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IKBKG Gene

protein-coding   GIFtS: 70
GCID: GC0XP153769

Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells,...

(Previous name: incontinentia pigmenti)
(Previous symbols: IP2, IP1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase
Gamma1 2
     IKKG2 3
IP21 2 5     I-Kappa-B Kinase Subunit Gamma2 3
FIP32 3 5     NF-Kappa-B Essential Modifier2 3
NEMO2 3 5     AMCBX12 5
IP11 2     IPD22 5
Incontinentia Pigmenti1 2     Fip3p2
IkB Kinase Subunit Gamma2 3     IP2
IkB Kinase-Associated Protein 12 3     ZC2HC92
Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Gamma2 3     IkB Kinase Gamma Subunit2
FIP-32 3     NF-Kappa-B Essential Modulator2
IKK-gamma2 3     NFkappaB Essential Modulator2
IKKAP12 3     

External Ids:    HGNC: 59611   Entrez Gene: 85172   Ensembl: ENSG000000730097   OMIM: 3002485   UniProtKB: Q9Y6K93   

Export aliases for IKBKG gene to outside databases

Previous GC identifers: GC0XM147930 GC0XP150151 GC0XP151354 GC0XP152238 GC0XP152243 GC0XP153334 GC0XP153423 GC0XP142347


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IKBKG Gene:
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates
NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways.
Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other
types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this
gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. (provided
by RefSeq, Aug 2011)

GeneCards Summary for IKBKG Gene:
IKBKG (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma) is a protein-coding gene. Diseases associated with IKBKG include bloch-sulzberger syndrome, and invasive pneumococcal disease, recurrent isolated, 2. GO annotations related to this gene include protein homodimerization activity and signal transducer activity. An important paralog of this gene is OPTN.

UniProtKB/Swiss-Prot: NEMO_HUMAN, Q9Y6K9
Function: Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to
the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding
to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways.
However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear
polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX
activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential
for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function
requires 'Lys-27'-linked polyubiquitination

Gene Wiki entry for IKBKG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011681.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IKBKG gene promoter:
         p53   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): IKBKG promoter sequence
   Search Chromatin IP Primers for IKBKG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IKBKG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

IKBKG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IKBKG gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP153769:  view genomic region     (about GC identifiers)

Start:
153,769,414 bp from pter      End:
153,796,782 bp from pter
Size:
27,369 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NEMO_HUMAN, Q9Y6K9 (See protein sequence)
Recommended Name: NF-kappa-B essential modulator  
Size: 419 amino acids; 48198 Da
Subunit: Homodimer; disulfide-linked. Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK,
IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The
IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex.
The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65. Part
of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Interacts with COPS3, CYLD, NALP2,
TRPC4AP and LRDD. Interacts with ATM; the complex is exported from the nucleus. Interacts with TRAF6. Interacts
with HTLV-1 Tax oncoprotein; the interaction activates IKBKG. Interacts with IKBKE. Interacts with TANK; the
interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK, IKBKB and IKBKG.
Interacts with ZFAND5. Interacts with RIPK2. Interacts with TNIP1 and TNFAIP3; TNIP1 facilitates the
TNFAIP3-mediated de-ubiquitination of IKBKG. Interacts with TNFAIP3; the interaction is induced by TNF
stimulation and by polyubiquitin. Binds polyubiquitin; the interaction is mediated by two domains; reports about
the binding to 'Lys-63'-linked and/or linear polyubiquitin, respective binding affinities and stoichiometry are
conflicting. Interacts with Shigella flexneri ipah9.8; the interaction promotes TNIP1-dependent 'Lys-27'-linked
polyubiquitination of IKBKG which perturbs NF-kappa-B activation during bacterial infection. Interacts with
NLRP10
6 PDB 3D structures from and Proteopedia for IKBKG:
2JVX (3D)        2JVY (3D)        3BRT (3D)        3BRV (3D)        3CL3 (3D)        3FX0 (3D)    
Secondary accessions: Q7LBY6 Q7Z7F1
Alternative splicing: 3 isoforms:  Q9Y6K9-1   Q9Y6K9-2   Q9Y6K9-3   

