Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IL10RB Gene

Aliases for IL10RB Gene

  • Interleukin 10 Receptor Subunit Beta 2 3 5
  • Cytokine Receptor Class-II Member 4 3 4
  • Cytokine Receptor Family 2 Member 4 3 4
  • Interleukin-10 Receptor Subunit 2 3 4
  • Interleukin 10 Receptor, Beta 2 3
  • IL-10 Receptor Subunit Beta 3 4
  • IL-10R Subunit Beta 3 4
  • IL-10R Subunit 2 3 4
  • IL-10R2 3 4
  • IL-10RB 3 4
  • D21S58 3 4
  • D21S66 3 4
  • CRF2-4 3 4
  • CRFB4 3 4
  • Cytokine Receptor Family II, Member 4 3
  • Interleukin-10 Receptor Subunit Beta 3
  • Cytokine Receptor Class-II CRF2-4 3
  • CDw210b Antigen 4
  • CDW210B 3

External Ids for IL10RB Gene

Previous HGNC Symbols for IL10RB Gene

  • CRFB4
  • D21S58
  • D21S66

Previous GeneCards Identifiers for IL10RB Gene

  • GC21P031216
  • GC21P033556
  • GC21P033559
  • GC21P033560
  • GC21P034638
  • GC21P020104

Summaries for IL10RB Gene

Entrez Gene Summary for IL10RB Gene

  • The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL10RB Gene

IL10RB (Interleukin 10 Receptor Subunit Beta) is a Protein Coding gene. Diseases associated with IL10RB include Inflammatory Bowel Disease 25, Early Onset, Autosomal Recessive and Colitis. Among its related pathways are Immune System and Jak/STAT Signaling Pathway. GO annotations related to this gene include receptor activity and interleukin-10 receptor activity. An important paralog of this gene is ENSG00000249624.

UniProtKB/Swiss-Prot for IL10RB Gene

  • Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.

Gene Wiki entry for IL10RB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL10RB Gene

Genomics for IL10RB Gene

Regulatory Elements for IL10RB Gene

Enhancers for IL10RB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21F033298 1.1 FANTOM5 Ensembl ENCODE 18.4 +35.7 35743 7.4 PKNOX1 ATF1 YY1 ELK1 GATA2 ZNF143 KLF13 PPARG TBX21 CREB3 IFNAR1 IFNAR2 IL10RB IFNGR2 ENSG00000249624 GART TMEM50B URB1 SON OLIG1
GH21F033246 0.8 ENCODE 15.3 -18.6 -18608 2.1 NR2F1 NR2F6 MNT IL10RB IFNAR2 ENSG00000249624 IL10RB-AS1
GH21F033259 1 Ensembl ENCODE 15.2 -5.6 -5615 2.9 SCRT1 SAP130 NRF1 BHLHE40 ARID4B MAX BRF2 RAD21 SCRT2 FOS IL10RB IFNAR2 DNAJC28 BTF3P6 IL10RB-AS1 ENSG00000249624
GH21F033243 0.8 ENCODE 14.8 -21.7 -21698 2.1 PKNOX1 SAP130 CHD7 THRB RAD21 KAT2B YY1 ZNF335 SCRT2 HNF4G IL10RB IFNAR2 ENSG00000249624
GH21F033264 1 Ensembl ENCODE 13.9 +1.6 1635 6.6 PKNOX1 CREB3L1 WRNIP1 ZFP64 SIN3A YBX1 ZNF766 FOS KLF13 SP3 IL10RB IFNAR2 IL10RB-AS1 IFNAR1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IL10RB on UCSC Golden Path with GeneCards custom track

Promoters for IL10RB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001566313 242 2001 WRNIP1 ZFP64 SIN3A ZNF48 GLIS2 ELK1 KLF13 SP3 JUNB REST

Genomic Location for IL10RB Gene

Chromosome:
21
Start:
33,266,358 bp from pter
End:
33,310,187 bp from pter
Size:
43,830 bases
Orientation:
Plus strand

Genomic View for IL10RB Gene

Genes around IL10RB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL10RB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL10RB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL10RB Gene

Proteins for IL10RB Gene

  • Protein details for IL10RB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08334-I10R2_HUMAN
    Recommended name:
    Interleukin-10 receptor subunit beta
    Protein Accession:
    Q08334
    Secondary Accessions:
    • Q9BUU4

    Protein attributes for IL10RB Gene

    Size:
    325 amino acids
    Molecular mass:
    36995 Da
    Quaternary structure:
    • Heterodimer with IFNLR1.

