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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IL10 Gene

protein-coding   GIFtS: 66
GCID: GC01M206940

Interleukin 10

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interleukin 101 2     GVHDS2
Cytokine Synthesis Inhibitory Factor1 2 3     IL10A2
CSIF2 3 5     TGIF2
T-Cell Growth Inhibitory Factor1 2     interleukin-102
IL-102 3     

External Ids:    HGNC: 59621   Entrez Gene: 35862   Ensembl: ENSG000001366347   OMIM: 1240925   UniProtKB: P223013   

Export aliases for IL10 gene to outside databases

Previous GC identifers: GC01M205600 GC01M202651 GC01M203584 GC01M204024 GC01M203329 GC01M205007 GC01M177639


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL10 Gene:
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by
lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the
expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B
cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is
involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of
this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with
an increased susceptibility to HIV-1 infection and rheumatoid arthritis.(provided by RefSeq, May 2011)

GeneCards Summary for IL10 Gene: 
IL10 (interleukin 10) is a protein-coding gene. Diseases associated with IL10 include adult pulmonary langerhans cell histiocytosis, and buruli ulcer disease, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Allograft rejection. GO annotations related to this gene include growth factor activity and interleukin-10 receptor binding.

UniProtKB/Swiss-Prot: IL10_HUMAN, P22301
Function: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF
produced by activated macrophages and by helper T-cells

Gene Wiki entry for IL10 (Interleukin 10) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IL10 gene promoter:
         GR   Pbx1a   Sp1   GR-beta   CREB   deltaCREB   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL10 promoter sequence
   Search SABiosciences Chromatin IP Primers for IL10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31-q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q31-q32

IL10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL10 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M206940:  view genomic region     (about GC identifiers)

Start:
206,940,947 bp from pter      End:
206,945,839 bp from pter
Size:
4,893 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IL10_HUMAN, P22301 (See protein sequence)
Recommended Name: Interleukin-10 precursor  
Size: 178 amino acids; 20517 Da
Subunit: Homodimer
Subcellular location: Secreted
6/7 PDB 3D structures from and Proteopedia for IL10 (see all 7):
1ILK (3D)        1INR (3D)        1J7V (3D)        1LK3 (3D)        1Y6K (3D)        2H24 (3D)    

Explore the universe of human proteins at neXtProt for IL10: NX_P22301

Explore proteomics data for IL10 at MOPED 

IL10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

IL10 Protein Expression

REFSEQ proteins: NP_000563.1  
ENSEMBL proteins: 
 ENSP00000412237  

Human Recombinant Protein Products for IL10: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for IL10 (IL-10)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for IL10
OriGene Custom MassSpec 
OriGene Custom Protein Services for IL10
GenScript Purified and Recombinant Proteins for IL10
Novus Biologicals IL10 Proteins
Novus Biologicals IL10 Lysates
Sino Biological Recombinant Protein for IL10
Sino Biological Cell Lysate for IL10 
ProSpec Recombinant Protein for IL10
Cloud-Clone Corp. Proteins for IL10 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IDA10443688

IL10 for ontologies           About GeneDecksing



IL10 Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of IL10
R&D Systems Antibodies for IL10 (IL-10)
Cell Signaling Technology (CST) Antibodies for IL10 
OriGene Antibodies for IL10
OriGene Custom Antibody Services for IL10
GenScript Custom Superior Antibodies Services for IL10
Novus Biologicals IL10 Antibodies
Abcam antibodies for IL10
Cloud-Clone Corp. Antibodies for IL10 
ThermoFisher Antibody for IL10
LSBio Antibodies in human, mouse, rat for IL10 

Assay Products for IL10: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for IL10
R&D Systems Flow Cytometry Kits for IL10 (IL-10)         (see all)
GenScript Custom Assay Services for IL10
Enzo Life Sciences assays for IL10
Cloud-Clone Corp. ELISAs for IL10 
Cloud-Clone Corp. CLIAs for IL10


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IL: Interleukins and interleukin receptors

5 InterPro protein domains:
 IPR012351 4_helix_cytokine_core
 IPR020423 Interleukin-10_CS
 IPR009079 4_helix_cytokine-like_core
 IPR020443 Interleukin-10/19/20/24
 IPR000098 Interleukin_10

