Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



IKBKB Gene

protein-coding   GIFtS: 72
GCID: GC08P042146

Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells,...

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase
Beta1 2
     I-Kappa-B Kinase 22 3
NFKBIKB2 3 5     I-Kappa-B-Kinase Beta2 3
Nuclear Factor NF-Kappa-B Inhibitor Kinase Beta2 3     EC 2.7.11.103 8
IKK-B2 3     IMD152 5
IKK-beta2 3     Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Beta2
IKK22 3     IkBKB3
IKKB2 3     EC 2.7.118

External Ids:    HGNC: 59601   Entrez Gene: 35512   Ensembl: ENSG000001043657   OMIM: 6032585   UniProtKB: O149203   

Export aliases for IKBKB gene to outside databases

Previous GC identifers: GC08M041757 GC08P042157 GC08P041869 GC08P042247 GC08P040656


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for IKBKB Gene:
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing
dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of
proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. (provided
by RefSeq, Sep 2011)

GeneCards Summary for IKBKB Gene:
IKBKB (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta) is a protein-coding gene. Diseases associated with IKBKB include immunodeficiency 15, and shigellosis. GO annotations related to this gene include protein heterodimerization activity and protein homodimerization activity. An important paralog of this gene is IKBKE.

UniProtKB/Swiss-Prot: IKKB_HUMAN, O14920
Function: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by
multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular
stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and
phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow
polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is
translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response,
growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several
other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as
IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of
inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other
substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation
in UV-induced NF-kappa-B activation

summary for IKBKB Gene:
IkappaB Kinase (IKK) is an enzyme complex that forms part of the NF-kappaB signaling pathway. The complex is
comprised of three subunits (IKKalpha (IKK1), IKKbeta (IKK2) and IKKgamma (NEMO)), the alpha- and
beta-subunits are catalytically active whereas the gamma-subunit serves a regulatory function. Activation of
NF-kappaB occurs via degradation of IkappaB, a process that is initiated by its phosphorylation by IkappaB
kinase (IKK). Phosphorylated IkappaB becomes dissociated from NF-kappaB, unmasking the NLS. Phosphorylation
also results in IkappaB ubiquitination and targeting to the proteasome. NF-kappaB can now enter the nucleus
and regulate gene expression.

Gene Wiki entry for IKBKB (IKK2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IKBKB gene promoter:
         Max1   ER-alpha   C/EBPbeta   STAT1   p53   RREB-1   HTF   POU3F2   C/EBPalpha   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIKBKB promoter sequence
   Search Chromatin IP Primers for IKBKB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IKBKB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.2   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p11.2

IKBKB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IKBKB gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P042146:  view genomic region     (about GC identifiers)

Start:
42,128,820 bp from pter      End:
42,190,171 bp from pter
Size:
61,352 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: IKKB_HUMAN, O14920 (See protein sequence)
Recommended Name: Inhibitor of nuclear factor kappa-B kinase subunit beta  
Size: 756 amino acids; 86564 Da
Subunit: Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four
alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to
associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. The IKK complex associates
with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65. Part of a complex composed of
NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Part of a 70-90 kDa complex at least consisting of CHUK/IKKA,
IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Found in a membrane raft complex, at least composed of BCL10, CARD11,
DPP4 and IKBKB. Interacts with SQSTM1 through PRKCZ or PRKCI. Forms an NGF-induced complex with IKBKB, PRKCI and
TRAF6. May interact with MAVS/IPS1. Interacts with NALP2. Interacts with TICAM1. Interacts with Yersinia yopJ.
Interacts with FAF1; the interaction disrupts the IKK complex formation. Interacts with ATM. Part of a ternary
complex consisting of TANK, IKBKB and IKBKG. Interacts with NIBP; the interaction is direct. Interacts with ARRB1
and ARRB2. Interacts with TRIM21. Interacts with NLRC5; prevents IKBKB phosphorylation and kinase activity.
Interacts with PDPK1. Interacts with EIF2AK2/PKR. The phosphorylated form interacts with PPM1A and PPM1B.
Interacts with ZNF268 isoform 2; the interaction is further increased in a TNF-alpha-dependent manner. Interacts
with IKBKE
4 PDB 3D structures from and Proteopedia for IKBKB:
3BRT (3D)        3BRV (3D)        4E3C (3D)        4KIK (3D)    
Secondary accessions: B4DZ30 B4E0U4 O75327
Alternative splicing: 4 isoforms:  O14920-1   O14920-2   O14920-3   O14920-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IKBKB: NX_O14920

