IL10RA Gene
protein-coding GIFtS: 61
GCID: GC11P117891
|
|
interleukin 10 receptor, alpha
(Previous symbol: IL10R)
| |
Aliases
for IL10RA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Interleukin 10 Receptor, Alpha1 2 | | IL-10 Receptor Subunit Alpha2 3 | | IL10R1 2 3 5 | | IL-10R Subunit 12 3 | | CD2101 2 | | IL-10R Subunit Alpha2 3 | | CD210a1 2 | | Interleukin-10 Receptor Alpha Chain2 | | CDW210A1 2 | | Interleukin-10 Receptor Subunit Alpha2 | | HIL-10R1 2 | | CDw210a3 | | Interleukin-10 Receptor Subunit 12 3 | | CD210 Antigen3 | | IL-10R12 3 | | IBD285 | | IL-10RA2 3 | | |
| External Ids: | HGNC: 59641 | Entrez Gene: 35872 | Ensembl: ENSG000001103247 | OMIM: 1469335 | UniProtKB: Q136513 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n407223 | |
Export aliases for IL10RA gene to outside databasesPrevious GC identifers: GC11P120213 GC11P119368 GC11P117394 GC11P117362 GC11P113790
Summaries
for IL10RA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IL10RA:
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferonreceptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits thesynthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cellsthrough the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosinephosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other notprotein-coding, have been found for this gene. (provided by RefSeq, Jan 2009)
UniProtKB/Swiss-Prot: I10R1_HUMAN, Q13651Function: Receptor for IL10; binds IL10 with a high affinity
Gene Wiki entry for IL10RA (Interleukin 10 receptor, alpha subunit)
|
Genomic Views
for IL10RA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IL10RA gene promoter:
STAT1 Brachyury STAT5A NF-AT E47 NF-AT2 STAT3 MRF-2 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for IL10RA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL10RA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23IL10RA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P117891: view genomic region
(about GC identifiers)
Start:
|
117,857,063 bp from pter |
End:
|
117,872,198 bp from pter |
Size:
|
15,136 bases |
Orientation:
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plus strand |
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Proteins
for IL10RA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: I10R1_HUMAN, Q13651 (See
protein sequence)Recommended Name: Interleukin-10 receptor subunit alpha precursor Size: 578 amino acids; 63003 Da
Subcellular location: Membrane; Single-pass type I membrane protein
5 PDB 3D structures from  and Proteopedia  for IL10RA:1J7V (3D)
1LQS (3D)
1Y6K (3D)
1Y6M (3D)
1Y6N (3D)
Secondary accessions: A8K6I0 B0YJ27Explore the universe of human proteins at neXtProt for IL10RA: NX_Q13651
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13651
IL10RA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001549.2
ENSEMBL proteins: ENSP00000227752 ENSP00000435317 ENSP00000436328 ENSP00000441397 ENSP00000443019
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
IL10RA for ontologies About GeneDecksing
IL10RA Antibody Products:
Assay Products for IL10RA: |
Protein
Domains /
Families
for IL10RA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IL10RA for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13651ProtoNet protein and cluster: Q13651 UniProtKB/Swiss-Prot: I10R1_HUMAN, Q13651Similarity: Belongs to the type II cytokine receptor family |
Function
for IL10RA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: I10R1_HUMAN, Q13651Function: Receptor for IL10; binds IL10 with a high affinity Genatlas biochemistry entry for IL10RA:interleukin 10,receptor alpha,90-110kDa,expressed in hemopoietic cells and cell lines
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL10RA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL10RA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IL10RA (NM_001558) | |  | Sino Biological Human cDNA Clone for IL10RA | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL10RA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL10RA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL10RA |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
IL10RA for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for IL10RA:
Animal Models:
Mouse knock-out Il10ratm1.2Jack for IL10RA
5 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Il10ra):
IL10RA for phenotypes About GeneDecksing
|
Pathways & Interactions
for IL10RA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TGF-Beta Pathway | | | 2 | PEDF Induced Signaling | | | 3 | Akt Signaling | | | 4 | Development_PDGF signaling via STATs and NF-kB | | | 5 | IL-10 Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for IL10RA
5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL10RA (see all 14)
1  GeneGo (Thomson Reuters) Pathway for IL10RA
4 
Kegg Pathways (Kegg details for IL10RA):
IL10RA for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL10RA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 19)
5/22 Interacting proteins for IL10RA (Q136511, 2, 3 ENSP000002277524) via UniProtKB, MINT, STRING, and/or I2D (see all 22)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
IL10RA for ontologies About GeneDecksing
|
Drugs & Compounds
for IL10RA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
IL10RA for compounds About GeneDecksing
 Browse Tocris compounds for IL10RA
3 Novoseek chemical compound relationships for IL10RA gene About this table
Search CenterWatch for drugs/clinical trials and news about IL10RA / I10R1
|
Transcripts
for IL10RA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IL10RA gene: NM_001558.3 Unigene Cluster for IL10RA: Interleukin 10 receptor, alpha Hs.504035 [show with all ESTs]Unigene Representative Sequence: AB20962613 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000227752(uc010rxl.2 uc001prv.3 uc010rxm.2 uc010rxn.2)
ENST00000530761 ENST00000533700 ENST00000526544 ENST00000534574 ENST00000531365
ENST00000529924(uc001prw.3) ENST00000534335 ENST00000530178 ENST00000532009
ENST00000525467 ENST00000541785 ENST00000545409
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL10RA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL10RA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IL10RA (NM_001558) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IL10RA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL10RA |
Additional cDNA sequence: AB209626.1 AK291645.1 AK301484.1 AK301492.1 AK313049.1 AK316146.1 AK316342.1 BC028082.1 JN591377.1 NR_026691.1 U00672.1 10 DOTS entries: DT.312248 DT.97790358 DT.92420103 DT.120706788 DT.86851042 DT.100693999 DT.100748917 DT.97836903 DT.95218156 DT.99929487 24/75 AceView cDNA sequences (see all 75): AA297891 BQ063690 AA437226 NM_001558 BQ073097 BQ882188 BX116559 AI375946 BC028082 BG758470 AI382483 BI910550 BI911968 CD742904 CD703757 BX335075 AA889391 BM924956 BX402044 AA442290 AW575501 U00672 BQ015567 N32329
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for IL10RA About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | - | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for IL10RA
|
Expression
for IL10RA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IL10RA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTTTATTC
About this image
See IL10RA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL10RA
SOURCE GeneReport for Unigene cluster: Hs.504035
UniProtKB/Swiss-Prot: I10R1_HUMAN, Q13651Tissue specificity: Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney.Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cellsexpress high levels
SABiosciences Expression via Pathway-Focused PCR Arrays including IL10RA (see all 6):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL10RA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL10RA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL10RA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL10RA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL10RA |
Orthologs
for IL10RA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IL10RA gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for IL10RA (if available)
TreeFam Gene Tree for IL10RA (if available) |
Paralogs
for IL10RA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IL10RA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IL10RA (117857063 - 117872198 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IL10RA: --
Human Gene Mutation Database (HGMD): IL10RA
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL10RA |
|
Disorders
/ Diseases
for IL10RA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IL10RA for disorders About GeneDecksing
OMIM gene information: 146933
OMIM disorders: 613148
UniProtKB/Swiss-Prot: I10R1_HUMAN, Q13651
Defects in IL10RA are the cause of inflammatory bowel disease type 28 (IBD28) [MIM:613148]. It is a chronic,relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease andulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to theanus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural anddiscontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, inulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas andgranulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints
20/74  diseases for IL10RA (see all 74): About MalaCardsinflammatory bowel disease 28, early onset, autosomal recessive post-transplant lymphoproliferative disease diffuse large b-cell lymphoma patent ductus arteriosus
