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Aliases for IL10 Gene

Aliases for IL10 Gene

  • Interleukin 10 2 3 5
  • Cytokine Synthesis Inhibitory Factor 2 3 4
  • T-Cell Growth Inhibitory Factor 2 3
  • IL-10 3 4
  • CSIF 3 4
  • GVHDS 3
  • IL10A 3
  • TGIF 3

External Ids for IL10 Gene

Previous GeneCards Identifiers for IL10 Gene

  • GC01M205600
  • GC01M202651
  • GC01M203584
  • GC01M204024
  • GC01M203329
  • GC01M205007
  • GC01M206940
  • GC01M177639

Summaries for IL10 Gene

Entrez Gene Summary for IL10 Gene

  • The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]

GeneCards Summary for IL10 Gene

IL10 (Interleukin 10) is a Protein Coding gene. Diseases associated with IL10 include Graft-Versus-Host Disease, Protection Against and Rheumatoid Arthritis. Among its related pathways are IL4-mediated signaling events and ERK Signaling. GO annotations related to this gene include cytokine activity and interleukin-10 receptor binding.

UniProtKB/Swiss-Prot for IL10 Gene

  • Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

Gene Wiki entry for IL10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL10 Gene

Genomics for IL10 Gene

Regulatory Elements for IL10 Gene

Enhancers for IL10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IL10 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL10 Gene

Chromosome:
1
Start:
206,767,602 bp from pter
End:
206,774,607 bp from pter
Size:
7,006 bases
Orientation:
Minus strand

Genomic View for IL10 Gene

Genes around IL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL10 Gene

Proteins for IL10 Gene

  • Protein details for IL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22301-IL10_HUMAN
    Recommended name:
    Interleukin-10
    Protein Accession:
    P22301

    Protein attributes for IL10 Gene

    Size:
    178 amino acids
    Molecular mass:
    20517 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for IL10 Gene

neXtProt entry for IL10 Gene

Proteomics data for IL10 Gene at MOPED

Post-translational modifications for IL10 Gene

Other Protein References for IL10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IL10 (IL10)
  • Abcam antibodies for IL10

No data available for DME Specific Peptides for IL10 Gene

Domains & Families for IL10 Gene

Gene Families for IL10 Gene

Graphical View of Domain Structure for InterPro Entry

P22301

UniProtKB/Swiss-Prot:

IL10_HUMAN :
  • Belongs to the IL-10 family.
Family:
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL10: view

Function for IL10 Gene

Molecular function for IL10 Gene

GENATLAS Biochemistry:
interleukin 10,20.5kDa,cytokine synthesis inhibitory factor,costimulator of proliferation and differentiation of B,T,mast cell
UniProtKB/Swiss-Prot Function:
Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

Gene Ontology (GO) - Molecular Function for IL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11485736
genes like me logo Genes that share ontologies with IL10: view
genes like me logo Genes that share phenotypes with IL10: view

Human Phenotype Ontology for IL10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL10 Gene

MGI Knock Outs for IL10:

Animal Model Products

Transcription Factor Targets for IL10 Gene

Selected GeneGlobe predicted Target genes for IL10

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for IL10 Gene

Localization for IL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL10 Gene COMPARTMENTS Subcellular localization image for IL10 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
mitochondrion 2
plasma membrane 2
vacuole 2
endosome 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for IL10 Gene

Pathways & Interactions for IL10 Gene

genes like me logo Genes that share pathways with IL10: view

SIGNOR curated interactions for IL10 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002237 response to molecule of bacterial origin IDA 17449476
GO:0002740 negative regulation of cytokine secretion involved in immune response IDA 10443688
GO:0002875 negative regulation of chronic inflammatory response to antigenic stimulus IEA --
GO:0002904 positive regulation of B cell apoptotic process IDA 9184696
GO:0006954 inflammatory response IDA 10443688
genes like me logo Genes that share ontologies with IL10: view

Drugs & Compounds for IL10 Gene

(105) Drugs for IL10 Gene - From: DrugBank, PharmGKB, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR, Cytotoxic agent 1466
Mycophenolate mofetil Approved, Investigational Pharma IMPDH inhibitor 906
Tacrolimus Approved, Investigational Pharma 1045
Cyclosporine Approved, Investigational Pharma Immunosuppressant drug 0
Efavirenz Approved, Investigational Pharma Reverse transcriptase inhibitor 404

(53) Additional Compounds for IL10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL10: view

Transcripts for IL10 Gene

mRNA/cDNA for IL10 Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL10 Gene

Interleukin 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL10 Gene

No ASD Table

Relevant External Links for IL10 Gene

GeneLoc Exon Structure for
IL10
ECgene alternative splicing isoforms for
IL10

Expression for IL10 Gene

mRNA expression in normal human tissues for IL10 Gene

mRNA differential expression in normal tissues according to GTEx for IL10 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x6.3), Whole Blood (x6.1), and Spleen (x5.0).