Explore proteomics data for IKBKB at MOPED

Post-translational modifications: 

  • Upon cytokine stimulation, phosphorylated on Ser-177 and Ser-181 by MEKK1 and/or MAP3K14/NIK as well as TBK1 and
    PRKCZ; which enhances activity. Once activated, autophosphorylates on the C-terminal serine cluster; which
    decreases activity and prevents prolonged activation of the inflammatory response. Phosphorylated by the
    IKK-related kinases TBK1 and IKBKE, which is associated with reduced CHUK/IKKA and IKBKB activity and
    NF-kappa-B-dependent gene transcription. Dephosphorylated at Ser-177 and Ser-181 by PPM1A and PPM1B1
  • Acetylation of Thr-180 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the I-kappa-B
    pathway1
  • Ubiquitinated. Monoubiquitination involves TRIM21 that leads to inhibition of Tax-induced NF-kappa-B signaling.
    According to PubMed:19675099, 'Ser-163' does not serve as a monoubiquitination site. According to
    PubMed:16267042, ubiquitination on 'Ser-163' modulates phosphorylation on C-terminal serine residues.
    Monoubiquitination by TRIM21 is disrupted by Yersinia yopJ1
  • Hydroxylated by PHD1/EGLN2, loss of hydroxylation under hypoxic conditions results in activation of NF-kappaB1
  • Ubiquitination2 at Lys106, Lys163, Lys555
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for IKBKB (O14920) (see all 11)
     QGQRAAM  RDLKPEN  QQLKAKL  PLLAMEYC 


    See IKBKB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001177649.1  NP_001229707.1  NP_001547.1  

    ENSEMBL proteins: 
     ENSP00000430684   ENSP00000429699   ENSP00000428799   ENSP00000429319   ENSP00000430483  
     ENSP00000429239   ENSP00000430868   ENSP00000430557   ENSP00000339151   ENSP00000427978  
     ENSP00000429924   ENSP00000428186   ENSP00000428922   ENSP00000429357   ENSP00000428892  
     ENSP00000430114   ENSP00000404920   ENSP00000369030  
    Reactome Protein details: O14920

    IKBKB Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant IKBKB Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for IKBKB
    OriGene Protein Over-expression Lysate for IKBKB
    OriGene MassSpec for IKBKB
    OriGene Custom Protein Services for IKBKB
    GenScript Custom Purified and Recombinant Proteins Services for IKBKB
    Novus Biologicals IKBKB Proteins
    Novus Biologicals IKBKB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    IKBKB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IKBKB
    R&D Systems Antibodies for IKBKB (IKK beta)
    Cell Signaling Technology (CST) Antibodies for IKBKB  (IKKB)
    OriGene Antibodies for IKBKB
    OriGene Custom Antibody Services for IKBKB
    Novus Biologicals IKBKB Antibodies
    Abcam antibodies for IKBKB
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for IKBKB
    LSBio Antibodies in human, mouse, rat for IKBKB

    IKBKB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IKBKB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IKBKB
    Cell Signaling Technology (CST) Sandwich ELISA Kits for IKBKB (IKKB)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
    IKK family

    5 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom
     IPR000626 Ubiquitin_dom
     IPR022007 IKKbetaNEMObind

    Graphical View of Domain Structure for InterPro Entry O14920

    ProtoNet protein and cluster: O14920

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: IKKB_HUMAN, O14920
    Domain: The kinase domain is located in the N-terminal region. The leucine zipper is important to allow homo- and
    hetero-dimerization. At the C-terminal region is located the region responsible for the interaction with
    NEMO/IKBKG
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily
    Similarity: Contains 1 protein kinase domain


    IKBKB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IKKB_HUMAN, O14920
    Function: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by
    multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular
    stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and
    phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow
    polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is
    translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response,
    growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several
    other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as
    IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of
    inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other
    substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation
    in UV-induced NF-kappa-B activation
    Catalytic activity: ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein]

