

    Alternative splice isoforms for IL11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL11 Gene

Proteomics data for IL11 Gene at MOPED

Post-translational modifications for IL11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL11 Gene

Antibody Products

Protein Products

No data available for DME Specific Peptides for IL11 Gene

Domains for IL11 Gene

Gene Families for IL11 Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • IL :Interleukins and interleukin receptors

Protein Domains for IL11 Gene

Suggested Antigen Peptide Sequences for IL11 Gene

Graphical View of Domain Structure for InterPro Entry

P20809

UniProtKB/Swiss-Prot:

IL11_HUMAN :
  • P20809
Family:
  • Belongs to the IL-6 superfamily.
genes like me logo Genes that share domains with IL11: view

Function for IL11 Gene

Molecular function for IL11 Gene

GENATLAS Biochemistry:
interleukin 11,40kDa,interleukin-6 cytokine family member,stimulating the proliferation of B cells,T cell dependent
UniProtKB/Swiss-Prot Function:
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.

Gene Ontology (GO) - Molecular Function for IL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005142 interleukin-11 receptor binding NAS 2145578
GO:0005515 protein binding IPI 25416956
GO:0008083 growth factor activity IDA 2145578
genes like me logo Genes that share ontologies with IL11: view

Phenotypes for IL11 Gene

GenomeRNAi human phenotypes for IL11:
genes like me logo Genes that share phenotypes with IL11: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IL11 Gene

Localization for IL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL11 Gene COMPARTMENTS Subcellular localization image for IL11 gene
Compartment Confidence
extracellular 5
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IC 2145578
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IL11: view

Pathways for IL11 Gene

genes like me logo Genes that share pathways with IL11: view

PCR Array Products

Gene Ontology (GO) - Biological Process for IL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling IC 2145578
GO:0008284 positive regulation of cell proliferation IDA 2145578
GO:0030183 B cell differentiation NAS 2145578
GO:0030219 megakaryocyte differentiation NAS 2145578
GO:0033138 positive regulation of peptidyl-serine phosphorylation IDA 7508917
genes like me logo Genes that share ontologies with IL11: view

Compounds for IL11 Gene

UniProtKB/Swiss-Prot:

P20809-IL11_HUMAN
Pharmaceutical: Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy

(91) Novoseek inferred chemical compound relationships for IL11 Gene

Compound -log(P) Hits PubMed IDs
il 11 95.1 76
gp 130 91.2 104
cdp571 75.5 1
pixy321 63.5 4
rantes 49.5 13
genes like me logo Genes that share compounds with IL11: view

Transcripts for IL11 Gene

Unigene Clusters for IL11 Gene

Interleukin 11:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL11 Gene

No ASD Table

Relevant External Links for IL11 Gene

GeneLoc Exon Structure for
IL11
ECgene alternative splicing isoforms for
IL11

Expression for IL11 Gene

mRNA expression in normal human tissues for IL11 Gene

mRNA differential expression in normal tissues according to GTEx for IL11 Gene

This gene is overexpressed in Prostate (7.1), Pituitary (5.9), Brain - Cerebellum (5.7), Brain - Cerebellar Hemisphere (5.0), and Kidney - Cortex (5.0).

Protein differential expression in normal tissues for IL11 Gene

This gene is overexpressed in Skin (53.3) and Islet of Langerhans (15.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL11 Gene

SOURCE GeneReport for Unigene cluster for IL11 Gene Hs.467304

genes like me logo Genes that share expressions with IL11: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IL11 Gene

Orthologs for IL11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL11 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia IL11 35
  • 87.41 (n)
  • 93.88 (a)
IL11 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il11 35
  • 82.91 (n)
  • 87.94 (a)
Il11 16
Il11 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL11 35
  • 99.5 (n)
  • 100 (a)
IL11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il11 35
  • 82.08 (n)
  • 87.44 (a)
cow
(Bos Taurus)
Mammalia IL11 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL11 36
  • 43 (a)
OneToOne
Species with no ortholog for IL11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL11 Gene

ENSEMBL:
Gene Tree for IL11 (if available)
TreeFam:
Gene Tree for IL11 (if available)

Paralogs for IL11 Gene

No data available for Paralogs for IL11 Gene

Variants for IL11 Gene

Sequence variations from dbSNP and Humsavar for IL11 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1042505 -- 55,365,863(-) GGGGG(A/G)CATCT utr-variant-3-prime
rs1042506 -- 55,365,743(-) GTCTG(G/T)CCACA utr-variant-3-prime
rs1126757 -- 55,368,504(-) AGTGC(A/G)GGGGC synonymous-codon, reference
rs1902608 -- 55,365,364(+) ACAAA(A/C)GGCCC utr-variant-3-prime
rs3761106 -- 55,369,112(+) ggcct(C/G)ggggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL11 Gene

Variant ID Type Subtype PubMed ID
dgv4016n71 CNV Loss 21882294
nsv912457 CNV Loss 21882294
nsv912460 CNV Loss 21882294
nsv912461 CNV Loss 21882294
nsv470162 CNV Loss 18288195
dgv4017n71 CNV Loss 21882294
nsv912463 CNV Loss 21882294
nsv516199 CNV Loss 19592680
nsv912466 CNV Loss 21882294
nsv912467 CNV Loss 21882294
dgv4018n71 CNV Loss 21882294
dgv4019n71 CNV Loss 21882294
dgv4020n71 CNV Loss 21882294
nsv912471 CNV Loss 21882294
nsv912473 CNV Loss 21882294

Relevant External Links for IL11 Gene

HapMap Linkage Disequilibrium report
IL11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL11 Gene

Disorders for IL11 Gene

(1) University of Copenhagen DISEASES for IL11 Gene

(92) Novoseek inferred disease relationships for IL11 Gene

Disease -log(P) Hits PubMed IDs
leukemia 75.7 115
thrombocytopenia 73.1 106
plasmacytoma 60.2 11
thrombocytosis 59.3 6
necrosis 58.2 81

Relevant External Links for IL11

Genetic Association Database (GAD)
IL11
Human Genome Epidemiology (HuGE) Navigator
IL11
genes like me logo Genes that share disorders with IL11: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for IL11 Gene

Publications for IL11 Gene

  1. Genomic sequence and chromosomal location of human interleukin-11 gene (IL11). (PMID: 1386338) McKinley D. … Yang Y.C. (Genomics 1992) 2 3 4 23
  2. A polymorphism in the IL11 gene is associated with ulcerative colitis. (PMID: 12486609) Klein W. … Epplen J.T. (Genes Immun. 2002) 3 23 48
  3. Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. (PMID: 20360315) Uher R. … McGuffin P. (Am J Psychiatry 2010) 3 23 48
  4. Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11. (PMID: 1828438) Kawashima I. … Takiguchi Y. (FEBS Lett. 1991) 3 4
  5. Molecular cloning of a cDNA encoding interleukin 11, a stromal cell- derived lymphopoietic and hematopoietic cytokine. (PMID: 2145578) Paul S.R. … Yang Y.-C. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 4

Products for IL11 Gene

Sources for IL11 Gene

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