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Aliases for IGSF9 Gene

Aliases for IGSF9 Gene

  • Immunoglobulin Superfamily, Member 9 2 3
  • Immunoglobulin Superfamily Member 9A 3 4
  • KIAA1355 4 6
  • IGSF9A 3 4
  • Nrt1 3 4
  • Protein Turtle Homolog A 3
  • FP18798 3

External Ids for IGSF9 Gene

Summaries for IGSF9 Gene

GeneCards Summary for IGSF9 Gene

IGSF9 (Immunoglobulin Superfamily, Member 9) is a Protein Coding gene. An important paralog of this gene is IGSF9B.

UniProtKB/Swiss-Prot for IGSF9 Gene

  • Functions in dendrite outgrowth and synapse maturation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGSF9 Gene

Genomics for IGSF9 Gene

Genomic Location for IGSF9 Gene

Start:
159,927,039 bp from pter
End:
159,945,604 bp from pter
Size:
18,566 bases
Orientation:
Minus strand

Genomic View for IGSF9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGSF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGSF9 Gene

Regulatory Elements for IGSF9 Gene

Proteins for IGSF9 Gene

  • Protein details for IGSF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2J2-TUTLA_HUMAN
    Recommended name:
    Protein turtle homolog A
    Protein Accession:
    Q9P2J2
    Secondary Accessions:

    Protein attributes for IGSF9 Gene

    Size:
    1179 amino acids
    Molecular mass:
    126580 Da
    Quaternary structure:
    • Interacts with MAGI2 and SHANK1.
    SequenceCaution:
    • Sequence=BAA92593.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGSF9 Gene

    Alternative splice isoforms for IGSF9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGSF9 Gene

Proteomics data for IGSF9 Gene at MOPED

Post-translational modifications for IGSF9 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn188, Asn256, Asn513, and Asn524

Other Protein References for IGSF9 Gene

No data available for DME Specific Peptides for IGSF9 Gene

Domains for IGSF9 Gene

Gene Families for IGSF9 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • FN3 :Fibronectin type III domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for IGSF9 Gene

UniProtKB/Swiss-Prot:

TUTLA_HUMAN
Domain:
  • The PDZ-binding motif mediates interactions with MAGI2 and SHANK1.:
    • Q9P2J2
  • Contains 2 fibronectin type-III domains.:
    • Q9P2J2
  • Contains 5 Ig-like (immunoglobulin-like) domains.:
    • Q9P2J2
Family:
  • Belongs to the immunoglobulin superfamily. Turtle family.:
    • Q9P2J2
genes like me logo Genes that share domains with IGSF9: view

Function for IGSF9 Gene

Molecular function for IGSF9 Gene

UniProtKB/Swiss-Prot Function: Functions in dendrite outgrowth and synapse maturation.

Gene Ontology (GO) - Molecular Function for IGSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0098632 protein binding involved in cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with IGSF9: view

Phenotypes for IGSF9 Gene

MGI mutant phenotypes for IGSF9:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with IGSF9: view

Animal Models for IGSF9 Gene

MGI Knock Outs for IGSF9:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IGSF9 Gene

Localization for IGSF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGSF9 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Note=Enriched at the excitatory synapses in mature neurons. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGSF9 Gene COMPARTMENTS Subcellular localization image for IGSF9 gene
Compartment Confidence
plasma membrane 5
chloroplast 1

Gene Ontology (GO) - Cellular Components for IGSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0030424 axon IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with IGSF9: view

Pathways for IGSF9 Gene

SuperPathways for IGSF9 Gene

No Data Available

Interacting Proteins for IGSF9 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357073%0d%0a9606.ENSP00000363827%0d%0a
Selected Interacting proteins: ENSP00000357073 Q9P2J2-TUTLA_HUMAN for IGSF9 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for IGSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0016358 dendrite development IEA --
GO:0050807 regulation of synapse organization IEA --
genes like me logo Genes that share ontologies with IGSF9: view

