Set Analyses:
GeneALaCart
GeneDecks
VarElect
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 


IKZF5 Gene

protein-coding   GIFtS: 46
GCID: GC10M124740

IKAROS Family Zinc Finger 5 (Pegasus)

(Previous names: zinc finger protein, subfamily 1A, 5, zinc finger protein,...)
(Previous symbol: ZNFN1A5)
  See related diseases
at
MalaCards
 

Aliases
for IKZF5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
IKAROS Family Zinc Finger 5 (Pegasus)1 2     PEGASUS2
ZNFN1A51 2 3     Zinc Finger Protein Pegasus2
Zinc Finger Protein, Subfamily 1A, 5 (Pegasus)1 2     Zinc Finger Transcription Factor Pegasus2
Zinc Finger Protein, Subfamily 1A, 51     Ikaros Family Zinc Finger Protein 53

External Ids:    HGNC: 142831   Entrez Gene: 643762   Ensembl: ENSG000000955747   OMIM: 6062385   UniProtKB: Q9H5V73   
ORGUL members:         

Export aliases for IKZF5 gene to outside databases

Previous GC identifer: GC10M118370


Summaries
for IKZF5 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus
Entrez Gene summary for IKZF5 Gene:
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed
in lymphocytes and are implicated in the control of lymphoid development.(supplied by OMIM, Jul 2002)

GeneCards Summary for IKZF5 Gene:
IKZF5 (IKAROS family zinc finger 5 (Pegasus)) is a protein-coding gene. Diseases associated with IKZF5 include azoospermia, and lymphoblastic leukemia. An important paralog of this gene is IKZF4.

UniProtKB/Swiss-Prot: IKZF5_HUMAN, Q9H5V7
Function: DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor




Genomic Views
for IKZF5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IKZF5 gene promoter:
         GR   STAT5B   Tal-1   GR-beta   SREBP-1c   SREBP-1b   E47   GATA-1   SREBP-1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IKZF5 promoter sequence
   Search Chromatin IP Primers for IKZF5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IKZF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26

IKZF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IKZF5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M124740:  view genomic region     (about GC identifiers)

Start:
 124,750,322 bp from pter      End:
 124,768,333 bp from pter
Size:
 18,012 bases      Orientation:
 minus strand

Proteins
for IKZF5 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus
UniProtKB/Swiss-Prot: IKZF5_HUMAN, Q9H5V7 (See protein sequence)
Recommended Name: Zinc finger protein Pegasus  
Size: 419 amino acids; 46510 Da
Subunit: Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 AND IKZF4
Miscellaneous: 'Pegasus' was the winged horse in Greek mythology
Secondary accessions: B3KVH7 D3DRE7 Q9H2T0

Explore the universe of human proteins at neXtProt for IKZF5: NX_Q9H5V7

Explore proteomics data for IKZF5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

    • See IKZF5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001258769.1  
    ENSEMBL proteins: 
     ENSP00000357881  

    IKZF5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IKZF5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IKZF5
    GenScript Custom Purified and Recombinant Proteins Services for IKZF5
    Novus Biologicals IKZF5 Protein
    Novus Biologicals IKZF5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IKZF5

    IKZF5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IKZF5
    Novus Biologicals IKZF5 Antibodies
    Abcam antibodies for IKZF5
    Cloud-Clone Corp. Antibodies for IKZF5
    Search ThermoFisher Antibodies for IKZF5
    LSBio Antibodies in human, mouse, rat for IKZF5

    IKZF5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IKZF5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IKZF5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IKZF5
    Cloud-Clone Corp. CLIAs for IKZF5

    Domains /
    Families
    for IKZF5 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    IKZF: IKAROS zinc fingers
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H5V7

    ProtoNet protein and cluster: Q9H5V7

    UniProtKB/Swiss-Prot: IKZF5_HUMAN, Q9H5V7
    Domain: The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations
    with other family members
    Domain: C-terminal zinc fingers mediate homodimerization
    Similarity: Belongs to the Ikaros C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers


    IKZF5 for domains           About GeneDecksing


    Function
    for IKZF5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IKZF5_HUMAN, Q9H5V7
    Function: DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    IKZF5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IKZF5:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IKZF5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IKZF5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IKZF5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IKZF5

    miRNA
    Products:            		miRTarBase miRNAs that target IKZF5:
    hsa-mir-935 (MIRT036641), hsa-mir-20a-5p (MIRT050501)

    Block miRNA regulation of human, mouse, rat IKZF5 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IKZF5
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for IKZF5
    Predesigned siRNA for gene silencing in human, mouse, rat IKZF5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IKZF5

    Clone
    Products:             		 OriGene clones in human, mouse for IKZF5 (see all 7)
    OriGene ORF clones in mouse, rat for IKZF5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IKZF5 (NM_022466)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IKZF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKZF5

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IKZF5
    Browse ESI BIO Cell Lines and PureStem Progenitors for IKZF5 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKZF5