graft versus host disease inflammatory bowel disease b-cell lymphomas dengue hemorrhagic fever
non-hodgkin lymphoma hemorrhagic fever giant cell myocarditis visceral leishmaniasis
lupus erythematosus burkitt's lymphoma idiopathic pulmonary fibrosis systemic lupus erythematosus
hodgkin's lymphoma pulmonary fibrosis acute lymphoblastic leukemia rheumatoid arthritis
10/14 Novoseek disease relationships for IL10RA gene (see all 14) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| inflammation |
27.7 |
2 |
16200606 (1), 17845543 (1) |
| rheumatoid arthritis |
24.7 |
5 |
12673894 (3), 16200606 (1), 19772791 (1) |
| necrosis |
23.7 |
6 |
18552348 (1), 16859503 (1), 17241871 (1), 18308712 (1) (see all 5) |
| psoriasis |
22.3 |
1 |
9550434 (1) |
| burkitt lymphoma |
19.6 |
1 |
8120391 (1) |
| dermatitis atopic |
17.2 |
3 |
10563471 (2) |
| lupus erythematosus systemic |
13.7 |
4 |
17062437 (2), 19772791 (1), 10556270 (1) |
| tumors |
3.09 |
5 |
18344594 (3), 18552348 (1), 17241871 (1) |
| melanoma |
1.4 |
3 |
9178819 (2), 14726694 (1) |
| carcinoma squamous cell |
0 |
1 |
11351253 (1) |
Genetic Association Database (GAD): IL10RA
Human Genome Epidemiology (HuGE) Navigator: IL10RA (59 documents)
Export disorders for IL10RA gene to outside databases
|
Publications
for IL10RA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IL10RA gene, integrated from 9 sources (see all 184):
(articles sorted by number of sources associating them with IL10RA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Expression cloning and characterization of a human IL-10 receptor. (PubMed id 8120391)1, 2, 3, 9 Liu Y.... Moore K.W. (1994)
- Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. (PubMed id 11485736)1, 2, 9 Josephson K.... Walter M.R. (2001)
- Inflammatory bowel disease and mutations affecting th e interleukin-10 receptor. (PubMed id 19890111)1, 2, 9 Glocker E.O....Klein C. (2009)
- Same structure, different function crystal structure of the Epstein- Barr virus IL-10 bound to the soluble IL-10R1 chain. (PubMed id 15837194)1, 2, 9 Yoon S.I.... Walter M.R. (2005)
- Bi-allelic presence of the interleukin-10 receptor 1 G330R allele is associated with cirrhosis in chronic HCV-1 infection. (PubMed id 15729365)1, 4, 9 Hofer H....Gasche C. (2005)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)1, 4 Saito T....Kawata S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1. (PubMed id 12093920)1, 2 Jones B.C....Walter M.R. (2002)
- Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through IL-6 response elements. (PubMed id 8662928)1, 9 Lai C.F....Baumann H. (1996)
|
External Searches for IL10RA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IL10RA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IL10RA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IL10RA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IL10RA | Pharmacogenomics, SNPs, Pathways | | SeattleSNPs | http://pga.gs.washington.edu/data/il10ra/ |
|
| | |
About This Section
| Patent Information for IL10RA gene:
Search GeneIP for patents involving IL10RA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IL10RA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IL10RA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL10RA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL10RA | | | OriGene Protein Over-expression Lysate for IL10RA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IL10RA | | OriGene 3'-UTR Clone for IL10RA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL10RA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL10RA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for IL10RA | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IL10RA | | OriGene Custom Protein Services for IL10RA | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IL10RA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL10RA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL10RA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL10RA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL10RA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL10RA |
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| | | | Search Tocris compounds for IL10RA |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL10RA |
|  |  |  | | | | Search ThermoFisher Antibodies for IL10RA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL10RA |
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GeneCards Homepage -
Last full update: 18 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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