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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IKZF3 Gene

protein-coding GIFtS: 53
GCID: GC17M037921

IKAROS family zinc finger 3 (Aiolos)

(Previous names: zinc finger protein, subfamily 1A, 3 (Aiolos) )
(Previous symbol: ZNFN1A3)

Explore 17 diseases affiliated with
IKZF3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
IKAROS Family Zinc Finger 3 (Aiolos)¹ ²		Aiolos¹
ZNFN1A3¹ ² ³ ⁵		AIO²
Zinc Finger Protein, Subfamily 1A, 3 (Aiolos)¹ ²		Zinc Finger Protein Aiolos²
AIOLOS² ⁵		Ikaros Family Zinc Finger Protein 3³

External Ids:	HGNC: 13178¹	Entrez Gene: 22806²	Ensembl: ENSG00000161405⁷	OMIM: 606221⁵	UniProtKB: Q9UKT9³

Export aliases for IKZF3 gene to outside databases

Previous GC identifers: GC17M035175 GC17M037913 GC17M033714

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IKZF3:

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros,

Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte

development. This gene product is a transcription factor that is important in the regulation of B lymphocyte

proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene

expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros

homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different

isoforms have been described, as well as some non-protein coding variants. (provided by RefSeq, Apr 2012)

UniProtKB/Swiss-Prot: IKZF3_HUMAN, Q9UKT9

Function: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an

essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in

regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner

Gene Wiki entry for IKZF3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IKZF3 gene promoter:
SRF Pax-5 AML1a MAZR SRF (504 AA) ATF-2 RORalpha2 FAC1 E2F
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IKZF3 promoter sequence

Search SABiosciences Chromatin IP Primers for IKZF3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IKZF3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q11.2

IKZF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IKZF3 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M037921: view genomic region (about GC identifiers)

Start:	37,921,198 bp from pter	End:	38,020,441 bp from pter
Size:	99,244 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IKZF3_HUMAN, Q9UKT9 (See protein sequence)

Recommended Name: Zinc finger protein Aiolos

Size: 509 amino acids; 58023 Da

Subunit: Homodimer, and heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5. Interacts with

IKZF1. Interacts with HRAS. Interacts with FOXP3; this interaction may be required for silencing target genes and

regulating the suppressive activity of FOXP3-positive regulatory T-cells (Treg). Interacts with BCL21L isoform

Bcl-X(L); this interaction blocks the anti-apoptotic role of BCL21L. Associates with histone deacetylase complexes

containing HDAC1, MTA2 and SIN3A

Subcellular location: Nucleus. Cytoplasm

Secondary accessions: Q69BL6 Q69BL7 Q69BL8 Q69BL9 Q69BM0 Q69BM1 Q69BM2 Q69BM3 Q69BM5 Q8N574 Q8WWQ9

Q8WWR0 Q8WWR1 Q8WWR2 Q8WWR3

Alternative splicing: 15 isoforms: Q9UKT9-1 Q9UKT9-2 Q9UKT9-3 Q9UKT9-4 Q9UKT9-5 Q9UKT9-6 Q9UKT9-7 Q9UKT9-8

Q9UKT9-9 Q9UKT9-10 Q9UKT9-11 Q9UKT9-12 Q9UKT9-13 Q9UKT9-14 Q9UKT9-15

Explore the universe of human proteins at neXtProt for IKZF3: NX_Q9UKT9

Post-translational modifications:

Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of

IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in

T-cells¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UKT9

IKZF3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (13 alternative transcripts):

NP_001244337.1 NP_001244338.1 NP_001244339.1 NP_001244340.1 NP_001244341.1 NP_001244342.1 NP_001244343.1 NP_036613.2

NP_899051.1 NP_899052.1 NP_899053.1 NP_899054.1 NP_899055.1

ENSEMBL proteins:

ENSP00000344544 ENSP00000403776 ENSP00000463505 ENSP00000462791 ENSP00000367180

ENSP00000377741 ENSP00000367179 ENSP00000367194 ENSP00000438972 ENSP00000367188

ENSP00000462452 ENSP00000345622 ENSP00000341977 ENSP00000344471 ENSP00000420463

ENSP00000403027

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	Uscn Proteins for IKZF3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	IDA	--

IKZF3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for IKZF3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IKZF3 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q9UKT9

ProtoNet protein and cluster: Q9UKT9

UniProtKB/Swiss-Prot: IKZF3_HUMAN, Q9UKT9

Similarity: Belongs to the Ikaros C2H2-type zinc-finger protein family

Similarity: Contains 6 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IKZF3_HUMAN, Q9UKT9

Function: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an

essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in

regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner

Induction: Up-regulated by TGFB1 and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in activated AHR T-cells

