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IGSF21 Gene

protein-coding   GIFtS: 50
GCID: GC01P018434

Immunoglobin Superfamily, Member 21

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immunoglobin Superfamily, Member 211 2
Immunoglobulin Superfamily Member 212
IgSF213

External Ids:    HGNC: 282461   Entrez Gene: 849662   Ensembl: ENSG000001171547   UniProtKB: Q96ID53   

Export aliases for IGSF21 gene to outside databases

Previous GC identifers: GC01P018180 GC01P018306 GC01P016680


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IGSF21 Gene:
This gene encodes a protein which has two immunoglobulin (Ig) domains and is a member of the immunoglobulin
superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in
immune response pathways. (provided by RefSeq, Sep 2011)

GeneCards Summary for IGSF21 Gene:
IGSF21 (immunoglobin superfamily, member 21) is a protein-coding gene.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the IGSF21 gene promoter:
         Sp1   MyoD   IRF-1   Tal-1beta   AP-2gamma   E47   POU2F1   POU2F1a   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIGSF21 promoter sequence
   Search Chromatin IP Primers for IGSF21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IGSF21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

IGSF21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGSF21 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P018434:  view genomic region     (about GC identifiers)

Start:
18,434,240 bp from pter      End:
18,704,977 bp from pter
Size:
270,738 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IGS21_HUMAN, Q96ID5 (See protein sequence)
Recommended Name: Immunoglobulin superfamily member 21 precursor  
Size: 467 amino acids; 51835 Da
Secondary accessions: Q8NBR8

Explore the universe of human proteins at neXtProt for IGSF21: NX_Q96ID5

Explore proteomics data for IGSF21 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn82, Asn165, Asn407, Asn444

  • See IGSF21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116269.3  
    ENSEMBL proteins: 
     ENSP00000251296   ENSP00000388681  

    IGSF21 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for IGSF21

     
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    Cloud-Clone Corp. ELISAs for IGSF21
    Cloud-Clone Corp. CLIAs for IGSF21
    Search eBioscience for ELISAs for IGSF21 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q96ID5

    ProtoNet protein and cluster: Q96ID5

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: IGS21_HUMAN, Q96ID5
    Similarity: Contains 2 Ig-like (immunoglobulin-like) domains


    Find genes that share domains with IGSF21           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with IGSF21           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IGSF21:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IGSF21
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    miRNA
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    miRTarBase miRNAs that target IGSF21:
    hsa-mir-335-5p (MIRT019159)

    Block miRNA regulation of human, mouse, rat IGSF21 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate IGSF21:
    hsa-miR-3185
    SwitchGear 3'UTR luciferase reporter plasmidIGSF21 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IGSF21
    Predesigned siRNA for gene silencing in human, mouse, rat IGSF21

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGSF21

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IGS21_HUMAN, Q96ID5: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with IGSF21           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IGSF21
    Interactions:

        Search GeneGlobe Interaction Network for IGSF21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for IGSF21 (Q96ID52, 3 ENSP000002512964) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NREPQ166122, 3, ENSP000004033834MINT-64285 I2D: score=4 STRING: ENSP00000403383
    ALDH2P050912, 3MINT-63387 I2D: score=4 
    ANXA3P124292, 3MINT-63463 I2D: score=4 
    BTBD2Q9BX702, 3MINT-65389 I2D: score=4 
    ERHP840902, 3MINT-64025 I2D: score=4 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IGSF21 (IGS21)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IGSF21 gene: 
    NM_032880.4  

    Unigene Cluster for IGSF21:

    Immunoglobin superfamily, member 21
    Hs.212511  [show with all ESTs]
    Unigene Representative Sequence: NM_032880
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251296(uc001bau.2) ENST00000412684 ENST00000497331(uc001bav.2)
    ENST00000473951
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IGSF21 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate IGSF21:
    hsa-miR-3185
    SwitchGear 3'UTR luciferase reporter plasmidIGSF21 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for IGSF21
    Predesigned siRNA for gene silencing in human, mouse, rat IGSF21
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    Primer
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    OriGene qPCR primer pairs and template standards for IGSF21
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IGSF21
      QuantiTect SYBR Green Assays in human, mouse, rat IGSF21
      QuantiFast Probe-based Assays in human, mouse, rat IGSF21

    Additional mRNA sequence: 

    AK075316.1 AK294121.1 BC007618.1 

    4 DOTS entries:

    DT.215471  DT.101977213  DT.91902680  DT.95176500 

    Selected AceView cDNA sequences (see all 98):

