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Aliases for IKZF5 Gene

Aliases for IKZF5 Gene

  • IKAROS Family Zinc Finger 5 2 3 5
  • Zinc Finger Protein, Subfamily 1A, 5 (Pegasus) 2 3
  • ZNFN1A5 3 4
  • Zinc Finger Transcription Factor Pegasus 3
  • IKAROS Family Zinc Finger 5 (Pegasus) 2
  • Zinc Finger Protein, Subfamily 1A, 5 2
  • Ikaros Family Zinc Finger Protein 5 4
  • Zinc Finger Protein Pegasus 3
  • PEGASUS 3

External Ids for IKZF5 Gene

Previous HGNC Symbols for IKZF5 Gene

  • ZNFN1A5

Previous GeneCards Identifiers for IKZF5 Gene

  • GC10M124740
  • GC10M118370

Summaries for IKZF5 Gene

Entrez Gene Summary for IKZF5 Gene

  • Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]

GeneCards Summary for IKZF5 Gene

IKZF5 (IKAROS Family Zinc Finger 5) is a Protein Coding gene. An important paralog of this gene is IKZF2.

UniProtKB/Swiss-Prot for IKZF5 Gene

  • DNA-binding protein that binds to the 5GNNTGTNG-3 core sequence. Transcriptional repressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IKZF5 Gene

Genomics for IKZF5 Gene

Regulatory Elements for IKZF5 Gene

Enhancers for IKZF5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F122306 1.7 FANTOM5 Ensembl ENCODE 10.8 +699.4 699447 6.5 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 FOS TBX21 KAT8 BTBD16 IKZF5 C10orf88 GC10P122346
GH10F123157 1.3 Ensembl ENCODE 10.2 -148.7 -148701 0.6 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF143 FOS HMX3 ACADSB IKZF5 BUB3 GC10P123164
GH10F122979 1.1 ENCODE 11.6 +28.3 28290 1.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 ACADSB IKZF5 BTBD16 GC10M122775 C10orf88
GH10F122284 1.1 Ensembl ENCODE 10.8 +722.2 722171 4.5 HDGF PKNOX1 ZMYM3 ZIC2 ZKSCAN1 ZNF23 GLIS2 POLR2A PATZ1 ZNF26 BTBD16 IKZF5 HTRA1 GC10P122346
GH10F122953 1.1 ENCODE 10.7 +54.7 54696 1.6 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 C10orf88 IKZF5 PSTK FAM24A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IKZF5 on UCSC Golden Path with GeneCards custom track

Promoters for IKZF5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000223044 150 3001 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for IKZF5 Gene

Chromosome:
10
Start:
122,990,806 bp from pter
End:
123,008,850 bp from pter
Size:
18,045 bases
Orientation:
Minus strand

Genomic View for IKZF5 Gene

Genes around IKZF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IKZF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IKZF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IKZF5 Gene

Proteins for IKZF5 Gene

  • Protein details for IKZF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5V7-IKZF5_HUMAN
    Recommended name:
    Zinc finger protein Pegasus
    Protein Accession:
    Q9H5V7
    Secondary Accessions:
    • B3KVH7
    • D3DRE7
    • Q9H2T0

    Protein attributes for IKZF5 Gene

    Size:
    419 amino acids
    Molecular mass:
    46510 Da
    Quaternary structure:
    • Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 AND IKZF4.
    Miscellaneous:
    • Pegasus was the winged horse in Greek mythology.

neXtProt entry for IKZF5 Gene

Post-translational modifications for IKZF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IKZF5 Gene

Domains & Families for IKZF5 Gene

Gene Families for IKZF5 Gene

Protein Domains for IKZF5 Gene

Suggested Antigen Peptide Sequences for IKZF5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H5V7

UniProtKB/Swiss-Prot:

IKZF5_HUMAN :
  • The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.
  • Belongs to the Ikaros C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
Domain:
  • The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.
  • C-terminal zinc fingers mediate homodimerization.
Family:
  • Belongs to the Ikaros C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with IKZF5: view

Function for IKZF5 Gene

Molecular function for IKZF5 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that binds to the 5GNNTGTNG-3 core sequence. Transcriptional repressor.

