Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IL10RB Gene

protein-coding   GIFtS: 60
GCID: GC21P034638

Interleukin 10 Receptor, Beta


(Previous symbols: CRFB4, D21S58, D21S66)
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

TryGeneCards Plus

Aliases
Interleukin 10 Receptor, Beta1 2     IL-10 Receptor Subunit Beta2 3
CRFB41 2 3 5     IL-10R Subunit 22 3
D21S581 2 3     IL-10R Subunit Beta2 3
D21S661 2 3     Human Transmembrane Receptor Protein; Cytokine Receptor11
Cytokine Receptor Class-II Member 42 3     CDW210B2
Cytokine Receptor Family 2 Member 42 3     Cytokine Receptor Class-II CRF2-42
Interleukin-10 Receptor Subunit 22 3     Cytokine Receptor Family II, Member 42
CRF2-42 3     Interleukin-10 Receptor Subunit Beta2
IL-10R22 3     CDw210b Antigen3
IL-10RB2 3     IBD255

External Ids:    HGNC: 59651   Entrez Gene: 35882   Ensembl: ENSG000002436467   OMIM: 1238895   UniProtKB: Q083343   

Export aliases for IL10RB gene to outside databases

Previous GC identifers: GC21P031216 GC21P033556 GC21P033559 GC21P033560 GC21P020104


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for IL10RB Gene:
The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for
the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be
required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2,
IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21.
(provided by RefSeq, Jul 2008)

GeneCards Summary for IL10RB Gene:
IL10RB (interleukin 10 receptor, beta) is a protein-coding gene. Diseases associated with IL10RB include inflammatory bowel disease 25, autosomal recessive, and inflammatory bowel disease 25, early onset, autosomal recessive. GO annotations related to this gene include receptor activity and interleukin-10 receptor activity. An important paralog of this gene is IFNAR1.

UniProtKB/Swiss-Prot: I10R2_HUMAN, Q08334
Function: Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26,
IL28, and IFNL1

Gene Wiki entry for IL10RB (Interleukin 10 receptor, beta subunit) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000021.9  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL10RB gene promoter:
         NF-YA   NF-YB   CBF-B   CBF-A   HSF2   STAT3   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL10RB promoter sequence

   Search Chromatin IP Primers for IL10RB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL10RB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.11
Nature(405: 311-319) cytogenetic band:   21q22.11
IL10RB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL10RB gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P034638:   GeneLoc Nature:405,311-319
Start:
34,638,663 bp from pter       20,215,375 bp from centromere
End:
34,669,539 bp from pter 20,246,167 bp from centromere
Size:
30,877 bases 30,793 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: Z17227
genomic clones: pS318


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: I10R2_HUMAN, Q08334 (See protein sequence)
Recommended Name: Interleukin-10 receptor subunit beta precursor  
Size: 325 amino acids; 36995 Da
1 PDB 3D structure from and Proteopedia for IL10RB:
3LQM (3D)    
Secondary accessions: Q9BUU4

Explore the universe of human proteins at neXtProt for IL10RB: NX_Q08334

Explore proteomics data for IL10RB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn49, Asn68, Asn102, Asn161
  • Modification sites at PhosphoSitePlus

  • See IL10RB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000619.3  
    ENSEMBL proteins: 
     ENSP00000290200   ENSP00000414682   ENSP00000397611  

    IL10RB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL10RB (IL-10 R beta)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IL10RB
    GenScript Custom Purified and Recombinant Proteins Services for IL10RB
    Novus Biologicals IL10RB Protein
    Novus Biologicals IL10RB Lysates
    Sino Biological Recombinant Protein for IL10RB
    Sino Biological Cell Lysate for IL10RB
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    IL10RB Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for IL10RB (IL-10 R beta)
    OriGene Antibodies for IL10RB
    OriGene Custom Antibody Services for IL10RB
    Novus Biologicals IL10RB Antibodies
    Abcam antibodies for IL10RB
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for IL10RB
    LSBio Antibodies in human, mouse, rat for IL10RB

    IL10RB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL10RB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IL10RB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 10 receptor, beta subunit
    IL-10 receptor family

    3 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR015373 Interferon_alpha/beta_rcpt_bsu
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q08334

    ProtoNet protein and cluster: Q08334

    1 Blocks protein domain: IPB001187 Tissue factor

    UniProtKB/Swiss-Prot: I10R2_HUMAN, Q08334
    Similarity: Belongs to the type II cytokine receptor family
    Similarity: Contains 2 fibronectin type-III domains


