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Aliases for IKZF4 Gene

Aliases for IKZF4 Gene

  • IKAROS Family Zinc Finger 4 2 3 5
  • Zinc Finger Protein, Subfamily 1A, 4 (Eos) 2 3
  • Ikaros Family Zinc Finger Protein 4 3 4
  • ZNFN1A4 3 4
  • Zinc Finger Transcription Factor Eos 3
  • IKAROS Family Zinc Finger 4 (Eos) 2
  • Zinc Finger Protein Eos 3
  • KIAA1782 4
  • EOS 3

External Ids for IKZF4 Gene

Previous HGNC Symbols for IKZF4 Gene

  • ZNFN1A4

Previous GeneCards Identifiers for IKZF4 Gene

  • GC12P054705
  • GC12P056414
  • GC12P053453

Summaries for IKZF4 Gene

Entrez Gene Summary for IKZF4 Gene

  • Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]

GeneCards Summary for IKZF4 Gene

IKZF4 (IKAROS Family Zinc Finger 4) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and protein homodimerization activity. An important paralog of this gene is IKZF2.

UniProtKB/Swiss-Prot for IKZF4 Gene

  • DNA-binding protein that binds to the 5GGGAATRCC-3 Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity).

Gene Wiki entry for IKZF4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IKZF4 Gene

Genomics for IKZF4 Gene

Regulatory Elements for IKZF4 Gene

Enhancers for IKZF4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G056028 1.3 Ensembl ENCODE dbSUPER 12.4 +21.8 21767 1.7 CTCF PKNOX1 SAP130 ARID4B DNMT3B ZBTB40 RAD21 ZNF121 CTBP1 GATA3 RAB5B PMEL IKZF4 SUOX CDK2 PA2G4 ORMDL2 SARNP LOC105369781 LOC105369780
GH12G056045 1.4 Ensembl ENCODE dbSUPER 10.9 +38.9 38855 2.8 HDGF ATF1 ARID4B ZNF2 GTF3C2 ZNF143 KLF13 ZNF263 REST SMARCA4 PA2G4 RPL41 ZC3H10 BAZ2A PMEL RN7SL809P GDF11 ERBB3 CDK2 IKZF4
GH12G055982 1.1 Ensembl ENCODE 12 -24.9 -24872 0.9 PKNOX1 TCF12 ZNF121 CBX5 RELB BCLAF1 IKZF2 SMARCA5 ZBTB2 TBX21 IKZF4 GDF11 CD63 PMEL ERBB3 PA2G4 RPL41 ZC3H10 SARNP ORMDL2
GH12G055983 0.9 ENCODE 12 -24.1 -24056 0.2 HDGF HDAC1 RB1 ARNT FEZF1 RAD21 TCF12 GATA2 FOS ZNF680 IKZF4 ERBB3 LOC100131294 GC12P055992
GH12G056071 0.6 ENCODE 10.6 +64.1 64095 0.1 SOX13 BHLHE40 CEBPG ZNF384 RARA TEAD3 ZNF121 CEBPA PA2G4 RPS26 RPL41 ZC3H10 IKZF4 SUOX SMARCC2 ERBB3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IKZF4 on UCSC Golden Path with GeneCards custom track

Promoters for IKZF4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052467 -46 1600 HDGF PKNOX1 ARNT AGO1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9

Genomic Location for IKZF4 Gene

Chromosome:
12
Start:
56,007,647 bp from pter
End:
56,038,435 bp from pter
Size:
30,789 bases
Orientation:
Plus strand

Genomic View for IKZF4 Gene

Genes around IKZF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IKZF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IKZF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IKZF4 Gene

Proteins for IKZF4 Gene

  • Protein details for IKZF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2S9-IKZF4_HUMAN
    Recommended name:
    Zinc finger protein Eos
    Protein Accession:
    Q9H2S9
    Secondary Accessions:
    • Q96JP3

    Protein attributes for IKZF4 Gene

    Size:
    585 amino acids
    Molecular mass:
    64106 Da
    Quaternary structure:
    • Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 and IKZF5. Interacts with CTBP2. Interacts with SPI1, MITF, FOXP3 and CTBP1 (By similarity).
    Miscellaneous:
    • Eos means rising sun in Greek.
    SequenceCaution:
    • Sequence=AAG39221.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB47411.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IKZF4 Gene

    Alternative splice isoforms for IKZF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IKZF4 Gene

Post-translational modifications for IKZF4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IKZF4 Gene

Domains & Families for IKZF4 Gene

Gene Families for IKZF4 Gene

Protein Domains for IKZF4 Gene

Suggested Antigen Peptide Sequences for IKZF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2S9

UniProtKB/Swiss-Prot:

IKZF4_HUMAN :
  • The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.
  • Belongs to the Ikaros C2H2-type zinc-finger protein family.
Domain:
  • The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.
  • C-terminal zinc fingers mediate homodimerization.
Family:
  • Belongs to the Ikaros C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with IKZF4: view

Function for IKZF4 Gene

Molecular function for IKZF4 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that binds to the 5GGGAATRCC-3 Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity).

