IKBKB Gene
protein-coding GIFtS: 71
GCID: GC08P042146
|
|
inhibitor of kappa light polypeptide gene enhancer in B-cells,...
| |
Aliases
for IKBKB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, KinaseBeta1 2 | | I-Kappa-B Kinase 22 3 | | NFKBIKB1 2 3 5 | | I-Kappa-B-Kinase Beta2 3 | | IKK-Beta1 | | EC 2.7.11.103 8 | | IKK21 2 3 | | Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Beta2 | | IKKB1 2 3 | | IkBKB3 | | Nuclear Factor NF-Kappa-B Inhibitor Kinase Beta2 3 | | EC 2.7.118 | | IKK-B2 3 | | |
| External Ids: | HGNC: 59601 | Entrez Gene: 35512 | Ensembl: ENSG000001043657 | OMIM: 6032585 | UniProtKB: O149203 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n409416 | |
Export aliases for IKBKB gene to outside databasesPrevious GC identifers: GC08M041757 GC08P042157 GC08P041869 GC08P042247 GC08P040656
Summaries
for IKBKB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IKBKB:
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociationof the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Severaltranscript variants, some protein-coding and some not, have been found for this gene. (provided by RefSeq, Sep 2011)
UniProtKB/Swiss-Prot: IKKB_HUMAN, O14920Function: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiplestimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts aspart of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitorsof NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors andsubsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates thetranscription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Inaddition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway includingNEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinasephosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation oncanonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as anadapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation
 summary
for IKBKB: IkappaB Kinase (IKK) is an enzyme complex that forms part of the NF-kappaB signaling pathway. The complex is
comprised of three subunits (IKKalpha (IKK1), IKKbeta (IKK2) and IKKgamma (NEMO)), the alpha- and
beta-subunits are catalytically active whereas the gamma-subunit serves a regulatory function. Activation of
NF-kappaB occurs via degradation of IkappaB, a process that is initiated by its phosphorylation by IkappaB
kinase (IKK). Phosphorylated IkappaB becomes dissociated from NF-kappaB, unmasking the NLS. Phosphorylation
also results in IkappaB ubiquitination and targeting to the proteasome. NF-kappaB can now enter the nucleus
and regulate gene expression.
Gene Wiki entry for IKBKB (IKK2)
|
Genomic Views
for IKBKB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IKBKB gene promoter:
Max1 ER-alpha C/EBPbeta STAT1 p53 RREB-1 HTF POU3F2 C/EBPalpha c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for IKBKB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IKBKB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p11.2 Ensembl cytogenetic band: 8p11.21 HGNC cytogenetic band: 8p11.2IKBKB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P042146: view genomic region
(about GC identifiers)
Start:
|
42,128,820 bp from pter |
End:
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42,190,171 bp from pter |
Size:
|
61,352 bases |
Orientation:
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plus strand |
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Proteins
for IKBKB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IKKB_HUMAN, O14920 (See
protein sequence)Recommended Name: Inhibitor of nuclear factor kappa-B kinase subunit beta Size: 756 amino acids; 86564 Da
Subunit: Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably fouralpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associatewith regulatory or adapter proteins to form a IKK-signalosome holo-complex. The IKK complex associates withTERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65. Part of a complex composed of NCOA2, NCOA3,CHUK/IKKA, IKBKB, IKBKG and CREBBP. Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA,IKBKAP and MAP3K14. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Interactswith SQSTM1 through PRKCZ or PRKCI. Forms an NGF-induced complex with IKBKB, PRKCI and TRAF6. May interact withMAVS/IPS1. Interacts with NALP2. Interacts with TICAM1. Interacts with Yersinia yopJ. Interacts with FAF1; theinteraction disrupts the IKK complex formation. Interacts with ATM. Part of a ternary complex consisting of TANK,IKBKB and IKBKG. Interacts with NIBP; the interaction is direct. Interacts with ARRB1 and ARRB2. Interacts withTRIM21. Interacts with NLRC5; prevents IKBKB phosphorylation and kinase activity. Interacts with PDPK1
