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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IKBKE Gene

protein-coding   GIFtS: 64
GCID: GC01P206643

Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells,...

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase
Epsilon1 2
     IKK-Related Kinase Epsilon2
Inducible I Kappa-B Kinase2 3     Inducible IkappaB Kinase2
IKK-E2 3     Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Epsilon2
IKK-epsilon2 3     EC 2.7.11.103
IKK-i2 3     IkBKE3
IKKE2 3     KIAA01513
IKKI2 3     EC 2.7.118
I-Kappa-B Kinase Epsilon2 3     

External Ids:    HGNC: 145521   Entrez Gene: 96412   Ensembl: ENSG000001434667   OMIM: 6050485   UniProtKB: Q141643   

Export aliases for IKBKE gene to outside databases

Previous GC identifers: GC01P202354 GC01P203287 GC01P203727 GC01P203032 GC01P204710 GC01P177341


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IKBKE Gene:
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral
signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and
overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 (PubMed
19481526)).(supplied by OMIM, Oct 2009)

GeneCards Summary for IKBKE Gene: 
IKBKE (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon) is a protein-coding gene. Diseases associated with IKBKE include dengue hemorrhagic fever, and major depressive disorder, and among its related super-pathways are Toll-like receptor signaling pathway and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include IkappaB kinase activity and protein kinase activity. An important paralog of this gene is IKBKB.

UniProtKB/Swiss-Prot: IKKE_HUMAN, Q14164
Function: Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B
complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects
cells against DNA damage-induced cell death

Gene Wiki entry for IKBKE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IKBKE gene promoter:
         COUP-TF1   C/EBPbeta   COUP   HNF-4alpha2   HNF-4alpha1   C/EBPalpha   RORalpha1   CHOP-10   COUP-TF   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIKBKE promoter sequence
   Search SABiosciences Chromatin IP Primers for IKBKE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IKBKE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q31

IKBKE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IKBKE gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P206643:  view genomic region     (about GC identifiers)

Start:
206,643,586 bp from pter      End:
206,670,223 bp from pter
Size:
26,638 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IKKE_HUMAN, Q14164 (See protein sequence)
Recommended Name: Inhibitor of nuclear factor kappa-B kinase subunit epsilon  
Size: 716 amino acids; 80462 Da
Subunit: May interact with MAVS/IPS1. Interacts with AZI2. Interacts with SIKE1. Interacts with TICAM1/TRIF, IRF3
and DDX58/RIG-I, interactions are disrupted by the interaction between IKBKE and SIKE1. Interacts with TOPORS;
induced by DNA damage. Interacts with CYLD
Subcellular location: Cytoplasm. Nucleus. Nucleus, PML body. Note=Targeting to PML nuclear bodies upon DNA damage
is TOPORS-dependent
Sequence caution: Sequence=BAA09772.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D3DT78 Q3B754 Q3KR43 Q5JTS6
Alternative splicing: 2 isoforms:  Q14164-1   Q14164-2   

Explore the universe of human proteins at neXtProt for IKBKE: NX_Q14164

Explore proteomics data for IKBKE at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated and phosphorylated by IKBKB/IKKB
  • UniProtKB: Sumoylation by TOPORS upon DNA damage is required for protection of cells against DNA damage-induced cell death.
    Desumoylated by SENP1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14164

  • 4/5 DME Specific Peptides for IKBKE (Q14164) (see all 5)
     GPRRNKE  HRDIKPGN  YNEEQIHK  YHAATGSLPF 

    IKBKE Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IKBKE Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001180250.1  NP_001180251.1  NP_054721.1  

    ENSEMBL proteins: 
     ENSP00000356087   ENSP00000444529  
    Reactome Protein details: Q14164
    Human Recombinant Protein Products for IKBKE: 
    EMD Millipore Purified and/or Recombinant IKBKE Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IKBKE
    OriGene Protein Over-expression Lysate for IKBKE
    OriGene MassSpec for IKBKE 
    OriGene Custom Protein Services for IKBKE
    GenScript Custom Purified and Recombinant Proteins Services for IKBKE
    Novus Biologicals IKBKE Proteins
    Novus Biologicals IKBKE Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0010008endosome membrane TAS--

    IKBKE for ontologies           About GeneDecksing



    IKBKE Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IKBKE
    R&D Systems Antibodies for IKBKE (IKK epsilon)
    Cell Signaling Technology (CST) Antibodies for IKBKE  (IKKE)
    OriGene Antibodies for IKBKE
    OriGene Custom Antibody Services for IKBKE
    GenScript Custom Superior Antibodies Services for IKBKE
    Novus Biologicals IKBKE Antibodies
    Abcam antibodies for IKBKE
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for IKBKE
    LSBio Antibodies in human, mouse, rat for IKBKE 

