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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IKZF5 Gene

protein-coding GIFtS: 44
GCID: GC10M124740

IKAROS Family Zinc Finger 5 (Pegasus)

(Previous names: zinc finger protein, subfamily 1A, 5, zinc finger protein,...)
(Previous symbol: ZNFN1A5)

4 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
IKAROS Family Zinc Finger 5 (Pegasus)¹ ²		PEGASUS²
ZNFN1A5¹ ² ³		Zinc Finger Protein Pegasus²
Zinc Finger Protein, Subfamily 1A, 5 (Pegasus)¹ ²		Zinc Finger Transcription Factor Pegasus²
Zinc Finger Protein, Subfamily 1A, 5¹		Ikaros Family Zinc Finger Protein 5³

External Ids:	HGNC: 14283¹	Entrez Gene: 64376²	Ensembl: ENSG00000095574⁷	OMIM: 606238⁵	UniProtKB: Q9H5V7³

Export aliases for IKZF5 gene to outside databases

Previous GC identifer: GC10M118370

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IKZF5 Gene:

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed

in lymphocytes and are implicated in the control of lymphoid development.(supplied by OMIM, Jul 2002)

GeneCards Summary for IKZF5 Gene:

IKZF5 (IKAROS family zinc finger 5 (Pegasus)) is a protein-coding gene. Diseases associated with IKZF5 include azoospermia, and acute lymphoblastic leukemia. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is IKZF4.

UniProtKB/Swiss-Prot: IKZF5_HUMAN, Q9H5V7

Function: DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.2 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IKZF5 gene promoter:
GR STAT5B Tal-1 GR-beta SREBP-1c SREBP-1b E47 GATA-1 SREBP-1a GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IKZF5 promoter sequence

Search SABiosciences Chromatin IP Primers for IKZF5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IKZF5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26 Ensembl cytogenetic band: 10q26.13 HGNC cytogenetic band: 10q26

IKZF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IKZF5 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M124740: view genomic region (about GC identifiers)

Start:	124,750,322 bp from pter	End:	124,768,333 bp from pter
Size:	18,012 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IKZF5_HUMAN, Q9H5V7 (See protein sequence)

Recommended Name: Zinc finger protein Pegasus

Size: 419 amino acids; 46510 Da

Subunit: Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 AND IKZF4

Subcellular location: Nucleus (Probable)

Miscellaneous: 'Pegasus' was the winged horse in Greek mythology

Secondary accessions: B3KVH7 D3DRE7 Q9H2T0

Explore the universe of human proteins at neXtProt for IKZF5: NX_Q9H5V7

Explore proteomics data for IKZF5 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9H5V7

IKZF5 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_001258769.1

ENSEMBL proteins:

ENSP00000357881

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	Cloud-Clone Corp. Proteins for IKZF5

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

IKZF5 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

IKZF: IKAROS zinc fingers

ZNF: Zinc fingers, C2H2-type

3 InterPro protein domains:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q9H5V7

ProtoNet protein and cluster: Q9H5V7

UniProtKB/Swiss-Prot: IKZF5_HUMAN, Q9H5V7

Domain: The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations

with other family members

Domain: C-terminal zinc fingers mediate homodimerization

Similarity: Belongs to the Ikaros C2H2-type zinc-finger protein family

Similarity: Contains 5 C2H2-type zinc fingers

IKZF5 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: IKZF5_HUMAN, Q9H5V7

Function: DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	--	--
GO:0046872	metal ion binding	IEA	--

IKZF5 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for IKZF5:

Decreased viability with pacli

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IKZF5

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/13 Interacting proteins for IKZF5 (Q9H5V7³ ENSP00000357881⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCDC85B	Q15834³, ENSP00000311695⁴	I2D: score=2 STRING: ENSP00000311695
IKZF4	Q9H2S9³, ENSP00000262032⁴	I2D: score=2 STRING: ENSP00000262032
IKZF2	Q9UKS7³, ENSP00000410447⁴	I2D: score=1 STRING: ENSP00000410447
IKZF1	Q13422³, ENSP00000331614⁴	I2D: score=1 STRING: ENSP00000331614
LDOC1	O95751³, ENSP00000359557⁴	I2D: score=2 STRING: ENSP00000359557

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

IKZF5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IKZF5

Search CenterWatch for drugs/clinical trials and news about IKZF5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IKZF5 gene:

NM_001271840.1

Unigene Cluster for IKZF5:

IKAROS family zinc finger 5 (Pegasus)

Hs.501289 [show with all ESTs]

Unigene Representative Sequence: NR_073479

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000368886(uc001lha.2) ENST00000496605 ENST00000469821 ENST00000479103

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Additional mRNA sequence:

AF230808.1 AK023288.1 AK026626.1 AK055507.1 AK122899.1 AK226143.1 BC022564.1 BX647958.1

CR749800.1 NR_073475.1 NR_073476.1 NR_073477.1 NR_073478.1 NR_073479.1

10 DOTS entries:

DT.206978 DT.121295672 DT.100713167 DT.97824582 DT.209262 DT.92417997 DT.121295587 DT.206164

DT.40131748 DT.75122144

24/122 AceView cDNA sequences (see all 122):

