Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IGSF23 Gene

Aliases for IGSF23 Gene

  • Immunoglobulin Superfamily Member 23 2 3 5
  • Immunoglobulin Superfamily, Member 23 2

External Ids for IGSF23 Gene

Previous GeneCards Identifiers for IGSF23 Gene

  • GC19P045117

Summaries for IGSF23 Gene

Entrez Gene Summary for IGSF23 Gene

  • This gene encodes a protein that has one immunoglobulin (Ig) domain and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Nov 2011]

GeneCards Summary for IGSF23 Gene

IGSF23 (Immunoglobulin Superfamily Member 23) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGSF23 Gene

Genomics for IGSF23 Gene

Regulatory Elements for IGSF23 Gene

Enhancers for IGSF23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F044923 1.4 FANTOM5 ENCODE 8 +312.4 312355 4.1 HDGF ARNT MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF225 ZNF180 ZNF45 ZNF155 ZNF284 ZNF224 ZNF223 QPCTL ZNF234 MRPS15P2
GH19F044720 1.7 FANTOM5 Ensembl ENCODE 3.3 +110.0 109955 6.3 ARID4B SIN3A DMAP1 ZNF48 YY1 GATA2 ZNF143 ZNF207 FOS ZNF263 ENSG00000266903 APOE RELB APOC2 CEACAM19 BCL3 CLASRP CEACAM16 IGSF23 APOC4
GH19F044727 0.9 FANTOM5 Ensembl 2.8 +114.7 114695 1.0 BCOR IKZF1 ZMYM3 PRDM10 ZNF16 KDM1A IGSF23 CLASRP APOC2 ENSG00000252200 GC19M044726 LOC105372416
GH19F044610 1.3 Ensembl ENCODE 0.8 0.0 -4 5.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF143 SP5 PPARG CEACAM22P PVR CEACAM19 IGSF23 ENSG00000224366
GH19F044586 1.8 FANTOM5 Ensembl ENCODE 0.3 -23.4 -23401 8.1 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 TBX21 ZNF180 ZNF45 ZNF234 ZNF155 ZNF284 ZNF225 NECTIN2 EXOC3L2 LOC105372418 ENSG00000267614
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IGSF23 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGSF23 Gene

44,613,590 bp from pter
44,636,781 bp from pter
23,192 bases
Plus strand

Genomic View for IGSF23 Gene

Genes around IGSF23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGSF23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGSF23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGSF23 Gene

Proteins for IGSF23 Gene

  • Protein details for IGSF23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin superfamily member 23
    Protein Accession:

    Protein attributes for IGSF23 Gene

    192 amino acids
    Molecular mass:
    20591 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGSF23 Gene

Post-translational modifications for IGSF23 Gene

No data available for DME Specific Peptides for IGSF23 Gene

Domains & Families for IGSF23 Gene

Gene Families for IGSF23 Gene

Protein Domains for IGSF23 Gene


Suggested Antigen Peptide Sequences for IGSF23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGSF23: view

Function for IGSF23 Gene

Phenotypes for IGSF23 Gene

GenomeRNAi human phenotypes for IGSF23:
genes like me logo Genes that share phenotypes with IGSF23: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGSF23 Gene

Localization for IGSF23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGSF23 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGSF23 gene
Compartment Confidence
plasma membrane 3
mitochondrion 3
nucleus 2
extracellular 1
cytoskeleton 1
peroxisome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IGSF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IGSF23: view

Pathways & Interactions for IGSF23 Gene

SuperPathways for IGSF23 Gene

No Data Available

Interacting Proteins for IGSF23 Gene

Gene Ontology (GO) - Biological Process for IGSF23 Gene


No data available for Pathways by source and SIGNOR curated interactions for IGSF23 Gene

Transcripts for IGSF23 Gene

mRNA/cDNA for IGSF23 Gene

(11) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGSF23 Gene

Immunoglobulin superfamily, member 23:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGSF23 Gene

No ASD Table

Relevant External Links for IGSF23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGSF23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGSF23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGSF23 Gene

This gene is overexpressed in Liver (x31.9) and Small Intestine - Terminal Ileum (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of IGSF23 Gene:


SOURCE GeneReport for Unigene cluster for IGSF23 Gene:

genes like me logo Genes that share expression patterns with IGSF23: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for IGSF23 Gene

Orthologs for IGSF23 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGSF23 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IGSF23 34 35
  • 98.26 (n)
(Canis familiaris)
Mammalia IGSF23 34 35
  • 70.6 (n)
(Mus musculus)
Mammalia Igsf23 34 16 35
  • 67.63 (n)
(Bos Taurus)
Mammalia IGSF23 34 35
  • 67.16 (n)
(Rattus norvegicus)
Mammalia Igsf23 34
  • 66.91 (n)
Species where no ortholog for IGSF23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGSF23 Gene

Gene Tree for IGSF23 (if available)
Gene Tree for IGSF23 (if available)

Paralogs for IGSF23 Gene

No data available for Paralogs for IGSF23 Gene

Variants for IGSF23 Gene

Sequence variations from dbSNP and Humsavar for IGSF23 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401218 -- 44,632,159(+) gggca(A/G)tatgc intron-variant, downstream-variant-500B
rs10412507 -- 44,618,113(+) TTCTC(A/G)GAGCT intron-variant, splice-acceptor-variant, utr-variant-5-prime
rs10414111 -- 44,620,053(+) atcac(A/G/T)agttc intron-variant
rs10460181 -- 44,636,865(+) TTTGC(A/G)CTGTT intron-variant, downstream-variant-500B
rs1047105 -- 44,636,631(+) AGAGG(C/T)TCATC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IGSF23 Gene

Variant ID Type Subtype PubMed ID
nsv483005 CNV loss 15286789
nsv1062812 CNV gain 25217958

Relevant External Links for IGSF23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for IGSF23 Gene

Disorders for IGSF23 Gene

Relevant External Links for IGSF23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IGSF23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGSF23 Gene

Publications for IGSF23 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  4. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington J.J. … Ducar M. (Nat. Biotechnol. 2001) 3 64

Products for IGSF23 Gene

Sources for IGSF23 Gene

Loading form....