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Aliases for IGSF21 Gene

Aliases for IGSF21 Gene

  • Immunoglobin Superfamily Member 21 2 3 5
  • Immunoglobin Superfamily, Member 21 2
  • IgSF21 4

External Ids for IGSF21 Gene

Previous GeneCards Identifiers for IGSF21 Gene

  • GC01P018180
  • GC01P018306
  • GC01P018434
  • GC01P016680

Summaries for IGSF21 Gene

Entrez Gene Summary for IGSF21 Gene

  • This gene encodes a protein which has two immunoglobulin (Ig) domains and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Sep 2011]

GeneCards Summary for IGSF21 Gene

IGSF21 (Immunoglobin Superfamily Member 21) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGSF21 Gene

Genomics for IGSF21 Gene

Regulatory Elements for IGSF21 Gene

Enhancers for IGSF21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F017635 1.4 FANTOM5 Ensembl ENCODE 11 -472.1 -472064 1.4 ZFHX2 IKZF1 TBX21 SPI1 EGR2 IGSF21 ARHGEF10L PADI4 ACTL8 GC01P017551
GH01F018262 0.2 ENCODE 10.4 +155.2 155156 0.2 IGSF21 PIR34886 GC01P018288 LOC105376814
GH01F018256 0.2 ENCODE 10.2 +148.7 148736 0.2 ELF3 ZNF792 ZMYM3 ZNF48 ZSCAN9 ZIC2 HBP1 RARA ZBTB48 ZNF143 IGSF21 GC01P018288 PIR34886 LOC105376814
GH01F018122 0.5 FANTOM5 3.8 +14.6 14611 0.4 LOC105376814 IGSF21 ENSG00000280222 GC01M018090
GH01F018107 0.2 ENCODE 0.8 -0.1 -105 0.2 KLF1 MAZ SP3 SP2 KLF17 PATZ1 WT1 EZH2 ZBTB20 IGSF21 LINC01654
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IGSF21 on UCSC Golden Path with GeneCards custom track

Promoters for IGSF21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001742185 154 601 CTCF KLF1 MAZ SP3 SP2 KLF17 PATZ1 ZNF341 ZBTB26 WT1

Genomic Location for IGSF21 Gene

18,107,746 bp from pter
18,378,484 bp from pter
270,739 bases
Plus strand

Genomic View for IGSF21 Gene

Genes around IGSF21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGSF21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGSF21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGSF21 Gene

Proteins for IGSF21 Gene

  • Protein details for IGSF21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin superfamily member 21
    Protein Accession:
    Secondary Accessions:
    • Q8NBR8

    Protein attributes for IGSF21 Gene

    467 amino acids
    Molecular mass:
    51835 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGSF21 Gene

Post-translational modifications for IGSF21 Gene

  • Glycosylation at Asn 82, Asn 165, Asn 407, and Asn 444
  • Modification sites at PhosphoSitePlus

Other Protein References for IGSF21 Gene

No data available for DME Specific Peptides for IGSF21 Gene

Domains & Families for IGSF21 Gene

Protein Domains for IGSF21 Gene

Suggested Antigen Peptide Sequences for IGSF21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 Ig-like (immunoglobulin-like) domains.
  • Contains 2 Ig-like (immunoglobulin-like) domains.
genes like me logo Genes that share domains with IGSF21: view

Function for IGSF21 Gene

genes like me logo Genes that share phenotypes with IGSF21: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IGSF21

miRNA for IGSF21 Gene

miRTarBase miRNAs that target IGSF21

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGSF21 Gene

Localization for IGSF21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGSF21 Gene


Subcellular locations from

Jensen Localization Image for IGSF21 Gene COMPARTMENTS Subcellular localization image for IGSF21 gene
Compartment Confidence
extracellular 4
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for IGSF21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with IGSF21: view

Pathways & Interactions for IGSF21 Gene

SuperPathways for IGSF21 Gene

No Data Available

Interacting Proteins for IGSF21 Gene

Gene Ontology (GO) - Biological Process for IGSF21 Gene


No data available for Pathways by source and SIGNOR curated interactions for IGSF21 Gene

Transcripts for IGSF21 Gene

Unigene Clusters for IGSF21 Gene

Immunoglobin superfamily, member 21:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGSF21 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12
SP1: - - - - -
SP2: - -
SP3: - -

Relevant External Links for IGSF21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGSF21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGSF21 Gene

mRNA differential expression in normal tissues according to GTEx for IGSF21 Gene

This gene is overexpressed in Brain - Cerebellum (x8.2), Brain - Cerebellar Hemisphere (x7.4), Brain - Cortex (x6.2), Brain - Frontal Cortex (BA9) (x5.0), and Brain - Anterior cingulate cortex (BA24) (x4.7).

