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Aliases for IKZF3 Gene

Aliases for IKZF3 Gene

  • IKAROS Family Zinc Finger 3 (Aiolos) 2 3
  • ZNFN1A3 3 4 6
  • Zinc Finger Protein, Subfamily 1A, 3 (Aiolos) 2 3
  • AIOLOS 3 6
  • Zinc Finger DNA Binding Protein Aiolos 3
  • Ikaros Family Zinc Finger Protein 3 4
  • Zinc Finger Protein Aiolos 3
  • AIO 3

External Ids for IKZF3 Gene

Previous Symbols for IKZF3 Gene

  • ZNFN1A3

Summaries for IKZF3 Gene

Entrez Gene Summary for IKZF3 Gene

  • This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]

GeneCards Summary for IKZF3 Gene

IKZF3 (IKAROS Family Zinc Finger 3 (Aiolos)) is a Protein Coding gene. Diseases associated with IKZF3 include oophoritis. Among its related pathways are Lymphocyte Signaling and IL2-mediated signaling events. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is IKZF2.

UniProtKB/Swiss-Prot for IKZF3 Gene

  • Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.

Gene Wiki entry for IKZF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IKZF3 Gene

Genomics for IKZF3 Gene

Genomic Location for IKZF3 Gene

Start:
39,757,715 bp from pter
End:
39,864,188 bp from pter
Size:
106,474 bases
Orientation:
Minus strand

Genomic View for IKZF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IKZF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IKZF3 Gene

Regulatory Elements for IKZF3 Gene

Proteins for IKZF3 Gene

  • Protein details for IKZF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKT9-IKZF3_HUMAN
    Recommended name:
    Zinc finger protein Aiolos
    Protein Accession:
    Q9UKT9
    Secondary Accessions:
    • B4DVV5
    • Q69BL6
    • Q69BL7
    • Q69BL8
    • Q69BL9
    • Q69BM0
    • Q69BM1
    • Q69BM2
    • Q69BM3
    • Q69BM5
    • Q8N574
    • Q8WWQ9
    • Q8WWR0
    • Q8WWR1
    • Q8WWR2
    • Q8WWR3

    Protein attributes for IKZF3 Gene

    Size:
    509 amino acids
    Molecular mass:
    58023 Da
    Quaternary structure:
    • Homodimer, and heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5. Interacts with IKZF1. Interacts with HRAS. Interacts with FOXP3; this interaction may be required for silencing target genes and regulating the suppressive activity of FOXP3-positive regulatory T-cells (Treg). Interacts with BCL21L isoform Bcl-X(L); this interaction blocks the anti-apoptotic role of BCL21L. Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A.

neXtProt entry for IKZF3 Gene

Proteomics data for IKZF3 Gene at MOPED

Post-translational modifications for IKZF3 Gene

  • Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys158

No data available for DME Specific Peptides for IKZF3 Gene

Domains for IKZF3 Gene

Gene Families for IKZF3 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • IKZF :IKAROS zinc fingers

Protein Domains for IKZF3 Gene

UniProtKB/Swiss-Prot:

IKZF3_HUMAN
Family:
  • Belongs to the Ikaros C2H2-type zinc-finger protein family.:
    • Q9UKT9
Similarity:
  • Contains 6 C2H2-type zinc fingers.:
    • Q9UKT9
genes like me logo Genes that share domains with IKZF3: view

Function for IKZF3 Gene

Molecular function for IKZF3 Gene

UniProtKB/Swiss-Prot Function: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
UniProtKB/Swiss-Prot Induction: Up-regulated by TGFB1 and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in activated AHR T-cells.

Gene Ontology (GO) - Molecular Function for IKZF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 10552935
GO:0005515 protein binding IPI 10369681
GO:0042803 protein homodimerization activity IDA 17646674
GO:0043565 sequence-specific DNA binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with IKZF3: view
genes like me logo Genes that share phenotypes with IKZF3: view

Animal Models for IKZF3 Gene

MGI Knock Outs for IKZF3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IKZF3 Gene

Localization for IKZF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IKZF3 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IKZF3 Gene COMPARTMENTS Subcellular localization image for IKZF3 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for IKZF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with IKZF3: view

Pathways for IKZF3 Gene

genes like me logo Genes that share pathways with IKZF3: view

Pathways by source for IKZF3 Gene

1 Cell Signaling Technology pathway for IKZF3 Gene
1 BioSystems pathway for IKZF3 Gene

Gene Ontology (GO) - Biological Process for IKZF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10552935
GO:0007498 mesoderm development TAS 10552935
GO:0030888 regulation of B cell proliferation ISS --
GO:0042113 B cell activation IEA --
genes like me logo Genes that share ontologies with IKZF3: view

Compounds for IKZF3 Gene

(1) Novoseek inferred chemical compound relationships for IKZF3 Gene

Compound -log(P) Hits PubMed IDs
zinc 49.4 5
genes like me logo Genes that share compounds with IKZF3: view