Graphical View of Domain Structure for InterPro Entry P22301

ProtoNet protein and cluster: P22301

1 Blocks protein domain: IPB000098 Interleukin-10

UniProtKB/Swiss-Prot: IL10_HUMAN, P22301
Similarity: Belongs to the IL-10 family


IL10 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: IL10_HUMAN, P22301
Function: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF
produced by activated macrophages and by helper T-cells

     Genatlas biochemistry entry for IL10:
interleukin 10,20.5kDa,cytokine synthesis inhibitory factor,costimulator of proliferation and differentiation of
B,T,mast cell

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity NAS10443688
GO:0005141interleukin-10 receptor binding NAS1847510
GO:0008083growth factor activity NAS1371884
     
IL10 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for IL10:
 Decreased viability with pacli 

     15/24 MGI mutant phenotypes (inferred from 11 alleles(MGI details for Il10) (see all 24):
 behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
 embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
 immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 

IL10 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for IL10: Il10tm1.1Roer Il10tm1Cgn

   inGenious Targeting Laboratory - Custom generated mouse model solutions for IL10 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IL10

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL10 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL10 

10/306 SABiosciences Target genes for IL10 (see all 306):
ABAT ACPT ACTG1 ACTL8 ADAM30 AIPL1 ALPP ANGPTL5 ANKRD20A1 ANKRD20A2

miRNA
Products:
    
miRTarBase miRNAs that target IL10:
hsa-mir-106a (MIRT005082)

QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL10
8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate IL10 (see all 37):
hsa-miR-361-5p hsa-let-7d hsa-miR-513a-5p hsa-miR-374a hsa-miR-29b-1* hsa-miR-3916 hsa-let-7g hsa-let-7a
SwitchGear 3'UTR luciferase reporter plasmidIL10 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL10
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL10

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for IL10
Sirion Biotech Customized adenovirus for overexpression of IL10

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for IL10 (see all 6)
OriGene ORF clones in mouse, rat for IL10
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL10 (NM_000572)
Sino Biological Human cDNA Clone for IL10
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL10
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL10
Sirion Biotech Customized lentivirus for stable overexpression of IL10 
                     Customized lentivirus expression plasmids for stable overexpression of IL10 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for IL10
Search LifeMap BioReagents cell lines for IL10
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL10


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for IL10 About   (see all 30)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation0.94
NFAT Signaling and Lymphocyte Interactions0.57
MIF Regulation of Innate Immune Cells0.94
PGC1Alpha Pathway0.51
PEDF Induced Signaling0.73
STAT3 Pathway0.47
all-trans-Retinoic Acid Signaling in Brain0.71
Endothelin-1 Signaling Pathway0.46
2Allograft rejection
Allograft rejection0.69
Intestinal immune network for IgA production0.42
Autoimmune thyroid disease0.62
THC Differentiation Pathway0.37
Asthma0.47
3TGF-Beta Pathway
TGF-Beta Pathway0.60
Regulation of eIF4 and p70S6K0.43
MAPK Family Pathway0.60
SOCS Pathway0.40
JAK-STAT Pathway0.57
4Akt Signaling
Akt Signaling0.60
Tec Kinases Signaling0.55
p38 Signaling0.60
5Rho Family GTPases
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 EMD Millipore Pathways for IL10
    Immune response IL-10 signaling pathway
Apoptosis and survival APRIL and BAFF signaling

2 R&D Systems Pathways for IL10
    Th1 Differentiation
IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL10 (see all 28)
    THC Differentiation Pathway
Endothelin-1 Signaling Pathway
IL-10 Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C

1 Cell Signaling Technology (CST) Pathway for IL10
    Lymphocyte Signaling

2 GeneGo (Thomson Reuters) Pathways for IL10
    Apoptosis and survival APRIL and BAFF signaling
Immune response IL-10 signaling pathway

4 BioSystems Pathways for IL10
    Cytokines and Inflammatory Response
SIDS Susceptibility Pathways
IL4-mediated signaling events
Regulation of nuclear SMAD2/3 signaling



5/19         Kegg Pathways  (Kegg details for IL10) (see all 19):
    Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
T cell receptor signaling pathway
Intestinal immune network for IgA production
Pertussis