AK023288 BE157286 CR602407 CR749800 AK122899 AL707721 AA315806 BM803093

AK026626 AI436720 AI560579 BM703197 BQ718240 AA742188 BX647958 AK055507

T36216 BU683784 BX476020 AI500466 AF230808 AA355794 AA491291 AA505960

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IKZF5 (see all 8) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b
SP1:			-		-						-		-						-		-
SP2:			-		-						-
SP3:			-		-						-		-
SP4:			-		-						-		-		-
SP5:					-						-		-

ECgene alternative splicing isoforms for IKZF5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IKZF5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGCTTTGATG

About this image

See IKZF5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IKZF5

SOURCE GeneReport for Unigene cluster: Hs.501289

UniProtKB/Swiss-Prot: IKZF5_HUMAN, Q9H5V7

Tissue specificity: Expressed in brain, heart, skeletal muscle, kidney, and liver. Expressed in the hematopoietic

cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics

of myeloid and early megakaryocytic cells respectively

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IKZF5 gene from 5/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ikzf5^{1 , 5}	IKAROS family zinc finger 5^{1, 5}	91.25(n)¹ 96.9(a)¹		7 (73.98 cM)⁵ 67143¹ NM_175115.4¹ NP_780324.2¹ 131388652⁵
chicken (Gallus gallus)	Aves	IKZF5¹	IKAROS family zinc finger 5 (Pegasus)	82.9(n) 93.08(a)		430882 NM_001031595.1 NP_001026766.1
lizard (Anolis carolinensis)	Reptilia	IKZF5⁶	Uncharacterized protein	91(a)	1 ↔ 1	3(59989615-59995165)
African clawed frog (Xenopus laevis)	Amphibia	CA982661.1²	--	75.45(n)		CA982661.1
zebrafish (Danio rerio)	Actinopterygii	AY394931.1²	--	73.97(n)		AY394931.1

ENSEMBL Gene Tree for IKZF5 (if available)
TreeFam Gene Tree for IKZF5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IKZF5 gene

IKZF4² IKZF1² IKZF3² IKZF2²

IKZF5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181895698^1,2		--	124750421(+)	`TTTCCA/GGAATC`	6	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs148725645^1,2		--	124750653(+)	`TTTGTA/GGTATT`	6	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs13353058^1,2	C,F,H	--	124750722(+)	`CTGGAA/GACACC`	6	--	ut3¹ nc-transcript-variantese³		16		NS EA NA CSA	1942
rs186584080^1,2		--	124750939(+)	`GAACAC/TTGCCT`	6	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs9423241^1,2	C,F,H	--	124751028(+)	`TAAAAT/CGAGTG`	6	--	ut3¹ nc-transcript-variantese³		5		NS EA	540
rs190725244^1,2		--	124751120(+)	`ATTTTA/TAAAAA`	6	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs113313362^1,2	C,F	--	124751459(+)	`AAGAAT/CAAAAA`	6	--	ut3¹ nc-transcript-variant		2		NA WA	120
rs180973195^1,2		--	124751530(+)	`AATACC/TAAAGC`	6	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs13328826^1,2	C,F,H	--	124751623(+)	`ATTTTA/CAAGTA`	6	--	ut3¹ nc-transcript-variant		14		NS EA NA WA	1890
rs186243073^1,2		--	124751729(+)	`AAGAAC/TTCATT`	6	--	ut3¹ nc-transcript-variant		0	--	--	--	--

HapMap Linkage Disequilibrium report for IKZF5 (124750322 - 124768333 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for IKZF5: About this table

Variant ID	Type	Subtype	PubMed ID
nsv7586	CNV	Insertion	18451855
nsv832010	CNV	Gain	17160897

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 606238 OMIM disorders: --

4 diseases for IKZF5: About MalaCards

azoospermia acute lymphoblastic leukemia lymphoblastic leukemia leukemia

IKZF5 for disorders About GeneDecksing

Export disorders for IKZF5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IKZF5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IKZF5)

Utopia: connect your pdf to the dynamic
world of online information

Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PubMed id 10978333)^{1, 2, 3} Perdomo J.... Crossley M. (2000)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. (PubMed id 12511597)¹ Moore F.L.... Reijo Pera R.A. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 64376	HGNC: 14283	AceView: ZNFN1A5	Ensembl:ENSG00000095574	euGenes: HUgn64376
ECgene: IKZF5	H-InvDB: IKZF5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IKZF5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IKZF5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IKZF5 gene:
Search GeneIP for patents involving IKZF5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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IKZF5 Gene

IKAROS Family Zinc Finger 5 (Pegasus)

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IKZF5 Gene

IKAROS Family Zinc Finger 5 (Pegasus)

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