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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IGSF8 Gene

protein-coding   GIFtS: 50
GCID: GC01M160061

immunoglobulin superfamily, member 8
 Explore 5 diseases affiliated with
IGSF8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IGSF8    

Aliases
for IGSF8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Immunoglobulin Superfamily, Member 81 2     EWI-22 3
CD81P31 2 3 5     KCT-42 3
PGRL1 2 3 5     LIR-D12 3
EWI21 2 3     CD81 Partner 32 3
CD3161 2     Immunoglobulin Superfamily Member 82
Glu-Trp-Ile EWI Motif-Containing Protein 22 3     IgSF83
Keratinocytes-Associated Transmembrane Protein 42 3     KCT43
Prostaglandin Regulatory-Like Protein2 3     CD316 Antigen3

External Ids:    HGNC: 178131   Entrez Gene: 931852   Ensembl: ENSG000001627297   OMIM: 6066445   UniProtKB: Q969P03   

Export aliases for IGSF8 gene to outside databases

Previous GC identifers: GC01M157853 GC01M155793 GC01M156839 GC01M157277 GC01M156874 GC01M158327 GC01M131418


Summaries
for IGSF8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IGSF8:
This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain
a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This
protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions
including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by
inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that
encode the same protein. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: IGSF8_HUMAN, Q969P0
Function: May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis
C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell
motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell
migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May
also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite
outgrowth and maintenance of the neural network in the adult brain

Gene Wiki entry for IGSF8


Genomic Views
for IGSF8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IGSF8 gene promoter:
         GR   E2F-4   E2F-3a   E2F-5   HTF   E2F-2   HEN1   E2F   E2F-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IGSF8 promoter sequence
   Search SABiosciences Chromatin IP Primers for IGSF8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGSF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q23.1

IGSF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGSF8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M160061:  view genomic region     (about GC identifiers)

Start:
 160,061,130 bp from pter      End:
 160,068,733 bp from pter
Size:
 7,604 bases      Orientation:
 minus strand

Proteins
for IGSF8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IGSF8_HUMAN, Q969P0 (See protein sequence)
Recommended Name: Immunoglobulin superfamily member 8 precursor  
Size: 613 amino acids; 65034 Da
Subunit: Interacts directly with CD82, CD81/tetraspanin-28 and CD9/tetraspanin-29. Also interacts with integrin
alpha-3/beta-1 and integrin alpha-4/beta-1
Subcellular location: Cell membrane (By similarity); Single-pass membrane protein
Secondary accessions: Q8NG09 Q96DP4 Q9BTG9
Alternative splicing: 3 isoforms:  Q969P0-1   Q969P0-2   Q969P0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IGSF8: NX_Q969P0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q969P0

    • IGSF8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001193594.1  NP_443100.1  

    ENSEMBL proteins: 
     ENSP00000316664   ENSP00000357065   ENSP00000397464  

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    Novus Biologicals IGSF8 Proteins
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IGSF8

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IDA11504738


    IGSF8 for ontologies           About GeneDecksing



    IGSF8 Antibody Products: 
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    Uscn ELISAs and CLIAs for IGSF8

    Protein Domains /
    Families
    for IGSF8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IGSF8 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR007110 Ig-like_dom
     IPR013783 Ig-like_fold
     IPR003599 Ig_sub
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q969P0

    ProtoNet protein and cluster: Q969P0

    2 Blocks protein families:
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: IGSF8_HUMAN, Q969P0
    Domain: The Ig-like C2-type domains 3 and 4 are required for interaction with CD81 (By similarity)
    Domain: The short cytoplasmic domain is very basic, interacts with membrane PIPs, and mediates plasma membrane
    localization (By similarity)
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    Function
    for IGSF8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IGSF8_HUMAN, Q969P0
    Function: May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis
    C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell
    motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell
    migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May
    also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite
    outgrowth and maintenance of the neural network in the adult brain

    miRNA
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    hsa-miR-3671 hsa-miR-548am hsa-miR-130a* hsa-miR-23c hsa-miR-7 hsa-miR-23b hsa-miR-2276 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmid: IGSF8 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11504738