    IL10RB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I10R2_HUMAN, Q08334
    Function: Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26,
    IL28, and IFNL1

         Genatlas biochemistry entry for IL10RB:
    interleukin 10,receptor beta,cytokine receptor family II,member 4 (CRF2-4)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS8314576
    GO:0004920contributes to interleukin-10 receptor activity TAS10954742
    GO:0005515protein binding IPI12483210
         
    IL10RB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IL10RB:
     Synthetic lethal with c-Myc af 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Il10rb):
     cellular  digestive/alimentary  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  respiratory system 

    IL10RB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Il10rbtm1Agt for IL10RB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL10RB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL10RB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL10RB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL10RB

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat IL10RB using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate IL10RB:
    hsa-miR-1226 hsa-miR-29c hsa-miR-29a hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidIL10RB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL10RB
    Predesigned siRNA for gene silencing in human, mouse, rat IL10RB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL10RB

    Clone
    Products:
         
    OriGene clones in human, mouse for IL10RB (see all 6)
    OriGene ORF clones in mouse, rat for IL10RB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL10RB (NM_000628)
    Sino Biological Human cDNA Clone for IL10RB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL10RB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL10RB

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL10RB
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL10RB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL10RB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    I10R2_HUMAN, Q08334: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS10954742
    GO:0016021integral component of membrane TAS9312047
    GO:0032002interleukin-28 receptor complex NAS12483210

    IL10RB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for IL10RB About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    PGC1Alpha Pathway0.51
    Glucocorticoid Receptor Signaling0.43
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    2Immune response Antigen presentation by MHC class II
    Immune response IL 22 signaling pathway0.31
    IL-22 Pathway0.00
    3Jak-STAT signaling pathway
    Jak-STAT signaling pathway
    Type III interferon signaling0.00
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51
    5Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL10RB (see all 15)
        THC Differentiation Pathway
    STAT3 Pathway
    IL-10 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    2 GeneGo (Thomson Reuters) Pathways for IL10RB
        Immune response IL-22 signaling pathway
    Immune response IL-10 signaling pathway

    1 BioSystems Pathway for IL10RB
        Type III interferon signaling



    5 Kegg Pathways  (Kegg details for IL10RB):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    Toxoplasmosis
    Tuberculosis
    Epstein-Barr virus infection


    IL10RB for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL10RB: 
              Interferons & Receptors in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL10RB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for IL10RB (Q083343 ENSP000002902004) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL10RAQ136513, ENSP000002277524I2D: score=3 STRING: ENSP00000227752
    IL22Q9GZX63, ENSP000003293844I2D: score=2 STRING: ENSP00000329384
    UCN3Q969E33, ENSP000003697984I2D: score=2 STRING: ENSP00000369798
    IFNL2Q8IZJ03, ENSP000003336394I2D: score=1 STRING: ENSP00000333639
    IL10P223013, ENSP000004122374I2D: score=2 STRING: ENSP00000412237
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response TAS10954742
    GO:0006955immune response TAS9463407
    GO:0007165signal transduction TAS10954742
    GO:0019221cytokine-mediated signaling pathway TAS10954742

    IL10RB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL10RB (I10R2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for IL10RB gene: 
    NM_000628.4  

    Unigene Cluster for IL10RB:

    Interleukin 10 receptor, beta
    Hs.654593  [show with all ESTs]
    Unigene Representative Sequence: AK124057
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290200(uc002yrk.1) ENST00000422891 ENST00000493295(uc002yrl.1)
    ENST00000498371 ENST00000451065

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IL10RB using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate IL10RB:
    hsa-miR-1226 hsa-miR-29c hsa-miR-29a hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidIL10RB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IL10RB
    Predesigned siRNA for gene silencing in human, mouse, rat IL10RB
    Clone
    Products:
         
    OriGene clones in human, mouse for IL10RB (see all 6)
    OriGene ORF clones in mouse, rat for IL10RB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL10RB (NM_000628)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL10RB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL10RB
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IL10RB
    OriGene qSTAR qPCR primer pairs in human, mouse for IL10RB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL10RB
      QuantiTect SYBR Green Assays in human, mouse, rat IL10RB
      QuantiFast Probe-based Assays in human, mouse, rat IL10RB

    Additional mRNA sequence: 

    AK124057.1 AK313348.1 BC001903.1 BT009777.1 DQ655970.2 JN591378.1 Z17227.1 

    13 DOTS entries:

    DT.215104  DT.100782414  DT.100782406  DT.101984320  DT.100782409  DT.40193205  DT.102833517  DT.86843120 
    DT.95276759  DT.121132974  DT.121133032  DT.86852545  DT.92467568 

