Aliases for IKZF5 Gene
Aliases for IKZF5 Gene
External Ids for IKZF5 Gene
- HGNC: 14283
- Entrez Gene: 64376
- Ensembl: ENSG00000095574
- OMIM: 606238
- UniProtKB: Q9H5V7
Previous HGNC Symbols for IKZF5 Gene
- ZNFN1A5
Previous GeneCards Identifiers for IKZF5 Gene
- GC10M124740
- GC10M118370
Summaries for IKZF5 Gene
-
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
GeneCards Summary for IKZF5 Gene
IKZF5 (IKAROS Family Zinc Finger 5) is a Protein Coding gene. An important paralog of this gene is IKZF4.
UniProtKB/Swiss-Prot for IKZF5 Gene
-
DNA-binding protein that binds to the 5GNNTGTNG-3 core sequence. Transcriptional repressor.
No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IKZF5 Gene
Genomics for IKZF5 Gene
Regulatory Elements for IKZF5 Gene
Enhancers for IKZF5 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around IKZF5 on UCSC Golden Path with GeneCards custom track
Promoters for IKZF5 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around IKZF5 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for IKZF5 Gene
- Chromosome:
- 10
- Start:
- 122,990,806 bp from pter
- End:
- 123,008,850 bp from pter
- Size:
- 18,045 bases
- Orientation:
- Minus strand
Genomic View for IKZF5 Gene
Genes around IKZF5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q26.13 by Ensembl
- 10q26 by Entrez Gene
- 10q26 by HGNC
IKZF5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IKZF5 Gene
Proteins for IKZF5 Gene
-
Protein details for IKZF5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H5V7-IKZF5_HUMAN
- Recommended name:
- Zinc finger protein Pegasus
- Protein Accession:
- Q9H5V7
- B3KVH7
- D3DRE7
- Q9H2T0
Protein attributes for IKZF5 Gene
- Size:
- 419 amino acids
- Molecular mass:
- 46510 Da
- Quaternary structure:
-
- Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 AND IKZF4.
- Miscellaneous:
-
- Pegasus was the winged horse in Greek mythology.
Protein Expression for IKZF5 Gene
Post-translational modifications for IKZF5 Gene
Other Protein References for IKZF5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for IKZF5
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- antibodies-online Antibodies for IKZF5: See all 10
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-
Santa Cruz Biotechnology (SCBT) Antibodies for IKZF5
Protein Products
-
OriGene Purified Proteins for IKZF5
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- antibodies-online Proteins for IKZF5: See all 8
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- Search GeneTex for Proteins for IKZF5
Assay Products
- antibodies-online Kits for IKZF5: See all 9
No data available for DME Specific Peptides for IKZF5 Gene
Domains & Families for IKZF5 Gene
Gene Families for IKZF5 Gene
Protein Domains for IKZF5 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for IKZF5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H5V7UniProtKB/Swiss-Prot:
IKZF5_HUMAN :- The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.
- Belongs to the Ikaros C2H2-type zinc-finger protein family.
- Contains 5 C2H2-type zinc fingers.
- Domain:
-
- The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.
- C-terminal zinc fingers mediate homodimerization.
- Family:
-
- Belongs to the Ikaros C2H2-type zinc-finger protein family.
- Similarity:
-
- Contains 5 C2H2-type zinc fingers.
Function for IKZF5 Gene
Molecular function for IKZF5 Gene
- UniProtKB/Swiss-Prot Function:
- DNA-binding protein that binds to the 5GNNTGTNG-3 core sequence. Transcriptional repressor.
Phenotypes for IKZF5 Gene
- GenomeRNAi human phenotypes for IKZF5:
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for IKZF5 gene
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CRISPR Products
-
OriGene CRISPR knockouts for IKZF5
-
Santa Cruz Biotechnology (SCBT) CRISPR for IKZF5
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miRNA for IKZF5 Gene
- miRTarBase miRNAs that target IKZF5
-
- hsa-mir-935 (MIRT036641)
- hsa-mir-20a-5p (MIRT050501)
- hsa-mir-580-3p (MIRT445963)
- hsa-mir-526b-5p (MIRT445964)
- hsa-mir-4533 (MIRT445965)
- hsa-mir-6124 (MIRT445966)
- hsa-mir-539-5p (MIRT445967)
- hsa-mir-6876-5p (MIRT445968)
- hsa-mir-1252-5p (MIRT445969)
- hsa-mir-4476 (MIRT445970)
- hsa-mir-651-3p (MIRT445971)
- hsa-mir-335-3p (MIRT536672)
- hsa-mir-1305 (MIRT536673)
- hsa-mir-607 (MIRT536674)
- hsa-mir-8078 (MIRT536675)
- hsa-mir-1287-3p (MIRT536676)
- hsa-mir-520h (MIRT536677)
- hsa-mir-3973 (MIRT536678)
- hsa-mir-520g-3p (MIRT536679)
- hsa-mir-559 (MIRT536680)
- hsa-mir-548y (MIRT536681)
- hsa-mir-548w (MIRT536682)
- hsa-mir-548o-5p (MIRT536683)
- hsa-mir-548j-5p (MIRT536684)
- hsa-mir-548i (MIRT536685)
- hsa-mir-548h-5p (MIRT536686)
- hsa-mir-548d-5p (MIRT536687)
- hsa-mir-548c-5p (MIRT536688)
- hsa-mir-548bb-5p (MIRT536689)
- hsa-mir-548b-5p (MIRT536690)
- hsa-mir-548ay-5p (MIRT536691)
- hsa-mir-548au-5p (MIRT536692)
- hsa-mir-548as-5p (MIRT536693)
- hsa-mir-548ar-5p (MIRT536694)
- hsa-mir-548aq-5p (MIRT536695)
- hsa-mir-548ap-5p (MIRT536696)
- hsa-mir-548am-5p (MIRT536697)
- hsa-mir-548ak (MIRT536698)
- hsa-mir-548ae-5p (MIRT536699)
- hsa-mir-548ad-5p (MIRT536700)
- hsa-mir-548ab (MIRT536701)
- hsa-mir-548a-5p (MIRT536702)
- hsa-mir-3692-3p (MIRT657183)
- hsa-mir-550b-3p (MIRT657184)
- hsa-mir-1228-3p (MIRT657185)
