Aliases for IL10RB Gene
External Ids for IL10RB Gene
Previous HGNC Symbols for IL10RB Gene
Previous GeneCards Identifiers for IL10RB Gene
The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL10RB Gene
IL10RB (Interleukin 10 Receptor Subunit Beta) is a Protein Coding gene. Diseases associated with IL10RB include inflammatory bowel disease 25, early onset, autosomal recessive and autoinflammation, antibody deficiency, and immune dysregulation syndrome. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include receptor activity and interleukin-10 receptor activity. An important paralog of this gene is IFNAR1.
UniProtKB/Swiss-Prot for IL10RB Gene
Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.