Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IKZF4 Gene

protein-coding   GIFtS: 53
GCID: GC12P056414

IKAROS Family Zinc Finger 4 (Eos)

(Previous names: zinc finger protein, subfamily 1A, 4 (Eos))
(Previous symbol: ZNFN1A4)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
IKAROS Family Zinc Finger 4 (Eos)1 2     EOS2 5
ZNFN1A41 2 3 5     KIAA17823 5
Zinc Finger Protein, Subfamily 1A, 4 (Eos)1 2     Zinc Finger Protein Eos2
Ikaros Family Zinc Finger Protein 42 3     Zinc Finger Transcription Factor Eos2

External Ids:    HGNC: 131791   Entrez Gene: 643752   Ensembl: ENSG000001234117   OMIM: 6062395   UniProtKB: Q9H2S93   

Export aliases for IKZF4 gene to outside databases

Previous GC identifers: GC12P054705 GC12P053453


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for IKZF4 Gene:
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in
lymphocytes and are implicated in the control of lymphoid development.(supplied by OMIM, Jul 2002)

GeneCards Summary for IKZF4 Gene:
IKZF4 (IKAROS family zinc finger 4 (Eos)) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is IKZF5.

UniProtKB/Swiss-Prot: IKZF4_HUMAN, Q9H2S9
Function: DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor.
Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of
corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems

Gene Wiki entry for IKZF4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IKZF4 gene promoter:
         GATA-3   STAT5A   AP-2gamma   GATA-2   GATA-1   FAC1   Nkx6-1   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIKZF4 promoter sequence
   Search Chromatin IP Primers for IKZF4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IKZF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13

IKZF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IKZF4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P056414:  view genomic region     (about GC identifiers)

Start:
56,401,443 bp from pter      End:
56,432,219 bp from pter
Size:
30,777 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IKZF4_HUMAN, Q9H2S9 (See protein sequence)
Recommended Name: Zinc finger protein Eos  
Size: 585 amino acids; 64106 Da
Subunit: Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 AND IKZF5. Interacts with
CTBP2, SPI1 and MITF (By similarity)
Miscellaneous: 'Eos' means 'rising sun' in Greek
Sequence caution: Sequence=AAG39221.1; Type=Erroneous initiation; Sequence=BAB47411.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for IKZF4:
2MA7 (3D)    
Secondary accessions: Q96JP3
Alternative splicing: 2 isoforms:  Q9H2S9-1   Q9H2S9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IKZF4: NX_Q9H2S9

Explore proteomics data for IKZF4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IKZF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071910.3  
    ENSEMBL proteins: 
     ENSP00000262032   ENSP00000449168   ENSP00000449857   ENSP00000448419   ENSP00000450020  
     ENSP00000412101  

    IKZF4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IKZF4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IKZF4
    GenScript Custom Purified and Recombinant Proteins Services for IKZF4
    Novus Biologicals IKZF4 Proteins
    Novus Biologicals IKZF4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IKZF4

     
    Search eBioscience for Proteins for IKZF4 

    IKZF4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for IKZF4
    OriGene Custom Antibody Services for IKZF4
    Novus Biologicals IKZF4 Antibodies
    Abcam antibodies for IKZF4
    Cloud-Clone Corp. Antibodies for IKZF4
    Search ThermoFisher Antibodies for IKZF4
    LSBio Antibodies in human, mouse, rat for IKZF4

    IKZF4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IKZF4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IKZF4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IKZF4
    Cloud-Clone Corp. CLIAs for IKZF4
    Search eBioscience for ELISAs for IKZF4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    IKZF: IKAROS zinc fingers
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H2S9

    ProtoNet protein and cluster: Q9H2S9

    UniProtKB/Swiss-Prot: IKZF4_HUMAN, Q9H2S9
    Domain: The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations
    with other family members
    Domain: C-terminal zinc fingers mediate homodimerization
    Similarity: Belongs to the Ikaros C2H2-type zinc-finger protein family
    Similarity: Contains 6 C2H2-type zinc fingers