    IGSF8 for ontologies           About GeneDecksing



    Pathways & Interactions
    for IGSF8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IGSF8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/28 Interacting proteins for IGSF8 (Q969P02, 3 ENSP000003166644) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD81P600332, 3, ENSP000002636454MINT-8407185 I2D: score=2 STRING: ENSP00000263645
    CD9P219262, 3, ENSP000000091804MINT-8407185 I2D: score=2 STRING: ENSP00000009180
    CD82P277013, ENSP000002271554I2D: score=2 STRING: ENSP00000227155
    ITGB1P055562, ENSP000003640944MINT-8407185 STRING: ENSP00000364094
    ADAM10O146722MINT-8407185
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement NAS11504738
    GO:0007338single fertilization NAS11504738
    GO:0007399nervous system development NAS11504738
    GO:0007519skeletal muscle tissue development NAS11504738
    GO:0008283cell proliferation NAS11504738


    IGSF8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IGSF8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IGSF8
    Search CenterWatch for drugs/clinical trials and news about IGSF8 

    Transcripts
    for IGSF8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IGSF8 gene (2 alternative transcripts): 
    NM_001206665.2  NM_052868.4  

    Unigene Cluster for IGSF8:

    Immunoglobulin superfamily, member 8
    Hs.743982  [show with all ESTs]
    Unigene Representative Sequence: BC053881
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314485(uc001fuz.3 uc009wtf.3) ENST00000368086(uc001fva.3)
    ENST00000448417 ENST00000460351

    miRNA
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    hsa-miR-3671 hsa-miR-548am hsa-miR-130a* hsa-miR-23c hsa-miR-7 hsa-miR-23b hsa-miR-2276 hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmid: IGSF8 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGSF8 (see all 6)
    OriGene siRNA: IGSF8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGSF8
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): IGSF8 (NM_052868)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGSF8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGSF8

    Additional cDNA sequence: 

    AF311906.1 AF407274.1 AK308115.1 AY044845.1 AY157579.1 BC004108.2 BC011896.2 BC023649.2 
    BC053881.1 

    11 DOTS entries:

    DT.313962  DT.97847501  DT.92437526  DT.100794622  DT.100794619  DT.100794615  DT.97791027  DT.100794620 
    DT.100794621  DT.100844795  DT.92437527 

    24/228 AceView cDNA sequences (see all 228):

    BC023649 AI948525 AI700165 BQ721029 BC004108 BF725746 AI871915 AA972364 
    BE047887 AI880215 AI367549 BU172537 BM924573 BI792019 AI810203 AY044845 
    BF438614 BQ677995 CD519647 BQ881173 BQ638965 BQ678926 BQ023721 BG743319 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for IGSF8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b
    SP1:                                                                    -         
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for IGSF8

    Expression
    for IGSF8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IGSF8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGAGGCTTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IGSF8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IGSF8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IGSF8

    SOURCE GeneReport for Unigene cluster: Hs.743982

    UniProtKB/Swiss-Prot: IGSF8_HUMAN, Q969P0
    Tissue specificity: Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other
    tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells
    and platelets

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    In Situ
    Assay Products:     
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    Orthologs
    for IGSF8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IGSF8 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Igsf81 , 5 immunoglobulin superfamily, member 81, 5 85.32(n)1
    89.03(a)1    		   1 (79.59 cM)5
    1405591  NM_080419.11  NP_536344.11 
     1722616415 
    lizard
    (Anolis carolinensis)    		 Reptilia IGSF86
    		 --
    		 50(a)
    		 1 ↔ 1
    		 GL344012.1(30725-43326)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:772221 zgc:77222 48.1(n)
    41.12(a)    		   404631  NM_207099.1  NP_996982.1 


    ENSEMBL Gene Tree for IGSF8 (if available)
    TreeFam Gene Tree for IGSF8 (if available) 