No data available for Pathways by source for IGSF9 Gene

Transcripts for IGSF9 Gene

Unigene Clusters for IGSF9 Gene

Immunoglobulin superfamily, member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGSF9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b ·
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - -
SP5: -
SP6: -
SP7: -
SP8:

ExUns: 17c ^ 18 ^ 19a · 19b · 19c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -

Relevant External Links for IGSF9 Gene

GeneLoc Exon Structure for
IGSF9
ECgene alternative splicing isoforms for
IGSF9

Expression for IGSF9 Gene

mRNA expression in normal human tissues for IGSF9 Gene

mRNA differential expression in normal tissues according to GTEx for IGSF9 Gene

This gene is overexpressed in Liver (12.7), Skin - Not Sun Exposed (Suprapubic) (5.5), Colon - Transverse (5.0), and Skin - Sun Exposed (Lower leg) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IGSF9 Gene

SOURCE GeneReport for Unigene cluster for IGSF9 Gene Hs.591472

genes like me logo Genes that share expressions with IGSF9: view

Orthologs for IGSF9 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGSF9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGSF9 36
  • 98.84 (n)
  • 98.47 (a)
IGSF9 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGSF9 36
  • 89 (n)
  • 89.99 (a)
IGSF9 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGSF9 36
  • 88.73 (n)
  • 90.14 (a)
IGSF9 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igsf9 36
  • 85.84 (n)
  • 87.79 (a)
Igsf9 16
Igsf9 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGSF9 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGSF9 37
  • 33 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igsf9 36
  • 85.67 (n)
  • 86.85 (a)
chicken
(Gallus gallus)
Aves IGSF9 36
  • 66.57 (n)
  • 61.19 (a)
IGSF9 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGSF9 37
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igsf9 36
  • 61.44 (n)
  • 58.58 (a)
zebrafish
(Danio rerio)
Actinopterygii igsf9a 37
  • 24 (a)
OneToMany
igsf9b 36
  • 54.64 (n)
  • 51.17 (a)
igsf9b 37
  • 24 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG16857 37
  • 25 (a)
ManyToMany
tutl 37
  • 21 (a)
ManyToMany
tutl 38
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea igcm-2 37
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
OneToMany
Species with no ortholog for IGSF9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IGSF9 Gene

ENSEMBL:
Gene Tree for IGSF9 (if available)
TreeFam:
Gene Tree for IGSF9 (if available)

Paralogs for IGSF9 Gene

Paralogs for IGSF9 Gene

Selected SIMAP similar genes for IGSF9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IGSF9: view

Variants for IGSF9 Gene

Sequence variations from dbSNP and Humsavar for IGSF9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1316275 -- 159,943,598(+) CACCC(A/G)AGGAA utr-variant-5-prime
rs1316859 -- 159,936,376(-) GGCTG(C/G)GGTCC intron-variant
rs1319080 - 159,927,769(+) CTCTG(G/T)CTCAG missense, reference
rs1320566 -- 159,933,844(-) GTGCT(A/G)TGTGG intron-variant
rs1320568 -- 159,942,556(-) TACTA(C/T)CTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGSF9 Gene

Variant ID Type Subtype PubMed ID
nsv872489 CNV Loss 21882294
nsv464150 CNV Gain 19166990
nsv524006 CNV Gain 19592680
nsv516637 CNV Loss 19592680

Relevant External Links for IGSF9 Gene

HapMap Linkage Disequilibrium report
IGSF9

Disorders for IGSF9 Gene

No disorders were found for IGSF9 Gene.

No data available for UniProtKB/Swiss-Prot for IGSF9 Gene

Publications for IGSF9 Gene

  1. Cloning and characterization of Igsf9 in mouse and human: a new member of the immunoglobulin superfamily expressed in the developing nervous system. (PMID: 11991715) Doudney K. … Stanier P. (Genomics 2002) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3

Products for IGSF9 Gene

Sources for IGSF9 Gene

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