    Selected AceView cDNA sequences (see all 163):

    BP335128 BQ689476 BM738064 BM763594 CA407122 AI755038 BE876623 AL549087 
    BM755923 BQ064860 BQ929117 AI096666 AL552368 BQ688197 AV650258 CR601076 
    BX399445 AK124057 BM920179 AI440427 AL710018 NM_000628 AA307672 BQ888243 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IL10RB expression in normal human tissues (normalized intensities)      IL10RB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IL10RB Expression
    About this image


    IL10RB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             Thymus
     
     Lung (Respiratory System)
             Trachea
    IL10RB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL10RB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654593
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL10RB: 
              Interferons & Receptors in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IL10RB
    OriGene qSTAR qPCR primer pairs in human, mouse for IL10RB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL10RB
    QuantiTect SYBR Green Assays in human, mouse, rat IL10RB
    QuantiFast Probe-based Assays in human, mouse, rat IL10RB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL10RB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for IL10RB gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il10rb1 , 5 interleukin 10 receptor, beta1, 5 76.65(n)1
    69.44(a)1
      16 (52.87 cM)5
    161551  NM_008349.51  NP_032375.21 
     914061645 
    chicken
    (Gallus gallus)
    Aves IL10RB1 interleukin 10 receptor, beta 55.01(n)
    43.03(a)
      395663  NM_204857.1  NP_990188.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    29(a)
    1 → many
    GL343628.1(263571-293406)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia il10rb1 interleukin 10 receptor, beta 48.83(n)
    35.66(a)
      100329183  NM_001171823.1  NP_001165294.1 
    zebrafish
    (Danio rerio)
    Actinopterygii crfb41 cytokine receptor family member b4 45.26(n)
    30.08(a)
      797527  NM_001083868.1  NP_001077337.1 


    ENSEMBL Gene Tree for IL10RB (if available)
    TreeFam Gene Tree for IL10RB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for IL10RB gene
    IFNAR12  ENSG000002496242  

    IL10RB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    I10R2_HUMAN, Q08334: Genetic variations in IL10RB influence susceptibility to hepatitis B virus (HBV) infection
    [MIM:610424]


    Selected SNPs for IL10RB (see all 832)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs28341671,2,,4
    C,F,O,A,Hother125187649(+) TTGCCA/GAAGGG 2 K E mis139Minor allele frequency- N:0.00NA NS EA MN WA EU 11120
    rs454827981,2
    F--20102837(+) TCCAAG/TATCCT 1 -- us2k11Minor allele frequency- T:0.00MN 538
    rs454475001,2
    C,F--20102906(+) GCAATC/TCTGAG 1 -- us2k11Minor allele frequency- T:0.00MN 540
    rs1434185841,2
    --20103000(+) CTTAGG/TCCCCT 1 -- us2k10--------
    rs178602661,2
    C,F,H--20103004(+) GGCCCC/TTTCAA 1 -- us2k15Minor allele frequency- T:0.00NS NA 358
    rs1483716281,2
    --20103018(+) GGGAAA/GACTAA 1 -- us2k10--------
    rs1822191091,2
    --20103032(+) TTATAC/TAAGTT 1 -- us2k10--------
    rs1142934651,2
    C,F--20103069(+) TTTATA/GTGATT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs81784331,2
    C,F--20103155(+) TATATT/GGAATC 1 -- us2k113Minor allele frequency- G:0.04NS NA CSA 1826
    rs81784341,2
    C,F--20103256(+) TGTGTT/GTGTGT 1 -- us2k15Minor allele frequency- G:0.03NS MN NA 748

    HapMap Linkage Disequilibrium report for IL10RB (34638663 - 34669539 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for IL10RB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv913720CNV Loss21882294
    nsv913716CNV Loss21882294
    nsv913719CNV Loss21882294
    nsv913715CNV Loss21882294
    nsv913717CNV Gain21882294
    nsv913714CNV Gain21882294
    nsv913718CNV Gain21882294

