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IL10 Gene

protein-coding   GIFtS: 66
GCID: GC01M206940

Interleukin 10

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interleukin 101 2     GVHDS2 5
Cytokine Synthesis Inhibitory Factor1 2 3     IL10A2
CSIF2 3 5     TGIF2
T-Cell Growth Inhibitory Factor1 2     interleukin-102
IL-102 3     

External Ids:    HGNC: 59621   Entrez Gene: 35862   Ensembl: ENSG000001366347   OMIM: 1240925   UniProtKB: P223013   

Export aliases for IL10 gene to outside databases

Previous GC identifers: GC01M205600 GC01M202651 GC01M203584 GC01M204024 GC01M203329 GC01M205007 GC01M177639


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IL10 Gene:
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by
lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the
expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B
cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is
involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of
this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with
an increased susceptibility to HIV-1 infection and rheumatoid arthritis.(provided by RefSeq, May 2011)

GeneCards Summary for IL10 Gene:
IL10 (interleukin 10) is a protein-coding gene. Diseases associated with IL10 include rheumatoid arthritis, progression of, and hiv-1. GO annotations related to this gene include interleukin-10 receptor binding and cytokine activity.

UniProtKB/Swiss-Prot: IL10_HUMAN, P22301
Function: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF
produced by activated macrophages and by helper T-cells

Gene Wiki entry for IL10 (Interleukin 10) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the IL10 gene promoter:
         GR   Pbx1a   Sp1   GR-beta   CREB   deltaCREB   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IL10 promoter sequence
   Search Chromatin IP Primers for IL10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IL10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31-q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q31-q32

IL10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IL10 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M206940:  view genomic region     (about GC identifiers)

Start:
206,940,947 bp from pter      End:
206,945,839 bp from pter
Size:
4,893 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IL10_HUMAN, P22301 (See protein sequence)
Recommended Name: Interleukin-10 precursor  
Size: 178 amino acids; 20517 Da
Subunit: Homodimer
Selected PDB 3D structures from and Proteopedia for IL10 (see all 7):
1ILK (3D)        1INR (3D)        1J7V (3D)        1LK3 (3D)        1Y6K (3D)        2H24 (3D)    

Explore the universe of human proteins at neXtProt for IL10: NX_P22301

Explore proteomics data for IL10 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn134

  • See IL10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000563.1  
    ENSEMBL proteins: 
     ENSP00000412237  

    IL10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IL10 (IL-10)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IL10
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IL10
    GenScript Purified and Recombinant Proteins for IL10
    Novus Biologicals IL10 Proteins
    Novus Biologicals IL10 Lysates
    Sino Biological Recombinant Protein for IL10
    Sino Biological Cell Lysate for IL10
    ProSpec Recombinant Protein for IL10
    Cloud-Clone Corp. Proteins for IL10

    IL10 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IL10
    R&D Systems Antibodies for IL10 (IL-10)
    Cell Signaling Technology (CST) Antibodies for IL10 
    OriGene Antibodies for IL10
    OriGene Custom Antibody Services for IL10
    Novus Biologicals IL10 Antibodies
    Abcam antibodies for IL10
    Cloud-Clone Corp. Antibodies for IL10
    ThermoFisher Antibody for IL10
    LSBio Antibodies in human, mouse, rat for IL10

    IL10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IL10
    R&D Systems Flow Cytometry Kits for IL10 (IL-10)         (see all)
    GenScript Custom Assay Services for IL10
    Enzo Life Sciences assays for IL10
    Cloud-Clone Corp. ELISAs for IL10
    Cloud-Clone Corp. CLIAs for IL10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IL: Interleukins and interleukin receptors

    5 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR020423 IL-10_CS
     IPR009079 4_helix_cytokine-like_core
     IPR020443 IL-10/19/20/24/26_fam
     IPR000098 IL-10

    Graphical View of Domain Structure for InterPro Entry P22301

    ProtoNet protein and cluster: P22301

    1 Blocks protein domain: IPB000098 Interleukin-10

    UniProtKB/Swiss-Prot: IL10_HUMAN, P22301
    Similarity: Belongs to the IL-10 family