    CR610302 BU727314 BC007618 F04956 BI758183 BM710418 AX747631 BQ068297 
    AK092618 BF346623 CR593587 R52319 D51740 T33909 AA363868 BM548085 
    T31138 BM805251 F04609 BF348142 BF528769 D59739 NM_032880 AW163729 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IGSF21 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12
    SP1:              -                       -     -                 -     -                                 
    SP2:                                                              -     -                                 
    SP3:                                      -     -                                                         
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for IGSF21

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IGSF21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCGCTGCA
    IGSF21 Expression
    About this image


    IGSF21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             brain/midbrain/lateral wall   
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
             brain/midbrain/lateral wall   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Neurons
             Mature Rod Bipolar Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Mature Rod Bipolar Cells Inner Nuclear Layer
    IGSF21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IGSF21 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.212511
        Custom PCR Arrays for IGSF21
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGSF21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IGSF21 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Igsf211 , 5 immunoglobin superfamily, member 215
    immunoglobulin superfamily, member 211
    87.72(n)1
    94.43(a)1
      4 (71.09 cM)5
    2308681  NM_198610.21  NP_941012.11 
     1400268465 
    chicken
    (Gallus gallus)
    Aves IGSF211 immunoglobin superfamily, member 21 77.29(n)
    84.99(a)
      419359  XM_004947285.1  XP_004947342.1 
    lizard
    (Anolis carolinensis)
    Reptilia IGSF216
    immunoglobin superfamily, member 21
    78(a)
    1 ↔ 1
    GL344239.1(1549-67214)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia igsf211 immunoglobin superfamily, member 21 74.28(n)
    82.13(a)
      779688  NM_001078772.2  NP_001072240.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BI428490.12   -- 76.26(n)    BI428490.1 


    ENSEMBL Gene Tree for IGSF21 (if available)
    TreeFam Gene Tree for IGSF21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IGSF21 gene

    Find genes that share paralogs with IGSF21           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for IGSF21
    PGOHUM00000242833


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IGSF21 (see all 6398)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355184
    A colorectal cancer sample4--see VAR_0355182 T M mis40--------
    rs801489071,2
    C,F--16680825(+) GCGAGG/AGGAGG 1 -- ut511Minor allele frequency- A:0.00NA 2
    rs1126803141,2
    C--16680959(+) AGAACC/TGCGGC 1 -- ut510--------
    rs37671091,2
    C--16680988(+) GAGCGC/TGAGGG 1 -- ut510--------
    rs1863572771,2
    --16681024(+) CGAGTC/GGAGCC 1 -- ut510--------
    rs96603911,2
    C--16681103(+) GCCTCC/GGCCAG 1 -- ut51 ese30--------
    rs346029811,2
    F--16782354(+) TTTTTC/TAGTAG 1 -- int12Minor allele frequency- T:0.50NA 4
    rs104659161,2
    C,F,A,H--16797798(+) CTCTCT/ACACAC 1 -- int1 trp32Minor allele frequency- A:0.50NA CSA 4
    rs349472141,2
    C--16811809(+) CTGAG-/CTACTACT 1 -- int10--------
    rs1418501791,2
    --16846267(+) CTTTC-/TGTCTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for IGSF21 (18434240 - 18684240 bp, first 250kb of IGSF21)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IGSF21 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744697CNV Deletion23290073
    esv2744674CNV Deletion23290073
    esv2744730CNV Deletion23290073
    esv994039CNV Deletion20482838
    esv2744719CNV Deletion23290073
    esv2744652CNV Deletion23290073
    esv2744685CNV Deletion23290073
    esv2744663CNV Deletion23290073
    esv2744708CNV Deletion23290073
    nsv4520CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IGSF21
    DNA2.0 Custom Variant and Variant Library Synthesis for IGSF21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with IGSF21           About GenesLikeMe

    Genetic Association Database (GAD): IGSF21
    Human Genome Epidemiology (HuGE) Navigator: IGSF21 (2 documents)

    Export disorders for IGSF21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IGSF21 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with IGSF21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Genome-wide meta-analysis for severe diabetic retinopathy. (PubMed id 21441570)1 Grassi M.A....Nicolae D.L. (Hum. Mol. Genet. 2011)
    8. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    9. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)1 Kerns S.L....Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84966 HGNC: 28246 AceView: MGC15730 Ensembl:ENSG00000117154 euGenes: HUgn84966
    ECgene: IGSF21 H-InvDB: IGSF21

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IGSF21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IGSF21 gene:
    Search GeneIP for patents involving IGSF21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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