IKBIP Gene
protein-coding GIFtS: 47
GCID: GC12M099007
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IKBKB interacting protein
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Aliases
for IKBIP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| IKBKB Interacting Protein1 2 | | FLJ310511 | | IKIP1 2 3 5 | | I Kappa B Kinase Interacting Protein2 | | I Kappa-B Kinase-Interacting Protein2 3 | | IKK Interacting Protein2 | | IKBKB-Interacting Protein2 3 | | Inhibitor Of Nuclear Factor Kappa-B Kinase-Interacting Protein2 | | IKK-Interacting Protein2 3 | | |
Export aliases for IKBIP gene to outside databasesPrevious GC identifers: GC12M097531 GC12M096068 |
Summaries
for IKBIP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: IKIP_HUMAN, Q70UQ0Function: Target of p53/TP53 with pro-apoptotic function
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Genomic Views
for IKBIP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for IKBIP
Other transcription factors
Search SABiosciences Chromatin IP Primers for IKBIP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IKBIP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q23.1 Ensembl cytogenetic band: 12q23.1 HGNC cytogenetic band: 12q23.1IKBIP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M099007: view genomic region
(about GC identifiers)
Start:
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99,007,182 bp from pter |
End:
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99,038,891 bp from pter |
Size:
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31,710 bases |
Orientation:
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minus strand |
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Proteins
for IKBIP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IKIP_HUMAN, Q70UQ0 (See
protein sequence)Recommended Name: Inhibitor of nuclear factor kappa-B kinase-interacting protein Size: 350 amino acids; 39309 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Isoform 4 deletion of thehydrophobic, or transmembrane region between AA 45-63 results in uniform distribution throughout the cell, suggestingthat this region is responsible for endoplasmic reticulum localization
Miscellaneous: Shares a common promoter with APAF1 from which the 2 genes are transcribed in opposite directions
Secondary accessions: Q6ZWH4 Q70UP9 Q86V91 Q96ND2Alternative splicing: 4 isoforms: Q70UQ0-1 Q70UQ0-2 Q70UQ0-3 Q70UQ0-4 (Variant in position: 122:Q->H (in dbSNP:rs12322444))Explore the universe of human proteins at neXtProt for IKBIP: NX_Q70UQ0
Post-translational modifications:
Isoform 4 may be phosphorylated at Thr-362 by similarity with mouse isoform 11
N-glycosylated. Isoform 4 is glycosylated at Asn-1541
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q70UQ0
IKBIP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_710154.1 NP_963906.1 NP_963907.1
ENSEMBL proteins: ENSP00000376762 ENSP00000343471 ENSP00000299157 ENSP00000398023
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
IKBIP for ontologies About GeneDecksing
IKBIP Antibody Products:
Assay Products for IKBIP: |
Protein
Domains /
Families
for IKBIP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IKBIP for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q70UQ0ProtoNet protein and cluster: Q70UQ0 |
Function
for IKBIP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IKIP_HUMAN, Q70UQ0Function: Target of p53/TP53 with pro-apoptotic functionInduction: By X-ray irradiation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IKBIP (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IKBIP (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 3): IKBIP (NM_153687) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IKBIP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKBIP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKBIP |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
IKBIP for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for IKBIP:
|
Pathways & Interactions
for IKBIP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IKBIP
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
4 Interacting proteins for IKBIP (Q70UQ03 ENSP000002991574) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
IKBIP for ontologies About GeneDecksing
|
Drugs & Compounds
for IKBIP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IKBIP
Search CenterWatch for drugs/clinical trials and news about IKBIP / IKIP
|
Transcripts
for IKBIP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IKBIP gene (3 alternative transcripts): NM_153687.3 NM_201612.2 NM_201613.2 Unigene Cluster for IKBIP: IKBKB interacting protein Hs.252543 [show with all ESTs]Unigene Representative Sequence: NM_1536874 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000393042 ENST00000342502(uc001tfv.3) ENST00000299157(uc001tfx.3)
ENST00000420861(uc001tfw.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IKBIP (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IKBIP (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): IKBIP (NM_153687) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IKBIP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKBIP |
Additional cDNA sequence: AJ539425.1 AJ539426.1 AJ539427.1 AK055613.1 AK123069.1 BC029415.1 BC051372.1 BC058933.1 BC107572.1 5 DOTS entries: DT.95366821 DT.100719480 DT.210307 DT.100777246 DT.75113023 24/123 AceView cDNA sequences (see all 123): BU543522 BM468651 AI253732 AI753709 CN481429 AJ539427 CR622083 AA568924 NM_201614 AI240164 CA420322 BP431752 AI167992 AK123069 AI560995 AJ539425 CA312525 BC058933 AJ539426 NM_201613 BQ020440 NM_201612 CB268650 AI289288
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for IKBIP About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 |
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| SP1: | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | |
ECgene alternative splicing isoforms for IKBIP
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Expression
for IKBIP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IKBIP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAGACTGG
About this image
See IKBIP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IKBIP
SOURCE GeneReport for Unigene cluster: Hs.252543
UniProtKB/Swiss-Prot: IKIP_HUMAN, Q70UQ0Tissue specificity: Expressed in vein endothelial cells. Isoform 4 is expressed in lung, kidney, spleen, thymus andskeletal muscle
SABiosciences Expression via Pathway-Focused PCR Array including IKBIP:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IKBIP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IKBIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IKBIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IKBIP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKBIP |
Orthologs
for IKBIP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IKBIP gene from 4/9 species (see all 9) About this table
ENSEMBL Gene Tree for IKBIP (if available)
TreeFam Gene Tree for IKBIP (if available) |
Paralogs
for IKBIP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IKBIP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IKBIP (99007182 - 99038891 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for IKBIP
1 CNV: 58607
Human Gene Mutation Database (HGMD): IKBIP
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IKBIP |
|
Disorders
/ Diseases
for IKBIP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 IKBIP for disorders About MalaCards
IKBIP for disorders About GeneDecksing
OMIM gene information: 609861
OMIM disorders: --
Export disorders for IKBIP gene to outside databases
|
Publications
for IKBIP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IKBIP gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with IKBIP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53. (PubMed id 15389287)1, 2, 3, 9 Hofer-Warbinek R.... de Martin R. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Proteomic identification of common SCF ubiquitin ligas e FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
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External Searches for IKBIP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IKBIP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IKBIP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IKBIP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IKBIP | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for IKBIP gene:
Search GeneIP for patents involving IKBIP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IKBIP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IKBIP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IKBIP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IKBIP | | | OriGene Protein Over-expression Lysate for IKBIP | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IKBIP | | OriGene 3'-UTR Clone for IKBIP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IKBIP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IKBIP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for IKBIP | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IKBIP | | OriGene Custom Protein Services for IKBIP | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IKBIP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IKBIP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IKBIP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IKBIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IKBIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IKBIP |
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| | | | Search Tocris compounds for IKBIP |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IKBIP |
|  |  |  | | | | Search ThermoFisher Antibodies for IKBIP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IKBIP |
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