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IKBKB Gene

protein-coding GIFtS: 69

GC08P042247

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.11.10 ^³
FLJ40509 ^²
IKK-B ^³
IKK-beta ^¹, ², ³
IKK2 ^¹, ², ³
IKKB ^¹, ², ³
IkBKB ^³
MGC131801 ^²
NFKBIKB ^¹, ², ³, ⁵

Descriptions
I-kappa-B kinase 2 ^³
I-kappa-B-kinase beta ^³
Nuclear factor NF-kappa-B inhibitor kinase beta ^², ³
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta ^²
inhibitor of nuclear factor kappa B kinase beta subunit ^²

External Ids
HGNC: 5960¹
Entrez Gene: 3551²
UniProtKB: O14920³
Ensembl: ENSG00000104365⁷

Search outside databases for aliases for IKBKB gene

Previous GC identifers: GC08M041757 GC08P042157 GC08P041869 GC08P042146

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IKBKB:

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB

(MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins

(NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the

cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM

600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing

activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and

binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC

3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by

OMIM]

UniProtKB/Swiss-Prot: IKKB_HUMAN, O14920

Function: Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and

phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the

inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates

NCOA3

Gene Wiki entry for IKBKB (IKK2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IKBKB gene

Entrez Gene cytogenetic band: 8p11.2 Ensembl cytogenetic band: 8p11.21 HGNC cytogenetic band: 8p11.2

IKBKB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P042247: (about GC identifiers)

Start:	42,247,986 bp from pter
End:	42,309,122 bp from pter
Size:	61,137 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000008.9 NT_007995.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IKKB_HUMAN, O14920 (See protein sequence)

Recommended Name: Inhibitor of nuclear factor kappa-B kinase subunit beta

Size: 756 amino acids; 86564 Da

Subunit: Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG;

probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK

core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome

holo-complex. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Part

of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14.

Interacts with SQSTM1 through PRKCZ or PRKCI. Forms an NGF-induced complex with IKBKB, PRKCI and

TRAF6. May interact with MAVS/IPS1. Interacts with NALP2. Interacts with TICAM1. Interacts with

Yersinia yopJ. Interacts with FAF1; the interaction disrupts the IKK complex formation. Interacts

with ATM. Part of a ternary complex consisting of TANK, IKBKB and IKBKG. Interacts with NIBP; the

interaction is direct

Subcellular location: Cytoplasm

PDB structure from and Proteopedia :

3BRT (3D)

3BRV (3D)

Secondary accessions: O75327

Post-translational modifications:

Upon cytokine stimulation, phosphorylated on Ser-177 and Ser-181 by MEKK1 and/or MAP3K14/NIK; which

enhances activity. Once activated, autophosphorylates on the C-terminal serine cluster; which

decreases activity and prevents prolonged activation of the inflammatory response¹

Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, which

blocks the I-kappa-B signaling pathway¹

Ubiquitination on 'Ser-163' modulates phosphorylation on C-terminal serine residues¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001547.1

ENSEMBL proteins:

ENSP00000369030 ENSP00000339151

Human Recombinant Proteins

	Invitrogen human recombinant proteins for IKBKB
	Millipore Purified and/or Recombinant IKBKB Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (IKK beta, IKK alpha + IKK beta)
	Human Recombinant Proteins from Abnova (IKBKB)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	EXP	9744859 10723127

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Antibodies for IKBKB:

	Invitrogen Antibodies for IKBKB
	Millipore Mono- and Polyclonal Antibodies for the study of IKBKB
	Sigma-Aldrich Antibodies for IKBKB
	R&D Systems Antibodies for IKBKB (IKK beta)
	Cell Signaling Technology (CST) Antibodies for IKBKB (IKKb)
	Antibodies from Abcam (IKK beta, IKK alpha + IKK beta), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IKBKB)
	Novus Biologicals Antibodies for IKBKB

Assays for IKBKB:

	Invitrogen Assays for IKBKB
	Millipore Kits and Assays for the Analysis of IKBKB
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O14920