         Genatlas biochemistry entry for IKBKB:
    inhibitor of kappa light polypeptide enhancer in B cells,kinase beta,complexing with IKBKA

         Enzyme Numbers (IUBMB): EC 2.7.11.101 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA--
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI10521409
    GO:0005524ATP binding IEA--
         
    IKBKB for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for IKBKB:
     Decreased focal adhesion (FA)   Decreased nuclei size in G2M  Decreased substrate adherent c  Decreased viability 
     Decreased viability with pacli  Increased circadian period len  Synthetic lethal with Ras 

         15 MGI mutant phenotypes (inferred from 11 alleles(MGI details for Ikbkb):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  limbs/digits/tail 
     liver/biliary system  mortality/aging  muscle  nervous system  normal 

    IKBKB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IKBKB: Ikbkbtm1Ver Ikbkbtm2.1Cgn Ikbkbtm1.1Cgn Ikbkbtm1Mka Ikbkbtm2.1Mka Ikbkbtm1Trk

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IKBKB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IKBKB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IKBKB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IKBKB

    miRNA
    Products:
        
    miRTarBase miRNAs that target IKBKB:
    hsa-mir-200c-3p (MIRT006884), hsa-mir-199a-5p (MIRT003828), hsa-mir-218-5p (MIRT004030), hsa-mir-151a-3p (MIRT043610), hsa-mir-335-5p (MIRT018148)

    Block miRNA regulation of human, mouse, rat IKBKB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IKBKB (see all 21):
    hsa-miR-429 hsa-miR-15a hsa-miR-503 hsa-miR-3125 hsa-miR-3916 hsa-miR-515-5p hsa-miR-424 hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidIKBKB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IKBKB
    Predesigned siRNA for gene silencing in human, mouse, rat IKBKB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IKBKB

    Clone
    Products:
         
    OriGene clones in human, mouse for IKBKB (see all 12)
    OriGene ORF clones in mouse, rat for IKBKB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): IKBKB (NM_001556)
    Sino Biological Human cDNA Clone for IKBKB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IKBKB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKBKB

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IKBKB
    Browse ESI BIO Cell Lines and PureStem Progenitors for IKBKB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKBKB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    IKKB_HUMAN, O14920: Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    plasma membrane3

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0008385IkappaB kinase complex TAS18626576
    GO:0009898cytoplasmic side of plasma membrane ISS--

    IKBKB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for IKBKB About   (see all 116)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TWEAK Pathway0.87
    Apoptotic Pathways Triggered By HIV10.42
    DR3 Signaling0.87
    Apoptosis through Death Receptors0.42
    TNFR1 Pathway0.56
    TRAIL Pathway0.40
    TNF Signaling0.55
    Fas Signaling0.35
    2NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    NOD-like Receptor Signaling Pathways0.58
    Immune response IL 1 signaling pathway0.42
    Inflammasome Activation Pathways0.51
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    IL-1 Family Signaling Pathways0.44
    3RANK Signaling in Osteoclasts
    BAFF in B-Cell Signaling0.92
    Apoptosis and survival APRIL and BAFF signaling0.39
    APRIL Pathway0.92
    RANK Pathway0.38
    RANK Signaling in Osteoclasts0.45
    RANKL/RANK Signaling Pathway0.31
    4Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.68
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.68
    NOD pathway0.33
    5Development IGF 1 receptor signaling
    Development IGF RI signaling0.49
    Development IGF 1 receptor signaling0.48
    Signal transduction AKT signaling0.49
    Immune response IL 4 signaling pathway0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for IKBKB (see all 7)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-1 Family Signaling Pathways
    IL-17 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IKBKB (see all 63)
        TWEAK Pathway
    14-3-3 Induced Apoptosis
    LT-BetaR Pathway
    Toll-Like Receptors Pathway
    Antioxidant Action of Vitamin-C

    2 Cell Signaling Technology (CST) Pathways for IKBKB
        Apoptosis and Autophagy
    NF-kappaB Signaling

    5 Tocris Bioscience Pathways for IKBKB
        Akt Pathway
    Insulin Pathway
    Apoptosis Pathway
    Toll-like Receptor Pathway
    NF-kappaB Pathway

