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Aliases for IGSF6 Gene

Aliases for IGSF6 Gene

  • Immunoglobulin Superfamily Member 6 2 3 5
  • Immunoglobulin Superfamily, Member 6 2 3
  • DORA 3 4
  • Down-Regulated By Activation (Immunoglobulin Superfamily) 3
  • Protein DORA 4
  • IgSF6 4

External Ids for IGSF6 Gene

Previous GeneCards Identifiers for IGSF6 Gene

  • GC16M021060
  • GC16M021661
  • GC16M021619
  • GC16M021560
  • GC16M020034

Summaries for IGSF6 Gene

GeneCards Summary for IGSF6 Gene

IGSF6 (Immunoglobulin Superfamily Member 6) is a Protein Coding gene. Diseases associated with IGSF6 include Inflammatory Bowel Disease 1 and Dysbaric Osteonecrosis. GO annotations related to this gene include transmembrane signaling receptor activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGSF6 Gene

Genomics for IGSF6 Gene

Regulatory Elements for IGSF6 Gene

Enhancers for IGSF6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IGSF6 on UCSC Golden Path with GeneCards custom track

Promoters for IGSF6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IGSF6 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGSF6 Gene

21,639,537 bp from pter
21,652,666 bp from pter
13,130 bases
Minus strand

Genomic View for IGSF6 Gene

Genes around IGSF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGSF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGSF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGSF6 Gene

Proteins for IGSF6 Gene

  • Protein details for IGSF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin superfamily member 6
    Protein Accession:
    Secondary Accessions:
    • Q8WWD8

    Protein attributes for IGSF6 Gene

    241 amino acids
    Molecular mass:
    27013 Da
    Quaternary structure:
    No Data Available
    • This gene is localized to a locus associated with inflammatory bowel disease. It is coded entirely within the intron of METTL9 which is transcribed in the opposite strand of the DNA.

neXtProt entry for IGSF6 Gene

Proteomics data for IGSF6 Gene at MOPED

Post-translational modifications for IGSF6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGSF6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGSF6 Gene

Domains & Families for IGSF6 Gene

Gene Families for IGSF6 Gene

Protein Domains for IGSF6 Gene

Suggested Antigen Peptide Sequences for IGSF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGSF6: view

Function for IGSF6 Gene

Molecular function for IGSF6 Gene

UniProtKB/Swiss-Prot Induction:
By TNF and CSF2/GM-CSF in dendritic cells and down regulation by phorbol myristate acetate (PMA) and ionomycin in monocytes.
genes like me logo Genes that share phenotypes with IGSF6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IGSF6

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGSF6 Gene

Localization for IGSF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGSF6 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for IGSF6 Gene COMPARTMENTS Subcellular localization image for IGSF6 gene
Compartment Confidence
plasma membrane 5
extracellular 3

No data available for Gene Ontology (GO) - Cellular Components for IGSF6 Gene

Pathways & Interactions for IGSF6 Gene

SuperPathways for IGSF6 Gene

No Data Available

Interacting Proteins for IGSF6 Gene

Gene Ontology (GO) - Biological Process for IGSF6 Gene


No data available for Pathways by source and SIGNOR curated interactions for IGSF6 Gene

Drugs & Compounds for IGSF6 Gene

No Compound Related Data Available

Transcripts for IGSF6 Gene

mRNA/cDNA for IGSF6 Gene

Unigene Clusters for IGSF6 Gene

Immunoglobulin superfamily, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGSF6 Gene

No ASD Table

Relevant External Links for IGSF6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGSF6 Gene

mRNA expression in normal human tissues for IGSF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGSF6 Gene

This gene is overexpressed in Whole Blood (x38.3) and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for IGSF6 Gene

This gene is overexpressed in Monocytes (60.9) and Spleen (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGSF6 Gene

SOURCE GeneReport for Unigene cluster for IGSF6 Gene Hs.530902

mRNA Expression by UniProt/SwissProt for IGSF6 Gene

Tissue specificity: Expressed in peripheral blood lymphocytes, spleen and lymph node, with low levels in thymus, bone marrow and fetal liver. No expression in non-immune tissues.
genes like me logo Genes that share expression patterns with IGSF6: view