    IL10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IL10_HUMAN, P22301
    Function: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF
    produced by activated macrophages and by helper T-cells

         Genatlas biochemistry entry for IL10:
    interleukin 10,20.5kDa,cytokine synthesis inhibitory factor,costimulator of proliferation and differentiation of
    B,T,mast cell

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity NAS10443688
    GO:0005141interleukin-10 receptor binding NAS1847510
    GO:0008083growth factor activity NAS1371884
         
    IL10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IL10:
     Decreased viability with pacli 

         Selected MGI mutant phenotypes (inferred from 11 alleles(MGI details for Il10) (see all 24):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 

    IL10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IL10: Il10tm1.1Roer Il10tm1Cgn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IL10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IL10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IL10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IL10

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for IL10 (see all 297):
    ABAT,  ACPT,  ACTG1,  ACTL8,  ADAM30,  AIPL1,  ALPP,  ANGPTL5,  ANKRD20A1,  ANKRD20A2

    miRNA
    Products:
        
    miRTarBase miRNAs that target IL10:
    hsa-mir-106a-5p (MIRT005082)

    Block miRNA regulation of human, mouse, rat IL10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL10 (see all 37):
    hsa-miR-361-5p hsa-let-7d hsa-miR-513a-5p hsa-miR-374a hsa-miR-29b-1* hsa-miR-3916 hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidIL10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IL10
    Predesigned siRNA for gene silencing in human, mouse, rat IL10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IL10

    Clone
    Products:
         
    OriGene clones in human, mouse for IL10 (see all 5)
    OriGene ORF clones in mouse, rat for IL10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL10 (NM_000572)
    Sino Biological Human cDNA Clone for IL10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IL10
    Browse ESI BIO Cell Lines and PureStem Progenitors for IL10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IL10_HUMAN, P22301: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    plasma membrane2
    cytoskeleton1
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA10443688

    IL10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IL10 About   (see all 31)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Allograft rejection
    Allograft rejection0.86
    Asthma0.46
    Allograft Rejection0.86
    Intestinal immune network for IgA production0.41
    Autoimmune thyroid disease0.61
    THC Differentiation Pathway0.38
    2PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    MAPK Family Pathway0.60
    SOCS Pathway0.40
    JAK-STAT Pathway0.57
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IL10
        Th1 Differentiation
    IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IL10 (see all 28)
        THC Differentiation Pathway
    Endothelin-1 Signaling Pathway
    IL-10 Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    1 Cell Signaling Technology (CST) Pathway for IL10
        Lymphocyte Signaling

    2 GeneGo (Thomson Reuters) Pathways for IL10
        Apoptosis and survival APRIL and BAFF signaling
    Immune response IL-10 signaling pathway

    5 BioSystems Pathways for IL10
        Cytokines and Inflammatory Response
    SIDS Susceptibility Pathways
    Allograft Rejection
    IL4-mediated signaling events
    Regulation of nuclear SMAD2/3 signaling



    Selected Kegg Pathways  (Kegg details for IL10) (see all 20):
        Cytokine-cytokine receptor interaction
    FoxO signaling pathway
    Jak-STAT signaling pathway
    T cell receptor signaling pathway
    Intestinal immune network for IgA production


    IL10 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL10 (see all 34): 
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Hematopoiesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IL10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for IL10 (P223012, 3 ENSP000004122374) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL10RAQ136512, 3, ENSP000002277524MINT-24888 I2D: score=6 STRING: ENSP00000227752
    IL10RBQ083343, ENSP000002902004I2D: score=2 STRING: ENSP00000290200
    A2MP010233, ENSP000003239294I2D: score=2 STRING: ENSP00000323929
    TLR4O002063, ENSP000003630894I2D: score=1 STRING: ENSP00000363089
    IFNAR2P485513I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 50):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001818negative regulation of cytokine production ----
    GO:0002237response to molecule of bacterial origin IDA17449476
    GO:0002740negative regulation of cytokine secretion involved in immune response IDA10443688
    GO:0002875negative regulation of chronic inflammatory response to antigenic stimulus IEA--
    GO:0002904positive regulation of B cell apoptotic process IDA9184696