ProtoNet protein and cluster: O14920

1 Blocks protein family: IPB000626 Ubiquitin domain

UniProtKB/Swiss-Prot: IKKB_HUMAN, O14920

Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B

kinase subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IKBKB)
		Millipore RNAi Products for the Analysis of IKBKB Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (IKBKB)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001556

Applied Biosystems Silencer® siRNAs for IKBKB

Sigma-Aldrich siRNA and siRNA Panels for IKBKB

Sigma-Aldrich shRNA Panels and shRNA for IKBKB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IKBKB
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001556
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001556
untagged cDNA clones in CMV expression vector (see all 2): NM_001556

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001556

UniProtKB/Swiss-Prot: IKKB_HUMAN, O14920

Function: Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and

phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the

inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates

NCOA3

Catalytic activity: ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein]

Enzyme Number (IUBMB): EC 2.7.11.10

Genatlas biochemistry entry for IKBKB:

inhibitor of kappa light polypeptide enhancer in B cells,kinase beta,complexing with IKBKA

15/18 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Ikbkb) (see all 18 ):

	cellular	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	liver/biliary system	muscle

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0008384	IkappaB kinase activity	IEA	--
GO:0016563	transcription activator activity	NAS	9346484 9346485 9813230
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/39 Sigma-Aldrich "Your Favorite Gene" Pathways for IKBKB (Your Favorite Gene powered by Ingenuity) (see all 39 )

PPAR Signaling
Role of PKR in Interferon Induction and Antiviral Response
Chronic Myeloid Leukemia Signaling
Hepatic Cholestasis
Acute Phase Response Signaling

GeneDecks IKBKB for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for IKBKB

5/182 Interacting proteins for IKBKB (O14920^{1, 2} ENSP00000339151³) via UniProtKB, MINT, and/or STRING (see all 182 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NFKB2	Q00653², ENSP00000337001³	MINT-48728 MINT-48594 MINT-47899 STRING (score=.998)
CDC37	Q16543², ENSP00000222005³	MINT-47956 MINT-48072 STRING (score=.902)
NFKBIB	Q15653², ENSP00000312988³	MINT-47854 STRING (score=.999)
RELA	Q04206², ENSP00000311508³	MINT-50167 STRING (score=.999)
MAP3K7	O43318², ENSP00000358335³	MINT-4652778 STRING (score=.996)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001782	B cell homeostasis	IEA	--
GO:0006464	protein modification process	IEA	--
GO:0006468	protein amino acid phosphorylation	NAS	9346484
GO:0051092	positive regulation of NF-kappaB transcription factor activity	IDA	15790681

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for IKBKB

Sigma-Aldrich Small Molecules for IKBKB:

Inhibitor

Compounds for IKBKB available from Tocris Bioscience

Compound	Action	CAS number
SC 514	IKK-2 inhibitor; attenuates NF-kappaB-induced gene expression	[354812-17-2]
TPCA-1	Potent, selective inhibitor of IKK-2	[507475-17-4]
IMD 0354	Inhibitor of IKK-2	[978-62-1]

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10/25 Novoseek chemical compound relationships for IKBKB gene (see all 25 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tab-1	74.03	6	10187861 (2), 18316610 (2), 17439942 (1), 17673602 (1)
sp 600125	40.27	2	16896943 (1), 19097143 (1)
12-o-tetradecanoylphorbol 13-acetate	33.17	6	11054378 (1), 12707358 (1), 18234971 (1), 12645577 (1) (see all 5)
threonine	31.59	3	11337492 (1), 9804849 (1), 11297557 (1)
leucine	30.26	8	9346241 (2), 12459277 (1), 11359906 (1), 12890679 (1) (see all 6)
pd 98,059	29.07	1	15821443 (1)
phosphatidylinositol	27.56	3	14585846 (2), 11279241 (1)
rantes	26.45	2	12917470 (1), 16687566 (1)
phosphoinositide	22.64	1	11389085 (1)
tyrosine	15.80	11	12707358 (2), 11093788 (2), 11483407 (2), 12645577 (2) (see all 7)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IKBKB)
		Millipore RNAi Products for the Analysis of IKBKB Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (IKBKB)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001556