IL10 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IL10

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/18 Interacting proteins for IL10 (P223012, 3 ENSP000004122374) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
InteractantInteraction Details
GeneCardExternal ID(s)
IL10RAQ136512, 3, ENSP000002277524MINT-24888 I2D: score=6 STRING: ENSP00000227752
IL10RBQ083343, ENSP000002902004I2D: score=2 STRING: ENSP00000290200
A2MP010233, ENSP000003239294I2D: score=2 STRING: ENSP00000323929
TLR4O002063, ENSP000003630894I2D: score=1 STRING: ENSP00000363089
IFNAR2P485513I2D: score=1 
About this table

Gene Ontology (GO): 5/50 biological process terms (GO ID links to tree view) (see all 50):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001818negative regulation of cytokine production ----
GO:0002237response to molecule of bacterial origin IDA17449476
GO:0002740negative regulation of cytokine secretion involved in immune response IDA10443688
GO:0002875negative regulation of chronic inflammatory response to antigenic stimulus IEA--
GO:0002904positive regulation of B cell apoptotic process IDA9184696

IL10 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL10 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL10

10/132 Novoseek inferred chemical compound relationships for IL10 gene (see all 132)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
il 10 94.6 1439 16331571 (7), 19771178 (7), 12394188 (7), 16954457 (7) (see all 99)
rantes 79.9 287 10048682 (5), 16911685 (5), 17460443 (5), 17015691 (4) (see all 99)
il-12 72.4 47 11479428 (3), 11403227 (3), 17324967 (2), 18508030 (2) (see all 36)
endotoxin 67.9 214 7561121 (8), 15637455 (6), 11176172 (5), 12566670 (4) (see all 99)
pge2 63.7 390 9002960 (6), 15219461 (6), 8018602 (6), 12496396 (5) (see all 99)
ammonium trichloro(dioxoethylene-o,o')tellurate 63.1 3 20100863 (1), 14996748 (1)
ionomycin 61.6 54 16265694 (2), 9518518 (2), 18023089 (2), 10674971 (1) (see all 48)
allergens 58.3 40 16238790 (2), 11564436 (2), 12731045 (2), 9590218 (1) (see all 30)
neopterin 58.1 80 8844339 (4), 15284959 (3), 9339750 (3), 11051235 (3) (see all 46)
ccl3 57.7 24 20041183 (2), 16501053 (1), 18239321 (1), 14578205 (1) (see all 18)

Search CenterWatch for drugs/clinical trials and news about IL10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL10 gene: 
NM_000572.2  

Unigene Cluster for IL10:

Interleukin 10
Hs.193717  [show with all ESTs]
Unigene Representative Sequence: BC022315
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000423557(uc001hen.1) ENST00000471071 ENST00000367099
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL10
8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate IL10 (see all 37):
hsa-miR-361-5p hsa-let-7d hsa-miR-513a-5p hsa-miR-374a hsa-miR-29b-1* hsa-miR-3916 hsa-let-7g hsa-let-7a
SwitchGear 3'UTR luciferase reporter plasmidIL10 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for IL10
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL10
Clone
Products:
     
OriGene clones in human, mouse for IL10 (see all 6)
OriGene ORF clones in mouse, rat for IL10
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: IL10 (NM_000572)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL10
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL10
Sirion Biotech Customized lentivirus for stable overexpression of IL10 
                     Customized lentivirus expression plasmids for stable overexpression of IL10 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for IL10
OriGene qSTAR qPCR primer pairs in human, mouse for IL10
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL10
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL10
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL10

Additional mRNA sequence: 

AF043333.1 AY029171.1 BC022315.1 BC104252.1 BC104253.1 CR541993.1 CR542028.1 EU751618.2 
EU751619.2 M57627.1 

2 DOTS entries:

DT.207856  DT.40106255 

14 AceView cDNA sequences:

AF043333 NM_000572 M57627 AY029171 CD369014 CA308268 CR541993 BC022315 
CR542028 CD641785 AA382010 T29794 AW951607 BG538741 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL10 expression in normal human tissues (normalized intensities)      IL10 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
IL10 Expression
About this image


IL10 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/4 selected tissues (see all 4) fully expand
 
 Blood (Hematopoietic System)    fully expand to see all 3 entries
         Bone marrow-derived hematopoietic stem cells
         cd31+ cells   
 
 Endothelium (Cardiovascular System)
         cd31+ cells   
 
 Adipose (Muscoskeletal System)
         Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
 
 Bone (Muscoskeletal System)
         Bone marrow-derived mesenchymal stem cells and monocytes (Ixmyelocel-T)