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKZF3

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	10552935
GO:0005515	protein binding	IPI	--
GO:0008270	zinc ion binding	IEA	--
GO:0042803	protein homodimerization activity	IDA	17646674
GO:0043565	sequence-specific DNA binding	ISS	--

IKZF3 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Ikzf3^tm1Kge for IKZF3
     7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ikzf3):

cellular	hematopoietic system	homeostasis/metabolism	immune system	mortality/aging
renal/urinary system	tumorigenesis

IKZF3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

IL-2 Signaling Pathway

IL2-mediated signaling events

0.42

1 BioSystems Pathway for IKZF3

IL2-mediated signaling events

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IKZF3

5/30 Interacting proteins for IKZF3 (Q9UKT9^{1, 2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FOXP3	Q9BZS1¹^,³	EBI-747204,EBI-983719 I2D: score=1
UBE2I	P63279³	I2D: score=6
HRAS	P01112³	I2D: score=3
BCL2L1	Q07817³	I2D: score=2
IKZF4	Q9H2S9³	I2D: score=2

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	10552935
GO:0007498	mesoderm development	TAS	10552935
GO:0030888	regulation of B cell proliferation	ISS	--
GO:0042113	B cell activation	IEA	--

IKZF3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IKZF3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IKZF3
1 Novoseek chemical compound relationship for IKZF3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	49.4	5	10552935 (1), 12574333 (1), 17018618 (1), 18184862 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about IKZF3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IKZF3 gene (13 alternative transcripts):

NM_001257408.1 NM_001257409.1 NM_001257410.1 NM_001257411.1 NM_001257412.1 NM_001257413.1 NM_001257414.1 NM_012481.4

NM_183228.2 NM_183229.2 NM_183230.2 NM_183231.2 NM_183232.2

Unigene Cluster for IKZF3:

IKAROS family zinc finger 3 (Aiolos)

Hs.371680 [show with all ESTs]

Unigene Representative Sequence: NR_047559

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000346872(uc010wel.2 uc002hsu.3 uc002htd.3 uc010cwd.3 uc002hsv.3 uc010cwe.3 uc010cwf.3 uc010cwg.3 uc002hsw.3 uc002hsx.3 uc002hsy.3 uc002hsz.3 uc002hta.3 uc002htb.3 uc010cwh.3 uc002htc.3)

ENST00000439167 ENST00000348427 ENST00000293068 ENST00000377945 ENST00000394189

ENST00000377944 ENST00000377958 ENST00000535189 ENST00000377952 ENST00000583368

ENST00000351680 ENST00000346243 ENST00000350532 ENST00000467757 ENST00000439016

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Additional cDNA sequence:

AF086054.1 AF129512.1 AJ292565.1 AJ292566.1 AJ292567.1 AJ292568.1 AJ292569.1 AJ308023.1

AK128436.1 AK301250.1 AK303495.1 AY377973.1 AY377975.1 AY377976.1 AY377977.1 AY377978.1

AY377979.1 AY377980.1 AY377981.1 AY377982.1 BC012267.1 BC032707.1 NR_047559.1 NR_047560.1

NR_047561.1

10 DOTS entries:

DT.97810121 DT.97837816 DT.70101125 DT.97837815 DT.121004587 DT.100730524 DT.92416688 DT.100647375

DT.101965498 DT.120905966

24/34 AceView cDNA sequences (see all 34):

BM458447 NM_183231 AY377973 AY377975 AY377978 AY377982 AY377981 AY377979

NM_012481 AW071111 NM_183228 BC032707 AY377977 NM_183230 AY377980 NM_183232

AY377976 NM_183229 CD703845 AJ292566 BX486691 AI660183 CD641253 AJ292567

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for IKZF3 (see all 17) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	·	9c
SP1:															-						-
SP2:															-		-				-
SP3:											-				-						-
SP4:									-						-		-				-
SP5:							-								-		-				-

ECgene alternative splicing isoforms for IKZF3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IKZF3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTTTAAATA

About this image

IKZF3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Body Subcutaneous White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Intermediate limb mesenchymal cells (ILM cells) (Primary Cell)

Bone, Cartilage, Limb

See IKZF3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IKZF3

SOURCE GeneReport for Unigene cluster: Hs.371680

UniProtKB/Swiss-Prot: IKZF3_HUMAN, Q9UKT9

Tissue specificity: Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus

SABiosciences Expression via Pathway-Focused PCR Array including IKZF3:

Leukemia in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IKZF3 gene from 2/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	IKZF3¹	IKAROS family zinc finger 3 (Aiolos)	74.04(n) 73.89(a)		395614 NM_204820.1 NP_990151.1
lizard (Anolis carolinensis)	Reptilia	IKZF3⁶	--	68(a)	1 ↔ 1	6(68558456-68582172)

ENSEMBL Gene Tree for IKZF3 (if available)
TreeFam Gene Tree for IKZF3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IKZF3 gene

