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IKBKB Gene

protein-coding GIFtS: 69

GC08P042247

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.11.10 ^³
FLJ40509 ^²
IKK-B ^³
IKK-beta ^¹, ², ³
IKK2 ^¹, ², ³
IKKB ^¹, ², ³
IkBKB ^³
MGC131801 ^²
NFKBIKB ^¹, ², ³, ⁵

Descriptions
I-kappa-B kinase 2 ^³
I-kappa-B-kinase beta ^³
Nuclear factor NF-kappa-B inhibitor kinase beta ^², ³
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta ^²
inhibitor of nuclear factor kappa B kinase beta subunit ^²

External Ids
HGNC: 5960¹
Entrez Gene: 3551²
UniProtKB: O14920³
Ensembl: ENSG00000104365⁷

Search outside databases for aliases for IKBKB gene

Previous GC identifers: GC08M041757 GC08P042157 GC08P041869 GC08P042146

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IKBKB:

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB

(MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins

(NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the

cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM

600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing

activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and

binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC

3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by

OMIM]

UniProtKB/Swiss-Prot: IKKB_HUMAN, O14920

Function: Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and

phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the

inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates

NCOA3

Gene Wiki entry for IKBKB (IKK2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IKBKB gene

Entrez Gene cytogenetic band: 8p11.2 Ensembl cytogenetic band: 8p11.21 HGNC cytogenetic band: 8p11.2

IKBKB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P042247: (about GC identifiers)

Start:	42,247,986 bp from pter
End:	42,309,122 bp from pter
Size:	61,137 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000008.9 NT_007995.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IKKB_HUMAN, O14920 (See protein sequence)

Recommended Name: Inhibitor of nuclear factor kappa-B kinase subunit beta

Size: 756 amino acids; 86564 Da

Subunit: Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG;

probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK

core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome

holo-complex. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Part

of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14.

Interacts with SQSTM1 through PRKCZ or PRKCI. Forms an NGF-induced complex with IKBKB, PRKCI and

TRAF6. May interact with MAVS/IPS1. Interacts with NALP2. Interacts with TICAM1. Interacts with

Yersinia yopJ. Interacts with FAF1; the interaction disrupts the IKK complex formation. Interacts

with ATM. Part of a ternary complex consisting of TANK, IKBKB and IKBKG. Interacts with NIBP; the

interaction is direct

Subcellular location: Cytoplasm

PDB structure from and Proteopedia :

3BRT (3D)

3BRV (3D)

Secondary accessions: O75327

Post-translational modifications:

Upon cytokine stimulation, phosphorylated on Ser-177 and Ser-181 by MEKK1 and/or MAP3K14/NIK; which

enhances activity. Once activated, autophosphorylates on the C-terminal serine cluster; which

decreases activity and prevents prolonged activation of the inflammatory response¹

Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, which

blocks the I-kappa-B signaling pathway¹

Ubiquitination on 'Ser-163' modulates phosphorylation on C-terminal serine residues¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001547.1

ENSEMBL proteins:

ENSP00000369030 ENSP00000339151

Human Recombinant Proteins

	Invitrogen human recombinant proteins for IKBKB
	Millipore Purified and/or Recombinant IKBKB Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IKK beta, IKK alpha + IKK beta)
	Human Recombinant Proteins from Abnova (IKBKB)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	EXP	9744859 10723127

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Antibodies for IKBKB:

	Invitrogen Antibodies for IKBKB
	Millipore Mono- and Polyclonal Antibodies for the study of IKBKB
	Sigma-Aldrich Antibodies for IKBKB
	R&D Systems Antibodies for IKBKB (IKK beta)
	Cell Signaling Technology (CST) Antibodies for IKBKB (IKKb)
	Antibodies from Abcam (IKK beta, IKK alpha + IKK beta), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IKBKB)
	Novus Biologicals Antibodies for IKBKB

Assays for IKBKB:

	Invitrogen Assays for IKBKB
	Millipore Kits and Assays for the Analysis of IKBKB
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O14920

ProtoNet protein and cluster: O14920

1 Blocks protein family: IPB000626 Ubiquitin domain

UniProtKB/Swiss-Prot: IKKB_HUMAN, O14920

Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B

kinase subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IKBKB)
		Millipore RNAi Products for the Analysis of IKBKB Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (IKBKB)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001556

