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IKBKE Gene

protein-coding   GIFtS: 65
GCID: GC01P206643

Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells,...

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase
Epsilon1 2
     IKK-Related Kinase Epsilon2
Inducible I Kappa-B Kinase2 3     Inducible IkappaB Kinase2
IKK-E2 3     Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Epsilon2
IKK-epsilon2 3     EC 2.7.11.103
IKK-i2 3     IkBKE3
IKKE2 3     KIAA01513
IKKI2 3     EC 2.7.118
I-Kappa-B Kinase Epsilon2 3     

External Ids:    HGNC: 145521   Entrez Gene: 96412   Ensembl: ENSG000001434667   OMIM: 6050485   UniProtKB: Q141643   

Export aliases for IKBKE gene to outside databases

Previous GC identifers: GC01P202354 GC01P203287 GC01P203727 GC01P203032 GC01P204710 GC01P177341


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IKBKE Gene:
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral
signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and
overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 (PubMed
19481526)).(supplied by OMIM, Oct 2009)

GeneCards Summary for IKBKE Gene:
IKBKE (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon) is a protein-coding gene. Diseases associated with IKBKE include west nile virus, and ectodermal dysplasia. GO annotations related to this gene include IkappaB kinase activity and protein kinase activity. An important paralog of this gene is IKBKB.

UniProtKB/Swiss-Prot: IKKE_HUMAN, Q14164
Function: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral
infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and
inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as
RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and
IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3
leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to
establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type
of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or
TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to
TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of
CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B
complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a
subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'.
Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3
(STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between
type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important
role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads
to a negative impact on insulin sensitivity. Phosphorylates AKT1

Gene Wiki entry for IKBKE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IKBKE gene promoter:
         COUP-TF1   C/EBPbeta   COUP   HNF-4alpha2   HNF-4alpha1   C/EBPalpha   RORalpha1   CHOP-10   COUP-TF   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIKBKE promoter sequence
   Search Chromatin IP Primers for IKBKE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IKBKE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q31

IKBKE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IKBKE gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P206643:  view genomic region     (about GC identifiers)

Start:
206,643,586 bp from pter      End:
206,670,223 bp from pter
Size:
26,638 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IKKE_HUMAN, Q14164 (See protein sequence)
Recommended Name: Inhibitor of nuclear factor kappa-B kinase subunit epsilon  
Size: 716 amino acids; 80462 Da
Subunit: Homodimer. Interacts with MAVS/IPS1. Interacts with the adapter proteins AZI2/NAP1, TANK and
TBKBP1/SINTBAD. Interacts with SIKE1. Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I; interactions are
disrupted by the interaction between IKBKE and SIKE1. Interacts with TOPORS; induced by DNA damage. Interacts
with CYLD. Interacts (when poylubiquitinated) with IKBKB, IKBKG and MYD88. Interacts with DDX3X; the interaction
is found to be induced upon virus infection. Interacts (via Protein kinase domain) with arenavirus protein N; the
interaction inhibits IKBKE kinase function. Interacts with Ebola virus protein VP35; the interaction leads to
inhibition of cellular antiviral response by blocking necessary interactions between the IKBKE and MAVS/IPS as
well as its substrates IRF3 and IRF7
Sequence caution: Sequence=BAA09772.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D3DT78 Q3B754 Q3KR43 Q5JTS6
Alternative splicing: 2 isoforms:  Q14164-1   Q14164-2   

Explore the universe of human proteins at neXtProt for IKBKE: NX_Q14164

Explore proteomics data for IKBKE at MOPED

Post-translational modifications: 

  • Autophosphorylated and phosphorylated by IKBKB/IKKB. Phosphorylation at Ser-172 is enhanced by the interaction
    with DDX3X. Phosphorylated at Thr-501 upon IFN activation1
  • Sumoylation by TOPORS upon DNA damage is required for protection of cells against DNA damage-induced cell death.
    Desumoylated by SENP11
  • 'Lys-63'-linked polyubiquitinated at Lys-30 and Lys-401 by TRAF2:BIRC2 and TRAF2:BIRC3 complexes. Ubiquitination
    is induced by LPS, TNFA and interleukin-1 and required for full kinase activity and KF-kappa-B pathway activation1
  • Ubiquitination2 at Lys549
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for IKBKE (Q14164) (see all 5)
     GPRRNKE  HRDIKPGN  YNEEQIHK  YHAATGSLPF 