Sigma-Aldrich siRNA and siRNA Panels for IKBKB

Sigma-Aldrich shRNA Panels and shRNA for IKBKB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001556

REFSEQ mRNAs for IKBKB gene:

NM_001556.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001556

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001556
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001556
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001556

Additional cDNA sequence:

AB209090.1 AF029684.1 AF031416.1 AF080158.1 AK023193.1 AK091090.1 AK091297.1 AK093537.1

AK095687.1 AK097828.1 AK290952.1 AK298241.1 AK302723.1 AK303294.1 AK303528.1 AK309052.1

AK316418.1 BC006231.2 BC090865.1 BC108694.1 BC127663.1 BC141978.1 BC144080.1 BX648165.1

CR607076.1 CR623637.1

21 DOTS entries:

DT.100027604 DT.99972055 DT.100791549 DT.455185 DT.40109373 DT.95129544 DT.75182159 DT.100791546

DT.432043 DT.95111224 DT.92009888 DT.100734046 DT.121483438 DT.92414557 DT.75122049 DT.91703816

DT.99940339 DT.121483354 DT.121483433 DT.91860992 DT.91926378

24/210 AceView cDNA sequences (see all 210 ):

AW194527 CR623637 BU857051 AW611888 CA306506 BQ006314 CA308037 BC006231

AI453201 AI264203 CD251031 BQ059522 AI536653 AF080158 AI823943 AW449114

BU732786 AA938658 BQ050714 BM769773 BX097180 BE384533 CD243765 BP431007

highest scoring ESTs for IKBKB:

AA128021 AI453201 AI699170 AJ714702 BM463333 CK821474 AA521493 AF031416 AI379342 N21119

Unigene Cluster for IKBKB:

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

Hs.597664 [show with all ESTs]

Unigene Representative Sequence: AB209090

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IKBKB (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17a	·	17b	·	17c	^	18	^	19	^	20a	·
SP1:							-																-								-										-		-
SP2:																							-								-								-		-		-
SP3:							-				-		-		-		-		-		-		-								-										-		-
SP4:							-																-
SP5:							-

ExUns:	20b	^	21	^	22a	·	22b	^	23a	·	23b	·	23c
SP1:							-
SP2:							-
SP3:							-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for IKBKB

2 Ensembl transcripts including schematic representations:

ENST00000379708 ENST00000342222

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IKBKB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IKBKB

¹ / ² / ³

11 probe-sets matching IKBKB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35960_at²^{, 3}	U95-A	1	1.00	1.00	0.82	0.75	AF031416	0.80	0.80	0.80	1
65461_r_at²^{, 3}	U95-C	1	1.00	1.00	0.83	0.79	N21119	0.80	0.80	0.80	1
54679_g_at²^{, 3}	U95-B	1	1.00	1.00	0.97	1.21	AA521493	0.80	0.80	0.80	1
54675_at²^{, 3}	U95-B	1	1.00	1.00	0.93	1.33	AA521493	0.80	0.80	0.80	1
44812_at²^{, 3}	U95-B	1	0.56	1.00	0.96	0.92	AI379342	0.80	0.80	0.80	1
209342_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF080158	0.60	0.75	0.68	1
209341_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AU153366	0.60	0.75	0.68	1
211027_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC006231	0.40	0.67	0.55	1
209342_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209341_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211027_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks IKBKB for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.597664
Expression variation in blood from EXPOLDB for IKBKB
UniProtKB/Swiss-Prot: IKKB_HUMAN, O14920
Tissue specificity: Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen,
thymus, prostate, testis and peripheral blood