    Find genes that share domains with IKZF4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IKZF4_HUMAN, Q9H2S9
    Function: DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor.
    Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of
    corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS10978333
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity IEA--
         
    Find genes that share ontologies with IKZF4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IKZF4:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IKZF4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IKZF4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IKZF4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IKZF4

    miRNA
    Products:
        
    miRTarBase miRNAs that target IKZF4:
    hsa-mir-16-5p (MIRT051190), hsa-mir-93-5p (MIRT028174), hsa-mir-30b-5p (MIRT046120), hsa-mir-30c-5p (MIRT047855), hsa-mir-32-5p (MIRT049855), hsa-mir-130b-3p (MIRT020311)

    Block miRNA regulation of human, mouse, rat IKZF4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IKZF4 (see all 123):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-106a hsa-miR-371-5p hsa-miR-519a hsa-miR-3162-5p hsa-miR-1304 hsa-miR-629*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IKZF4
    Predesigned siRNA for gene silencing in human, mouse, rat IKZF4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IKZF4

    Clone
    Products:
         
    OriGene clones in human, mouse for IKZF4 (see all 7)
    OriGene ORF clones in mouse, rat for IKZF4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IKZF4 (NM_022465)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IKZF4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKZF4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IKZF4
    Browse ESI BIO Cell Lines and PureStem Progenitors for IKZF4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKZF4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    IKZF4_HUMAN, Q9H2S9: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10978333

    Find genes that share ontologies with IKZF4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IKZF4
    Interactions:

        Search GeneGlobe Interaction Network for IKZF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for IKZF4 (Q9H2S93 ENSP000002620324) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIN3BO751823, ENSP000003691314I2D: score=2 STRING: ENSP00000369131
    FOXP3Q9BZS13, ENSP000003653804I2D: score=1 STRING: ENSP00000365380
    HDAC4P565243, ENSP000002646064I2D: score=1 STRING: ENSP00000264606
    IKZF2Q9UKS73, ENSP000004104474I2D: score=1 STRING: ENSP00000410447
    IKZF1Q134223, ENSP000003316144I2D: score=2 STRING: ENSP00000331614
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0045892negative regulation of transcription, DNA-templated TAS10978333

    Find genes that share ontologies with IKZF4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IKZF4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for IKZF4 gene: 
    NM_022465.3  

    Unigene Cluster for IKZF4:

    IKAROS family zinc finger 4 (Eos)
    Hs.553221  [show with all ESTs]
    Unigene Representative Sequence: NM_022465
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262032(uc010sqa.1 uc001sjb.1 uc001sjc.1 uc001sjd.1 uc009zoi.1 uc001sje.1)
    ENST00000548601 ENST00000550860 ENST00000552689 ENST00000549519 ENST00000551103
    ENST00000547167 ENST00000547791 ENST00000547668 ENST00000551701 ENST00000551124
    ENST00000547556 ENST00000431367
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IKZF4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IKZF4 (see all 123):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-106a hsa-miR-371-5p hsa-miR-519a hsa-miR-3162-5p hsa-miR-1304 hsa-miR-629*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IKZF4
    Predesigned siRNA for gene silencing in human, mouse, rat IKZF4
    Clone
    Products:
         
    OriGene clones in human, mouse for IKZF4 (see all 7)
    OriGene ORF clones in mouse, rat for IKZF4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IKZF4 (NM_022465)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IKZF4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKZF4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IKZF4
    OriGene qSTAR qPCR primer pairs in human, mouse for IKZF4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IKZF4
      QuantiTect SYBR Green Assays in human, mouse, rat IKZF4
      QuantiFast Probe-based Assays in human, mouse, rat IKZF4

    Additional mRNA sequence: 

    AB058685.1 AF230809.1 AK055063.1 AK055970.1 AK122880.1 AK314543.1 BX647761.1 

    6 DOTS entries:

    DT.442819  DT.100741553  DT.121175828  DT.97829504  DT.121175829  DT.40128891 

    Selected AceView cDNA sequences (see all 100):

