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Aliases for IKBIP Gene

Aliases for IKBIP Gene

  • IKBKB Interacting Protein 2 3 5
  • I Kappa B Kinase Interacting Protein 2 3
  • I Kappa-B Kinase-Interacting Protein 3 4
  • IKBKB-Interacting Protein 3 4
  • IKK-Interacting Protein 3 4
  • IKIP 3 4
  • IKK Interacting Protein 3

External Ids for IKBIP Gene

Previous GeneCards Identifiers for IKBIP Gene

  • GC12M097531
  • GC12M099007
  • GC12M096068

Summaries for IKBIP Gene

GeneCards Summary for IKBIP Gene

IKBIP (IKBKB Interacting Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IKBIP Gene

  • Target of p53/TP53 with pro-apoptotic function.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IKBIP Gene

Genomics for IKBIP Gene

Regulatory Elements for IKBIP Gene

Promoters for IKBIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IKBIP on UCSC Golden Path with GeneCards custom track

Genomic Location for IKBIP Gene

Chromosome:
12
Start:
98,613,404 bp from pter
End:
98,645,113 bp from pter
Size:
31,710 bases
Orientation:
Minus strand

Genomic View for IKBIP Gene

Genes around IKBIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IKBIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IKBIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IKBIP Gene

Proteins for IKBIP Gene

  • Protein details for IKBIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70UQ0-IKIP_HUMAN
    Recommended name:
    Inhibitor of nuclear factor kappa-B kinase-interacting protein
    Protein Accession:
    Q70UQ0
    Secondary Accessions:
    • Q6ZWH4
    • Q70UP9
    • Q86V91
    • Q96ND2

    Protein attributes for IKBIP Gene

    Size:
    350 amino acids
    Molecular mass:
    39309 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Shares a common promoter with APAF1 from which the 2 genes are transcribed in opposite directions.

    Alternative splice isoforms for IKBIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IKBIP Gene

Proteomics data for IKBIP Gene at MOPED

Post-translational modifications for IKBIP Gene

  • Isoform 4 may be phosphorylated at Thr-362 by similarity with mouse isoform 1.
  • N-glycosylated. Isoform 4 is glycosylated at Asn-154.
  • Glycosylation at Asn 144 and Asn 328
  • Modification sites at PhosphoSitePlus

Other Protein References for IKBIP Gene

No data available for DME Specific Peptides for IKBIP Gene

Domains & Families for IKBIP Gene

Protein Domains for IKBIP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IKBIP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IKBIP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for IKBIP Gene

Function for IKBIP Gene

Molecular function for IKBIP Gene

UniProtKB/Swiss-Prot Function:
Target of p53/TP53 with pro-apoptotic function.
UniProtKB/Swiss-Prot Induction:
By X-ray irradiation.

Phenotypes for IKBIP Gene

genes like me logo Genes that share phenotypes with IKBIP: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IKBIP Gene

Localization for IKBIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IKBIP Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Isoform 4 deletion of the hydrophobic, or transmembrane region between AA 45-63 results in uniform distribution throughout the cell, suggesting that this region is responsible for endoplasmic reticulum localization.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IKBIP Gene COMPARTMENTS Subcellular localization image for IKBIP gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
nucleus 2
plasma membrane 2
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IKBIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with IKBIP: view

Pathways & Interactions for IKBIP Gene

SuperPathways for IKBIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for IKBIP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IKBIP Gene

Drugs & Compounds for IKBIP Gene

No Compound Related Data Available

Transcripts for IKBIP Gene

Unigene Clusters for IKBIP Gene

IKBKB interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IKBIP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4
SP1: -
SP2:
SP3: - -

Relevant External Links for IKBIP Gene

GeneLoc Exon Structure for
IKBIP
ECgene alternative splicing isoforms for
IKBIP

Expression for IKBIP Gene

mRNA expression in normal human tissues for IKBIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IKBIP Gene

This gene is overexpressed in Bone (21.9) and Bone marrow stromal cell (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IKBIP Gene



SOURCE GeneReport for Unigene cluster for IKBIP Gene Hs.252543

mRNA Expression by UniProt/SwissProt for IKBIP Gene

Q70UQ0-IKIP_HUMAN
Tissue specificity: Expressed in vein endothelial cells. Isoform 4 is expressed in lung, kidney, spleen, thymus and skeletal muscle.
genes like me logo Genes that share expression patterns with IKBIP: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for IKBIP Gene

Orthologs for IKBIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for IKBIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IKBIP 35
  • 99.56 (n)
  • 98.94 (a)
IKBIP 36
  • 37 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IKBIP 36
  • 33 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IKBIP 36
  • 89 (a)
OneToOne
IKBIP 35
  • 90.93 (n)
  • 89.07 (a)
mouse
(Mus musculus)
Mammalia Ikbip 36
  • 77 (a)
OneToOne
Ikbip 16
Ikbip 35
  • 80.67 (n)
  • 79.13 (a)
oppossum
(Monodelphis domestica)
Mammalia IKBIP 36
  • 31 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IKBIP 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ikbip 35
  • 82.29 (n)
  • 81.03 (a)
chicken
(Gallus gallus)
Aves IKBIP 36
  • 54 (a)
OneToOne
IKBIP 35
  • 65.12 (n)
  • 53.68 (a)
lizard
(Anolis carolinensis)
Reptilia IKBIP 36
  • 51 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17243 35
zebrafish
(Danio rerio)
Actinopterygii IKBIP 36
  • 12 (a)
OneToOne
Species with no ortholog for IKBIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IKBIP Gene

ENSEMBL:
Gene Tree for IKBIP (if available)
TreeFam:
Gene Tree for IKBIP (if available)

Paralogs for IKBIP Gene

(1) SIMAP similar genes for IKBIP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IKBIP: view

No data available for Paralogs for IKBIP Gene

Variants for IKBIP Gene

Sequence variations from dbSNP and Humsavar for IKBIP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1048906 - 98,613,845(-) TAGAA(A/G)GTGAC reference, missense, utr-variant-3-prime
rs1055656 -- 98,625,691(-) AAACA(A/G)GATAC intron-variant, utr-variant-3-prime
rs2055306 -- 98,614,997(-) CTGGA(A/G)GAAAC intron-variant
rs2372394 -- 98,638,802(+) ttgtt(C/T)gtttt intron-variant
rs7138837 -- 98,621,843(+) gaggc(C/T)gaggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IKBIP Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
esv2659532 CNV Deletion 23128226
nsv819940 CNV Loss 19587683

Variation tolerance for IKBIP Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.69; 57.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IKBIP Gene

HapMap Linkage Disequilibrium report
IKBIP
Human Gene Mutation Database (HGMD)
IKBIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IKBIP Gene

Disorders for IKBIP Gene

Relevant External Links for IKBIP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IKBIP

No disorders were found for IKBIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IKBIP Gene

Publications for IKBIP Gene

  1. A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53. (PMID: 15389287) Hofer-Warbinek R. … de Martin R. (Cell Death Differ. 2004) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  5. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3

Products for IKBIP Gene

Sources for IKBIP Gene

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