See IL10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL10

SOURCE GeneReport for Unigene cluster: Hs.193717

UniProtKB/Swiss-Prot: IL10_HUMAN, P22301
Tissue specificity: Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell
types

    SABiosciences Expression via Pathway-Focused PCR Arrays including IL10 (see all 34): 
          Multiple Sclerosis in human mouse rat
          Wound Healing in human mouse rat
          TGFB Signaling Targets in human mouse rat
          Neurotrophins & Receptors in human mouse rat
          Hematopoiesis in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for IL10
OriGene qSTAR qPCR primer pairs in human, mouse for IL10
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IL10
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL10
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL10
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL10

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL10 gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Il101 , 5 interleukin 101, 5 81.09(n)1
73.03(a)1
  1 (56.89 cM)5
161531  NM_010548.21  NP_034678.11 
 1310198455 
chicken
(Gallus gallus)
Aves IL101 interleukin 10 57.84(n)
46.47(a)
  428264  NM_001004414.2  NP_001004414.2 
lizard
(Anolis carolinensis)
Reptilia IL106
Uncharacterized protein
49(a)
1 ↔ 1
GL343228.1(1854207-1864811)
zebrafish
(Danio rerio)
Actinopterygii il101 interleukin 10 47.76(n)
30.99(a)
  553957  NM_001020785.2  NP_001018621.2 


ENSEMBL Gene Tree for IL10 (if available)
TreeFam Gene Tree for IL10 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: IL10_HUMAN, P22301
Polymorphism: A polymorphism in IL10 promoter region is associated with resistance to graft-versus-host disease
(GVHDS) [MIM:614395]. GVHDS is a major complication of allogeneic bone marrow transplantation, in which mature
donor T-cells that contaminate the allogeneic bone marrow recognize the tissues of the recipient as foreign,
causing a severe inflammatory disease


10/187 SNPs in IL10 are shown (see all 187)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0158834
----see VAR_0158832 G R mis40--------
rs120473681,2
--177638849(+) gaggcA/Ggaggt 1 -- ds50010--------
rs412753521,2
C--177638975(+) TTTCTA/GATTTT 1 -- ds50010--------
rs1931208061,2
--177639092(+) CTACTC/GGCTTT 1 -- ds50010--------
rs1855499281,2
--177639136(+) TGGAGC/GCTTCC 1 -- ds50010--------
rs30245001,2
C,F,A--177639157(-) CCCCCT/CACCCC 1 -- ds500114Minor allele frequency- C:0.36NS NA EU WA CSA EA 588
rs1171066521,2
F--177639272(+) AGAACA/TTGATG 1 -- ds50011Minor allele frequency- T:0.01EA 120
rs30244991,2
C,F,H--177639355(-) ATTCAA/GTTCCT 1 -- ut3113Minor allele frequency- G:0.02NS NA EU CSA WA 1068
rs66877861,2
C,F--177639546(+) caggtG/Acgcgc 1 -- ut31 ese34Minor allele frequency- A:0.05NA CSA 54
rs66974971,2
C,A--177639789(+) TCCCTC/TCGAGA 1 -- ut31 ese33Minor allele frequency- T:0.07NA WA 122

HapMap Linkage Disequilibrium report for IL10 (206940947 - 206945839 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for IL10: --

Human Gene Mutation Database (HGMD): IL10
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing IL10
DNA2.0 Custom Variant and Variant Library Synthesis for IL10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 124092   
OMIM disorders: 180300  
20/471 diseases for IL10 (see all 471):    About MalaCards
adult pulmonary langerhans cell histiocytosis    buruli ulcer disease    punctate inner choroidopathy    inflammatory bowel disease 25, early onset, autosomal recessive
leishmaniasis    intraocular lymphoma    panuveitis    indolent b cell lymphoma
rheumatoid arthritis, progression of    visceral leishmaniasis    stenotrophomonas maltophilia    lipoid nephrosis
coronary aneurysm    rheumatoid arthritis    schistosomiasis    paracoccidioidomycosis
chronic active epstein-barr virus infection    miliary tuberculosis    cough variant asthma    eosinophilic fasciitis

18 diseases from the University of Copenhagen DISEASES database for IL10:
Inflammatory bowel disease     Arthritis     Hypersensitivity reaction type II disease     Vascular disease
Leishmaniasis     Connective tissue disease     Multiple sclerosis     Heart disease
Pancreatitis     Tuberculosis     Malaria     Asthma
Lymphoma     Liver disease     Intraocular lymphoma     Hypersensitivity reaction type I disease
Pneumonia     Hepatitis C

