IGSF22 Gene
protein-coding GIFtS: 41
GCID: GC11M018683
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|
immunoglobulin superfamily, member 22
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Aliases
for IGSF22 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Immunoglobulin Superfamily, Member 221 2 | | FLJ377941 | | Immunoglobulin Superfamily Member 222 | | IgSF223 |
Export aliases for IGSF22 gene to outside databasesPrevious GC identifer: GC11M018410 |
Summaries
for IGSF22 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for IGSF22 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IGSF22 gene promoter:
Max1 TBP Egr-1 HTF MyoD Lmo2 Evi-1 AREB6 MZF-1 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for IGSF22
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGSF22 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.1 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p15.1IGSF22 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M018683: view genomic region
(about GC identifiers)
Start:
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18,725,852 bp from pter |
End:
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18,747,777 bp from pter |
Size:
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21,926 bases |
Orientation:
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minus strand |
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Proteins
for IGSF22 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IGS22_HUMAN, Q8N9C0 (See
protein sequence)Recommended Name: Immunoglobulin superfamily member 22 Size: 903 amino acids; 100400 Da
Secondary accessions: A6NNA0Explore the universe of human proteins at neXtProt for IGSF22: NX_Q8N9C0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N9C0
IGSF22 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775859.3
ENSEMBL proteins: ENSP00000421191 ENSP00000322422
Human Recombinant Protein Products for IGSF22:
IGSF22 Antibody Products:
Assay Products for IGSF22: |
Protein
Domains /
Families
for IGSF22 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IGSF22 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N9C0ProtoNet protein and cluster: Q8N9C0 UniProtKB/Swiss-Prot: IGS22_HUMAN, Q8N9C0Similarity: Contains 2 fibronectin type-III domainsSimilarity: Contains 4 Ig-like (immunoglobulin-like) domains |
Function
for IGSF22 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGSF22 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGSF22 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IGSF22 (NM_173588) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IGSF22 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGSF22 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGSF22 |
|
Pathways & Interactions
for IGSF22 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGSF22
1 Interacting protein for IGSF22 (Q8N9C02) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for IGSF22 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IGSF22
Search CenterWatch for drugs/clinical trials and news about IGSF22 / IGS22
|
Transcripts
for IGSF22 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IGSF22 gene: NM_173588.3 Unigene Cluster for IGSF22: Immunoglobulin superfamily, member 22 Hs.434152 [show with all ESTs]Unigene Representative Sequence: NM_1735885 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000513874(uc009yht.2) ENST00000319338(uc001mpa.2) ENST00000510673
ENST00000504981 ENST00000412229
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGSF22 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGSF22 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IGSF22 (NM_173588) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IGSF22 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGSF22 |
Additional cDNA sequence: BC115396.1 BC115397.1 4 DOTS entries: DT.95364749 DT.97798566 DT.402934 DT.91885563 15 AceView cDNA sequences: AI373612 AI522227 AA255875 BI909151 BX499613 AI241151 AK095113 NM_173588 BU729524 AI471787 BM715320 AI075240 AA261925 AI952274 AW975293
GeneLoc Exon Structure
|
Expression
for IGSF22 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IGSF22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCAGTGTA
About this image
See IGSF22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGSF22
SOURCE GeneReport for Unigene cluster: Hs.434152
SABiosciences Custom PCR Arrays for IGSF22
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGSF22
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat IGSF22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGSF22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGSF22 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGSF22 |
Orthologs
for IGSF22 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for IGSF22 gene from 2/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
IGSF226 |
-- |
74(a) |
1 ↔ 1 |
1(67988391-68021478) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG149646 |
-- |
7(a) |
1 → many |
3L(3172817-3178580) |
ENSEMBL Gene Tree for IGSF22 (if available)
TreeFam Gene Tree for IGSF22 (if available) |
Paralogs
for IGSF22 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IGSF22 gene
- MYOM12 MYBPH2 IGFN12 MYBPC22 MYBPC12 MYBPC32 MYBPHL2 MYOM32
- MYOM22
4 SIMAP similar genes for IGSF22 using alignment to 2 protein entries: IGS22_HUMAN (see all proteins):MUSK IGFN1 TTN MYBPH
IGSF22 for paralogs About GeneDecksing
|
Genomic Variants
for IGSF22 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IGSF22 (18725852 - 18747777 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for IGSF22
1 CNV: 71293
1 Indel: 71292 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGSF22 |
|
Disorders
/ Diseases
for IGSF22 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IGSF22 for disorders About GeneDecksing
2  diseases for IGSF22: About MalaCardsrheumatoid arthritis arthritis
Export disorders for IGSF22 gene to outside databases
|
Publications
for IGSF22 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IGSF22 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IGSF22) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Screening disease-associated proteins from sera of pa tients with rheumatoid arthritis: a comparative proteomic study. (PubMed id 20367977)9 Li T.W....Gu J.R. (2010)
- Serum disease-associated proteins of ankylosing spond ylitis: results of a preliminary study by comparative proteomics. (PubMed id 20483041)9 Li T....Gu J. (2010)
- The invariant system of coordinates of antibody molec ules: prediction of the 'standard' C alpha framework of VL and VH dom ains. (PubMed id 8622995)9 Gelfand I.M....Leshchiner D. (1996)
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External Searches for IGSF22 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing IGSF22 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IGSF22 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IGSF22 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IGSF22 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IGSF22 gene:
Search GeneIP for patents involving IGSF22
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IGSF22 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGSF22 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IGSF22 | | OriGene 3'-UTR Clone for IGSF22 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGSF22 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGSF22 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGSF22 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGSF22 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGSF22 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGSF22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGSF22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGSF22 |
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 |  |  |  | |
| | | | Search Tocris compounds for IGSF22 |
| |  |  |  |  | | | | |
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 | | | IGSF22 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGSF22 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for IGSF22 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGSF22 |
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