Aliases for IKZF5 Gene
Aliases for IKZF5 Gene
External Ids for IKZF5 Gene
- HGNC: 14283
- Entrez Gene: 64376
- Ensembl: ENSG00000095574
- OMIM: 606238
- UniProtKB: Q9H5V7
Previous HGNC Symbols for IKZF5 Gene
- ZNFN1A5
Previous GeneCards Identifiers for IKZF5 Gene
- GC10M124740
- GC10M118370
Summaries for IKZF5 Gene
-
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
GeneCards Summary for IKZF5 Gene
IKZF5 (IKAROS Family Zinc Finger 5) is a Protein Coding gene. An important paralog of this gene is IKZF2.
UniProtKB/Swiss-Prot for IKZF5 Gene
-
DNA-binding protein that binds to the 5GNNTGTNG-3 core sequence. Transcriptional repressor.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IKZF5 Gene
Genomics for IKZF5 Gene
GeneHancer (GH) Regulatory Elements for IKZF5 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH10I123007 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 550.8 | +0.3 | 268 | 2.8 | HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 | ACADSB IKZF5 BTBD16 GC10M122775 | |
GH10I123008 | Promoter | 0.5 | EPDnew | 550.8 | +1.8 | 1806 | 0.1 | ACADSB IKZF5 GC10M122775 | ||
GH10I122953 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 19.4 | +54.8 | 54783 | 1.7 | HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 | C10orf88 PSTK BUB3 IKZF5 FAM24A GC10M122775 | |
GH10I122979 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 11.6 | +28.3 | 28290 | 1.7 | HDGF FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 ZNF207 | PSTK ACADSB BUB3 IKZF5 BTBD16 GC10M122775 C10orf88 | |
GH10I122306 | Enhancer | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 10.8 | +699.4 | 699446 | 6.5 | FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 IRF4 YY1 FOS REST | BTBD16 IKZF5 BUB3 NSMCE4A GC10P122346 |
Regulatory Element Products
Genomic Locations for IKZF5 Gene
- chr10:122,990,806-123,008,850
- (GRCh38/hg38)
- Size:
- 18,045 bases
- Orientation:
- Minus strand
- chr10:124,750,322-124,768,333
- (GRCh37/hg19)
Genomic View for IKZF5 Gene
- Cytogenetic band:
-
- 10q26.13 by Ensembl
- 10q26.13 by Entrez Gene
- 10q26.13 by HGNC


RefSeq DNA sequence for IKZF5 Gene
Proteins for IKZF5 Gene
-
Protein details for IKZF5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H5V7-IKZF5_HUMAN
- Recommended name:
- Zinc finger protein Pegasus
- Protein Accession:
- Q9H5V7
- B3KVH7
- D3DRE7
- Q9H2T0
Protein attributes for IKZF5 Gene
- Size:
- 419 amino acids
- Molecular mass:
- 46510 Da
- Quaternary structure:
-
- Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 AND IKZF4.
- Miscellaneous:
-
- Pegasus was the winged horse in Greek mythology.
Protein Expression for IKZF5 Gene
Post-translational modifications for IKZF5 Gene
Other Protein References for IKZF5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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Assay Products
No data available for DME Specific Peptides for IKZF5 Gene
Domains & Families for IKZF5 Gene
Gene Families for IKZF5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for IKZF5 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for IKZF5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H5V7UniProtKB/Swiss-Prot:
IKZF5_HUMAN :- The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.
- Belongs to the Ikaros C2H2-type zinc-finger protein family.
- Domain:
-
- The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.
- C-terminal zinc fingers mediate homodimerization.
- Family:
-
- Belongs to the Ikaros C2H2-type zinc-finger protein family.
Function for IKZF5 Gene
Molecular function for IKZF5 Gene
- UniProtKB/Swiss-Prot Function:
- DNA-binding protein that binds to the 5GNNTGTNG-3 core sequence. Transcriptional repressor.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 10978333 |
GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IDA | 10978333 |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0008270 | zinc ion binding | IMP | 15491138 |
Phenotypes for IKZF5 Gene
- MGI mutant phenotypes for IKZF5:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for IKZF5:
Animal Models for IKZF5 Gene
- MGI Knock Outs for IKZF5:
-
- Ikzf5 tm1(KOMP)Wtsi
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miRNA for IKZF5 Gene
- miRTarBase miRNAs that target IKZF5
-
- hsa-mir-935 (MIRT036641)
- hsa-mir-20a-5p (MIRT050501)
- hsa-mir-580-3p (MIRT445963)
- hsa-mir-526b-5p (MIRT445964)
- hsa-mir-4533 (MIRT445965)
- hsa-mir-6124 (MIRT445966)
- hsa-mir-539-5p (MIRT445967)
- hsa-mir-6876-5p (MIRT445968)
- hsa-mir-1252-5p (MIRT445969)
- hsa-mir-4476 (MIRT445970)
- hsa-mir-651-3p (MIRT445971)
- hsa-mir-335-3p (MIRT536672)
- hsa-mir-1305 (MIRT536673)
- hsa-mir-607 (MIRT536674)
- hsa-mir-8078 (MIRT536675)
- hsa-mir-1287-3p (MIRT536676)
- hsa-mir-520h (MIRT536677)
- hsa-mir-3973 (MIRT536678)
- hsa-mir-520g-3p (MIRT536679)
- hsa-mir-559 (MIRT536680)
- hsa-mir-548y (MIRT536681)
- hsa-mir-548w (MIRT536682)
- hsa-mir-548o-5p (MIRT536683)
- hsa-mir-548j-5p (MIRT536684)
- hsa-mir-548i (MIRT536685)
- hsa-mir-548h-5p (MIRT536686)
- hsa-mir-548d-5p (MIRT536687)
- hsa-mir-548c-5p (MIRT536688)
- hsa-mir-548bb-5p (MIRT536689)
- hsa-mir-548b-5p (MIRT536690)
- hsa-mir-548ay-5p (MIRT536691)
- hsa-mir-548au-5p (MIRT536692)
- hsa-mir-548as-5p (MIRT536693)
- hsa-mir-548ar-5p (MIRT536694)
- hsa-mir-548aq-5p (MIRT536695)
- hsa-mir-548ap-5p (MIRT536696)
- hsa-mir-548am-5p (MIRT536697)
- hsa-mir-548ak (MIRT536698)
- hsa-mir-548ae-5p (MIRT536699)
- hsa-mir-548ad-5p (MIRT536700)
- hsa-mir-548ab (MIRT536701)
- hsa-mir-548a-5p (MIRT536702)
- hsa-mir-3692-3p (MIRT657183)
- hsa-mir-550b-3p (MIRT657184)
- hsa-mir-1228-3p (MIRT657185)
- hsa-mir-501-5p (MIRT657186)
- hsa-mir-500b-5p (MIRT657187)
- hsa-mir-362-5p (MIRT657188)
- hsa-mir-6074 (MIRT657189)
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IKZF5
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Horizon Cell Lines for IKZF5
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IKZF5 Gene
Localization for IKZF5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IKZF5 Gene
- Nucleus.
