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Aliases for IK Gene

Aliases for IK Gene

  • IK Cytokine, Down-Regulator Of HLA II 2 3 5
  • Cytokine IK 3 4
  • IK Factor 3 4
  • RED 3 4
  • Chondrosarcoma-Associated Protein 2 3
  • Prer Protein 3
  • Protein RER 4
  • RD Element 3
  • CSA2 3
  • RER 4

External Ids for IK Gene

Previous GeneCards Identifiers for IK Gene

  • GC05P139843
  • GC05P140610
  • GC05P140009
  • GC05P140055
  • GC05P139992
  • GC05P139993
  • GC05P140007
  • GC05P140028
  • GC05P135173
  • GC05P141198
  • GC05P141473

Summaries for IK Gene

Entrez Gene Summary for IK Gene

  • The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for IK Gene

IK (IK Cytokine, Down-Regulator Of HLA II) is a Protein Coding gene. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for IK Gene

  • May bind to chromatin.

Gene Wiki entry for IK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IK Gene

Genomics for IK Gene

Regulatory Elements for IK Gene

Enhancers for IK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IK on UCSC Golden Path with GeneCards custom track

Promoters for IK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IK on UCSC Golden Path with GeneCards custom track

Genomic Location for IK Gene

140,647,058 bp from pter
140,662,480 bp from pter
15,423 bases
Plus strand

Genomic View for IK Gene

Genes around IK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IK Gene

Proteins for IK Gene

  • Protein details for IK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Red
    Protein Accession:
    Secondary Accessions:
    • Q6IPD8

    Protein attributes for IK Gene

    557 amino acids
    Molecular mass:
    65602 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IK Gene

Proteomics data for IK Gene at MOPED

Post-translational modifications for IK Gene

  • Ubiquitination at Lys 164, Lys 173, and Lys 260
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for IK Gene

Domains & Families for IK Gene

Protein Domains for IK Gene


Suggested Antigen Peptide Sequences for IK Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RED family.
  • Belongs to the RED family.
genes like me logo Genes that share domains with IK: view

No data available for Gene Families for IK Gene

Function for IK Gene

Molecular function for IK Gene

GENATLAS Biochemistry:
cytokine IK (19kDa) downregulating HLA class II expression on the cell surface
UniProtKB/Swiss-Prot Function:
May bind to chromatin.
genes like me logo Genes that share phenotypes with IK: view

Animal Model Products

miRNA for IK Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IK Gene

Localization for IK Gene

Subcellular locations from UniProtKB/Swiss-Prot for IK Gene


Subcellular locations from

Jensen Localization Image for IK Gene COMPARTMENTS Subcellular localization image for IK gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 2
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for IK Gene

Pathways & Interactions for IK Gene

SuperPathways for IK Gene

No Data Available

Gene Ontology (GO) - Biological Process for IK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling TAS 7970704
genes like me logo Genes that share ontologies with IK: view

No data available for Pathways by source and SIGNOR curated interactions for IK Gene

Drugs & Compounds for IK Gene

No Compound Related Data Available

Transcripts for IK Gene

Unigene Clusters for IK Gene

IK cytokine, down-regulator of HLA II:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IK Gene

No ASD Table

Relevant External Links for IK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IK Gene

mRNA expression in normal human tissues for IK Gene

Protein differential expression in normal tissues from HIPED for IK Gene

This gene is overexpressed in Adrenal (14.1), Peripheral blood mononuclear cells (13.0), and Blymphocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IK Gene

SOURCE GeneReport for Unigene cluster for IK Gene Hs.421245

mRNA Expression by UniProt/SwissProt for IK Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with IK: view

Protein tissue co-expression partners for IK Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for IK Gene

Orthologs for IK Gene

This gene was present in the common ancestor of animals.

Orthologs for IK Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IK 35
  • 91.83 (n)
  • 98.2 (a)
IK 36
  • 99 (a)
(Canis familiaris)
Mammalia IK 35
  • 91.65 (n)
  • 97.99 (a)
(Mus musculus)
Mammalia Ik 35
  • 90.84 (n)
  • 98.38 (a)
Ik 16
Ik 36
  • 98 (a)
(Pan troglodytes)
Mammalia IK 35
  • 99.76 (n)
  • 99.82 (a)
(Rattus norvegicus)
Mammalia Ik 35
  • 90.31 (n)
  • 98.56 (a)
(Ornithorhynchus anatinus)
Mammalia IK 36
  • 92 (a)
(Gallus gallus)
Aves IK 35
  • 83.91 (n)
  • 94.58 (a)
IK 36
  • 95 (a)
(Anolis carolinensis)
Reptilia IK 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11062 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24451 35
(Danio rerio)
Actinopterygii ik 35
  • 75.56 (n)
  • 84.28 (a)
wufb54c03 35
ik 36
  • 85 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.755 35
fruit fly
(Drosophila melanogaster)
Insecta CG18005 37
  • 64 (a)
beag 35
  • 57.77 (n)
  • 57.93 (a)
CG18005 36
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004738 35
  • 58.55 (n)
  • 59.95 (a)
(Caenorhabditis elegans)
Secernentea smu-2 36
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10369 36
  • 52 (a)
Species with no ortholog for IK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IK Gene

Gene Tree for IK (if available)
Gene Tree for IK (if available)

Paralogs for IK Gene Pseudogenes for IK Gene

genes like me logo Genes that share paralogs with IK: view

No data available for Paralogs for IK Gene

Variants for IK Gene

Sequence variations from dbSNP and Humsavar for IK Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs4801 -- 140,662,375(+) CCCAC(G/T)GTTTT utr-variant-3-prime
rs778595 -- 140,657,096(+) tactc(A/G)gaagg intron-variant
rs778596 -- 140,657,687(+) GAGAA(A/G)CCTTA intron-variant
rs778597 -- 140,661,080(+) AGTAA(A/G)CAAGC intron-variant
rs778598 -- 140,661,336(+) CCAAG(C/T)TCTTT intron-variant

Variation tolerance for IK Gene

Residual Variation Intolerance Score: 29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.31% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for IK Gene

Disorders for IK Gene

Relevant External Links for IK

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IK Gene

Publications for IK Gene

  1. A new cytokine (IK) down-regulating HLA class II: monoclonal antibodies, cloning and chromosome localization. (PMID: 7970704) Krief P. … Azzarone B. (Oncogene 1994) 2 3 4 23 67
  2. Implication of a new molecule IK in CD34+ hematopoietic progenitor cell proliferation and differentiation. (PMID: 9160666) Cao L.X. … Krief P. (Blood 1997) 3 23
  3. Low-dose photon irradiation alters cell differentiation via activation of hIK channels. (PMID: 25277267) Roth B. … Thiel G. (Pflugers Arch. 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for IK Gene

Sources for IK Gene