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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IL10 Gene

protein-coding GIFtS: 66
GCID: GC01M206940

interleukin 10

Explore 508 diseases affiliated with
IL10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interleukin 10¹ ²		Cytokine Synthesis Inhibitory Factor² ³
CSIF¹ ² ³ ⁵		GVHDS²
IL-10¹ ² ³		Interleukin-10¹
IL10A¹ ²		T-Cell Growth Inhibitory Factor²
TGIF¹ ²

External Ids:	HGNC: 5962¹	Entrez Gene: 3586²	Ensembl: ENSG00000136634⁷	OMIM: 124092⁵	UniProtKB: P22301³

Export aliases for IL10 gene to outside databases

Previous GC identifers: GC01M205600 GC01M202651 GC01M203584 GC01M204024 GC01M203329 GC01M205007 GC01M177639

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IL10:

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes.

This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1

cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival,

proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation

of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential

immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to

HIV-1 infection and rheumatoid arthritis.(provided by RefSeq, May 2011)

UniProtKB/Swiss-Prot: IL10_HUMAN, P22301

Function: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by

activated macrophages and by helper T-cells

Gene Wiki entry for IL10 (Interleukin 10)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167186.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IL10 gene promoter:
GR Pbx1a Sp1 GR-beta CREB deltaCREB STAT3 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL10 promoter sequence

Search SABiosciences Chromatin IP Primers for IL10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IL10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31-q32 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q31-q32

IL10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL10 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M206940: view genomic region (about GC identifiers)

Start:	206,940,947 bp from pter	End:	206,945,839 bp from pter
Size:	4,893 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IL10_HUMAN, P22301 (See protein sequence)

Recommended Name: Interleukin-10 precursor

Size: 178 amino acids; 20517 Da

Subunit: Homodimer

Subcellular location: Secreted

6/7 PDB 3D structures from and Proteopedia for IL10 (see all 7):

1ILK (3D)

1INR (3D)

1J7V (3D)

1LK3 (3D)

1Y6K (3D)

2H24 (3D)

Explore the universe of human proteins at neXtProt for IL10: NX_P22301

IL10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000563.1

ENSEMBL proteins:

ENSP00000412237

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for IL10 (IL-10)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: IL10 OriGene Custom Protein Services for IL10
	GenScript Purified and Recombinant Proteins for IL10
	Novus Biologicals IL10 Proteins Novus Biologicals IL10 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for IL10
	Uscn Proteins for IL10

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	--	--
GO:0005615	extracellular space	IDA	10443688
GO:0005622	intracellular	--	--

IL10 for ontologies About GeneDecksing

IL10 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of IL10
	R&D Systems Antibodies for IL10 (IL-10)
	OriGene Antibodies (see all 3): IL10 OriGene Custom Antibody Services for IL10
	GenScript Custom Superior Antibodies Services for IL10
	Novus Biologicals IL10 Antibodies
	Abcam antibodies for IL10
	Uscn Antibodies for IL10
	ThermoFisher Antibody for IL10

Assay Products for IL10:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Flow Cytometry Kits for IL10 (IL-10) (see all)
	GenScript Custom Assay Services for IL10
	Enzo Life Sciences assays for IL10
	Uscn ELISAs and CLIAs for IL10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IL10 for domains About GeneDecksing

5 InterPro domains/families:

IPR009079 4_helix_cytokine-like_core

IPR012351 4_helix_cytokine_core

IPR020423 Interleukin-10_CS

IPR020443 Interleukin-10/19/20/24

IPR000098 Interleukin_10

Graphical View of Domain Structure for InterPro Entry P22301

ProtoNet protein and cluster: P22301

1 Blocks protein family: IPB000098 Interleukin-10

UniProtKB/Swiss-Prot: IL10_HUMAN, P22301

Similarity: Belongs to the IL-10 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IL10_HUMAN, P22301

