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Aliases for IGSF9 Gene

Aliases for IGSF9 Gene

  • Immunoglobulin Superfamily Member 9 2 3 5
  • Immunoglobulin Superfamily Member 9A 3 4
  • IGSF9A 3 4
  • Nrt1 3 4
  • Immunoglobulin Superfamily, Member 9 2
  • Protein Turtle Homolog A 3
  • KIAA1355 4
  • FP18798 3

External Ids for IGSF9 Gene

Previous GeneCards Identifiers for IGSF9 Gene

  • GC01M157689
  • GC01M155629
  • GC01M156674
  • GC01M157113
  • GC01M156709
  • GC01M158163
  • GC01M159896
  • GC01M131253

Summaries for IGSF9 Gene

GeneCards Summary for IGSF9 Gene

IGSF9 (Immunoglobulin Superfamily Member 9) is a Protein Coding gene. GO annotations related to this gene include protein binding involved in cell-cell adhesion. An important paralog of this gene is IGSF9B.

UniProtKB/Swiss-Prot for IGSF9 Gene

  • Functions in dendrite outgrowth and synapse maturation.

Additional gene information for IGSF9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGSF9 Gene

Genomics for IGSF9 Gene

Regulatory Elements for IGSF9 Gene

Enhancers for IGSF9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H159888 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +55.1 55121 3 HDGF ATF1 SIN3A ZNF2 GLIS2 ZNF143 ZNF207 FOS ATF7 RUNX3 ENSG00000272668 SLAMF8 SNHG28 FCRL6 VSIG8 ENSG00000212161 IGSF9 DUSP23 PIGM SLAMF9
GH01H159936 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10 +4.1 4147 10 PKNOX1 ATF1 SIN3A ZNF2 ZBTB7B YY1 ETS1 ZNF121 GLIS2 ZNF143 ATP1A4 KCNJ10 IGSF9 NHLH1 LINC01133 VSIG8 CFAP45 VANGL2 TAGLN2
GH01H159803 0.5 ENCODE 10.2 +141.0 140994 1 FOSL1 CEBPB CEBPG SLAMF8 ENSG00000212161 SNHG28 VSIG8 DUSP23 IGSF9 FCRL6 LOC105371464
GH01H160407 1.2 FANTOM5 ENCODE 4.1 -464.0 -464004 4 MXI1 PKNOX1 KLF1 ZNF473 KLF17 ZNF121 ZFHX2 GLIS2 ZNF547 SCRT2 NCSTN LOC729867 LOC148430 COPA VANGL2 IGSF9 LOC105371466 LOC105371467
GH01H159907 0.2 ENCODE 11 +38.5 38459 0 VSIG8 SNHG28 IGSF9 ENSG00000212161 FCRL6 DUSP23 PIGM ENSG00000279430 GC01P159904 PIR60584
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGSF9 on UCSC Golden Path with GeneCards custom track

Promoters for IGSF9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014476 -196 801 PKNOX1 ATF1 SIN3A ZBTB7B YY1 ETS1 GLIS2 ZNF143 ATF7 SP3

Genomic Location for IGSF9 Gene

Chromosome:
1
Start:
159,927,039 bp from pter
End:
159,945,604 bp from pter
Size:
18,566 bases
Orientation:
Minus strand

Genomic View for IGSF9 Gene

Genes around IGSF9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGSF9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGSF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGSF9 Gene

Proteins for IGSF9 Gene

  • Protein details for IGSF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2J2-TUTLA_HUMAN
    Recommended name:
    Protein turtle homolog A
    Protein Accession:
    Q9P2J2

    Protein attributes for IGSF9 Gene

    Size:
    1179 amino acids
    Molecular mass:
    126580 Da
    Quaternary structure:
    • Interacts with MAGI2 and SHANK1.
    SequenceCaution:
    • Sequence=BAA92593.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGSF9 Gene

    Alternative splice isoforms for IGSF9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGSF9 Gene

Post-translational modifications for IGSF9 Gene

  • Glycosylation at posLast=188188, isoforms=2256, isoforms=2513, and isoforms=2524
  • Modification sites at PhosphoSitePlus

Other Protein References for IGSF9 Gene

No data available for DME Specific Peptides for IGSF9 Gene

Domains & Families for IGSF9 Gene

Gene Families for IGSF9 Gene

Protein Domains for IGSF9 Gene

Suggested Antigen Peptide Sequences for IGSF9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2J2

UniProtKB/Swiss-Prot:

TUTLA_HUMAN :
  • The PDZ-binding motif mediates interactions with MAGI2 and SHANK1.
  • Belongs to the immunoglobulin superfamily. Turtle family.
Domain:
  • The PDZ-binding motif mediates interactions with MAGI2 and SHANK1.
Family:
  • Belongs to the immunoglobulin superfamily. Turtle family.
genes like me logo Genes that share domains with IGSF9: view

Function for IGSF9 Gene

Molecular function for IGSF9 Gene

UniProtKB/Swiss-Prot Function:
Functions in dendrite outgrowth and synapse maturation.

