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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IGSF3 Gene

protein-coding GIFtS: 53
GCID: GC01M117117

immunoglobulin superfamily, member 3

Explore 12 diseases affiliated with
IGSF3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Immunoglobulin Superfamily, Member 3¹ ²		Immunoglobin Superfamily, Member 3²
EWI-3¹ ² ³		Immunoglobulin Superfamily Member 3²
V8¹ ²		EWI3³
Glu-Trp-Ile EWI Motif-Containing Protein 3² ³		IgSF3³
MGC117164¹		KIAA0466³

External Ids:	HGNC: 5950¹	Entrez Gene: 3321²	Ensembl: ENSG00000143061⁷	OMIM: 603491⁵	UniProtKB: O75054³

Export aliases for IGSF3 gene to outside databases

Previous GC identifers: GC01M117619 GC01M115999 GC01M116264 GC01M116466 GC01M116829 GC01M116918 GC01M114976

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IGSF3 gene promoter:
HOXA9 HOXA9B AML1a Arnt Meis-1b PPAR-gamma1 PPAR-gamma2 Ik-1 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IGSF3 promoter sequence

Search SABiosciences Chromatin IP Primers for IGSF3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGSF3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13 Ensembl cytogenetic band: 1p13.1 HGNC cytogenetic band: 1p13

IGSF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGSF3 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M117117: view genomic region (about GC identifiers)

Start:	117,117,031 bp from pter	End:	117,210,375 bp from pter
Size:	93,345 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IGSF3_HUMAN, O75054 (See protein sequence)

Recommended Name: Immunoglobulin superfamily member 3 precursor

Size: 1194 amino acids; 135196 Da

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Miscellaneous: Likely interchromosomal Alu-mediated fusion between IGSF3 on 1p13.1 and GGT on 22q11.2. Breakpoints

occurred inside Alu elements as well as in the 5' or 3' ends of them

Sequence caution: Sequence=AAC72013.1; Type=Frameshift; Positions=829, 861; Sequence=BAA32311.2; Type=Erroneous

initiation;

Secondary accessions: A6NMC7

Alternative splicing: 2 isoforms: O75054-1 O75054-2

Explore the universe of human proteins at neXtProt for IGSF3: NX_O75054

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75054

IGSF3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001007238.1 NP_001533.2

ENSEMBL proteins:

ENSP00000358498 ENSP00000321184 ENSP00000358495

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: IGSF3 OriGene Protein Over-expression Lysate: IGSF3 OriGene Custom Protein Services for IGSF3
	GenScript Custom Purified and Recombinant Proteins Services for IGSF3
	Novus Biologicals IGSF3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for IGSF3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

IGSF3 for ontologies About GeneDecksing

IGSF3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for IGSF3
	OriGene Antibodies: IGSF3 OriGene Custom Antibody Services for IGSF3
	GenScript Custom Superior Antibodies Services for IGSF3
	Novus Biologicals IGSF3 Antibody
	Search for Antibodies for IGSF3 at Abcam
	Uscn Antibodies for IGSF3
	ThermoFisher Antibodies for IGSF3

Assay Products for IGSF3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for IGSF3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IGSF3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IGSF3 for domains About GeneDecksing

4 InterPro domains/families:

IPR007110 Ig-like_dom

IPR013783 Ig-like_fold

IPR003599 Ig_sub

IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry O75054

ProtoNet protein and cluster: O75054

2 Blocks protein families:

IPB003599 Immunoglobulin subtype

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: IGSF3_HUMAN, O75054

Similarity: Contains 8 Ig-like C2-type (immunoglobulin-like) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for IGSF3:

immunoglobulin superfamily member 3,highly expressed in placenta,kidney and lung

miRNA Products:		OriGene 3'-UTR Clone (see all 2): IGSF3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGSF3
		8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate IGSF3 (see all 88):
		hsa-miR-140-5p hsa-miR-548j hsa-miR-576-3p hsa-miR-323-3p hsa-miR-193a-3p hsa-miR-640 hsa-miR-607 hsa-miR-376b

		SwitchGear 3'UTR luciferase reporter plasmid: IGSF3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGSF3 (see all 6) OriGene siRNA: IGSF3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGSF3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for IGSF3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGSF3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGSF3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): IGSF3 (NM_001007237)
		Sino Biological Human cDNA Clone for IGSF3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGSF3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGSF3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IGSF3
		Search LifeMap BioReagents cell lines for IGSF3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGSF3

1 GenomeRNAi human phenotype for IGSF3:

Low eccentricity cells

Animal Models:
1 MGI phenotypic allele

for Igsf3 (no phenotypes)

IGSF3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IGSF3

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for IGSF3 (ENSP00000321184⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD101	ENSP00000256652⁴	STRING: ENSP00000256652
--	ENSP00000400255⁴	STRING: ENSP00000400255

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGSF3
Search CenterWatch for drugs/clinical trials and news about IGSF3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IGSF3 gene (2 alternative transcripts):

NM_001007237.1 NM_001542.2

Unigene Cluster for IGSF3:

Immunoglobulin superfamily, member 3

Hs.171057 [show with all ESTs]

Unigene Representative Sequence: NM_001542

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000369486(uc001egr.1) ENST00000318837(uc001egs.1) ENST00000481589

ENST00000369483(uc001egq.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): IGSF3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGSF3
		8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate IGSF3 (see all 88):
		hsa-miR-140-5p hsa-miR-548j hsa-miR-576-3p hsa-miR-323-3p hsa-miR-193a-3p hsa-miR-640 hsa-miR-607 hsa-miR-376b

		SwitchGear 3'UTR luciferase reporter plasmid: IGSF3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGSF3 (see all 6) OriGene siRNA: IGSF3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGSF3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGSF3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGSF3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): IGSF3 (NM_001007237)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGSF3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGSF3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGSF3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IGSF3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGSF3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGSF3

Additional cDNA sequence:

AB007935.2 AF031174.1 AK097809.1 BC071861.1 BC110651.1 BC130279.1 BC144132.1

5 DOTS entries:

DT.455074 DT.95375731 DT.100780948 DT.95200793 DT.95375732

24/227 AceView cDNA sequences (see all 227):

AL699798 AI002566 BM720675 AI039684 BF476477 CB305534 BE276898 AI161308

AB007935 AA425437 BE891030 AW378564 AI633842 BF149247 T34388 AI202838

CA428090 AA235015 AI818868 BU688482 BI492206 AA594800 AL523806 AW236948

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGSF3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGTAGAGAG

About this image

IGSF3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 8 LifeMap Cells

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IGSF3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGSF3

SOURCE GeneReport for Unigene cluster: Hs.171057

UniProtKB/Swiss-Prot: IGSF3_HUMAN, O75054

Tissue specificity: Expressed in a wide range of tissues with High expression in Placenta, kidney and lung

SABiosciences Custom PCR Arrays for IGSF3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGSF3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat IGSF3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGSF3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGSF3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGSF3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IGSF3 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	IGSF3¹	immunoglobulin superfamily, member 3	76.36(n) 76.4(a)		418451 XM_416662.3 XP_416662.3
lizard (Anolis carolinensis)	Reptilia	IGSF3⁶	--	72(a)	1 ↔ 1	3(162474568-162574687)
African clawed frog (Xenopus laevis)	Amphibia	Xl.16592²	Xenopus laevis transcribed sequence with weak similarity more	85.97(n)		CD361705.1
zebrafish (Danio rerio)	Actinopterygii	si:ch211-247j6.1¹	si:ch211-247j6.1	58.69(n) 51.81(a)		557878 NM_001159666.1 NP_001153138.1

ENSEMBL Gene Tree for IGSF3 (if available)
TreeFam Gene Tree for IGSF3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IGSF3 gene

IGSF8² CD101² PTGFRN²

3 SIMAP similar genes for IGSF3 using alignment to 2 protein entries: IGSF3_HUMAN (see all proteins):

CD101 FLJ00271 IGSF8

IGSF3 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for IGSF3
PGOHUM00000246222 PGOHUM00000246259 PGOHUM00000240768

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs184873499^1,2		--	117116546(+)	`TCCCCA/GCTGCA`	2	--	ds500¹		0	--	--	--	--
rs189243105^1,2		--	117116674(+)	`CCCCAA/CCCCCC`	2	--	ds500¹		0	--	--	--	--
rs181656157^1,2		--	117116681(+)	`CCCCAA/GCAAAA`	2	--	ds500¹		0	--	--	--	--
rs113373147^1,2		--	117116807(+)	`TTACTG/ATATGT`	2	--	ds500¹		1		CSA	2
rs185738553^1,2		--	117117029(+)	`CAGCCA/GTATTT`	2	--	ds500¹		0	--	--	--	--
rs142424788^1,2		--	117117062(+)	`TCTGAA/CGTGTA`	2	--	ut3¹		0	--	--	--	--
rs201510658^1,2		--	117117110(+)	`CCTTT-/AAAAAA`	2	--	ut3¹		0	--	--	--	--
rs11553409^1,2	C	--	117117258(+)	`AAGAGG/AGTGTG`	2	--	ut3¹ ese³		2		NA	4
rs200983976^1,2	C	--	117117410(-)	`GGCTGG/TGAGAC`	2	--	ut3¹		0	--	--	--	--
rs144772515^1,2		--	117117493(+)	`GTTTTC/TCATAG`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IGSF3 (117117031 - 117210375 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 19 variations for IGSF3
15/18 CNVs (see all 18): 4243 30403 69617 74652 84485 6777 84487 74654 69618 74655 84484 31646 74656 74653 84488
1 Indel: 10996

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGSF3

DNA2.0 Custom Variant and Variant Library Synthesis for IGSF3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IGSF3 for disorders           About GeneDecksing

OMIM gene information: 603491    OMIM disorders: --

12 diseases for IGSF3:    About MalaCards

heparin-induced thrombocytopenia common variable immunodeficiency chronic fatigue syndrome velocardiofacial syndrome

digeorge syndrome periodontal disease burkitt's lymphoma thrombocytopenia

periodontitis osteomyelitis gingivitis immunodeficiency

1 Novoseek disease relationship for IGSF3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
periodontal diseases	44.4	1	7870466 (1)

Export disorders for IGSF3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IGSF3 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with IGSF3)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of a human cDNA IGSF3 encoding an immunoglobulin- like membrane protein: expression and mapping to chromosome band 1p13. (PubMed id 9790749)^{1, 2, 3} Saupe S.... De Sario A. (1998)
Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)^{1, 2} Seki N.... Ohara O. (1997)
EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. (PubMed id 11504738)^{2, 9} Stipp C.S.... Hemler M.E. (2001)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Shuffling of genes within low-copy repeats on 22q11 (LCR22) by Alu- mediated recombination events during evolution. (PubMed id 14656960)² Babcock M.... Morrow B.E. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)² Nakajima D.... Nagase T. (2002)
Spectrum of illness in pediatric common variable immunodeficiency. (PubMed id 17165275)⁹ Ogershok P.R....Wilson N.W. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3321	HGNC: 5950	AceView: IGSF3	Ensembl:ENSG00000143061	euGenes: HUgn3321
ECgene: IGSF3	H-InvDB: IGSF3

(According to HUGE)
About This Section

HUGE: KIAA0466

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IGSF3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IGSF3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IGSF3 gene:
Search GeneIP for patents involving IGSF3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	EMD Millipore Custom Antibody & Bulk Services
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	Antibodies for IGSF3 (IGSF3)		Browse Cell Culture Products
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	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for IGSF3		Browse OriGene shRNA RFPs
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGSF3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGSF3
	OriGene Protein Over-expression Lysate for IGSF3		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for IGSF3		OriGene 3'-UTR Clone for IGSF3
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGSF3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGSF3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for IGSF3		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for IGSF3		OriGene Custom Protein Services for IGSF3
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGSF3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGSF3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGSF3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGSF3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGSF3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGSF3

	GenScript Custom Purified and Recombinant Proteins Services for IGSF3		GenScript cDNA clones with any tag delivered in your preferred vector for IGSF3
	GenScript Custom Assay Services for IGSF3		GenScript Custom Superior Antibodies Services for IGSF3
	GenScript Custom overexpressing Cell Line Services for IGSF3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in IGSF3 promoter
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	RT² qPCR Primer Assay in human, mouse, rat IGSF3
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	SABiosciences Custom PCR Arrays for IGSF3

Search Tocris compounds for IGSF3

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for IGSF3
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	IGSF3 antibodies
	IGSF3 lysates

	Search for Antibodies for IGSF3 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for IGSF3
	Custom Antibody / Protein Production Service
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Browse ProSpec Recombinant Proteins

IGSF3 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for IGSF3

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGSF3

	SwitchGear 3'UTR luciferase reporter plasmids for IGSF3
	SwitchGear Promoter luciferase reporter plasmids for IGSF3

ThermoFisher Antibodies for IGSF3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGSF3

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes IGSF3 gene at Home site.

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IGSF3 Gene

immunoglobulin superfamily, member 3

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Export list of displayed genes

IGSF3 Gene

immunoglobulin superfamily, member 3

Aliasesfor IGSF3 gene

Summariesfor IGSF3 gene

Genomic Viewsfor IGSF3 gene

Proteinsfor IGSF3 gene

Protein Domains /Familiesfor IGSF3 gene

Functionfor IGSF3 gene

Pathways & Interactionsfor IGSF3 gene

Drugs & Compoundsfor IGSF3 gene

Transcriptsfor IGSF3 gene

Expression for IGSF3 gene

Orthologsfor IGSF3 gene

Paralogsfor IGSF3 gene

Genomic Variantsfor IGSF3 gene

Disorders / Diseasesfor IGSF3 gene

Publicationsfor IGSF3 gene

External Searches for IGSF3 gene

Genome Databases showing IGSF3 gene

Other Databases showing IGSF3 gene

Specialized Databases showing IGSF3 gene

Intellectual Propertyfor IGSF3 gene

Productsfor IGSF3 gene

View Random Gene

Aliases
for IGSF3 gene

Summaries
for IGSF3 gene

Genomic Views
for IGSF3 gene

Proteins
for IGSF3 gene

Protein Domains /
Families
for IGSF3 gene

Function
for IGSF3 gene

Pathways & Interactions
for IGSF3 gene

Drugs & Compounds
for IGSF3 gene

Transcripts
for IGSF3 gene

Expression
for IGSF3 gene

Orthologs
for IGSF3 gene

Paralogs
for IGSF3 gene

Genomic Variants
for IGSF3 gene

Disorders / Diseases
for IGSF3 gene

Publications
for IGSF3 gene

Intellectual Property
for IGSF3 gene

Products
for IGSF3 gene