Applied Biosystems Silencer® siRNAs for IKBKB

Sigma-Aldrich siRNA and siRNA Panels for IKBKB

Sigma-Aldrich shRNA Panels and shRNA for IKBKB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IKBKB
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001556
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001556
untagged cDNA clones in CMV expression vector (see all 2): NM_001556

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001556

UniProtKB/Swiss-Prot: IKKB_HUMAN, O14920

Function: Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and

phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the

inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates

NCOA3

Catalytic activity: ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein]

Enzyme Number (IUBMB): EC 2.7.11.10

Genatlas biochemistry entry for IKBKB:

inhibitor of kappa light polypeptide enhancer in B cells,kinase beta,complexing with IKBKA

15/18 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Ikbkb) (see all 18 ):

	cellular	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	liver/biliary system	muscle

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0008384	IkappaB kinase activity	IEA	--
GO:0016563	transcription activator activity	NAS	9346484 9346485 9813230
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/39 Sigma-Aldrich "Your Favorite Gene" Pathways for IKBKB (Your Favorite Gene powered by Ingenuity) (see all 39 )

PPAR Signaling
Role of PKR in Interferon Induction and Antiviral Response
Chronic Myeloid Leukemia Signaling
Hepatic Cholestasis
Acute Phase Response Signaling

GeneDecks IKBKB for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for IKBKB

5/182 Interacting proteins for IKBKB (O14920^{1, 2} ENSP00000339151³) via UniProtKB, MINT, and/or STRING (see all 182 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NFKB2	Q00653², ENSP00000337001³	MINT-48728 MINT-48594 MINT-47899 STRING (score=.998)
CDC37	Q16543², ENSP00000222005³	MINT-47956 MINT-48072 STRING (score=.902)
NFKBIB	Q15653², ENSP00000312988³	MINT-47854 STRING (score=.999)
RELA	Q04206², ENSP00000311508³	MINT-50167 STRING (score=.999)
MAP3K7	O43318², ENSP00000358335³	MINT-4652778 STRING (score=.996)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001782	B cell homeostasis	IEA	--
GO:0006464	protein modification process	IEA	--
GO:0006468	protein amino acid phosphorylation	NAS	9346484
GO:0051092	positive regulation of NF-kappaB transcription factor activity	IDA	15790681

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for IKBKB

Sigma-Aldrich Small Molecules for IKBKB:

Inhibitor

Compounds for IKBKB available from Tocris Bioscience

Compound	Action	CAS number
SC 514	IKK-2 inhibitor; attenuates NF-kappaB-induced gene expression	[354812-17-2]
TPCA-1	Potent, selective inhibitor of IKK-2	[507475-17-4]
IMD 0354	Inhibitor of IKK-2	[978-62-1]

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10/25 Novoseek chemical compound relationships for IKBKB gene (see all 25 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tab-1	74.03	6	10187861 (2), 18316610 (2), 17439942 (1), 17673602 (1)
sp 600125	40.27	2	16896943 (1), 19097143 (1)
12-o-tetradecanoylphorbol 13-acetate	33.17	6	11054378 (1), 12707358 (1), 18234971 (1), 12645577 (1) (see all 5)
threonine	31.59	3	11337492 (1), 9804849 (1), 11297557 (1)
leucine	30.26	8	9346241 (2), 12459277 (1), 11359906 (1), 12890679 (1) (see all 6)
pd 98,059	29.07	1	15821443 (1)
phosphatidylinositol	27.56	3	14585846 (2), 11279241 (1)
rantes	26.45	2	12917470 (1), 16687566 (1)
phosphoinositide	22.64	1	11389085 (1)
tyrosine	15.80	11	12707358 (2), 11093788 (2), 11483407 (2), 12645577 (2) (see all 7)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IKBKB)
		Millipore RNAi Products for the Analysis of IKBKB Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (IKBKB)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001556

Sigma-Aldrich siRNA and siRNA Panels for IKBKB

Sigma-Aldrich shRNA Panels and shRNA for IKBKB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001556

REFSEQ mRNAs for IKBKB gene:

NM_001556.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001556

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001556
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001556
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001556

Additional cDNA sequence:

AB209090.1 AF029684.1 AF031416.1 AF080158.1 AK023193.1 AK091090.1 AK091297.1 AK093537.1

AK095687.1 AK097828.1 AK290952.1 AK298241.1 AK302723.1 AK303294.1 AK303528.1 AK309052.1

AK316418.1 BC006231.2 BC090865.1 BC108694.1 BC127663.1 BC141978.1 BC144080.1 BX648165.1

CR607076.1 CR623637.1

21 DOTS entries:

DT.100027604 DT.99972055 DT.100791549 DT.455185 DT.40109373 DT.95129544 DT.75182159 DT.100791546

DT.432043 DT.95111224 DT.92009888 DT.100734046 DT.121483438 DT.92414557 DT.75122049 DT.91703816

DT.99940339 DT.121483354 DT.121483433 DT.91860992 DT.91926378

24/210 AceView cDNA sequences (see all 210 ):

AW194527 CR623637 BU857051 AW611888 CA306506 BQ006314 CA308037 BC006231

AI453201 AI264203 CD251031 BQ059522 AI536653 AF080158 AI823943 AW449114

BU732786 AA938658 BQ050714 BM769773 BX097180 BE384533 CD243765 BP431007

highest scoring ESTs for IKBKB:

AA128021 AI453201 AI699170 AJ714702 BM463333 CK821474 AA521493 AF031416 AI379342 N21119

Unigene Cluster for IKBKB:

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

Hs.597664 [show with all ESTs]

Unigene Representative Sequence: AB209090

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IKBKB (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17a	·	17b	·	17c	^	18	^	19	^	20a	·
SP1:							-																-								-										-		-
SP2:																							-								-								-		-		-
SP3:							-				-		-		-		-		-		-		-								-										-		-
SP4:							-																-
SP5:							-

ExUns:	20b	^	21	^	22a	·	22b	^	23a	·	23b	·	23c
SP1:							-
SP2:							-
SP3:							-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for IKBKB

2 Ensembl transcripts including schematic representations:

ENST00000379708 ENST00000342222

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IKBKB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IKBKB

¹ / ² / ³

11 probe-sets matching IKBKB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35960_at²^{, 3}	U95-A	1	1.00	1.00	0.82	0.75	AF031416	0.80	0.80	0.80	1
65461_r_at²^{, 3}	U95-C	1	1.00	1.00	0.83	0.79	N21119	0.80	0.80	0.80	1
54679_g_at²^{, 3}	U95-B	1	1.00	1.00	0.97	1.21	AA521493	0.80	0.80	0.80	1
54675_at²^{, 3}	U95-B	1	1.00	1.00	0.93	1.33	AA521493	0.80	0.80	0.80	1
44812_at²^{, 3}	U95-B	1	0.56	1.00	0.96	0.92	AI379342	0.80	0.80	0.80	1
209342_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF080158	0.60	0.75	0.68	1
209341_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AU153366	0.60	0.75	0.68	1
211027_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC006231	0.40	0.67	0.55	1
209342_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209341_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211027_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks IKBKB for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.597664
Expression variation in blood from EXPOLDB for IKBKB
UniProtKB/Swiss-Prot: IKKB_HUMAN, O14920
Tissue specificity: Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen,
thymus, prostate, testis and peripheral blood

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IKBKB gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IKBKB¹	--	inhibitor of kappa light polypeptide gene enhancer more	90.11(n) 95.1(a)	482839 XM_539954.2 XP_539954.2
chimpanzee (Pan troglodytes)	IKBKB¹	--	inhibitor of kappa light polypeptide gene enhancer more	97.88(n) 97.62(a)	472749 XM_528121.2 XP_528121.2
cow (Bos taurus)	IKBKB¹	--	inhibitor of kappa light polypeptide gene enhancer more	86.55(n) 93.25(a)	281854 NM_174353.2 NP_776778.1
rat (Rattus norvegicus)	Ikbkb¹	--	inhibitor of kappaB kinase beta	87.11(n) 91.52(a)	84351 NM_053355.1 NP_445807.1
mouse (Mus musculus)	Ikbkb^{1, 5}	8⁵	inhibitor of kappaB kinase beta^{1, 5}	87.35(n)¹ 93.33(a)¹	16150¹ NM_010546.1¹ NP_034676.1¹ AA203913⁵ AF026524⁵ (see all 36)

About this table Species with no ortholog for IKBKB

ENSEMBL Gene Tree for IKBKB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IKBKB gene