Gene Ontology (GO) - Molecular Function for IGSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098632 protein binding involved in cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with IGSF9: view
genes like me logo Genes that share phenotypes with IGSF9: view

Animal Models for IGSF9 Gene

MGI Knock Outs for IGSF9:

Animal Model Products

  • Taconic Biosciences Mouse Models for IGSF9

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IGSF9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGSF9 Gene

Localization for IGSF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGSF9 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Note=Enriched at the excitatory synapses in mature neurons. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGSF9 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for IGSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with IGSF9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IGSF9 Gene

Pathways & Interactions for IGSF9 Gene

SuperPathways for IGSF9 Gene

No Data Available

Interacting Proteins for IGSF9 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357073%0d%0a9606.ENSP00000368190%0d%0a9606.ENSP00000261349%0d%0a9606.ENSP00000294304%0d%0a9606.ENSP00000355208%0d%0a9606.ENSP00000372437%0d%0a
Selected Interacting proteins: ENSP00000357073 Q9P2J2-TUTLA_HUMAN for IGSF9 Gene via STRING IID

Gene Ontology (GO) - Biological Process for IGSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0016358 dendrite development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with IGSF9: view

No data available for Pathways by source and SIGNOR curated interactions for IGSF9 Gene

Drugs & Compounds for IGSF9 Gene

No Compound Related Data Available

Transcripts for IGSF9 Gene

Unigene Clusters for IGSF9 Gene

Immunoglobulin superfamily, member 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IGSF9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IGSF9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b ·
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - -
SP5: -
SP6: -
SP7: -
SP8:

ExUns: 17c ^ 18 ^ 19a · 19b · 19c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -

Relevant External Links for IGSF9 Gene

GeneLoc Exon Structure for
IGSF9
ECgene alternative splicing isoforms for
IGSF9

Expression for IGSF9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGSF9 Gene

mRNA differential expression in normal tissues according to GTEx for IGSF9 Gene

This gene is overexpressed in Liver (x12.7), Skin - Not Sun Exposed (Suprapubic) (x5.5), Colon - Transverse (x5.0), and Skin - Sun Exposed (Lower leg) (x4.4).

Protein differential expression in normal tissues from HIPED for IGSF9 Gene

This gene is overexpressed in Breast (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IGSF9 Gene



Protein tissue co-expression partners for IGSF9 Gene

NURSA nuclear receptor signaling pathways regulating expression of IGSF9 Gene:

IGSF9

SOURCE GeneReport for Unigene cluster for IGSF9 Gene:

Hs.591472

Evidence on tissue expression from TISSUES for IGSF9 Gene

  • Liver(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with IGSF9: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGSF9 Gene

Orthologs for IGSF9 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGSF9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGSF9 33 34
  • 98.84 (n)
cow
(Bos Taurus)
Mammalia IGSF9 33 34
  • 89 (n)
dog
(Canis familiaris)
Mammalia IGSF9 33 34
  • 88.73 (n)
mouse
(Mus musculus)
Mammalia Igsf9 33 16 34
  • 85.84 (n)
rat
(Rattus norvegicus)
Mammalia Igsf9 33
  • 85.67 (n)
oppossum
(Monodelphis domestica)
Mammalia IGSF9 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGSF9 34
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGSF9 33 34
  • 66.57 (n)
lizard
(Anolis carolinensis)
Reptilia IGSF9 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igsf9 33
  • 61.44 (n)
zebrafish
(Danio rerio)
Actinopterygii igsf9b 33 34
  • 54.64 (n)
igsf9a 34
  • 24 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta tutl 35 34
  • 30 (a)
CG16857 34
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea igcm-2 34
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToMany
Species where no ortholog for IGSF9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IGSF9 Gene

ENSEMBL:
Gene Tree for IGSF9 (if available)
TreeFam:
Gene Tree for IGSF9 (if available)

Paralogs for IGSF9 Gene

Paralogs for IGSF9 Gene

(1) SIMAP similar genes for IGSF9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IGSF9: view

Variants for IGSF9 Gene

Sequence variations from dbSNP and Humsavar for IGSF9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000208933 -- 159,947,588(+) AATCA(C/T)TGGGA upstream-variant-2KB
rs1000215251 -- 159,944,970(+) ACTAG(A/G)CATCC intron-variant
rs1000247109 -- 159,938,312(+) GACCC(A/C/G)GCCTG intron-variant
rs1000583083 -- 159,939,887(+) CATAC(C/T)CTTCC intron-variant
rs1000658078 -- 159,940,184(+) GACGC(G/T)GCGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGSF9 Gene

Variant ID Type Subtype PubMed ID
nsv1005195 CNV gain 25217958
nsv464150 CNV gain 19166990
nsv516637 CNV loss 19592680
nsv524006 CNV gain 19592680
nsv548052 CNV gain 21841781
nsv548053 CNV loss 21841781
nsv548054 CNV loss 21841781

Variation tolerance for IGSF9 Gene

Residual Variation Intolerance Score: 10.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.07; 84.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGSF9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGSF9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGSF9 Gene

Disorders for IGSF9 Gene

Relevant External Links for IGSF9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGSF9

No disorders were found for IGSF9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGSF9 Gene

Publications for IGSF9 Gene

  1. Cloning and characterization of Igsf9 in mouse and human: a new member of the immunoglobulin superfamily expressed in the developing nervous system. (PMID: 11991715) Doudney K … Stanier P (Genomics 2002) 2 3 4 60
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 60
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U … Wanker EE (Cell 2005) 3 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 60

Products for IGSF9 Gene

Sources for IGSF9 Gene

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