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Aliases for IL10RA Gene

Aliases for IL10RA Gene

  • Interleukin 10 Receptor, Alpha 2 3
  • IL10R 3 4 6
  • Interleukin-10 Receptor Subunit 1 3 4
  • IL-10 Receptor Subunit Alpha 3 4
  • IL-10R Subunit Alpha 3 4
  • IL-10R Subunit 1 3 4
  • CDW210A 3 4
  • IL-10R1 3 4
  • IL-10RA 3 4
  • Interleukin-10 Receptor Subunit Alpha 3
  • Interleukin-10 Receptor Alpha Chain 3
  • CD210 Antigen 4
  • HIL-10R 3
  • CD210a 3
  • CD210 3
  • IBD28 6

External Ids for IL10RA Gene

Previous Symbols for IL10RA Gene

  • IL10R

Summaries for IL10RA Gene

Entrez Gene Summary for IL10RA Gene

  • The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]

GeneCards Summary for IL10RA Gene

IL10RA (Interleukin 10 Receptor, Alpha) is a Protein Coding gene. Diseases associated with IL10RA include giant cell myocarditis and post-transplant lymphoproliferative disease. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include signal transducer activity and interleukin-10 receptor activity.

UniProtKB/Swiss-Prot for IL10RA Gene

  • Receptor for IL10; binds IL10 with a high affinity

Gene Wiki entry for IL10RA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL10RA Gene

Genomics for IL10RA Gene

Genomic Location for IL10RA Gene

Start:
117,986,348 bp from pter
End:
118,001,483 bp from pter
Size:
15,136 bases
Orientation:
Plus strand

Genomic View for IL10RA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL10RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL10RA Gene

Regulatory Elements for IL10RA Gene

Proteins for IL10RA Gene

  • Protein details for IL10RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13651-I10R1_HUMAN
    Recommended name:
    Interleukin-10 receptor subunit alpha
    Protein Accession:
    Q13651
    Secondary Accessions:
    • A8K6I0
    • B0YJ27

    Protein attributes for IL10RA Gene

    Size:
    578 amino acids
    Molecular mass:
    63003 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL10RA Gene

neXtProt entry for IL10RA Gene

Proteomics data for IL10RA Gene at MOPED

Post-translational modifications for IL10RA Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn50, Asn74, Asn110, Asn154, Asn177, and Asn189

Other Protein References for IL10RA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL10RA Gene

Domains for IL10RA Gene

Gene Families for IL10RA Gene

HGNC:
  • CD :CD molecules
  • IL :Interleukins and interleukin receptors
IUPHAR :

Protein Domains for IL10RA Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

I10R1_HUMAN
Family:
  • Belongs to the type II cytokine receptor family.:
    • Q13651
genes like me logo Genes that share domains with IL10RA: view

Function for IL10RA Gene

Molecular function for IL10RA Gene

GENATLAS Biochemistry: interleukin 10,receptor alpha,90-110kDa,expressed in hemopoietic cells and cell lines
UniProtKB/Swiss-Prot Function: Receptor for IL10; binds IL10 with a high affinity

Gene Ontology (GO) - Molecular Function for IL10RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 8120391
GO:0004872 receptor activity TAS 8407942
GO:0004920 interleukin-10 receptor activity IBA --
GO:0005515 protein binding IPI 15837194
GO:0019969 interleukin-10 binding IEA --
genes like me logo Genes that share ontologies with IL10RA: view
genes like me logo Genes that share phenotypes with IL10RA: view

Animal Models for IL10RA Gene

MGI Knock Outs for IL10RA:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IL10RA Gene

Localization for IL10RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL10RA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL10RA Gene COMPARTMENTS Subcellular localization image for IL10RA gene
Compartment Confidence
plasma membrane 4
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for IL10RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with IL10RA: view

Pathways for IL10RA Gene

genes like me logo Genes that share pathways with IL10RA: view

Pathways by source for IL10RA Gene

Gene Ontology (GO) - Biological Process for IL10RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0032496 response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with IL10RA: view

Compounds for IL10RA Gene

(3) Novoseek inferred chemical compound relationships for IL10RA Gene

Compound -log(P) Hits PubMed IDs
il 10 60.4 5
serine 0.605 1
tyrosine 0 3
genes like me logo Genes that share compounds with IL10RA: view

Transcripts for IL10RA Gene

Unigene Clusters for IL10RA Gene

Interleukin 10 receptor, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL10RA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: -
SP2: -
SP3: - -

Relevant External Links for IL10RA Gene

GeneLoc Exon Structure for
IL10RA
ECgene alternative splicing isoforms for
IL10RA