IKBKE² CHUK² TBK1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/321 NCBI SNPs in IKBKB are shown (see all 321 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 133)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs9298621^1,2	C,F,H	42246610(+)	`CTGTTT/CTCAAT`	1	--	ng5¹ tfbs³		4		EU EA WA	418
	rs2272736^1,2	C,F,H	42296320(+)	`TGGGCG/AGGTAG`	1	Q/R	mis¹ ese³		9		EA EU WA	2274
	rs1057741^1,2	A,C,F	42307707(+)	`TGTGCG/AGTGGG`	1	--	ut3¹		5		NA NS	232
--	rs10108113^1,2	C,H	42308597(+)	`TATATT/CTTGTA`	1	--	ut3¹		3		EU EA	298
--	rs13270719^1,2	A	42309621(+)	`tgagcA/Cgagat`	1	--	ng3¹		0	--	--	--	--
--	rs13278231^1,2	A	42309597(+)	`gaaccC/Taggag`	1	--	ng3¹		0	--	--	--	--
--	rs13270698^1,2	A	42309598(+)	`aacctA/Gggagg`	1	--	ng3¹		0	--	--	--	--
	rs6991366^1,2	H	42270175(+)	`CCTTGC/ATGAGT`	1	M/L	mis¹		4		EU EA WA	418
	rs7825781^1,2	H	42246813(+)	`CCCGGG/CAACCA`	1	--	ng5¹		4		EU EA WA	398
--	rs17611716^1,2	H	42307589(+)	`TTCAGG/ACCCTA`	1	T/A	mis¹		7		NA EU EA WA	548

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HapMap Linkage Disequilibrium images for IKBKB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 603258

10/30 Novoseek disease relationships for IKBKB gene (see all 30 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	70.56	39	11054378 (2), 9710600 (1), 16085647 (1), 9346485 (1) (see all 33)
leukemia t-cell	59.29	2	9632633 (1), 10648602 (1)
tumors	55.84	54	11054378 (2), 15492250 (2), 9710600 (1), 15084260 (1) (see all 41)
inflammation	51.48	22	16517756 (3), 15731493 (2), 16002568 (2), 14704736 (1) (see all 15)
cancer	40.19	13	15617879 (2), 18702457 (2), 11520600 (1), 18037881 (1) (see all 9)
insulin resistance	31.63	14	18240344 (3), 15617879 (2), 15351728 (2), 12021247 (1) (see all 8)
rheumatoid arthritis	22.48	7	12847684 (2), 11160335 (1), 15316093 (1), 17067557 (1)
shock	20.14	3	18282612 (1), 16309849 (1), 16424045 (1)
bacterial infections	10.94	1	9819420 (1)
breast cancer	10.47	8	17016640 (2), 15084260 (1), 16357145 (1), 11325857 (1) (see all 7)

About this table

Genetic Association Database: IKBKB
Human Genome Epidemiology Navigator: IKBKB (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

100/472 PubMed articles for IKBKB gene (see all 472 ):

Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization. (PubMed id 9763654)^{2, 3, 4} Shindo M.... Okumura K. (1998)
Site-specific monoubiquitination of IkappaB kinase IKKbeta regulates its phosphorylation and persistent activation. (PubMed id 16267042)^{1, 3, 4} Carter R.S....Ballard D.W. (2005)
IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes. (PubMed id 9813230)^{1, 3, 4} Hu M.C.-T. and Wang Y.-P. (1998)
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. (PubMed id 10195894)^{1, 3, 4} Delhase M.... Karin M. (1999)
FAF1 suppresses IkappaB kinase (IKK) activation by disrupting the IKK complex assembly. (PubMed id 17684021)^{1, 3, 4} Park M.Y....Kim E. (2007)
NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF- (kappa)B activation. (PubMed id 15951441)^{1, 3, 4} Hu W.H.... Bethea J.R. (2005)
Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase. (PubMed id 9819420)^{1, 3, 4} Nemoto S.... Lin A. (1998)
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. (PubMed id 9346485)^{1, 3, 4} Woronicz J.D.... Goeddel D.V. (1997)
The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. (PubMed id 10356400)^{1, 3, 4} Sanz L.... Moscat J. (1999)
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF- kappaB activation. (PubMed id 9346484)^{1, 3, 4} Mercurio F.... Rao A. (1997)
Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. (PubMed id 12133833)^{3, 4} Chariot A.... Siebenlist U. (2002)
Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected]. (PubMed id 12890679)^{1, 3} Tang E.D....Guan K.L. (2003)
Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen. (PubMed id 19104039)^{1, 3} Lam L.T....Staudt L.M. (2008)
NEMO binding domain of IKK-2 encompasses amino acids 735-745. (PubMed id 16583354)^{1, 3} Strnad J....Burke J.R. (2006)
Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification. (PubMed id 19202066)^{1, 3} Kawauchi K....Tanaka N. (2009)
Differential requirements for IKKalpha and IKKbeta in the differentiation of primary human osteoarthritic chondrocytes. (PubMed id 18163512)^{1, 3} Olivotto E....Marcu K.B. (2008)
High-affinity interaction between IKKbeta and NEMO. (PubMed id 18266324)^{1, 3} Lo Y.C....Wu H. (2008)
Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers. (PubMed id 17016640)^{1, 3} Ping B....Hung M.C. (2006)
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. (PubMed id 9346241)^{1, 3} Zandi E....Karin M. (1997)
Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells. (PubMed id 18408758)^{1, 3} Chen R....Mor G. (2008)
IKK-2 is required for TNF-alpha-induced invasion and proliferation of human mesenchymal stem cells. (PubMed id 18600306)^{1, 3} BAPcker W....Schieker M. (2008)
c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression. (PubMed id 12645577)^{1, 3} Huang W.C....Chen C.C. (2003)
Endothelial IKK beta signaling is required for monocyte adhesion under laminar flow conditions. (PubMed id 11945026)^{1, 3} Meiler S.E....Rosenzweig A. (2002)
IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity. (PubMed id 10779355)^{1, 3} Yamamoto Y....Gaynor R.B. (2000)
IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. (PubMed id 9891086)^{1, 3} Mercurio F.... Manning A.M. (1999)
Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. (PubMed id 9721103)^{1, 3} Zandi E....Karin M. (1998)
IkappaB kinase beta (IKKbeta/IKK2/IKBKB)--a key molecule in signaling to the transcription factor NF-kappaB. (PubMed id 18308615)^{1, 3} Schmid J.A. and Birbach A. (2008)
Nickel compounds render anti-apoptotic effect to human bronchial epithelial Beas-2B cells by induction of cyclooxygenase-2 through an IKKbeta/p65-dependent and IKKalpha- and p50-independent pathway. (PubMed id 16982623)^{1, 3} Ding J....Huang C. (2006)
Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells. (PubMed id 15856023)^{1, 3} Xu C....Kong A.N. (2005)
Detection of IKKbeta-IKKgamma subcomplexes in monocytic cells and characterization of associated signaling. (PubMed id 15226300)^{1, 3} Quirling M....Brand K. (2004)
IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf. (PubMed id 12589056)^{1, 3} Albanese C....Pestell R.G. (2003)
Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation. (PubMed id 12612076)^{1, 4} Tegethoff S....Scheidereit C. (2003)
Kinetic mechanisms of IkappaB-related kinases (IKK) inducible IKK and TBK-1 differ from IKK-1/IKK-2 heterodimer. (PubMed id 11815618)^{1, 3} Huynh Q.K....Tripp C.S. (2002)
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. (PubMed id 9751060)^{1, 3} Rothwarf D.M.... Karin M. (1998)
IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. (PubMed id 17693255)^{1, 3} Lee D.F....Hung M.C. (2007)
Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription. (PubMed id 15489227)^{1, 3} Buss H....Kracht M. (2004)
IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2. (PubMed id 11839743)^{1, 3} Kishore N.... Tripp C.S. (2002)
The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF. (PubMed id 11359906)^{1, 3} Devin A....Liu Zg . (2001)
Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. (PubMed id 10755617)^{1, 3} Zhang S.Q....Wallach D. (2000)
PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination. (PubMed id 19150425)³ Li S....Dorf M.E. (2009)
Platonin inhibits LPS-induced NF-kappaB by preventing activation of Akt and IKKbeta in human PBMC. (PubMed id 19109741)³ Shao D.Z. and Lin M. (2008)
Interleukin-1beta up-regulates RGS4 through the canonical IKK2/IkappaBalpha/NF-kappaB pathway in rabbit colonic smooth muscle. (PubMed id 18260825)³ Hu W....Murthy K.S. (2008)
Blockage of NF-kappaB by IKKbeta- or RelA-siRNA rather than the NF-kappaB super-suppressor IkappaBalpha mutant potentiates adriamycin-induced cytotoxicity in lung cancer cells. (PubMed id 18636537)³ Chen W....Lin Y. (2008)
S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. (PubMed id 18952604)³ Zhang J....Ye J. (2008)
Atypical protein kinase C phosphorylates IKKalphabeta in transformed non-malignant and malignant prostate cell survival. (PubMed id 18571841)³ Win H.Y. and Acevedo-Duncan M. (2008)
The human IKKbeta subunit kinase domain displays CK2-like phosphorylation specificity. (PubMed id 18657515)³ Shaul J.D....Huxford T. (2008)
A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae. (PubMed id 17237423)³ Ha U....Li J.D. (2007)
Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways. (PubMed id 17466952)³ Verhaeghe C....Bours V. (2007)
Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta. (PubMed id 17244613)³ Solt L.A....May M.J. (2007)
Activation of the virus-induced IKK/NF-kappaB signalling axis is critical for the replication of human cytomegalovirus in quiescent cells. (PubMed id 17419715)³ Caposio P....Gribaudo G. (2007)
Loss of Ikkbeta promotes migration and proliferation of mouse embryo fibroblast cells. (PubMed id 16966325)³ Chen F....Karin M. (2006)
Theileria-induced constitutive IKK activation is independent of functional Hsp90. (PubMed id 16938294)³ Hermann P. and Dobbelaere D.A. (2006)
Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179. (PubMed id 16998237)³ Ahmad R....Kufe D. (2006)
3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling. (PubMed id 16207722)³ Tanaka H....Tsuruo T. (2005)
Dendritic cells genetically engineered with adenoviral vector encoding dnIKK2 induce the formation of potent CD4+ T-regulatory cells. (PubMed id 15880043)³ Tomasoni S....Benigni A. (2005)
Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex. (PubMed id 15749833)³ Funakoshi-Tago M....Kasahara T. (2005)
Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation. (PubMed id 15808510)³ Park K.J....Gaynor R.B. (2005)
IKKbeta phosphorylates p65 at S468 in transactivaton domain 2. (PubMed id 16046471)³ Schwabe R.F. and Sakurai H. (2005)
Human cytomegalovirus stimulates cellular IKK2 activity and requires the enzyme for productive replication. (PubMed id 14990741)³ Caposio P....Landolfo S. (2004)
Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation. (PubMed id 15140882)³ Xiao G....Sun S.C. (2004)
Transcriptional profiling of IKK2/NF-kappa B- and p38 MAP kinase-dependent gene expression in TNF-alpha-stimulated primary human endothelial cells. (PubMed id 14715628)³ Viemann D....Roth J. (2004)
TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. (PubMed id 15492226)³ Ea C.K....Chen Z.J. (2004)
In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase. (PubMed id 12657630)³ Carter R.S.... Ballard D.W. (2003)
Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway. (PubMed id 12842894)³ Sakurai H....Saiki I. (2003)
TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. (PubMed id 11864612)³ Chen G....Goeddel D.V. (2002)
Genetic variability in insulin action inhibitor Ikkbeta (IKBKB) does not play a major role in the development of type 2 diabetes. (PubMed id 11932336)⁶ Menzaghi C....Doria A. (2002)
Fanconi anemia protein complex is a novel target of the IKK signalsome. (PubMed id 12210728)³ Otsuki T....Liu J.M. (2002)
TAK1 is a ubiquitin-dependent kinase of MKK and IKK. (PubMed id 11460167)³ Wang C....Chen Z.J. (2001)
The physical association of protein kinase C theta with a lipid raft-associated inhibitor of kappa B factor kinase (IKK) complex plays a role in the activation of the NF-kappa B cascade by TCR and CD28. (PubMed id 11120819)³ Khoshnan A....Nel A.E. (2000)
A novel, highly selective, tight binding IkappaB kinase-2 (IKK-2) inhibitor: a tool to correlate IKK-2 activity to the fate and functions of the components of the nuclear factor-kappaB pathway in arthritis-relevant cells and animal models. (PubMed id 19168710)¹ Mbalaviele G....Kishore N. (2009)
Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions. (PubMed id 10648602)¹ O'Mahony A....Greene W.C. (2000)
An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation. (PubMed id 18490491)¹ Fong C.H....Lawrence T. (2008)
Peptides corresponding to the N and C termini of IkappaB-alpha, -beta, and -epsilon as probes of the two catalytic subunits of IkappaB kinase, IKK-1 and IKK-2. (PubMed id 10593898)¹ Burke J.R....Meyers C.A. (1999)
IkappaB kinase-2-independent and -dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic. (PubMed id 16517756)¹ Birrell M.A....Belvisi M.G. (2006)
Validation of IKK beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK beta to pulmonary epithelial cells. (PubMed id 15723090)¹ Catley M.C....Newton R. (2005)
IKK beta is required for Bcl-2-mediated NF-kappa B activation in ventricular myocytes. (PubMed id 12167626)¹ Regula K.M....Kirshenbaum L.A. (2002)
Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases. (PubMed id 9710600)¹ Geleziunas R....Greene W.C. (1998)
PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. (PubMed id 18930133)¹ Sun W....Yang J. (2009)
Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta. (PubMed id 15731493)¹ Kim F....Raines E.W. (2005)
[Preliminary study of inhibition of human Tenon's capsule fibroblasts in vitro by RNA interference targeting IKK-beta] (PubMed id 16409758)¹ Huang S.S....Ma P. (2005)
Characterization of the bovine IkappaB kinases (IKK)alpha and IKKbeta, the regulatory subunit NEMO and their substrate IkappaBalpha. (PubMed id 12459277)¹ Rottenberg S....Dobbelaere D.A. (2002)
Cationic nano-copolymers mediated IKKbeta targeting siRNA inhibit the proliferation of human Tenon's capsule fibroblasts in vitro. (PubMed id 19137061)¹ Duan Y....Shao T. (2008)
IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver. (PubMed id 18606991)¹ Luedde T....Pasparakis M. (2008)
Synthesis and structure activity relationship studies of benzothieno[3,2-b]furan derivatives as a novel class of IKKbeta inhibitors. (PubMed id 17409557)¹ Sugiyama H....Ikeura Y. (2007)
IKKalpha regulates the mitotic phase of the cell cycle by modulating Aurora A phosphorylation. (PubMed id 17102620)¹ Prajapati S....Gaynor R.B. (2006)
IKK alpha regulates estrogen-induced cell cycle progression by modulating E2F1 expression. (PubMed id 16407216)¹ Tu Z....Gaynor R.B. (2006)
A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. (PubMed id 12813046)¹ Kishore N....Tripp C.S. (2003)
Role of ikkgamma/nemo in assembly of the IkappaB kinase complex. (PubMed id 11080499)¹ Li X.-H.... Gaynor R.B. (2001)
The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component. (PubMed id 10893415)¹ Krappmann D....Scheidereit C. (2000)
Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells. (PubMed id 9804806)¹ O'Connell M.A....Mackman N. (1998)
IKKbeta and the anti-adipogenic effect of platelet-derived growth factor in human abdominal subcutaneous preadipocytes. (PubMed id 19141566)¹ Gagnon A....Sorisky A. (2009)
Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta. (PubMed id 18240344)¹ Yi P....Wang K.F. (2008)
Bridging the gap between in silico and cell-based analysis of the nuclear factor-kappaB signaling pathway by in vitro studies of IKK2. (PubMed id 17313484)¹ Ihekwaba A.E....Benson N. (2007)
Rosmarinic acid as a downstream inhibitor of IKK-beta in TNF-alpha-induced upregulation of CCL11 and CCR3. (PubMed id 16604092)¹ Lee J....Kim Y.S. (2006)
Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle. (PubMed id 16687566)¹ Catley M.C....Newton R. (2006)
FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses. (PubMed id 16413924)¹ Victoratos P....Kollias G. (2006)
Regulation and function of IKK and IKK-related kinases. (PubMed id 17047224)¹ Hacker H. and Karin M. (2006)
IKK2 inhibitor alleviates kidney and wasting diseases in a murine model of human AIDS. (PubMed id 15039214)¹ Heckmann A....Sagot Y. (2004)
Mature T cells depend on signaling through the IKK complex. (PubMed id 14499113)¹ Schmidt-Supprian M....Pasparakis M. (2003)
Blocking caspase-3-mediated proteolysis of IKKbeta suppresses TNF-alpha-induced apoptosis. (PubMed id 11741536)¹ Tang G....Lin A. (2001)

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Entrez Gene: 3551	HGNC: 5960	AceView: IKBKB	Ensembl:ENSG00000104365	euGenes: HUgn3551
ECgene: IKBKB	H-InvDB: IKBKB

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IKBKB Gene

protein-coding GIFtS: 69

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IKBKB Gene

protein-coding GIFtS: 69

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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