Transcripts for IKZF3 Gene

Unigene Clusters for IKZF3 Gene

IKAROS family zinc finger 3 (Aiolos):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IKZF3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - - - -
SP9: - - - -
SP10: - - - -
SP11: - -
SP12: - - - - - -
SP13: - - - - - -
SP14: - - - - -
SP15: - - - - -
SP16: - - - - - - -
SP17: -

Relevant External Links for IKZF3 Gene

GeneLoc Exon Structure for
IKZF3
ECgene alternative splicing isoforms for
IKZF3

Expression for IKZF3 Gene

mRNA expression in normal human tissues for IKZF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IKZF3 Gene

This gene is overexpressed in Whole Blood (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IKZF3 Gene

SOURCE GeneReport for Unigene cluster for IKZF3 Gene Hs.371680

mRNA Expression by UniProt/SwissProt for IKZF3 Gene

Q9UKT9-IKZF3_HUMAN
Tissue specificity: Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.
genes like me logo Genes that share expressions with IKZF3: view

Orthologs for IKZF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IKZF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IKZF3 36
  • 99.54 (n)
  • 99.41 (a)
IKZF3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IKZF3 36
  • 92.99 (n)
  • 93.52 (a)
IKZF3 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IKZF3 36
  • 91.88 (n)
  • 92.93 (a)
IKZF3 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ikzf3 36
  • 86.19 (n)
  • 86.98 (a)
Ikzf3 16
Ikzf3 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IKZF3 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IKZF3 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ikzf3 36
  • 86.02 (n)
  • 87.99 (a)
chicken
(Gallus gallus)
Aves AIOLOS 37
  • 75 (a)
OneToOne
IKZF3 36
  • 74.27 (n)
  • 75.15 (a)
lizard
(Anolis carolinensis)
Reptilia IKZF3 37
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ikzf3 36
  • 62.32 (n)
  • 58.52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10790 37
  • 25 (a)
OneToMany
Species with no ortholog for IKZF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IKZF3 Gene

ENSEMBL:
Gene Tree for IKZF3 (if available)
TreeFam:
Gene Tree for IKZF3 (if available)

Paralogs for IKZF3 Gene

Paralogs for IKZF3 Gene

Selected SIMAP similar genes for IKZF3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IKZF3: view

Variants for IKZF3 Gene

Sequence variations from dbSNP and Humsavar for IKZF3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs907091 -- 39,765,489(+) ATCTC(C/T)GGGAC utr-variant-3-prime
rs907092 -- 39,766,006(+) TTGAC(A/G)GAGTC reference, synonymous-codon
rs935964 -- 39,860,175(-) CCTCC(A/T)GCCTC intron-variant
rs1006534 -- 39,864,282(+) AGGGC(A/G)GGAGC upstream-variant-2KB
rs1105719 -- 39,864,446(+) AATTG(C/T)CTCAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IKZF3 Gene

Variant ID Type Subtype PubMed ID
nsv908207 CNV Loss 21882294
esv2659729 CNV Deletion 23128226
esv2715904 CNV Deletion 23290073
esv1009212 CNV Deletion 20482838
esv1483215 CNV Deletion 17803354

Relevant External Links for IKZF3 Gene

HapMap Linkage Disequilibrium report
IKZF3

Disorders for IKZF3 Gene

(1) MalaCards Diseases for IKZF3 Gene

Search for IKZF3 Gene in MalaCards »

(2) University of Copenhagen DISEASES for IKZF3 Gene

(4) Novoseek inferred disease relationships for IKZF3 Gene

Disease -log(P) Hits PubMed IDs
leukemia 33.8 7
lymphoblastic leukemia acute 24.3 1
lymphoma 22.7 3
tumors 0 2

Relevant External Links for IKZF3

Genetic Association Database (GAD)
IKZF3
Human Genome Epidemiology (HuGE) Navigator
IKZF3
genes like me logo Genes that share disorders with IKZF3: view

No data available for UniProtKB/Swiss-Prot for IKZF3 Gene

Publications for IKZF3 Gene

  1. Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping. (PMID: 10552935) Hosokawa Y. … Seto M. (Genomics 1999) 2 3 4 23
  2. Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization. (PMID: 10369681) Romero F. … Rebollo A. (EMBO J. 1999) 3 4 23
  3. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. (PMID: 9155026) Morgan B. … Georgopoulos K. (EMBO J. 1997) 2 3 23
  4. Both normal and leukemic B lymphocytes express multiple isoforms of the human Aiolos gene. (PMID: 11745366) Liippo J.P. … Lassila O. (Eur. J. Immunol. 2001) 3 4 23
  5. Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PMID: 10978333) Perdomo J. … Crossley M. (J. Biol. Chem. 2000) 3 4 23

Products for IKZF3 Gene

Sources for IKZF3 Gene

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