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IGSF5 Gene

protein-coding   GIFtS: 51
GCID: GC21P041117

Immunoglobulin Superfamily, Member 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Immunoglobulin Superfamily, Member 51 2     GSF52
Junctional Adhesion Molecule 41 2 3     Immunoglobulin Superfamily 5 Like2
JAM42 3 5     Immunoglobulin Superfamily Member 52
JAM-42 3     IgSF53
Putative Gene, Immunoglobulin Superfamily 5 Like11     

External Ids:    HGNC: 59521   Entrez Gene: 1500842   Ensembl: ENSG000001830677   OMIM: 6106385   UniProtKB: Q9NSI53   

Export aliases for IGSF5 gene to outside databases

Previous GC identifers: GC21U990047 GC21P040040 GC21P026586


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IGSF5 Gene:
IGSF5 (immunoglobulin superfamily, member 5) is a protein-coding gene. Diseases associated with IGSF5 include coronary heart disease, and choroiditis. GO annotations related to this gene include PDZ domain binding.

UniProtKB/Swiss-Prot: IGSF5_HUMAN, Q9NSI5
Function: Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the
permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic
cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It
may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli
cells-Sertoli cells (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence:
NC_000021.9  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IGSF5 gene promoter:
         Elk-1   RFX1   CUTL1   c-Ets-1   AREB6   POU2F1   Ik-2   POU2F1a   STAT3   Ik-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

   Search Chromatin IP Primers for IGSF5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGSF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.2   Ensembl cytogenetic band:  21q22.2   HGNC cytogenetic band: 21q22.2
Nature(405: 311-319) cytogenetic band:   21q22.2
IGSF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGSF5 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P041117:   GeneLoc Nature:405,311-319
Start:
41,117,334 bp from pter       26,710,455 bp from centromere
End:
41,174,023 bp from pter 26,737,020 bp from centromere
Size:
56,690 bases 26,566 bases
Orientation:
plus strand plus strand

genomic clones: P206A10 BAC-291B3


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IGSF5_HUMAN, Q9NSI5 (See protein sequence)
Recommended Name: Immunoglobulin superfamily member 5  
Size: 407 amino acids; 44593 Da
Subunit: Interacts with MAGI1 at tight junctions, forms a tripartite complex with NPHS1 (By similarity). Interacts
with LNX1 isoform 2 via its PDZ 2 domain, it may also interact with other isoforms containing this domain (By
similarity)
Miscellaneous: A protein of the expected size has been detected by antibody binding and Western blot in at least
one of the analyzed tissues or cells (PubMed:22042635)
Sequence caution: Sequence=CAB90447.1; Type=Erroneous gene model prediction;

Explore the universe of human proteins at neXtProt for IGSF5: NX_Q9NSI5

Explore proteomics data for IGSF5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn59, Asn103, Asn210, Asn231
  • Modification sites at PhosphoSitePlus

  • See IGSF5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073913.1  
    ENSEMBL proteins: 
     ENSP00000369962  

    IGSF5 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
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    OriGene Custom Protein Services for IGSF5
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IGSF5

    IGSF5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for IGSF5 (JAM-4/IGSF5)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IGSF5
    Abcam antibodies for IGSF5
    Cloud-Clone Corp. Antibodies for IGSF5
    ThermoFisher Antibodies for IGSF5
    LSBio Antibodies in human, mouse, rat for IGSF5

    IGSF5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IGSF5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IGSF5
    Cloud-Clone Corp. CLIAs for IGSF5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    4 InterPro protein domains:
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9NSI5

    ProtoNet protein and cluster: Q9NSI5

    1 Blocks protein domain: IPB013098 Immunoglobulin I-set

    UniProtKB/Swiss-Prot: IGSF5_HUMAN, Q9NSI5
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    IGSF5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IGSF5_HUMAN, Q9NSI5
    Function: Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the
    permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic
    cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It
    may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli
    cells-Sertoli cells (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0030165PDZ domain binding IEA--
         
    IGSF5 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Igsf5):
     normal 

    IGSF5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Igsf5tm1Ohbo for IGSF5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IGSF5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IGSF5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGSF5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGSF5

    miRNA
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    Block miRNA regulation of human, mouse, rat IGSF5 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate IGSF5:
    hsa-miR-3659 hsa-miR-122 hsa-miR-145
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IGSF5
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    Gene Editing
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    Clone
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    OriGene clones in human, mouse for IGSF5 (see all 9)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IGSF5 (NM_001080444)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGSF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGSF5

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGSF5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IGSF5_HUMAN, Q9NSI5: Cell membrane; Single-pass membrane protein (By similarity). Cell junction, tight junction
    (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol2
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005923tight junction IEA--
    GO:0009986cell surface IEA--
    GO:0016021integral component of membrane IEA--

    IGSF5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IGSF5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Insulin receptor recycling
    Epithelial cell signaling in Helicobacter pylori infection0.32
    2Tight junction
    Tight junction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for IGSF5):
        Tight junction
    Epithelial cell signaling in Helicobacter pylori infection


    IGSF5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including IGSF5: 
              Tight Junctions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IGSF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for IGSF5 (Q9NSI53 ENSP000003699624) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LNX1Q8TBB13, ENSP000002639254I2D: score=1 STRING: ENSP00000263925
    MAGI1Q96QZ73, ENSP000003854504I2D: score=1 STRING: ENSP00000385450
    ENSG00000270149ENSP000002897794STRING: ENSP00000289779
    JAM2ENSP000004204194STRING: ENSP00000420419
    JAM3ENSP000002991064STRING: ENSP00000299106
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016337cell-cell adhesion IEA--

    IGSF5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGSF5

    1 HMDB Compound for IGSF5    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IGSF5 gene: 
    NM_001080444.1  

    Unigene Cluster for IGSF5:

    Immunoglobulin superfamily, member 5
    Hs.422120  [show with all ESTs]
    Unigene Representative Sequence: NM_001080444
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380588(uc002yyo.3) ENST00000479378 ENST00000459922
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IGSF5 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate IGSF5:
    hsa-miR-3659 hsa-miR-122 hsa-miR-145
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat IGSF5
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    GenScript: all cDNA clones in your preferred vector: IGSF5 (NM_001080444)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGSF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGSF5
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat IGSF5
      QuantiTect SYBR Green Assays in human, mouse, rat IGSF5
      QuantiFast Probe-based Assays in human, mouse, rat IGSF5

    Additional mRNA sequence: 

    AK092516.1 BC114922.1 

    4 DOTS entries:

    DT.65287186  DT.100727452  DT.100728552  DT.105698 

    16 AceView cDNA sequences:

    AI582634 CR606754 N73563 BX403420 AI824021 BG740428 N47851 BX370118 
    BX358190 BX399881 AX747579 AK092516 N93995 AJ003329 BG206666 BX370209 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGSF5 expression in normal human tissues (normalized intensities)      IGSF5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IGSF5 Expression
    About this image


    IGSF5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Medulla Oblongata
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Metencephalon
    IGSF5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGSF5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.422120
        Pathway & Disease-focused RT2 Profiler PCR Array including IGSF5: 
              Tight Junctions in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for IGSF5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGSF5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IGSF5 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igsf51 , 5 immunoglobulin superfamily, member 51, 5 66(n)1
    53.98(a)1
      16 (56.93 cM)5
    720581  NM_001177887.11  NP_001171358.11 
     963616685 
    chicken
    (Gallus gallus)
    Aves IGSF51 immunoglobulin superfamily, member 5 48.96(n)
    34.75(a)
      418524  XM_004934559.1  XP_004934616.1 
    lizard
    (Anolis carolinensis)
    Reptilia IGSF56
    immunoglobulin superfamily, member 5
    30(a)
    1 ↔ 1
    3(139451806-139500528)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia igsf51 immunoglobulin superfamily, member 5 45.99(n)
    34.13(a)
      100495273  XM_002938737.2  XP_002938783.2 
    zebrafish
    (Danio rerio)
    Actinopterygii igsf5a1 immunoglobulin superfamily, member 5a 44.91(n)
    31.05(a)
      561211  XM_684617.6  XP_689709.3 


    ENSEMBL Gene Tree for IGSF5 (if available)
    TreeFam Gene Tree for IGSF5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IGSF5 (see all 1740)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs745075631,2
    C--41115396(+) AAAAGG/TTACAT 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs789658251,2
    C--41115431(+) CTCCTT/CCCGCT 1 -- us2k12Minor allele frequency- C:0.33NA CSA 3
    rs792079771,2
    C--41115445(+) TGGAGA/GGGGCA 1 -- us2k12Minor allele frequency- G:0.33NA CSA 3
    rs1914529101,2
    --41115458(+) ATCGGA/GGAATA 1 -- us2k10--------
    rs777329801,2
    C--41115471(+) GGCACC/TCTTTG 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1827859631,2
    --41115500(+) TGTCTA/GTCTCC 1 -- us2k10--------
    rs1871419641,2
    C--41115518(+) CCATTC/TGGGCT 1 -- us2k10--------
    rs2010355731,2
    --41115527(+) CTGAA-/GAGGGGGT 1 -- us2k10--------
    rs16212321,2
    C,F,H--41115528(+) tgaagA/C/Gggggg 1 -- us2k1 trp316NS EA NA WA CSA 1434
    rs343170561,2
    C,F--41115558(+) GAGTC-/AGGGGG 1 -- us2k13Minor allele frequency- A:0.33NA CSA 6

    HapMap Linkage Disequilibrium report for IGSF5 (41117334 - 41174023 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IGSF5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834099CNV Loss17160897
    nsv828877CNV Gain20364138
    esv275236CNV Gain+Loss21479260

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IGSF5
    DNA2.0 Custom Variant and Variant Library Synthesis for IGSF5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610638    OMIM disorders: --

    3 diseases for IGSF5:    About MalaCards
    coronary heart disease    choroiditis    parkinson's disease


    IGSF5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IGSF5
    Human Genome Epidemiology (HuGE) Navigator: IGSF5 (1 document)

    Export disorders for IGSF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGSF5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with IGSF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PubMed id 21347282)1, 4 Lettre G....Boerwinkle E. (PLoS Genet. 2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    5. Antibody-based protein profiling of the human chromosome 21. (PubMed id 22042635)2 Uhlen M....Sivertsson A. (Mol. Cell. Proteomics 2012)
    6. Genome-wide association study of suicide attempts in mood disorder patients. (PubMed id 21041247)1 Perlis R.H....Smoller J.W. (Am J Psychiatry 2010)
    7. Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data. (PubMed id 17052657)4 Fung H.C....Singleton A. (Lancet Neurol 2006)
    8. Ligand-of-Numb protein X is an endocytic scaffold for junctional adhesion molecule 4. (PubMed id 16832352)1 Kansaku A....Hata Y. (Oncogene 2006)
    9. JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1. (PubMed id 12773569)1 Hirabayashi S.... Hata Y. (Mol. Cell. Biol. 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 150084 HGNC: 5952 AceView: LOC150084 Ensembl:ENSG00000183067 euGenes: HUgn150084
    ECgene: IGSF5 Kegg: 150084 H-InvDB: IGSF5

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IGSF5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGSF5 gene:
    Search GeneIP for patents involving IGSF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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