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Aliases for IGSF6 Gene

Aliases for IGSF6 Gene

  • Immunoglobulin Superfamily Member 6 2 3 5
  • DORA 3 4
  • Down-Regulated By Activation (Immunoglobulin Superfamily) 3
  • Immunoglobulin Superfamily, Member 6 2
  • Protein DORA 4
  • IgSF6 4

External Ids for IGSF6 Gene

Previous GeneCards Identifiers for IGSF6 Gene

  • GC16M021060
  • GC16M021661
  • GC16M021619
  • GC16M021560
  • GC16M020034

Summaries for IGSF6 Gene

GeneCards Summary for IGSF6 Gene

IGSF6 (Immunoglobulin Superfamily Member 6) is a Protein Coding gene. Diseases associated with IGSF6 include Inflammatory Bowel Disease 1 and Inflammatory Bowel Disease. GO annotations related to this gene include transmembrane signaling receptor activity.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGSF6 Gene

Genomics for IGSF6 Gene

Regulatory Elements for IGSF6 Gene

Enhancers for IGSF6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G021607 1.8 FANTOM5 Ensembl ENCODE dbSUPER 28.6 +42.0 41966 5.8 ATF1 PKNOX1 ARNT TCF12 GATA2 NCOA1 MEF2D CREB3 MAFF SMARCA4 IGSF6 METTL9 ENSG00000261596 RNU6-196P RNU6-1005P CRYM ERI2 PIR54824
GH16G021597 1.8 FANTOM5 ENCODE dbSUPER 20.8 +53.1 53100 4.6 MLX CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D METTL9 IGSF6 NPIPB5 THUMPD1 CRYM LOC101927814 PIR54824
GH16G021644 1.8 FANTOM5 Ensembl ENCODE dbSUPER 19.1 +4.9 4857 7.6 HDGF FOXA2 PKNOX1 WRNIP1 YY1 TCF12 ZNF207 DEK JUNB REST METTL9 IGSF6 ENSG00000260905 CRYM GC16P021651 RNU6-196P
GH16G021624 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.6 +25.1 25145 6.3 HNRNPUL1 PKNOX1 FOXA2 SIN3A ARID4B DMAP1 ZNF48 SLC30A9 FOS SP5 METTL9 IGSF6 ENSG00000260905 ENSG00000260973 CRYM ENSG00000261596 GC16P021642
GH16G021589 1.2 Ensembl ENCODE dbSUPER 11.4 +61.7 61721 2.7 ZNF639 ZSCAN4 HLF CEBPB ZNF384 CEBPG ZBTB40 ZGPAT PRDM6 GLIS1 RNU6-1005P RNU6-196P IGSF6 OTOA ENSG00000252798 METTL9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGSF6 on UCSC Golden Path with GeneCards custom track

Promoters for IGSF6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000084380 565 599 EZH2

Genomic Location for IGSF6 Gene

Chromosome:
16
Start:
21,639,537 bp from pter
End:
21,652,666 bp from pter
Size:
13,130 bases
Orientation:
Minus strand

Genomic View for IGSF6 Gene

Genes around IGSF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGSF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGSF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGSF6 Gene

Proteins for IGSF6 Gene

  • Protein details for IGSF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95976-IGSF6_HUMAN
    Recommended name:
    Immunoglobulin superfamily member 6
    Protein Accession:
    O95976
    Secondary Accessions:
    • Q8WWD8

    Protein attributes for IGSF6 Gene

    Size:
    241 amino acids
    Molecular mass:
    27013 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This gene is localized to a locus associated with inflammatory bowel disease. It is coded entirely within the intron of METTL9 which is transcribed in the opposite strand of the DNA.

neXtProt entry for IGSF6 Gene

Post-translational modifications for IGSF6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGSF6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGSF6 Gene

Domains & Families for IGSF6 Gene

Gene Families for IGSF6 Gene

Protein Domains for IGSF6 Gene

Suggested Antigen Peptide Sequences for IGSF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGSF6: view

No data available for UniProtKB/Swiss-Prot for IGSF6 Gene

Function for IGSF6 Gene

Molecular function for IGSF6 Gene

UniProtKB/Swiss-Prot Induction:
By TNF and CSF2/GM-CSF in dendritic cells and down regulation by phorbol myristate acetate (PMA) and ionomycin in monocytes.