Expression for IL10RA Gene

mRNA expression in normal human tissues for IL10RA Gene

mRNA differential expression in normal tissues according to GTEx for IL10RA Gene

This gene is overexpressed in Whole Blood (13.0) and Spleen (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL10RA Gene

SOURCE GeneReport for Unigene cluster for IL10RA Gene Hs.504035

mRNA Expression by UniProt/SwissProt for IL10RA Gene

Q13651-I10R1_HUMAN
Tissue specificity: Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels
genes like me logo Genes that share expressions with IL10RA: view

Orthologs for IL10RA Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL10RA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL10RA 36
  • 98.96 (n)
  • 98.62 (a)
IL10RA 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL10RA 36
  • 78.68 (n)
  • 69.5 (a)
IL10RA 37
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL10RA 36
  • 79.64 (n)
  • 72.14 (a)
IL10RA 37
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il10ra 36
  • 68.97 (n)
  • 57.89 (a)
Il10ra 16
Il10ra 37
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL10RA 37
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL10RA 37
  • 35 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il10ra 36
  • 68.49 (n)
  • 57.77 (a)
chicken
(Gallus gallus)
Aves IL10R1 37
  • 29 (a)
OneToOne
IL10RA 36
  • 49.59 (n)
  • 36.42 (a)
lizard
(Anolis carolinensis)
Reptilia IL10RA 37
  • 30 (a)
OneToOne
Species with no ortholog for IL10RA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL10RA Gene

ENSEMBL:
Gene Tree for IL10RA (if available)
TreeFam:
Gene Tree for IL10RA (if available)

Paralogs for IL10RA Gene

No data available for Paralogs for IL10RA Gene

Variants for IL10RA Gene

Sequence variations from dbSNP and Humsavar for IL10RA Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs9610 -- 118,001,371(+) AATTC(A/G)TAGGG utr-variant-3-prime, nc-transcript-variant
rs11263 -- 118,001,178(-) AAATA(A/G)AGCTT utr-variant-3-prime, nc-transcript-variant
rs752174 -- 117,999,774(+) GGCCC(C/T)AGCCA utr-variant-3-prime, nc-transcript-variant
rs2228054 -- 117,993,398(+) GTGCC(A/G)GGAAA synonymous-codon, reference, nc-transcript-variant
rs2228055 - 117,994,131(+) AGTGC(A/G)TCTCC reference, missense, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for IL10RA Gene

Variant ID Type Subtype PubMed ID
nsv898407 CNV Loss 21882294

Relevant External Links for IL10RA Gene

HapMap Linkage Disequilibrium report
IL10RA
Human Gene Mutation Database (HGMD)
IL10RA

Disorders for IL10RA Gene

(1) OMIM Diseases for IL10RA Gene (146933)

UniProtKB/Swiss-Prot

I10R1_HUMAN
  • Inflammatory bowel disease 28 (IBD28) [MIM:613148]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269 PubMed:19890111, ECO:0000269 PubMed:23839161, ECO:0000269 PubMed:24785691}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(14) Novoseek inferred disease relationships for IL10RA Gene

Disease -log(P) Hits PubMed IDs
inflammation 27.7 2
rheumatoid arthritis 24.7 5
necrosis 23.7 5
psoriasis 22.3 1
burkitt lymphoma 19.6 1

Relevant External Links for IL10RA

Genetic Association Database (GAD)
IL10RA
Human Genome Epidemiology (HuGE) Navigator
IL10RA
genes like me logo Genes that share disorders with IL10RA: view

Publications for IL10RA Gene

  1. Expression cloning and characterization of a human IL-10 receptor. (PMID: 8120391) Liu Y. … Moore K.W. (J. Immunol. 1994) 2 3 4 23
  2. Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. (PMID: 11485736) Josephson K. … Walter M.R. (Immunity 2001) 3 4 23
  3. Bi-allelic presence of the interleukin-10 receptor 1 G330R allele is associated with cirrhosis in chronic HCV-1 infection. (PMID: 15729365) Hofer H. … Gasche C. (Genes Immun. 2005) 3 23 49
  4. Same structure, different function crystal structure of the Epstein- Barr virus IL-10 bound to the soluble IL-10R1 chain. (PMID: 15837194) Yoon S.I. … Walter M.R. (Structure 2005) 3 4 23
  5. Gene polymorphisms in Toll-like receptors, interleukin-10, and interleukin-10 receptor alpha and lymphoma risk. (PMID: 16971956) Nieters A. … Becker N. (Genes Immun. 2006) 3 23 49

Products for IL10RA Gene

Sources for IL10RA Gene

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