    Human Gene Mutation Database (HGMD): IL10RB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL10RB
    DNA2.0 Custom Variant and Variant Library Synthesis for IL10RB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 123889   
    OMIM disorders: 610424  612567  
    UniProtKB/Swiss-Prot: I10R2_HUMAN, Q08334
  • Inflammatory bowel disease 25 (IBD25) [MIM:612567]: A chronic, relapsing inflammation of the
    gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis
    phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most
    frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may
    contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the
    inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not
    observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • Selected diseases for IL10RB (see all 39):    About MalaCards
    inflammatory bowel disease 25, autosomal recessive    inflammatory bowel disease 25, early onset, autosomal recessive    mumps    cblc
    rubella    inflammatory bowel disease    toxoplasmosis    acute graft versus host disease
    vaccinia    graft versus host disease    measles    vitiligo
    anaplastic large cell lymphoma    hepatitis b    chondrosarcoma    bronchiolitis
    hyperparathyroidism    multiple myeloma    labyrinthitis    ulcerative colitis


    IL10RB for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    2 Novoseek inferred disease relationships for IL10RB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colitis 31.3 2 19890111 (1)
    tumors 0 2 18509351 (1), 20103601 (1)

    Genetic Association Database (GAD): IL10RB
    Human Genome Epidemiology (HuGE) Navigator: IL10RB (28 documents)

    Export disorders for IL10RB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IL10RB gene, integrated from 10 sources (see all 104):
    (articles sorted by number of sources associating them with IL10RB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR. (PubMed id 8314576)1, 2, 3, 9 Lutfalla G.... Uze G. (Genomics 1993)
    2. Identification and functional characterization of a second chain of the interleukin-10 receptor complex. (PubMed id 9312047)1, 2, 3 Kotenko S.V....Pestka S. (EMBO J. 1997)
    3. Association of IL-10 receptor 2 (IL10RB) SNP with systemic sclerosis. (PubMed id 18588853)1, 4, 9 Hikami K....Tsuchiya N. (Biochem. Biophys. Res. Commun. 2008)
    4. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. (PubMed id 19890111)1, 2, 9 Glocker E.O....Klein C. (N. Engl. J. Med. 2009)
    5. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (PLoS ONE 2010)
    6. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    7. Association of candidate susceptible loci with chronic infection with hepatitis B virus in a Chinese population. (PubMed id 20087947)1, 4 Chen D.Q....Zheng B.J. (J. Med. Virol. 2010)
    8. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. (PubMed id 20811626)1, 4 Hildebrandt M.A....Wu X. (PLoS ONE 2010)
    9. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    10. Interleukin-10 (IL-10) pathway: genetic variants and outcomes of HIV-1 infection in African American adolescents. (PubMed id 20976276)1, 4 Shrestha S....Tang J. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3588 HGNC: 5965 AceView: IL10RB Ensembl:ENSG00000243646 euGenes: HUgn3588
    ECgene: IL10RB Kegg: 3588 H-InvDB: IL10RB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IL10RB Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/il10rb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IL10RB gene:
    Search GeneIP for patents involving IL10RB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for IL10RB (IL-10 R beta)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for IL10RB (IL-10 R beta)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for IL10RB   OriGene RNAi products in human, mouse, rat for IL10RB  
     OriGene qPCR primer pairs and template standards for IL10RB   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for IL10RB  
     OriGene qSTAR qPCR primer pairs in human, mouse for IL10RB   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for IL10RB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IL10RB   OriGene Custom Protein Services for IL10RB  

     
     
     Block miRNA regulation of human, mouse, rat IL10RB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IL10RB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL10RB Predesigned siRNA for gene silencing in human, mouse, rat IL10RB
     QuantiFast Probe-based Assays in human, mouse, rat IL10RB QuantiTect SYBR Green Assays in human, mouse, rat IL10RB
     PCR Arrays including human, mouse, rat IL10RB Search Chromatin IP Primers for IL10RB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL10RB  GeneGlobe Interaction Network for IL10RB
     Regulatory tfbs in IL10RB promoter
     GenScript Custom Purified and Recombinant Proteins Services for IL10RB GenScript cDNA clones with any tag delivered in your preferred vector for IL10RB
     GenScript Custom Assay Services for IL10RB GenScript Custom overexpressing Cell Line Services for IL10RB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for IL10RB (I10R2)
     Proteins for IL10RB
     Cell Lysates for IL10RB
     cDNA Clones for IL10RB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IL10RB antibodies
     IL10RB proteins
     IL10RB lysates
     Antibodies for IL10RB
     See all of Abcam's Antibodies, Kits and Proteins for IL10RB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for IL10RB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL10RB
     SwitchGear 3'UTR luciferase reporter plasmids for IL10RB
     SwitchGear Promoter luciferase reporter plasmids for IL10RB
     ThermoFisher Antibodies for IL10RB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL10RB
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL10RB
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL10RB
     LSBio Antibodies in human, mouse, rat for IL10RB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IL10RB gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4