Explore the universe of human proteins at neXtProt for IKBKG: NX_Q9Y6K9

Explore proteomics data for IKBKG at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-68 attenuates aminoterminal homodimerization1
  • Polyubiquitinated on Lys-285 through 'Lys-63'; the ubiquitination is mediated by NOD2 and RIPK2 and probably plays
    a role in signaling by facilitating interactions with ubiquitin domain-containing proteins and activates the
    NF-kappa-B pathway. Polyubiquitinated on Lys-399 through 'Lys-63'; the ubiquitination is mediated by BCL10, MALT1
    and TRAF6 and probably plays a role in signaling by facilitating interactions with ubiquitin domain-containing
    proteins and activates the NF-kappa-B pathway. Monoubiquitinated on Lys-277 and Lys-309; promotes nuclear export.
    Polyubiquitinated through 'Lys-27' by TRIM23; involved in antiviral innate and inflammatory responses. Linear
    polyubiquitinated on Lys-111, Lys-143, Lys-226, Lys-246, Lys-264, Lys-277, Lys-285, Lys-292, Lys-302, Lys-309 and
    Lys-326; the head-to-tail polyubiquitination is mediated by the LUBAC complex and plays a key role in NF-kappa-B
    activation. Polyubiquitinated on Lys-309 and Lys-321 via 'Lys-27'-linked ubiquitin by Shigella flexneri E3
    ubiquitin-protein ligase ipah9.8, leading to its degradation by the proteasome1
  • Sumoylated on Lys-277 and Lys-309 with SUMO1; the modification results in phosphorylation of Ser-85 by ATM leading
    to a replacement of the sumoylation by mono-ubiquitination on these residues1
  • Neddylated by TRIM40, resulting in stabilization of NFKBIA and down-regulation of NF-kappa-B activity1
  • Ubiquitination2 at Lys111, Lys139, Lys143, Lys226, Lys246, Lys264, Lys283, Lys285, Lys292, Lys302,
                                 Lys321, Lys325, Lys326, Lys399
  • Modification sites at PhosphoSitePlus

  • See IKBKG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001093326.2  NP_001093327.1  NP_001138727.1  NP_003630.1  

    ENSEMBL proteins: 
     ENSP00000394934   ENSP00000390368   ENSP00000358622   ENSP00000358620   ENSP00000395205  
     ENSP00000358619   ENSP00000398579   ENSP00000263518   ENSP00000420565   ENSP00000377180  
     ENSP00000400769   ENSP00000358615   ENSP00000401308   ENSP00000358614  
    Reactome Protein details: Q9Y6K9

    IKBKG Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for IKBKG
    OriGene Protein Over-expression Lysate for IKBKG
    OriGene MassSpec for IKBKG
    OriGene Custom Protein Services for IKBKG
    GenScript Custom Purified and Recombinant Proteins Services for IKBKG
    Novus Biologicals IKBKG Proteins
    Novus Biologicals IKBKG Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    IKBKG Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IKBKG
    R&D Systems Antibodies for IKBKG (IKK gamma)
    Cell Signaling Technology (CST) Antibodies for IKBKG  (IKK-gamma)
    OriGene Antibodies for IKBKG
    OriGene Custom Antibody Services for IKBKG
    Novus Biologicals IKBKG Antibodies
    Abcam antibodies for IKBKG
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for IKBKG
    LSBio Antibodies in human, mouse, rat for IKBKG

    IKBKG Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IKBKG
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IKBKG
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZC2HC: Zinc fingers, C2HC-type containing

    1 InterPro protein domain:
     IPR021063 NEMO_N

    Graphical View of Domain Structure for InterPro Entry Q9Y6K9

    ProtoNet protein and cluster: Q9Y6K9

    UniProtKB/Swiss-Prot: NEMO_HUMAN, Q9Y6K9
    Domain: The leucine-zipper domain and the C2HC-type zinc-finger are essential for polyubiquitin binding and for
    the activation of IRF3
    Similarity: Contains 1 C2HC-type zinc finger


