Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IKBKE Gene

Aliases for IKBKE Gene

  • Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon 2 3 5
  • Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Epsilon 2 3
  • Inducible I Kappa-B Kinase 3 4
  • I-Kappa-B Kinase Epsilon 3 4
  • IKK-Epsilon 3 4
  • IKK-E 3 4
  • IKK-I 3 4
  • IKKE 3 4
  • IKKI 3 4
  • Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Epsilon 3
  • IKK-Related Kinase Epsilon 3
  • Inducible IkappaB Kinase 3
  • EC 2.7.11.10 4
  • EC 2.7.11 58
  • KIAA0151 4
  • IkBKE 4

External Ids for IKBKE Gene

Previous GeneCards Identifiers for IKBKE Gene

  • GC01P202354
  • GC01P203287
  • GC01P203727
  • GC01P203032
  • GC01P204710
  • GC01P206643
  • GC01P177341

Summaries for IKBKE Gene

Entrez Gene Summary for IKBKE Gene

  • IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]

GeneCards Summary for IKBKE Gene

IKBKE (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon) is a Protein Coding gene. Diseases associated with IKBKE include Rabies. Among its related pathways are 4-1BB Pathway and TNFR1 Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TBK1.

UniProtKB/Swiss-Prot for IKBKE Gene

  • Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at Ser-708. Phosphorylation of STAT1 at Ser-708 seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.

Gene Wiki entry for IKBKE Gene

Additional gene information for IKBKE Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IKBKE Gene

Genomics for IKBKE Gene

Regulatory Elements for IKBKE Gene

Enhancers for IKBKE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H206510 1.8 FANTOM5 Ensembl ENCODE dbSUPER 25.1 +42.8 42825 4.6 HDAC1 TBP PKNOX1 BRCA1 RFX5 YY1 ZNF766 ELK1 RCOR1 FOS ENSG00000261000 IKBKE RASSF5 ELK4 EIF2D MAPKAPK2 RPL7AP20
GH01H206480 0.8 ENCODE 46.4 +11.0 11040 1 JUN EBF1 BATF ZIC2 RELA FOSL1 GLIS2 CTBP1 POLR2A EGR1 IKBKE ENSG00000261000 MIR6769B C1orf147
GH01H206573 2 FANTOM5 Ensembl ENCODE dbSUPER 14.4 +108.5 108519 11.1 HDGF PKNOX1 ATF1 ARNT ZNF2 YY1 ZNF766 GATA2 ELK1 ZNF207 RASSF5 EIF2D MAPKAPK2 IKBKE ELK4 C1orf147 DYRK3 IL19 FCMR PIR41610
GH01H206503 1.5 Ensembl ENCODE dbSUPER 18.8 +33.8 33807 1.6 ATF1 ARNT ZNF766 CBX5 ELK1 FOS ATF7 RUNX3 DEK MCM3 ENSG00000261000 IKBKE EIF2D ELK4 RASSF5
GH01H206657 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.2 +188.6 188577 3.4 HDGF ARNT YY1 TCF12 GLIS2 GATA2 ZNF143 ATF7 RUNX3 NCOA1 DYRK3 IKBKE MAPKAPK2 EIF2D C1orf147 RASSF5 PIR60472 LOC105372875
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IKBKE on UCSC Golden Path with GeneCards custom track

Promoters for IKBKE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000018976 657 1001 ELF3 TBP HDGF PKNOX1 RB1 SIN3A RAD21 ZNF766 GLIS2 ZNF143

Genomic Locations for IKBKE Gene

Genomic Locations for IKBKE Gene
chr1:206,470,243-206,496,890
(GRCh38/hg38)
Size:
26,648 bases
Orientation:
Plus strand
chr1:206,643,586-206,670,223
(GRCh37/hg19)

Genomic View for IKBKE Gene

Genes around IKBKE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IKBKE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IKBKE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IKBKE Gene

Proteins for IKBKE Gene

  • Protein details for IKBKE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14164-IKKE_HUMAN
    Recommended name:
    Inhibitor of nuclear factor kappa-B kinase subunit epsilon
    Protein Accession:
    Q14164
    Secondary Accessions:
    • D3DT78
    • Q3B754
    • Q3KR43
    • Q5JTS6

