IGSF21 Gene
protein-coding GIFtS : 48
GCID: GC01 P018434
immunoglobin superfamily, member 21
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Aliasesfor IGSF21 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Immunoglobin Superfamily, Member 21 1 2 MGC157301 RP11-121A23.11 Immunoglobulin Superfamily Member 212 IgSF213
Export aliases for IGSF21 gene to outside databases Previous GC identifers: GC01P018180 GC01P018306 GC01P016680
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Summariesfor IGSF21 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for IGSF21 : This gene encodes a protein which has two immunoglobulin (Ig) domains and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. (provided by RefSeq, Sep 2011)
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Genomic Viewsfor IGSF21 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_004610.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the IGSF21 gene promoter: Sp1 MyoD IRF-1 Tal-1beta AP-2gamma E47 POU2F1 POU2F1a FOXO1a FOXO1 Other transcription factors Search SABiosciences Chromatin IP Primers for IGSF21 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat IGSF21
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13 IGSF21 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P018434: view genomic region
(about GC identifiers )
Start:
18,434,240 bp from pter
End:
18,704,979 bp from pter
Size:
270,740 bases
Orientation:
plus strand
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Proteinsfor IGSF21 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: IGS21_HUMAN, Q96ID5 (See
protein sequence )Recommended Name: Immunoglobulin superfamily member 21 precursor Size : 467 amino acids; 51835 Da
Subcellular location : Secreted (Potential)
Secondary accessions : Q8NBR8Explore the universe of human proteins at neXtProt for IGSF21: NX_Q96ID5 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96ID5 IGSF21 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_116269.3 ENSEMBL proteins: ENSP00000251296 ENSP00000388681 Human Recombinant Protein Products for IGSF21: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
IEA --
IGSF21 for ontologies About GeneDecksing IGSF21 Antibody Products: Assay Products for IGSF21:
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Protein
Domains / Familiesfor IGSF21 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
IGSF21 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q96ID5 ProtoNet protein and cluster: Q96ID5
1 Blocks protein family : IPB003599 Immunoglobulin subtype UniProtKB/Swiss-Prot: IGS21_HUMAN, Q96ID5 Similarity : Contains 2 Ig-like (immunoglobulin-like) domains
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Functionfor IGSF21 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Phenotypes: 1 GenomeRNAi human phenotype for IGSF21 :Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IGSF21 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IGSF21OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: IGSF21 (NM_032880 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IGSF21 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IGSF21
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGSF21
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Pathways & Interactionsfor IGSF21 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IGSF21 STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)5/46 Interacting proteins for IGSF21 (Q96ID5 2 , 3 ENSP00000251296 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 46 )About this table
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Drugs & Compoundsfor IGSF21 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for IGSF21 Search CenterWatch for drugs/clinical trials and news about IGSF21 / IGS21
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Transcriptsfor IGSF21 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for IGSF21 gene: NM_032880.4 Unigene Cluster for IGSF21:
Immunoglobin superfamily, member 21 Hs.212511 [show with all ESTs ] Unigene Representative Sequence: NM_032880 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000251296 (uc001bau.2 ) ENST00000412684 ENST00000497331 (uc001bav.2 )ENST00000473951 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IGSF21 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IGSF21OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: IGSF21 (NM_032880 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IGSF21 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IGSF21
Additional cDNA sequence: AK075316.1 AK294121.1 BC007618.1
4 DOTS entries : DT.215471 DT.101977213
DT.91902680 DT.95176500 24/98 AceView cDNA sequences (see all 98 ):
BU727314 BQ068297 AK092618 BM710418 T33909 R52319 AX747631 D51740 BF346623 AA363868 BC007618 BI758183 F04956 CR593587 CR610302 D51951 BE674731 AL536512 AW157772 AI681322 AI589300 H49512 AL565578 BG818356 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for IGSF21 (see all 6 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 SP1 :     -         -   -       -   -             SP2 :                     -   -             SP3 :             -   -                     SP4 :                                   SP5 :                                  
ECgene alternative splicing isoforms for IGSF21
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Expression for IGSF21 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section IGSF21 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TATCGCTGCAAbout this image IGSF21 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See IGSF21 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for IGSF21 SOURCE GeneReport for Unigene cluster: Hs.212511 SABiosciences Custom PCR Arrays for IGSF21 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for IGSF21Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat IGSF21 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat IGSF21 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat IGSF21 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGSF21
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Orthologsfor IGSF21 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for IGSF21 gene from 4/9 species (see all 9 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Igsf211 , 5
immunoglobin superfamily, member 215 immunoglobulin superfamily, member 211
87.72(n) 1 94.43(a) 1
 