    IKBKG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEMO_HUMAN, Q9Y6K9
    Function: Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to
    the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding
    to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways.
    However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear
    polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX
    activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential
    for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function
    requires 'Lys-27'-linked polyubiquitination

         Genatlas biochemistry entry for IKBKG:
    inhibitor of kappa light polypeptide enhancer in B cells,kinase gamma,complexing with IKBKA and IKBKB,associating
    preferentially with IKBKB,required for the activation of the complex

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS9927690
    GO:0005515protein binding IPI11113112
    GO:0019904protein domain specific binding IPI15341735
    GO:0042803protein homodimerization activity IDA--
    GO:0046872metal ion binding IEA--
         
    IKBKG for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for IKBKG:
     Decreased p24 protein expressi  Downregulation of NF-kappaB pa  Increased HPV18 LCR reporter a 

         Selected MGI mutant phenotypes (inferred from 8 alleles(MGI details for Ikbkg) (see all 17):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  normal  pigmentation 

    IKBKG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IKBKG: Ikbkgtm1Mka Ikbkgtm1Mpa Ikbkgtm1Mak

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IKBKG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IKBKG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IKBKG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IKBKG

    miRNA
    Products:
        
    miRTarBase miRNAs that target IKBKG:
    hsa-mir-15a-5p (MIRT051313)

    Block miRNA regulation of human, mouse, rat IKBKG using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate IKBKG
    SwitchGear 3'UTR luciferase reporter plasmidIKBKG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IKBKG
    Predesigned siRNA for gene silencing in human, mouse, rat IKBKG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IKBKG

    Clone
    Products:
         
    OriGene clones in human, mouse for IKBKG (see all 25)
    OriGene ORF clones in mouse, rat for IKBKG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): IKBKG (NM_001099857)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IKBKG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKBKG

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IKBKG
    Browse ESI BIO Cell Lines and PureStem Progenitors for IKBKG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKBKG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NEMO_HUMAN, Q9Y6K9: Cytoplasm. Nucleus. Note=Sumoylated NEMO accumulates in the nucleus in response to genotoxic
    stress
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005634nucleus IDA14651848
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0008385colocalizes with IkappaB kinase complex TAS16831874

    IKBKG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IKBKG About   (see all 92)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1RANK Signaling in Osteoclasts
    BAFF in B-Cell Signaling0.92
    Apoptosis and survival APRIL and BAFF signaling0.39
    APRIL Pathway0.92
    RANK Pathway0.38
    RANK Signaling in Osteoclasts0.45
    RANKL/RANK Signaling Pathway0.31
    2Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.68
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.68
    NOD pathway0.33
    3B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    T cell receptor signaling pathway0.38
    BCR signaling pathway0.42
    TCR Signaling Pathway0.36
    4IL-17 Family Signaling Pathways
    IL-17 Family Signaling Pathways0.51
    Mucin expression in CF via IL 6, IL 17 signaling pathways0.48
    IL17 signaling pathway0.51
    5TWEAK Pathway
    TWEAK Pathway0.87
    GITR Pathway0.46
    DR3 Signaling0.87
    Apoptotic Pathways Triggered By HIV10.42
    TNFR1 Pathway0.56
    Apoptosis through Death Receptors0.42
    TNF Signaling0.55
    TRAIL Pathway0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for IKBKG (see all 7)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-1 Family Signaling Pathways
    IL-17 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IKBKG (see all 62)
        TWEAK Pathway
    14-3-3 Induced Apoptosis
    LT-BetaR Pathway
    Toll-Like Receptors Pathway
    Antioxidant Action of Vitamin-C

    1 Cell Signaling Technology (CST) Pathway for IKBKG
        NF-kappaB Signaling

    5 Tocris Bioscience Pathways for IKBKG
        Akt Pathway
    Insulin Pathway
    Apoptosis Pathway
    Toll-like Receptor Pathway
    NF-kappaB Pathway

