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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IKBKE Gene

protein-coding   GIFtS: 62
GCID: GC01P206643

inhibitor of kappa light polypeptide gene enhancer in B-cells,...
 Explore 28 diseases affiliated with
IKBKE via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IKBKE    

Aliases
for IKBKE gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase
Epsilon1 2
     I-Kappa-B Kinase Epsilon2 3
IKK-I1     IKK-Related Kinase Epsilon2
IKKE1 2 3     Inducible IkappaB Kinase2
KIAA01511 3     Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Epsilon2
Inducible I Kappa-B Kinase2 3     EC 2.7.11.103
IKK-E2 3     IkBKE3
IKK-Epsilon1     EC 2.7.118
IKKI2 3     

External Ids:    HGNC: 145521   Entrez Gene: 96412   Ensembl: ENSG000001434667   OMIM: 6050485   UniProtKB: Q141643   

Export aliases for IKBKE gene to outside databases

Previous GC identifers: GC01P202354 GC01P203287 GC01P203727 GC01P203032 GC01P204710 GC01P177341


Summaries
for IKBKE gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IKBKE:
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling
pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed
in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 (PubMed 19481526)).(supplied by
OMIM, Oct 2009)

UniProtKB/Swiss-Prot: IKKE_HUMAN, Q14164
Function: Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex
and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells
against DNA damage-induced cell death

Gene Wiki entry for IKBKE


Genomic Views
for IKBKE gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IKBKE gene promoter:
         COUP-TF1   C/EBPbeta   COUP   HNF-4alpha2   HNF-4alpha1   C/EBPalpha   RORalpha1   CHOP-10   COUP-TF   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IKBKE promoter sequence
   Search SABiosciences Chromatin IP Primers for IKBKE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IKBKE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q31

IKBKE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IKBKE gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P206643:  view genomic region     (about GC identifiers)

Start:
 206,643,586 bp from pter      End:
 206,670,223 bp from pter
Size:
 26,638 bases      Orientation:
 plus strand

Proteins
for IKBKE gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IKKE_HUMAN, Q14164 (See protein sequence)
Recommended Name: Inhibitor of nuclear factor kappa-B kinase subunit epsilon  
Size: 716 amino acids; 80462 Da
Subunit: May interact with MAVS/IPS1. Interacts with AZI2. Interacts with SIKE1. Interacts with TICAM1/TRIF, IRF3 and
DDX58/RIG-I, interactions are disrupted by the interaction between IKBKE and SIKE1. Interacts with TOPORS; induced by
DNA damage. Interacts with CYLD
Subcellular location: Cytoplasm. Nucleus. Nucleus, PML body. Note=Targeting to PML nuclear bodies upon DNA damage is
TOPORS-dependent
Sequence caution: Sequence=BAA09772.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D3DT78 Q3B754 Q3KR43 Q5JTS6
Alternative splicing: 2 isoforms:  Q14164-1   Q14164-2   

Explore the universe of human proteins at neXtProt for IKBKE: NX_Q14164

Post-translational modifications:

  • Autophosphorylated and phosphorylated by IKBKB/IKKB1
  • Sumoylation by TOPORS upon DNA damage is required for protection of cells against DNA damage-induced cell death.
    • Desumoylated by SENP11
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14164

    • 4/5 DME Specific Peptides for IKBKE (Q14164) (see all 5)
     GPRRNKE  HRDIKPGN  YNEEQIHK  YHAATGSLPF 

    IKBKE Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001180250.1  NP_001180251.1  NP_054721.1  

    ENSEMBL proteins: 
     ENSP00000356087   ENSP00000444529  
    Reactome Protein details: Q14164
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant IKBKE Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: IKBKE
    OriGene Protein Over-expression Lysate: IKBKE
    OriGene Custom Protein Services for IKBKE 
    GenScript Custom Purified and Recombinant Proteins Services for IKBKE
    Novus Biologicals IKBKE Proteins
    Novus Biologicals IKBKE Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane ----