    Assay Products for IKBKE: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IKBKE
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 
    IKK family

    3 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q14164

    ProtoNet protein and cluster: Q14164

    UniProtKB/Swiss-Prot: IKKE_HUMAN, Q14164
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily
    Similarity: Contains 1 protein kinase domain


    IKBKE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IKKE_HUMAN, Q14164
    Function: Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B
    complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects
    cells against DNA damage-induced cell death
    Catalytic activity: ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein]

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.101

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS--
    GO:0004704NF-kappaB-inducing kinase activity IDA10882136
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16177806
    GO:0005524ATP binding NAS--
         
    IKBKE for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for IKBKE:
     Decreased focal adhesion (FA)   Weaker migration 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ikbke):
     cellular  growth/size  homeostasis/metabolism  immune system  normal 
     respiratory system 

    IKBKE for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IKBKE: Ikbketm1Aki Ikbketm1Tman

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IKBKE 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IKBKE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IKBKE 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IKBKE 

    miRNA
    Products:
        
    miRTarBase miRNAs that target IKBKE:
    hsa-mir-155 (MIRT003484)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IKBKE
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate IKBKE (see all 15):
    hsa-miR-98 hsa-miR-34b* hsa-miR-1321 hsa-miR-576-5p hsa-let-7d hsa-miR-2278 hsa-let-7c hsa-let-7i
    SwitchGear 3'UTR luciferase reporter plasmidIKBKE 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IKBKE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IKBKE

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IKBKE
    Sirion Biotech Customized adenovirus for overexpression of IKBKE

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IKBKE (see all 13)
    OriGene ORF clones in mouse, rat for IKBKE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): IKBKE (NM_001193322)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IKBKE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKBKE
    Sirion Biotech Customized lentivirus for stable overexpression of IKBKE 
                         Customized lentivirus expression plasmids for stable overexpression of IKBKE 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IKBKE
    Search LifeMap BioReagents cell lines for IKBKE
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKBKE


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IKBKE About   (see all 41)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Hepatitis B0.31
    Toll-like receptor signaling pathway0.93
    2RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.52
    Negative regulators of RIG-I/MDA5 signaling0.49
    RIG-I-like receptor signaling pathway0.52
    3TWEAK Pathway
    TWEAK Pathway0.87
    Apoptotic Pathways Triggered By HIV10.42
    DR3 Signaling0.87
    Apoptosis through Death Receptors0.42
    TNFR1 Pathway0.56
    TRAIL Pathway0.40
    TNF Signaling0.55
    Fas Signaling0.35
    44-1BB Pathway
    4-1BB Pathway0.54
    NF-kappaB Activation by Viruses0.42
    CD40 Signaling0.54
    TNFR2 Pathway0.37
    CD27 Pathway0.48
    PKR Pathway0.36
    CMV and MAPK Pathways0.46
    SUMO Pathway0.30
    5TRAF6 Mediated Induction of proinflammatory cytokines
    Activated TLR4 signalling0.87
    Toll Like Receptor 4 (TLR4) Cascade0.87
    MyD88-independent cascade 0.87
    Toll-Like Receptors Cascades0.87
    Toll Like Receptor 3 (TLR3) Cascade0.87
    TRIF-mediated TLR3/TLR4 signaling 0.86

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 R&D Systems Pathways for IKBKE (see all 6)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-17 Signaling
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    5/59 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IKBKE (see all 59)
        TWEAK Pathway
    14-3-3 Induced Apoptosis
    LT-BetaR Pathway
    Toll-Like Receptors Pathway
    Antioxidant Action of Vitamin-C

    1 Cell Signaling Technology (CST) Pathway for IKBKE
        NF-kappaB Signaling

    3 BioSystems Pathways for IKBKE
        MicroRNAs in cardiomyocyte hypertrophy
    Toll-like receptor signaling pathway
    TNF-alpha/NF-kB Signaling Pathway

    5/13        Reactome Pathways for IKBKE (see all 13)
        RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    TRAF3-dependent IRF activation pathway
    Toll Like Receptor 4 (TLR4) Cascade
    TRAF6 mediated IRF7 activation
    Toll-Like Receptors Cascades


    5/8         Kegg Pathways  (Kegg details for IKBKE) (see all 8):
        Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathway
    Hepatitis C
    Hepatitis B


    IKBKE for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IKBKE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/401 Interacting proteins for IKBKE (Q141641, 2, 3 ENSP000003560874) via UniProtKB, MINT, STRING, and/or I2D (see all 401)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000183311P074372, 3MINT-48114 I2D: score=2 
    ENSG00000224156P074372, 3MINT-48114 I2D: score=2 
    ENSG00000227739P074372, 3MINT-48114 I2D: score=2 
    ENSG00000229684P074372, 3MINT-48114 I2D: score=2 
    ENSG00000232421P074372, 3MINT-48114 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006468protein phosphorylation IDA10882136
    GO:0006955immune response NAS10421793
    GO:0007252I-kappaB phosphorylation ----