    Selected GeneGo (Thomson Reuters) Pathways for IKBKB (see all 44)
        Development A2A receptor signaling
    Immune response Bacterial infections in normal airways
    Immune response MIF in innate immunity response
    Development EGFR signaling pathway
    Signal transduction AKT signaling

    Selected BioSystems Pathways for IKBKB (see all 34)
        Osteopontin Signaling
    MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Apoptosis
    NOD pathway


    Selected Reactome Pathways for IKBKB (see all 14)
        p75NTR recruits signalling complexes
    NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
    IRAK1 recruits IKK complex
    IKK complex recruitment mediated by RIP1
    FCERI mediated NF-kB activation


    Selected Kegg Pathways  (Kegg details for IKBKB) (see all 38):
        MAPK signaling pathway
    Ras signaling pathway
    Chemokine signaling pathway
    NF-kappa B signaling pathway
    FoxO signaling pathway


    IKBKB for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IKBKB (see all 12): 
              mTOR Signaling in human mouse rat
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IKBKB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IKBKB (O149201, 2, 3 ENSP000003391514) via UniProtKB, MINT, STRING, and/or I2D (see all 299)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001782B cell homeostasis IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006468protein phosphorylation NAS9346484

    IKBKB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for IKBKB
      Browse compounds at ApexBio 

    Compounds for IKBKB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ACHPSelective IKKalpha and IKKbeta inhibitor[406208-42-2]
    AmlexanoxInhibitor of TBK1 and IKKepsilon; antiallergic agent[68302-57-8]
    TPCA-1 Potent, selective inhibitor of IKKbeta [507475-17-4]
    IKK 16Selective inhibitor of IKK[1186195-62-9]
    PF 184Potent and selective IKKbeta inhibitor[1187460-81-6]

    3 HMDB Compounds for IKBKB    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    SumatriptanImigran (see all 4)103628-46-2--

    4 DrugBank Compounds for IKBKB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Arsenic trioxideAcide Arsenieux [French] (see all 11)1327-53-3targetinducer17450217 16387740 11752352 16230390
    Mesalazine5-aminosalicylate (see all 4)89-57-6targetinhibitor11054378 11151876 12950415
    Auranofin-- 34031-32-8targetinhibitor12754408 17034761
    SulfasalazineSulfasalazin (see all 2)599-79-1targetinhibitor11054378 12950415

    Selected Novoseek inferred chemical compound relationships for IKBKB gene (see all 57)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tab-1 72.7 6 10187861 (2), 18316610 (2), 17439942 (1), 17673602 (1)
    bortezomib 50.1 2 19436050 (1)
    serine 48.9 25 9804849 (2), 11444880 (2), 14704736 (1), 16896943 (1) (see all 22)
    parthenolide 43.6 2 10553091 (1), 15618150 (1)
    sp 600125 41.8 2 16896943 (1), 19097143 (1)
    herbimycin a 41.8 2 15155828 (2)
    geldanamycin 41.7 2 16432176 (1), 15077173 (1)
    pdtc 40.8 6 19399830 (1), 20037166 (1), 16490171 (1), 16998220 (1) (see all 5)
    sulindac 37.3 8 19526344 (5), 15033733 (1), 10480951 (1)
    salicylic acid 34.6 9 9817203 (3), 10753891 (2), 10553070 (1), 10480951 (1) (see all 6)



    IKBKB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for IKBKB gene (5 alternative transcripts): 
    NM_001190720.2  NM_001242778.1  NM_001556.2  NM_001190721.1  NM_001190722.1  

    Unigene Cluster for IKBKB:

    Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
    Hs.597664  [show with all ESTs]
    Unigene Representative Sequence: NR_033818
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000520810(uc011lco.2) ENST00000520320 ENST00000517890 ENST00000519733
    ENST00000519735 ENST00000523105 ENST00000520835 ENST00000517917 ENST00000518679
    ENST00000342222(uc003xox.2 uc010lxj.2 uc003xow.2 uc011lcp.2 uc011lcq.2 uc010lxi.2 uc011lcr.2)
    ENST00000518983 ENST00000520201(uc010lxh.2 uc022auj.1) ENST00000517388
    ENST00000518647(uc003xov.3) ENST00000521661 ENST00000520655 ENST00000517812
    ENST00000522147
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IKBKB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IKBKB (see all 21):
    hsa-miR-429 hsa-miR-15a hsa-miR-503 hsa-miR-3125 hsa-miR-3916 hsa-miR-515-5p hsa-miR-424 hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidIKBKB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IKBKB
    Predesigned siRNA for gene silencing in human, mouse, rat IKBKB
    Clone
    Products:
         