    IKBKE for ontologies           About GeneDecksing



    IKBKE Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IKBKE
    R&D Systems Antibodies for IKBKE (IKK epsilon)
    Cell Signaling Technology (CST) Antibodies for IKBKE  (IKK-epsilon)
    OriGene Antibodies (see all 2): IKBKE
    OriGene Custom Antibody Services for IKBKE 
    GenScript Custom Superior Antibodies Services for IKBKE
    Novus Biologicals IKBKE Antibodies
    Abcam antibodies for IKBKE 
    Browse Antibodies at Uscn
    ThermoFisher Antibody for IKBKE

    Assay Products for IKBKE: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IKBKE
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for IKBKE gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IKBKE for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q14164

    ProtoNet protein and cluster: Q14164

    UniProtKB/Swiss-Prot: IKKE_HUMAN, Q14164
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for IKBKE gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IKKE_HUMAN, Q14164
    Function: Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex
    and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells
    against DNA damage-induced cell death
    Catalytic activity: ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein]

    Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.101

    miRNA
    Products:            		miRTarBase miRNAs that target IKBKE:
    hsa-mir-155 (MIRT003484)

    OriGene 3'-UTR Clone: IKBKE
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IKBKE
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate IKBKE (see all 15):
    hsa-miR-98 hsa-miR-34b* hsa-miR-1321 hsa-miR-576-5p hsa-let-7d hsa-miR-2278 hsa-let-7c hsa-let-7i
    SwitchGear 3'UTR luciferase reporter plasmid: IKBKE 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IKBKE (see all 7)
    OriGene shRNA RFP: IKBKE
    OriGene siRNA: IKBKE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IKBKE

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IKBKE

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IKBKE (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IKBKE (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): IKBKE (NM_001193322)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IKBKE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKBKE 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IKBKE
    Search LifeMap BioReagents cell lines for IKBKE

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKBKE

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS--
    GO:0004704NF-kappaB-inducing kinase activity IDA10882136
    GO:0005515protein binding IPI--
    GO:0005524ATP binding NAS--
    GO:0008384IkappaB kinase activity IEA--


    IKBKE for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for IKBKE:
     Decreased focal adhesion (FA)   Weaker migration 

    Animal Models:
         Mouse knock-outs for IKBKE: Ikbketm1Tman Ikbketm1Aki
         6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ikbke):
     cellular  growth/size  homeostasis/metabolism  immune system  normal 
     respiratory system 

    IKBKE for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IKBKE gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/39 super-pathways (see all 39) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    14-1BB Pathway
    8/9 pathways (see all 9)
    		4-1BB Pathway1.00
    		NF-KappaB Activation by EBV0.31
    		CD40 Signaling0.54
    		SUMO Pathway0.30
    		CD27 Pathway0.48
    		TNFR2 Pathway0.29
    		CMV and MAPK Pathways0.38
    		NF-kappaB Activation by Viruses0.15
    2TWEAK Pathway
    8/9 pathways (see all 9)
    		TWEAK Pathway1.00
    		TNF Signaling0.40
    		DR3 Signaling0.87
    		Apoptotic Pathways Triggered By HIV10.37
    		TNFR1 Pathway0.53
    		Apoptosis through Death Receptors0.32
    		GITR Pathway0.46
    		Fas Signaling0.29
    3TRAF6 Mediated Induction of proinflammatory cytokines
    		TRIF-mediated TLR3/TLR4 signaling 0.73
    		Activated TLR4 signalling0.63
    		MyD88-independent cascade 0.72
    		Toll Like Receptor 4 (TLR4) Cascade0.61
    		Toll Like Receptor 3 (TLR3) Cascade0.72
    		Toll-Like Receptors Cascades0.53
    4BAFF in B-Cell Signaling
    		BAFF in B-Cell Signaling1.00
    		RANK Signaling in Osteoclasts0.45
    		APRIL Pathway0.92
    		RANK Pathway0.29
    5Toll-like receptor signaling pathway
    		Toll-like receptor signaling pathway1.00
    		Toll-Like receptor Signaling Pathways0.51
    		Toll-like receptor signaling pathway0.97
    		Inflammasome Activation Pathways0.29

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 R&D Systems Pathways for IKBKE
        Inflammasome Activation Pathways
    Toll-Like receptor Signaling Pathways

