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IL10RA Gene

protein-coding   GIFtS: 63
GCID: GC11P117857

Interleukin 10 Receptor, Alpha


(Previous symbol: IL10R)
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 10 Receptor, Alpha1 2     CD210a2
IL10R1 2 3 5     CDW210A2
Interleukin-10 Receptor Subunit 12 3     HIL-10R2
IL-10R12 3     Interleukin-10 Receptor Alpha Chain2
IL-10RA2 3     Interleukin-10 Receptor Subunit Alpha2
IL-10 Receptor Subunit Alpha2 3     CDw210a3
IL-10R Subunit 12 3     CD210 Antigen3
IL-10R Subunit Alpha2 3     IBD285
CD2102     

External Ids:    HGNC: 59641   Entrez Gene: 35872   Ensembl: ENSG000001103247   OMIM: 1469335   UniProtKB: Q136513   

Export aliases for IL10RA gene to outside databases

Previous GC identifers: GC11P120213 GC11P119368 GC11P117891 GC11P117394 GC11P117362 GC11P113790


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL10RA Gene:
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to
interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus
inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor
myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads
to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other
not protein-coding, have been found for this gene. (provided by RefSeq, Jan 2009)

GeneCards Summary for IL10RA Gene:
IL10RA (interleukin 10 receptor, alpha) is a protein-coding gene. Diseases associated with IL10RA include post-transplant lymphoproliferative disease, and inflammatory bowel disease 28, autosomal recessive. GO annotations related to this gene include interleukin-10 receptor activity and signal transducer activity.

UniProtKB/Swiss-Prot: I10R1_HUMAN, Q13651
Function: Receptor for IL10; binds IL10 with a high affinity

Gene Wiki entry for IL10RA (Interleukin 10 receptor, alpha subunit) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL10RA gene promoter:
         STAT1   Brachyury   STAT5A   NF-AT   E47   NF-AT2   STAT3   MRF-2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIL10RA promoter sequence
   Search Chromatin IP Primers for IL10RA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL10RA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23

IL10RA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL10RA gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P117857:  view genomic region     (about GC identifiers)

Start:
117,857,063 bp from pter      End:
117,872,198 bp from pter
Size:
15,136 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: I10R1_HUMAN, Q13651 (See protein sequence)
Recommended Name: Interleukin-10 receptor subunit alpha precursor  
Size: 578 amino acids; 63003 Da
5 PDB 3D structures from and Proteopedia for IL10RA:
1J7V (3D)        1LQS (3D)        1Y6K (3D)        1Y6M (3D)        1Y6N (3D)    
Secondary accessions: A8K6I0 B0YJ27

Explore the universe of human proteins at neXtProt for IL10RA: NX_Q13651

Explore proteomics data for IL10RA at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn50, Asn74, Asn110, Asn154, Asn177, Asn189
  • Modification sites at PhosphoSitePlus

  • See IL10RA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001549.2  
    ENSEMBL proteins: 
     ENSP00000227752   ENSP00000435317   ENSP00000436328   ENSP00000441397   ENSP00000443019  

    IL10RA Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for IL10RA
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    Browse Proteins at Cloud-Clone Corp.

    IL10RA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL10RA
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    Novus Biologicals IL10RA Antibodies
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    IL10RA Assay Products:

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    GenScript Custom Assay Services for IL10RA
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IL: Interleukins and interleukin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Interleukin 10 receptor, alpha subunit
    IL-10 receptor family

    2 InterPro protein domains:
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q13651

    ProtoNet protein and cluster: Q13651

    UniProtKB/Swiss-Prot: I10R1_HUMAN, Q13651
    Similarity: Belongs to the type II cytokine receptor family


    IL10RA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I10R1_HUMAN, Q13651
    Function: Receptor for IL10; binds IL10 with a high affinity

         Genatlas biochemistry entry for IL10RA:
    interleukin 10,receptor alpha,90-110kDa,expressed in hemopoietic cells and cell lines

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS8120391
    GO:0004872receptor activity TAS8407942
    GO:0004920interleukin-10 receptor activity IEA--
    GO:0005515protein binding IPI15837194
    GO:0019969interleukin-10 binding IEA--
         