    BM675032 AI346934 AA603643 AW772649 AK055970 AW071737 BF435416 AI767303 
    AI990392 H30802 AI861774 AI857519 AW014357 BX647761 BM682475 AW193810 
    CK430142 CK819495 NM_022465 BM675405 BX118741 AK055063 AW518574 AI014969 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IKZF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTAATTTAA
    IKZF4 Expression
    About this image


    IKZF4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Endothelium (Cardiovascular System)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Thyroid (Endocrine System)
    IKZF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IKZF4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553221

    UniProtKB/Swiss-Prot: IKZF4_HUMAN, Q9H2S9
    Tissue specificity: Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver,
    and spleen. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and
    M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively

        Custom PCR Arrays for IKZF4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IKZF4
    OriGene qSTAR qPCR primer pairs in human, mouse for IKZF4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IKZF4
    QuantiTect SYBR Green Assays in human, mouse, rat IKZF4
    QuantiFast Probe-based Assays in human, mouse, rat IKZF4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKZF4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for IKZF4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ikzf41 , 5 IKAROS family zinc finger 41, 5 92.42(n)1
    96.92(a)1
      10 (77.11 cM)5
    227811  NM_011772.21  NP_035902.21 
     1286308435 
    chicken
    (Gallus gallus)
    Aves IKZF41 IKAROS family zinc finger 4 (Eos) 80.75(n)
    89.17(a)
      101747801  XM_004949736.1  XP_004949793.1 
    lizard
    (Anolis carolinensis)
    Reptilia IKZF46
    IKAROS family zinc finger 4 (Eos)
    80(a)
    1 ↔ 1
    GL343198.1(3529307-3544473)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ikzf41 IKAROS family zinc finger 4 (Eos) 74.15(n)
    78.96(a)
      100496155  XM_002934532.2  XP_002934578.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-166n8.91 si:dkey-166n8.9 65.26(n)
    65.56(a)
      566844  NM_001177455.1  NP_001170926.1 


    ENSEMBL Gene Tree for IKZF4 (if available)
    TreeFam Gene Tree for IKZF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for IKZF4 gene
    IKZF52  IKZF12  IKZF32  IKZF22  
    Selected SIMAP similar genes for IKZF4 using alignment to 4 protein entries:     IKZF4_HUMAN (see all proteins) (see all similar genes):
    kr-znf3    IKZF1    ZNF55    ZNFN1A2    IKZF2    ZFS-5
    A-328A3.4    ZNF808    smap-7    IKZF3    ZNF    DKFZp434J0650
    DKFZp666C237    DKFZp686M04222    PLAGL1    ZNF78L1    ZNF844    ZNF22

    Find genes that share paralogs with IKZF4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for IKZF4 (see all 373)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1403269631,2
    --56412766(+) GGAGGC/TCGAGG 1 -- us2k10--------
    rs1454719331,2
    C--56412794(+) CAAGAA/GATCAG 1 -- us2k10--------
    rs111717231,2
    C,H--56413049(+) TATCAG/AAAACC 1 -- us2k16Minor allele frequency- A:0.00NS EA NA 488
    rs1407671701,2
    --56413126(+) ATTGGC/TATGCA 1 -- us2k10--------
    rs1919080991,2
    --56413161(+) AGACAC/TACATA 1 -- us2k10--------
    rs733383441,2
    C,F--56413356(+) GCCTTG/CTGAGG 1 -- us2k12Minor allele frequency- C:0.02WA 120
    rs1827197091,2
    C--56413364(+) AGGAGC/TGAGCC 1 -- us2k10--------
    rs1870831221,2
    C--56413588(+) CACCGC/TGCTAT 1 -- us2k10--------
    rs1501272911,2
    C--56413766(+) TAAGGA/CTACCA 1 -- us2k10--------
    rs1160636091,2
    F--56413851(+) CATATG/AGAAGC 1 -- us2k11Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for IKZF4 (56401443 - 56432219 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IKZF4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832427CNV Loss17160897
    nsv832424CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IKZF4
    DNA2.0 Custom Variant and Variant Library Synthesis for IKZF4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606239    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for IKZF4:
    Alopecia areata

