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IKZF2 Gene

protein-coding   GIFtS: 53
GCID: GC02M213864

IKAROS Family Zinc Finger 2 (Helios)

(Previous names: zinc finger protein, subfamily 1A, 2 (Helios))
(Previous symbol: ZNFN1A2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
IKAROS Family Zinc Finger 2 (Helios)1 2     ANF1A22 5
ZNFN1A21 2 3     ZNF1A22
HELIOS2 3 5     Zinc Finger DNA Binding Protein Helios2
Zinc Finger Protein, Subfamily 1A, 2 (Helios)1 2     Zinc Finger Protein Helios2
Ikaros Family Zinc Finger Protein 22 3     

External Ids:    HGNC: 131771   Entrez Gene: 228072   Ensembl: ENSG000000304197   OMIM: 6062345   UniProtKB: Q9UKS73   

Export aliases for IKZF2 gene to outside databases

Previous GC identifers: GC02M213579 GC02M205713


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IKZF2 Gene:
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family
(Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of
lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is
thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding
different isoforms have been found for this gene, but the biological validity of some variants has not been
determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for IKZF2 Gene:
IKZF2 (IKAROS family zinc finger 2 (Helios)) is a protein-coding gene. Diseases associated with IKZF2 include hodgkin's lymphoma, and non-hodgkin lymphoma. GO annotations related to this gene include protein heterodimerization activity and protein homodimerization activity. An important paralog of this gene is IKZF4.

UniProtKB/Swiss-Prot: IKZF2_HUMAN, Q9UKS7
Function: Associates with Ikaros at centromeric heterochromatin

Gene Wiki entry for IKZF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IKZF2 gene promoter:
         Pbx1a   Nkx2-5   Tal-1beta   ATF   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIKZF2 promoter sequence
   Search Chromatin IP Primers for IKZF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IKZF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q34   Ensembl cytogenetic band:  2q34   HGNC cytogenetic band: 2q13.1

IKZF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IKZF2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M213864:  view genomic region     (about GC identifiers)

Start:
213,864,408 bp from pter      End:
214,017,151 bp from pter
Size:
152,744 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IKZF2_HUMAN, Q9UKS7 (See protein sequence)
Recommended Name: Zinc finger protein Helios  
Size: 526 amino acids; 59574 Da
Subunit: Interacts with IKZF4 AND IKZF5
Secondary accessions: Q8N6S1
Alternative splicing: 2 isoforms:  Q9UKS7-1   Q9UKS7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IKZF2: NX_Q9UKS7

Explore proteomics data for IKZF2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys283, Lys288
  • Modification sites at PhosphoSitePlus

  • See IKZF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001072994.1  NP_057344.2  

    ENSEMBL proteins: 
     ENSP00000342876   ENSP00000412869   ENSP00000363439   ENSP00000411444   ENSP00000413680  
     ENSP00000389548   ENSP00000363446   ENSP00000396253   ENSP00000406783   ENSP00000402132  
     ENSP00000390045   ENSP00000410447   ENSP00000395203   ENSP00000399574   ENSP00000363447  
     ENSP00000402334  

    IKZF2 Human Recombinant Protein Products:

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    IKZF2 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IKZF: IKAROS zinc fingers
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UKS7

    ProtoNet protein and cluster: Q9UKS7

    UniProtKB/Swiss-Prot: IKZF2_HUMAN, Q9UKS7
    Similarity: Belongs to the Ikaros C2H2-type zinc-finger protein family
    Similarity: Contains 6 C2H2-type zinc fingers


    IKZF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IKZF2_HUMAN, Q9UKS7
    Function: Associates with Ikaros at centromeric heterochromatin

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0042803protein homodimerization activity IEA--
         
    IKZF2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for IKZF2:
     Increased S DNA content  Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ikzf2):
     growth/size/body  hematopoietic system  immune system  mortality/aging  vision/eye 

    IKZF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ikzf2tm1Kast for IKZF2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IKZF2
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    miRNA
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    miRTarBase miRNAs that target IKZF2:
    hsa-mir-130b-5p (MIRT038326)

    Block miRNA regulation of human, mouse, rat IKZF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IKZF2 (see all 186):
    hsa-miR-3938 hsa-miR-520f hsa-miR-128 hsa-miR-342-3p hsa-miR-519a hsa-miR-1273d hsa-miR-208b hsa-miR-4326
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IKZF2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKZF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IKZF2_HUMAN, Q9UKS7: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    IKZF2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including IKZF2: 
              T Helper Cell Differentiation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IKZF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for IKZF2 (Q9UKS71, 3 ENSP000004104474) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC4P565243, ENSP000002646064I2D: score=1 STRING: ENSP00000264606
    IKZF4Q9H2S93, ENSP000002620324I2D: score=1 STRING: ENSP00000262032
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    SIN3BO751823, ENSP000003691314I2D: score=1 STRING: ENSP00000369131
    IKZF1Q134223, ENSP000003316144I2D: score=2 STRING: ENSP00000331614
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0008150biological_process ND--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