    IL10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IL10

    Selected Novoseek inferred chemical compound relationships for IL10 gene (see all 132)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    il 10 94.6 1439 16331571 (7), 19771178 (7), 12394188 (7), 16954457 (7) (see all 99)
    rantes 79.9 287 10048682 (5), 16911685 (5), 17460443 (5), 17015691 (4) (see all 99)
    il-12 72.4 47 11479428 (3), 11403227 (3), 17324967 (2), 18508030 (2) (see all 36)
    endotoxin 67.9 214 7561121 (8), 15637455 (6), 11176172 (5), 12566670 (4) (see all 99)
    pge2 63.7 390 9002960 (6), 15219461 (6), 8018602 (6), 12496396 (5) (see all 99)
    ammonium trichloro(dioxoethylene-o,o')tellurate 63.1 3 20100863 (1), 14996748 (1)
    ionomycin 61.6 54 16265694 (2), 9518518 (2), 18023089 (2), 10674971 (1) (see all 48)
    allergens 58.3 40 16238790 (2), 11564436 (2), 12731045 (2), 9590218 (1) (see all 30)
    neopterin 58.1 80 8844339 (4), 15284959 (3), 9339750 (3), 11051235 (3) (see all 46)
    ccl3 57.7 24 20041183 (2), 16501053 (1), 18239321 (1), 14578205 (1) (see all 18)



    IL10 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IL10 gene: 
    NM_000572.2  

    Unigene Cluster for IL10:

    Interleukin 10
    Hs.193717  [show with all ESTs]
    Unigene Representative Sequence: BC022315
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000423557(uc001hen.1) ENST00000471071 ENST00000367099
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IL10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IL10 (see all 37):
    hsa-miR-361-5p hsa-let-7d hsa-miR-513a-5p hsa-miR-374a hsa-miR-29b-1* hsa-miR-3916 hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidIL10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IL10
    Predesigned siRNA for gene silencing in human, mouse, rat IL10
    Clone
    Products:
         
    OriGene clones in human, mouse for IL10 (see all 5)
    OriGene ORF clones in mouse, rat for IL10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IL10 (NM_000572)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IL10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IL10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IL10
    OriGene qSTAR qPCR primer pairs in human, mouse for IL10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL10
      QuantiTect SYBR Green Assays in human, mouse, rat IL10
      QuantiFast Probe-based Assays in human, mouse, rat IL10

    Additional mRNA sequence: 

    AF043333.1 AY029171.1 BC022315.1 BC104252.1 BC104253.1 CR541993.1 CR542028.1 EU751618.2 
    EU751619.2 M57627.1 

    2 DOTS entries:

    DT.207856  DT.40106255 

    14 AceView cDNA sequences:

    CD369014 M57627 AY029171 CR541993 NM_000572 AF043333 CA308268 CR542028 
    T29794 AA382010 CD641785 BC022315 AW951607 BG538741 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    IL10 expression in normal human tissues (normalized intensities)      IL10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IL10 Expression
    About this image


    IL10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Bone marrow-derived hematopoietic stem cells
             cd31+ cells   
     
     Motor Neurons (Nervous System)
             Motor neuron progenitor cells
     
     Neurons
             Motor neuron progenitor cells
     
     NULL (Uncategorized)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Bone (Muscoskeletal System)
             Bone marrow-derived mesenchymal stem cells and monocytes (Ixmyelocel-T)
    IL10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IL10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.193717

    UniProtKB/Swiss-Prot: IL10_HUMAN, P22301
    Tissue specificity: Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell
    types

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IL10 (see all 34): 
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IL10
    OriGene qSTAR qPCR primer pairs in human, mouse for IL10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IL10
    QuantiTect SYBR Green Assays in human, mouse, rat IL10
    QuantiFast Probe-based Assays in human, mouse, rat IL10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IL10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IL10 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Il101 , 5 interleukin 101, 5 81.09(n)1
    73.03(a)1
      1 (56.89 cM)5
    161531  NM_010548.21  NP_034678.11 
     1310198455 
    chicken
    (Gallus gallus)
    Aves IL101 interleukin 10 57.89(n)
    46.2(a)
      428264  NM_001004414.2  NP_001004414.2 
    lizard
    (Anolis carolinensis)
    Reptilia IL106
    interleukin 10
    51(a)
    1 ↔ 1
    GL343228.1(1854207-1864811)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia il101 interleukin 10 59.1(n)
    50.31(a)
      100335053  NM_001171929.1  NP_001165400.1 
    zebrafish
    (Danio rerio)
    Actinopterygii il101 interleukin 10 47.78(n)
    30.64(a)
      553957  NM_001020785.2  NP_001018621.2 