    See IKBKE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001180250.1  NP_001180251.1  NP_054721.1  

    ENSEMBL proteins: 
     ENSP00000356087   ENSP00000444529  
    Reactome Protein details: Q14164

    IKBKE Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IKBKE
    OriGene Protein Over-expression Lysate for IKBKE
    OriGene MassSpec for IKBKE
    OriGene Custom Protein Services for IKBKE
    GenScript Custom Purified and Recombinant Proteins Services for IKBKE
    Novus Biologicals IKBKE Proteins
    Novus Biologicals IKBKE Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    IKBKE Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IKBKE
    R&D Systems Antibodies for IKBKE (IKK epsilon)
    Cell Signaling Technology (CST) Antibodies for IKBKE  (IKKE)
    OriGene Antibodies for IKBKE
    OriGene Custom Antibody Services for IKBKE
    Novus Biologicals IKBKE Antibodies
    Abcam antibodies for IKBKE
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for IKBKE
    LSBio Antibodies in human, mouse, rat for IKBKE

    IKBKE Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IKBKE
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IKBKE
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
    IKK family

    3 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q14164

    ProtoNet protein and cluster: Q14164

    UniProtKB/Swiss-Prot: IKKE_HUMAN, Q14164
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily
    Similarity: Contains 1 protein kinase domain


    IKBKE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IKKE_HUMAN, Q14164
    Function: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral
    infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and
    inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as
    RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and
    IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3
    leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to
    establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type
    of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or
    TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to
    TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of
    CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B
    complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a
    subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'.
    Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3
    (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between
    type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important
    role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads
    to a negative impact on insulin sensitivity. Phosphorylates AKT1
    Catalytic activity: ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein]
    Induction: Induced by lipopolysaccharide (LPS) and TNFA

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.101

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004704NF-kappaB-inducing kinase activity IDA10882136
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI14743216
    GO:0005524ATP binding IEA--
         
    IKBKE for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for IKBKE:
     Decreased focal adhesion (FA)   Weaker migration 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ikbke):
     cellular  growth/size/body  homeostasis/metabolism  immune system  normal 
     respiratory system 

    IKBKE for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IKBKE: Ikbketm1Aki Ikbketm1Tman

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IKBKE
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IKBKE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IKBKE
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IKBKE

    miRNA
    Products:
        
    miRTarBase miRNAs that target IKBKE:
    hsa-mir-155-5p (MIRT003484), hsa-mir-296-5p (MIRT006572), hsa-mir-124-3p (MIRT022344)

    Block miRNA regulation of human, mouse, rat IKBKE using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IKBKE (see all 15):
    hsa-miR-98 hsa-miR-34b* hsa-miR-1321 hsa-miR-576-5p hsa-let-7d hsa-miR-2278 hsa-let-7c hsa-let-7i
    SwitchGear 3'UTR luciferase reporter plasmidIKBKE 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IKBKE
    Predesigned siRNA for gene silencing in human, mouse, rat IKBKE

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IKBKE

    Clone
    Products:
         
    OriGene clones in human, mouse for IKBKE (see all 16)
    OriGene ORF clones in mouse, rat for IKBKE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IKBKE (NM_001193322)
    Sino Biological Human cDNA Clone for IKBKE
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IKBKE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKBKE

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IKBKE
    Browse ESI BIO Cell Lines and PureStem Progenitors for IKBKE 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKBKE


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IKKE_HUMAN, Q14164: Cytoplasm. Nucleus. Nucleus, PML body. Note=Targeting to PML nuclear bodies upon DNA damage
    is TOPORS-dependent
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    endosome4
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0010008endosome membrane TAS--