    Find genes that share disorders with IKZF4           About GenesLikeMe

    Genetic Association Database (GAD): IKZF4
    Human Genome Epidemiology (HuGE) Navigator: IKZF4 (3 documents)

    Export disorders for IKZF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IKZF4 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with IKZF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PubMed id 10978333)1, 2, 3, 9 Perdomo J.... Crossley M. (J. Biol. Chem. 2000)
    2. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. (PubMed id 20596022)1, 4 Petukhova L....Christiano A.M. (Nature 2010)
    3. A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. (PubMed id 18198356)1, 4 Hakonarson H....Polychronakos C. (Diabetes 2008)
    4. A molecular dissection of the repression circuitry of Ikaros. (PubMed id 12015313)1, 2 Koipally J. and Georgopoulos K. (J. Biol. Chem. 2002)
    5. The Ikaros family protein Eos associates with C-terminal-binding protein corepressors. (PubMed id 12444977)1, 2 Perdomo J. and Crossley M. (Eur. J. Biochem. 2002)
    6. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    7. Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population. (PubMed id 22951725)1 Tang X.F....Zhang X.J. (J. Invest. Dermatol. 2013)
    8. Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. (PubMed id 22561518)1 Jin Y....Spritz R.A. (Nat. Genet. 2012)
    9. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PubMed id 21829393)1 Plagnol V....Todd J.A. (PLoS Genet. 2011)
    10. Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. (PubMed id 21804548)1 Hirota T....Tamari M. (Nat. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 64375 HGNC: 13179 AceView: ZNFN1A4 Ensembl:ENSG00000123411 euGenes: HUgn64375
    ECgene: IKZF4 H-InvDB: IKZF4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1782

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IKZF4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IKZF4 gene:
    Search GeneIP for patents involving IKZF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for IKZF4   OriGene RNAi products in human, mouse, rat for IKZF4  
     OriGene qPCR primer pairs and template standards for IKZF4   OriGene Protein Over-expression Lysate for IKZF4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for IKZF4  
     OriGene qSTAR qPCR primer pairs in human, mouse for IKZF4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for IKZF4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IKZF4   OriGene Custom Protein Services for IKZF4  

     
     
     Block miRNA regulation of human, mouse, rat IKZF4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IKZF4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IKZF4 Predesigned siRNA for gene silencing in human, mouse, rat IKZF4
     QuantiFast Probe-based Assays in human, mouse, rat IKZF4 QuantiTect SYBR Green Assays in human, mouse, rat IKZF4
     Custom PCR Arrays for IKZF4 Search Chromatin IP Primers for IKZF4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IKZF4  Search GeneGlobe Interaction Network for IKZF4
     Regulatory tfbs in IKZF4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for IKZF4 GenScript cDNA clones with any tag delivered in your preferred vector for IKZF4
     GenScript Custom Assay Services for IKZF4 GenScript Custom overexpressing Cell Line Services for IKZF4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for IKZF4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IKZF4 antibodies
     IKZF4 proteins
     IKZF4 lysates
     Antibodies for IKZF4
     See all of Abcam's Antibodies, Kits and Proteins for IKZF4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for IKZF4
     Antibodies for IKZF4
     ELISAs for IKZF4
     CLIAs for IKZF4



     Browse ESI BIO Cell Lines and PureStem Progenitors for IKZF4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKZF4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for IKZF4
     SwitchGear Promoter luciferase reporter plasmids for IKZF4
     Search ThermoFisher Antibodies for IKZF4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKZF4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IKZF4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IKZF4
     LSBio Antibodies in human, mouse, rat for IKZF4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for IKZF4
      Search eBioscience for proteins for IKZF4
      Search eBioscience for elisas for IKZF4
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IKZF4 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4