    Paralogs
    for IGSF8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IGSF8 gene
    IGSF32  CD1012  PTGFRN2  
    3 SIMAP similar genes for IGSF8 using alignment to 2 protein entries:     IGSF8_HUMAN (see all proteins):
    FLJ00271    CD101    IGSF3

    IGSF8 for paralogs           About GeneDecksing



    Genomic Variants
    for IGSF8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/194 NCBI SNPs in IGSF8 are shown (see all 194)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs120587931,2
    		C,H,--131418475(+) GAGGGC/TTTGGA 2 -- ut31 ese35Minor allele frequency- T:0.00NS EA NA 512
    rs777365361,2
    		--131420362(+) CACTAG/AGTATG 2 -- int12Minor allele frequency- A:0.17CSA WA 120
    rs1145459191,2
    		C,--131420500(+) CTGTGG/AAAGAT 2 -- int11Minor allele frequency- A:0.01WA 118
    rs1137006251,2
    		F--131420703(+) TCAGCG/AGCAGT 4 /A syn12Minor allele frequency- A:0.50CSA 8
    rs1135509451,2
    		C--131421079(+) GAACTC/GGAGAG 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs120632441,2
    		F,--131421536(+) CATTTC/ATTCTC 2 -- int1 trp31Minor allele frequency- A:0.10WA 118
    rs593668031,2
    		--131421641(+) TTGTGC/AAAATC 2 -- int12Minor allele frequency- A:0.18CSA WA 120
    rs794741921,2
    		F,--131421717(+) TGTGGC/TCTTGA 2 -- int11Minor allele frequency- T:0.04WA 118
    rs768137621,2
    		C,F,--131422211(+) CTGCCG/ACCACA 2 -- int13Minor allele frequency- A:0.18CSA WA 122
    rs730236771,2
    		C,--131422375(+) CCAGAT/GGCATC 2 -- int12Minor allele frequency- G:0.10WA 120

    HapMap Linkage Disequilibrium report for IGSF8 (160061130 - 160068733 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IGSF8: --

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    Disorders / Diseases
    for IGSF8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IGSF8 for disorders           About GeneDecksing

    OMIM gene information: 606644    OMIM disorders: --

    5 diseases for IGSF8:    About MalaCards
    hepatitis c    prostate cancer    glioblastoma    hepatitis
    prostatitis


    Export disorders for IGSF8 gene to outside databases

    Publications
    for IGSF8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IGSF8 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with IGSF8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. (PubMed id 11504738)1, 2, 3 Stipp C.S.... Hemler M.E. (2001)
    2. EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5. (PubMed id 14662754)1, 2, 9 Stipp C.S.... Hemler M.E. (2003)
    3. EWI-2 modulates lymphocyte integrin alpha4beta1 functions. (PubMed id 15070678)1, 2, 9 Kolesnikova T.V....Hemler M.E. (2004)
    4. EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. (PubMed id 12750295)1, 2, 9 Zhang X.A.... Liu L. (2003)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes. (PubMed id 12752121)1, 2 Bonkobara M.... Ariizumi K. (2003)
    8. EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells. (PubMed id 12708969)1, 2 Charrin S.... Rubinstein E. (2003)
    9. PGRL is a major CD81-associated protein on lymphocyte s and distinguishes a new family of cell surface proteins. (PubMed id 11673522)1, 3 Clark K.L....Todd S.C. (2001)
    10. EWI-2 association with a-actinin regulates T cell immu ne synapses and HIV viral infection. (PubMed id 22689882)1 Gordon-Alonso M....Yanez-Mo M. (2012)

    External Searches for IGSF8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
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    Genome Databases showing IGSF8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 93185 HGNC: 17813 AceView: IGSF8 Ensembl:ENSG00000162729 euGenes: HUgn93185
    ECgene: IGSF8 H-InvDB: IGSF8

    Other Databases showing IGSF8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IGSF8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IGSF8 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IGSF8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IGSF8 gene:
    Search GeneIP for patents involving IGSF8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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