Protein differential expression in normal tissues from HIPED for IGSF21 Gene

This gene is overexpressed in Frontal cortex (30.6) and Fetal Brain (25.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGSF21 Gene

Protein tissue co-expression partners for IGSF21 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGSF21 Gene:


SOURCE GeneReport for Unigene cluster for IGSF21 Gene:

genes like me logo Genes that share expression patterns with IGSF21: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for IGSF21 Gene

Orthologs for IGSF21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGSF21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IGSF21 34 35
  • 99.43 (n)
(Canis familiaris)
Mammalia IGSF21 34 35
  • 91.15 (n)
(Bos Taurus)
Mammalia IGSF21 34 35
  • 88.55 (n)
(Rattus norvegicus)
Mammalia Igsf21 34
  • 87.87 (n)
(Mus musculus)
Mammalia Igsf21 34 16 35
  • 87.72 (n)
(Monodelphis domestica)
Mammalia IGSF21 35
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia IGSF21 35
  • 70 (a)
(Gallus gallus)
Aves IGSF21 34 35
  • 77.29 (n)
(Anolis carolinensis)
Reptilia IGSF21 35
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia igsf21 34
  • 74.28 (n)
(Danio rerio)
Actinopterygii igsf21a 34 35
  • 69.69 (n)
igsf21b 35
  • 64 (a)
Species where no ortholog for IGSF21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGSF21 Gene

Gene Tree for IGSF21 (if available)
Gene Tree for IGSF21 (if available)

Paralogs for IGSF21 Gene Pseudogenes for IGSF21 Gene

genes like me logo Genes that share paralogs with IGSF21: view

No data available for Paralogs for IGSF21 Gene

Variants for IGSF21 Gene

Sequence variations from dbSNP and Humsavar for IGSF21 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs766575681 A colorectal cancer sample 18,378,322(+) GCTGA(A/C/T)GTGAA reference, missense
rs1003741 -- 18,251,581(+) tggag(G/T)tggct intron-variant
rs1004218 -- 18,192,875(+) TGGGC(C/T)GATTC intron-variant
rs1004219 -- 18,192,898(+) CGACA(C/T)ATATT intron-variant
rs100622 -- 18,267,873(+) ATTCA(C/G)TCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGSF21 Gene

Variant ID Type Subtype PubMed ID
dgv130n100 CNV loss 25217958
dgv177n54 CNV loss 21841781
dgv20e212 CNV loss 25503493
esv3585384 CNV loss 21293372
esv3585386 CNV loss 21293372
esv994039 CNV deletion 20482838
nsv1075264 CNV deletion 25765185
nsv1114938 CNV deletion 24896259
nsv1133820 CNV deletion 24896259
nsv1137738 CNV deletion 24896259
nsv1142750 CNV deletion 24896259
nsv1151366 CNV deletion 26484159
nsv1160182 CNV duplication 26073780
nsv4409 CNV insertion 18451855
nsv4520 CNV insertion 18451855
nsv460684 CNV loss 19166990
nsv4631 CNV insertion 18451855
nsv4743 CNV deletion 18451855
nsv475630 CNV novel sequence insertion 20440878
nsv478816 CNV novel sequence insertion 20440878
nsv528445 CNV loss 19592680
nsv545713 CNV loss 21841781
nsv545714 CNV loss 21841781
nsv545715 CNV loss 21841781
nsv834313 CNV loss 17160897
nsv834324 CNV gain 17160897
nsv834336 CNV loss 17160897
nsv954894 CNV deletion 24416366

Variation tolerance for IGSF21 Gene

Residual Variation Intolerance Score: 17.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.04; 68.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGSF21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGSF21 Gene

Disorders for IGSF21 Gene

Relevant External Links for IGSF21

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IGSF21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGSF21 Gene

Publications for IGSF21 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for IGSF21 Gene

Sources for IGSF21 Gene

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