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IKZF5 Gene

protein-coding   GIFtS: 46
GCID: GC10M124740

IKAROS Family Zinc Finger 5 (Pegasus)

(Previous names: zinc finger protein, subfamily 1A, 5, zinc finger protein,...)
(Previous symbol: ZNFN1A5)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
IKAROS Family Zinc Finger 5 (Pegasus)1 2     PEGASUS2
ZNFN1A51 2 3     Zinc Finger Protein Pegasus2
Zinc Finger Protein, Subfamily 1A, 5 (Pegasus)1 2     Zinc Finger Transcription Factor Pegasus2
Zinc Finger Protein, Subfamily 1A, 51     Ikaros Family Zinc Finger Protein 53

External Ids:    HGNC: 142831   Entrez Gene: 643762   Ensembl: ENSG000000955747   OMIM: 6062385   UniProtKB: Q9H5V73   
ORGUL members:         

Export aliases for IKZF5 gene to outside databases

Previous GC identifer: GC10M118370


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IKZF5 Gene:
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed
in lymphocytes and are implicated in the control of lymphoid development.(supplied by OMIM, Jul 2002)

GeneCards Summary for IKZF5 Gene:
IKZF5 (IKAROS family zinc finger 5 (Pegasus)) is a protein-coding gene. An important paralog of this gene is IKZF4.

UniProtKB/Swiss-Prot: IKZF5_HUMAN, Q9H5V7
Function: DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IKZF5 gene promoter:
         GR   STAT5B   Tal-1   GR-beta   SREBP-1c   SREBP-1b   E47   GATA-1   SREBP-1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIKZF5 promoter sequence
   Search Chromatin IP Primers for IKZF5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IKZF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26

IKZF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IKZF5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M124740:  view genomic region     (about GC identifiers)

Start:
124,750,322 bp from pter      End:
124,768,333 bp from pter
Size:
18,012 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IKZF5_HUMAN, Q9H5V7 (See protein sequence)
Recommended Name: Zinc finger protein Pegasus  
Size: 419 amino acids; 46510 Da
Subunit: Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 AND IKZF4
Miscellaneous: 'Pegasus' was the winged horse in Greek mythology
Secondary accessions: B3KVH7 D3DRE7 Q9H2T0

Explore the universe of human proteins at neXtProt for IKZF5: NX_Q9H5V7

Explore proteomics data for IKZF5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IKZF5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001258769.1  
    ENSEMBL proteins: 
     ENSP00000357881  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IKZF: IKAROS zinc fingers
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H5V7

    ProtoNet protein and cluster: Q9H5V7

    UniProtKB/Swiss-Prot: IKZF5_HUMAN, Q9H5V7
    Domain: The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations
    with other family members
    Domain: C-terminal zinc fingers mediate homodimerization
    Similarity: Belongs to the Ikaros C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers


    Find genes that share domains with IKZF5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IKZF5_HUMAN, Q9H5V7
    Function: DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with IKZF5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IKZF5:
     Decreased viability with pacli 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IKZF5_HUMAN, Q9H5V7: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with IKZF5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IKZF5
    Interactions:

        Search GeneGlobe Interaction Network for IKZF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for IKZF5 (Q9H5V73 ENSP000003578814) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158343, ENSP000003116954I2D: score=2 STRING: ENSP00000311695
    IKZF4Q9H2S93, ENSP000002620324I2D: score=2 STRING: ENSP00000262032
    IKZF2Q9UKS73, ENSP000004104474I2D: score=1 STRING: ENSP00000410447
    IKZF1Q134223, ENSP000003316144I2D: score=1 STRING: ENSP00000331614
    LDOC1O957513, ENSP000003595574I2D: score=2 STRING: ENSP00000359557
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with IKZF5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IKZF5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IKZF5 gene: 
    NM_001271840.1  

    Unigene Cluster for IKZF5:

    IKAROS family zinc finger 5 (Pegasus)
    Hs.501289  [show with all ESTs]
    Unigene Representative Sequence: NR_073479
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368886(uc001lha.2) ENST00000496605 ENST00000469821 ENST00000479103

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      QuantiTect SYBR Green Assays in human, mouse, rat IKZF5
      QuantiFast Probe-based Assays in human, mouse, rat IKZF5

    Additional mRNA sequence: 

    AF230808.1 AK023288.1 AK026626.1 AK055507.1 AK122899.1 AK226143.1 BC022564.1 BX647958.1 
    CR749800.1 NR_073475.1 NR_073476.1 NR_073477.1 NR_073478.1 NR_073479.1 