Subcellular location: Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts
2 PDB 3D structures from  and Proteopedia  for IKBKB:3BRT (3D)
3BRV (3D)
Secondary accessions: B4DZ30 B4E0U4 O75327Alternative splicing: 4 isoforms: O14920-1 O14920-2 O14920-3 O14920-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for IKBKB: NX_O14920
Post-translational modifications:
Upon cytokine stimulation, phosphorylated on Ser-177 and Ser-181 by MEKK1 and/or MAP3K14/NIK as well as TBK1 and PRKCZ;which enhances activity. Once activated, autophosphorylates on the C-terminal serine cluster; which decreases activityand prevents prolonged activation of the inflammatory response. Phosphorylated by the IKK-related kinases TBK1 andIKBKE, which is associated with reduced CHUK/IKKA and IKBKB activity and NF-kappa-B-dependent gene transcription1
Acetylation of Thr-180 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the I-kappa-B pathway1
Ubiquitinated. Monoubiquitination involves TRIM21 that leads to inhibition of Tax-induced NF-kappa-B signaling.According to PubMed:19675099, 'Ser-163' does not serve as a monoubiquitination site. According to PubMed:16267042,ubiquitination on 'Ser-163' modulates phosphorylation on C-terminal serine residues. Monoubiquitination by TRIM21 isdisrupted by Yersinia yopJ1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14920
4/11 DME Specific Peptides for IKBKB (O14920) (see all 11)
IKBKB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001177649.1 NP_001229707.1 NP_001547.1
ENSEMBL proteins: ENSP00000430684 ENSP00000429699 ENSP00000428799 ENSP00000429319 ENSP00000430483 ENSP00000429239 ENSP00000430868 ENSP00000430557 ENSP00000339151 ENSP00000427978 ENSP00000429924 ENSP00000428186 ENSP00000428922 ENSP00000429357 ENSP00000428892 ENSP00000430114 ENSP00000404920 ENSP00000369030 Reactome Protein details: O14920
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
IKBKB for ontologies About GeneDecksing
IKBKB Antibody Products:
Assay Products for IKBKB: |
Protein
Domains /
Families
for IKBKB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IKBKB for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O14920ProtoNet protein and cluster: O14920 1 Blocks protein family: IPB000626 Ubiquitin domain
UniProtKB/Swiss-Prot: IKKB_HUMAN, O14920Domain: The kinase domain is located in the N-terminal region. The leucine zipper is important to allow homo- andhetero-dimerization. At the C-terminal region is located the region responsible for the interaction with NEMO/IKBKGSimilarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamilySimilarity: Contains 1 protein kinase domain |
Function
for IKBKB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IKKB_HUMAN, O14920Function: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiplestimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts aspart of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitorsof NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors andsubsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates thetranscription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Inaddition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway includingNEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinasephosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation oncanonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as anadapter protein for NFKBIA degradation in UV-induced NF-kappa-B activationCatalytic activity: ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein] Genatlas biochemistry entry for IKBKB:inhibitor of kappa light polypeptide enhancer in B cells,kinase beta,complexing with IKBKA
Enzyme Numbers (IUBMB): EC 2.7.11.101 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IKBKB (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IKBKB (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): IKBKB (NM_001556) | |  | Sino Biological Human cDNA Clone for IKBKB | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IKBKB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKBKB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKBKB |
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
IKBKB for ontologies About GeneDecksing
7 GenomeRNAi human phenotypes for IKBKB:
Animal Models:
Mouse knock-outs for IKBKB: Ikbkbtm1Ver Ikbkbtm2.1Cgn Ikbkbtm1.1Cgn Ikbkbtm1Mka Ikbkbtm1Trk Ikbkbtm2.1Mka
15 MGI mutant phenotypes (inferred from 11 alleles ) (MGI details for Ikbkb):
IKBKB for phenotypes About GeneDecksing
|
Pathways & Interactions
for IKBKB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/111 super-pathways (see all 111) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | TWEAK Pathway | | | 3 | 4-1BB Pathway | | | 4 | RIP-mediated NFkB activation via DAI | | | 5 | BAFF in B-Cell Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/36 EMD Millipore Pathways for IKBKB (see all 36)
2  R&D Systems Pathways for IKBKB
5/63 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IKBKB (see all 63)
2 
Cell Signaling Technology (CST) Pathways for IKBKB
5 Tocris Bioscience Pathways for IKBKB
5/44  GeneGo (Thomson Reuters) Pathways for IKBKB (see all 44)
5/32  BioSystems Pathways for IKBKB (see all 32)
5/49 
Reactome Pathways for IKBKB (see all 49)
5/26 
Kegg Pathways (Kegg details for IKBKB) (see all 26):
IKBKB for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IKBKB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/259 Interacting proteins for IKBKB (O149201, 2, 3 ENSP000003391514) via UniProtKB, MINT, STRING, and/or I2D (see all 259)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| IKBKG | Q9Y6K91, 2, 3, ENSP000003586224 | EBI-81266,EBI-356130 MINT-48065 MINT-48174 MINT-47971 MINT-3089484 MINT-5115044 I2D:
score=9 STRING: ENSP00000358622 | | CHUK | O151111, 2, 3, ENSP000003594244 | EBI-81266,EBI-81249 MINT-47955 MINT-48069 I2D:
score=11 STRING: ENSP00000359424 | | MAP3K14 | Q995581, 2, 3 | EBI-81266,EBI-358011 MINT-48000 MINT-48828 I2D:
score=7 | | NFKB2 | Q006532, 3, ENSP000001894444 | MINT-48728 MINT-48594 MINT-47899 I2D:
score=4 STRING: ENSP00000189444 | | HSP90AB1 | P082382, 3, ENSP000003258754 | MINT-48093 MINT-47958 I2D:
score=4 STRING: ENSP00000325875 |
About this table
Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001782 | B cell homeostasis |
IEA | -- | | GO:0002224 | toll-like receptor signaling pathway |
TAS | -- | | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
TAS | -- | | GO:0002756 | MyD88-independent toll-like receptor signaling pathway |
TAS | -- | | GO:0003009 | skeletal muscle contraction |
-- | -- |
IKBKB for ontologies About GeneDecksing
|
Drugs & Compounds
for IKBKB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
IKBKB for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for IKBKB |
Compounds for IKBKB available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| SC 514 | IKK-2 inhibitor; attenuates NF-kappaB-induced gene expression | [354812-17-2] | | TPCA-1 | Potent, selective inhibitor of IKK-2 | [507475-17-4] | | IMD 0354 | Inhibitor of IKK-2 | [978-62-1] | | PF 184 | Potent and selective IKK-2 inhibitor | [1187460-81-6] |
3 HMDB Compounds for IKBKB About this table
4 DrugBank Compounds for IKBKB About this table
10/57 Novoseek chemical compound relationships for IKBKB gene (see all 57) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tab-1 |
72.7 |
6 |
10187861 (2), 18316610 (2), 17439942 (1), 17673602 (1) |
| bortezomib |
50.1 |
2 |
19436050 (1) |
| serine |
48.9 |
25 |
9804849 (2), 11444880 (2), 14704736 (1), 16896943 (1) (see all 22) |
| parthenolide |
43.6 |
2 |
10553091 (1), 15618150 (1) |
| sp 600125 |
41.8 |
2 |
16896943 (1), 19097143 (1) |
| herbimycin a |
41.8 |
2 |
15155828 (2) |
| geldanamycin |
41.7 |
2 |
16432176 (1), 15077173 (1) |
| pdtc |
40.8 |
6 |
19399830 (1), 20037166 (1), 16490171 (1), 16998220 (1) (see all 5) |
| sulindac |
37.3 |
8 |
19526344 (5), 15033733 (1), 10480951 (1) |
| salicylic acid |
34.6 |
9 |
9817203 (3), 10753891 (2), 10553070 (1), 10480951 (1) (see all 6) |
Search CenterWatch for drugs/clinical trials and news about IKBKB / IKKB
|
Transcripts
for IKBKB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IKBKB gene (5 alternative transcripts): NM_001190720.2 NM_001242778.1 NM_001556.2 NM_001190721.1 NM_001190722.1 Unigene Cluster for IKBKB: Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta Hs.597664 [show with all ESTs]Unigene Representative Sequence: NR_03381818/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30): ENST00000520810(uc011lco.2) ENST00000520320 ENST00000517890 ENST00000519733
ENST00000519735 ENST00000523105 ENST00000520835 ENST00000517917 ENST00000518679
ENST00000342222(uc003xox.2 uc010lxj.2 uc003xow.2 uc011lcp.2 uc011lcq.2 uc010lxi.2 uc011lcr.2)
ENST00000518983 ENST00000520201(uc010lxh.2 uc022auj.1) ENST00000517388
