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Aliases for IGSF22 Gene

Aliases for IGSF22 Gene

  • Immunoglobulin Superfamily Member 22 2 3 5
  • Immunoglobulin Superfamily, Member 22 2
  • IgSF22 4
  • IGFN2 3

External Ids for IGSF22 Gene

Previous GeneCards Identifiers for IGSF22 Gene

  • GC11M018410

Summaries for IGSF22 Gene

GeneCards Summary for IGSF22 Gene

IGSF22 (Immunoglobulin Superfamily Member 22) is a Protein Coding gene. An important paralog of this gene is IGFN1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGSF22 Gene

Genomics for IGSF22 Gene

Regulatory Elements for IGSF22 Gene

Enhancers for IGSF22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around IGSF22 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGSF22 Gene

18,704,305 bp from pter
18,726,230 bp from pter
21,926 bases
Minus strand

Genomic View for IGSF22 Gene

Genes around IGSF22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGSF22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGSF22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGSF22 Gene

Proteins for IGSF22 Gene

  • Protein details for IGSF22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin superfamily member 22
    Protein Accession:
    Secondary Accessions:
    • A6NNA0
    • D6RGV7

    Protein attributes for IGSF22 Gene

    903 amino acids
    Molecular mass:
    100400 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IGSF22 Gene


neXtProt entry for IGSF22 Gene

Post-translational modifications for IGSF22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGSF22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGSF22 Gene

Domains & Families for IGSF22 Gene

Protein Domains for IGSF22 Gene

Suggested Antigen Peptide Sequences for IGSF22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 fibronectin type-III domains.
  • Contains 2 fibronectin type-III domains.
  • Contains 4 Ig-like (immunoglobulin-like) domains.
genes like me logo Genes that share domains with IGSF22: view

Function for IGSF22 Gene

Phenotypes for IGSF22 Gene

genes like me logo Genes that share phenotypes with IGSF22: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGSF22 Gene

Localization for IGSF22 Gene

Subcellular locations from

Jensen Localization Image for IGSF22 Gene COMPARTMENTS Subcellular localization image for IGSF22 gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IGSF22 Gene

Pathways & Interactions for IGSF22 Gene

SuperPathways for IGSF22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGSF22 Gene


No data available for Pathways by source and SIGNOR curated interactions for IGSF22 Gene

Drugs & Compounds for IGSF22 Gene

No Compound Related Data Available

Transcripts for IGSF22 Gene

mRNA/cDNA for IGSF22 Gene

Unigene Clusters for IGSF22 Gene

Immunoglobulin superfamily, member 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGSF22 Gene

No ASD Table

Relevant External Links for IGSF22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGSF22 Gene

mRNA expression in normal human tissues for IGSF22 Gene

Protein differential expression in normal tissues from HIPED for IGSF22 Gene

This gene is overexpressed in Serum (59.4) and Plasma (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGSF22 Gene

Protein tissue co-expression partners for IGSF22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGSF22 Gene:


SOURCE GeneReport for Unigene cluster for IGSF22 Gene:

genes like me logo Genes that share expression patterns with IGSF22: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IGSF22 Gene

Orthologs for IGSF22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGSF22 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia IGSF22 34
  • 90.16 (n)
  • 91.54 (a)
IGSF22 35
  • 92 (a)
(Monodelphis domestica)
Mammalia IGSF22 35
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 24 (a)
(Pan troglodytes)
Mammalia IGSF22 35
  • 99 (a)
(Anolis carolinensis)
Reptilia IGSF22 35
  • 74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
Species where no ortholog for IGSF22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGSF22 Gene

Gene Tree for IGSF22 (if available)
Gene Tree for IGSF22 (if available)

Paralogs for IGSF22 Gene

Paralogs for IGSF22 Gene

(2) SIMAP similar genes for IGSF22 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IGSF22: view

Variants for IGSF22 Gene

Sequence variations from dbSNP and Humsavar for IGSF22 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10832975 - 18,721,633(+) TTTGG(C/G)GTTCC reference, missense
rs3740710 - 18,720,275(-) GCCAC(G/T)GACTT reference, missense
rs10766494 - 18,716,734(+) GTCAA(C/T)AGTGA reference, missense
rs4424652 - 18,715,548(+) CTGCT(C/T)GCTTG reference, missense
rs3887899 - 18,715,455(-) CTACA(A/G/T)TACTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IGSF22 Gene

Variant ID Type Subtype PubMed ID
esv25440 CNV loss 19812545
nsv1047371 CNV gain 25217958
nsv525192 CNV loss 19592680
nsv525452 CNV gain 19592680
nsv553633 CNV gain 21841781
nsv825774 CNV loss 20364138

Variation tolerance for IGSF22 Gene

Residual Variation Intolerance Score: 98.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.86; 98.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGSF22 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGSF22 Gene

Disorders for IGSF22 Gene

Relevant External Links for IGSF22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IGSF22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGSF22 Gene

Publications for IGSF22 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I. … Futreal P.A. (Nature 2011) 4 65
  3. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3 65
  4. Screening disease-associated proteins from sera of patients with rheumatoid arthritis: a comparative proteomic study. (PMID: 20367977) Li T.W. … Gu J.R. (Chin. Med. J. 2010) 22 65
  5. Serum disease-associated proteins of ankylosing spondylitis: results of a preliminary study by comparative proteomics. (PMID: 20483041) Li T. … Gu J. (Clin. Exp. Rheumatol. 2010) 22 65

Products for IGSF22 Gene

Sources for IGSF22 Gene

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