    IKBKE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IKBKE for compounds           About GeneDecksing

    EMD Millipore small molecules for IKBKE:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IKBKE (IKKE)

    2 HMDB Compounds for IKBKE    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    9 Novoseek inferred chemical compound relationships for IKBKE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 47.2 2 17599067 (1), 17328045 (1)
    poly(i-c) 44.8 1 17328045 (1)
    serine 25.6 5 12419799 (2), 11435419 (1), 14679297 (1), 10415047 (1)
    threonine 22.7 3 12419799 (2), 11435419 (1)
    phosphatidylinositol 7 1 14625285 (1)
    lipid 0 1 15597322 (1)
    calcium 0 1 12794154 (1)
    tyrosine 0 1 17056502 (1)
    h2o2 0 1 10754328 (1)

    Search CenterWatch for drugs/clinical trials and news about IKBKE / IKKE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IKBKE gene (3 alternative transcripts): 
    NM_001193321.1  NM_001193322.1  NM_014002.3  

    Unigene Cluster for IKBKE:

    Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
    Hs.321045  [show with all ESTs]
    Unigene Representative Sequence: NM_014002
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367120(uc009xbu.2 uc001hdz.2 uc001hea.2 uc009xbv.2)
    ENST00000462698 ENST00000463979 ENST00000476449 ENST00000492570 ENST00000537984

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IKBKE
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate IKBKE (see all 15):
    hsa-miR-98 hsa-miR-34b* hsa-miR-1321 hsa-miR-576-5p hsa-let-7d hsa-miR-2278 hsa-let-7c hsa-let-7i
    SwitchGear 3'UTR luciferase reporter plasmidIKBKE 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): IKBKE (NM_001193322)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IKBKE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKBKE
    Sirion Biotech Customized lentivirus for stable overexpression of IKBKE 
                         Customized lentivirus expression plasmids for stable overexpression of IKBKE 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IKBKE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IKBKE

    Additional mRNA sequence: 

    AB016590.1 AF241789.1 AK057159.1 AK093798.1 AK310737.1 AY660028.1 BC105923.1 BC105924.1 
    BC107591.1 BC107812.1 D63485.1 XR_110846.2 XR_112003.2 XR_159156.2 XR_171246.1 

    10 DOTS entries:

    DT.95140441  DT.440820  DT.91765574  DT.95293172  DT.121418948  DT.95116200  DT.100715398  DT.121418933 
    DT.91765578  DT.95160201 

    24/96 AceView cDNA sequences (see all 96):

    AI458850 CD743045 AW269672 BG754709 CB243308 AF241789 AY660028 CF140297 
    NM_014002 BQ061418 AI032348 BM930283 BG248299 BQ954714 CA944992 BI226990 
    AK093798 CD367596 BM765117 BM801295 BU680463 AU099468 BX349367 AL706097 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IKBKE    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                          -     -                                                                                                                           
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    ECgene alternative splicing isoforms for IKBKE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IKBKE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IKBKE Expression
    About this image


    See IKBKE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IKBKE

    SOURCE GeneReport for Unigene cluster: Hs.321045

    UniProtKB/Swiss-Prot: IKKE_HUMAN, Q14164
    Tissue specificity: Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas,
    placenta. Weakly expressed in lung, kidney, prostate, ovary and colon

        SABiosciences Expression via Pathway-Focused PCR Array including IKBKE: 
              NFKB Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for IKBKE gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ikbke1 , 5 inhibitor of kappaB kinase epsilon1, 5 83.01(n)1
    83.99(a)1
      1 (56.93 cM)5
    564891  NM_019777.31  NP_062751.21 
     1312543435 
    chicken
    (Gallus gallus)
    Aves IKBKE1 inhibitor of kappa light polypeptide gene enhancer more 69.52(n)
    64.19(a)
      430480  XM_428036.3  XP_428036.3 
    lizard
    (Anolis carolinensis)
    Reptilia IKBKE6
    inhibitor of kappa light polypeptide gene enhancer...
    61(a)
    1 ↔ 1
    GL343228.1(1371328-1431262)
    zebrafish
    (Danio rerio)
    Actinopterygii wufk70c052 Transcribed sequence with moderate similarity to protein more 79.12(n)    CK353800.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ik26
    IkappaB kinase-like 2
    35(a)
    1 → many
    2L(20676234-20679308)
    worm
    (Caenorhabditis elegans)
    Secernentea Y39G8B.56
    ikke-16
    Protein Y39G8B.5
    Inhibitor of nuclear factor kappa-B kinase epsilon...
    17(a)
    16(a)
    many ↔ many
    many ↔ many
    II(13987616-13991838)
    III(9046011-9050695)