    ENSEMBL Gene Tree for IL10 (if available)
    TreeFam Gene Tree for IL10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    IL10_HUMAN, P22301: A polymorphism in IL10 promoter region is associated with resistance to graft-versus-host disease
    (GVHDS) [MIM:614395]. GVHDS is a major complication of allogeneic bone marrow transplantation, in which mature
    donor T-cells that contaminate the allogeneic bone marrow recognize the tissues of the recipient as foreign,
    causing a severe inflammatory disease


    Selected SNPs for IL10 (see all 187)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs120473681,2
    --177638849(+) gaggcA/Ggaggt 1 -- ds50010--------
    rs412753521,2
    C--177638975(+) TTTCTA/GATTTT 1 -- ds50010--------
    rs1931208061,2
    --177639092(+) CTACTC/GGCTTT 1 -- ds50010--------
    rs1855499281,2
    --177639136(+) TGGAGC/GCTTCC 1 -- ds50010--------
    rs30245001,2
    C,F,A--177639157(-) CCCCCT/CACCCC 1 -- ds500114Minor allele frequency- C:0.36NS NA EU WA CSA EA 588
    rs1171066521,2
    F--177639272(+) AGAACA/TTGATG 1 -- ds50011Minor allele frequency- T:0.01EA 120
    rs30244991,2
    C,F,H--177639355(-) ATTCAA/GTTCCT 1 -- ut3113Minor allele frequency- G:0.02NS NA EU CSA WA 1068
    rs66877861,2
    C,F--177639546(+) caggtG/Acgcgc 1 -- ut31 ese34Minor allele frequency- A:0.05NA CSA 54
    rs66974971,2
    C,A--177639789(+) TCCCTC/TCGAGA 1 -- ut31 ese33Minor allele frequency- T:0.07NA WA 122
    rs1878094961,2
    --177639829(+) GCTCCC/TTGGTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for IL10 (206940947 - 206945839 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IL10: --
    Human Gene Mutation Database (HGMD): IL10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IL10
    DNA2.0 Custom Variant and Variant Library Synthesis for IL10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 124092   
    OMIM disorders: 609423  614395  180300  
    Selected diseases for IL10 (see all 491):    About MalaCards
    rheumatoid arthritis, progression of    hiv-1    intraocular lymphoma    adult pulmonary langerhans cell histiocytosis
    juvenile myasthenia gravis    punctate inner choroidopathy    graft-versus-host disease, protection against    submucous uterine fibroid
    leishmaniasis    buruli ulcer disease    panuveitis    visceral leishmaniasis
    lipoid nephrosis    clonorchiasis    stenotrophomonas maltophilia    chronic active epstein-barr virus infection
    indolent b cell lymphoma    eosinophilic fasciitis    inflammatory bowel disease 25, early onset, autosomal recessive    schistosomiasis

    18 diseases from the University of Copenhagen DISEASES database for IL10:
    Inflammatory bowel disease     Arthritis     Hypersensitivity reaction type II disease     Vascular disease
    Leishmaniasis     Connective tissue disease     Multiple sclerosis     Heart disease
    Pancreatitis     Tuberculosis     Malaria     Asthma
    Lymphoma     Liver disease     Intraocular lymphoma     Hypersensitivity reaction type I disease
    Pneumonia     Hepatitis C

