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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IKZF5 Gene

protein-coding   GIFtS: 45
GCID: GC10M124740

IKAROS family zinc finger 5 (Pegasus)

(Previous names: zinc finger protein, subfamily 1A, 5, zinc finger protein,...)
(Previous symbol: ZNFN1A5)
 Explore 4 diseases affiliated with
IKZF5 via our new
 Human Malady Compendium 
Biological research products
for IKZF5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
IKAROS Family Zinc Finger 5 (Pegasus)1 2     Zinc Finger Protein, Subfamily 1A, 51
ZNFN1A51 2 3     PEGASUS2
Zinc Finger Protein, Subfamily 1A, 5 (Pegasus)1 2     Zinc Finger Protein Pegasus2
FLJ229731     Zinc Finger Transcription Factor Pegasus2
Pegasus1     Ikaros Family Zinc Finger Protein 53

External Ids:    HGNC: 142831   Entrez Gene: 643762   Ensembl: ENSG000000955747   OMIM: 6062385   UniProtKB: Q9H5V73   

Export aliases for IKZF5 gene to outside databases

Previous GC identifer: GC10M118370


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IKZF5:
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in
lymphocytes and are implicated in the control of lymphoid development.(supplied by OMIM, Jul 2002)

UniProtKB/Swiss-Prot: IKZF5_HUMAN, Q9H5V7
Function: DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IKZF5 gene promoter:
         GR   STAT5B   Tal-1   GR-beta   SREBP-1c   SREBP-1b   E47   GATA-1   SREBP-1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIKZF5 promoter sequence
   Search SABiosciences Chromatin IP Primers for IKZF5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IKZF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26

IKZF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IKZF5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M124740:  view genomic region     (about GC identifiers)

Start:
124,750,322 bp from pter      End:
124,768,333 bp from pter
Size:
18,012 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IKZF5_HUMAN, Q9H5V7 (See protein sequence)
Recommended Name: Zinc finger protein Pegasus  
Size: 419 amino acids; 46510 Da
Subunit: Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 AND IKZF4
Subcellular location: Nucleus (Probable)
Miscellaneous: 'Pegasus' was the winged horse in Greek mythology
Secondary accessions: B3KVH7 D3DRE7 Q9H2T0

Explore the universe of human proteins at neXtProt for IKZF5: NX_Q9H5V7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H5V7

  • IKZF5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258769.1  NP_071911.3  

    ENSEMBL proteins: 
     ENSP00000357881  

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    Uscn Proteins for IKZF5

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    IKZF5 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    IKZF5 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H5V7

    ProtoNet protein and cluster: Q9H5V7

    UniProtKB/Swiss-Prot: IKZF5_HUMAN, Q9H5V7
    Domain: The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with
    other family members
    Domain: C-terminal zinc fingers mediate homodimerization
    Similarity: Belongs to the Ikaros C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: IKZF5_HUMAN, Q9H5V7
    Function: DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor

    miRNA
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    OriGene shRNA RFP: IKZF5
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    IKZF5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for IKZF5:
     Decreased viability with pacli 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IKZF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/13 Interacting proteins for IKZF5 (Q9H5V73 ENSP000003578814) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158343, ENSP000003116954I2D: score=2 STRING: ENSP00000311695
    IKZF4Q9H2S93, ENSP000002620324I2D: score=2 STRING: ENSP00000262032
    IKZF2Q9UKS73, ENSP000004104474I2D: score=1 STRING: ENSP00000410447
    IKZF1Q134223, ENSP000003316144I2D: score=1 STRING: ENSP00000331614
    LDOC1O957513, ENSP000003595574I2D: score=2 STRING: ENSP00000359557
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    IKZF5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IKZF5
    Search CenterWatch for drugs/clinical trials and news about IKZF5 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IKZF5 gene (2 alternative transcripts): 
    NM_001271840.1  NM_022466.5  

    Unigene Cluster for IKZF5:

    IKAROS family zinc finger 5 (Pegasus)
    Hs.501289  [show with all ESTs]
    Unigene Representative Sequence: NR_073479
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368886(uc001lha.2) ENST00000496605 ENST00000469821 ENST00000479103


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    Inhib. RNA
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    Additional cDNA sequence: 

    AF230808.1 AK023288.1 AK026626.1 AK055507.1 AK122899.1 AK226143.1 BC022564.1 BX647958.1 
    CR749800.1 NR_073475.1 NR_073476.1 NR_073477.1 NR_073478.1 NR_073479.1 