Protein differential expression in normal tissues from HIPED for IL10 Gene

This gene is overexpressed in Tlymphocyte (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL10 Gene



SOURCE GeneReport for Unigene cluster for IL10 Gene Hs.193717

mRNA Expression by UniProt/SwissProt for IL10 Gene

P22301-IL10_HUMAN
Tissue specificity: Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.
genes like me logo Genes that share expression patterns with IL10: view

Protein tissue co-expression partners for IL10 Gene

Primer Products

Orthologs for IL10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IL10 35
  • 84.56 (n)
  • 77.4 (a)
IL10 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL10 35
  • 83.43 (n)
  • 77.97 (a)
IL10 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il10 35
  • 81.09 (n)
  • 73.03 (a)
Il10 16
Il10 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IL10 35
  • 99.63 (n)
  • 99.44 (a)
IL10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il10 35
  • 82.21 (n)
  • 73.6 (a)
oppossum
(Monodelphis domestica)
Mammalia IL10 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL10 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL10 35
  • 57.89 (n)
  • 46.2 (a)
IL10 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL10 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il10 35
  • 59.1 (n)
  • 50.31 (a)
zebrafish
(Danio rerio)
Actinopterygii il10 35
  • 47.78 (n)
  • 30.64 (a)
il10 36
  • 30 (a)
OneToOne
Species with no ortholog for IL10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL10 Gene

ENSEMBL:
Gene Tree for IL10 (if available)
TreeFam:
Gene Tree for IL10 (if available)

Paralogs for IL10 Gene

No data available for Paralogs for IL10 Gene

Variants for IL10 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IL10 Gene

IL10_HUMAN-P22301
A polymorphism in IL10 promoter region is associated with resistance to graft-versus-host disease (GVHDS) [MIM:614395]. GVHDS is a major complication of allogeneic bone marrow transplantation, in which mature donor T-cells that contaminate the allogeneic bone marrow recognize the tissues of the recipient as foreign, causing a severe inflammatory disease.

Sequence variations from dbSNP and Humsavar for IL10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_015883 -
rs1554286 -- 206,770,888(-) CAGTT(C/T)TTTCC intron-variant
rs1518110 -- 206,771,516(-) AATTT(G/T)ATTTA intron-variant
rs1518111 -- 206,771,300(-) GGGAG(A/G)CTCTG intron-variant
rs1878672 -- 206,770,368(-) ATGCC(C/G/T)TCACT intron-variant

Variation tolerance for IL10 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL10 Gene

Human Gene Mutation Database (HGMD)
IL10

No data available for Structural Variations from Database of Genomic Variants (DGV) for IL10 Gene

Disorders for IL10 Gene

MalaCards: The human disease database

(202) MalaCards diseases for IL10 Gene - From: OMIM, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
graft-versus-host disease, protection against
  • graft versus host disease
rheumatoid arthritis
  • rheumatoid arthritis, progression of
hiv-1
  • aids, slow progression to
paracoccidioidomycosis
  • mucocutaneous-lymphangitic paracoccidioidomycosis
leishmaniasis
  • cutaneous leishmaniasis
- elite association - COSMIC cancer census association via MalaCards
Search IL10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL10

Genetic Association Database (GAD)
IL10
Human Genome Epidemiology (HuGE) Navigator
IL10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL10
genes like me logo Genes that share disorders with IL10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL10 Gene

Publications for IL10 Gene

  1. Relation of an interleukin-10 promoter polymorphism to graft-versus- host disease and survival after hematopoietic-cell transplantation. (PMID: 14657427) Lin M.T. … Hansen J.A. (N. Engl. J. Med. 2003) 3 4 48 67
  2. Polymorphism in the IL10 promoter region and early markers of atherosclerosis: the Cardiovascular Risk in Young Finns Study. (PMID: 19700159) Heiskanen M. … Hulkkonen J. (Atherosclerosis 2010) 3 23
  3. Interleukin-6 leads to interleukin-10 production in several human multiple myeloma cell lines. Does interleukin-10 enhance the proliferation of these cells? (PMID: 19762082) Kovacs E. (Leuk. Res. 2010) 3 23
  4. Interaction among variant vascular endothelial growth factor (VEGF) and its receptor in relation to prostate cancer risk. (PMID: 19908237) VanCleave T.T. … Kidd L.C. (Prostate 2010) 3 23
  5. Impact of genomic risk factors on outcome after hematopoietic stem cell transplantation for patients with chronic myeloid leukemia. (PMID: 20305143) Dickinson A.M. … Gratwohl A. (Haematologica 2010) 3 23

Products for IL10 Gene

Sources for IL10 Gene

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