    OriGene clones in human, mouse for IKBKB (see all 12)
    OriGene ORF clones in mouse, rat for IKBKB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): IKBKB (NM_001556)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IKBKB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKBKB
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IKBKB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IKBKB
      QuantiTect SYBR Green Assays in human, mouse, rat IKBKB
      QuantiFast Probe-based Assays in human, mouse, rat IKBKB

    Additional mRNA sequence: 

    AF029684.1 AF031416.1 AF080158.1 AK091297.1 AK290952.1 AK298241.1 AK302723.1 AK303294.1 
    AK303528.1 AK316418.1 BC006231.2 BC090865.1 BC127663.1 BC141978.1 BC144080.1 HM245392.1 
    NR_033818.1 NR_033819.1 NR_040009.1 

    21 DOTS entries:

    DT.100027604  DT.99972055  DT.100791549  DT.455185  DT.95129544  DT.100791546  DT.75182159  DT.40109373 
    DT.432043  DT.95111224  DT.121483438  DT.75122049  DT.91703816  DT.99940339  DT.121483354  DT.121483433 
    DT.91860992  DT.91926378  DT.92009888  DT.92414557  DT.100734046 

    Selected AceView cDNA sequences (see all 210):

    BQ050714 AI675938 AI823943 AK095687 NM_001556 AW510331 AW449114 N22157 
    CR607076 AA807981 CA306506 AW004920 AW299768 BM974500 BM980513 AI440458 
    CA429223 BU624334 BQ006314 BQ877352 BC006231 AW611888 CB270059 BF196645 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IKBKB (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a ·
    SP1:                    -                                               -                       -                             -     -                           
    SP2:                                                                    -                       -                       -     -     -                           
    SP3:                    -           -     -     -     -     -     -     -                       -                             -     -                           
    SP4:                    -                                               -                                                                                       
    SP5:                    -                                                                                                                                       

    ExUns: 20b ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c
    SP1:                    -                     
    SP2:                    -                     
    SP3:                    -                     
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for IKBKB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    IKBKB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IKBKB Expression
    About this image


    IKBKB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Peripheral blood-derived hematopoietic stem cells (family)
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
    IKBKB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IKBKB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.597664

    UniProtKB/Swiss-Prot: IKKB_HUMAN, O14920
    Tissue specificity: Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus,
    prostate, testis and peripheral blood

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IKBKB (see all 12): 
              mTOR Signaling in human mouse rat
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for IKBKB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IKBKB
    QuantiTect SYBR Green Assays in human, mouse, rat IKBKB
    QuantiFast Probe-based Assays in human, mouse, rat IKBKB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKBKB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for IKBKB gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ikbkb1 , 5 inhibitor of kappaB kinase beta1, 5 87.15(n)1
    92.72(a)1
      8 (11.42 cM)5
    161501  NM_001159774.11  NP_001153246.11 
     226592125 
    chicken
    (Gallus gallus)
    Aves IKBKB1 inhibitor of kappa light polypeptide gene enhancer more 67.94(n)
    69.49(a)
      426792  NM_001031397.1  NP_001026568.1 
    lizard
    (Anolis carolinensis)
    Reptilia IKBKB6
    inhibitor of kappa light polypeptide gene enhancer...
    75(a)
    1 ↔ 1
    GL343545.1(348157-366756)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ040494.12   -- 78.25(n)    BJ040494.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ikbkb1 inhibitor of kappa light polypeptide gene enhancer more 62.47(n)
    61.71(a)
      563560  NM_001123265.1  NP_001116737.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ird53 antibacterial humoral response (sensu
    Invertebrata) more
    34(a)   89B3   --