- Cytosol (3)
- Nucleoplasm (3)
- Plasma membrane (3)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0043234 | protein complex | IMP | 15491138 |
Pathways & Interactions for IKZF5 Gene
Interacting Proteins for IKZF5 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 10978333 |
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0051291 | protein heterooligomerization | IMP | 15491138 |
No data available for Pathways by source and SIGNOR curated interactions for IKZF5 Gene
Transcripts for IKZF5 Gene
mRNA/cDNA for IKZF5 Gene
- (8) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (122) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for IKZF5 Gene
CRISPR Products
-
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-
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IKZF5
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- Applied Biological Materials Clones for IKZF5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b |
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SP1: | - | - | - | - | - | - | |||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||
SP8: |
Expression for IKZF5 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IKZF5 Gene
NURSA nuclear receptor signaling pathways regulating expression of IKZF5 Gene:
IKZF5SOURCE GeneReport for Unigene cluster for IKZF5 Gene:
Hs.501289mRNA Expression by UniProt/SwissProt for IKZF5 Gene:
Q9H5V7-IKZF5_HUMANEvidence on tissue expression from TISSUES for IKZF5 Gene
- Nervous system(3)
Primer Products
-
OriGene qPCR primer pairs for IKZF5
-
OriGene qPCR primer pairs and template standards for IKZF5
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IKZF5 Gene
Orthologs for IKZF5 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | IKZF5 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | IKZF5 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | IKZF5 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | IKZF5 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Ikzf5 33 |
|
||
cow (Bos Taurus) |
Mammalia | IKZF5 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Ikzf5 33 16 34 |
|
||
chicken (Gallus gallus) |
Aves | IKZF5 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | IKZF5 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | ikzf5 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | ikzf5 33 34 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.781 34 |
|
OneToOne |
- Species where no ortholog for IKZF5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for IKZF5 Gene
Variants for IKZF5 Gene
SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs12263012 | benign, Deficiency of 2-methylbutyryl-CoA dehydrogenase | 123,009,067(-) | G/A | upstream_transcript_variant | |
rs141443308 | likely-benign, Deficiency of 2-methylbutyryl-CoA dehydrogenase | 123,008,941(-) | G/T | upstream_transcript_variant | |
rs148327034 | uncertain-significance, Deficiency of 2-methylbutyryl-CoA dehydrogenase | 123,008,933(-) | T/C | upstream_transcript_variant | |
rs150850221 | likely-benign, Deficiency of 2-methylbutyryl-CoA dehydrogenase | 123,008,943(-) | G/T | upstream_transcript_variant | |
rs190149746 | likely-benign, Deficiency of 2-methylbutyryl-CoA dehydrogenase | 123,008,923(-) | G/A/C | upstream_transcript_variant |
Additional Variant Information for IKZF5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- IKZF5
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IKZF5 Gene
Disorders for IKZF5 Gene
Additional Disease Information for IKZF5
No disorders were found for IKZF5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IKZF5 Gene
Publications for IKZF5 Gene
- Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PMID: 10978333) Perdomo J … Crossley M (The Journal of biological chemistry 2000) 2 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
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- Compare Top IKZF5 Proteins
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- GeneTex IKZF5 antibody for IKZF5
- Search GeneTex for Proteins for IKZF5
- ViGene Biosciences adenoviral particle packaged cDNA for IKZF5 gene
- ViGene Biosciences lentiviral particle packaged cDNA for IKZF5 gene
- Search ViGene Biosciences for IKZF5
- Santa Cruz Biotechnology (SCBT) Antibodies for IKZF5
- Search Santa Cruz Biotechnology (SCBT) for IKZF5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IKZF5
- Horizon Cell Lines for IKZF5
- genomics-online: cdna clones - Search results for available IKZF5 gene related products
- orf clones - Search results for available IKZF5 gene related products
- genomics-online: gRNA clones - Search results for available IKZF5 gene related products
- genomics-online: primer clones - Search results for available IKZF5 gene related products
- genomics-online: shRNA clones - Search results for available IKZF5 gene related products
Sources for IKZF5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew