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Aliases for IKZF2 Gene

Aliases for IKZF2 Gene

  • IKAROS Family Zinc Finger 2 (Helios) 2 3
  • HELIOS 3 4 6
  • Zinc Finger Protein, Subfamily 1A, 2 (Helios) 2 3
  • Ikaros Family Zinc Finger Protein 2 3 4
  • ZNFN1A2 3 4
  • ANF1A2 3 6
  • Zinc Finger DNA Binding Protein Helios 3
  • Zinc Finger Protein Helios 3
  • ZNF1A2 3

External Ids for IKZF2 Gene

Previous Symbols for IKZF2 Gene

  • ZNFN1A2

Summaries for IKZF2 Gene

Entrez Gene Summary for IKZF2 Gene

  • This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for IKZF2 Gene

IKZF2 (IKAROS Family Zinc Finger 2 (Helios)) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is IKZF4.

UniProtKB/Swiss-Prot for IKZF2 Gene

  • Associates with Ikaros at centromeric heterochromatin

Gene Wiki entry for IKZF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IKZF2 Gene

Genomics for IKZF2 Gene

Genomic Location for IKZF2 Gene

Start:
212,999,684 bp from pter
End:
213,154,221 bp from pter
Size:
154,538 bases
Orientation:
Minus strand

Genomic View for IKZF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IKZF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IKZF2 Gene

Regulatory Elements for IKZF2 Gene

Proteins for IKZF2 Gene

  • Protein details for IKZF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKS7-IKZF2_HUMAN
    Recommended name:
    Zinc finger protein Helios
    Protein Accession:
    Q9UKS7
    Secondary Accessions:
    • Q53YJ5
    • Q6PQC5
    • Q6PQC6
    • Q6PQC7
    • Q6PQC8
    • Q6PQD0
    • Q6PQD1
    • Q8N6S1

    Protein attributes for IKZF2 Gene

    Size:
    526 amino acids
    Molecular mass:
    59574 Da
    Quaternary structure:
    • Interacts with IKZF4 AND IKZF5.

    Alternative splice isoforms for IKZF2 Gene

neXtProt entry for IKZF2 Gene

Proteomics data for IKZF2 Gene at MOPED

Post-translational modifications for IKZF2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys283 and Lys288

No data available for DME Specific Peptides for IKZF2 Gene

Domains for IKZF2 Gene

Gene Families for IKZF2 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • IKZF :IKAROS zinc fingers

Protein Domains for IKZF2 Gene

UniProtKB/Swiss-Prot:

IKZF2_HUMAN
Family:
  • Belongs to the Ikaros C2H2-type zinc-finger protein family.:
    • Q9UKS7
Similarity:
  • Contains 6 C2H2-type zinc fingers.:
    • Q9UKS7
genes like me logo Genes that share domains with IKZF2: view

Function for IKZF2 Gene

Molecular function for IKZF2 Gene

UniProtKB/Swiss-Prot Function: Associates with Ikaros at centromeric heterochromatin

Gene Ontology (GO) - Molecular Function for IKZF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 23088713
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with IKZF2: view
genes like me logo Genes that share phenotypes with IKZF2: view

Animal Models for IKZF2 Gene

MGI Knock Outs for IKZF2:

miRNA for IKZF2 Gene

miRTarBase miRNAs that target IKZF2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IKZF2 Gene

Localization for IKZF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IKZF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IKZF2 Gene COMPARTMENTS Subcellular localization image for IKZF2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for IKZF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with IKZF2: view

Pathways for IKZF2 Gene

SuperPathways for IKZF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IKZF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with IKZF2: view

No data available for Pathways by source for IKZF2 Gene

Compounds for IKZF2 Gene

(2) Novoseek inferred chemical compound relationships for IKZF2 Gene

Compound -log(P) Hits PubMed IDs
zinc 49.7 8
gold 19.3 1
genes like me logo Genes that share compounds with IKZF2: view

Transcripts for IKZF2 Gene

Unigene Clusters for IKZF2 Gene

IKAROS family zinc finger 2 (Helios):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IKZF2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - -
SP12: - - - - - - - - - - -
SP13: - - -
SP14: - - - - - -
SP15:

ExUns: 16d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for IKZF2 Gene

GeneLoc Exon Structure for
IKZF2
ECgene alternative splicing isoforms for
IKZF2

Expression for IKZF2 Gene

mRNA expression in normal human tissues for IKZF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IKZF2 Gene