    Selected GeneGo (Thomson Reuters) Pathways for IKBKG (see all 22)
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Immune response Bacterial infections in normal airways
    Immune response CD28 signaling
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    Selected BioSystems Pathways for IKBKG (see all 24)
        MAPK signaling pathway
    Apoptosis
    NOD pathway
    MicroRNAs in cardiomyocyte hypertrophy
    EBV LMP1 signaling

    Selected Reactome Pathways for IKBKG (see all 14)
        NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
    JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
    IRAK1 recruits IKK complex
    IKK complex recruitment mediated by RIP1
    FCERI mediated NF-kB activation


    Selected Kegg Pathways  (Kegg details for IKBKG) (see all 32):
        MAPK signaling pathway
    Ras signaling pathway
    Chemokine signaling pathway
    NF-kappa B signaling pathway
    PI3K-Akt signaling pathway


    IKBKG for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IKBKG: 
              TNF Ligands & Receptors in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Apoptosis 384HT in human mouse rat
              Necrosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IKBKG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IKBKG (Q9Y6K91, 2, 3 ENSP000003586224) via UniProtKB, MINT, STRING, and/or I2D (see all 511)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000228321P013751, 2, 3, ENSP000003928584EBI-81279,EBI-359977 MINT-8410390 I2D: score=1 STRING: ENSP00000392858
    HSPA1AP081073, ENSP000003648024I2D: score=4 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=4 
    ENSG00000215328P081073I2D: score=4 
    ENSG00000224501P081073I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS--
    GO:0001782B cell homeostasis IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    IKBKG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IKBKG (NEMO)

    10 Novoseek inferred chemical compound relationships for IKBKG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 39 26 14764716 (4), 18313693 (2), 16794254 (2), 18207244 (2) (see all 12)
    geldanamycin 32.1 1 16432176 (1)
    leucine 31.5 7 15107419 (1), 18080803 (1), 10906125 (1), 11080796 (1)
    cytidine 18.7 2 14610488 (1)
    serine 4.26 3 12419799 (1), 16611882 (1), 12657630 (1)
    glucose 3.21 1 16754954 (1)
    calcium 2.78 4 17074802 (2)
    lipid 0 12 19129196 (1), 12496421 (1)
    tyrosine 0 1 16379012 (1)
    arginine 0 2 14764716 (1), 18347055 (1)

    4 PharmGKB related drug/compound annotations for IKBKG gene    About this table
    Drug/compound PharmGKB Annotation
    artesunateCA  
    primaquineCA  
    pyrimethamineCA  
    sulfadoxineCA  



    IKBKG for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for IKBKG gene (4 alternative transcripts): 
    NM_001099856.3  NM_001099857.2  NM_001145255.2  NM_003639.4  

    Unigene Cluster for IKBKG:

    Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
    Hs.43505  [show with all ESTs]
    Unigene Representative Sequence: NM_001099857
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000440286 ENST00000422680 ENST00000369609(uc011mzr.2) ENST00000369607
    ENST00000445622 ENST00000369606(uc010nva.3 uc004fmb.4 uc011mzs.2)
    ENST00000413620 ENST00000263518(uc022cii.1 uc010nvc.1 uc010nvd.1)
    ENST00000470142 ENST00000393549 ENST00000455588 ENST00000369602 ENST00000424839
    ENST00000369601(uc004fmd.3) ENST00000490409 ENST00000492469 ENST00000479063

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF062089.1 AF074382.1 AF091453.1 AF261086.1 AK000593.1 AK308366.1 AY114157.1 AY429546.1 
    AY429547.1 AY429548.1 BC000299.2 BC012114.1 BC046922.1 BC050612.2 BT019621.1 

    21 DOTS entries:

    DT.312097  DT.95289662  DT.121294375  DT.121293894  DT.95289591  DT.100815410  DT.91746867  DT.97817906 
    DT.121294248  DT.100815417  DT.91737686  DT.95149808  DT.100737461  DT.91650957  DT.91746868  DT.100815406 
    DT.100815413  DT.100815416  DT.121293666  DT.121294438  DT.97852905 