    Protein attributes for IKBKE Gene

    Size:
    716 amino acids
    Molecular mass:
    80462 Da
    Quaternary structure:
    • Homodimer. Interacts with MAVS/IPS1. Interacts with the adapter proteins AZI2/NAP1, TANK and TBKBP1/SINTBAD. Interacts with SIKE1. Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I; interactions are disrupted by the interaction between IKBKE and SIKE1. Interacts with TOPORS; induced by DNA damage. Interacts with CYLD. Interacts (when polyubiquitinated) with IKBKB, IKBKG and MYD88. Interacts with IFIH1 (PubMed:17600090). Interacts with DDX3X; the interaction is found to be induced upon virus infection. Interacts (via Protein kinase domain) with arenavirus protein N; the interaction inhibits IKBKE kinase function. Interacts with Ebola virus protein VP35; the interaction leads to inhibition of cellular antiviral response by blocking necessary interactions between the IKBKE and MAVS/IPS as well as its substrates IRF3 and IRF7. Interacts with TRIM6 (via SPRY box) (PubMed:24882218). Interacts with unanchored K48-linked polyubiquitin chains; this leads to IKBKE activation (PubMed:24882218).
    SequenceCaution:
    • Sequence=BAA09772.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for IKBKE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IKBKE Gene

Selected DME Specific Peptides for IKBKE Gene

Q14164:
  • YGTEEYLHPDMYERAVLRK
  • YHAATGSLPF
  • YNEEQIHK
  • GPRRNKE
  • HRDIKPGN

Post-translational modifications for IKBKE Gene

  • Autophosphorylated and phosphorylated by IKBKB/IKKB. Phosphorylation at Ser-172 is enhanced by the interaction with DDX3X. Phosphorylated at Thr-501 upon IFN activation.
  • Lys-63-linked polyubiquitinated at Lys-30 and Lys-401 by TRAF2:BIRC2 and TRAF2:BIRC3 complexes. Ubiquitination is induced by LPS, TNFA and interleukin-1 and required for full kinase activity and KF-kappa-B pathway activation.
  • Sumoylation by TOPORS upon DNA damage is required for protection of cells against DNA damage-induced cell death. Desumoylated by SENP1.
  • Ubiquitination at isoforms=30, posLast=401401, and isoforms=2549
  • Modification sites at PhosphoSitePlus

Domains & Families for IKBKE Gene

Gene Families for IKBKE Gene

Protein Domains for IKBKE Gene

Suggested Antigen Peptide Sequences for IKBKE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14164

UniProtKB/Swiss-Prot:

IKKE_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
genes like me logo Genes that share domains with IKBKE: view

Function for IKBKE Gene

Molecular function for IKBKE Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at Ser-708. Phosphorylation of STAT1 at Ser-708 seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.
UniProtKB/Swiss-Prot Induction:
Induced by lipopolysaccharide (LPS) and TNFA.

Enzyme Numbers (IUBMB) for IKBKE Gene

Phenotypes From GWAS Catalog for IKBKE Gene

Gene Ontology (GO) - Molecular Function for IKBKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS,IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004704 NF-kappaB-inducing kinase activity IDA 10882136
GO:0005515 protein binding IPI 14743216
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with IKBKE: view
genes like me logo Genes that share phenotypes with IKBKE: view

Animal Models for IKBKE Gene

MGI Knock Outs for IKBKE:

Animal Model Products

miRNA for IKBKE Gene

miRTarBase miRNAs that target IKBKE

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IKBKE

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IKBKE Gene

Localization for IKBKE Gene

Subcellular locations from UniProtKB/Swiss-Prot for IKBKE Gene

Cytoplasm. Nucleus. Nucleus, PML body. Note=Targeting to PML nuclear bodies upon DNA damage is TOPORS-dependent (PubMed:20188669). Located diffusely throughout the cytoplasm but locates to punctate cytoplasmic bodies when coexpressed with TRIM6 (PubMed:24882218). {ECO:0000269 PubMed:20188669, ECO:0000269 PubMed:24882218}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IKBKE gene
Compartment Confidence
nucleus 5
cytosol 5
endosome 4
mitochondrion 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IKBKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 20188669
GO:0005737 cytoplasm IEA,IDA 20188669
GO:0005829 cytosol TAS --
GO:0010008 endosome membrane TAS --
GO:0016605 PML body IEA,IDA 20188669
genes like me logo Genes that share ontologies with IKBKE: view

Pathways & Interactions for IKBKE Gene

SuperPathways for IKBKE Gene

SuperPathway Contained pathways
1 4-1BB Pathway
2 TNFR1 Pathway
3 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
4 Activated TLR4 signalling
5 Toll-Like receptor Signaling Pathways
genes like me logo Genes that share pathways with IKBKE: view

SIGNOR curated interactions for IKBKE Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for IKBKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 10882136
GO:0006955 immune response NAS 10421793
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007252 I-kappaB phosphorylation IEA --
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP 20188669
genes like me logo Genes that share ontologies with IKBKE: view

Drugs & Compounds for IKBKE Gene

(9) Drugs for IKBKE Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
BMS-345541 Pharma IKK inhibitor,highly selective 0
IKK-3 Inhibitor Pharma IKK-3 Inhibitor 0
IKKε-IN-1 Pharma 0
MRT67307 Pharma SIK/TBK-1/IKKe inhibitor 0
ATP Nutra Agonist 0

(6) Additional Compounds for IKBKE Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(4) ApexBio Compounds for IKBKE Gene