    Localization
    for IKZF5 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus
    Subcellular locations from UniProtKB/Swiss-Prot
    IKZF5_HUMAN, Q9H5V7: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    IKZF5 for ontologies           About GeneDecksing


    Pathways & Interactions
    for IKZF5 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IKZF5
    Interactions:

        Search GeneGlobe Interaction Network for IKZF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for IKZF5 (Q9H5V73 ENSP000003578814) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158343, ENSP000003116954I2D: score=2 STRING: ENSP00000311695
    IKZF4Q9H2S93, ENSP000002620324I2D: score=2 STRING: ENSP00000262032
    IKZF2Q9UKS73, ENSP000004104474I2D: score=1 STRING: ENSP00000410447
    IKZF1Q134223, ENSP000003316144I2D: score=1 STRING: ENSP00000331614
    LDOC1O957513, ENSP000003595574I2D: score=2 STRING: ENSP00000359557
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    IKZF5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IKZF5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IKZF5



    Transcripts
    for IKZF5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus
    REFSEQ mRNAs for IKZF5 gene: 
    NM_001271840.1  

    Unigene Cluster for IKZF5:

    IKAROS family zinc finger 5 (Pegasus)
    Hs.501289  [show with all ESTs]
    Unigene Representative Sequence: NR_073479
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368886(uc001lha.2) ENST00000496605 ENST00000469821 ENST00000479103

    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat IKZF5 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IKZF5
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for IKZF5
    Predesigned siRNA for gene silencing in human, mouse, rat IKZF5
    Clone
    Products:             		 OriGene clones in human, mouse for IKZF5 (see all 7)
    OriGene ORF clones in mouse, rat for IKZF5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IKZF5 (NM_022466)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IKZF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKZF5
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for IKZF5
    OriGene qSTAR qPCR primer pairs in human, mouse for IKZF5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IKZF5
      QuantiTect SYBR Green Assays in human, mouse, rat IKZF5
      QuantiFast Probe-based Assays in human, mouse, rat IKZF5

    Additional mRNA sequence: 

    AF230808.1 AK023288.1 AK026626.1 AK055507.1 AK122899.1 AK226143.1 BC022564.1 BX647958.1 
    CR749800.1 NR_073475.1 NR_073476.1 NR_073477.1 NR_073478.1 NR_073479.1 

    10 DOTS entries:

    DT.206978  DT.121295672  DT.100713167  DT.97824582  DT.209262  DT.92417997  DT.121295587  DT.206164 
    DT.40131748  DT.75122144 

    Selected AceView cDNA sequences (see all 122):

    AK023288 AI500466 AA505960 T36216 AF230808 AW151947 AA742188 AA491291 
    AI436720 AA355794 BX647958 AA315806 BM703197 AK055507 AL707721 BE157286 
    CR602407 CR749800 AI560579 BX476020 BU683784 BM803093 CR591039 BX355160 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IKZF5 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
    SP1:        -     -                 -     -                 -     -                     
    SP2:        -     -                 -                                                   
    SP3:        -     -                 -     -                                             
    SP4:        -     -                 -     -     -                                       
    SP5:              -                 -     -                                             


    ECgene alternative splicing isoforms for IKZF5

    Expression
    for IKZF5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IKZF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTTGATG
    IKZF5 Expression
    About this image

    IKZF5 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    IKZF5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.501289

    UniProtKB/Swiss-Prot: IKZF5_HUMAN, Q9H5V7
    Tissue specificity: Expressed in brain, heart, skeletal muscle, kidney, and liver. Expressed in the hematopoietic
    cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics
    of myeloid and early megakaryocytic cells respectively

        Custom PCR Arrays for IKZF5
    Primer
    Products:    		OriGene qPCR primer pairs and template standards for IKZF5
    OriGene qSTAR qPCR primer pairs in human, mouse for IKZF5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IKZF5
    QuantiTect SYBR Green Assays in human, mouse, rat IKZF5
    QuantiFast Probe-based Assays in human, mouse, rat IKZF5
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKZF5

    Orthologs
    for IKZF5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus
    This gene was present in the common ancestor of chordates.

    Orthologs for IKZF5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ikzf51 , 5 IKAROS family zinc finger 51, 5 91.25(n)1
    96.9(a)1    		   7 (73.98 cM)5
    671431  NM_175115.41  NP_780324.21 
     1313886525 
    chicken
    (Gallus gallus)    		 Aves IKZF51 IKAROS family zinc finger 5 (Pegasus) 82.9(n)
    93.08(a)    		   430882  NM_001031595.1  NP_001026766.1 
    lizard
    (Anolis carolinensis)    		 Reptilia IKZF56
    		 IKAROS family zinc finger 5 (Pegasus)
    		 91(a)
    		 1 ↔ 1
    		 3(59989615-59995165)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CA982661.12   -- 75.45(n)    CA982661.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AY394931.12   -- 73.97(n)    AY394931.1 


    ENSEMBL Gene Tree for IKZF5 (if available)
    TreeFam Gene Tree for IKZF5 (if available)