    IKBKE for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IKBKE About   (see all 38)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    TRAF6 mediated IRF7 activation0.40
    RIG-I-like receptor signaling pathway0.47
    TRAF3-dependent IRF activation pathway0.00
    Negative regulators of RIG-I/MDA5 signaling0.42
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    Hepatitis B0.31
    3TWEAK Pathway
    TWEAK Pathway0.87
    Apoptotic Pathways Triggered By HIV10.42
    DR3 Signaling0.87
    Apoptosis through Death Receptors0.42
    TNFR1 Pathway0.56
    TRAIL Pathway0.40
    TNF Signaling0.55
    Fas Signaling0.35
    44-1BB Pathway
    4-1BB Pathway0.54
    NF-kappaB Activation by Viruses0.42
    CD40 Signaling0.54
    TNFR2 Pathway0.37
    CD27 Pathway0.48
    PKR Pathway0.36
    CMV and MAPK Pathways0.46
    SUMO Pathway0.30
    5NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    IL-1 Family Signaling Pathways0.44
    NOD-like Receptor Signaling Pathways0.58
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    Inflammasome Activation Pathways0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for IKBKE (see all 7)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-1 Family Signaling Pathways
    IL-17 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IKBKE (see all 59)
        TWEAK Pathway
    14-3-3 Induced Apoptosis
    LT-BetaR Pathway
    Toll-Like Receptors Pathway
    Antioxidant Action of Vitamin-C

    1 Cell Signaling Technology (CST) Pathway for IKBKE
        NF-kappaB Signaling

    4 BioSystems Pathways for IKBKE
        MicroRNAs in cardiomyocyte hypertrophy
    Toll-like receptor signaling pathway
    TNF-alpha/NF-kB Signaling Pathway
    Regulation of toll-like receptor signaling pathway


    4 Reactome Pathways for IKBKE
        TRAF3-dependent IRF activation pathway
    Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
    Negative regulators of RIG-I/MDA5 signaling
    TRAF6 mediated IRF7 activation


    Selected Kegg Pathways  (Kegg details for IKBKE) (see all 8):
        Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathway
    Hepatitis C
    Hepatitis B


    IKBKE for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including IKBKE: 
              NFKB Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IKBKE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IKBKE (Q141641, 2, 3 ENSP000003560874) via UniProtKB, MINT, STRING, and/or I2D (see all 408)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TANKQ928441, 2, 3, ENSP000002590754EBI-307369,EBI-356349 MINT-5115012 MINT-8151307 MINT-8144241 MINT-8144064 MINT-8144154 MINT-8144107 I2D: score=5 STRING: ENSP00000259075
    TBK1Q9UHD21, 2, 3, ENSP000003299674EBI-307369,EBI-356402 MINT-5114886 MINT-5208469 MINT-8144024 I2D: score=2 STRING: ENSP00000329967
    HSP90AB1P082381, 2, 3, ENSP000003258754EBI-307369,EBI-352572 MINT-47963 MINT-48125 I2D: score=4 STRING: ENSP00000325875
    ENSG00000183311P074372, 3MINT-48114 I2D: score=2 
    ENSG00000224156P074372, 3MINT-48114 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006468protein phosphorylation IDA10882136
    GO:0006955immune response NAS10421793
    GO:0007252I-kappaB phosphorylation ----

    IKBKE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IKBKE (IKKE)

    2 HMDB Compounds for IKBKE    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    9 Novoseek inferred chemical compound relationships for IKBKE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 47.2 2 17599067 (1), 17328045 (1)
    poly(i-c) 44.8 1 17328045 (1)
    serine 25.6 5 12419799 (2), 11435419 (1), 14679297 (1), 10415047 (1)
    threonine 22.7 3 12419799 (2), 11435419 (1)
    phosphatidylinositol 7 1 14625285 (1)
    lipid 0 1 15597322 (1)
    calcium 0 1 12794154 (1)
    tyrosine 0 1 17056502 (1)
    h2o2 0 1 10754328 (1)



    IKBKE for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for IKBKE gene (3 alternative transcripts): 
    NM_001193321.1  NM_001193322.1  NM_014002.3  

    Unigene Cluster for IKBKE:

    Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
    Hs.321045  [show with all ESTs]
    Unigene Representative Sequence: NM_014002
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367120(uc009xbu.2 uc001hdz.2 uc001hea.2 uc009xbv.2)
    ENST00000463979 ENST00000492570 ENST00000537984
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IKBKE using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IKBKE (see all 15):
    hsa-miR-98 hsa-miR-34b* hsa-miR-1321 hsa-miR-576-5p hsa-let-7d hsa-miR-2278 hsa-let-7c hsa-let-7i
    SwitchGear 3'UTR luciferase reporter plasmidIKBKE 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IKBKE
    Predesigned siRNA for gene silencing in human, mouse, rat IKBKE
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    Additional mRNA sequence: 

