Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IGSF8 Gene

Aliases for IGSF8 Gene

  • Immunoglobulin Superfamily, Member 8 2 3
  • CD81P3 3 4 6
  • PGRL 3 4 6
  • Keratinocytes-Associated Transmembrane Protein 4 3 4
  • Glu-Trp-Ile EWI Motif-Containing Protein 2 3 4
  • Prostaglandin Regulatory-Like Protein 3 4
  • CD81 Partner 3 3 4
  • LIR-D1 3 4
  • EWI-2 3 4
  • KCT-4 3 4
  • EWI2 3 4
  • Immunoglobulin Superfamily Member 8 3
  • CD316 Antigen 4
  • CD316 3
  • IgSF8 4
  • KCT4 4

External Ids for IGSF8 Gene

Previous GeneCards Identifiers for IGSF8 Gene

  • GC01M157853
  • GC01M155793
  • GC01M156839
  • GC01M157277
  • GC01M156874
  • GC01M158327
  • GC01M131418

Summaries for IGSF8 Gene

Entrez Gene Summary for IGSF8 Gene

  • This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

GeneCards Summary for IGSF8 Gene

IGSF8 (Immunoglobulin Superfamily, Member 8) is a Protein Coding gene. An important paralog of this gene is PTGFRN.

UniProtKB/Swiss-Prot for IGSF8 Gene

  • May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.

Gene Wiki entry for IGSF8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGSF8 Gene

Genomics for IGSF8 Gene

Regulatory Elements for IGSF8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IGSF8 Gene

Start:
160,091,339 bp from pter
End:
160,098,943 bp from pter
Size:
7,605 bases
Orientation:
Minus strand

Genomic View for IGSF8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGSF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGSF8 Gene

Proteins for IGSF8 Gene

  • Protein details for IGSF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969P0-IGSF8_HUMAN
    Recommended name:
    Immunoglobulin superfamily member 8
    Protein Accession:
    Q969P0
    Secondary Accessions:
    • Q8NG09
    • Q96DP4
    • Q9BTG9

    Protein attributes for IGSF8 Gene

    Size:
    613 amino acids
    Molecular mass:
    65034 Da
    Quaternary structure:
    • Interacts directly with CD82, CD81/tetraspanin-28 and CD9/tetraspanin-29. Also interacts with integrin alpha-3/beta-1 and integrin alpha-4/beta-1.

    Alternative splice isoforms for IGSF8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGSF8 Gene

Proteomics data for IGSF8 Gene at MOPED

Post-translational modifications for IGSF8 Gene

  • Ubiquitination at Lys143
  • Glycosylation at Asn50, Asn327, and Asn463
  • Modification sites at PhosphoSitePlus

Other Protein References for IGSF8 Gene

Antibody Products

No data available for DME Specific Peptides for IGSF8 Gene

Domains for IGSF8 Gene

Gene Families for IGSF8 Gene

HGNC:
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for IGSF8 Gene

Suggested Antigen Peptide Sequences for IGSF8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969P0

UniProtKB/Swiss-Prot:

IGSF8_HUMAN :
  • Q969P0
Domain:
  • The Ig-like C2-type domains 3 and 4 are required for interaction with CD81.
  • The short cytoplasmic domain is very basic, interacts with membrane PIPs, and mediates plasma membrane localization.
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with IGSF8: view

Function for IGSF8 Gene

Molecular function for IGSF8 Gene

UniProtKB/Swiss-Prot Function:
May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.

Gene Ontology (GO) - Molecular Function for IGSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11504738
genes like me logo Genes that share ontologies with IGSF8: view

Animal Model Products

miRNA for IGSF8 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IGSF8 Gene

Localization for IGSF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGSF8 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGSF8 Gene COMPARTMENTS Subcellular localization image for IGSF8 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for IGSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IDA 11504738
GO:0030424 axon IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with IGSF8: view

Pathways for IGSF8 Gene

SuperPathways for IGSF8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component NAS 11504738
GO:0007338 single fertilization NAS 11504738
GO:0007399 nervous system development NAS 11504738
GO:0007519 skeletal muscle tissue development NAS 11504738
GO:0008283 cell proliferation NAS 11504738
genes like me logo Genes that share ontologies with IGSF8: view

