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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGSF9B Gene

protein-coding   GIFtS: 38
GCID: GC11M133785

Immunoglobulin Superfamily, Member 9B

  Search for IGSF9B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Immunoglobulin Superfamily, Member 9B1 2
Immunoglobulin Superfamily Member 9B2 3
Protein Turtle Homolog B2
IgSF9B3
KIAA10303

External Ids:    HGNC: 323261   Entrez Gene: 229972   Ensembl: ENSG000000808547   OMIM: 6137735   UniProtKB: Q9UPX03   

Export aliases for IGSF9B gene to outside databases

Previous GC identifers: GC11M133291 GC11M129739


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IGSF9B Gene: 
IGSF9B (immunoglobulin superfamily, member 9B) is a protein-coding gene. An important paralog of this gene is IGSF9.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IGSF9B gene promoter:
         RREB-1   Brachyury   HNF-4alpha2   Nkx2-5   Tal-1beta   HNF-4alpha1   E47   Hand1   ITF-2   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IGSF9B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGSF9B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q25   Ensembl cytogenetic band:  11q25   HGNC cytogenetic band: 11q25

IGSF9B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGSF9B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M133785:  view genomic region     (about GC identifiers)

Start:
133,778,459 bp from pter      End:
133,826,880 bp from pter
Size:
48,422 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TUTLB_HUMAN, Q9UPX0 (See protein sequence)
Recommended Name: Protein turtle homolog B precursor  
Size: 1349 amino acids; 147089 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein (Potential)

Explore the universe of human proteins at neXtProt for IGSF9B: NX_Q9UPX0

Explore proteomics data for IGSF9B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UPX0

  • IGSF9B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IGSF9B Protein Expression
    REFSEQ proteins: NP_001264214.1  
    ENSEMBL proteins: 
     ENSP00000436552   ENSP00000434026   ENSP00000435989   ENSP00000317980  

    Human Recombinant Protein Products for IGSF9B: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IGSF9B 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    IGSF9B for ontologies           About GeneDecksing



    IGSF9B Antibody Products: 
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    Cloud-Clone Corp. ELISAs for IGSF9B 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5/7 InterPro protein domains (see all 7):
     IPR003598 Ig_sub2
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q9UPX0

    ProtoNet protein and cluster: Q9UPX0

    UniProtKB/Swiss-Prot: TUTLB_HUMAN, Q9UPX0
    Similarity: Belongs to the immunoglobulin superfamily. Turtle family
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 5 Ig-like (immunoglobulin-like) domains


    IGSF9B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    IGSF9B for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Igsf9b (no phenotypes)

    IGSF9B for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IGSF9B 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGSF9B 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGSF9B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGSF9B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGSF9B (TUTLB)

    Search CenterWatch for drugs/clinical trials and news about IGSF9B / TUTLB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IGSF9B gene (2 alternative transcripts): 
    NM_014987.1  NM_001277285.1  

    Unigene Cluster for IGSF9B:

    Immunoglobulin superfamily, member 9B
    Hs.204121  [show with all ESTs]
    Unigene Representative Sequence: NM_014987
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564347 ENST00000533871(uc001qgy.1) ENST00000530957 ENST00000527648
    ENST00000533160(uc001qgz.2) ENST00000526663 ENST00000321016(uc001qgx.4)

    miRNA
    Products:
         
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate IGSF9B (see all 28):
    hsa-miR-3678-3p hsa-miR-125a-3p hsa-miR-200a hsa-miR-339-5p hsa-miR-515-5p hsa-miR-4314 hsa-miR-141 hsa-miR-1184
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IGSF9B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGSF9B
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGSF9B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGSF9B

    Additional mRNA sequence: 

    AB028953.1 AB231704.1 AK097578.1 AY358228.1 

    4 DOTS entries:

    DT.40245170  DT.120701381  DT.40229924  DT.40229921 

    8 AceView cDNA sequences:

    AY358228 BX951897 AB028953 AA659553 AK097578 AV733321 BF875359 AA324041 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGSF9B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IGSF9B Expression
    About this image