Function: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by

activated macrophages and by helper T-cells

Genatlas biochemistry entry for IL10:

interleukin 10,20.5kDa,cytokine synthesis inhibitory factor,costimulator of proliferation and differentiation of

B,T,mast cell

		10/309 SABiosciences Target genes for IL10 (see all 309):
		ABAT ACPT ACTG1 ACTL8 ADAM30 AIPL1 ALPP ANGPTL5 ANKRD20A1 ANKRD20A2

miRNA Products:		miRTarBase miRNAs that target IL10: hsa-mir-106a (MIRT005082)

		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL10
		8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate IL10 (see all 37):
		hsa-miR-361-5p hsa-let-7d hsa-miR-513a-5p hsa-miR-374a hsa-miR-29b-1* hsa-miR-3916 hsa-let-7g hsa-let-7a

		SwitchGear 3'UTR luciferase reporter plasmid: IL10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL10 (see all 7) OriGene siRNA: IL10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL10

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IL10

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL10 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL10 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL10 (NM_000572)
		Sino Biological Human cDNA Clone for IL10
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL10

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IL10
		Search LifeMap BioReagents cell lines for IL10

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL10

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	NAS	10443688
GO:0005141	interleukin-10 receptor binding	NAS	1847510
GO:0008083	growth factor activity	NAS	1371884

IL10 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for IL10:

Decreased viability with pacli

Animal Models:
Mouse knock-outs for IL10: Il10^tm1.1Roer Il10^tm1Cgn
15/24 MGI mutant phenotypes (inferred from 11 alleles) (MGI details for Il10) (see all 24):

behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging

IL10 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

8/12 pathways (see all 12)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

TGF-Beta Pathway

TGF-Beta Pathway	1.00	Regulation of eIF4 and p70S6K	0.43
MAPK Family Pathway	0.60	SOCS Pathway	0.29
JAK-STAT Pathway	0.57

Allograft rejection

Allograft rejection	1.00	THC Differentiation Pathway	0.39
Autoimmune thyroid disease	0.60	Intestinal immune network for IgA production	0.38
Asthma	0.44

Akt Signaling

	Akt Signaling	1.00			Tec Kinases Signaling	0.55
	p38 Signaling	0.60

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for IL10

	Immune response IL-10 signaling pathway
	Apoptosis and survival APRIL and BAFF signaling

2 R&D Systems Pathways for IL10

	Th1 Differentiation
	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IL10 (see all 28)

	THC Differentiation Pathway
	Endothelin-1 Signaling Pathway
	IL-10 Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C

2 GeneGo (Thomson Reuters) Pathways for IL10

	Apoptosis and survival APRIL and BAFF signaling
	Immune response IL-10 signaling pathway

4 BioSystems Pathways for IL10

	Cytokines and Inflammatory Response
	SIDS Susceptibility Pathways
	IL4-mediated signaling events
	Regulation of nuclear SMAD2/3 signaling

5/17 Kegg Pathways (Kegg details for IL10) (see all 17):

	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway
	T cell receptor signaling pathway
	Intestinal immune network for IgA production
	Pertussis

IL10 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IL10

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/18 Interacting proteins for IL10 (P22301^{2, 3} ENSP00000412237⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL10RA	Q13651²^,³, ENSP00000227752⁴	MINT-24888 I2D: score=6 STRING: ENSP00000227752
IL10RB	Q08334³, ENSP00000290200⁴	I2D: score=2 STRING: ENSP00000290200
A2M	P01023³, ENSP00000323929⁴	I2D: score=2 STRING: ENSP00000323929
TLR4	O00206³, ENSP00000363089⁴	I2D: score=1 STRING: ENSP00000363089
IFNAR2	P48551³	I2D: score=1

About this table

Gene Ontology (GO): 5/51 biological process terms (GO ID links to tree view) (see all 51): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001818	negative regulation of cytokine production	--	--
GO:0002237	response to molecule of bacterial origin	IDA	17449476
GO:0002740	negative regulation of cytokine secretion involved in immune response	IDA	10443688
GO:0002875	negative regulation of chronic inflammatory response to antigenic stimulus	IEA	--
GO:0002904	positive regulation of B cell apoptotic process	IDA	9184696

