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Aliases for IL10 Gene

Aliases for IL10 Gene

  • Interleukin 10 2 3
  • Cytokine Synthesis Inhibitory Factor 2 3 4
  • CSIF 3 4 6
  • T-Cell Growth Inhibitory Factor 2 3
  • GVHDS 3 6
  • IL-10 3 4
  • Interleukin-10 3
  • IL10A 3
  • TGIF 3

External Ids for IL10 Gene

Previous GeneCards Identifiers for IL10 Gene

  • GC01M205600
  • GC01M202651
  • GC01M203584
  • GC01M204024
  • GC01M203329
  • GC01M205007
  • GC01M206940
  • GC01M177639

Summaries for IL10 Gene

Entrez Gene Summary for IL10 Gene

  • The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]

GeneCards Summary for IL10 Gene

IL10 (Interleukin 10) is a Protein Coding gene. Diseases associated with IL10 include rheumatoid arthritis and graft-versus-host disease, protection against. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include cytokine activity and interleukin-10 receptor binding.

UniProtKB/Swiss-Prot for IL10 Gene

  • Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells

Gene Wiki entry for IL10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL10 Gene

Genomics for IL10 Gene

Regulatory Elements for IL10 Gene

Genomic Location for IL10 Gene

206,767,602 bp from pter
206,772,494 bp from pter
4,893 bases
Minus strand

Genomic View for IL10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL10 Gene

Proteins for IL10 Gene

  • Protein details for IL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:

    Protein attributes for IL10 Gene

    178 amino acids
    Molecular mass:
    20517 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for IL10 Gene

neXtProt entry for IL10 Gene

Proteomics data for IL10 Gene at MOPED

Post-translational modifications for IL10 Gene

Other Protein References for IL10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IL10 (IL10)

No data available for DME Specific Peptides for IL10 Gene

Domains for IL10 Gene

Gene Families for IL10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IL-10 family.
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL10: view

Function for IL10 Gene

Molecular function for IL10 Gene

GENATLAS Biochemistry:
interleukin 10,20.5kDa,cytokine synthesis inhibitory factor,costimulator of proliferation and differentiation of B,T,mast cell
UniProtKB/Swiss-Prot Function:
Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells

Gene Ontology (GO) - Molecular Function for IL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity NAS 10443688
GO:0005141 interleukin-10 receptor binding NAS 1847510
GO:0008083 growth factor activity NAS 1371884
genes like me logo Genes that share ontologies with IL10: view
genes like me logo Genes that share phenotypes with IL10: view

Animal Models for IL10 Gene

MGI Knock Outs for IL10:

Animal Model Products

miRNA for IL10 Gene

miRTarBase miRNAs that target IL10

Transcription Factor Targets for IL10 Gene

Selected GeneGlobe predicted Target genes for IL10

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for IL10 Gene

Localization for IL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL10 Gene


Subcellular locations from

Jensen Localization Image for IL10 Gene COMPARTMENTS Subcellular localization image for IL10 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 10443688
genes like me logo Genes that share ontologies with IL10: view

Pathways for IL10 Gene

genes like me logo Genes that share pathways with IL10: view

PCR Array Products

Gene Ontology (GO) - Biological Process for IL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001818 negative regulation of cytokine production --
GO:0002237 response to molecule of bacterial origin IDA 17449476
GO:0002740 negative regulation of cytokine secretion involved in immune response IDA 10443688
GO:0002875 negative regulation of chronic inflammatory response to antigenic stimulus IEA --
GO:0002904 positive regulation of B cell apoptotic process IDA 9184696
genes like me logo Genes that share ontologies with IL10: view

Drugs for IL10 Gene

(3) Drugbank Compounds for IL10 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Target investigational
Target investigational
Target investigational

(132) Novoseek inferred chemical compound relationships for IL10 Gene

Compound -log(P) Hits PubMed IDs
il 10 94.6 458
rantes 79.9 161
il-12 72.4 42
endotoxin 67.9 148
pge2 63.7 192

(4) PharmGKB related drug/compound annotations for IL10 Gene

genes like me logo Genes that share compounds with IL10: view

Transcripts for IL10 Gene

mRNA/cDNA for IL10 Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL10 Gene

Interleukin 10:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL10 Gene

No ASD Table

Relevant External Links for IL10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL10 Gene

mRNA expression in normal human tissues for IL10 Gene

mRNA differential expression in normal tissues according to GTEx for IL10 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (6.3), Whole Blood (6.1), and Spleen (5.0).