    ENSEMBL Gene Tree for IKBKB (if available)
    TreeFam Gene Tree for IKBKB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for IKBKB gene
    IKBKE2  CHUK2  TBK12  
    17 SIMAP similar genes for IKBKB using alignment to 12 protein entries:     IKKB_HUMAN (see all proteins):
    CHUK    PKN2    RPS6KA2    PNCK    PRKCH    PRKD3
    MARK4    DAPK3    DKFZp564L2416    NEK9    PAK2    DAPK1
    MAPK14    NUAK1    STK25    STK36    TYK2

    IKBKB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for IKBKB (see all 1499)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356264
    Breast cancer samples4--see VAR_0356262 A S mis40--------
    rs1850274881,2
    --40654617(+) GTGGGC/TGATAG 6 -- us2k10--------
    rs132716231,2
    A--40717857(+) gcctgA/Gccaac 6 -- ds50011Minor allele frequency- G:0.00NA 2
    rs132821791,2
    A--40717867(+) catggA/Tgaaac 6 -- ds50011Minor allele frequency- T:0.00NA 2
    rs132748031,2
    C,A--40717876(+) ACCCCG/ATCTCT 6 -- ds50011Minor allele frequency- A:0.00NA 2
    rs1920887531,2
    --40717899(+) TTAGCC/TGGGCA 6 -- ds50010--------
    rs1891424841,2
    --42127447(+) TTTTGA/GCTGTT 6 -- us2k10--------
    rs92986211,2
    C,F,H--42127453(+) CTGTTT/CTCAAT 6 -- us2k1 tfbs311Minor allele frequency- C:0.05NS EA NA CSA WA 1212
    rs1406621841,2
    --42127609(+) CTCCTA/TCTGAA 6 -- us2k10--------
    rs178757391,2
    C,F--42127643(+) CACGGA/CTTAAG 6 -- us2k16Minor allele frequency- C:0.05NS NA 204

    HapMap Linkage Disequilibrium report for IKBKB (42128820 - 42190171 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for IKBKB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736935CNV Deletion23290073
    esv1003654CNV Deletion20482838
    dgv128n16CNV Deletion17901297
    esv1761681CNV Deletion17803354
    nsv398024CNV Loss16902084
    nsv831301CNV Loss17160897
    nsv6169CNV Loss18451855
    nsv508508CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IKBKB
    DNA2.0 Custom Variant and Variant Library Synthesis for IKBKB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603258   
    OMIM disorders: 615592  
    Selected diseases for IKBKB (see all 69):    
    About MalaCards
    immunodeficiency 15    shigellosis    eosinophilia    duchenne muscular dystrophy
    insulin resistance    trypanosomiasis    human t-cell leukemia virus type 1    toxoplasmosis
    chagas disease    skin disease    cutaneous t cell lymphoma    pneumonia
    myeloma    chondrosarcoma    b-cell chronic lymphocytic leukemia    gastritis
    vaccinia    psoriasis    encephalomyelitis    chronic lymphocytic leukemia


    IKBKB for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for IKBKB gene (see all 31)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 70.8 40 11054378 (2), 9710600 (1), 16085647 (1), 9346485 (1) (see all 34)
    leukemia t-cell 57.7 2 9632633 (1), 10648602 (1)
    tumors 56.6 61 11054378 (2), 19818716 (2), 15492250 (2), 9710600 (1) (see all 45)
    inflammation 52.3 22 16517756 (3), 15731493 (2), 16002568 (2), 14704736 (1) (see all 15)
    cancer 42.4 16 15617879 (2), 18702457 (2), 11520600 (1), 16175180 (1) (see all 12)
    insulin resistance 33 15 18240344 (3), 15617879 (2), 15351728 (2), 12021247 (1) (see all 9)
    rheumatoid arthritis 23.2 7 12847684 (2), 11160335 (1), 15316093 (1), 17067557 (1)
    shock 19.1 3 18282612 (1), 16309849 (1), 16424045 (1)
    breast cancer 13.7 14 19526344 (4), 17016640 (2), 15084260 (1), 16357145 (1) (see all 9)
    bacterial infections 7.76 1 9819420 (1)

    Genetic Association Database (GAD): IKBKB
    Human Genome Epidemiology (HuGE) Navigator: IKBKB (20 documents)