    Selected AceView cDNA sequences (see all 250):

    CD370907 BI836535 BM740078 AW007016 AY429546 CR612085 AW247584 BE391247 
    BM759242 BQ943841 BM820769 BM831774 CR604149 AY429548 AK000593 AI985232 
    BC046922 BM716314 BI770383 BU616100 BQ439256 AI935015 AY429547 CD366604 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IKBKG (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13
    SP1:              -     -     -     -                                         -                           
    SP2:                                -                                         -                           
    SP3:                                -                                         -                           
    SP4:                                                                          -                           
    SP5:                                -                             -           -     -     -               


    ECgene alternative splicing isoforms for IKBKG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    IKBKG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTATTCCATT
    IKBKG Expression
    About this image


    IKBKG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    IKBKG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IKBKG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.43505

    UniProtKB/Swiss-Prot: NEMO_HUMAN, Q9Y6K9
    Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IKBKG: 
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              Necrosis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IKBKG gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ikbkg1 , 5 inhibitor of kappaB kinase gamma1, 5 84.25(n)1
    87.35(a)1
      X (38.00 cM)5
    161511  NM_001161422.11  NP_001154894.11 
     743932905 
    lizard
    (Anolis carolinensis)
    Reptilia IKBKG6
    inhibitor of kappa light polypeptide gene enhancer...
    62(a)
    1 ↔ 1
    2(89756946-89775442)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ikbkg1 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma less 60.55(n)
    52.51(a)
      100145270  NM_001126749.1  NP_001120221.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ikbkg1 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma less 54.93(n)
    48.66(a)
      541530  NM_001014344.2  NP_001014366.1 


    ENSEMBL Gene Tree for IKBKG (if available)
    TreeFam Gene Tree for IKBKG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IKBKG gene
    OPTN2  

    IKBKG for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for IKBKG
    PGOHUM00000241614 PGOHUM00000241615


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IKBKG (see all 254)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1486959641,2,,4
    C,FIncontinentia pigmenti (IP)4 untested1153648868(+) TGGAGG/AAGAAT 8 /K /E mis11Minor allele frequency- A:0.00NA 4398
    rs1793638661,2,,4
    CRecurrent isolated invasive pneumococcal disease 2 (IPD2)4 pathogenic1153655346(+) AGGGTC/GGGTGA 8 R G mis10--------
    rs1378533261,2,,4
    CImmunodeficiency, NEMO-related, without anhidrotic ectodermal dysplasia (NEMOID)4 pathogenic1153661149(+) GGAGTA/G/TCATTG 12 Y C F mis10--------
    VAR_0319604
    X-linked familial atypical micobacteriosis 1 (AMCBX1)4--see VAR_0319602 R Q mis40--------
    VAR_0113244
    Ectodermal dysplasia, anhidrotic, with immunodeficiency X-linked (EDAID)4--see VAR_0113242 D V mis40--------
    VAR_0113224
    Ectodermal dysplasia, anhidrotic, with immunodeficiency X-linked (EDAID)4--see VAR_0113222 A G mis40--------
    VAR_0091824
    Incontinentia pigmenti (IP)4--see VAR_0091822 M V mis40--------
    VAR_0319594
    X-linked familial atypical micobacteriosis 1 (AMCBX1)4--see VAR_0319592 E A mis40--------
    VAR_0113264
    Ectodermal dysplasia, anhidrotic, with immunodeficiency X-linked (EDAID)4--see VAR_0113262 C R mis40--------
    VAR_0264954
    Ectodermal dysplasia, anhidrotic, with immunodeficiency X-linked (EDAID)4--see VAR_0264952 L R mis40--------

    HapMap Linkage Disequilibrium report for IKBKG (153769414 - 153796782 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for IKBKG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508816CNV Insertion20534489
    esv24652CNV Gain19812545
    nsv519042CNV Gain19592680
    esv33199CNV Gain+Loss17666407
    esv33784CNV Gain+Loss17666407
    esv27496CNV Gain+Loss19812545