    Three dimensional structures from OCA and Proteopedia for IL10RB Gene

neXtProt entry for IL10RB Gene

Post-translational modifications for IL10RB Gene

  • Glycosylation at Asn 49, Asn 68, Asn 102, and Asn 161
  • Modification sites at PhosphoSitePlus

Other Protein References for IL10RB Gene

Antibody Products

  • R&D Systems Antibodies for IL10RB (IL-10 R beta)
  • Cloud-Clone Corp. Antibodies for IL10RB

No data available for DME Specific Peptides for IL10RB Gene

Domains & Families for IL10RB Gene

Protein Domains for IL10RB Gene

Suggested Antigen Peptide Sequences for IL10RB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08334

UniProtKB/Swiss-Prot:

I10R2_HUMAN :
  • Contains 2 fibronectin type-III domains.
  • Belongs to the type II cytokine receptor family.
Domain:
  • Contains 2 fibronectin type-III domains.
Family:
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IL10RB: view

Function for IL10RB Gene

Molecular function for IL10RB Gene

GENATLAS Biochemistry:
interleukin 10,receptor beta,cytokine receptor family II,member 4 (CRF2-4)
UniProtKB/Swiss-Prot Function:
Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.

Gene Ontology (GO) - Molecular Function for IL10RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 8314576
GO:0004920 contributes_to interleukin-10 receptor activity TAS 10954742
GO:0005515 protein binding IPI 12483210
genes like me logo Genes that share ontologies with IL10RB: view
genes like me logo Genes that share phenotypes with IL10RB: view

Human Phenotype Ontology for IL10RB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL10RB Gene

MGI Knock Outs for IL10RB:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL10RB Gene

Localization for IL10RB Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL10RB Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL10RB Gene COMPARTMENTS Subcellular localization image for IL10RB gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL10RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS 9312047
GO:0032002 interleukin-28 receptor complex NAS 12483210
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with IL10RB: view

Pathways & Interactions for IL10RB Gene

genes like me logo Genes that share pathways with IL10RB: view

SIGNOR curated interactions for IL10RB Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL10RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 10954742
GO:0006955 immune response TAS 9463407
GO:0007165 signal transduction TAS 10954742
GO:0019221 cytokine-mediated signaling pathway IEA --
GO:0051607 defense response to virus IEA --
genes like me logo Genes that share ontologies with IL10RB: view

Drugs & Compounds for IL10RB Gene

(4) Drugs for IL10RB Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
IFN-Λ1 Pharma 0
IFN-Λ2 Pharma 0
IFN-Λ3 Pharma 0
PEG-INTERFERON LAMBA Pharma 0
genes like me logo Genes that share compounds with IL10RB: view

Transcripts for IL10RB Gene

Unigene Clusters for IL10RB Gene

Interleukin 10 receptor, beta:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL10RB Gene

No ASD Table

Relevant External Links for IL10RB Gene

GeneLoc Exon Structure for
IL10RB
ECgene alternative splicing isoforms for
IL10RB

Expression for IL10RB Gene

mRNA expression in normal human tissues for IL10RB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL10RB Gene

This gene is overexpressed in Whole Blood (x11.5).