    IL10RA for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for IL10RA:
     Decreased viability of wild-ty  Increased G1 DNA content  Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Il10ra):
     cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 

    IL10RA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Il10ratm1.2Jack for IL10RA

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL10RA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL10RA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL10RA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL10RA

    miRNA
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    Block miRNA regulation of human, mouse, rat IL10RA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL10RA (see all 11):
    hsa-miR-4303 hsa-miR-15a hsa-miR-497 hsa-miR-545 hsa-miR-3160-3p hsa-miR-424 hsa-miR-3919 hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmidIL10RA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL10RA
    Predesigned siRNA for gene silencing in human, mouse, rat IL10RA

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for IL10RA

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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL10RA (NM_001558)
    Sino Biological Human cDNA Clone for IL10RA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL10RA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL10RA

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    Browse ESI BIO Cell Lines and PureStem Progenitors for IL10RA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL10RA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    I10R1_HUMAN, Q13651: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS8407942
    GO:0016021integral component of membrane IEA--

    IL10RA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL10RA About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    PGC1Alpha Pathway0.51
    Glucocorticoid Receptor Signaling0.43
    STAT3 Pathway0.47
    Cytokine-cytokine receptor interaction0.43
    2TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51
    3Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    4PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    5ERK Signaling
    Molecular Mechanisms of Cancer0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL10RA (see all 14)
        THC Differentiation Pathway
    STAT3 Pathway
    IL-10 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    1 GeneGo (Thomson Reuters) Pathway for IL10RA
        Immune response IL-10 signaling pathway



    5 Kegg Pathways  (Kegg details for IL10RA):
        Cytokine-cytokine receptor interaction
    Jak-STAT signaling pathway
    Toxoplasmosis
    Tuberculosis
    Epstein-Barr virus infection


    IL10RA for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL10RA (see all 6): 
              Interferons & Receptors in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL10RA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IL10RA (Q136511, 2, 3 ENSP000002277524) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL10P223012, 3, ENSP000004122374MINT-24888 I2D: score=6 STRING: ENSP00000412237
    IL10RBQ083343, ENSP000002902004I2D: score=3 STRING: ENSP00000290200
    JAK1P234583, ENSP000003432044I2D: score=5 STRING: ENSP00000343204
    IFNAR2P485513I2D: score=1 
    CBLENSP000002640334STRING: ENSP00000264033
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8120391
    GO:0019221cytokine-mediated signaling pathway TAS8120391
    GO:0032496response to lipopolysaccharide IEA--

    IL10RA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL10RA (I10R1)

    3 Novoseek inferred chemical compound relationships for IL10RA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    il 10 60.4 6 17331973 (3), 16971956 (1), 18552348 (1)
    serine 0.605 1 12356680 (1)
    tyrosine 0 3 10433356 (2), 12802285 (1)



    IL10RA for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IL10RA gene: 
    NM_001558.3  

    Unigene Cluster for IL10RA:

    Interleukin 10 receptor, alpha
    Hs.504035  [show with all ESTs]
    Unigene Representative Sequence: AB209626
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000227752(uc010rxl.2 uc001prv.3 uc010rxm.2 uc010rxn.2)
    ENST00000530761 ENST00000533700 ENST00000526544 ENST00000534574 ENST00000531365
    ENST00000529924(uc001prw.3) ENST00000534335 ENST00000530178 ENST00000532009
    ENST00000525467 ENST00000541785 ENST00000545409

    miRNA
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    Block miRNA regulation of human, mouse, rat IL10RA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL10RA (see all 11):
    hsa-miR-4303 hsa-miR-15a hsa-miR-497 hsa-miR-545 hsa-miR-3160-3p hsa-miR-424 hsa-miR-3919 hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmidIL10RA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IL10RA
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    GenScript: all cDNA clones in your preferred vector: IL10RA (NM_001558)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat IL10RA
      QuantiFast Probe-based Assays in human, mouse, rat IL10RA

    Additional mRNA sequence: 

    AB209626.1 AK291645.1 AK301484.1 AK301492.1 AK313049.1 AK316146.1 AK316342.1 BC028082.1 
    JN591377.1 NR_026691.1 U00672.1 