Protein tissue co-expression partners for IGSF6 Gene

- Elite partner

Primer Products

Orthologs for IGSF6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGSF6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IGSF6 35
  • 75.81 (n)
  • 64.14 (a)
IGSF6 36
  • 63 (a)
(Canis familiaris)
Mammalia IGSF6 35
  • 76.53 (n)
  • 67.5 (a)
IGSF6 36
  • 67 (a)
(Mus musculus)
Mammalia Igsf6 35
  • 75.85 (n)
  • 63.14 (a)
Igsf6 16
Igsf6 36
  • 62 (a)
(Pan troglodytes)
Mammalia IGSF6 35
  • 99.17 (n)
  • 99.59 (a)
IGSF6 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Igsf6 35
  • 77.73 (n)
  • 67.23 (a)
(Monodelphis domestica)
Mammalia IGSF6 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia IGSF6 36
  • 50 (a)
(Gallus gallus)
Aves IGSF6 35
  • 51.18 (n)
  • 37.17 (a)
IGSF6 36
  • 38 (a)
(Anolis carolinensis)
Reptilia IGSF6 36
  • 36 (a)
Species with no ortholog for IGSF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGSF6 Gene

Gene Tree for IGSF6 (if available)
Gene Tree for IGSF6 (if available)

Paralogs for IGSF6 Gene

No data available for Paralogs for IGSF6 Gene

Variants for IGSF6 Gene

Sequence variations from dbSNP and Humsavar for IGSF6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_039137 -
VAR_039138 -
VAR_039139 -

Structural Variations from Database of Genomic Variants (DGV) for IGSF6 Gene

Variant ID Type Subtype PubMed ID
esv34235 CNV Gain 17911159
dgv830e1 CNV Complex 17122850
esv25717 CNV Gain+Loss 19812545
nsv433438 CNV Gain 18776910
nsv905579 CNV Gain 21882294
nsv9397 CNV Gain+Loss 18304495
dgv2642n71 CNV Loss 21882294
dgv831e1 CNV Complex 17122850
dgv832e1 CNV Complex 17122850
nsv428322 CNV Gain 18775914
dgv2643n71 CNV Gain 21882294
esv2751551 CNV Gain 17911159
esv34544 CNV Gain 17911159
esv2751552 CNV Loss 17911159
dgv116e55 CNV Loss 17911159
nsv7280 OTHER Inversion 18451855
dgv347n27 CNV Gain 19166990
dgv348n27 CNV Loss 19166990
nsv471086 CNV Loss 18288195
nsv517713 CNV Gain+Loss 19592680
nsv817726 CNV Gain 17921354
dgv2644n71 CNV Loss 21882294
dgv3n1 OTHER Inversion 15895083
nsv511047 OTHER Inversion 20534489
dgv2645n71 CNV Gain+Loss 21882294
dgv2646n71 CNV Gain 21882294
nsv905590 CNV Gain 21882294
dgv47n16 OTHER Inversion 17901297
nsv499139 OTHER Inversion 21111241
esv998989 OTHER Inversion 20482838
dgv2n29 CNV Loss 16826518
dgv833e1 CNV Complex 17122850
essv3313 CNV CNV 17122850

Variation tolerance for IGSF6 Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.40% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IGSF6 Gene

Disorders for IGSF6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IGSF6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease 1
  • crohn disease-associated growth failure
dysbaric osteonecrosis
  • caisson disease of bone
- elite association - COSMIC cancer census association via MalaCards
Search IGSF6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IGSF6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IGSF6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGSF6 Gene

Publications for IGSF6 Gene

  1. Genetic variation in the IGSF6 gene and lack of association with inflammatory bowel disease. (PMID: 12786995) King K. … Mathew C.G. (Eur. J. Immunogenet. 2003) 3 4 48 67
  2. The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function. (PMID: 11132146) Bates E.E.M. … Lebecque S. (Immunogenetics 2000) 3 23
  3. CD40L activation of dendritic cells down-regulates DORA, a novel member of the immunoglobulin superfamily. (PMID: 9809579) Bates E.E.M. … Lebecque S. (Mol. Immunol. 1998) 2 3
  4. Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. (PMID: 23898208) Johnson T.P. … Nath A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for IGSF6 Gene

Sources for IGSF6 Gene