Gene Ontology (GO) - Molecular Function for IGSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 9809579
genes like me logo Genes that share ontologies with IGSF6: view
genes like me logo Genes that share phenotypes with IGSF6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IGSF6

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGSF6 Gene

Localization for IGSF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGSF6 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGSF6 gene
Compartment Confidence
plasma membrane 5
extracellular 3

Gene Ontology (GO) - Cellular Components for IGSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9809579
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IGSF6: view

Pathways & Interactions for IGSF6 Gene

SuperPathways for IGSF6 Gene

No Data Available

Interacting Proteins for IGSF6 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000268389%0d%0a9606.ENSP00000399168%0d%0a9606.ENSP00000364114%0d%0a9606.ENSP00000431254%0d%0a9606.ENSP00000378786%0d%0a9606.ENSP00000385361%0d%0a
Selected Interacting proteins: O95976-IGSF6_HUMAN ENSP00000268389 for IGSF6 Gene via IID STRING

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-DRB1
HLA-DRA
HLA-DRB5

Gene Ontology (GO) - Biological Process for IGSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 9809579
GO:0007166 cell surface receptor signaling pathway TAS 9809579
genes like me logo Genes that share ontologies with IGSF6: view

No data available for Pathways by source and SIGNOR curated interactions for IGSF6 Gene

Drugs & Compounds for IGSF6 Gene

No Compound Related Data Available

Transcripts for IGSF6 Gene

mRNA/cDNA for IGSF6 Gene

Unigene Clusters for IGSF6 Gene

Immunoglobulin superfamily, member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGSF6 Gene

No ASD Table

Relevant External Links for IGSF6 Gene

GeneLoc Exon Structure for
IGSF6
ECgene alternative splicing isoforms for
IGSF6

Expression for IGSF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGSF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGSF6 Gene

This gene is overexpressed in Whole Blood (x38.3) and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for IGSF6 Gene

This gene is overexpressed in Monocytes (60.9) and Spleen (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGSF6 Gene



Protein tissue co-expression partners for IGSF6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGSF6 Gene:

IGSF6

SOURCE GeneReport for Unigene cluster for IGSF6 Gene:

Hs.530902

mRNA Expression by UniProt/SwissProt for IGSF6 Gene:

O95976-IGSF6_HUMAN
Tissue specificity: Expressed in peripheral blood lymphocytes, spleen and lymph node, with low levels in thymus, bone marrow and fetal liver. No expression in non-immune tissues.

Evidence on tissue expression from TISSUES for IGSF6 Gene

  • Lung(4.2)
  • Spleen(2.5)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with IGSF6: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IGSF6 Gene

Orthologs for IGSF6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGSF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGSF6 34 35
  • 99.17 (n)
rat
(Rattus norvegicus)
Mammalia Igsf6 34
  • 77.73 (n)
dog
(Canis familiaris)
Mammalia IGSF6 34 35
  • 76.53 (n)
mouse
(Mus musculus)
Mammalia Igsf6 34 16 35
  • 75.85 (n)
cow
(Bos Taurus)
Mammalia IGSF6 34 35
  • 75.81 (n)
oppossum
(Monodelphis domestica)
Mammalia IGSF6 35
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGSF6 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGSF6 34 35
  • 51.18 (n)
lizard
(Anolis carolinensis)
Reptilia IGSF6 35
  • 36 (a)
OneToOne
Species where no ortholog for IGSF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGSF6 Gene

ENSEMBL:
Gene Tree for IGSF6 (if available)
TreeFam:
Gene Tree for IGSF6 (if available)