    Export disorders for IKBKB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for IKBKB gene, integrated from 10 sources (see all 712):
    (articles sorted by number of sources associating them with IKBKB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization. (PubMed id 9763654)1, 2, 3 Shindo M.... Okumura K. (Cytogenet. Cell Genet. 1998)
    2. Ro52-mediated monoubiquitination of IKK{beta} down-regulates NF-{kappa}B signalling. (PubMed id 19675099)1, 2, 9 Wada K.... Kamitani T. (J. Biochem. 2009)
    3. Site-specific monoubiquitination of IkappaB kinase IKKbeta regulates its phosphorylation and persistent activation. (PubMed id 16267042)1, 2, 9 Carter R.S.... Ballard D.W. (J. Biol. Chem. 2005)
    4. The IkappaB kinase complex: master regulator of NF-kappaB signaling. (PubMed id 18626576)1, 2, 9 Solt L.A. and May M.J. (Immunol. Res. 2008)
    5. Activation of IkappaB kinase beta by protein kinase C isoforms. (PubMed id 10022904)1, 2, 9 Lallena M.J.... Moscat J. (Mol. Cell. Biol. 1999)
    6. IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes. (PubMed id 9813230)1, 2, 9 Hu M.C.-T. and Wang Y.-P. (Gene 1998)
    7. Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity. (PubMed id 17114296)1, 2, 9 Cummins E.P....Taylor C.T. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    8. Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation. (PubMed id 12612076)1, 2, 9 Tegethoff S.... Scheidereit C. (Mol. Cell. Biol. 2003)
    9. Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. (PubMed id 10195894)1, 2, 9 Delhase M.... Karin M. (Science 1999)
    10. FAF1 suppresses IkappaB kinase (IKK) activation by disrupting the IKK complex assembly. (PubMed id 17684021)1, 2, 9 Park M.Y....Kim E. (J. Biol. Chem. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3551 HGNC: 5960 AceView: IKBKB Ensembl:ENSG00000104365 euGenes: HUgn3551
    ECgene: IKBKB Kegg: 3551 H-InvDB: IKBKB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for IKBKB Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/ikbkb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for IKBKB gene:
    Search GeneIP for patents involving IKBKB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Purified and/or Recombinant IKBKB Protein
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of IKBKB
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for IKBKB (IKK beta)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for IKBKB   OriGene RNAi products in human, mouse, rat for IKBKB  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for IKBKB  
     OriGene MassSpec something-or-other for IKBKB   OriGene clones in human, mouse for IKBKB  
     OriGene qSTAR qPCR primer pairs in human, mouse for IKBKB   OriGene Purified Protein for IKBKB  
     OriGene ORF clones in mouse, rat for IKBKB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for IKBKB   OriGene Custom Protein Services for IKBKB  

     
     
     Block miRNA regulation of human, mouse, rat IKBKB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing IKBKB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IKBKB Predesigned siRNA for gene silencing in human, mouse, rat IKBKB
     QuantiFast Probe-based Assays in human, mouse, rat IKBKB QuantiTect SYBR Green Assays in human, mouse, rat IKBKB
     PCR Arrays including human, mouse, rat IKBKB Search Chromatin IP Primers for IKBKB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IKBKB  GeneGlobe Interaction Network for IKBKB
     Regulatory tfbs in IKBKB promoter
     GenScript Custom Purified and Recombinant Proteins Services for IKBKB GenScript cDNA clones with any tag delivered in your preferred vector for IKBKB
     GenScript Custom Assay Services for IKBKB GenScript Custom overexpressing Cell Line Services for IKBKB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for IKBKB  (IKKB)

     Tocris compounds for IKBKB
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for IKBKB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for IKBKB
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     IKBKB antibodies
     IKBKB proteins
     IKBKB lysates
     Antibodies for IKBKB
     See all of Abcam's Antibodies, Kits and Proteins for IKBKB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for IKBKB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKBKB
     SwitchGear 3'UTR luciferase reporter plasmids for IKBKB
     SwitchGear Promoter luciferase reporter plasmids for IKBKB
     ThermoFisher Antibody for IKBKB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKBKB
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IKBKB
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IKBKB
     LSBio Antibodies in human, mouse, rat for IKBKB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      IKBKB gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4