    10 DOTS entries:

    DT.312248  DT.97790358  DT.92420103  DT.120706788  DT.86851042  DT.100693999  DT.100748917  DT.97836903 
    DT.95218156  DT.99929487 

    Selected AceView cDNA sequences (see all 75):

    BQ882188 BG758470 AA437226 NM_001558 AA297891 BX116559 BQ073097 AI375946 
    AI382483 BC028082 BQ063690 BX335076 N32329 BM924956 BI908667 U00672 
    AI089944 BI911968 C17295 AW514212 AA889391 CA309852 BX402044 BE139067 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IL10RA    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
    SP1:        -                                             
    SP2:                    -                                 
    SP3:        -           -                                 


    ECgene alternative splicing isoforms for IL10RA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IL10RA expression in normal human tissues (normalized intensities)      IL10RA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTTATTC
    IL10RA Expression
    About this image


    IL10RA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 7 entries
             Plasmacytoid Dendritic cells Peripheral Blood
             CD19+ B Cells   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Cord Blood Monocytes (CD14+)   
     
     Thymus (Hematopoietic System)
    IL10RA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL10RA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.504035

    UniProtKB/Swiss-Prot: I10R1_HUMAN, Q13651
    Tissue specificity: Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and
    kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and
    T-cells express high levels

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL10RA (see all 6): 
              Interferons & Receptors in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IL10RA
    OriGene qSTAR qPCR primer pairs in human, mouse for IL10RA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL10RA
    QuantiTect SYBR Green Assays in human, mouse, rat IL10RA
    QuantiFast Probe-based Assays in human, mouse, rat IL10RA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL10RA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL10RA gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il10ra1 , 5 interleukin 10 receptor, alpha1, 5 68.97(n)1
    57.89(a)1
      9 (24.84 cM)5
    161541  NM_008348.21  NP_032374.11 
     452538375 
    chicken
    (Gallus gallus)
    Aves IL10RA1 interleukin 10 receptor, alpha 49.59(n)
    36.42(a)
      419771  NM_001039597.1  NP_001034686.1 
    lizard
    (Anolis carolinensis)
    Reptilia IL10RA6
    interleukin 10 receptor, alpha
    30(a)
    1 ↔ 1
    GL343767.1(185802-187679)


    ENSEMBL Gene Tree for IL10RA (if available)
    TreeFam Gene Tree for IL10RA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IL10RA (see all 417)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0635434
    Inflammatory bowel disease 28 (IBD28)4--see VAR_0635432 G R mis40--------
    VAR_0635424
    Inflammatory bowel disease 28 (IBD28)4--see VAR_0635422 T I mis40--------
    rs1449395301,2
    --117718926(+) TGGTCC/TGAATA 2 -- us2k10--------
    rs455534381,2
    C,F--117718955(+) AGGGAA/TACCCA 2 -- us2k11Minor allele frequency- T:0.03NS 40
    rs42522411,2
    C,F,A--117719104(+) TGCAAA/GCACTT 2 -- us2k112Minor allele frequency- G:0.18NS NA WA CSA EA 494
    rs42522421,2
    C,F--117719282(+) TTTTTC/TGAAGA 2 -- us2k13Minor allele frequency- T:0.06NS WA 204
    rs1414506981,2
    --117719434(+) GGGAAC/TGCAGG 2 -- us2k10--------
    rs42522431,2
    C,F,A--117719536(+) ATTATC/TGTCTT 2 -- us2k1 tfbs313Minor allele frequency- T:0.17NS NA WA CSA EA 1438
    rs1508574561,2
    --117719556(+) AGGGGC/TTGGTG 2 -- us2k10--------
    rs42522991,2
    C--117719731(+) AGCGTG/TTGCTT 2 -- us2k15Minor allele frequency- T:0.24NS NA EA 218

    HapMap Linkage Disequilibrium report for IL10RA (117857063 - 117872198 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IL10RA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898407CNV Loss21882294