Gene Ontology (GO) - Molecular Function for IKZF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with IKZF5: view
genes like me logo Genes that share phenotypes with IKZF5: view

Animal Models for IKZF5 Gene

MGI Knock Outs for IKZF5:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IKZF5 Gene

Localization for IKZF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IKZF5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IKZF5 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for IKZF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with IKZF5: view

Pathways & Interactions for IKZF5 Gene

SuperPathways for IKZF5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IKZF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with IKZF5: view

No data available for Pathways by source and SIGNOR curated interactions for IKZF5 Gene

Transcripts for IKZF5 Gene

Unigene Clusters for IKZF5 Gene

IKAROS family zinc finger 5 (Pegasus):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IKZF5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
SP1: - - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6:
SP7: - -
SP8:

Relevant External Links for IKZF5 Gene

GeneLoc Exon Structure for
IKZF5
ECgene alternative splicing isoforms for
IKZF5

Expression for IKZF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IKZF5 Gene

Protein differential expression in normal tissues from HIPED for IKZF5 Gene

This gene is overexpressed in Adrenal (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IKZF5 Gene



Protein tissue co-expression partners for IKZF5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IKZF5 Gene:

IKZF5

SOURCE GeneReport for Unigene cluster for IKZF5 Gene:

Hs.501289

mRNA Expression by UniProt/SwissProt for IKZF5 Gene:

Q9H5V7-IKZF5_HUMAN
Tissue specificity: Expressed in brain, heart, skeletal muscle, kidney, and liver. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.
genes like me logo Genes that share expression patterns with IKZF5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for IKZF5 Gene

Orthologs for IKZF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IKZF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IKZF5 35 34
  • 99.68 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IKZF5 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IKZF5 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IKZF5 34 35
  • 93.79 (n)
rat
(Rattus norvegicus)
Mammalia Ikzf5 34
  • 92.28 (n)
cow
(Bos Taurus)
Mammalia IKZF5 35 34
  • 91.81 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ikzf5 34 16 35
  • 91.25 (n)
chicken
(Gallus gallus)
Aves IKZF5 34 35
  • 82.9 (n)
lizard
(Anolis carolinensis)
Reptilia IKZF5 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ikzf5 34
  • 75.66 (n)
zebrafish
(Danio rerio)
Actinopterygii ikzf5 34 35
  • 67.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.781 35
  • 18 (a)
OneToOne
Species where no ortholog for IKZF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IKZF5 Gene

ENSEMBL:
Gene Tree for IKZF5 (if available)
TreeFam:
Gene Tree for IKZF5 (if available)

Paralogs for IKZF5 Gene

Paralogs for IKZF5 Gene

genes like me logo Genes that share paralogs with IKZF5: view

Variants for IKZF5 Gene

Sequence variations from dbSNP and Humsavar for IKZF5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10159750 -- 122,997,606(+) AGGCC(A/G)TACCC intron-variant, downstream-variant-500B
rs1045620 -- 122,993,724(-) TTTTT(G/T)TTTTT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10510118 -- 123,006,295(+) AGGAT(G/T)TATTT intron-variant, nc-transcript-variant, utr-variant-5-prime
rs10510119 -- 123,007,283(+) TCATT(A/G)CATTA intron-variant, upstream-variant-2KB
rs1060572 -- 123,009,293(+) GAAGC(G/T)GCTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IKZF5 Gene

Variant ID Type Subtype PubMed ID
nsv7586 CNV insertion 18451855
nsv832010 CNV gain 17160897

Variation tolerance for IKZF5 Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IKZF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IKZF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IKZF5 Gene

Disorders for IKZF5 Gene

Relevant External Links for IKZF5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IKZF5

No disorders were found for IKZF5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IKZF5 Gene

Publications for IKZF5 Gene

  1. Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PMID: 10978333) Perdomo J. … Crossley M. (J. Biol. Chem. 2000) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. (PMID: 25755297) Xiao Z. … Vertegaal A.C. (Mol. Cell. Proteomics 2015) 4 64
  5. SUMO-2 orchestrates chromatin modifiers in response to DNA damage. (PMID: 25772364) Hendriks I.A. … Vertegaal A.C. (Cell Rep. 2015) 4 64

Products for IKZF5 Gene

Sources for IKZF5 Gene

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