ENST00000518647(uc003xov.3) ENST00000521661 ENST00000520655 ENST00000517812
ENST00000522147
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IKBKB (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IKBKB (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): IKBKB (NM_001556) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IKBKB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKBKB |
Additional cDNA sequence: AF029684.1 AF031416.1 AF080158.1 AK091297.1 AK290952.1 AK298241.1 AK302723.1 AK303294.1 AK303528.1 AK316418.1 BC006231.2 BC090865.1 BC127663.1 BC141978.1 BC144080.1 HM245392.1 NR_033818.1 NR_033819.1 NR_040009.1 21 DOTS entries: DT.100027604 DT.99972055 DT.100791549 DT.455185 DT.95129544 DT.100791546 DT.75182159 DT.40109373 DT.432043 DT.95111224 DT.121483438 DT.75122049 DT.91703816 DT.99940339 DT.121483354 DT.121483433 DT.91860992 DT.91926378 DT.92009888 DT.92414557 DT.100734046 24/210 AceView cDNA sequences (see all 210): BM980513 BU732786 AI675938 BX097180 BM974500 BM353811 AI859897 AW449114 N22157 AW572693 CA429223 BC006231 BQ059522 AI440458 AW510331 CD251031 AW299768 AW004920 AA938658 AI453201 AI823943 CB270059 AI379342 AA832248
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IKBKB (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19 | ^ | 20a | · |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | · | 23c |
|---|
|
| SP1: | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for IKBKB
|
Expression
for IKBKB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IKBKB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See IKBKB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IKBKB
SOURCE GeneReport for Unigene cluster: Hs.597664
UniProtKB/Swiss-Prot: IKKB_HUMAN, O14920Tissue specificity: Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate,testis and peripheral blood
SABiosciences Expression via Pathway-Focused PCR Arrays including IKBKB (see all 12):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IKBKB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IKBKB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IKBKB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IKBKB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKBKB |
Orthologs
for IKBKB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for IKBKB gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
IKBKB1 |
inhibitor of kappa light polypeptide gene enhancer more |
67.76(n)
69.59(a) |
|
426792 NM_001031397.1 NP_001026568.1 |
lizard
(Anolis carolinensis) |
Reptilia |
IKBKB6 |
-- |
75(a) |
1 ↔ 1 |
GL343545.1(348172-366756) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ040494.12 |
-- |
78.25(n) |
|
BJ040494.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
ikbkb1 |
inhibitor of kappa light polypeptide gene enhancer more |
62.34(n)
61.84(a) |
|
563560 NM_001123265.1 NP_001116737.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
ird53 |
antibacterial humoral response (sensu
Invertebrata) more |
34(a) |
|
89B3 -- |
ENSEMBL Gene Tree for IKBKB (if available)
TreeFam Gene Tree for IKBKB (if available) |
Paralogs
for IKBKB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IKBKB gene
- CHUK2 IKBKE2 TBK12
16 SIMAP similar genes for IKBKB using alignment to 12 protein entries: IKKB_HUMAN (see all proteins):CHUK PKN2 RPS6KA2 PNCK PRKCH PRKD3
MARK4 DKFZp564L2416 NEK9 PAK2 DAPK1 MAPK14
NUAK1 STK25 STK36 TYK2
IKBKB for paralogs About GeneDecksing
|
Genomic Variants
for IKBKB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IKBKB (42128820 - 42190171 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for IKBKB
3 CNVs: 22605 23046 6614
1 Indel: 28929 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IKBKB |
|
Disorders
/ Diseases
for IKBKB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IKBKB for disorders About GeneDecksing
OMIM gene information: 603258
OMIM disorders: --
20/63  diseases for IKBKB (see all 63): About MalaCardshuman t-cell leukemia virus type 1 duchenne muscular dystrophy non-hodgkin lymphoma muscular dystrophy
insulin resistance myeloid leukemia hodgkin's lymphoma rheumatoid arthritis
chronic lymphocytic leukemia chronic myeloid leukemia acute myeloid leukemia herpes simplex
fanconi's anemia lymphocytic leukemia skin disease cutaneous t cell lymphoma
bronchiolitis leukemia renal cell carcinoma cystic fibrosis
10/31 Novoseek disease relationships for IKBKB gene (see all 31) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
70.8 |
40 |
