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Aliases for IKZF5 Gene

Aliases for IKZF5 Gene

  • IKAROS Family Zinc Finger 5 (Pegasus) 2 3
  • Zinc Finger Protein, Subfamily 1A, 5 (Pegasus) 2 3
  • ZNFN1A5 3 4
  • Zinc Finger Transcription Factor Pegasus 3
  • Zinc Finger Protein, Subfamily 1A, 5 2
  • Ikaros Family Zinc Finger Protein 5 4
  • Zinc Finger Protein Pegasus 3
  • PEGASUS 3

External Ids for IKZF5 Gene

Previous Symbols for IKZF5 Gene

  • ZNFN1A5

Summaries for IKZF5 Gene

Entrez Gene Summary for IKZF5 Gene

  • Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]

GeneCards Summary for IKZF5 Gene

IKZF5 (IKAROS Family Zinc Finger 5 (Pegasus)) is a Protein Coding gene. An important paralog of this gene is IKZF2.

UniProtKB/Swiss-Prot for IKZF5 Gene

  • DNA-binding protein that binds to the 5GNNTGTNG-3 core sequence. Transcriptional repressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IKZF5 Gene

Genomics for IKZF5 Gene

Genomic Location for IKZF5 Gene

Start:
122,990,806 bp from pter
End:
123,008,850 bp from pter
Size:
18,045 bases
Orientation:
Minus strand

Genomic View for IKZF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IKZF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IKZF5 Gene

Regulatory Elements for IKZF5 Gene

Proteins for IKZF5 Gene

  • Protein details for IKZF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5V7-IKZF5_HUMAN
    Recommended name:
    Zinc finger protein Pegasus
    Protein Accession:
    Q9H5V7
    Secondary Accessions:
    • B3KVH7
    • D3DRE7
    • Q9H2T0

    Protein attributes for IKZF5 Gene

    Size:
    419 amino acids
    Molecular mass:
    46510 Da
    Quaternary structure:
    • Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 AND IKZF4.
    Miscellaneous:
    • Pegasus was the winged horse in Greek mythology

neXtProt entry for IKZF5 Gene

Proteomics data for IKZF5 Gene at MOPED

Post-translational modifications for IKZF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IKZF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IKZF5 Gene

Domains for IKZF5 Gene

Gene Families for IKZF5 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • IKZF :IKAROS zinc fingers

Protein Domains for IKZF5 Gene

UniProtKB/Swiss-Prot:

IKZF5_HUMAN
Domain:
  • The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members:
    • Q9H5V7
  • C-terminal zinc fingers mediate homodimerization:
    • Q9H5V7
Family:
  • Belongs to the Ikaros C2H2-type zinc-finger protein family.:
    • Q9H5V7
Similarity:
  • Contains 5 C2H2-type zinc fingers.:
    • Q9H5V7
genes like me logo Genes that share domains with IKZF5: view

Function for IKZF5 Gene

Molecular function for IKZF5 Gene

UniProtKB/Swiss-Prot Function: DNA-binding protein that binds to the 5GNNTGTNG-3 core sequence. Transcriptional repressor.

Gene Ontology (GO) - Molecular Function for IKZF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with IKZF5: view

Phenotypes for IKZF5 Gene

GenomeRNAi human phenotypes for IKZF5:
genes like me logo Genes that share phenotypes with IKZF5: view

miRNA for IKZF5 Gene

miRTarBase miRNAs that target IKZF5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IKZF5 Gene

Localization for IKZF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IKZF5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IKZF5 Gene COMPARTMENTS Subcellular localization image for IKZF5 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for IKZF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with IKZF5: view

Pathways for IKZF5 Gene

SuperPathways for IKZF5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IKZF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with IKZF5: view

No data available for Pathways by source for IKZF5 Gene

Transcripts for IKZF5 Gene

Unigene Clusters for IKZF5 Gene

IKAROS family zinc finger 5 (Pegasus):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IKZF5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
SP1: - - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6:
SP7: - -
SP8:

Relevant External Links for IKZF5 Gene

GeneLoc Exon Structure for
IKZF5
ECgene alternative splicing isoforms for
IKZF5

Expression for IKZF5 Gene

mRNA expression in normal human tissues for IKZF5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IKZF5 Gene

SOURCE GeneReport for Unigene cluster for IKZF5 Gene Hs.501289

mRNA Expression by UniProt/SwissProt for IKZF5 Gene

Q9H5V7-IKZF5_HUMAN
Tissue specificity: Expressed in brain, heart, skeletal muscle, kidney, and liver. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.
genes like me logo Genes that share expressions with IKZF5: view

Orthologs for IKZF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IKZF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IKZF5 36
  • 99.68 (n)
  • 99.76 (a)
IKZF5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IKZF5 36
  • 91.81 (n)
  • 97.37 (a)
IKZF5 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IKZF5 36
  • 93.79 (n)
  • 98.57 (a)
IKZF5 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ikzf5 36
  • 91.25 (n)
  • 96.9 (a)
Ikzf5 16
Ikzf5 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IKZF5 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IKZF5 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ikzf5 36
  • 92.28 (n)
  • 98.57 (a)
chicken
(Gallus gallus)
Aves IKZF5 36
  • 82.9 (n)
  • 93.08 (a)
IKZF5 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IKZF5 37
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ikzf5 36
  • 75.66 (n)
  • 87.11 (a)
zebrafish
(Danio rerio)
Actinopterygii ikzf5 36
  • 67.49 (n)
  • 70.79 (a)
ikzf5 37
  • 68 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.781 37
  • 18 (a)
OneToOne
Species with no ortholog for IKZF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IKZF5 Gene

ENSEMBL:
Gene Tree for IKZF5 (if available)
TreeFam:
Gene Tree for IKZF5 (if available)

Paralogs for IKZF5 Gene

Paralogs for IKZF5 Gene

genes like me logo Genes that share paralogs with IKZF5: view

Variants for IKZF5 Gene

Sequence variations from dbSNP and Humsavar for IKZF5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1045620 -- 122,993,724(-) TTTTT(G/T)TTTTT utr-variant-3-prime, nc-transcript-variant
rs4980172 -- 122,992,612(+) ATTCA(C/T)TTCCA utr-variant-3-prime, nc-transcript-variant
rs4980242 -- 122,997,984(+) TAAAT(A/T)CCAGT intron-variant
rs7079983 -- 122,993,480(+) GACCA(A/T)AAATG utr-variant-3-prime, nc-transcript-variant
rs7899321 -- 123,005,146(+) AAAAA(A/T)TTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IKZF5 Gene

Variant ID Type Subtype PubMed ID
nsv832010 CNV Gain 17160897
nsv7586 CNV Insertion 18451855

Relevant External Links for IKZF5 Gene

HapMap Linkage Disequilibrium report
IKZF5

Disorders for IKZF5 Gene

No disorders were found for IKZF5 Gene.

No data available for UniProtKB/Swiss-Prot for IKZF5 Gene

Publications for IKZF5 Gene

  1. Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PMID: 10978333) Perdomo J. … Crossley M. (J. Biol. Chem. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for IKZF5 Gene

Sources for IKZF5 Gene

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