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Aliases for IGSF10 Gene

Aliases for IGSF10 Gene

  • Immunoglobulin Superfamily, Member 10 2 3
  • Calvaria Mechanical Force Protein 608 3 4
  • CMF608 3 4
  • Immunoglobulin Superfamily Member 10 3
  • IgSF10 4

External Ids for IGSF10 Gene

Previous GeneCards Identifiers for IGSF10 Gene

  • GC03M152476
  • GC03M152637
  • GC03M151143
  • GC03M148533

Summaries for IGSF10 Gene

GeneCards Summary for IGSF10 Gene

IGSF10 (Immunoglobulin Superfamily, Member 10) is a Protein Coding gene. An important paralog of this gene is PTK7.

UniProtKB/Swiss-Prot for IGSF10 Gene

  • May be involved in the maintenance of osteochondroprogenitor cells pool.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGSF10 Gene

Genomics for IGSF10 Gene

Regulatory Elements for IGSF10 Gene

Genomic Location for IGSF10 Gene

Start:
151,425,384 bp from pter
End:
151,539,405 bp from pter
Size:
114,022 bases
Orientation:
Minus strand

Genomic View for IGSF10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IGSF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGSF10 Gene

Proteins for IGSF10 Gene

  • Protein details for IGSF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6WRI0-IGS10_HUMAN
    Recommended name:
    Immunoglobulin superfamily member 10
    Protein Accession:
    Q6WRI0
    Secondary Accessions:
    • Q86YJ9
    • Q8N772
    • Q8NA84

    Protein attributes for IGSF10 Gene

    Size:
    2623 amino acids
    Molecular mass:
    290838 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05429.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for IGSF10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGSF10 Gene

Proteomics data for IGSF10 Gene at MOPED

Post-translational modifications for IGSF10 Gene

  • Glycosylation at Asn319, Asn439, Asn627, Asn774, Asn999, Thr1630, Asn1899, Asn1962, and Asn2101
  • Modification sites at PhosphoSitePlus

Other Protein References for IGSF10 Gene

No data available for DME Specific Peptides for IGSF10 Gene

Domains for IGSF10 Gene

Gene Families for IGSF10 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing

Suggested Antigen Peptide Sequences for IGSF10 Gene

Graphical View of Domain Structure for InterPro Entry

Q6WRI0

UniProtKB/Swiss-Prot:

IGS10_HUMAN :
  • Q6WRI0
Domain:
  • Contains 12 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 6 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with IGSF10: view

Function for IGSF10 Gene

Molecular function for IGSF10 Gene

UniProtKB/Swiss-Prot Function: May be involved in the maintenance of osteochondroprogenitor cells pool.

Gene Ontology (GO) - Molecular Function for IGSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IGSF10: view

Phenotypes for IGSF10 Gene

GenomeRNAi human phenotypes for IGSF10:
genes like me logo Genes that share phenotypes with IGSF10: view

Animal Model Products

CRISPR Products

miRNA for IGSF10 Gene

miRTarBase miRNAs that target IGSF10

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IGSF10 Gene

Localization for IGSF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGSF10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IGSF10 Gene COMPARTMENTS Subcellular localization image for IGSF10 gene
Compartment Confidence
extracellular 3
plasma membrane 3
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IGSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with IGSF10: view

Pathways for IGSF10 Gene

SuperPathways for IGSF10 Gene

No Data Available

Interacting Proteins for IGSF10 Gene

Gene Ontology (GO) - Biological Process for IGSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0007275 multicellular organismal development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with IGSF10: view

No data available for Pathways by source for IGSF10 Gene

Compounds for IGSF10 Gene

(1) Drugbank Compounds for IGSF10 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Pyridoxal Phosphate
  • Codecarboxylase
54-47-7 target cofactor
genes like me logo Genes that share compounds with IGSF10: view

Transcripts for IGSF10 Gene

Unigene Clusters for IGSF10 Gene

Immunoglobulin superfamily, member 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IGSF10

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IGSF10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGSF10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - -
SP2: -
SP3:

Relevant External Links for IGSF10 Gene

GeneLoc Exon Structure for
IGSF10
ECgene alternative splicing isoforms for
IGSF10

Expression for IGSF10 Gene

mRNA expression in normal human tissues for IGSF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGSF10 Gene

This gene is overexpressed in Ovary (12.4) and Lung (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IGSF10 Gene

SOURCE GeneReport for Unigene cluster for IGSF10 Gene Hs.58561

genes like me logo Genes that share expressions with IGSF10: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IGSF10 Gene

Orthologs for IGSF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGSF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGSF10 35
  • 99.43 (n)
  • 99.05 (a)
IGSF10 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 89 (a)
OneToMany
IGSF10 35
  • 82.08 (n)
  • 75.42 (a)
IGSF10 36
  • 74 (a)
OneToMany
dog
(Canis familiaris)
Mammalia IGSF10 35
  • 84.22 (n)
  • 78.37 (a)
IGSF10 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igsf10 35
  • 76.26 (n)
  • 66.05 (a)
Igsf10 16
Igsf10 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGSF10 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGSF10 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igsf10 35
  • 75.31 (n)
  • 65.43 (a)
chicken
(Gallus gallus)
Aves IGSF10 35
  • 60.78 (n)
  • 55.64 (a)
IGSF10 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGSF10 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igsf10 35
  • 62.86 (n)
  • 58.7 (a)
zebrafish
(Danio rerio)
Actinopterygii IGSF10 36
  • 39 (a)
OneToOne
Species with no ortholog for IGSF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGSF10 Gene

ENSEMBL:
Gene Tree for IGSF10 (if available)
TreeFam:
Gene Tree for IGSF10 (if available)

Paralogs for IGSF10 Gene

Paralogs for IGSF10 Gene

Selected SIMAP similar genes for IGSF10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IGSF10: view

Variants for IGSF10 Gene

Sequence variations from dbSNP and Humsavar for IGSF10 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs730878 -- 151,438,863(+) ATATA(G/T)ATAGA intron-variant
rs937125 -- 151,440,477(-) GTTTC(C/T)CTTCC intron-variant
rs937126 -- 151,440,396(-) AAAAA(A/T)TTTCT intron-variant
rs937127 -- 151,438,899(-) ATGGA(C/T)ATGCT intron-variant
rs1491973 -- 151,459,571(+) AGCTT(C/G)GGACA upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IGSF10 Gene

Variant ID Type Subtype PubMed ID
nsv829757 CNV Loss 17160897
nsv4063 CNV Insertion 18451855
nsv508960 CNV Insertion 20534489
nsv877649 CNV Loss 21882294
esv273729 CNV Insertion 20981092
nsv877650 CNV Gain 21882294

Relevant External Links for IGSF10 Gene

HapMap Linkage Disequilibrium report
IGSF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGSF10 Gene

Disorders for IGSF10 Gene

Relevant External Links for IGSF10

Genetic Association Database (GAD)
IGSF10
genes like me logo Genes that share disorders with IGSF10: view

No data available for UniProtKB/Swiss-Prot for IGSF10 Gene

Publications for IGSF10 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. CMF608 -- a novel mechanical strain-induced bone-specific protein expressed in early osteochondroprogenitor cells. (PMID: 14962803) Segev O. … Feinstein E. (Bone 2004) 4

Products for IGSF10 Gene

Sources for IGSF10 Gene

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