IKZF4² IKZF5² IKZF1² IKZF2² TRPS1²

15 SIMAP similar genes for IKZF3 using alignment to 2 protein entries: IKZF3_HUMAN (see all proteins):

IKZF1 ZNF808 ZNF844 ZNF ZNF833P ZNFN1A2

IKZF2 ZNF697 ZNF702P IKZF4 ZNF32 ZNF72

PLZF ZNF323 ZNF589

IKZF3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2952143^1,2	C,H,	--	37913486(+)	`CTCCAA/GGTATC`	16	--	ds500¹ int¹		14		NA WA CSA EA	379
rs141230309^1,2		--	37913546(+)	`TCCCAA/GTGTGG`	16	--	ds500¹ int¹		0	--	--	--	--
rs117329794^1,2	C,F,	--	37913731(+)	`GACCAG/ATGGAA`	16	--	int¹ ds500¹		1		NA	120
rs115570946^1,2	F,	--	37913774(+)	`AGCAGC/GAGGAT`	16	--	int¹ ds500¹		1		WA	118
rs181147604^1,2		--	37913873(+)	`AGGGGA/CAAAAT`	16	--	ds500¹ int¹		0	--	--	--	--
rs185548995^1,2		--	37913899(+)	`TGGGGA/CGGGAT`	16	--	ds500¹ int¹		0	--	--	--	--
rs190204570^1,2		--	37913900(+)	`GGGGCA/GGGATG`	16	--	ds500¹ int¹		0	--	--	--	--
rs181479995^1,2		--	37913943(+)	`AAATCA/GTAAGT`	16	--	int¹ ds500¹		0	--	--	--	--
rs74744852^1,2	C,	--	37914129(+)	`AGGAGT/AAAACT`	16	--	ut3¹ nc-transcript-variant		1		EA	120
rs150181732^1,2		--	37914180(+)	`TAGGAA/GTGACG`	16	--	nc-transcript-variantut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IKZF3 (37921198 - 38020441 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IKZF3
1 Indel: 25829

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IKZF3 for disorders           About GeneDecksing

OMIM gene information: 606221    OMIM disorders: --

17 diseases for IKZF3:    About MalaCards

cleft lip/palate cleft lip non-hodgkin lymphoma primary biliary cirrhosis

lymphoblastic leukemia systemic lupus erythematosus lupus erythematosus hodgkin's lymphoma

acute lymphoblastic leukemia chronic lymphocytic leukemia lymphocytic leukemia rheumatoid arthritis

leukemia arthritis prostate cancer breast cancer

prostatitis

4 Novoseek disease relationships for IKZF3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia	33.8	8	17296582 (3), 20432734 (2), 12752680 (1), 12445735 (1)
lymphoblastic leukemia acute	24.3	1	12445735 (1)
lymphoma	22.7	3	11997672 (1), 12445735 (1), 11937265 (1)
tumors	0	3	18206652 (1), 10945610 (1)

Human Genome Epidemiology (HuGE) Navigator: IKZF3 (4 documents)

Export disorders for IKZF3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IKZF3 gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with IKZF3)

Utopia: connect your pdf to the dynamic
world of online information

Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping. (PubMed id 10552935)^{1, 2, 3, 9} Hosokawa Y.... Seto M. (1999)
Both normal and leukemic B lymphocytes express multiple isoforms of the human Aiolos gene. (PubMed id 11745366)^{1, 2, 9} Liippo J.P.... Lassila O. (2001)
Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. (PubMed id 9155026)^{1, 3, 9} Morgan B....Georgopoulos K. (1997)
Combinatorial effects of splice variants modulate function of Aiolos. (PubMed id 17646674)^{1, 2, 9} Caballero R....Ballestar E. (2007)
Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization. (PubMed id 10369681)^{1, 2, 9} Romero F....Rebollo A. (1999)
Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PubMed id 10978333)^{1, 2, 9} Perdomo J.... Crossley M. (2000)
The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis. (PubMed id 11714801)^{1, 2} Rebollo A....Zaballos A. (2001)
The Aiolos transcription factor is up-regulated in chronic lymphocytic leukemia. (PubMed id 18184862)^{1, 9} Duhamel M....Rebollo A. (2008)
Differential aiolos expression in human hematopoietic subpopulations. (PubMed id 19540588)^{1, 9} Billot K....Rebollo A. (2010)
Critical function of Ikaros in controlling Aiolos gene expression. (PubMed id 17383641)^{1, 9} Ghadiri A....Rebollo A. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 22806	HGNC: 13178	AceView: ZNFN1A3	Ensembl:ENSG00000161405	euGenes: HUgn22806
ECgene: IKZF3	H-InvDB: IKZF3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IKZF3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IKZF3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IKZF3 gene:
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IKAROS family zinc finger 3 (Aiolos)

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IKZF3 Gene

IKAROS family zinc finger 3 (Aiolos)

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