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Aliases for IGSF11 Gene

Aliases for IGSF11 Gene

  • Immunoglobulin Superfamily Member 11 2 3 5
  • Brain And Testis-Specific Immunoglobulin Superfamily Protein 3 4
  • V-Set And Immunoglobulin Domain-Containing Protein 3 3 4
  • Immunoglobulin Superfamily, Member 11 2 3
  • Cancer/Testis Antigen 119 2 3
  • BT-IgSF 3 4
  • CXADRL1 3 4
  • VSIG3 3 4
  • Brain And Testis-Specific Immunoglobin Superfamily Protein 3
  • V-Set And Immunoglobulin Domain Containing 3 3
  • CXADR Like 1 3
  • IgSF13 3
  • BTIGSF 4
  • IgSF11 4
  • CT119 3

External Ids for IGSF11 Gene

Previous GeneCards Identifiers for IGSF11 Gene

  • GC03M118248
  • GC03M119900
  • GC03M119941
  • GC03M119940
  • GC03M120102
  • GC03M118619
  • GC03M115994

Summaries for IGSF11 Gene

Entrez Gene Summary for IGSF11 Gene

  • IGSF11 is an immunoglobulin (Ig) superfamily member that is preferentially expressed in brain and testis. It shares significant homology with coxsackievirus and adenovirus receptor (CXADR; MIM 602621) and endothelial cell-selective adhesion molecule (ESAM).[supplied by OMIM, Apr 2005]

GeneCards Summary for IGSF11 Gene

IGSF11 (Immunoglobulin Superfamily Member 11) is a Protein Coding gene. An important paralog of this gene is CXADR.

UniProtKB/Swiss-Prot for IGSF11 Gene

  • Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGSF11 Gene

Genomics for IGSF11 Gene

Regulatory Elements for IGSF11 Gene

Enhancers for IGSF11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IGSF11 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGSF11 Gene

118,900,557 bp from pter
119,146,068 bp from pter
245,512 bases
Minus strand

Genomic View for IGSF11 Gene

Genes around IGSF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGSF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGSF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGSF11 Gene

Proteins for IGSF11 Gene

  • Protein details for IGSF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin superfamily member 11
    Protein Accession:
    Secondary Accessions:
    • C9JZN0
    • Q8N4F1
    • Q8N7T8
    • Q8NDD2

    Protein attributes for IGSF11 Gene

    431 amino acids
    Molecular mass:
    46120 Da
    Quaternary structure:
    No Data Available
    • The last 20 cytoplasmic amino acids are not required for the cell adhesion function.

    Alternative splice isoforms for IGSF11 Gene


neXtProt entry for IGSF11 Gene

Proteomics data for IGSF11 Gene at MOPED

Post-translational modifications for IGSF11 Gene

No data available for DME Specific Peptides for IGSF11 Gene

Domains & Families for IGSF11 Gene

Gene Families for IGSF11 Gene

Protein Domains for IGSF11 Gene

Suggested Antigen Peptide Sequences for IGSF11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with IGSF11: view

Function for IGSF11 Gene

Molecular function for IGSF11 Gene

UniProtKB/Swiss-Prot Function:
Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth.
genes like me logo Genes that share phenotypes with IGSF11: view

Animal Models for IGSF11 Gene

MGI Knock Outs for IGSF11:

Animal Model Products

  • Taconic Biosciences Mouse Models for IGSF11

miRNA for IGSF11 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGSF11 Gene

Localization for IGSF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGSF11 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for IGSF11 Gene COMPARTMENTS Subcellular localization image for IGSF11 gene
Compartment Confidence
extracellular 5
plasma membrane 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for IGSF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with IGSF11: view

Pathways & Interactions for IGSF11 Gene

SuperPathways for IGSF11 Gene

No Data Available

Interacting Proteins for IGSF11 Gene

Gene Ontology (GO) - Biological Process for IGSF11 Gene


No data available for Pathways by source and SIGNOR curated interactions for IGSF11 Gene

Drugs & Compounds for IGSF11 Gene

No Compound Related Data Available

Transcripts for IGSF11 Gene

Unigene Clusters for IGSF11 Gene

Immunoglobulin superfamily, member 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IGSF11 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - -
SP4: -

Relevant External Links for IGSF11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGSF11 Gene

mRNA expression in normal human tissues for IGSF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGSF11 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.0) and Testis (x4.5).