    AB016590.1 AF241789.1 AK057159.1 AK093798.1 AK310737.1 AY660028.1 BC105923.1 BC105924.1 
    BC107591.1 BC107812.1 D63485.1 XR_110846.2 XR_112003.2 XR_159156.2 XR_171246.1 

    10 DOTS entries:

    DT.95140441  DT.440820  DT.91765574  DT.95293172  DT.121418948  DT.95116200  DT.100715398  DT.121418933 
    DT.91765578  DT.95160201 

    Selected AceView cDNA sequences (see all 96):

    AW269672 AI458850 AI032348 BG754709 CF140297 AY660028 AF241789 BQ061418 
    BM930283 CD743045 NM_014002 CB243308 BG248299 BU522088 BF339101 D63485 
    AW083306 AK093798 AW006118 AI830252 BM801295 BQ954714 CD367596 AA743048 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IKBKE    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                          -     -                                                                                                                           
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for IKBKE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IKBKE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IKBKE Expression
    About this image

    IKBKE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IKBKE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.321045

    UniProtKB/Swiss-Prot: IKKE_HUMAN, Q14164
    Tissue specificity: Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas,
    placenta. Weakly expressed in lung, kidney, prostate, ovary and colon

        Pathway & Disease-focused RT2 Profiler PCR Array including IKBKE: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for IKBKE gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ikbke1 , 5 inhibitor of kappaB kinase epsilon1, 5 83.01(n)1
    83.99(a)1
      1 (56.93 cM)5
    564891  NM_019777.31  NP_062751.21 
     1312543435 
    chicken
    (Gallus gallus)
    Aves IKBKE1 inhibitor of kappa light polypeptide gene enhancer more 69.47(n)
    64.1(a)
      430480  XM_004934960.1  XP_004935017.1 
    lizard
    (Anolis carolinensis)
    Reptilia IKBKE6
    inhibitor of kappa light polypeptide gene enhancer...
    61(a)
    1 ↔ 1
    GL343228.1(1371328-1431262)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ikbke1 inhibitor of kappa light polypeptide gene enhancer more 61.73(n)
    58.36(a)
      100487744  XM_002940511.2  XP_002940557.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk70c052 Transcribed sequence with moderate similarity to protein more 79.12(n)    CK353800.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ik26
    IkappaB kinase-like 2
    35(a)
    1 → many
    2L(20676234-20679308)
    worm
    (Caenorhabditis elegans)
    Secernentea Y39G8B.56
    ikke-16
    Protein IKKE-1, isoform c
    18(a)
    16(a)
    many ↔ many
    many ↔ many
    II(13987616-13991838) WBGene00012726
    III(9046011-9050693) WBGene00011299


    ENSEMBL Gene Tree for IKBKE (if available)
    TreeFam Gene Tree for IKBKE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IKBKE gene
    IKBKB2  CHUK2  TBK12  
    1 SIMAP similar gene for IKBKE using alignment to 1 protein entry:     IKKE_HUMAN:
    TBK1

    IKBKE for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IKBKE (see all 183)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs791489081,2
    F--206644067(+) GGGGGG/TTGGGG 3 -- int11Minor allele frequency- T:0.50NA 4
    rs1468503801,2
    C--206644843(+) GTCTGC/TGCTTT 3 -- int10--------
    rs412959741,2
    C--206645065(+) TCTGTG/TTAATG 3 -- int12Minor allele frequency- T:0.01NS 94
    rs574028381,2
    C--206645931(+) CTCTC-/CA/TC 
            