Protein differential expression in normal tissues for IL10 Gene

This gene is overexpressed in Tlymphocyte (68.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL10 Gene

SOURCE GeneReport for Unigene cluster for IL10 Gene Hs.193717

mRNA Expression by UniProt/SwissProt for IL10 Gene

Tissue specificity: Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types
genes like me logo Genes that share expressions with IL10: view

Expression partners for IL10 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for IL10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IL10 35
  • 84.56 (n)
  • 77.4 (a)
IL10 36
  • 75 (a)
(Canis familiaris)
Mammalia IL10 35
  • 83.43 (n)
  • 77.97 (a)
IL10 36
  • 80 (a)
(Mus musculus)
Mammalia Il10 35
  • 81.09 (n)
  • 73.03 (a)
Il10 16
Il10 36
  • 73 (a)
(Pan troglodytes)
Mammalia IL10 35
  • 99.63 (n)
  • 99.44 (a)
IL10 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Il10 35
  • 82.21 (n)
  • 73.6 (a)
(Monodelphis domestica)
Mammalia IL10 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia IL10 36
  • 52 (a)
(Gallus gallus)
Aves IL10 35
  • 57.89 (n)
  • 46.2 (a)
IL10 36
  • 46 (a)
(Anolis carolinensis)
Reptilia IL10 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia il10 35
  • 59.1 (n)
  • 50.31 (a)
(Danio rerio)
Actinopterygii il10 35
  • 47.78 (n)
  • 30.64 (a)
il10 36
  • 30 (a)
Species with no ortholog for IL10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL10 Gene

Gene Tree for IL10 (if available)
Gene Tree for IL10 (if available)

Paralogs for IL10 Gene

No data available for Paralogs for IL10 Gene

Variants for IL10 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IL10 Gene

A polymorphism in IL10 promoter region is associated with resistance to graft-versus-host disease (GVHDS) [MIM:614395]. GVHDS is a major complication of allogeneic bone marrow transplantation, in which mature donor T-cells that contaminate the allogeneic bone marrow recognize the tissues of the recipient as foreign, causing a severe inflammatory disease

Sequence variations from dbSNP and Humsavar for IL10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs575873427 -- 206,769,973(+) GGTGG(C/G)ATCAT intron-variant
rs575853731 -- 206,769,002(+) GTCAC(A/G)TATTC intron-variant
rs575320961 -- 206,767,666(+) ACAAT(A/G)TAACA utr-variant-3-prime
rs575113742 -- 206,768,189(+) TAGCA(A/G)TTAGG utr-variant-3-prime
rs574602524 -- 206,771,897(+) GAAAC(A/G)CTCTA intron-variant

Relevant External Links for IL10 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Structural Variations from Database of Genomic Variants (DGV) for IL10 Gene

Disorders for IL10 Gene

(3) OMIM Diseases for IL10 Gene (124092)

(96) Novoseek inferred disease relationships for IL10 Gene

Disease -log(P) Hits PubMed IDs
necrosis 91.5 227
inflammation 82.9 161
tumors 81.2 290
autoimmune diseases 73.8 75
systemic inflammatory response syndrome 70.7 24

Relevant External Links for IL10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IL10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL10 Gene

Publications for IL10 Gene

  1. Relation of an interleukin-10 promoter polymorphism to graft-versus- host disease and survival after hematopoietic-cell transplantation. (PMID: 14657427) Lin M.T. … Hansen J.A. (N. Engl. J. Med. 2003) 3 4 23 48
  2. Polymorphisms in the interleukin-10 and interferon gamma genes in Hodgkin lymphoma. (PMID: 14959851) Munro L.R. … Vickers M.A. (Leuk. Lymphoma 2003) 3 23 48
  3. Interleukin-10 or tumor necrosis factor-alpha polymorphisms and the natural course of hepatitis C virus infection in a hyperendemic area of Japan. (PMID: 16698276) Kusumoto K. … Tsubouchi H. (Cytokine 2006) 3 23 48
  4. Polymorphism in promoter region of IL10 gene is associated with rheumatoid arthritis in women. (PMID: 14994383) Padyukov L. … Klareskog L. (J. Rheumatol. 2004) 3 23 48
  5. Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis. (PMID: 16804000) Crivello A. … Caruso C. (Ann. N. Y. Acad. Sci. 2006) 3 23 48

Products for IL10 Gene

Sources for IL10 Gene

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