Paralogs for IGSF6 Gene

No data available for Paralogs for IGSF6 Gene

Variants for IGSF6 Gene

Sequence variations from dbSNP and Humsavar for IGSF6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000074434 -- 21,651,162(+) AGCTT(G/T)CAGTG intron-variant
rs1000353048 -- 21,645,206(+) CCAGC(A/G)CTTTG intron-variant
rs1000364239 -- 21,640,839(+) CCCAC(A/G)TCTTC intron-variant
rs1000371358 -- 21,648,367(+) TGTGA(C/T)GTTCA intron-variant
rs1000422104 -- 21,647,954(+) GGAGC(C/T)TATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGSF6 Gene

Variant ID Type Subtype PubMed ID
dgv116e55 CNV loss 17911159
dgv2800n100 CNV gain 25217958
dgv2803n100 CNV loss 25217958
dgv2804n100 CNV gain 25217958
dgv2805n100 CNV gain+loss 25217958
dgv2806n100 CNV gain 25217958
dgv2807n100 CNV loss 25217958
dgv2808n100 CNV gain+loss 25217958
dgv2809n100 CNV loss 25217958
dgv2810n100 CNV loss 25217958
dgv347n27 CNV gain 19166990
dgv348n27 CNV loss 19166990
dgv3n1 OTHER inversion 15895083
dgv3n29 CNV loss 16826518
dgv47n16 OTHER inversion 17901297
dgv4944n54 CNV loss 21841781
dgv4946n54 CNV gain+loss 21841781
dgv4947n54 CNV loss 21841781
dgv806e212 CNV loss 25503493
esv25717 CNV gain+loss 19812545
esv2751551 CNV gain 17911159
esv2751552 CNV loss 17911159
esv2758636 CNV gain+loss 17122850
esv2762010 CNV gain+loss 21179565
esv2763135 CNV gain 21179565
esv3368991 OTHER inversion 20981092
esv34235 CNV gain 17911159
esv3427100 CNV insertion 20981092
esv34544 CNV gain 17911159
esv3570431 CNV gain 25503493
esv3582094 CNV loss 25503493
esv3638186 CNV loss 21293372
esv3638187 CNV gain 21293372
esv3892812 CNV gain+loss 25118596
esv998989 OTHER inversion 20482838
nsv1077770 OTHER inversion 25765185
nsv1140248 OTHER inversion 24896259
nsv428322 CNV gain 18775914
nsv433438 CNV gain 18776910
nsv471086 CNV loss 18288195
nsv499139 OTHER inversion 21111241
nsv517713 CNV gain+loss 19592680
nsv571631 CNV loss 21841781
nsv571634 CNV gain 21841781
nsv571635 CNV gain 21841781
nsv571639 CNV loss 21841781
nsv7280 OTHER inversion 18451855
nsv817726 CNV gain 17921354
nsv9397 CNV gain+loss 18304495

Variation tolerance for IGSF6 Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGSF6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGSF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGSF6 Gene

Disorders for IGSF6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for IGSF6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease 1
  • crohn disease-associated growth failure
inflammatory bowel disease
  • inflammatory bowel diseases
dysbaric osteonecrosis
  • caisson disease of bone
- elite association - COSMIC cancer census association via MalaCards
Search IGSF6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IGSF6

Genetic Association Database (GAD)
IGSF6
Human Genome Epidemiology (HuGE) Navigator
IGSF6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IGSF6
genes like me logo Genes that share disorders with IGSF6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGSF6 Gene

Publications for IGSF6 Gene

  1. Genetic variation in the IGSF6 gene and lack of association with inflammatory bowel disease. (PMID: 12786995) King K. … Mathew C.G. (Eur. J. Immunogenet. 2003) 3 4 46 64
  2. The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function. (PMID: 11132146) Bates E.E.M. … Lebecque S. (Immunogenetics 2000) 3 4 22 64
  3. CD40L activation of dendritic cells down-regulates DORA, a novel member of the immunoglobulin superfamily. (PMID: 9809579) Bates E.E.M. … Lebecque S. (Mol. Immunol. 1998) 2 3 4 64
  4. Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. (PMID: 23898208) Johnson T.P. … Nath A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 64
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64

Products for IGSF6 Gene

Sources for IGSF6 Gene

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