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Aliases for IGSF22 Gene

Aliases for IGSF22 Gene

  • Immunoglobulin Superfamily, Member 22 2 3
  • Immunoglobulin Superfamily Member 22 3
  • IgSF22 4
  • IGFN2 3

External Ids for IGSF22 Gene

Summaries for IGSF22 Gene

GeneCards Summary for IGSF22 Gene

IGSF22 (Immunoglobulin Superfamily, Member 22) is a Protein Coding gene. An important paralog of this gene is MYBPC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGSF22 Gene

Genomics for IGSF22 Gene

Genomic Location for IGSF22 Gene

Start:
18,704,305 bp from pter
End:
18,726,230 bp from pter
Size:
21,926 bases
Orientation:
Minus strand

Genomic View for IGSF22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGSF22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGSF22 Gene

Regulatory Elements for IGSF22 Gene

Proteins for IGSF22 Gene

  • Protein details for IGSF22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9C0-IGS22_HUMAN
    Recommended name:
    Immunoglobulin superfamily member 22
    Protein Accession:
    Q8N9C0
    Secondary Accessions:
    • A6NNA0
    • D6RGV7

    Protein attributes for IGSF22 Gene

    Size:
    903 amino acids
    Molecular mass:
    100400 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IGSF22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGSF22 Gene

Proteomics data for IGSF22 Gene at MOPED

Post-translational modifications for IGSF22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGSF22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGSF22 Gene

Domains for IGSF22 Gene

Gene Families for IGSF22 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • FN3 :Fibronectin type III domain containing

Protein Domains for IGSF22 Gene

UniProtKB/Swiss-Prot:

IGS22_HUMAN
Domain:
  • Contains 2 fibronectin type-III domains.:
    • Q8N9C0
  • Contains 4 Ig-like (immunoglobulin-like) domains.:
    • Q8N9C0
genes like me logo Genes that share domains with IGSF22: view

Function for IGSF22 Gene

Gene Ontology (GO) - Molecular Function for IGSF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IGSF22: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IGSF22 Gene

Localization for IGSF22 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGSF22 Gene COMPARTMENTS Subcellular localization image for IGSF22 gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for IGSF22 Gene

Pathways for IGSF22 Gene

SuperPathways for IGSF22 Gene

No Data Available

Interacting Proteins for IGSF22 Gene

Gene Ontology (GO) - Biological Process for IGSF22 Gene

None

No data available for Pathways by source for IGSF22 Gene

Transcripts for IGSF22 Gene

mRNA/cDNA for IGSF22 Gene

Unigene Clusters for IGSF22 Gene

Immunoglobulin superfamily, member 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGSF22 Gene

No ASD Table

Relevant External Links for IGSF22 Gene

GeneLoc Exon Structure for
IGSF22
ECgene alternative splicing isoforms for
IGSF22

Expression for IGSF22 Gene

mRNA expression in normal human tissues for IGSF22 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IGSF22 Gene

SOURCE GeneReport for Unigene cluster for IGSF22 Gene Hs.434152

genes like me logo Genes that share expressions with IGSF22: view

Orthologs for IGSF22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGSF22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGSF22 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGSF22 36
  • 90.16 (n)
  • 91.54 (a)
IGSF22 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGSF22 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia IGSF22 37
  • 74 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 25 (a)
ManyToMany
Species with no ortholog for IGSF22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGSF22 Gene

ENSEMBL:
Gene Tree for IGSF22 (if available)
TreeFam:
Gene Tree for IGSF22 (if available)

Paralogs for IGSF22 Gene

Paralogs for IGSF22 Gene

Selected SIMAP similar genes for IGSF22 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IGSF22: view

Variants for IGSF22 Gene

Sequence variations from dbSNP and Humsavar for IGSF22 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs748943 -- 18,726,456(+) TGGGT(A/G)GGACC upstream-variant-2KB
rs748944 -- 18,726,499(+) TGCAC(A/G)GGCAC upstream-variant-2KB
rs748945 -- 18,726,692(+) AGTAT(C/G)TTTAC upstream-variant-2KB
rs873670 -- 18,727,272(-) ACAAG(A/G)TGCCA upstream-variant-2KB
rs1054771 -- 18,705,433(+) TTTTT(A/T)TTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGSF22 Gene

Variant ID Type Subtype PubMed ID
nsv897028 CNV Loss 21882294
nsv525192 CNV Loss 19592680
esv25440 CNV Loss 19812545
nsv525452 CNV Gain 19592680
nsv825774 CNV Loss 20364138

Relevant External Links for IGSF22 Gene

HapMap Linkage Disequilibrium report
IGSF22
Human Gene Mutation Database (HGMD)
IGSF22

Disorders for IGSF22 Gene

No disorders were found for IGSF22 Gene.

No data available for UniProtKB/Swiss-Prot for IGSF22 Gene

Publications for IGSF22 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 3
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4
  5. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I. … Futreal P.A. (Nature 2011) 4

Products for IGSF22 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate IGSF22
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IGSF22
    • Block miRNA regulation of IGSF22 using miScript Target Protectors

    Sources for IGSF22 Gene

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