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IKBIP Gene

protein-coding   GIFtS: 50
GCID: GC12M099007

IKBKB Interacting Protein

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
IKBKB Interacting Protein1 2     IKBKB-Interacting Protein2 3
IKIP2 3 5     IKK-Interacting Protein2 3
I Kappa B Kinase Interacting Protein1 2     IKK Interacting Protein2
I Kappa-B Kinase-Interacting Protein2 3     Inhibitor Of Nuclear Factor Kappa-B Kinase-Interacting Protein2

External Ids:    HGNC: 264301   Entrez Gene: 1214572   Ensembl: ENSG000001661307   OMIM: 6098615   UniProtKB: Q70UQ03   

Export aliases for IKBIP gene to outside databases

Previous GC identifers: GC12M097531 GC12M096068


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IKBIP Gene:
IKBIP (IKBKB interacting protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: IKIP_HUMAN, Q70UQ0
Function: Target of p53/TP53 with pro-apoptotic function




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for IKBIP
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIKBIP promoter sequence
   Search Chromatin IP Primers for IKBIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IKBIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.1   Ensembl cytogenetic band:  12q23.1   HGNC cytogenetic band: 12q23.1

IKBIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IKBIP gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M099007:  view genomic region     (about GC identifiers)

Start:
99,007,182 bp from pter      End:
99,038,891 bp from pter
Size:
31,710 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IKIP_HUMAN, Q70UQ0 (See protein sequence)
Recommended Name: Inhibitor of nuclear factor kappa-B kinase-interacting protein  
Size: 350 amino acids; 39309 Da
Miscellaneous: Shares a common promoter with APAF1 from which the 2 genes are transcribed in opposite directions
Secondary accessions: Q6ZWH4 Q70UP9 Q86V91 Q96ND2
Alternative splicing: 4 isoforms:  Q70UQ0-1   Q70UQ0-2   Q70UQ0-3   Q70UQ0-4   (Variant in position: 122:Q->H (in dbSNP:rs12322444))

Explore the universe of human proteins at neXtProt for IKBIP: NX_Q70UQ0

Explore proteomics data for IKBIP at MOPED

Post-translational modifications: 

  • Isoform 4 may be phosphorylated at Thr-362 by similarity with mouse isoform 11
  • N-glycosylated. Isoform 4 is glycosylated at Asn-1541
  • Glycosylation2 at Asn144, Asn328
  • Modification sites at PhosphoSitePlus

  • See IKBIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_710154.1  NP_963906.1  NP_963907.1  

    ENSEMBL proteins: 
     ENSP00000376762   ENSP00000343471   ENSP00000299157   ENSP00000398023  

    IKBIP Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for IKBIP

     
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    antibodies-online proteins for IKBIP (5 products) 

     
    antibodies-online peptides for IKBIP

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    antibodies-online antibodies for IKBIP (24 products) 

    IKBIP Assay Products:

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    Cloud-Clone Corp. CLIAs for IKBIP
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    antibodies-online kits for IKBIP (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR024152 Inh_kappa-B_kinase-int

    Graphical View of Domain Structure for InterPro Entry Q70UQ0

    ProtoNet protein and cluster: Q70UQ0


    Find genes that share domains with IKBIP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IKIP_HUMAN, Q70UQ0
    Function: Target of p53/TP53 with pro-apoptotic function
    Induction: By X-ray irradiation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15389287
         
    Find genes that share ontologies with IKBIP           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for IKBIP:
     Cell division defect  Increased 8N DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IKBIP

    miRNA
    Products:
        
    miRTarBase miRNAs that target IKBIP:
    hsa-mir-30a-5p (MIRT028670), hsa-mir-124-3p (MIRT023080), hsa-mir-155-5p (MIRT005251), hsa-mir-186-5p (MIRT045247), hsa-mir-320a (MIRT044660)

    Block miRNA regulation of human, mouse, rat IKBIP using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidIKBIP 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat IKBIP

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKBIP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IKIP_HUMAN, Q70UQ0: Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Isoform 4 deletion of the
    hydrophobic, or transmembrane region between AA 45-63 results in uniform distribution throughout the cell,
    suggesting that this region is responsible for endoplasmic reticulum localization
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus2
    plasma membrane2
    cytosol1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA15389287
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with IKBIP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including IKBIP: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IKBIP

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for IKBIP (Q70UQ03 ENSP000002991574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKBO149203I2D: score=1 
    TRAF2Q129333I2D: score=1 
    VCLP182063I2D: score=1 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010165response to X-ray TAS15389287

    Find genes that share ontologies with IKBIP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IKBIP (IKIP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IKBIP gene (3 alternative transcripts): 
    NM_153687.3  NM_201612.2  NM_201613.2  

    Unigene Cluster for IKBIP:

    IKBKB interacting protein
    Hs.252543  [show with all ESTs]
    Unigene Representative Sequence: NM_153687
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393042 ENST00000342502(uc001tfv.3) ENST00000299157(uc001tfx.3)
    ENST00000420861(uc001tfw.3)
    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IKBIP
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat IKBIP
      QuantiFast Probe-based Assays in human, mouse, rat IKBIP

    Additional mRNA sequence: 

    AJ539425.1 AJ539426.1 AJ539427.1 AK055613.1 AK123069.1 BC029415.1 BC051372.1 BC058933.1 
    BC107572.1 

    5 DOTS entries:

    DT.95366821  DT.100719480  DT.210307  DT.100777246  DT.75113023 

    Selected AceView cDNA sequences (see all 123):

    CB268650 AI240164 BF509630 BQ020440 AI289288 BC058933 BP431752 BQ422086 
    AI560995 CR622083 AA568924 BM468651 AI753709 AJ539425 AI857461 AI253732 
    AJ539427 NM_201613 CA312525 CA420322 AI167992 AK123069 NM_201614 CN481429 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IKBIP    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4
    SP1:                          -         
    SP2:                                    
    SP3:                    -     -         


    ECgene alternative splicing isoforms for IKBIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IKBIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAGACTGG
    IKBIP Expression
    About this image


    IKBIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    IKBIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IKBIP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.252543

    UniProtKB/Swiss-Prot: IKIP_HUMAN, Q70UQ0
    Tissue specificity: Expressed in vein endothelial cells. Isoform 4 is expressed in lung, kidney, spleen, thymus
    and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including IKBIP: 
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKBIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IKBIP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ikbip1 , 5 IKBKB interacting protein1, 5 80.67(n)1
    79.13(a)1
      10 (45.54 cM)5
    674541  NM_026166.21  NP_080442.21 
     910829405 
    chicken
    (Gallus gallus)
    Aves IKBIP1 IKBKB interacting protein 65.12(n)
    53.68(a)
      417925  XM_416166.4  XP_416166.1 
    lizard
    (Anolis carolinensis)
    Reptilia IKBIP6
    IKBKB interacting protein
    51(a)
    1 ↔ 1
    5(29308746-29315699)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.172432 Xenopus laevis transcribed sequence 70.83(n)    BM261999.1 
    zebrafish
    (Danio rerio)
    Actinopterygii IKBIP6
    IKBKB interacting protein
    12(a)
    1 ↔ 1
    4(62041878-62059140) ENSDARG00000078520


    ENSEMBL Gene Tree for IKBIP (if available)
    TreeFam Gene Tree for IKBIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IKBIP gene
    1 SIMAP similar gene for IKBIP using alignment to 1 protein entry:     IKIP_HUMAN:
    IKIP

    Find genes that share paralogs with IKBIP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IKBIP (see all 641)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1914277321,2
    --99006740(+) AGAACA/GGTGAG 2 -- int10--------
    rs1834348431,2
    --99006780(+) AAGTTC/TTTGCT 2 -- int10--------
    rs1879743381,2
    --99006791(+) ATACTA/GTTATA 2 -- int10--------
    rs1164793771,2
    C,F--99006797(+) TTATAC/AACCAG 2 -- int11Minor allele frequency- A:0.03WA 118
    rs1453819031,2
    --99006823(+) ACACTA/GCTGTT 2 -- int10--------
    rs1915417951,2
    --99006849(+) TAAAGC/TCATGA 2 -- int10--------
    rs1488000891,2
    --99006868(+) GATAGG/TCTTTT 2 -- int10--------
    rs352248591,2
    C--99007086(+) TCCTA-/T/TG  
            
    GTGTG
    2 -- int10--------
    rs1459541161,2
    C--99007126(+) TGGGT-/AACAACAT 2 -- int10--------
    rs772586391,2
    C,F--99007218(+) ACCTGT/CTTTAA 2 -- ut311Minor allele frequency- C:0.02NA 120

    HapMap Linkage Disequilibrium report for IKBIP (99007182 - 99038891 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IKBIP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659532CNV Deletion23128226
    nsv819940CNV Loss19587683
    nsv7234OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): IKBIP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IKBIP
    DNA2.0 Custom Variant and Variant Library Synthesis for IKBIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609861    OMIM disorders: --


    Find genes that share disorders with IKBIP           About GenesLikeMe


    Export disorders for IKBIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IKBIP gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with IKBIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53. (PubMed id 15389287)1, 2, 3, 9 Hofer-Warbinek R.... de Martin R. (Cell Death Differ. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 121457 HGNC: 26430 AceView: IKIP Ensembl:ENSG00000166130 euGenes: HUgn121457
    ECgene: IKBIP H-InvDB: IKBIP

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IKBIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IKBIP gene:
    Search GeneIP for patents involving IKBIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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