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Aliases for IGSF8 Gene

Aliases for IGSF8 Gene

  • Immunoglobulin Superfamily Member 8 2 3 5
  • Keratinocytes-Associated Transmembrane Protein 4 3 4
  • Glu-Trp-Ile EWI Motif-Containing Protein 2 3 4
  • Prostaglandin Regulatory-Like Protein 3 4
  • CD81 Partner 3 3 4
  • CD81P3 3 4
  • LIR-D1 3 4
  • EWI-2 3 4
  • KCT-4 3 4
  • EWI2 3 4
  • PGRL 3 4
  • Immunoglobulin Superfamily, Member 8 2
  • CD316 Antigen 4
  • CD316 3
  • IgSF8 4
  • KCT4 4

External Ids for IGSF8 Gene

Previous GeneCards Identifiers for IGSF8 Gene

  • GC01M157853
  • GC01M155793
  • GC01M156839
  • GC01M157277
  • GC01M156874
  • GC01M158327
  • GC01M131418

Summaries for IGSF8 Gene

Entrez Gene Summary for IGSF8 Gene

  • This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

GeneCards Summary for IGSF8 Gene

IGSF8 (Immunoglobulin Superfamily Member 8) is a Protein Coding gene. Diseases associated with IGSF8 include Hepatitis C Virus. An important paralog of this gene is CD101.

UniProtKB/Swiss-Prot for IGSF8 Gene

  • May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.

Gene Wiki entry for IGSF8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGSF8 Gene

Genomics for IGSF8 Gene

Regulatory Elements for IGSF8 Gene

Enhancers for IGSF8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G160123 1.5 Ensembl ENCODE dbSUPER 15.9 -27.5 -27479 6.8 HDGF PKNOX1 FOXA2 ATF1 YY1 GLIS2 KLF7 FOS DEK ZNF263 ATP1A4 IGSF8 PEA15 CASQ1 KCNJ9 PIGM ATP1A2 GC01M160128 GC01P160126 GC01P160125
GH01G160095 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -0.6 -605 8.2 HDGF PKNOX1 MLX ARNT WRNIP1 SIN3A ARID4B DMAP1 ZNF2 YY1 ATP1A4 IGSF8 CASQ1 KCNJ10 PEA15 DCAF8 PEX19 PIGM ENSG00000225279 ATP1A2
GH01G160046 1.6 Ensembl ENCODE dbSUPER 10.4 +52.1 52138 1.2 PKNOX1 CREB3L1 ARNT SIN3A ZNF766 CBX5 ZNF143 KLF13 SP5 REST KCNJ9 IGSF8 ENSG00000260766 PIGM ENSG00000225279
GH01G160291 1.4 ENCODE dbSUPER 10.5 -193.1 -193091 1.7 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC NCSTN ENSG00000228606 CASQ1 COPA IGSF8 KCNJ9 RNU4-42P NHLH1 SUMO1P3
GH01G160203 1.3 ENCODE dbSUPER 10.5 -108.8 -108831 7.6 HDGF ATF1 AGO1 ZNF133 ARID4B SIN3A FEZF1 DMAP1 GLI4 ZNF2 NCSTN ENSG00000228606 DCAF8 IGSF8 PIGM COPA LOC729867 PEA15
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGSF8 on UCSC Golden Path with GeneCards custom track

Promoters for IGSF8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014500 243 1401 HDGF ATF1 DEAF1 GLIS2 ZNF143 RELB CREM EGR2 SP3 SP5

Genomic Location for IGSF8 Gene

Chromosome:
1
Start:
160,091,339 bp from pter
End:
160,098,943 bp from pter
Size:
7,605 bases
Orientation:
Minus strand

Genomic View for IGSF8 Gene

Genes around IGSF8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGSF8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGSF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGSF8 Gene

Proteins for IGSF8 Gene

  • Protein details for IGSF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969P0-IGSF8_HUMAN
    Recommended name:
    Immunoglobulin superfamily member 8
    Protein Accession:
    Q969P0
    Secondary Accessions:
    • Q8NG09
    • Q96DP4
    • Q9BTG9

    Protein attributes for IGSF8 Gene

    Size:
    613 amino acids
    Molecular mass:
    65034 Da
    Quaternary structure:
    • Interacts directly with CD82, CD81/tetraspanin-28 and CD9/tetraspanin-29. Also interacts with integrin alpha-3/beta-1 and integrin alpha-4/beta-1.

    Alternative splice isoforms for IGSF8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGSF8 Gene

Post-translational modifications for IGSF8 Gene

  • Ubiquitination at isoforms=3143
  • Glycosylation at isoforms=350, posLast=327327, and isoforms=2, 3463
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IGSF8 Gene

Domains & Families for IGSF8 Gene

Gene Families for IGSF8 Gene

Protein Domains for IGSF8 Gene

Suggested Antigen Peptide Sequences for IGSF8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969P0

UniProtKB/Swiss-Prot:

IGSF8_HUMAN :
  • The Ig-like C2-type domains 3 and 4 are required for interaction with CD81.
Domain:
  • The Ig-like C2-type domains 3 and 4 are required for interaction with CD81.
  • The short cytoplasmic domain is very basic, interacts with membrane PIPs, and mediates plasma membrane localization.
genes like me logo Genes that share domains with IGSF8: view

Function for IGSF8 Gene

Molecular function for IGSF8 Gene

UniProtKB/Swiss-Prot Function:
May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.