    5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IKBKE (see all 59)
        TWEAK Pathway
    14-3-3 Induced Apoptosis
    LT-BetaR Pathway
    Toll-Like Receptors Pathway
    Antioxidant Action of Vitamin-C

    1 Cell Signaling Technology (CST) Pathway for IKBKE
        NF-kappaB Signaling

    3 BioSystems Pathways for IKBKE 
        MicroRNAs in cardiomyocyte hypertrophy
    TNF-alpha/NF-kB Signaling Pathway
    Toll-like receptor signaling pathway

    5/13        Reactome Pathways for IKBKE (see all 13)
        RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    TRAF3-dependent IRF activation pathway
    Toll Like Receptor 4 (TLR4) Cascade
    TRAF6 mediated IRF7 activation
    Toll-Like Receptors Cascades


    5/6         Kegg Pathways  (Kegg details for IKBKE) (see all 6):
        Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathway
    Hepatitis C
    Measles


    IKBKE for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IKBKE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/385 Interacting proteins for IKBKE (Q141641, 2, 3 ENSP000003560874) via UniProtKB, MINT, STRING, and/or I2D (see all 385)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TANKQ928442, 3, ENSP000002590754MINT-5115012 MINT-8151307 MINT-8144241 MINT-8144064 MINT-8144154 MINT-8144107 I2D: score=5 STRING: ENSP00000259075
    TBK1Q9UHD22, 3, ENSP000003299674MINT-5114886 MINT-5208469 MINT-8144024 I2D: score=2 STRING: ENSP00000329967
    CALM1P621582, 3MINT-48113 I2D: score=2 
    CALM2P621582, 3MINT-48113 I2D: score=2 
    CALM3P621582, 3MINT-48113 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006468protein phosphorylation IDA--
    GO:0006955immune response NAS10421793
    GO:0007252I-kappaB phosphorylation ----
    GO:0008063Toll signaling pathway TAS--


    IKBKE for ontologies           About GeneDecksing



    Drugs & Compounds
    for IKBKE gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IKBKE for compounds           About GeneDecksing

    EMD Millipore small molecules for IKBKE:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IKBKE

    2 HMDB Compounds for IKBKE    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    9 Novoseek chemical compound relationships for IKBKE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 47.2 2 17599067 (1), 17328045 (1)
    poly(i-c) 44.8 1 17328045 (1)
    serine 25.6 5 12419799 (2), 11435419 (1), 14679297 (1), 10415047 (1)
    threonine 22.7 3 12419799 (2), 11435419 (1)
    phosphatidylinositol 7 1 14625285 (1)
    lipid 0 1 15597322 (1)
    calcium 0 1 12794154 (1)
    tyrosine 0 1 17056502 (1)
    h2o2 0 1 10754328 (1)

    Search CenterWatch for drugs/clinical trials and news about IKBKE / IKKE 

    Transcripts
    for IKBKE gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IKBKE gene (3 alternative transcripts): 
    NM_001193321.1  NM_001193322.1  NM_014002.3  

    Unigene Cluster for IKBKE:

    Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
    Hs.321045  [show with all ESTs]
    Unigene Representative Sequence: NM_014002
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367120(uc009xbu.2 uc001hdz.2 uc001hea.2 uc009xbv.2)
    ENST00000462698 ENST00000463979 ENST00000477884 ENST00000476449 ENST00000492570
    ENST00000537984

    miRNA
    Products:             		 OriGene 3'-UTR Clone: IKBKE
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IKBKE
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate IKBKE (see all 15):
    hsa-miR-98 hsa-miR-34b* hsa-miR-1321 hsa-miR-576-5p hsa-let-7d hsa-miR-2278 hsa-let-7c hsa-let-7i
    SwitchGear 3'UTR luciferase reporter plasmid: IKBKE 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IKBKE (see all 7)
    OriGene shRNA RFP: IKBKE
    OriGene siRNA: IKBKE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IKBKE
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IKBKE (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IKBKE (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): IKBKE (NM_001193322)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IKBKE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKBKE 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IKBKE
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IKBKE
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IKBKE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IKBKE