IL10 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

10/96 Novoseek inferred disease relationships for IL10 gene (see all 96)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis 91.5 3726 9384233 (7), 11432585 (5), 9127126 (4), 12641520 (4) (see all 99)
inflammation 82.9 558 9753488 (7), 7561121 (5), 9686613 (4), 15637455 (4) (see all 99)
tumors 81.2 3631 7790111 (8), 10454339 (7), 10550371 (6), 8131207 (6) (see all 99)
autoimmune diseases 73.8 91 12220553 (3), 15497451 (2), 15128840 (2), 7933621 (2) (see all 67)
systemic inflammatory response syndrome 70.7 25 11782562 (3), 10446817 (2), 16227031 (2), 10847628 (1) (see all 20)
rheumatoid arthritis 67.3 185 17546224 (5), 11879539 (3), 9227325 (2), 9783765 (2) (see all 99)
multiple sclerosis 67 119 11835372 (4), 7532318 (2), 12220553 (2), 12458048 (2) (see all 83)
sepsis 66.8 236 11421413 (5), 16435103 (4), 16162776 (4), 14642153 (4) (see all 99)
inflammatory bowel diseases 66.5 98 11051278 (3), 9665472 (2), 11907157 (2), 10551422 (2) (see all 64)
autoimmunity 66.5 42 8270873 (2), 20005287 (2), 16118326 (2), 9697995 (2) (see all 29)

Genetic Association Database (GAD): IL10
Human Genome Epidemiology (HuGE) Navigator: IL10 (1177 documents)

Export disorders for IL10 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for IL10 gene, integrated from 9 sources (see all 6590):
(articles sorted by number of sources associating them with IL10)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation. (PubMed id 14657427)1, 2, 4, 9 Lin M.T....Hansen J.A. (2003)
  2. The combination of the interleukin-1alpha (IL-1alpha-889) genotype and the interleukin-10 (IL-10 ATA) haplotype is associated with increased interleukin-10 (IL-10) plasma levels in healthy individuals. (PubMed id 11956022)1, 4, 9 Kilpinen S....Hurme M. (2002)
  3. Interleukin 10 (IL-10) influences autoimmune response in primary Sjogren's syndrome and is linked to IL-10 gene polymorphism. (PubMed id 12233881)1, 4, 9 Anaya J.M....Gallagher G. (2002)
  4. IL-10 promoter -1082 polymorphism is associated with elevated IL-10 levels in control subjects but does not explain elevated plasma IL-10 observed in Sjogren's syndrome in a Hungarian cohort. (PubMed id 16305644)1, 4, 9 Marka M....Semsei I. (2005)
  5. Interleukin-10 and sudden infant death syndrome. (PubMed id 15325406)1, 4, 9 Moscovis S.M....Blackwell C.C. (2004)
  6. Genotype and interleukin-10 responses after cardiopul monary bypass. (PubMed id 12925485)1, 4, 9 Galley H.F....Webster N.R. (2003)
  7. Association between a common IL10 distal promoter hap lotype and IgE production in individuals with atopic dermatitis. (PubMed id 19552724)1, 4, 9 Lacy K....Bidwell J. (2009)
  8. TNFA and IL10 Gene Polymorphisms are not Associated w ith Periodontitis in Brazilians. (PubMed id 19771178)1, 4, 9 Moreira P.R....Dutra W.O. (2009)
  9. Association of IL-10 level and IL-10 promoter SNPs with specific antibodies in penicillin-allergic patients. (PubMed id 17225142)1, 4, 9 Qiao H.L....Jia L.J. (2007)
  10. [Interleukin 10 gene -627 polymorphisms in Chinese patients with early-onset coronary heart disease] (PubMed id 16331571)1, 4, 9 Wang Y.Y....Bao Z.M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3586 HGNC: 5962 AceView: IL10 Ensembl:ENSG00000136634 euGenes: HUgn3586
ECgene: IL10 Kegg: 3586 H-InvDB: IL10

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for IL10 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL10 Genetics and Cytogenetics in Oncology and Haematology
Wikipedia http://en.wikipedia.org/wiki/Interleukin_10
SeattleSNPshttp://pga.gs.washington.edu/data/il10/
SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL10

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for IL10 gene:
Search GeneIP for patents involving IL10

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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