Gene Ontology (GO) - Molecular Function for IKZF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 10978333
GO:0008270 zinc ion binding IMP 15491138
GO:0019904 protein domain specific binding IPI 15491138
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with IKZF4: view
genes like me logo Genes that share phenotypes with IKZF4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IKZF4 Gene

Localization for IKZF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IKZF4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IKZF4 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for IKZF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10978333
GO:0005654 nucleoplasm IDA --
GO:0016604 nuclear body IDA --
GO:0043234 protein complex IMP 15491138
genes like me logo Genes that share ontologies with IKZF4: view

Pathways & Interactions for IKZF4 Gene

SuperPathways for IKZF4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IKZF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated TAS 10978333
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
GO:0051260 protein homooligomerization IMP 15491138
genes like me logo Genes that share ontologies with IKZF4: view

No data available for Pathways by source and SIGNOR curated interactions for IKZF4 Gene

Transcripts for IKZF4 Gene

Unigene Clusters for IKZF4 Gene

IKAROS family zinc finger 4 (Eos):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IKZF4 Gene

No ASD Table

Relevant External Links for IKZF4 Gene

GeneLoc Exon Structure for
IKZF4
ECgene alternative splicing isoforms for
IKZF4

Expression for IKZF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IKZF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IKZF4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IKZF4 Gene



Protein tissue co-expression partners for IKZF4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IKZF4 Gene:

IKZF4

SOURCE GeneReport for Unigene cluster for IKZF4 Gene:

Hs.553221

mRNA Expression by UniProt/SwissProt for IKZF4 Gene:

Q9H2S9-IKZF4_HUMAN
Tissue specificity: Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver, and spleen. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.

Evidence on tissue expression from TISSUES for IKZF4 Gene

  • Nervous system(4.5)
  • Blood(2)
genes like me logo Genes that share expression patterns with IKZF4: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IKZF4 Gene

Orthologs for IKZF4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IKZF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IKZF4 34 35
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia IKZF4 34 35
  • 94.93 (n)
cow
(Bos Taurus)
Mammalia IKZF4 35 34
  • 93.56 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ikzf4 34 16 35
  • 92.42 (n)
oppossum
(Monodelphis domestica)
Mammalia IKZF4 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 74 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
chicken
(Gallus gallus)
Aves IKZF4 34
  • 80.75 (n)
lizard
(Anolis carolinensis)
Reptilia IKZF4 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ikzf4 34
  • 74.15 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-166n8.9 34
  • 65.26 (n)
IKZF4 35
  • 57 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STP1 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10790 35
  • 26 (a)
OneToMany
Species where no ortholog for IKZF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IKZF4 Gene

ENSEMBL:
Gene Tree for IKZF4 (if available)
TreeFam:
Gene Tree for IKZF4 (if available)

Paralogs for IKZF4 Gene

Variants for IKZF4 Gene

Sequence variations from dbSNP and Humsavar for IKZF4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000101620 -- 56,026,080(+) ACAGG(C/G)GTACA intron-variant, upstream-variant-2KB
rs1000200670 -- 56,027,699(+) GCAAG(A/G)TAGGG intron-variant
rs1000219368 -- 56,019,782(+) TACTC(A/C)TGGAG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000382000 -- 56,012,713(+) TGGTG(A/G)GAAAT intron-variant
rs1000416922 -- 56,017,617(+) GGGGA(A/G)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IKZF4 Gene

Variant ID Type Subtype PubMed ID
nsv1051961 CNV gain 25217958
nsv1119959 CNV deletion 24896259
nsv1138138 CNV deletion 24896259
nsv832424 CNV loss 17160897
nsv832427 CNV loss 17160897

Variation tolerance for IKZF4 Gene

Residual Variation Intolerance Score: 76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IKZF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IKZF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IKZF4 Gene

Disorders for IKZF4 Gene

Relevant External Links for IKZF4

Genetic Association Database (GAD)
IKZF4
Human Genome Epidemiology (HuGE) Navigator
IKZF4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IKZF4

No disorders were found for IKZF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IKZF4 Gene

Publications for IKZF4 Gene

  1. Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PMID: 10978333) Perdomo J. … Crossley M. (J. Biol. Chem. 2000) 2 3 4 22 64
  2. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. (PMID: 20596022) Petukhova L. … Christiano A.M. (Nature 2010) 3 46 64
  3. A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. (PMID: 18198356) Hakonarson H. … Polychronakos C. (Diabetes 2008) 3 46 64
  4. The Ikaros family protein Eos associates with C-terminal-binding protein corepressors. (PMID: 12444977) Perdomo J. … Crossley M. (Eur. J. Biochem. 2002) 3 4 64
  5. A molecular dissection of the repression circuitry of Ikaros. (PMID: 12015313) Koipally J. … Georgopoulos K. (J. Biol. Chem. 2002) 3 4 64

Products for IKZF4 Gene

Sources for IKZF4 Gene

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