    10 DOTS entries:

    DT.206978  DT.121295672  DT.100713167  DT.97824582  DT.209262  DT.92417997  DT.121295587  DT.206164 
    DT.40131748  DT.75122144 

    Selected AceView cDNA sequences (see all 122):

    AK023288 AI500466 AA505960 T36216 AF230808 AW151947 AA742188 AA491291 
    AI436720 AA355794 BX647958 AA315806 BM703197 AK055507 AL707721 BE157286 
    CR602407 CR749800 AI560579 BX476020 BU683784 BM803093 CR591039 BX355160 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IKZF5 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
    SP1:        -     -                 -     -                 -     -                     
    SP2:        -     -                 -                                                   
    SP3:        -     -                 -     -                                             
    SP4:        -     -                 -     -     -                                       
    SP5:              -                 -     -                                             


    ECgene alternative splicing isoforms for IKZF5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IKZF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTTGATG
    IKZF5 Expression
    About this image

    IKZF5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IKZF5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.501289

    UniProtKB/Swiss-Prot: IKZF5_HUMAN, Q9H5V7
    Tissue specificity: Expressed in brain, heart, skeletal muscle, kidney, and liver. Expressed in the hematopoietic
    cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics
    of myeloid and early megakaryocytic cells respectively

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IKZF5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ikzf51 , 5 IKAROS family zinc finger 51, 5 91.25(n)1
    96.9(a)1
      7 (73.98 cM)5
    671431  NM_175115.41  NP_780324.21 
     1313886525 
    chicken
    (Gallus gallus)
    Aves IKZF51 IKAROS family zinc finger 5 (Pegasus) 82.9(n)
    93.08(a)
      430882  NM_001031595.1  NP_001026766.1 
    lizard
    (Anolis carolinensis)
    Reptilia IKZF56
    IKAROS family zinc finger 5 (Pegasus)
    91(a)
    1 ↔ 1
    3(59989615-59995165)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA982661.12   -- 75.45(n)    CA982661.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY394931.12   -- 73.97(n)    AY394931.1 


    ENSEMBL Gene Tree for IKZF5 (if available)
    TreeFam Gene Tree for IKZF5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IKZF5 gene
    IKZF42  IKZF12  IKZF32  IKZF22  

    Find genes that share paralogs with IKZF5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IKZF5 (see all 257)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1818956981,2
    --124750421(+) TTTCCA/GGAATC 6 -- ut31 nc-transcript-variant0--------
    rs1487256451,2
    --124750653(+) TTTGTA/GGTATT 6 -- ut31 nc-transcript-variant0--------
    rs133530581,2
    C,F,H--124750722(+) CTGGAA/GACACC 6 -- ut31 nc-transcript-variantese316Minor allele frequency- G:0.06NS EA NA CSA 1942
    rs1865840801,2
    --124750939(+) GAACAC/TTGCCT 6 -- ut31 nc-transcript-variant0--------
    rs94232411,2
    C,F,H--124751028(+) TAAAAT/CGAGTG 6 -- ut31 nc-transcript-variantese35Minor allele frequency- C:0.05NS EA 540
    rs1907252441,2
    --124751120(+) ATTTTA/TAAAAA 6 -- ut31 nc-transcript-variant0--------
    rs1133133621,2
    C,F--124751459(+) AAGAAT/CAAAAA 6 -- ut31 nc-transcript-variant2Minor allele frequency- C:0.05NA WA 120
    rs1809731951,2
    --124751530(+) AATACC/TAAAGC 6 -- ut31 nc-transcript-variant0--------
    rs133288261,2
    C,F,H--124751623(+) ATTTTA/CAAGTA 6 -- ut31 nc-transcript-variant14Minor allele frequency- C:0.04NS EA NA WA 1890
    rs1862430731,2
    --124751729(+) AAGAAC/TTCATT 6 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for IKZF5 (124750322 - 124768333 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IKZF5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7586CNV Insertion18451855
    nsv832010CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606238    OMIM disorders: --


    Find genes that share disorders with IKZF5           About GenesLikeMe


    Export disorders for IKZF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IKZF5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with IKZF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PubMed id 10978333)1, 2, 3 Perdomo J.... Crossley M. (J. Biol. Chem. 2000)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    6. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    7. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. (PubMed id 12511597)1 Moore F.L.... Reijo Pera R.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64376 HGNC: 14283 AceView: ZNFN1A5 Ensembl:ENSG00000095574 euGenes: HUgn64376
    ECgene: IKZF5 H-InvDB: IKZF5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IKZF5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IKZF5 gene:
    Search GeneIP for patents involving IKZF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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