    IKZF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IKZF2

    2 Novoseek inferred chemical compound relationships for IKZF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 49.7 10 12153174 (2), 9512513 (1), 14761608 (1), 12752680 (1) (see all 7)
    gold 19.3 1 12443541 (1)



    IKZF2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IKZF2 gene (2 alternative transcripts): 
    NM_001079526.1  NM_016260.2  

    Unigene Cluster for IKZF2:

    IKAROS family zinc finger 2 (Helios)
    Hs.604950  [show with all ESTs]
    Unigene Representative Sequence: NM_001079526
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342002 ENST00000434687 ENST00000484040 ENST00000374319 ENST00000453575
    ENST00000412444 ENST00000439848 ENST00000374326 ENST00000431520 ENST00000433134
    ENST00000452786 ENST00000442445 ENST00000457361(uc002vei.3 uc010fuu.3 uc002vej.3 uc002vek.3 uc010fuv.3 uc002vel.3 uc010fuw.3 uc010fux.3 uc010fuy.3 uc002vem.3 uc002ven.3)
    ENST00000451136 ENST00000421754 ENST00000374327 ENST00000413091
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate IKZF2 (see all 186):
    hsa-miR-3938 hsa-miR-520f hsa-miR-128 hsa-miR-342-3p hsa-miR-519a hsa-miR-1273d hsa-miR-208b hsa-miR-4326
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    GenScript: all cDNA clones in your preferred vector (see all 2): IKZF2 (NM_001079526)
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      QuantiTect SYBR Green Assays in human, mouse, rat IKZF2
      QuantiFast Probe-based Assays in human, mouse, rat IKZF2

    Additional mRNA sequence: 

    AF130863.1 AK301503.1 AL157504.1 AY008294.1 AY587066.1 AY587069.1 AY587070.1 AY587071.1 
    AY587072.1 BC028936.1 

    5 DOTS entries:

    DT.92068539  DT.99940172  DT.102831203  DT.102831199  DT.102831200 

    Selected AceView cDNA sequences (see all 28):

    BG393422 BX447320 BC028936 AY587067 AY587065 BM986995 AY587062 AY587064 
    BG613733 NM_016260 AY587063 AY587069 AF130863 AI420325 AY587068 AY587066 
    AY587072 AY587073 AY008294 AY587071 BX279947 AY587070 BE175677 BG258609 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IKZF2 (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ·
    SP1:                                                                          -                       -                 -     -     -                           
    SP2:                                                              -     -     -                       -                             -                           
    SP3:              -     -                 -                       -     -     -                 -     -                 -     -     -                           
    SP4:                                                              -                                   -                 -     -     -                           
    SP5:                                -     -                       -     -     -                       -                 -     -     -                           

    ExUns: 16d
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for IKZF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IKZF2 expression in normal human tissues (normalized intensities)      IKZF2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGAGTGTG
    IKZF2 Expression
    About this image


    IKZF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
     
     Endothelium (Cardiovascular System)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Liver Bud
    IKZF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IKZF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.604950
        Pathway & Disease-focused RT2 Profiler PCR Array including IKZF2: 
              T Helper Cell Differentiation in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKZF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IKZF2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ikzf21 , 5 IKAROS family zinc finger 21, 5 95.75(n)1
    97.91(a)1
      1 (34.90 cM)5
    227791  NM_011770.41  NP_035900.21 
     695312145 
    chicken
    (Gallus gallus)
    Aves IKZF21 IKAROS family zinc finger 2 (Helios) 87.9(n)
    89.16(a)
      395309  NM_204607.1  NP_989938.1 
    lizard
    (Anolis carolinensis)
    Reptilia IKZF26
    IKAROS family zinc finger 2 (Helios)
    86(a)
    1 ↔ 1
    1(115366428-115539415)
    African clawed frog
    (Xenopus laevis)
    Amphibia znfn1a1-A-prov2 ikaros-related transcription factor 77.72(n)    AF024439.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:zfos-1425h8.11 si:zfos-1425h8.1 62.04(n)
    57.56(a)
      100150224  NM_001161762.1  NP_001155234.1 