Protein differential expression in normal tissues from HIPED for IL10RB Gene

This gene is overexpressed in Neutrophil (60.0) and Urine (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL10RB Gene



Protein tissue co-expression partners for IL10RB Gene

NURSA nuclear receptor signaling pathways regulating expression of IL10RB Gene:

IL10RB

SOURCE GeneReport for Unigene cluster for IL10RB Gene:

Hs.654593
genes like me logo Genes that share expression patterns with IL10RB: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for IL10RB Gene

Orthologs for IL10RB Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL10RB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL10RB 34
  • 99.59 (n)
-- 35
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia IL10RB 34 35
  • 84.23 (n)
dog
(Canis familiaris)
Mammalia IL10RB 34
  • 83.28 (n)
-- 35
  • 68 (a)
ManyToMany
-- 35
  • 68 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Il10rb 34
  • 76.95 (n)
mouse
(Mus musculus)
Mammalia Il10rb 34 16 35
  • 76.65 (n)
Gm21970 35
  • 50 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 40 (a)
OneToMany
chicken
(Gallus gallus)
Aves IL10RB 34
  • 55.01 (n)
IL10R2 35
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 29 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia il10rb 34
  • 48.83 (n)
zebrafish
(Danio rerio)
Actinopterygii crfb4 34 35
  • 45.26 (n)
crfb15 35 35
  • 25 (a)
ManyToMany
Species where no ortholog for IL10RB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL10RB Gene

ENSEMBL:
Gene Tree for IL10RB (if available)
TreeFam:
Gene Tree for IL10RB (if available)

Paralogs for IL10RB Gene

Paralogs for IL10RB Gene

genes like me logo Genes that share paralogs with IL10RB: view

Variants for IL10RB Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IL10RB Gene

I10R2_HUMAN-Q08334
Genetic variations in IL10RB influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424].

Sequence variations from dbSNP and Humsavar for IL10RB Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs121909601 Pathogenic 33,279,897(+) TACTG(A/G)AAAAA reference, stop-gained
rs387907326 Pathogenic 33,279,841(+) AATAC(A/G/T)AAACT reference, missense, stop-gained
rs2834167 other 33,268,483(+) TTGCC(A/G)AAGGG reference, missense
rs1023146 -- 33,271,917(+) cagcc(C/T)cttgt intron-variant
rs1058857 -- 33,266,477(+) TGGAG(C/T)CTTGG upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for IL10RB Gene

Variant ID Type Subtype PubMed ID
nsv587376 CNV gain 21841781
nsv587377 CNV loss 21841781
nsv587378 CNV gain 21841781

Variation tolerance for IL10RB Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.34; 90.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL10RB Gene

Human Gene Mutation Database (HGMD)
IL10RB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL10RB

Disorders for IL10RB Gene

MalaCards: The human disease database

(7) MalaCards diseases for IL10RB Gene - From: ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease 25, early onset, autosomal recessive
  • autosomal recessive early-onset inflammatory bowel disease
colitis
crohn's disease
  • crohn disease
mumps
rubella
  • german measles
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

I10R2_HUMAN
  • Inflammatory bowel disease 25 (IBD25) [MIM:612567]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269 PubMed:19890111}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IL10RB

Genetic Association Database (GAD)
IL10RB
Human Genome Epidemiology (HuGE) Navigator
IL10RB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL10RB
genes like me logo Genes that share disorders with IL10RB: view

No data available for Genatlas for IL10RB Gene

Publications for IL10RB Gene

  1. A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR. (PMID: 8314576) Lutfalla G. … Uze G. (Genomics 1993) 2 3 4 22 64
  2. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. (PMID: 19890111) Glocker E.O. … Klein C. (N. Engl. J. Med. 2009) 3 4 22 64
  3. Association of IL-10 receptor 2 (IL10RB) SNP with systemic sclerosis. (PMID: 18588853) Hikami K. … Tsuchiya N. (Biochem. Biophys. Res. Commun. 2008) 3 22 46 64
  4. Identification and functional characterization of a second chain of the interleukin-10 receptor complex. (PMID: 9312047) Kotenko S.V. … Pestka S. (EMBO J. 1997) 2 3 4 64
  5. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PMID: 20140262) Ryckman K.K. … Jacobsson B. (PLoS ONE 2010) 3 46 64

Products for IL10RB Gene

Sources for IL10RB Gene

Content
Loading form....