IL10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IL10 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IL10
10/132 Novoseek chemical compound relationships for IL10 gene (see all 132) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
il 10	94.6	1439	16331571 (7), 19771178 (7), 12394188 (7), 16954457 (7) (see all 99)
rantes	79.9	287	10048682 (5), 16911685 (5), 17460443 (5), 17015691 (4) (see all 99)
il-12	72.4	47	11479428 (3), 11403227 (3), 17324967 (2), 18508030 (2) (see all 36)
endotoxin	67.9	214	7561121 (8), 15637455 (6), 11176172 (5), 12566670 (4) (see all 99)
pge2	63.7	390	9002960 (6), 15219461 (6), 8018602 (6), 12496396 (5) (see all 99)
ammonium trichloro(dioxoethylene-o,o')tellurate	63.1	3	20100863 (1), 14996748 (1)
ionomycin	61.6	54	16265694 (2), 9518518 (2), 18023089 (2), 10674971 (1) (see all 48)
allergens	58.3	40	16238790 (2), 11564436 (2), 12731045 (2), 9590218 (1) (see all 30)
neopterin	58.1	80	8844339 (4), 15284959 (3), 9339750 (3), 11051235 (3) (see all 46)
ccl3	57.7	24	20041183 (2), 16501053 (1), 18239321 (1), 14578205 (1) (see all 18)

Search CenterWatch for drugs/clinical trials and news about IL10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IL10 gene:

NM_000572.2

Unigene Cluster for IL10:

Interleukin 10

Hs.193717 [show with all ESTs]

Unigene Representative Sequence: BC022315

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000423557(uc001hen.1) ENST00000471071 ENST00000367099

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IL10
		8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate IL10 (see all 37):
		hsa-miR-361-5p hsa-let-7d hsa-miR-513a-5p hsa-miR-374a hsa-miR-29b-1* hsa-miR-3916 hsa-let-7g hsa-let-7a

		SwitchGear 3'UTR luciferase reporter plasmid: IL10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IL10 (see all 7) OriGene siRNA: IL10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IL10

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IL10 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IL10 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: IL10 (NM_000572)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL10

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL10
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL10

Additional cDNA sequence:

AF043333.1 AY029171.1 BC022315.1 BC104252.1 BC104253.1 CR541993.1 CR542028.1 EU751618.2

EU751619.2 M57627.1

2 DOTS entries:

DT.207856 DT.40106255

14 AceView cDNA sequences:

CR541993 AF043333 CD369014 CA308268 NM_000572 AY029171 M57627 AA382010

CR542028 CD641785 BC022315 T29794 AW951607 BG538741

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IL10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See IL10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IL10

SOURCE GeneReport for Unigene cluster: Hs.193717

UniProtKB/Swiss-Prot: IL10_HUMAN, P22301

Tissue specificity: Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell

types

SABiosciences Expression via Pathway-Focused PCR Arrays including IL10 (see all 34):

Multiple Sclerosis in human mouse rat

Wound Healing in human mouse rat

TGFB Signaling Targets in human mouse rat

Neurotrophins & Receptors in human mouse rat

Hematopoiesis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IL10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IL10
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IL10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IL10

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IL10 gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Il10^{1 , 5}	interleukin 10^{1, 5}	81.09(n)¹ 73.03(a)¹		1 (56.89 cM)⁵ 16153¹ NM_010548.2¹ NP_034678.1¹ 131019845⁵
chicken (Gallus gallus)	Aves	IL10¹	interleukin 10	57.84(n) 46.47(a)		428264 NM_001004414.2 NP_001004414.2
lizard (Anolis carolinensis)	Reptilia	IL10⁶	--	49(a)	1 ↔ 1	GL343228.1(1854721-1864773)
zebrafish (Danio rerio)	Actinopterygii	il10¹	interleukin 10	47.76(n) 30.99(a)		553957 NM_001020785.2 NP_001018621.2