    Human Gene Mutation Database (HGMD): IKBKG
    Locus Specific Mutation Databases (LSDB): IKBKG

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300248   
    OMIM disorders: 308300  300291  300301  300584  300636  300640  
    UniProtKB/Swiss-Prot: NEMO_HUMAN, Q9Y6K9
  • Ectodermal dysplasia, anhidrotic, with immunodeficiency X-linked (EDAID) [MIM:300291]: A form of
    ectoderma dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal
    structures. Characterized by absence of sweat glands, sparse scalp hair, rare conical teeth and immunological
    abnormalities resulting in severe infectious diseases. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis and lymphedema (OLEDAID)
    [MIM:300301]: A form of ectoderma dysplasia, a heterogeneous group of disorders due to abnormal development of
    two or more ectodermal structures. Characterized by the association of anhidrotic ectodermal dysplasia with
    severe immunodeficiency, osteopetrosis and lymphedema. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Immunodeficiency, NEMO-related, without anhidrotic ectodermal dysplasia (NEMOID) [MIM:300584]: Patients
    manifest immunodeficiency not associated with other abnormalities, and resulting in increased susceptibility to
    infections. Patients suffer from multiple episodes of infectious diseases. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • X-linked familial atypical micobacteriosis 1 (AMCBX1) [MIM:300636]: X-linked recessive form of Mendelian
    susceptibility to mycobacterial disease (MSMD). MSMD is a congenital syndrome resulting in predisposition to
    clinical disease caused by weakly virulent mycobacterial species, such as bacillus Calmette-Guerin vaccines and
    non-tuberculous, environmental mycobacteria. Patients are also susceptible to the more virulent species
    Mycobacterium tuberculosis. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry
  • Recurrent isolated invasive pneumococcal disease 2 (IPD2) [MIM:300640]: Recurrent invasive pneumococcal
    disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or
    different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the
    most important known risk factor for subsequent IPD. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Incontinentia pigmenti (IP) [MIM:308300]: A genodermatosis usually prenatally lethal in males. In
    affected females, it causes abnormalities of the skin, hair, eyes, nails, teeth, skeleton, heart, and central
    nervous system. The prominent skin signs occur in four classic cutaneous stages: perinatal inflammatory vesicles,
    verrucous patches, a distinctive pattern of hyperpigmentation and dermal scarring. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • Selected diseases for IKBKG (see all 73):    
    About MalaCards
    bloch-sulzberger syndrome    invasive pneumococcal disease, recurrent isolated, 2    linear and whorled nevoid hypermelanosis    hypohidrotic ectodermal dysplasia with immune deficiency
    familial atypical mycobacteriosis, x-linked 1    ectodermal, dysplasia, anhidrotic, lymphedema and immunodeficiency    immunodeficiency without anhidrotic ectodermal dysplasia    incontinentia pigmenti achromians
    anodontia    hypohidrotic ectodermal dysplasia    congenital syphilis    atypical mycobacteriosis, familial
    syphilis    aicardi syndrome    ectodermal dysplasia    focal dermal hypoplasia
    cerebral aneurysms    lymphedema    epidermal nevus    exudative vitreoretinopathy

    9 diseases from the University of Copenhagen DISEASES database for IKBKG:
    Skin disease     Focal dermal hypoplasia     Hypohidrotic ectodermal dysplasia     Retinal detachment
    Retinopathy of prematurity     Coats disease     Alopecia     Exudative vitreoretinopathy
    Microphthalmia