Gene Ontology (GO) - Molecular Function for IGSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11504738
genes like me logo Genes that share ontologies with IGSF8: view
genes like me logo Genes that share phenotypes with IGSF8: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IGSF8

CRISPR Products

miRNA for IGSF8 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGSF8 Gene

Localization for IGSF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGSF8 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGSF8 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for IGSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IBA --
GO:0016020 membrane IDA,IEA 19946888
GO:0016021 integral component of membrane IEA,IDA 11504738
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with IGSF8: view

Pathways & Interactions for IGSF8 Gene

SuperPathways for IGSF8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component NAS 11504738
GO:0007338 single fertilization NAS 11504738
GO:0007399 nervous system development NAS 11504738
GO:0007519 skeletal muscle tissue development NAS 11504738
GO:0008283 cell proliferation NAS 11504738
genes like me logo Genes that share ontologies with IGSF8: view

No data available for Pathways by source and SIGNOR curated interactions for IGSF8 Gene

Transcripts for IGSF8 Gene

Unigene Clusters for IGSF8 Gene

Immunoglobulin superfamily, member 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGSF8 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for IGSF8 Gene

GeneLoc Exon Structure for
IGSF8
ECgene alternative splicing isoforms for
IGSF8

Expression for IGSF8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGSF8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IGSF8 Gene

This gene is overexpressed in Frontal cortex (34.0) and Brain (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IGSF8 Gene



Protein tissue co-expression partners for IGSF8 Gene

NURSA nuclear receptor signaling pathways regulating expression of IGSF8 Gene:

IGSF8

SOURCE GeneReport for Unigene cluster for IGSF8 Gene:

Hs.332012

mRNA Expression by UniProt/SwissProt for IGSF8 Gene:

Q969P0-IGSF8_HUMAN
Tissue specificity: Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets.

Evidence on tissue expression from TISSUES for IGSF8 Gene

  • Kidney(4.2)
  • Liver(4.2)
  • Nervous system(4.1)
  • Skin(3.4)
genes like me logo Genes that share expression patterns with IGSF8: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGSF8 Gene

Orthologs for IGSF8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGSF8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGSF8 34 35
  • 99.38 (n)
cow
(Bos Taurus)
Mammalia IGSF8 34 35
  • 88.06 (n)
dog
(Canis familiaris)
Mammalia IGSF8 34 35
  • 86.48 (n)
mouse
(Mus musculus)
Mammalia Igsf8 34 16 35
  • 85.7 (n)
rat
(Rattus norvegicus)
Mammalia Igsf8 34
  • 85.42 (n)
oppossum
(Monodelphis domestica)
Mammalia IGSF8 35
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGSF8 35
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii igsf8 34 35
  • 48.15 (n)
Species where no ortholog for IGSF8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGSF8 Gene

ENSEMBL:
Gene Tree for IGSF8 (if available)
TreeFam:
Gene Tree for IGSF8 (if available)

Paralogs for IGSF8 Gene

Paralogs for IGSF8 Gene

(3) SIMAP similar genes for IGSF8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IGSF8: view

Variants for IGSF8 Gene

Sequence variations from dbSNP and Humsavar for IGSF8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000792721 -- 160,101,260(+) GTCAC(-/ACACACAG)ACACA upstream-variant-2KB
rs1000863795 -- 160,095,448(+) GGGCC(C/T)AGGAT intron-variant, utr-variant-5-prime
rs1000947679 -- 160,099,510(+) GTTGG(A/G)TGATC upstream-variant-2KB
rs1001086451 -- 160,093,747(+) GCCCT(C/T)TTCTC reference, synonymous-codon
rs1001623096 -- 160,095,825(+) GCTGC(A/G)CCATG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for IGSF8 Gene

Variant ID Type Subtype PubMed ID
dgv210n106 CNV deletion 24896259
nsv1079008 CNV deletion 25765185
nsv520189 CNV loss 19592680
nsv952222 CNV deletion 24416366

Variation tolerance for IGSF8 Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGSF8 Gene

Human Gene Mutation Database (HGMD)
IGSF8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGSF8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGSF8 Gene

Disorders for IGSF8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGSF8 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitic c virus
- elite association - COSMIC cancer census association via MalaCards
Search IGSF8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IGSF8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGSF8
genes like me logo Genes that share disorders with IGSF8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGSF8 Gene

Publications for IGSF8 Gene

  1. EWI-2 modulates lymphocyte integrin alpha4beta1 functions. (PMID: 15070678) Kolesnikova T.V. … Hemler M.E. (Blood 2004) 3 4 22 64
  2. EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. (PMID: 12750295) Zhang X.A. … Liu L. (Cancer Res. 2003) 3 4 22 64
  3. EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5. (PMID: 14662754) Stipp C.S. … Hemler M.E. (J. Cell Biol. 2003) 3 4 22 64
  4. EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. (PMID: 11504738) Stipp C.S. … Hemler M.E. (J. Biol. Chem. 2001) 2 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for IGSF8 Gene

Sources for IGSF8 Gene

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