    10 DOTS entries:

    DT.206978  DT.121295672  DT.100713167  DT.97824582  DT.209262  DT.92417997  DT.121295587  DT.206164 
    DT.40131748  DT.75122144 

    24/122 AceView cDNA sequences (see all 122):

    BM803093 AW151947 BX476020 AA742188 BE157286 BX647958 AL707721 BU683784 
    BX355160 AK122899 AI436720 AI500466 AA355794 BQ718240 BM703197 AA491291 
    CR602407 AA315806 AK023288 CR749800 AF230808 AA505960 AK055507 AK026626 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IKZF5 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
    SP1:        -     -                 -     -                 -     -                     
    SP2:        -     -                 -                                                   
    SP3:        -     -                 -     -                                             
    SP4:        -     -                 -     -     -                                       
    SP5:              -                 -     -                                             


    ECgene alternative splicing isoforms for IKZF5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IKZF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCTTTGATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See IKZF5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IKZF5

    SOURCE GeneReport for Unigene cluster: Hs.501289

    UniProtKB/Swiss-Prot: IKZF5_HUMAN, Q9H5V7
    Tissue specificity: Expressed in brain, heart, skeletal muscle, kidney, and liver. Expressed in the hematopoietic cell
    lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid
    and early megakaryocytic cells respectively

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IKZF5 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ikzf51 , 5 IKAROS family zinc finger 51, 5 91.25(n)1
    96.9(a)1
      7 (73.98 cM)5
    671431  NM_175115.41  NP_780324.21 
     1313886525 
    chicken
    (Gallus gallus)
    Aves IKZF51 IKAROS family zinc finger 5 (Pegasus) 82.9(n)
    93.08(a)
      430882  NM_001031595.1  NP_001026766.1 
    lizard
    (Anolis carolinensis)
    Reptilia IKZF56
    --
    91(a)
    1 ↔ 1
    3(59992167-59994595)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA982661.12   -- 75.45(n)    CA982661.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY394931.12   -- 73.97(n)    AY394931.1 


    ENSEMBL Gene Tree for IKZF5 (if available)
    TreeFam Gene Tree for IKZF5 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IKZF5 gene
    IKZF42  IKZF12  IKZF32  IKZF22  TRPS12  

    IKZF5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/183 NCBI SNPs in IKZF5 are shown (see all 183    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs774745921,2
    C,--118376623(+) NNNNTT/AAGACA 1 -- int11Minor allele frequency- A:0.00CSA 1
    rs1397246701,2
    C,--124752821(+) ACTAA-/ATGATATT 1 -- int10--------
    rs791180981,2
    F,--124752973(+) GGATAA/CGCCTT 1 -- int11Minor allele frequency- C:0.06NA 120
    rs1170114251,2
    --124752975(+) ATAAGC/TCTTGA 1 -- int11Minor allele frequency- T:0.01NA 120
    rs70799831,2
    C,F,H,--124752996(+) GACCAT/AAAATG 1 -- int1 ese36Minor allele frequency- A:0.03NS EA WA 540
    rs176541401,2
    C,F,H,--124753010(+) GAAATT/CCAAAT 1 -- int18Minor allele frequency- C:0.01NA NS EA 682
    rs94233021,2
    C,F,A,H,--124753060(+) ATGTCG/AAAAGG 1 -- int1 trp322Minor allele frequency- A:0.13NA NS EA CSA WA 2350
    rs1131188441,2
    C,--124753177(+) ATTCTATAA/-  
            
    ATATA
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs10456201,2
    --124753240(-) TTTTTG/TTTTTT 1 -- ut310--------
    rs1891867341,2
    --124753272(+) AAAACC/TAAGTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for IKZF5 (124750322 - 124768333 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for IKZF5
         1 CNV: 4714

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for IKZF5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IKZF5 for disorders           About GeneDecksing

    OMIM gene information: 606238    OMIM disorders: --

    4 diseases for IKZF5:    About MalaCards
    acute lymphoblastic leukemia    lymphoblastic leukemia    azoospermia    leukemia


    Export disorders for IKZF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IKZF5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with IKZF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PubMed id 10978333)1, 2, 3 Perdomo J.... Crossley M. (2000)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    8. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. (PubMed id 12511597)1 Moore F.L.... Reijo Pera R.A. (2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64376 HGNC: 14283 AceView: ZNFN1A5 Ensembl:ENSG00000095574 euGenes: HUgn64376
    ECgene: IKZF5 H-InvDB: IKZF5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IKZF5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IKZF5 gene:
    Search GeneIP for patents involving IKZF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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