ENSEMBL Gene Tree for IL10 (if available)
TreeFam Gene Tree for IL10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: IL10_HUMAN, P22301

Polymorphism: A polymorphism in IL10 promoter region is associated with resistance to graft-versus-host disease (GVHDS)

[MIM:614395]. GVHDS is a major complication of allogeneic bone marrow transplantation, in which mature donor T-cells

that contaminate the allogeneic bone marrow recognize the tissues of the recipient as foreign, causing a severe

inflammatory disease

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3024499^1,2	C,F,H,	--	177639355(-)	`ATTCAA/GTTCCT`	1	--	ut3¹		13		NS NA EU CSA WA	1068
rs6687786^1,2	C,	--	177639546(+)	`caggtG/Acgcgc`	1	--	ut3¹ ese³		4		NA CSA	54
rs6697497^1,2	C,A,	--	177639789(+)	`TCCCTC/TCGAGA`	1	--	ut3¹ ese³		3		NA WA	122
rs3024498^1,2	C,F,O,H,	--	177639855(-)	`CTGCTA/GCAAAT`	1	--	ut3¹ ese³		44		NS NA EU EA MN WA	6010
rs3024510^1,2	C,F,	--	177639962(-)	`AGCCAA/TCAGAA`	1	--	ut3¹ ese³		16		NS NA EU MN	1256
rs3024497^1,2	C,F,H,	--	177640116(-)	`GATTTA/GGAAAG`	1	--	ut3¹		19		NS EA NA EU MN WA	1262
rs142093260^1,2	C,	--	177640334(+)	`ATGTAG/TGNNNN`	2	A	syn¹		0	--	--	--	--
rs45587633^1,2	C,F,	--	177640513(-)	`TGAGGG/AAGAAC`	1	--	int¹		2		MN NA	660
rs45611331^1,2	C,F,	--	177640570(-)	`NNNNTG/ACACAG`	1	--	int¹		2		MN NA	662
rs79782619^1,2		--	177640581(+)	`CCTTCA/GTCTCC`	1	--	int¹		1		NA	120

HapMap Linkage Disequilibrium report for IL10 (206940947 - 206945839 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IL10
1 CNV: 2091
Human Gene Mutation Database (HGMD): IL10

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IL10

DNA2.0 Custom Variant and Variant Library Synthesis for IL10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IL10 for disorders           About GeneDecksing

OMIM gene information: 124092
OMIM disorders: 180300
20/508 diseases for IL10 (see all 508):    About MalaCards

graft-versus-host disease, protection against rheumatoid arthritis graft versus host disease chronic active epstein-barr virus infection

punctate inner choroidopathy african tick-bite fever lambert-eaton myasthenic syndrome post-transplant lymphoproliferative disease

arthritis alpha 1-antitrypsin deficiency stenotrophomonas maltophilia spinal cord injury

mycobacterium avium complex disease large granular lymphocyte leukemia relapsing-remitting multiple sclerosis b-cell non-hodgkin lymphoma

lumbar disc degeneration chloride diarrhea hyper-ige syndrome churg-strauss syndrome

17 diseases from the University of Copenhagen DISEASES database for IL10:

Inflammatory bowel disease Arthritis Vascular disease Leishmaniasis

Systemic lupus erythematosus Pancreatitis Heart disease Multiple sclerosis

Malaria Asthma Tuberculosis Lymphoma

Liver disease Pneumonia Hypersensitivity reaction type I disease Intraocular lymphoma