Compound Action Cas Number
BMS-345541 IKK inhibitor,highly selective 547757-23-3
IKK-3 Inhibitor IKK-3 Inhibitor 862812-98-4
IKKε-IN-1 1292310-49-6
MRT67307 SIK/TBK-1/IKKe inhibitor 1190378-57-4
genes like me logo Genes that share compounds with IKBKE: view

Drug Products

Transcripts for IKBKE Gene

Unigene Clusters for IKBKE Gene

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for IKBKE

Alternative Splicing Database (ASD) splice patterns (SP) for IKBKE Gene

No ASD Table

Relevant External Links for IKBKE Gene

GeneLoc Exon Structure for
IKBKE
ECgene alternative splicing isoforms for
IKBKE

Expression for IKBKE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IKBKE Gene

mRNA differential expression in normal tissues according to GTEx for IKBKE Gene

This gene is overexpressed in Whole Blood (x6.9).

Protein differential expression in normal tissues from HIPED for IKBKE Gene

This gene is overexpressed in Lung (20.6), Peripheral blood mononuclear cells (13.0), and Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IKBKE Gene



Protein tissue co-expression partners for IKBKE Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IKBKE Gene:

IKBKE

SOURCE GeneReport for Unigene cluster for IKBKE Gene:

Hs.321045

mRNA Expression by UniProt/SwissProt for IKBKE Gene:

Q14164-IKKE_HUMAN
Tissue specificity: Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.

Evidence on tissue expression from TISSUES for IKBKE Gene

  • Blood(4.4)
  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with IKBKE: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IKBKE Gene

Orthologs for IKBKE Gene

This gene was present in the common ancestor of chordates.

Orthologs for IKBKE Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia IKBKE 33
  • 89.44 (n)
cow
(Bos Taurus)
Mammalia IKBKE 33
  • 87.76 (n)
rat
(Rattus norvegicus)
Mammalia Ikbke 33
  • 83.1 (n)
mouse
(Mus musculus)
Mammalia Ikbke 33 16
  • 83.01 (n)
chicken
(Gallus gallus)
Aves IKBKE 33
  • 69.47 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ikbke 33
  • 61.73 (n)
zebrafish
(Danio rerio)
Actinopterygii ikbke 33
  • 56.6 (n)
wufk70c05 33
Species where no ortholog for IKBKE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IKBKE Gene

ENSEMBL:
Gene Tree for IKBKE (if available)
TreeFam:
Gene Tree for IKBKE (if available)

Paralogs for IKBKE Gene

Paralogs for IKBKE Gene

(1) SIMAP similar genes for IKBKE Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IKBKE: view

Variants for IKBKE Gene

Sequence variations from dbSNP and Humsavar for IKBKE Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000006689 -- 206,491,396(+) CATGT(A/G)TGTTC intron-variant
rs1000127807 -- 206,485,405(+) ATTCC(C/T)CTTTC intron-variant
rs1000180372 -- 206,485,222(+) CTCCC(A/C)AAATA nc-transcript-variant, reference, missense
rs1000417815 -- 206,474,199(+) TCCAA(C/G)CAGGC intron-variant, upstream-variant-2KB
rs1000516208 -- 206,486,480(+) AGGCT(A/G)TGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IKBKE Gene

Variant ID Type Subtype PubMed ID
nsv549068 CNV gain 21841781
dgv564n100 CNV gain 25217958

Variation tolerance for IKBKE Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.88; 87.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IKBKE Gene

Human Gene Mutation Database (HGMD)
IKBKE
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IKBKE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IKBKE Gene

Disorders for IKBKE Gene

MalaCards: The human disease database

(1) MalaCards diseases for IKBKE Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
rabies
  • lyssa
- elite association - COSMIC cancer census association via MalaCards
Search IKBKE in MalaCards View complete list of genes associated with diseases

Relevant External Links for IKBKE

Genetic Association Database (GAD)
IKBKE
Human Genome Epidemiology (HuGE) Navigator
IKBKE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IKBKE
genes like me logo Genes that share disorders with IKBKE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IKBKE Gene

Publications for IKBKE Gene

  1. SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death. (PMID: 20188669) Renner F … Schmitz ML (Molecular cell 2010) 3 4 22 60
  2. SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. (PMID: 16281057) Huang J … Shu HB (The EMBO journal 2005) 3 4 22 60
  3. IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex. (PMID: 10882136) Peters RT … Maniatis T (Molecular cell 2000) 2 3 4 60
  4. IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. (PMID: 10421793) Shimada T … Akira S (International immunology 1999) 2 3 4 60
  5. Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response. (PMID: 24882218) Rajsbaum R … García-Sastre A (Immunity 2014) 3 4 60

Products for IKBKE Gene

  • Addgene plasmids for IKBKE

Sources for IKBKE Gene

Content
Loading form....