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IGSF8 Gene

protein-coding   GIFtS: 55
GCID: GC01M160061

Immunoglobulin Superfamily, Member 8

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immunoglobulin Superfamily, Member 81 2     KCT-42 3
CD81P32 3 5     LIR-D12 3
PGRL2 3 5     CD81 Partner 32 3
Glu-Trp-Ile EWI Motif-Containing Protein 22 3     CD3162
Keratinocytes-Associated Transmembrane Protein 42 3     Immunoglobulin Superfamily Member 82
Prostaglandin Regulatory-Like Protein2 3     IgSF83
EWI-22 3     KCT43
EWI22 3     CD316 Antigen3

External Ids:    HGNC: 178131   Entrez Gene: 931852   Ensembl: ENSG000001627297   OMIM: 6066445   UniProtKB: Q969P03   

Export aliases for IGSF8 gene to outside databases

Previous GC identifers: GC01M157853 GC01M155793 GC01M156839 GC01M157277 GC01M156874 GC01M158327 GC01M131418


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IGSF8 Gene:
This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family
contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin
domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain
cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor
suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript
variants that encode the same protein. (provided by RefSeq, Sep 2011)

GeneCards Summary for IGSF8 Gene:
IGSF8 (immunoglobulin superfamily, member 8) is a protein-coding gene. An important paralog of this gene is IGSF3.

UniProtKB/Swiss-Prot: IGSF8_HUMAN, Q969P0
Function: May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or
hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative
regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress
prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and
CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May
participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain

Gene Wiki entry for IGSF8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IGSF8 gene promoter:
         GR   E2F-4   E2F-3a   E2F-5   HTF   E2F-2   HEN1   E2F   E2F-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGSF8 promoter sequence
   Search Chromatin IP Primers for IGSF8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGSF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q23.1

IGSF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGSF8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M160061:  view genomic region     (about GC identifiers)

Start:
160,061,130 bp from pter      End:
160,068,733 bp from pter
Size:
7,604 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IGSF8_HUMAN, Q969P0 (See protein sequence)
Recommended Name: Immunoglobulin superfamily member 8 precursor  
Size: 613 amino acids; 65034 Da
Subunit: Interacts directly with CD82, CD81/tetraspanin-28 and CD9/tetraspanin-29. Also interacts with integrin
alpha-3/beta-1 and integrin alpha-4/beta-1
Secondary accessions: Q8NG09 Q96DP4 Q9BTG9
Alternative splicing: 3 isoforms:  Q969P0-1   Q969P0-2   Q969P0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IGSF8: NX_Q969P0

Explore proteomics data for IGSF8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys143
  • Glycosylation2 at Asn50, Asn327, Asn463
  • Modification sites at PhosphoSitePlus

  • See IGSF8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001193594.1  NP_443100.1  

    ENSEMBL proteins: 
     ENSP00000316664   ENSP00000357065   ENSP00000397464  

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    antibodies-online proteins for IGSF8 (8 products) 

     
    antibodies-online peptides for IGSF8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q969P0

    ProtoNet protein and cluster: Q969P0

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: IGSF8_HUMAN, Q969P0
    Domain: The Ig-like C2-type domains 3 and 4 are required for interaction with CD81 (By similarity)
    Domain: The short cytoplasmic domain is very basic, interacts with membrane PIPs, and mediates plasma membrane
    localization (By similarity)
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with IGSF8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IGSF8_HUMAN, Q969P0
    Function: May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or
    hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative
    regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress
    prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and
    CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May
    participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11504738
         
    Find genes that share ontologies with IGSF8           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IGSF8

    miRNA
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    miRTarBase miRNAs that target IGSF8:
    hsa-mir-7-5p (MIRT025764), hsa-let-7b-5p (MIRT051892), hsa-mir-92b-3p (MIRT040653), hsa-mir-744-5p (MIRT037601)

    Block miRNA regulation of human, mouse, rat IGSF8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IGSF8 (see all 9):
    hsa-miR-3671 hsa-miR-548am hsa-miR-130a* hsa-miR-23c hsa-miR-7 hsa-miR-23b hsa-miR-2276 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidIGSF8 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IGSF8_HUMAN, Q969P0: Cell membrane (By similarity); Single-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IDA11504738
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with IGSF8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGSF8
    Interactions:

        GeneGlobe Interaction Network for IGSF8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for IGSF8 (Q969P02, 3 ENSP000003166644) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD81P600332, 3, ENSP000002636454MINT-8407185 I2D: score=2 STRING: ENSP00000263645
    CD9P219262, 3, ENSP000000091804MINT-8407185 I2D: score=2 STRING: ENSP00000009180
    CD82P277013, ENSP000002271554I2D: score=2 STRING: ENSP00000227155
    ITGB1P055562, ENSP000003640944MINT-8407185 STRING: ENSP00000364094
    ADAM10O146722MINT-8407185
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement NAS11504738
    GO:0007338single fertilization NAS11504738
    GO:0007399nervous system development NAS11504738
    GO:0007519skeletal muscle tissue development NAS11504738
    GO:0008283cell proliferation NAS11504738

    Find genes that share ontologies with IGSF8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGSF8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IGSF8 gene (2 alternative transcripts): 
    NM_001206665.2  NM_052868.4  

    Unigene Cluster for IGSF8:

    Immunoglobulin superfamily, member 8
    Hs.332012  [show with all ESTs]
    Unigene Representative Sequence: BC053881
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314485(uc001fuz.3 uc009wtf.3) ENST00000368086(uc001fva.3)
    ENST00000448417 ENST00000460351
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    hsa-miR-3671 hsa-miR-548am hsa-miR-130a* hsa-miR-23c hsa-miR-7 hsa-miR-23b hsa-miR-2276 hsa-miR-548x
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    Additional mRNA sequence: 

    AF311906.1 AF407274.1 AK308115.1 AY044845.1 AY157579.1 BC004108.2 BC011896.2 BC023649.2 
    BC053881.1 

    11 DOTS entries:

    DT.313962  DT.97847501  DT.92437526  DT.100794619  DT.100794622  DT.100794615  DT.97791027  DT.100794620 
    DT.100794621  DT.100844795  DT.92437527 

    Selected AceView cDNA sequences (see all 228):

    AI804924 AW025903 T12055 AK090396 AI700165 BQ638965 AI871915 BQ676677 
    AA285001 BC011896 AI810203 BC004108 BI791943 BE302640 BF438614 AA972364 
    BF725746 BG743319 AI863123 BU838314 AI630922 BQ677995 AI619947 AI085288 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for IGSF8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:                                                                    -         
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for IGSF8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGSF8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAGGCTTC
    IGSF8 Expression
    About this image


    IGSF8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)
             Mesencephalic Ventricular Zone
     
     Brain (Nervous System)
             Cerebral Cortex
    IGSF8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGSF8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.332012

    UniProtKB/Swiss-Prot: IGSF8_HUMAN, Q969P0
    Tissue specificity: Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other
    tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear
    cells and platelets

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IGSF8 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igsf81 , 5 immunoglobulin superfamily, member 81, 5 85.7(n)1
    89.86(a)1
      1 (79.59 cM)5
    1405591  NM_080419.11  NP_536344.11 
     1722616415 
    lizard
    (Anolis carolinensis)
    Reptilia IGSF86
    immunoglobulin superfamily, member 8
    51(a)
    1 ↔ 1
    GL344012.1(24819-47881)
    zebrafish
    (Danio rerio)
    Actinopterygii igsf81 immunoglobulin superfamily, member 8 48.15(n)
    41.12(a)
      404631  NM_207099.1  NP_996982.1 


    ENSEMBL Gene Tree for IGSF8 (if available)
    TreeFam Gene Tree for IGSF8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGSF8 gene
    IGSF32  CD1012  PTGFRN2  
    3 SIMAP similar genes for IGSF8 using alignment to 2 protein entries:     IGSF8_HUMAN (see all proteins):
    FLJ00271    CD101    IGSF3

    Find genes that share paralogs with IGSF8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IGSF8 (see all 260)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1479133181,2
    --131417849(+) GGTCCA/CAGACT 2 -- ds50010--------
    rs1128667681,2
    C--131417903(+) CTGGGG/AAGCTC 2 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1808468011,2
    --131418048(+) CTCAGC/TCCCGA 2 -- ds50010--------
    rs1465923511,2
    C--131418258(+) ATAAA-/ACAAGTT 2 -- ut310--------
    rs1856352071,2
    --131418446(+) AGAGGC/GAGAGG 2 -- ut310--------
    rs120587931,2
    C,H--131418475(+) GAGGGC/TTTGGA 2 -- ut31 ese35Minor allele frequency- T:0.00NS EA NA 512
    rs11318911,2
    C,F,H--131418499(-) GTGTCA/C/GACTGT 4 -- ut3118MN NS EA NA CSA 2117
    rs127275201,2
    C--131418529(+) TGCCCG/AGTGTG 2 -- int1 ese33Minor allele frequency- A:0.14NA 124
    rs1415372051,2
    C--131418632(+) GTGGGG/TCCTGG 2 -- int10--------
    rs1899520871,2
    --131418642(+) GGAGGA/GAGCAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for IGSF8 (160061130 - 160068733 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IGSF8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv520189CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IGSF8
    DNA2.0 Custom Variant and Variant Library Synthesis for IGSF8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606644    OMIM disorders: --


    Find genes that share disorders with IGSF8           About GenesLikeMe


    Export disorders for IGSF8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGSF8 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with IGSF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. (PubMed id 11504738)1, 2, 3 Stipp C.S.... Hemler M.E. (J. Biol. Chem. 2001)
    2. EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5. (PubMed id 14662754)1, 2, 9 Stipp C.S.... Hemler M.E. (J. Cell Biol. 2003)
    3. EWI-2 modulates lymphocyte integrin alpha4beta1 functions. (PubMed id 15070678)1, 2, 9 Kolesnikova T.V....Hemler M.E. (Blood 2004)
    4. EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. (PubMed id 12750295)1, 2, 9 Zhang X.A.... Liu L. (Cancer Res. 2003)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes. (PubMed id 12752121)1, 2 Bonkobara M.... Ariizumi K. (Br. J. Dermatol. 2003)
    8. EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells. (PubMed id 12708969)1, 2 Charrin S.... Rubinstein E. (Biochem. J. 2003)
    9. PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins. (PubMed id 11673522)1, 3 Clark K.L....Todd S.C. (J. Immunol. 2001)
    10. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 93185 HGNC: 17813 AceView: IGSF8 Ensembl:ENSG00000162729 euGenes: HUgn93185
    ECgene: IGSF8 H-InvDB: IGSF8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IGSF8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IGSF8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGSF8 gene:
    Search GeneIP for patents involving IGSF8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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