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IK Gene

protein-coding   GIFtS: 58
GCID: GC05P140028

IK Cytokine, Down-Regulator Of HLA II

  See IK-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
IK Cytokine, Down-Regulator Of HLA II1 2     Prer Protein2
RED2 3 5     Protein Red2
Cytokine IK2 3     RD Element2
IK Factor2 3     RER3
CSA22     Protein RER3
Chondrosarcoma-Associated Protein 22     

External Ids:    HGNC: 59581   Entrez Gene: 35502   Ensembl: ENSG000001131417   OMIM: 6005495   UniProtKB: Q131233   
ORGUL members:         

Export aliases for IK gene to outside databases

Previous GC identifers: GC05P139843 GC05P140610 GC05P140009 GC05P140055 GC05P139992 GC05P139993 GC05P140007 GC05P135173


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IK Gene:
The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid
and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus.
Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2.
(provided by RefSeq, Jul 2008)

GeneCards Summary for IK Gene:
IK (IK cytokine, down-regulator of HLA II) is a protein-coding gene. Diseases associated with IK include central sleep apnea. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot: RED_HUMAN, Q13123
Function: May bind to chromatin

Gene Wiki entry for IK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the IK gene promoter:
         CREB   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIK promoter sequence
   Search Chromatin IP Primers for IK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.3   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q31.3

IK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IK gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P140028:  view genomic region     (about GC identifiers)

Start:
140,026,643 bp from pter      End:
140,042,065 bp from pter
Size:
15,423 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RED_HUMAN, Q13123 (See protein sequence)
Recommended Name: Protein Red  
Size: 557 amino acids; 65602 Da
Developmental stage: Expressed at similar levels in fetal and adult tissues
Caution: Was originally (PubMed:7970704) thought to be the IK factor, a cytokine involved in the negative
regulatory pathway of constitutive MHC class II antigens expression
Secondary accessions: Q6IPD8

Explore the universe of human proteins at neXtProt for IK: NX_Q13123

Explore proteomics data for IK at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys164, Lys173, Lys260
  • Modification sites at PhosphoSitePlus

  • See IK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006074.2  
    ENSEMBL proteins: 
     ENSP00000425564   ENSP00000396301   ENSP00000421930   ENSP00000424622   ENSP00000422641  
     ENSP00000426764  

    IK Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for IK
    OriGene Custom MassSpec
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    Novus Biologicals IK Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IK

     
    Search eBioscience for Proteins for IK 

     
    antibodies-online proteins for IK (3 products) 

     
    Search antibodies-online for peptides for IK

    IK Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for IK
    Cloud-Clone Corp. Antibodies for IK
    ThermoFisher Antibodies for IK
    antibodies-online antibodies for IK (8 products) 

    IK Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IK
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IK
    Cloud-Clone Corp. CLIAs for IK
    Search eBioscience for ELISAs for IK 
    antibodies-online kits for IK (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR012916 RED_N
     IPR012492 RED_C

    Graphical View of Domain Structure for InterPro Entry Q13123

    ProtoNet protein and cluster: Q13123

    1 Blocks protein domain: IPB012492 RED-like

    UniProtKB/Swiss-Prot: RED_HUMAN, Q13123
    Similarity: Belongs to the RED family


    Find genes that share domains with IK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RED_HUMAN, Q13123
    Function: May bind to chromatin

         Genatlas biochemistry entry for IK:
    cytokine IK (19kDa) downregulating HLA class II expression on the cell surface

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0042802identical protein binding IPI--
         
    Find genes that share ontologies with IK           About GenesLikeMe


    Phenotypes:
         8 GenomeRNAi human phenotypes for IK:
     Cell cycle / mitosis defect  Cell division defect  Decreased cell number, increas  Decreased influenza A/WSN/33 r 
     Decreased viability after Chla  Increased gamma-H2AX phosphory  Increased number of cells in m  Increased number of mitotic ce 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IK

    miRNA
    Products:
        
    miRTarBase miRNAs that target IK:
    hsa-mir-92a-3p (MIRT048953), hsa-mir-92b-3p (MIRT040554), hsa-mir-34a-5p (MIRT025539)

    Block miRNA regulation of human, mouse, rat IK using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate IK:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidIK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IK
    Predesigned siRNA for gene silencing in human, mouse, rat IK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IK