Protein differential expression in normal tissues from HIPED for IGSF11 Gene

This gene is overexpressed in Frontal cortex (39.1) and Adrenal (27.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGSF11 Gene

SOURCE GeneReport for Unigene cluster for IGSF11 Gene Hs.112873

mRNA Expression by UniProt/SwissProt for IGSF11 Gene

Tissue specificity: Abundantly expressed in testis and ovary and to a lower extent in brain, kidney and skeletal muscle.
genes like me logo Genes that share expression patterns with IGSF11: view

Protein tissue co-expression partners for IGSF11 Gene

- Elite partner

Primer Products

Orthologs for IGSF11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGSF11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IGSF11 35
  • 90.02 (n)
  • 92.34 (a)
IGSF11 36
  • 91 (a)
(Canis familiaris)
Mammalia IGSF11 35
  • 91.87 (n)
  • 94.5 (a)
IGSF11 36
  • 94 (a)
(Mus musculus)
Mammalia Igsf11 35
  • 86.37 (n)
  • 89.02 (a)
Igsf11 16
Igsf11 36
  • 89 (a)
(Pan troglodytes)
Mammalia IGSF11 35
  • 99.46 (n)
  • 99.3 (a)
IGSF11 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Igsf11 35
  • 85.9 (n)
  • 89.49 (a)
(Monodelphis domestica)
Mammalia IGSF11 36
  • 82 (a)
(Gallus gallus)
Aves IGSF11 35
  • 73.59 (n)
  • 75.36 (a)
IGSF11 36
  • 71 (a)
(Anolis carolinensis)
Reptilia IGSF11 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia igsf11 35
  • 63.16 (n)
  • 62.6 (a)
(Danio rerio)
Actinopterygii igsf11 35
  • 64.69 (n)
  • 67.33 (a)
igsf11 36
  • 62 (a)
Species with no ortholog for IGSF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGSF11 Gene

Gene Tree for IGSF11 (if available)
Gene Tree for IGSF11 (if available)

Paralogs for IGSF11 Gene

Paralogs for IGSF11 Gene

(6) SIMAP similar genes for IGSF11 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IGSF11: view

Variants for IGSF11 Gene

Sequence variations from dbSNP and Humsavar for IGSF11 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2903250 - 118,930,213(+) TGCTG(G/T)CTGAC reference, missense, utr-variant-5-prime
rs36052974 - 118,902,817(-) ACAGA(G/T)TCAGT downstream-variant-500B, reference, missense, utr-variant-3-prime
rs34908332 - 118,902,653(-) CAGGA(A/G/T)CAATG downstream-variant-500B, reference, missense
rs35857 -- 119,031,565(+) AAGTA(C/G)TTTTA intron-variant
rs35858 -- 119,032,058(+) AAATA(A/T)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGSF11 Gene

Variant ID Type Subtype PubMed ID
nsv3960 CNV Insertion 18451855
nsv822226 CNV Loss 20364138
dgv5235n71 CNV Gain 21882294
nsv877370 CNV Gain 21882294
esv33349 CNV Gain 17666407
nsv829692 CNV Loss 17160897
nsv470860 CNV Gain 18288195
nsv523926 CNV Gain 19592680
dgv618n27 CNV Gain 19166990
dgv5236n71 CNV Gain 21882294
nsv3961 CNV Loss 18451855
esv271379 CNV Insertion 20981092
nsv521267 CNV Gain 19592680
esv25249 CNV Loss 19812545
esv2725820 CNV Deletion 23290073

Variation tolerance for IGSF11 Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.34; 85.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IGSF11 Gene

Disorders for IGSF11 Gene

Relevant External Links for IGSF11

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IGSF11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGSF11 Gene

Publications for IGSF11 Gene

  1. BT-IgSF, a novel immunoglobulin superfamily protein, functions as a cell adhesion molecule. (PMID: 15795899) Harada H. … Okada S. (J. Cell. Physiol. 2005) 3 4 23 67
  2. Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. (PMID: 16108831) Watanabe T. … Nakamura Y. (Cancer Sci. 2005) 3 23
  3. IGSF11 gene, frequently up-regulated in intestinal-type gastric cancer, encodes adhesion molecule homologous to CXADR, FLJ22415 and ESAM. (PMID: 12851705) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 3 23
  4. Molecular cloning of a novel immunoglobulin superfamily gene preferentially expressed by brain and testis. (PMID: 12207903) Suzu S. … Motoyoshi K. (Biochem. Biophys. Res. Commun. 2002) 2 3
  5. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry J.R. … Ong K.K. (Nature 2014) 3

Products for IGSF11 Gene

Sources for IGSF11 Gene