Hepatitis C

10/96 Novoseek disease relationships for IL10 gene (see all 96) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	91.5	3726	9384233 (7), 11432585 (5), 9127126 (4), 12641520 (4) (see all 99)
inflammation	82.9	558	9753488 (7), 7561121 (5), 9686613 (4), 15637455 (4) (see all 99)
tumors	81.2	3631	7790111 (8), 10454339 (7), 10550371 (6), 8131207 (6) (see all 99)
autoimmune diseases	73.8	91	12220553 (3), 15497451 (2), 15128840 (2), 7933621 (2) (see all 67)
systemic inflammatory response syndrome	70.7	25	11782562 (3), 10446817 (2), 16227031 (2), 10847628 (1) (see all 20)
rheumatoid arthritis	67.3	185	17546224 (5), 11879539 (3), 9227325 (2), 9783765 (2) (see all 99)
multiple sclerosis	67	119	11835372 (4), 7532318 (2), 12220553 (2), 12458048 (2) (see all 83)
sepsis	66.8	236	11421413 (5), 16435103 (4), 16162776 (4), 14642153 (4) (see all 99)
inflammatory bowel diseases	66.5	98	11051278 (3), 9665472 (2), 11907157 (2), 10551422 (2) (see all 64)
autoimmunity	66.5	42	8270873 (2), 20005287 (2), 16118326 (2), 9697995 (2) (see all 29)

Genetic Association Database (GAD): IL10
Human Genome Epidemiology (HuGE) Navigator: IL10 (1177 documents)

Export disorders for IL10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IL10 gene, integrated from 9 sources (see all 6474):
(articles sorted by number of sources associating them with IL10)

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Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation. (PubMed id 14657427)^{1, 2, 4, 9} Lin M.T....Hansen J.A. (2003)
The combination of the interleukin-1alpha (IL-1alpha-889) genotype and the interleukin-10 (IL-10 ATA) haplotype is associated with increased interleukin-10 (IL-10) plasma levels in healthy individuals. (PubMed id 11956022)^{1, 4, 9} Kilpinen S....Hurme M. (2002)
Genotype and interleukin-10 responses after cardiopul monary bypass. (PubMed id 12925485)^{1, 4, 9} Galley H.F....Webster N.R. (2003)
[Interleukin 10 gene -627 polymorphisms in Chinese patients with early-onset coronary heart disease] (PubMed id 16331571)^{1, 4, 9} Wang Y.Y....Bao Z.M. (2005)
A Gly15Arg mutation in the interleukin-10 gene reduces secretion of interleukin-10 in Crohn disease. (PubMed id 12825869)^{1, 2, 9} van der Linde K.... de Rooij F.W. (2003)
Interleukin-10, interleukin-6 and interferon-gamma gene polymorphisms in melanoma patients. (PubMed id 12394188)^{1, 4, 9} Martinez-Escribano J.A....Alvarez-Lopez M.R. (2002)
[Correlation between polymorphism of IL-4 and IL-10 gene promoter and childhood asthma and their impact upon cytokine expression] (PubMed id 11953141)^{1, 4, 9} Zhang J....Chen Y. (2002)
Interleukin-10 and interleukin-18 promoter polymorphisms in an Italian cohort of patients with undifferentiated carcinoma of nasopharyngeal type. (PubMed id 16059673)^{1, 4, 9} Pratesi C....De Paoli P. (2006)
Polymorphisms of complement receptor 1 and interleukin-10 genes and systemic lupus erythematosus: a meta-analysis. (PubMed id 16133175)^{1, 4, 9} Nath S.K....Lee Y.H. (2005)
Non-Hodgkin's B cell lymphoma in persons with acquired immunodeficiency syndrome is associated with increased serum levels of IL10, or the IL10 promoter -592 C/C genotype. (PubMed id 14597210)^{1, 4, 9} Breen E.C....Martinez-Maza O. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3586	HGNC: 5962	AceView: IL10	Ensembl:ENSG00000136634	euGenes: HUgn3586
ECgene: IL10	Kegg: 3586	H-InvDB: IL10

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IL10	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for IL10	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Interleukin_10
SeattleSNPs	http://pga.gs.washington.edu/data/il10/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL10

Intellectual Property for IL10 gene
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Patent Information for IL10 gene:
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GeneCards and IP:
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IMMUNE DISORDER
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IL10 Gene

interleukin 10

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