No data available for Pathways by source for IGSF8 Gene

Transcripts for IGSF8 Gene

Unigene Clusters for IGSF8 Gene

Immunoglobulin superfamily, member 8:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGSF8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGSF8 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for IGSF8 Gene

GeneLoc Exon Structure for
IGSF8
ECgene alternative splicing isoforms for
IGSF8

Expression for IGSF8 Gene

mRNA expression in normal human tissues for IGSF8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for IGSF8 Gene

This gene is overexpressed in Frontal cortex (34.0) and Brain (12.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IGSF8 Gene

SOURCE GeneReport for Unigene cluster for IGSF8 Gene Hs.332012

mRNA Expression by UniProt/SwissProt for IGSF8 Gene

Q969P0-IGSF8_HUMAN
Tissue specificity: Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets.
genes like me logo Genes that share expressions with IGSF8: view

Expression partners for IGSF8 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for IGSF8 Gene

Orthologs for IGSF8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGSF8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IGSF8 35
  • 88.06 (n)
  • 92.23 (a)
IGSF8 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGSF8 35
  • 86.48 (n)
  • 93.53 (a)
IGSF8 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igsf8 35
  • 85.7 (n)
  • 89.86 (a)
Igsf8 16
Igsf8 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IGSF8 35
  • 99.38 (n)
  • 99.32 (a)
IGSF8 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igsf8 35
  • 85.42 (n)
  • 90.03 (a)
oppossum
(Monodelphis domestica)
Mammalia IGSF8 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGSF8 36
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii igsf8 35
  • 48.15 (n)
  • 41.12 (a)
igsf8 36
  • 36 (a)
OneToOne
Species with no ortholog for IGSF8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGSF8 Gene

ENSEMBL:
Gene Tree for IGSF8 (if available)
TreeFam:
Gene Tree for IGSF8 (if available)

Paralogs for IGSF8 Gene

Paralogs for IGSF8 Gene

Selected SIMAP similar genes for IGSF8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IGSF8: view

Variants for IGSF8 Gene

Sequence variations from dbSNP and Humsavar for IGSF8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1131891 -- 160,091,594(-) GTGTC(A/C/G)ACTGT utr-variant-3-prime
rs2145387 -- 160,091,081(-) TAGGT(C/T)CCAGC downstream-variant-500B
rs2295620 -- 160,094,090(-) CATGA(C/T)GGTGC reference, missense
rs2295621 -- 160,092,937(-) GTACA(C/T)GTGCG synonymous-codon, reference
rs2295622 -- 160,092,682(-) CTGGA(A/C/G)GCTGT synonymous-codon, missense, reference

Structural Variations from Database of Genomic Variants (DGV) for IGSF8 Gene

Variant ID Type Subtype PubMed ID
nsv520189 CNV Loss 19592680

Relevant External Links for IGSF8 Gene

HapMap Linkage Disequilibrium report
IGSF8
Human Gene Mutation Database (HGMD)
IGSF8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGSF8 Gene

Disorders for IGSF8 Gene

No disorders were found for IGSF8 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for IGSF8 Gene

Publications for IGSF8 Gene

  1. EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. (PMID: 12750295) Zhang X.A. … Liu L. (Cancer Res. 2003) 3 4 23
  2. EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5. (PMID: 14662754) Stipp C.S. … Hemler M.E. (J. Cell Biol. 2003) 3 4 23
  3. EWI-2 modulates lymphocyte integrin alpha4beta1 functions. (PMID: 15070678) Kolesnikova T.V. … Hemler M.E. (Blood 2004) 3 4 23
  4. EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. (PMID: 11504738) Stipp C.S. … Hemler M.E. (J. Biol. Chem. 2001) 2 3 4
  5. PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins. (PMID: 11673522) Clark K.L. … Todd S.C. (J. Immunol. 2001) 2 3

Products for IGSF8 Gene

Sources for IGSF8 Gene

Back to Top

Content