4 (71.09 cM) 5 230868 1 NM_198610.2 1 NP_941012.1 1 140026846 5
chicken (Gallus gallus)
Aves
IGSF211
immunoglobin superfamily, member 21
76.88(n) 84.23(a)
 
419359 XM_417520.3 XP_417520.3
lizard (Anolis carolinensis)
Reptilia
IGSF216
--
78(a)
1 ↔ 1
GL344239.1(40530-66449)
zebrafish (Danio rerio)
Actinopterygii
BI428490.12
--
76.26(n)
 
BI428490.1
ENSEMBL Gene Tree for IGSF21 (if available)TreeFam Gene Tree for IGSF21 (if available)
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Paralogsfor IGSF21 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for IGSF21 gene
IGSF21 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for IGSF21 PGOHUM00000242833
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Genomic Variantsfor IGSF21 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for IGSF21 (18434240 - 18684240 bp, first 250kb of IGSF21)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for IGSF21 1 CNV : 4213 2 Indels : 74394 84107
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing IGSF21
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Disorders
/ Diseasesfor IGSF21 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
IGSF21 for disorders About GeneDecksing 2 diseases for IGSF21 : About MalaCards prostate cancer prostatitis Human Genome Epidemiology (HuGE) Navigator: IGSF21 (2 documents) Export disorders for IGSF21 gene to outside databases
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Publicationsfor IGSF21 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for IGSF21 gene, integrated from 9 sources (see all 12 ): (articles sorted by number of sources associating them with IGSF21) Utopia : connect your pdf to the dynamic world of online information
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743) 1 , 2 Otsuki T....Isogai T. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Genome-wide meta-analysis for severe diabetic retinop athy. (PubMed id 21441570) 1 Grassi M.A....Nicolae D.L. (2011) A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206) 1 Vinayagam A....Wanker E.E. (2011) Genome-wide association study to identify single nucl eotide polymorphisms (SNPs) associated with the development of erectile dysfunc tion in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654) 1 Kerns S.L....Rosenstein B.S. (2010) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061) 1 Trynka G....Wijmenga C. (2009) The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974) 2 Sjoeblom T.... Velculescu V.E. (2006)
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External Searches for IGSF21 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing IGSF21 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing IGSF21 gene
(According to HUGE )
About This Section --
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Specialized Databases showing IGSF21 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for IGSF21 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for IGSF21 gene: Search GeneIP for patents involving IGSF21 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor IGSF21 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for IGSF21 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for IGSF21 OriGene Protein Over-expression Lysate for IGSF21 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for IGSF21 OriGene 3'-UTR Clone for IGSF21 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for IGSF21 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for IGSF21 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for IGSF21 OriGene Custom Protein Services for IGSF21 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGSF21 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing IGSF21 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat IGSF21 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat IGSF21 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat IGSF21 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat IGSF21
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IGSF21 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGSF21
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat IGSF21
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Aliases for IGSF21
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Disorders / Diseases for IGSF21
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Expression for IGSF21
Function for IGSF21
Genomic Views for IGSF21
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Pathways / Interactions for IGSF21
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