    IKBKG for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for IKBKG gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    incontinentia pigmenti 95.4 45 20434027 (5), 18841575 (2), 15833158 (2), 16399796 (2) (see all 30)
    ectodermal dysplasia, hypohidrotic 85.3 14 16379012 (2), 12651765 (1), 16228229 (1), 18313693 (1) (see all 11)
    ectodermal dysplasia 80.8 10 16794254 (2), 14764716 (1), 18350553 (1), 20133626 (1) (see all 8)
    leukemia t-cell 67.8 5 12435599 (2), 10364167 (1), 16611882 (1), 10438454 (1)
    necrosis 50.8 19 17000764 (2), 12867425 (2), 12244103 (1), 17047224 (1) (see all 12)
    hyperpigmentation 43.8 1 20434027 (1)
    immunodeficiency 38.3 28 15577852 (4), 16228229 (2), 12657630 (2), 16333836 (2) (see all 16)
    osteopetrosis 32 2 11242109 (1), 12351572 (1)
    tumors 31.8 18 17000764 (2), 12867425 (2), 12244103 (1), 17047224 (1) (see all 11)
    skin lesion 31.5 2 16399796 (2)

    GeneTests: IKBKG
    GeneReviews: IKBKG
    Genetic Association Database (GAD): IKBKG
    Human Genome Epidemiology (HuGE) Navigator: IKBKG (6 documents)

    Export disorders for IKBKG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IKBKG gene, integrated from 10 sources (see all 456):
    (articles sorted by number of sources associating them with IKBKG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A recurrent deletion in the ubiquitously expressed NEMO (IKK-gamma) gene accounts for the vast majority of incontinentia pigmenti mutations. (PubMed id 11590134)1, 2, 3, 9 Aradhya S.... Nelson D.L. (Hum. Mol. Genet. 2001)
    2. Isolation of full-length cDNA and chromosomal localization of human NF-kappaB modulator NEMO to Xq28. (PubMed id 10087442)1, 2, 3 Jin D.-Y. and Jeang K.-T. (J. Biomed. Sci. 1999)
    3. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. (PubMed id 9751060)1, 2, 3 Rothwarf D.M.... Karin M. (Nature 1998)
    4. Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation. (PubMed id 12612076)1, 2, 9 Tegethoff S.... Scheidereit C. (Mol. Cell. Biol. 2003)
    5. Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation. (PubMed id 16547522)1, 2, 9 Wu C.J.... Ashwell J.D. (Nat. Cell Biol. 2006)
    6. A novel X-linked disorder of immune deficiency and hypohidrotic ectodermal dysplasia is allelic to incontinentia pigmenti and due to mutations in IKK-gamma (NEMO). (PubMed id 11047757)1, 2, 9 Zonana J.... Ferguson B.M. (Am. J. Hum. Genet. 2000)
    7. Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation. (PubMed id 18313693)1, 2, 9 Cordier F.... Agou F. (J. Mol. Biol. 2008)
    8. X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappa B signaling. (PubMed id 11242109)1, 2, 9 Doeffinger R.... Casanova J.-L. (Nat. Genet. 2001)
    9. Molecular analysis of the genetic defect in a large cohort of IP patients and identification of novel NEMO mutations interfering with NF-kappaB activation. (PubMed id 15229184)1, 2, 9 Fusco F.... Ursini M.V. (Hum. Mol. Genet. 2004)
    10. In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase. (PubMed id 12657630)1, 2, 9 Carter R.S.... Ballard D.W. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8517 HGNC: 5961 AceView: IKBKG Ensembl:ENSG00000073009 euGenes: HUgn8517
    ECgene: IKBKG Kegg: 8517 H-InvDB: IKBKG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IKBKG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IKBKG Genetics and Cytogenetics in Oncology and Haematology
    IKBKGbasehttp://bioinf.uta.fi/IKBKGbase/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=IKBKG[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IKBKG gene:
    Search GeneIP for patents involving IKBKG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Custom Antibody / Protein Production Service
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     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for IKBKG
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKBKG
     SwitchGear 3'UTR luciferase reporter plasmids for IKBKG
     SwitchGear Promoter luciferase reporter plasmids for IKBKG
     ThermoFisher Antibody for IKBKG
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKBKG
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IKBKG
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IKBKG
     LSBio Antibodies in human, mouse, rat for IKBKG
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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