11054378 (2), 9710600 (1), 16085647 (1), 9346485 (1) (see all 34) |
| leukemia t-cell |
57.7 |
2 |
9632633 (1), 10648602 (1) |
| tumors |
56.6 |
61 |
11054378 (2), 19818716 (2), 15492250 (2), 9710600 (1) (see all 45) |
| inflammation |
52.3 |
22 |
16517756 (3), 15731493 (2), 16002568 (2), 14704736 (1) (see all 15) |
| cancer |
42.4 |
16 |
15617879 (2), 18702457 (2), 11520600 (1), 16175180 (1) (see all 12) |
| insulin resistance |
33 |
15 |
18240344 (3), 15617879 (2), 15351728 (2), 12021247 (1) (see all 9) |
| rheumatoid arthritis |
23.2 |
7 |
12847684 (2), 11160335 (1), 15316093 (1), 17067557 (1) |
| shock |
19.1 |
3 |
18282612 (1), 16309849 (1), 16424045 (1) |
| breast cancer |
13.7 |
14 |
19526344 (4), 17016640 (2), 15084260 (1), 16357145 (1) (see all 9) |
| bacterial infections |
7.76 |
1 |
9819420 (1) |
Genetic Association Database (GAD): IKBKB
Human Genome Epidemiology (HuGE) Navigator: IKBKB (20 documents)
Export disorders for IKBKB gene to outside databases
|
Publications
for IKBKB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IKBKB gene, integrated from 9 sources (see all 671):
(articles sorted by number of sources associating them with IKBKB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization. (PubMed id 9763654)1, 2, 3 Shindo M.... Okumura K. (1998)
- Ro52-mediated monoubiquitination of IKK{beta} down-re gulates NF-{kappa}B signalling. (PubMed id 19675099)1, 2, 9 Wada K....Kamitani T. (2009)
- Site-specific monoubiquitination of IkappaB kinase IKKbeta regulates its phosphorylation and persistent activation. (PubMed id 16267042)1, 2, 9 Carter R.S.... Ballard D.W. (2005)
- The IkappaB kinase complex: master regulator of NF-kappaB signaling. (PubMed id 18626576)1, 2, 9 Solt L.A. and May M.J. (2008)
- Activation of IkappaB kinase beta by protein kinase C isoforms. (PubMed id 10022904)1, 2, 9 Lallena M.J....Moscat J. (1999)
- IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes. (PubMed id 9813230)1, 2, 9 Hu M.C.-T. and Wang Y.-P. (1998)
- Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation. (PubMed id 12612076)1, 2, 9 Tegethoff S....Scheidereit C. (2003)
- Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. (PubMed id 10195894)1, 2, 9 Delhase M.... Karin M. (1999)
- FAF1 suppresses IkappaB kinase (IKK) activation by disrupting the IKK complex assembly. (PubMed id 17684021)1, 2, 9 Park M.Y....Kim E. (2007)
- NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF- (kappa)B activation. (PubMed id 15951441)1, 2, 9 Hu W.-H.... Bethea J.R. (2005)
|
External Searches for IKBKB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IKBKB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IKBKB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IKBKB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IKBKB | Pharmacogenomics, SNPs, Pathways | | SeattleSNPs | http://pga.gs.washington.edu/data/ikbkb/ |
|
| | |
About This Section
| Patent Information for IKBKB gene:
Search GeneIP for patents involving IKBKB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IKBKB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for IKBKB | | OriGene shRNA RFP for IKBKB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IKBKB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IKBKB | | | OriGene Protein Over-expression Lysate for IKBKB | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IKBKB | | OriGene 3'-UTR Clone for IKBKB | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IKBKB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IKBKB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for IKBKB | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IKBKB | | OriGene Custom Protein Services for IKBKB | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IKBKB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IKBKB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IKBKB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IKBKB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IKBKB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IKBKB |
| |
 |  |  |  | |
| | Antibodies & Assays for IKBKB (IKK-beta) |
| | | | Tocris compounds for IKBKB |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKBKB |
|  |  |  | | | | ThermoFisher Antibody for IKBKB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKBKB |
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Last full update: 18 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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