    Clone
    Products:
         
    OriGene clones in human, mouse for IK (see all 7)
    OriGene ORF clones in mouse, rat for IK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IK (NM_001197)
    Sino Biological Human cDNA Clone for IK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IK

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IK
    Browse ESI BIO Cell Lines and PureStem Progenitors for IK 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RED_HUMAN, Q13123: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS7970704
    GO:0005634nucleus IEA--

    Find genes that share ontologies with IK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including IK: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for IK (Q131231, 2, 3 ENSP000003963014) via UniProtKB, MINT, STRING, and/or I2D (see all 613)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF6O949061, 2, ENSP000002660794EBI-713456,EBI-536755 MINT-7945693 MINT-8331778 MINT-8336144 STRING: ENSP00000266079
    EFTUD2Q150291, 2EBI-713456,EBI-357897 MINT-8331910 MINT-7945693 MINT-8336111
    FRA10AC1Q70Z531, 2, ENSP000003604884EBI-713456,EBI-710176 MINT-8332273 MINT-8337508 STRING: ENSP00000360488
    MFAP1P550811, 2, ENSP000002678124EBI-713456,EBI-1048159 MINT-8332251 MINT-8337409 STRING: ENSP00000267812
    SMU1Q2TAY71, 2, ENSP000003803364EBI-713456,EBI-298027 MINT-8331888 MINT-8337486 STRING: ENSP00000380336
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS7970704
    GO:0007267cell-cell signaling TAS7970704

    Find genes that share ontologies with IK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IK (RED)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IK gene: 
    NM_006083.3  

    Unigene Cluster for IK:

    IK cytokine, down-regulator of HLA II
    Hs.421245  [show with all ESTs]
    Unigene Representative Sequence: AK225924
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513256 ENST00000417647(uc011czk.1 uc003lgq.3 uc021yen.1)
    ENST00000503332 ENST00000507593 ENST00000508301 ENST00000523672 ENST00000502899
    ENST00000512827 ENST00000515015 ENST00000515592
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IK using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate IK:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidIK 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IK
    Predesigned siRNA for gene silencing in human, mouse, rat IK
    Clone
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    OriGene clones in human, mouse for IK (see all 7)
    OriGene ORF clones in mouse, rat for IK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IK (NM_001197)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IK
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IK
    OriGene qSTAR qPCR primer pairs in human, mouse for IK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IK
      QuantiTect SYBR Green Assays in human, mouse, rat IK
      QuantiFast Probe-based Assays in human, mouse, rat IK

    Additional mRNA sequence: 

    AF182645.1 AJ005579.1 AK225924.1 AK293626.1 AK308730.1 AK312363.1 AL050296.1 AY007094.1 
    BC013005.2 BC051295.1 BC071964.1 S74221.1 

    Selected DOTS entries (see all 32):

    DT.418420  DT.40248441  DT.92459896  DT.100845637  DT.100845634  DT.95170073  DT.121031617  DT.100059633 
    DT.95170088  DT.120833500  DT.120833425  DT.120833416  DT.120833479  DT.95170072  DT.100043123  DT.100845635 
    DT.120833460  DT.120833503  DT.121031572  DT.319462  DT.100839133  DT.100845629  DT.100059632  DT.120833409 

    Selected AceView cDNA sequences (see all 295):

    BG940194 AA531032 CA434842 AI831143 AW238950 BC071964 AA436395 BM726920 
    BU741196 AA953244 CA442072 BQ019101 CA434844 CK299491 BQ102505 AA235321 
    BM806610 BM667779 AW291922 BG149904 AI916319 BF690330 BP378980 BQ100665 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGTGGATA
    IK Expression
    About this image