    ACACA
    3 -- int10--------
    rs3691891071,2
    C--206648175(+) GTGCCA/GTCCTC 3 -- int10--------
    rs557219471,2
    C--206648329(+) GCTGCA/GCTGTG 6 H R mis10--------
    rs412960221,2
    C,F--206649373(+) TGCATG/ATCTCT 3 -- int13Minor allele frequency- A:0.04NS NA 214
    rs1998271031,2
    C--206649985(+) GCCCTC/ACGGCT 3 -- int11Minor allele frequency- A:0.00EU 1191
    rs2021154631,2
    C--206650039(+) ATGAGC/TGGGCG 6 R W mis10--------
    rs412960401,2
    F--206650854(+) AGCAGA/C/GGGGGA 3 -- int12NS 94

    HapMap Linkage Disequilibrium report for IKBKE (206643586 - 206670223 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IKBKE:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv521n71CNV Loss21882294
    dgv522n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): IKBKE
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IKBKE
    DNA2.0 Custom Variant and Variant Library Synthesis for IKBKE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605048    OMIM disorders: --

    Selected diseases for IKBKE (see all 36):    About MalaCards
    west nile virus    ectodermal dysplasia    breast cancer    dengue hemorrhagic fever
    panic disorder    clear cell renal cell carcinoma    stomatitis    major depressive disorder
    hemorrhagic fever    measles    hepatitis c virus    renal cell carcinoma
    pancreatic ductal adenocarcinoma    kaposi's sarcoma    hepatitis c    rheumatoid arthritis
    influenza    crohn's disease    osteoarthritis    arthritis


    IKBKE for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for IKBKE gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 50.2 7 17376932 (1), 15210742 (1), 19307177 (1), 17056502 (1) (see all 6)
    necrosis 44.1 12 19307177 (2), 17259348 (2), 12829720 (1), 18703532 (1) (see all 6)
    leukemia t-cell 32.3 2 10906125 (1), 17145747 (1)
    tumors 25.5 23 19497997 (4), 19307177 (2), 17259348 (2), 12829720 (1) (see all 7)
    rheumatoid arthritis 13.3 1 17328045 (1)
    osteoarthritis 10.8 2 17328045 (1), 15879144 (1)
    shock 7.72 2 19437237 (1), 10799907 (1)
    inflammation 0 1 12730857 (1)
    breast cancer 0 2 19497997 (1)
    prostate cancer 0 3 17259348 (2), 12481431 (1)

    Genetic Association Database (GAD): IKBKE
    Human Genome Epidemiology (HuGE) Navigator: IKBKE (10 documents)

    Export disorders for IKBKE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IKBKE gene, integrated from 10 sources (see all 215):
    (articles sorted by number of sources associating them with IKBKE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IKK epsilon is part of a novel PMA-inducible IkappaB kinase complex. (PubMed id 10882136)1, 2, 3 Peters R.T.... Maniatis T. (Mol. Cell 2000)
    2. IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. (PubMed id 10421793)1, 2, 3 Shimada T.... Akira S. (Int. Immunol. 1999)
    3. SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death. (PubMed id 20188669)1, 2, 9 Renner F.... Schmitz M.L. (Mol. Cell 2010)
    4. SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus- triggered IRF-3 activation pathways. (PubMed id 16281057)1, 2, 9 Huang J.... Shu H.-B. (EMBO J. 2005)
    5. Identification of NAP1, a regulatory subunit of IkappaB kinase- related kinases that potentiates NF-kappaB signaling. (PubMed id 14560022)1, 2, 9 Fujita F.... Nakanishi M. (Mol. Cell. Biol. 2003)
    6. IKKI/-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex. (PubMed id 23453969)1, 2 Zhou A.Y....Hahn W.C. (Cell Rep 2013)
    7. Human DEAD box helicase 3 couples II_B kinase I/ to interferon regulatory factor 3 activation. (PubMed id 23478265)1, 2 Gu L....SchrAPder M. (Mol. Cell. Biol. 2013)
    8. Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKKI/. (PubMed id 22532683)1, 2 Pythoud C....Kunz S. (J. Virol. 2012)
    9. IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. (PubMed id 21464307)1, 2 Xie X....Guan K.L. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    10. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9641 HGNC: 14552 AceView: IKBKE Ensembl:ENSG00000143466 euGenes: HUgn9641
    ECgene: IKBKE Kegg: 9641 H-InvDB: IKBKE

    (According to HUGE)
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    HUGE: KIAA0151

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IKBKE Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/ikbke/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IKBKE gene:
    Search GeneIP for patents involving IKBKE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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