- hsa-mir-501-5p (MIRT657186)
- hsa-mir-500b-5p (MIRT657187)
- hsa-mir-362-5p (MIRT657188)
- hsa-mir-6074 (MIRT657189)
miRNA Products
- Search ViGene Biosciences for IKZF5
Clone Products
- OriGene clones in human for IKZF5
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for IKZF5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for IKZF5 gene
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IKZF5 Gene
Localization for IKZF5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IKZF5 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
No data available for Gene Ontology (GO) - Cellular Components for IKZF5 Gene
Pathways & Interactions for IKZF5 Gene
More details on SuperPathways for IKZF5
No Data Available
Interacting Proteins for IKZF5 Gene
No data available for Pathways by source and SIGNOR curated interactions for IKZF5 Gene
Transcripts for IKZF5 Gene
mRNA/cDNA for IKZF5 Gene
- (2) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (122) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for IKZF5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for IKZF5
-
Santa Cruz Biotechnology (SCBT) CRISPR for IKZF5
- GenScript: Design CRISPR guide RNA sequences for IKZF5
miRNA Products
- Search ViGene Biosciences for IKZF5
Clone Products
- OriGene clones in human for IKZF5
- OriGene ORF clones in human,mouse,rat for IKZF5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||
| SP8: |
Expression for IKZF5 Gene
This gene is overexpressed in Adrenal (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IKZF5 Gene
SOURCE GeneReport for Unigene cluster for IKZF5 Gene Hs.501289
mRNA Expression by UniProt/SwissProt for IKZF5 Gene
Q9H5V7-IKZF5_HUMAN
Tissue specificity:
Expressed in brain, heart, skeletal muscle, kidney, and liver. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.
- Elite partner
Primer Products
-
OriGene qPCR primer pairs and template standards for IKZF5
-
OriGene qPCR primer pairs for IKZF5
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for IKZF5 Gene
Orthologs for IKZF5 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | IKZF5 35 |
|
||
| IKZF5 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | IKZF5 35 |
|
||
| IKZF5 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Ikzf5 35 |
|
||
| Ikzf5 16 |
|
||||
| Ikzf5 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | IKZF5 35 |
|
||
| IKZF5 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Ikzf5 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | IKZF5 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | IKZF5 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | IKZF5 35 |
|
||
| IKZF5 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | IKZF5 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ikzf5 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ikzf5 35 |
|
||
| ikzf5 36 |
|
OneToOne | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.781 36 |
|
OneToOne |
- Species with no ortholog for IKZF5:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for IKZF5 Gene
Variants for IKZF5 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs11595364 | -- | 123,004,912(+) | AAAGT(A/G)AAGTA | intron-variant | |
| rs11595933 | -- | 123,005,837(+) | gaact(A/G)tgaga | intron-variant | |
| rs7899321 | -- | 123,005,146(+) | AAAAA(A/T)TTCTG | intron-variant | |
| rs7899939 | -- | 123,006,195(+) | GGTAT(A/G)AGAGA | intron-variant | |
| rs35066195 | -- | 123,001,162(+) | ACCAC(-/A)GCCCA | intron-variant |
Residual Variation Intolerance Score:
23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.88;
18.42% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IKZF5 Gene
Disorders for IKZF5 Gene
Relevant External Links for IKZF5
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- IKZF5
No disorders were found for IKZF5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IKZF5 Gene
Publications for IKZF5 Gene
- Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PMID: 10978333) Perdomo J. … Crossley M. (J. Biol. Chem. 2000) 2 3 4 67
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
- Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
- Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
Products for IKZF5 Gene
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- OriGene qPCR primer pairs for IKZF5
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- antibodies-online Antibodies for IKZF5: See all 10
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- antibodies-online Proteins for IKZF5: See all 8
- Search antibodies-online for peptides
- GeneTex IKZF5 antibody for IKZF5
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- ViGene Biosciences adenoviral particle packaged cDNA for IKZF5 gene
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Sources for IKZF5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
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- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
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- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
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- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
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- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon