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IGSF3 Gene

protein-coding   GIFtS: 55
GCID: GC01M117117

Immunoglobulin Superfamily, Member 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immunoglobulin Superfamily, Member 31 2     Immunoglobulin Superfamily Member 32
Glu-Trp-Ile EWI Motif-Containing Protein 32 3     EWI33
EWI-32 3     IgSF33
V82     KIAA04663
Immunoglobin Superfamily, Member 32     

External Ids:    HGNC: 59501   Entrez Gene: 33212   Ensembl: ENSG000001430617   OMIM: 6034915   UniProtKB: O750543   

Export aliases for IGSF3 gene to outside databases

Previous GC identifers: GC01M117619 GC01M115999 GC01M116264 GC01M116466 GC01M116829 GC01M116918 GC01M114976


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IGSF3 Gene:
IGSF3 (immunoglobulin superfamily, member 3) is a protein-coding gene. Diseases associated with IGSF3 include heparin-induced thrombocytopenia, and osteomyelitis. An important paralog of this gene is IGSF8.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IGSF3 gene promoter:
         HOXA9   HOXA9B   AML1a   Arnt   Meis-1b   PPAR-gamma1   PPAR-gamma2   Ik-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGSF3 promoter sequence
   Search Chromatin IP Primers for IGSF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGSF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13   Ensembl cytogenetic band:  1p13.1   HGNC cytogenetic band: 1p13

IGSF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGSF3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M117117:  view genomic region     (about GC identifiers)

Start:
117,117,031 bp from pter      End:
117,210,375 bp from pter
Size:
93,345 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IGSF3_HUMAN, O75054 (See protein sequence)
Recommended Name: Immunoglobulin superfamily member 3 precursor  
Size: 1194 amino acids; 135196 Da
Miscellaneous: Likely interchromosomal Alu-mediated fusion between IGSF3 on 1p13.1 and GGT on 22q11.2. Breakpoints
occurred inside Alu elements as well as in the 5' or 3' ends of them
Sequence caution: Sequence=AAC72013.1; Type=Frameshift; Positions=829, 861; Sequence=BAA32311.2; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: A6NJZ6 A6NMC7
Alternative splicing: 2 isoforms:  O75054-1   O75054-2   

Explore the universe of human proteins at neXtProt for IGSF3: NX_O75054

Explore proteomics data for IGSF3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn43, Asn418, Asn655, Asn842, Asn961, Asn1077
  • Modification sites at PhosphoSitePlus

  • See IGSF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001007238.1  NP_001533.2  

    ENSEMBL proteins: 
     ENSP00000358498   ENSP00000321184   ENSP00000474657   ENSP00000358495  

    IGSF3 Human Recombinant Protein Products:

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    Novus Biologicals IGSF3 Lysate
    Sino Biological Recombinant Protein for IGSF3
    Sino Biological Cell Lysate for IGSF3
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    Cloud-Clone Corp. Proteins for IGSF3

    IGSF3 Antibody Products:

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    Abcam antibodies for IGSF3
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    ThermoFisher Antibodies for IGSF3
    LSBio Antibodies in human, mouse, rat for IGSF3

    IGSF3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for IGSF3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IGSF3
    Cloud-Clone Corp. CLIAs for IGSF3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry O75054

    ProtoNet protein and cluster: O75054

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: IGSF3_HUMAN, O75054
    Similarity: Contains 8 Ig-like C2-type (immunoglobulin-like) domains


    IGSF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for IGSF3:
    immunoglobulin superfamily member 3,highly expressed in placenta,kidney and lung

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    IGSF3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IGSF3:
     Low eccentricity cells 

         1 MGI phenotypic allele for Igsf3 (no phenotypes)

    IGSF3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IGSF3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IGSF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IGSF3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IGSF3

    miRNA
    Products:
        
    miRTarBase miRNAs that target IGSF3:
    hsa-mir-769-5p (MIRT039143), hsa-let-7b-5p (MIRT032291), hsa-mir-378a-5p (MIRT043984), hsa-mir-103a-3p (MIRT027022), hsa-mir-1224-3p (MIRT036548), hsa-mir-26b-5p (MIRT029114), hsa-mir-7-5p (MIRT025690)

    Block miRNA regulation of human, mouse, rat IGSF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IGSF3 (see all 88):
    hsa-miR-140-5p hsa-miR-548j hsa-miR-576-3p hsa-miR-323-3p hsa-miR-193a-3p hsa-miR-640 hsa-miR-607 hsa-miR-376b
    SwitchGear 3'UTR luciferase reporter plasmidIGSF3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IGSF3
    Predesigned siRNA for gene silencing in human, mouse, rat IGSF3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IGSF3

    Clone
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    OriGene clones in human, mouse for IGSF3 (see all 11)
    OriGene ORF clones in mouse, rat for IGSF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IGSF3 (NM_001007237)
    Sino Biological Human cDNA Clone for IGSF3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGSF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGSF3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IGSF3
    Browse ESI BIO Cell Lines and PureStem Progenitors for IGSF3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGSF3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IGSF3_HUMAN, O75054: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    lysosome1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0016021integral component of membrane IEA--

    IGSF3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGSF3
    Interactions:

        Search GeneGlobe Interaction Network for IGSF3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for IGSF3 (ENSP000003211844) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD101ENSP000002566524STRING: ENSP00000256652
    PVRENSP000004020604STRING: ENSP00000402060
    --ENSP000004002554STRING: ENSP00000400255
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032808lacrimal gland development IMP--

    IGSF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGSF3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IGSF3 gene (2 alternative transcripts): 
    NM_001007237.2  NM_001542.3  

    Unigene Cluster for IGSF3:

    Immunoglobulin superfamily, member 3
    Hs.171057  [show with all ESTs]
    Unigene Representative Sequence: NM_001542
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369486(uc001egr.1) ENST00000318837(uc001egs.1) ENST00000481589
    ENST00000369483(uc001egq.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IGSF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IGSF3 (see all 88):
    hsa-miR-140-5p hsa-miR-548j hsa-miR-576-3p hsa-miR-323-3p hsa-miR-193a-3p hsa-miR-640 hsa-miR-607 hsa-miR-376b
    SwitchGear 3'UTR luciferase reporter plasmidIGSF3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IGSF3
    Predesigned siRNA for gene silencing in human, mouse, rat IGSF3
    Clone
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    OriGene clones in human, mouse for IGSF3 (see all 11)
    OriGene ORF clones in mouse, rat for IGSF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IGSF3 (NM_001007237)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGSF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGSF3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IGSF3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IGSF3
      QuantiTect SYBR Green Assays in human, mouse, rat IGSF3
      QuantiFast Probe-based Assays in human, mouse, rat IGSF3

    Additional mRNA sequence: 

    AB007935.2 AF031174.1 AK097809.1 BC071861.1 BC110651.1 BC130279.1 BC144132.1 

    5 DOTS entries:

    DT.455074  DT.95375731  DT.100780948  DT.95200793  DT.95375732 

    Selected AceView cDNA sequences (see all 227):

    CB305534 AI002566 AL699798 BM720675 AI039684 BF476477 BE276898 AB007935 
    AI161308 AA425437 BE891030 AW378564 AI633842 BF149247 T34388 AI818868 
    CA428090 AI202838 AA235015 BU688482 AA594800 BI492206 AL523806 AW236948 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGSF3 expression in normal human tissues (normalized intensities)      IGSF3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTAGAGAG
    IGSF3 Expression
    About this image


    IGSF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mandibular Condyle
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Neural Crest (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Brain (Nervous System)
    IGSF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGSF3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.171057

    UniProtKB/Swiss-Prot: IGSF3_HUMAN, O75054
    Tissue specificity: Expressed in a wide range of tissues with High expression in Placenta, kidney and lung

        Custom PCR Arrays for IGSF3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGSF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IGSF3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igsf31 , 5 immunoglobulin superfamily, member 31, 5 87.72(n)1
    92.63(a)1
      3 (44.30 cM)5
    789081  NM_207205.21  NP_997088.21 
     1013771255 
    chicken
    (Gallus gallus)
    Aves IGSF31 immunoglobulin superfamily, member 3 75.87(n)
    75.71(a)
      418451  XM_416662.4  XP_416662.3 
    lizard
    (Anolis carolinensis)
    Reptilia IGSF36
    immunoglobulin superfamily, member 3
    68(a)
    1 ↔ 1
    3(162474568-162574684)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.165922 Xenopus laevis transcribed sequence with weak similarity more 85.97(n)    CD361705.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-247j6.11 si:ch211-247j6.1 58.79(n)
    51.81(a)
      557878  NM_001159666.1  NP_001153138.1 


    ENSEMBL Gene Tree for IGSF3 (if available)
    TreeFam Gene Tree for IGSF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGSF3 gene
    IGSF82  CD1012  PTGFRN2  
    3 SIMAP similar genes for IGSF3 using alignment to 1 protein entry:     IGSF3_HUMAN:
    CD101    FLJ00271    IGSF8

    IGSF3 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for IGSF3
    PGOHUM00000246222 PGOHUM00000246259 PGOHUM00000240768


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IGSF3 (see all 2431)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1848734991,2
    --117116546(+) TCCCCA/GCTGCA 2 -- int10--------
    rs1892431051,2
    C--117116674(+) CCCCAA/CCCCCC 2 -- int10--------
    rs1816561571,2
    --117116681(+) CCCCAA/GCAAAA 2 -- int10--------
    rs1133731471,2
    F--117116807(+) TTACTG/ATATGT 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1857385531,2
    --117117029(+) CAGCCA/GTATTT 2 -- ut310--------
    rs1424247881,2
    C--117117062(+) TCTGAA/CGTGTA 2 -- ut310--------
    rs2015106581,2
    --117117110(+) CCTTT-/AAAAAA 2 -- ut310--------
    rs115534091,2
    C--117117258(+) AAGAGG/AGTGTG 2 -- ut31 ese32Minor allele frequency- A:0.00NA 4
    rs2009839761,2
    C--117117410(-) GGCTGG/TGAGAC 2 -- ut310--------
    rs1447725151,2
    --117117493(+) GTTTTC/TCATAG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for IGSF3 (117117031 - 117210375 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for IGSF3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv482103CNV Gain20164927
    nsv824309CNV Gain20364138
    nsv831148CNV Gain17160897
    nsv428190CNV Gain18775914
    esv32882CNV Gain17666407
    esv33190CNV Gain+Loss17666407
    esv28283CNV Gain+Loss19812545
    nsv10661CNV Gain+Loss18304495
    dgv89e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IGSF3
    DNA2.0 Custom Variant and Variant Library Synthesis for IGSF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603491    OMIM disorders: --

    10 diseases for IGSF3:    About MalaCards
    heparin-induced thrombocytopenia    osteomyelitis    periodontal disease    digeorge syndrome
    common variable immunodeficiency    thrombocytopenia    chronic fatigue syndrome    periodontitis
    burkitt's lymphoma    gingivitis


    IGSF3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for IGSF3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    periodontal diseases 44.4 1 7870466 (1)


    Export disorders for IGSF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGSF3 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with IGSF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a human cDNA IGSF3 encoding an immunoglobulin- like membrane protein: expression and mapping to chromosome band 1p13. (PubMed id 9790749)1, 2, 3 Saupe S.... De Sario A. (Genomics 1998)
    2. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (DNA Res. 1997)
    3. EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. (PubMed id 11504738)2, 9 Stipp C.S.... Hemler M.E. (J. Biol. Chem. 2001)
    4. Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations. (PubMed id 23829686)1 Ding L....Mersha T.B. (Hum. Genomics 2013)
    5. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Shuffling of genes within low-copy repeats on 22q11 (LCR22) by Alu- mediated recombination events during evolution. (PubMed id 14656960)2 Babcock M.... Morrow B.E. (Genome Res. 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3321 HGNC: 5950 AceView: IGSF3 Ensembl:ENSG00000143061 euGenes: HUgn3321
    ECgene: IGSF3 H-InvDB: IGSF3

    (According to HUGE)
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    HUGE: KIAA0466

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IGSF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IGSF3 gene:
    Search GeneIP for patents involving IGSF3

    GeneCards and IP:
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