    Human Gene Mutation Database (HGMD): IL10RA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL10RA
    DNA2.0 Custom Variant and Variant Library Synthesis for IL10RA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 146933   
    OMIM disorders: 613148  
    UniProtKB/Swiss-Prot: I10R1_HUMAN, Q13651
  • Inflammatory bowel disease 28 (IBD28) [MIM:613148]: A chronic, relapsing inflammation of the
    gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis
    phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most
    frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may
    contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the
    inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not
    observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • Selected diseases for IL10RA (see all 74):    About MalaCards
    post-transplant lymphoproliferative disease    inflammatory bowel disease 28, autosomal recessive    giant cell myocarditis    cytomegalovirus retinitis
    inflammatory bowel disease 28, early onset, autosomal recessive    extrapulmonary tuberculosis    neuroretinitis    inflammatory bowel disease 25, early onset, autosomal recessive
    visceral leishmaniasis    myocarditis    idiopathic pulmonary fibrosis    cblc
    rubella    inflammatory bowel disease    patent ductus arteriosus    toxoplasmosis
    burkitt's lymphoma    dengue hemorrhagic fever    chagas disease    hepatitis b virus infection


    IL10RA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for IL10RA gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 27.7 2 16200606 (1), 17845543 (1)
    rheumatoid arthritis 24.7 5 12673894 (3), 16200606 (1), 19772791 (1)
    necrosis 23.7 6 18552348 (1), 16859503 (1), 17241871 (1), 18308712 (1) (see all 5)
    psoriasis 22.3 1 9550434 (1)
    burkitt lymphoma 19.6 1 8120391 (1)
    dermatitis atopic 17.2 3 10563471 (2)
    lupus erythematosus systemic 13.7 4 17062437 (2), 19772791 (1), 10556270 (1)
    tumors 3.09 5 18344594 (3), 18552348 (1), 17241871 (1)
    melanoma 1.4 3 9178819 (2), 14726694 (1)
    carcinoma squamous cell 0 1 11351253 (1)

    Genetic Association Database (GAD): IL10RA
    Human Genome Epidemiology (HuGE) Navigator: IL10RA (59 documents)

    Export disorders for IL10RA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL10RA gene, integrated from 10 sources (see all 192):
    (articles sorted by number of sources associating them with IL10RA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression cloning and characterization of a human IL-10 receptor. (PubMed id 8120391)1, 2, 3, 9 Liu Y.... Moore K.W. (J. Immunol. 1994)
    2. Influence of IL-10RA and IL-22 polymorphisms on outcome of hepatitis C virus infection. (PubMed id 17845543)1, 4, 9 Hennig B.J....Hill A.V. (Liver Int. 2007)
    3. Interleukin 10 receptor alpha subunit (IL-10RA) gene polymorphism and IL-10 serum levels in Egyptian atopic patients. (PubMed id 20232770)1, 4, 9 Hussein P.Y....Bakr N. (amp 2010)
    4. IL10R1 loss-of-function alleles in rheumatoid arthritis and systemic lupus erythematosus. (PubMed id 19772791)1, 4, 9 Hermann J....Gasche C. (Clin. Exp. Rheumatol. 2009)
    5. Polymorphisms of interleukin-10 and its receptor and lung function in COPD. (PubMed id 17331973)1, 4, 9 He J.Q....Sandford A.J. (Eur. Respir. J. 2007)
    6. Gene polymorphisms in Toll-like receptors, interleukin-10, and interleukin-10 receptor alpha and lymphoma risk. (PubMed id 16971956)1, 4, 9 Nieters A....Becker N. (Genes Immun. 2006)
    7. Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. (PubMed id 11485736)1, 2, 9 Josephson K.... Walter M.R. (Immunity 2001)
    8. The IL-10R1 S138G loss-of-function allele and ulcerative colitis. (PubMed id 18800073)1, 4, 9 Grundtner P....Gasche C. (Genes Immun. 2009)
    9. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. (PubMed id 19890111)1, 2, 9 Glocker E.O....Klein C. (N. Engl. J. Med. 2009)
    10. Tourette's syndrome is not associated with interleukin-10 receptor 1 variants on chromosome 11q23.3. (PubMed id 17961716)1, 4, 9 Kindler J....Gasche C. (Psychiatry Res 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3587 HGNC: 5964 AceView: IL10RA Ensembl:ENSG00000110324 euGenes: HUgn3587
    ECgene: IL10RA Kegg: 3587 H-InvDB: IL10RA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IL10RA Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/il10ra/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL10RA gene:
    Search GeneIP for patents involving IL10RA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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