    Paralogs
    for IKZF5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for IKZF5 gene
    IKZF42  IKZF12  IKZF32  IKZF22  

    IKZF5 for paralogs           About GeneDecksing



    Genomic Variants
    for IKZF5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Selected SNPs for IKZF5 (see all 257)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1818956981,2
    		--124750421(+) TTTCCA/GGAATC 6 -- ut31 nc-transcript-variant0--------
    rs1487256451,2
    		--124750653(+) TTTGTA/GGTATT 6 -- ut31 nc-transcript-variant0--------
    rs133530581,2
    		C,F,H--124750722(+) CTGGAA/GACACC 6 -- ut31 nc-transcript-variantese316Minor allele frequency- G:0.06NS EA NA CSA 1942
    rs1865840801,2
    		--124750939(+) GAACAC/TTGCCT 6 -- ut31 nc-transcript-variant0--------
    rs94232411,2
    		C,F,H--124751028(+) TAAAAT/CGAGTG 6 -- ut31 nc-transcript-variantese35Minor allele frequency- C:0.05NS EA 540
    rs1907252441,2
    		--124751120(+) ATTTTA/TAAAAA 6 -- ut31 nc-transcript-variant0--------
    rs1133133621,2
    		C,F--124751459(+) AAGAAT/CAAAAA 6 -- ut31 nc-transcript-variant2Minor allele frequency- C:0.05NA WA 120
    rs1809731951,2
    		--124751530(+) AATACC/TAAAGC 6 -- ut31 nc-transcript-variant0--------
    rs133288261,2
    		C,F,H--124751623(+) ATTTTA/CAAGTA 6 -- ut31 nc-transcript-variant14Minor allele frequency- C:0.04NS EA NA WA 1890
    rs1862430731,2
    		--124751729(+) AAGAAC/TTCATT 6 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for IKZF5 (124750322 - 124768333 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IKZF5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7586CNV Insertion18451855
    nsv832010CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IKZF5
    DNA2.0 Custom Variant and Variant Library Synthesis for IKZF5

    Disorders / Diseases
    for IKZF5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606238    OMIM disorders: --

    3 diseases for IKZF5:    
    About MalaCards
    azoospermia    lymphoblastic leukemia    leukemia


    IKZF5 for disorders           About GeneDecksing


    Export disorders for IKZF5 gene to outside databases

    Publications
    for IKZF5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus
    PubMed articles for IKZF5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with IKZF5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PubMed id 10978333)1, 2, 3 Perdomo J.... Crossley M. (J. Biol. Chem. 2000)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    6. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    7. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. (PubMed id 12511597)1 Moore F.L.... Reijo Pera R.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    External Searches for IKZF5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IKZF5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 64376 HGNC: 14283 AceView: ZNFN1A5 Ensembl:ENSG00000095574 euGenes: HUgn64376
    ECgene: IKZF5 H-InvDB: IKZF5

    Other Databases showing IKZF5 gene

    (According to HUGE)
    About This Section

    TryGeneCards Plus    		   --

    Specialized Databases showing IKZF5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IKZF5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IKZF5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for IKZF5 gene:
    Search GeneIP for patents involving IKZF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for IKZF5 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for IKZF5  
     OriGene qPCR primer pairs and template standards for IKZF5   OriGene Protein Over-expression Lysate for IKZF5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for IKZF5  
     OriGene qSTAR qPCR primer pairs in human, mouse for IKZF5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for IKZF5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IKZF5   OriGene Custom Protein Services for IKZF5  

         		 
     Block miRNA regulation of human, mouse, rat IKZF5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IKZF5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IKZF5 Predesigned siRNA for gene silencing in human, mouse, rat IKZF5
     QuantiFast Probe-based Assays in human, mouse, rat IKZF5 QuantiTect SYBR Green Assays in human, mouse, rat IKZF5
     Custom PCR Arrays for IKZF5 Search Chromatin IP Primers for IKZF5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IKZF5  Search GeneGlobe Interaction Network for IKZF5
     Regulatory tfbs in IKZF5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for IKZF5 GenScript cDNA clones with any tag delivered in your preferred vector for IKZF5
     GenScript Custom Assay Services for IKZF5 GenScript Custom overexpressing Cell Line Services for IKZF5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for IKZF5
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IKZF5 antibodies
     IKZF5 proteins
     IKZF5 lysates
     Antibodies for IKZF5
     See all of Abcam's Antibodies, Kits and Proteins for IKZF5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for IKZF5
     Antibodies for IKZF5
     ELISAs for IKZF5
     CLIAs for IKZF5



     Browse ESI BIO Cell Lines and PureStem Progenitors for IKZF5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKZF5
     Browse SwitchGear 3'UTR luciferase reporter plasmids for IKZF5
     SwitchGear Promoter luciferase reporter plasmids for IKZF5
     Search ThermoFisher Antibodies for IKZF5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKZF5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IKZF5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IKZF5
     LSBio Antibodies in human, mouse, rat for IKZF5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      IKZF5 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4