    IL10 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for IL10 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 91.5 3726 9384233 (7), 11432585 (5), 9127126 (4), 12641520 (4) (see all 99)
    inflammation 82.9 558 9753488 (7), 7561121 (5), 9686613 (4), 15637455 (4) (see all 99)
    tumors 81.2 3631 7790111 (8), 10454339 (7), 10550371 (6), 8131207 (6) (see all 99)
    autoimmune diseases 73.8 91 12220553 (3), 15497451 (2), 15128840 (2), 7933621 (2) (see all 67)
    systemic inflammatory response syndrome 70.7 25 11782562 (3), 10446817 (2), 16227031 (2), 10847628 (1) (see all 20)
    rheumatoid arthritis 67.3 185 17546224 (5), 11879539 (3), 9227325 (2), 9783765 (2) (see all 99)
    multiple sclerosis 67 119 11835372 (4), 7532318 (2), 12220553 (2), 12458048 (2) (see all 83)
    sepsis 66.8 236 11421413 (5), 16435103 (4), 16162776 (4), 14642153 (4) (see all 99)
    inflammatory bowel diseases 66.5 98 11051278 (3), 9665472 (2), 11907157 (2), 10551422 (2) (see all 64)
    autoimmunity 66.5 42 8270873 (2), 20005287 (2), 16118326 (2), 9697995 (2) (see all 29)

    Genetic Association Database (GAD): IL10
    Human Genome Epidemiology (HuGE) Navigator: IL10 (1177 documents)

    Export disorders for IL10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IL10 gene, integrated from 10 sources (see all 6658):
    (articles sorted by number of sources associating them with IL10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Relation of an interleukin-10 promoter polymorphism to graft-versus- host disease and survival after hematopoietic-cell transplantation. (PubMed id 14657427)1, 2, 4, 9 Lin M.T....Hansen J.A. (N. Engl. J. Med. 2003)
    2. The combination of the interleukin-1alpha (IL-1alpha-889) genotype and the interleukin-10 (IL-10 ATA) haplotype is associated with increased interleukin-10 (IL-10) plasma levels in healthy individuals. (PubMed id 11956022)1, 4, 9 Kilpinen S....Hurme M. (Eur. Cytokine Netw. 2002)
    3. Interleukin 10 (IL-10) influences autoimmune response in primary SjAPgren's syndrome and is linked to IL-10 gene polymorphism. (PubMed id 12233881)1, 4, 9 Anaya J.M....Gallagher G. (J. Rheumatol. 2002)
    4. IL-10 promoter -1082 polymorphism is associated with elevated IL-10 levels in control subjects but does not explain elevated plasma IL-10 observed in SjAPgren's syndrome in a Hungarian cohort. (PubMed id 16305644)1, 4, 9 MA!rka M....Semsei I. (Scand. J. Immunol. 2005)
    5. Interleukin-10 and sudden infant death syndrome. (PubMed id 15325406)1, 4, 9 Moscovis S.M....Blackwell C.C. (FEMS Immunol. Med. Microbiol. 2004)
    6. Genotype and interleukin-10 responses after cardiopulmonary bypass. (PubMed id 12925485)1, 4, 9 Galley H.F....Webster N.R. (Br J Anaesth 2003)
    7. Association between a common IL10 distal promoter haplotype and IgE production in individuals with atopic dermatitis. (PubMed id 19552724)1, 4, 9 Lacy K....Bidwell J. (Int. J. Immunogenet. 2009)
    8. TNFA and IL10 gene polymorphisms are not associated with periodontitis in Brazilians. (PubMed id 19771178)1, 4, 9 Moreira P.R....Dutra W.O. (Open Dent J 2009)
    9. Association of IL-10 level and IL-10 promoter SNPs with specific antibodies in penicillin-allergic patients. (PubMed id 17225142)1, 4, 9 Qiao H.L....Jia L.J. (Eur. J. Clin. Pharmacol. 2007)
    10. [Interleukin 10 gene -627 polymorphisms in Chinese patients with early-onset coronary heart disease]. (PubMed id 16331571)1, 4, 9 Wang Y.Y....Bao Z.M. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3586 HGNC: 5962 AceView: IL10 Ensembl:ENSG00000136634 euGenes: HUgn3586
    ECgene: IL10 Kegg: 3586 H-InvDB: IL10

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IL10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IL10 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Interleukin_10
    SeattleSNPshttp://pga.gs.washington.edu/data/il10/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL10

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IL10 gene:
    Search GeneIP for patents involving IL10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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