This gene is overexpressed in Esophagus - Mucosa (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IKZF2 Gene

SOURCE GeneReport for Unigene cluster for IKZF2 Gene Hs.604950

genes like me logo Genes that share expressions with IKZF2: view

Orthologs for IKZF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IKZF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IKZF2 36
  • 99.94 (n)
  • 99.81 (a)
IKZF2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IKZF2 36
  • 97.59 (n)
  • 99.43 (a)
IKZF2 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IKZF2 36
  • 97.97 (n)
  • 99.05 (a)
IKZF2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ikzf2 36
  • 95.75 (n)
  • 97.91 (a)
Ikzf2 16
Ikzf2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IKZF2 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IKZF2 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ikzf2 36
  • 92.69 (n)
  • 94.86 (a)
chicken
(Gallus gallus)
Aves HELIOS 37
  • 89 (a)
OneToOne
IKZF2 36
  • 87.9 (n)
  • 89.16 (a)
lizard
(Anolis carolinensis)
Reptilia IKZF2 37
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia znfn1a1-A-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ikzf2 36
  • 76.25 (n)
  • 79.31 (a)
zebrafish
(Danio rerio)
Actinopterygii IKZF2 37
  • 55 (a)
OneToOne
si:zfos-1425h8.1 36
  • 62.04 (n)
  • 57.56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10790 37
  • 27 (a)
OneToMany
Species with no ortholog for IKZF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IKZF2 Gene

ENSEMBL:
Gene Tree for IKZF2 (if available)
TreeFam:
Gene Tree for IKZF2 (if available)

Paralogs for IKZF2 Gene

Paralogs for IKZF2 Gene

genes like me logo Genes that share paralogs with IKZF2: view

Variants for IKZF2 Gene

Sequence variations from dbSNP and Humsavar for IKZF2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs744269 -- 213,066,635(+) GGGGA(A/C)TTAAA intron-variant
rs894116 -- 213,091,167(+) GAACC(A/C)ATTAA intron-variant
rs900368 -- 213,066,548(-) CATCT(C/G)AGGGC intron-variant
rs920523 -- 213,127,534(-) AATAC(C/T)GTATC intron-variant
rs920524 -- 213,127,060(-) AGTAG(C/G)TGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IKZF2 Gene

Variant ID Type Subtype PubMed ID
nsv834528 CNV Loss 17160897
nsv834529 CNV Gain 17160897
nsv517070 CNV Loss 19592680
nsv213831 CNV Loss 16902084
nsv834530 CNV Gain 17160897
dgv4429n71 CNV Loss 21882294
nsv875816 CNV Loss 21882294
nsv470514 CNV Loss 18288195
esv271001 CNV Insertion 20981092
dgv4430n71 CNV Loss 21882294
esv27259 CNV Gain 19812545
nsv3151 CNV Insertion 18451855

Relevant External Links for IKZF2 Gene

HapMap Linkage Disequilibrium report
IKZF2

Disorders for IKZF2 Gene

(2) Novoseek inferred disease relationships for IKZF2 Gene

Disease -log(P) Hits PubMed IDs
leukemia 32.3 8
lymphoma 4.7 4

Relevant External Links for IKZF2

Genetic Association Database (GAD)
IKZF2
Human Genome Epidemiology (HuGE) Navigator
IKZF2
genes like me logo Genes that share disorders with IKZF2: view

No data available for UniProtKB/Swiss-Prot for IKZF2 Gene

Publications for IKZF2 Gene

  1. Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. (PMID: 9512513) Hahm K. … Smale S.T. (Genes Dev. 1998) 2 3 23
  2. Human Helios, an Ikaros-related zinc finger DNA binding protein: cDNA cloning and tissue expression pattern. (PMID: 10541817) Hosokawa Y. … Seto M. (Immunogenetics 1999) 3 4 23
  3. Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PMID: 10978333) Perdomo J. … Crossley M. (J. Biol. Chem. 2000) 3 4 23
  4. Ikaros, Aiolos and Helios: transcription regulators and lymphoid malignancies. (PMID: 12752680) Rebollo A. … Schmitt C. (Immunol. Cell Biol. 2003) 3 23
  5. Characterization of the short isoform of Helios overexpressed in patients with T-cell malignancies. (PMID: 17297655) Tabayashi T. … Tanimoto M. (Cancer Sci. 2007) 3 23

Products for IKZF2 Gene

Sources for IKZF2 Gene

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