    Additional cDNA sequence: 

    AB016590.1 AF241789.1 AK057159.1 AK093798.1 AK310737.1 AY660028.1 BC105923.1 BC105924.1 
    BC107591.1 BC107812.1 D63485.1 XR_110846.2 XR_112003.2 XR_159156.2 XR_171246.1 

    10 DOTS entries:

    DT.95140441  DT.440820  DT.91765574  DT.95293172  DT.121418948  DT.95116200  DT.100715398  DT.121418933 
    DT.91765578  DT.95160201 

    24/96 AceView cDNA sequences (see all 96):

    AF241789 AY660028 BG754709 BM930283 AW269672 BQ061418 AI032348 CD743045 
    CB243308 CF140297 BG248299 AI458850 NM_014002 BM801295 AW083306 AI952553 
    BU196006 CD370061 BP364896 AU099468 AW006118 BU680463 BE396447 BU500812 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IKBKE    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                          -     -                                                                                                                           
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for IKBKE

    Expression
    for IKBKE gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IKBKE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See IKBKE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IKBKE

    SOURCE GeneReport for Unigene cluster: Hs.321045

    UniProtKB/Swiss-Prot: IKKE_HUMAN, Q14164
    Tissue specificity: Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta.
    Weakly expressed in lung, kidney, prostate, ovary and colon

        SABiosciences Expression via Pathway-Focused PCR Array including IKBKE: 
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    Primer
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    Orthologs
    for IKBKE gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for IKBKE gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IKBKE1 inhibitor of kappa light polypeptide gene enhancer more 69.52(n)
    64.19(a)    		   430480  XM_428036.3  XP_428036.3 
    lizard
    (Anolis carolinensis)    		 Reptilia IKBKE6
    		 --
    		 66(a)
    		 1 ↔ 1
    		 GL343228.1(1375034-1407307)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufk70c052 Transcribed sequence with moderate similarity to protein more 79.12(n)    CK353800.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta ik26
    		 IkappaB kinase-like 2
    		 34(a)
    		 1 → many
    		 2L(20676234-20679308)
    worm
    (Caenorhabditis elegans)    		 Secernentea T07F12.46
    Y39G8B.56
    (see all 3)    		 Protein Y39G8B.5
    (see all 3)    		 24(a)
    12(a)
    (see all 3)    		 possible ortholog
    many ↔ many
    (see all 3)    		 X(4896572-4898140)
    II(13987542-13991764)


    ENSEMBL Gene Tree for IKBKE (if available)
    TreeFam Gene Tree for IKBKE (if available) 

    Paralogs
    for IKBKE gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IKBKE gene
    IKBKB2  CHUK2  TBK12  
    1 SIMAP similar gene for IKBKE using alignment to 1 protein entry:     IKKE_HUMAN:
    TBK1

    IKBKE for paralogs           About GeneDecksing



    Genomic Variants
    for IKBKE gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/148 NCBI SNPs in IKBKE are shown (see all 148)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs412998481,2
    		C,F,--177363166(+) TGCTGT/CGGACG 1 -- nc-transcript-variant3Minor allele frequency- C:0.02NS CSA 94
    rs412998501,2
    		C,--177363190(+) CTTACG/AACAAG 1 -- nc-transcript-variant3Minor allele frequency- A:0.02NS WA 210
    rs412998521,2
    		C,F,--177363548(+) GGCAGT/CTGGCT 1 -- nc-transcript-variant3Minor allele frequency- C:0.05NS NA 214
    rs412998541,2
    		C,F,--177363636(+) GGTGAG/AGAAAC 1 -- nc-transcript-variant3Minor allele frequency- A:0.05NS WA 212
    rs412998581,2
    		C,F,--177363944(+) TCTCCA/GTCCCC 1 -- nc-transcript-variant6Minor allele frequency- G:0.07NS NA WA CSA 206
    rs798083981,2
    		--177363999(+) CCCACA/GTGCTA 1 -- nc-transcript-variant0--------
    rs170248051,2
    		C,F,H,--177364066(+) CACCCG/ATCCTC 1 -- nc-transcript-variant18Minor allele frequency- A:0.04NA NS EA WA CSA 1788
    rs412998601,2
    		C,F,--177364224(+) TTAACA/GGCTCT 1 -- nc-transcript-variant5Minor allele frequency- G:0.07NS WA CSA 204
    rs412998621,2
    		C,F,--177364511(+) GCAAGC/TGTGGA 1 -- nc-transcript-variant3Minor allele frequency- T:0.02NS WA 84
    rs412580641,2
    		C,F,--177364837(+) TCCTCC/AAGCAC 1 -- int17Minor allele frequency- A:0.14NS WA CSA NA 326