    See IGSF9B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGSF9B

    SOURCE GeneReport for Unigene cluster: Hs.204121
        SABiosciences Custom PCR Arrays for IGSF9B
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for IGSF9B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGSF9B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for IGSF9B gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igsf9b1 , 5 immunoglobulin superfamily, member 9B1, 5 89.42(n)1
    96.16(a)1
      9 (12.69 cM)5
    2350861  NM_001129787.11  NP_001123259.11 
     272992285 
    chicken
    (Gallus gallus)
    Aves IGSF9B1 immunoglobulin superfamily, member 9B 81.55(n)
    85.82(a)
      428237  XM_425796.3  XP_425796.3 
    lizard
    (Anolis carolinensis)
    Reptilia IGSF9B6
    immunoglobulin superfamily, member 9B
    80(a)
    1 ↔ 1
    GL343197.1(3415236-3583977)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5695541 protein turtle homolog B-like 70.04(n)
    72.07(a)
      569554  XM_692949.4  XP_698041.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG168576
    tutl6
    turtle
    26(a)
    19(a)
    many ↔ many
    many ↔ many
    2L(4324573-4331837)
    2L(4283148-4323781)
    worm
    (Caenorhabditis elegans)
    Secernentea igcm-26
    Protein IGCM-2
    24(a)
    1 → many
    X(6379484-6384845)


    ENSEMBL Gene Tree for IGSF9B (if available)
    TreeFam Gene Tree for IGSF9B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGSF9B gene
    IGSF92  
    4 SIMAP similar genes for IGSF9B using alignment to 5 protein entries:     TUTLB_HUMAN (see all proteins):
    IGSF9    MUSK    PTPRD    OPCML

    IGSF9B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1038 SNPs in IGSF9B are shown (see all 1038)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1914529551,2
    --133784296(+) CACCTA/GAGAAA 1 -- int10--------
    rs746214871,2
    F--133784319(+) GCAACA/GTACTT 1 -- int10--------
    rs1438694611,2
    --133784320(+) CAACGC/TACTTG 1 -- int10--------
    rs1171853331,2
    C,F--133784377(+) ACAGAC/TCAGGG 1 -- int11Minor allele frequency- T:0.01NA 120
    rs1175439311,2
    F--133784383(+) CAGGGC/TTGGAG 1 -- int11Minor allele frequency- T:0.01NA 120
    rs730320621,2
    C--133784410(+) TGTATC/AGTCAA 1 -- int15Minor allele frequency- A:0.11NA WA EA 362
    rs9010351,2
    C,F,H--133784499(+) CTTCCG/AGGACA 1 -- int124Minor allele frequency- A:0.14MN NS EA NA WA 2946
    rs116060701,2
    C,F,H--133784630(+) TGGCAG/AAACAG 1 -- int11Minor allele frequency- A:0.33NA 6
    rs762919671,2
    C,F--133784750(+) CAATCG/AAATTG 1 -- int11Minor allele frequency- A:0.06NA 120
    rs1486248151,2
    --133784829(+) GGAGCC/TCTTGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for IGSF9B (133778459 - 133826880 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for IGSF9B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745309CNV Deletion23290073
    esv2745307CNV Deletion23290073
    esv2745310CNV Deletion23290073
    nsv826145CNV Loss20364138
    nsv898472CNV Loss21882294
    nsv826144CNV Gain20364138
    nsv826146CNV Gain20364138
    esv275426CNV Gain+Loss21479260

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IGSF9B for disorders           About MalaCards
    OMIM gene information: 613773    OMIM disorders: --


    IGSF9B for disorders           About GeneDecksing


    Export disorders for IGSF9B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGSF9B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with IGSF9B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
    2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1 Clark H.F.... Gray A.M. (2003)
    6. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22997 HGNC: 32326 AceView: KIAA1030 Ensembl:ENSG00000080854 euGenes: HUgn22997
    ECgene: IGSF9B H-InvDB: IGSF9B

    (According to HUGE)
    About This Section
    HUGE: KIAA1030

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGSF9B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IGSF9B gene:
    Search GeneIP for patents involving IGSF9B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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