    ENSEMBL Gene Tree for IKBKE (if available)
    TreeFam Gene Tree for IKBKE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IKBKE gene
    IKBKB2  CHUK2  TBK12  
    1 SIMAP similar gene for IKBKE using alignment to 1 protein entry:     IKKE_HUMAN:
    TBK1

    IKBKE for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/183 SNPs in IKBKE are shown (see all 183)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0405714
    ----see VAR_0405712 T M mis40--------
    VAR_0388184
    ----see VAR_0388182 E D mis40--------
    VAR_0388164
    ----see VAR_0388162 E K mis40--------
    VAR_0199894
    ----see VAR_0199892 P L mis40--------
    VAR_0405724
    ----see VAR_0405722 G E mis40--------
    VAR_0388194
    ----see VAR_0388192 I M mis40--------
    VAR_0388174
    ----see VAR_0388172 A T mis40--------
    VAR_0388204
    ----see VAR_0388202 A V mis40--------
    rs791489081,2
    F--206644067(+) GGGGGG/TTGGGG 3 -- int11Minor allele frequency- T:0.50NA 4
    rs1468503801,2
    C--206644843(+) GTCTGC/TGCTTT 3 -- int10--------

    HapMap Linkage Disequilibrium report for IKBKE (206643586 - 206670223 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IKBKE:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv521n71CNV Loss21882294
    dgv522n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605048    OMIM disorders: --

    20/29 diseases for IKBKE (see all 29):    About MalaCards
    dengue hemorrhagic fever    major depressive disorder    breast cancer    west nile virus
    panic disorder    ectodermal dysplasia    stomatitis    hemorrhagic fever
    measles    clear cell renal cell carcinoma    rheumatoid arthritis    crohn's disease
    hepatitis c    influenza    prostate cancer    kaposi's sarcoma
    arthritis    t-cell leukemia    melanoma    pancreatic cancer


    IKBKE for disorders           About GeneDecksing

    10/11 Novoseek inferred disease relationships for IKBKE gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 50.2 7 17376932 (1), 15210742 (1), 19307177 (1), 17056502 (1) (see all 6)
    necrosis 44.1 12 19307177 (2), 17259348 (2), 12829720 (1), 18703532 (1) (see all 6)
    leukemia t-cell 32.3 2 10906125 (1), 17145747 (1)
    tumors 25.5 23 19497997 (4), 19307177 (2), 17259348 (2), 12829720 (1) (see all 7)
    rheumatoid arthritis 13.3 1 17328045 (1)
    osteoarthritis 10.8 2 17328045 (1), 15879144 (1)
    shock 7.72 2 19437237 (1), 10799907 (1)
    inflammation 0 1 12730857 (1)
    breast cancer 0 2 19497997 (1)
    prostate cancer 0 3 17259348 (2), 12481431 (1)

    Genetic Association Database (GAD): IKBKE
    Human Genome Epidemiology (HuGE) Navigator: IKBKE (10 documents)

    Export disorders for IKBKE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IKBKE gene, integrated from 9 sources (see all 208):
    (articles sorted by number of sources associating them with IKBKE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IKK epsilon is part of a novel PMA-inducible IkappaB kinase complex. (PubMed id 10882136)1, 2, 3 Peters R.T.... Maniatis T. (2000)
    2. IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. (PubMed id 10421793)1, 2, 3 Shimada T.... Akira S. (1999)
    3. SUMOylation-dependent localization of IKKepsilon in P ML nuclear bodies is essential for protection against DNA-damage-triggered cell death. (PubMed id 20188669)1, 2, 9 Renner F....Schmitz M.L. (2010)
    4. SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus- triggered IRF-3 activation pathways. (PubMed id 16281057)1, 2, 9 Huang J.... Shu H.-B. (2005)
    5. Identification of NAP1, a regulatory subunit of IkappaB kinase- related kinases that potentiates NF-kappaB signaling. (PubMed id 14560022)1, 2, 9 Fujita F.... Nakanishi M. (2003)
    6. Dengue hemorrhagic fever is associated with polymorph isms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (2010)
    7. Interleukin 10 family gene polymorphisms are not asso ciated with major depressive disorder and panic disorder phenotypes. (PubMed id 19786281)1, 4 Koido K....Maron E. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    10. The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response. (PubMed id 18636086)1, 2 Friedman C.S....Ting A.T. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9641 HGNC: 14552 AceView: IKBKE Ensembl:ENSG00000143466 euGenes: HUgn9641
    ECgene: IKBKE Kegg: 9641 H-InvDB: IKBKE

    (According to HUGE)
    About This Section
    HUGE: KIAA0151

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IKBKE Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/ikbke/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IKBKE gene:
    Search GeneIP for patents involving IKBKE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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