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IKBKB gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IKBKB¹	--	inhibitor of kappa light polypeptide gene enhancer more	90.11(n) 95.1(a)	482839 XM_539954.2 XP_539954.2
chimpanzee (Pan troglodytes)	IKBKB¹	--	inhibitor of kappa light polypeptide gene enhancer more	97.88(n) 97.62(a)	472749 XM_528121.2 XP_528121.2
cow (Bos taurus)	IKBKB¹	--	inhibitor of kappa light polypeptide gene enhancer more	86.55(n) 93.25(a)	281854 NM_174353.2 NP_776778.1
rat (Rattus norvegicus)	Ikbkb¹	--	inhibitor of kappaB kinase beta	87.11(n) 91.52(a)	84351 NM_053355.1 NP_445807.1
mouse (Mus musculus)	Ikbkb^{1, 5}	8⁵	inhibitor of kappaB kinase beta^{1, 5}	87.35(n)¹ 93.33(a)¹	16150¹ NM_010546.1¹ NP_034676.1¹ AA203913⁵ AF026524⁵ (see all 36)

About this table Species with no ortholog for IKBKB

ENSEMBL Gene Tree for IKBKB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IKBKB gene

IKBKE² CHUK² TBK1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/321 NCBI SNPs in IKBKB are shown (see all 321 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 133)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs9298621^1,2	C,F,H	42246610(+)	`CTGTTT/CTCAAT`	1	--	ng5¹ tfbs³		4		EU EA WA	418
	rs2272736^1,2	C,F,H	42296320(+)	`TGGGCG/AGGTAG`	1	Q/R	mis¹ ese³		9		EA EU WA	2274
	rs1057741^1,2	A,C,F	42307707(+)	`TGTGCG/AGTGGG`	1	--	ut3¹		5		NA NS	232
--	rs10108113^1,2	C,H	42308597(+)	`TATATT/CTTGTA`	1	--	ut3¹		3		EU EA	298
--	rs13270719^1,2	A	42309621(+)	`tgagcA/Cgagat`	1	--	ng3¹		0	--	--	--	--
--	rs13278231^1,2	A	42309597(+)	`gaaccC/Taggag`	1	--	ng3¹		0	--	--	--	--
--	rs13270698^1,2	A	42309598(+)	`aacctA/Gggagg`	1	--	ng3¹		0	--	--	--	--
	rs6991366^1,2	H	42270175(+)	`CCTTGC/ATGAGT`	1	M/L	mis¹		4		EU EA WA	418
	rs7825781^1,2	H	42246813(+)	`CCCGGG/CAACCA`	1	--	ng5¹		4		EU EA WA	398
--	rs17611716^1,2	H	42307589(+)	`TTCAGG/ACCCTA`	1	T/A	mis¹		7		NA EU EA WA	548

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HapMap Linkage Disequilibrium images for IKBKB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 603258

10/30 Novoseek disease relationships for IKBKB gene (see all 30 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	70.56	39	11054378 (2), 9710600 (1), 16085647 (1), 9346485 (1) (see all 33)
leukemia t-cell	59.29	2	9632633 (1), 10648602 (1)
tumors	55.84	54	11054378 (2), 15492250 (2), 9710600 (1), 15084260 (1) (see all 41)
inflammation	51.48	22	16517756 (3), 15731493 (2), 16002568 (2), 14704736 (1) (see all 15)
cancer	40.19	13	15617879 (2), 18702457 (2), 11520600 (1), 18037881 (1) (see all 9)
insulin resistance	31.63	14	18240344 (3), 15617879 (2), 15351728 (2), 12021247 (1) (see all 8)
rheumatoid arthritis	22.48	7	12847684 (2), 11160335 (1), 15316093 (1), 17067557 (1)
shock	20.14	3	18282612 (1), 16309849 (1), 16424045 (1)
bacterial infections	10.94	1	9819420 (1)
breast cancer	10.47	8	17016640 (2), 15084260 (1), 16357145 (1), 11325857 (1) (see all 7)

About this table

Genetic Association Database: IKBKB
Human Genome Epidemiology Navigator: IKBKB (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/472 PubMed articles for IKBKB gene (see all 472 ):

Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization. (PubMed id 9763654)^{2, 3, 4} Shindo M.... Okumura K. (1998)
Site-specific monoubiquitination of IkappaB kinase IKKbeta regulates its phosphorylation and persistent activation. (PubMed id 16267042)^{1, 3, 4} Carter R.S....Ballard D.W. (2005)
IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes. (PubMed id 9813230)^{1, 3, 4} Hu M.C.-T. and Wang Y.-P. (1998)
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. (PubMed id 10195894)^{1, 3, 4} Delhase M.... Karin M. (1999)
FAF1 suppresses IkappaB kinase (IKK) activation by disrupting the IKK complex assembly. (PubMed id 17684021)^{1, 3, 4} Park M.Y....Kim E. (2007)
NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF- (kappa)B activation. (PubMed id 15951441)^{1, 3, 4} Hu W.H.... Bethea J.R. (2005)
Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase. (PubMed id 9819420)^{1, 3, 4} Nemoto S.... Lin A. (1998)
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. (PubMed id 9346485)^{1, 3, 4} Woronicz J.D.... Goeddel D.V. (1997)
The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. (PubMed id 10356400)^{1, 3, 4} Sanz L.... Moscat J. (1999)
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF- kappaB activation. (PubMed id 9346484)^{1, 3, 4} Mercurio F.... Rao A. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3551	HGNC: 5960	AceView: IKBKB	Ensembl:ENSG00000104365	euGenes: HUgn3551
ECgene: IKBKB	H-InvDB: IKBKB

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
SeattleSNPs	http://pga.gs.washington.edu/data/ikbkb/

Licensable Technologies for IKBKB
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IKBKB:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IKBKB-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IKBKB		Antibodies for IKBKB
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IKBKB		Small molecules for IKBKB
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IKBKB)
	Antibodies (IKBKB)
	Chimera RNAi (IKBKB)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for IKBKB (IKKb)

	Recombinant Proteins (IKK beta, IKK alpha + IKK beta)
	Antibodies (IKK beta, IKK alpha + IKK beta)

Search OriGene for IKBKB

Tocris compounds for IKBKB

	Drugs for IKBKB
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for IKBKB

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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IKBKB Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for IKBKB

Summaries
for IKBKB

Genomic Location
for IKBKB

Proteins
for IKBKB

Protein Domains/
Families
for IKBKB

Gene Function
for IKBKB

Pathways & Interactions
for IKBKB

Drugs & Compounds
for IKBKB

Transcripts
for IKBKB

Expression
for IKBKB

Orthologs
for IKBKB

Paralogs
for IKBKB

SNPs/Variants
for IKBKB

Disorders & Mutations
for IKBKB

Medical News
for IKBKB

Publications
for IKBKB

Search for IKBKB

Genome Databases showing IKBKB

Other Databases showing IKBKB

Specialized Databases showing IKBKB

Licensable Technologies
for IKBKB

Services
for IKBKB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IKBKB Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor IKBKB

Summariesfor IKBKB

Genomic Locationfor IKBKB

Proteinsfor IKBKB

Protein Domains/Familiesfor IKBKB

Gene Functionfor IKBKB

Pathways & Interactionsfor IKBKB

Drugs & Compoundsfor IKBKB

Transcriptsfor IKBKB

Expression for IKBKB

Orthologsfor IKBKB

Paralogsfor IKBKB

SNPs/Variantsfor IKBKB

Disorders & Mutationsfor IKBKB

Medical Newsfor IKBKB

Publicationsfor IKBKB

Search for IKBKB

Genome Databases showing IKBKB

Other Databases showing IKBKB

Specialized Databases showing IKBKB

Licensable Technologiesfor IKBKB

Servicesfor IKBKB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IKBKB

Summaries
for IKBKB

Genomic Location
for IKBKB

Proteins
for IKBKB

Protein Domains/
Families
for IKBKB

Gene Function
for IKBKB

Pathways & Interactions
for IKBKB

Drugs & Compounds
for IKBKB

Transcripts
for IKBKB

Expression
for IKBKB

Orthologs
for IKBKB

Paralogs
for IKBKB

SNPs/Variants
for IKBKB

Disorders & Mutations
for IKBKB

Medical News
for IKBKB

Publications
for IKBKB

Licensable Technologies
for IKBKB

Services
for IKBKB