    HapMap Linkage Disequilibrium report for IKBKE (206643586 - 206670223 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IKBKE: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for IKBKE gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IKBKE for disorders           About GeneDecksing

    OMIM gene information: 605048    OMIM disorders: --

    20/28 diseases for IKBKE (see all 28):    About MalaCards
    breast cancer    dengue hemorrhagic fever    carcinoma    hemorrhagic fever
    major depressive disorder    breast carcinoma    ectodermal dysplasia    panic disorder
    rheumatoid arthritis    osteoarthritis    hepatitis c    stomatitis
    skin carcinoma    crohn's disease    arthritis    prostate cancer
    measles    t-cell leukemia    ovarian cancer    influenza

    10/11 Novoseek disease relationships for IKBKE gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 50.2 7 17376932 (1), 15210742 (1), 19307177 (1), 17056502 (1) (see all 6)
    necrosis 44.1 12 19307177 (2), 17259348 (2), 12829720 (1), 18703532 (1) (see all 6)
    leukemia t-cell 32.3 2 10906125 (1), 17145747 (1)
    tumors 25.5 23 19497997 (4), 19307177 (2), 17259348 (2), 12829720 (1) (see all 7)
    rheumatoid arthritis 13.3 1 17328045 (1)
    osteoarthritis 10.8 2 17328045 (1), 15879144 (1)
    shock 7.72 2 19437237 (1), 10799907 (1)
    inflammation 0 1 12730857 (1)
    breast cancer 0 2 19497997 (1)
    prostate cancer 0 3 17259348 (2), 12481431 (1)

    Human Genome Epidemiology (HuGE) Navigator: IKBKE (10 documents)

    Export disorders for IKBKE gene to outside databases

    Publications
    for IKBKE gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IKBKE gene, integrated from 9 sources (see all 196):
    (articles sorted by number of sources associating them with IKBKE)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. IKK epsilon is part of a novel PMA-inducible IkappaB kinase complex. (PubMed id 10882136)1, 2, 3 Peters R.T.... Maniatis T. (2000)
    2. IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. (PubMed id 10421793)1, 2, 3 Shimada T.... Akira S. (1999)
    3. SUMOylation-dependent localization of IKKepsilon in P ML nuclear bodies is essential for protection against DNA-damage-triggered cell death. (PubMed id 20188669)1, 2, 9 Renner F....Schmitz M.L. (2010)
    4. SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus- triggered IRF-3 activation pathways. (PubMed id 16281057)1, 2, 9 Huang J.... Shu H.-B. (2005)
    5. Identification of NAP1, a regulatory subunit of IkappaB kinase- related kinases that potentiates NF-kappaB signaling. (PubMed id 14560022)1, 2, 9 Fujita F.... Nakanishi M. (2003)
    6. The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response. (PubMed id 18636086)1, 2 Friedman C.S....Ting A.T. (2008)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. (PubMed id 16177806)1, 2 Meylan E.... Tschopp J. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2 Nagase T....Nomura N. (1995)

    External Searches for IKBKE gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IKBKE gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9641 HGNC: 14552 AceView: IKBKE Ensembl:ENSG00000143466 euGenes: HUgn9641
    ECgene: IKBKE Kegg: 9641 H-InvDB: IKBKE

    Other Databases showing IKBKE gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0151

    Specialized Databases showing IKBKE gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IKBKE Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/ikbke/

    Intellectual Property
    for IKBKE gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IKBKE gene:
    Search GeneIP for patents involving IKBKE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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