    IK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.421245

    UniProtKB/Swiss-Prot: RED_HUMAN, Q13123
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including IK: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat IK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IK gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ik1 , 5 IK cytokine1, 5 90.84(n)1
    98.38(a)1
      18 (19.46 cM)5
    240101  NM_011879.21  NP_036009.11 
     367446565 
    chicken
    (Gallus gallus)
    Aves IK1 IK cytokine, down-regulator of HLA II 83.91(n)
    94.58(a)
      416133  NM_001006145.1  NP_001006145.1 
    lizard
    (Anolis carolinensis)
    Reptilia IK6
    IK cytokine, down-regulator of HLA II
    51(a)
    1 ↔ 1
    4(77782860-77809207)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.244512 Xenopus laevis transcribed sequence with moderate similarity more 78.91(n)    CA788138.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb54c032 wufb54c03 78.09(n)   322241  BC049322.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG180053
    beag1
    beag1 64(a)3
    57.77(n)1
    57.93(a)1
      85C43
    410911  NM_141608.31  NP_649865.11 
    worm
    (Caenorhabditis elegans)
    Secernentea smu-26
    Protein SMU-2 (smu-2) mRNA, complete cds
    35(a)
    1 ↔ 1
    II(3482436-3490139) WBGene00004896
    rice
    (Oryza sativa)
    Liliopsida AK072412.12   -- 74.37(n)    AK072412.1 


    ENSEMBL Gene Tree for IK (if available)
    TreeFam Gene Tree for IK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IK gene
    Selected SIMAP similar genes for IK using alignment to 7 protein entries:     RED_HUMAN (see all proteins) (see all similar genes):
    RBP7    DKFZp564B112    CSA2    CALCOCO2    CSPP1    SLC24A1
    TNNT1    C14orf105    TAF2    ARL6IP5    C11orf80    EIF3G
    EIF3K    TMX3    SMYD4    FRG1    LSM12    NDC80

    Find genes that share paralogs with IK           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for IK
    PGOHUM00000240052


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IK (see all 304)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs68607581,2
    C,F--140029373(+) tcggcG/Agccca 1 -- int12Minor allele frequency- A:0.50NA 4
    rs1494810871,2
    --140029393(+) GATTAC/TAGGCG 1 -- int10--------
    rs1877535641,2
    --140029397(+) ACAGGC/TGTGAG 1 -- int10--------
    rs581701521,2
    C,F--140029412(+) TGCGCG/CTGGCC 1 -- int11Minor allele frequency- C:0.50WA 2
    rs1389407861,2
    --140029436(+) TTAAAC/TGCATT 1 -- int10--------
    rs1931131121,2
    --140029471(+) GAAAAC/G/TACAAC 1 -- int10--------
    rs1845480561,2
    --140029547(+) TGCTTA/CTTTTT 1 -- int10--------
    rs1889496531,2
    --140029666(+) TCATCC/TGTGGC 1 -- int10--------
    rs1158484711,2
    F--140029685(+) CACAGT/ATTTAA 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1421627681,2
    --140029708(+) CCACCA/GCTCCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for IK (140026643 - 140042065 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for IK: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IK
    DNA2.0 Custom Variant and Variant Library Synthesis for IK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600549    OMIM disorders: --

    1 disease for IK:    
    About MalaCards
    central sleep apnea

    1 disease from the University of Copenhagen DISEASES database for IK:
    Central sleep apnea

    Find genes that share disorders with IK           About GenesLikeMe

    Genetic Association Database (GAD): IK
    Human Genome Epidemiology (HuGE) Navigator: IK (115 documents)

    Export disorders for IK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IK gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with IK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new cytokine (IK) down-regulating HLA class II: monoclonal antibodies, cloning and chromosome localization. (PubMed id 7970704)1, 2, 3, 9 Krief P.... Azzarone B. (Oncogene 1994)
    2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    3. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. (PubMed id 19845895)1, 4 Koskinen L.L....Saavalainen P. (Tissue Antigens 2009)
    4. Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat. (PubMed id 10216252)1, 2 Assier E.... Rich T. (Gene 1999)
    5. Implication of a new molecule IK in CD34+ hematopoietic progenitor cell proliferation and differentiation. (PubMed id 9160666)1, 9 Cao L.X....Krief P. (Blood 1997)
    6. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    7. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. RED, a spindle pole-associated protein, is required for kinetochore localization of MAD1, mitotic progression, and activation of the spindle assembly checkpoint. (PubMed id 22351768)1 Yeh P.C....Juang Y.L. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3550 HGNC: 5958 AceView: IK.1 Ensembl:ENSG00000113141 euGenes: HUgn3550
    ECgene: IK H-InvDB: IK

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IK gene:
    Search GeneIP for patents involving IK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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