IGSF11 Gene

Aliases
for IGSF11 gene

Previous GC identifers: GC03M118248 GC03M119900 GC03M119941 GC03M119940 GC03M120102 GC03M115994

Summaries
for IGSF11 gene

Genomic Views
for IGSF11 gene

RefSeq DNA sequence:

NC_000003.11  NC_018914.1  NT_005612.16  

SwitchGear Promoter luciferase reporter plasmids (see all 2): IGSF11 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGSF11

IGSF11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M118619:  view genomic region     (about GC identifiers)

Proteins
for IGSF11 gene

Explore the universe of human proteins at neXtProt for IGSF11: NX_Q5DX21

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: IGSF11 OriGene Protein Over-expression Lysate: IGSF11 OriGene Custom Protein Services for IGSF11
	GenScript Custom Purified and Recombinant Proteins Services for IGSF11
	Novus Biologicals IGSF11 Protein Novus Biologicals IGSF11 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for IGSF11

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for IGSF11 (VSIG3)
	Browse OriGene Antibodies OriGene Custom Antibody Services for IGSF11
	GenScript Custom Superior Antibodies Services for IGSF11
	Novus Biologicals IGSF11 Antibodies
	Search for Antibodies for IGSF11 at Abcam
	Uscn Antibodies for IGSF11
	ThermoFisher Antibodies for IGSF11

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for IGSF11
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for IGSF11

Protein Domains /
Families
for IGSF11 gene

ProtoNet protein and cluster: Q5DX21

Function
for IGSF11 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): IGSF11 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IGSF11
		8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate IGSF11 (see all 42):
		hsa-miR-579 hsa-miR-548j hsa-miR-548l hsa-miR-105 hsa-miR-183* hsa-miR-186 hsa-miR-548d-5p hsa-miR-548a-5p
		SwitchGear 3'UTR luciferase reporter plasmid: IGSF11 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IGSF11 (see all 6) OriGene siRNA: IGSF11
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IGSF11

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for IGSF11

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IGSF11 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IGSF11 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): IGSF11 (NM_152538)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for IGSF11
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IGSF11

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IGSF11
		Search LifeMap BioReagents cell lines for IGSF11

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGSF11

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

Pathways & Interactions
for IGSF11 gene

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for IGSF11 gene

Transcripts
for IGSF11 gene

Expression
for IGSF11 gene

IGSF11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACACTGAAAA

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic Angioblasts			Endothelium
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Posterior foregut-like cells (A scalable, suspensi...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IGSF11 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IGSF11
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IGSF11
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IGSF11

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGSF11

Orthologs
for IGSF11 gene

Paralogs
for IGSF11 gene

Paralogs for IGSF11 gene

CLMP²  ESAM²  VSIG8²  GPA33²  JAM2²  VSIG1²  CXADR²  VSIG2²  

C1orf204²  JAM3²  F11R²  

6 SIMAP similar genes for IGSF11 using alignment to 6 protein entries:     IGS11_HUMAN (see all proteins):

CD7    IGKV A18    GPA33    ESAM    CXADR    VSIG2

IGSF11 for paralogs           About GeneDecksing

Genomic Variants
for IGSF11 gene

10/4097 NCBI SNPs in IGSF11 are shown (see all 4097)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1869693131,2	C,	unknown	118646351(+)	ATCCCC/TGACTT	2	--	int1		0	--	--	--	--
rs347859341,2	C,F,	--	118619070(+)	AGGAAG/TGATCC	2	--	ds5001		3		NA	6
rs1808474381,2		--	118619111(+)	TAACTC/TGACTT	2	--	ds5001		0	--	--	--	--
rs1865197641,2		--	118619194(+)	TTCAGC/TGGTGA	2	--	ds5001		0	--	--	--	--
rs729668521,2	C,	--	118619247(+)	GGAAAT/AGGGAA	2	--	ds5001		2		WA	120
rs1913302281,2		--	118619257(+)	AAATAC/GCTCAA	2	--	ds5001		0	--	--	--	--
rs1817017231,2		--	118619268(+)	TGTATA/GAAGAA	2	--	ds5001		0	--	--	--	--
rs1859557751,2		--	118619298(+)	TATGGA/GTAAGA	2	--	ds5001		0	--	--	--	--
rs757836501,2		--	118619534(+)	AATGCA/CAGATA	2	--	ut31		0	--	--	--	--
rs1142615951,2	C,F,	--	118619670(+)	AAAAAA/CATAAG	2	--	ut31		1		WA	118

HapMap Linkage Disequilibrium report for IGSF11 (118619404 - 118864915 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for IGSF11
     4 CNVs: 63565 53713 29731 7355

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGSF11

DNA2.0 Custom Variant and Variant Library Synthesis for IGSF11

Disorders / Diseases
for IGSF11 gene

Publications
for IGSF11 gene

PubMed articles for IGSF11 gene, integrated from 9 sources (see all 11): (articles sorted by number of sources associating them with IGSF11)

Utopia: connect your pdf to the dynamic world of online information

1. BT-IgSF, a novel immunoglobulin superfamily protein, functions as a cell adhesion molecule. (PubMed id 15795899)^{1, 2, 9} Harada H.... Okada S. (2005)
2. IGSF11 gene, frequently up-regulated in intestinal-type gastric cancer, encodes adhesion molecule homologous to CXADR, FLJ22415 and ESAM. (PubMed id 12851705)^{1, 2, 9} Katoh M. and Katoh M. (2003)
3. Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. (PubMed id 16108831)^{1, 2, 9} Watanabe T....Nakamura Y. (2005)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
5. Molecular cloning of a novel immunoglobulin superfamily gene preferentially expressed by brain and testis. (PubMed id 12207903)^{1, 3} Suzu S....Motoyoshi K. (2002)
6. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
8. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)² Muzny D.M....Gibbs R.A. (2006)
9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)¹ Clark H.F.... Gray A.M. (2003)

External Searches for IGSF11 gene

Genome Databases showing IGSF11 gene

Other Databases showing IGSF11 gene

Specialized Databases showing IGSF11 gene

Products
for IGSF11 gene