    ENSEMBL Gene Tree for IKZF2 (if available)
    TreeFam Gene Tree for IKZF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IKZF2 gene
    IKZF42  IKZF52  IKZF12  IKZF32  
    Selected SIMAP similar genes for IKZF2 using alignment to 10 protein entries:     IKZF2_HUMAN (see all proteins) (see all similar genes):
    ZNFN1A2    ZNF516    ZNF55    ZNF253    ZNF66    ZNF841
    ZNF876P    kr-znf3    IKZF3    IKZF4    ZNF85    ZFS-5
    ZNF232    ZNF850    IKZF1    ZSCAN21    zf30    A-328A3.4

    IKZF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IKZF2 (see all 2822)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483538821,2
    C--213405267(+) GCGGCC/TCCATT 1 -- us2k10--------
    rs1828957661,2
    --213405306(+) CTGAAG/TCGGGA 1 -- us2k10--------
    rs102096751,2
    C,F,A,H--213405320(+) GAGGGA/GTCCTG 1 -- us2k110Minor allele frequency- G:0.41WA NA CSA EA 371
    rs19227911,2
    C,F,A,H--213406603(-) ACATTC/GTGTAA 1 -- us2k113Minor allele frequency- G:0.39NA WA CSA EA 377
    rs126172171,2
    C,F,A,H--213863944(+) TCTAAA/GAAATA 2 -- ds500113Minor allele frequency- G:0.48NS EA WA NA 786
    rs562962921,2
    C--213863970(+) TAGTGT/-TATTC 2 -- ds50011Minor allele frequency- -:0.00NA 2
    rs1381287161,2
    --213864014(+) ACCTCC/TTGTGT 2 -- ds50010--------
    rs126172511,2
    C,F,A,H--213864027(+) TTTAAG/TTGCAC 2 -- ds500120Minor allele frequency- T:0.47NS EA WA NA 2242
    rs126172741,2
    C,F,A,H--213864091(+) ATATAA/GAAAGG 2 -- ds500112Minor allele frequency- G:0.49NS EA WA NA 784
    rs134305351,2
    C,F,H--213864129(+) TTTTAA/TAAGTG 2 -- ds50016Minor allele frequency- T:0.06NS EA CSA WA 509

    HapMap Linkage Disequilibrium report for IKZF2 (213864408 - 214017151 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IKZF2 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv271001CNV Insertion20981092
    nsv3151CNV Insertion18451855
    nsv470514CNV Loss18288195
    nsv517070CNV Loss19592680
    dgv4430n71CNV Loss21882294
    nsv875816CNV Loss21882294
    nsv213831CNV Loss16902084
    dgv4429n71CNV Loss21882294
    nsv834528CNV Loss17160897
    nsv834529CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IKZF2
    DNA2.0 Custom Variant and Variant Library Synthesis for IKZF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606234    OMIM disorders: --

    10 diseases for IKZF2:    About MalaCards
    hodgkin's lymphoma    non-hodgkin lymphoma    lymphoblastic leukemia    myocardial infarction
    asthma    renal cell carcinoma    leukemia    prostate cancer
    neuronitis    prostatitis


    IKZF2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for IKZF2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 32.3 9 12153174 (4), 20432734 (2), 12028018 (1), 12752680 (1)
    lymphoma 4.7 4 12648068 (3), 17297655 (1)

    Genetic Association Database (GAD): IKZF2
    Human Genome Epidemiology (HuGE) Navigator: IKZF2 (5 documents)

    Export disorders for IKZF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IKZF2 gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with IKZF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. (PubMed id 9512513)1, 3, 9 Hahm K....Smale S.T. (amp 1998)
    2. Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PubMed id 10978333)1, 2, 9 Perdomo J.... Crossley M. (J. Biol. Chem. 2000)
    3. Human Helios, an Ikaros-related zinc finger DNA binding protein: cDNA cloning and tissue expression pattern. (PubMed id 10541817)1, 2, 9 Hosokawa Y.... Seto M. (Immunogenetics 1999)
    4. Genetic evidence for a role of IL33 in nasal polyposis. (PubMed id 19860791)1, 4 Buysschaert I.D....Lambrechts D. (Allergy 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. (PubMed id 19198610)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. (PubMed id 9560339)1, 3 Kelley C.M....Morgan B.A. (Curr. Biol. 1998)
    9. Expression of a unique helios isoform in human leukemia cells. (PubMed id 12153174)1, 9 Sun L....Uckun F.M. (amp 2002)
    10. A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells. (PubMed id 20226531)1, 9 Getnet D....Drake C.G. (Mol. Immunol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22807 HGNC: 13177 AceView: ZNFN1A2 Ensembl:ENSG00000030419 euGenes: HUgn22807
    ECgene: IKZF2 H-InvDB: IKZF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IKZF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IKZF2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IKZF2 gene:
    Search GeneIP for patents involving IKZF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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