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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IGSF10 Gene

protein-coding GIFtS: 47
GCID: GC03M151143

immunoglobulin superfamily, member 10

Explore 2 diseases affiliated with
IGSF10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Immunoglobulin Superfamily, Member 10¹ ²
CMF608¹ ² ³
Calvaria Mechanical Force Protein 608² ³
FLJ25972¹
Immunoglobulin Superfamily Member 10²
IgSF10³

External Ids:	HGNC: 26384¹	Entrez Gene: 285313²	Ensembl: ENSG00000152580⁷	UniProtKB: Q6WRI0³

Export aliases for IGSF10 gene to outside databases

Previous GC identifers: GC03M152476 GC03M152637 GC03M148533

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: IGS10_HUMAN, Q6WRI0

Function: May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IGSF10 gene promoter:
AML1a FOXD1 Olf-1 Tal-1beta Meis-1b E47 MEF-2A aMEF-2 Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IGSF10 promoter sequence

Search SABiosciences Chromatin IP Primers for IGSF10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IGSF10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.1 Ensembl cytogenetic band: 3q25.1 HGNC cytogenetic band: 3q25.1

IGSF10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IGSF10 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M151143: view genomic region (about GC identifiers)

Start:	151,143,172 bp from pter	End:	151,176,497 bp from pter
Size:	33,326 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IGS10_HUMAN, Q6WRI0 (See protein sequence)

Recommended Name: Immunoglobulin superfamily member 10 precursor

Size: 2623 amino acids; 290838 Da

Subcellular location: Secreted (Potential)

Sequence caution: Sequence=BAC05429.1; Type=Erroneous initiation;

Secondary accessions: Q86YJ9 Q8N772 Q8NA84

Alternative splicing: 3 isoforms: Q6WRI0-1 Q6WRI0-2 Q6WRI0-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IGSF10: NX_Q6WRI0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6WRI0

IGSF10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001171616.1 NP_001171617.1 NP_849144.2

ENSEMBL proteins:

ENSP00000417627 ENSP00000282466

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

IGSF10 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IGSF10 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR003598 Ig_sub2

IPR007110 Ig-like_dom

IPR000483 Cys-rich_flank_reg_C

IPR000372 LRR-contain_N

IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry Q6WRI0

ProtoNet protein and cluster: Q6WRI0

3 Blocks protein families:

IPB000372 Cysteine-rich flanking region

IPB000483 Cysteine-rich flanking region

IPB003599 Immunoglobulin subtype

UniProtKB/Swiss-Prot: IGS10_HUMAN, Q6WRI0

Similarity: Contains 12 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 6 LRR (leucine-rich) repeats

Similarity: Contains 1 LRRCT domain

Similarity: Contains 1 LRRNT domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IGS10_HUMAN, Q6WRI0

Function: May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity)

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IGSF10

2 GenomeRNAi human phenotypes for IGSF10:

Increased gamma-H2AX phosphory

Metaphase cells

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for IGSF10

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for IGSF10 (ENSP00000282466⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PLA2G2D	ENSP00000364246⁴	STRING: ENSP00000364246

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001503	ossification	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0030154	cell differentiation	IEA	--
GO:0042246	tissue regeneration	--	--

IGSF10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IGSF10

1 DrugBank Compound for IGSF10 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Pyridoxal Phosphate	Codecarboxylase (see all 9)	54-47-7	target	cofactor	17139284 17016423 10592235

Search CenterWatch for drugs/clinical trials and news about IGSF10 / IGS10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for IGSF10 gene (3 alternative transcripts):

NM_001178145.1 NM_001178146.1 NM_178822.4

Unigene Cluster for IGSF10:

Immunoglobulin superfamily, member 10

Hs.58561 [show with all ESTs]

Unigene Representative Sequence: NM_178822

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000489791 ENST00000497472 ENST00000282466(uc011bob.2 uc011boc.2 uc011bod.2)

ENST00000493841 ENST00000495443

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		hsa-miR-647 hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-106b hsa-miR-519e hsa-miR-182 hsa-miR-548t

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Additional cDNA sequence:

AK093069.1 AK098838.1 AK128160.1 AY273815.1 BC031063.1 BC045734.1

3 DOTS entries:

DT.40128724 DT.99993706 DT.441996

24/48 AceView cDNA sequences (see all 48):

NM_178822 AW513013 AA236364 CA390554 H89283 AA453870 BU607959 BX282231

AA256881 AY273815 BM681303 AX747900 AA255475 AI685041 BU679993 BC031063

AK128160 AK093069 BI561617 BI464470 H89282 BM930084 AI127041 BM726658

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for IGSF10 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c
SP1:											-		-		-
SP2:															-
SP3:

ECgene alternative splicing isoforms for IGSF10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IGSF10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAAATAAAA

About this image

IGSF10 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Trophoblast-like cells (Generation of tropho...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IGSF10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IGSF10

SOURCE GeneReport for Unigene cluster: Hs.58561

SABiosciences Custom PCR Arrays for IGSF10

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for IGSF10 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	IGSF10¹	immunoglobulin superfamily, member 10	65.17(n) 62.61(a)		425035 XM_422837.3 XP_422837.3
lizard (Anolis carolinensis)	Reptilia	IGSF10⁶	--	48(a)	1 ↔ 1	3(17954381-17977236)
zebrafish (Danio rerio)	Actinopterygii	LOC100329456¹	immunoglobulin superfamily member 10-like	56.92(n) 52.56(a)		100329456 XM_002664516.2 XP_002664562.1
worm (Caenorhabditis elegans)	Secernentea	him-4⁶	High Incidence of Males (increased X chromosome lo...	5(a)	1 → many	X(9717568-9753706)

ENSEMBL Gene Tree for IGSF10 (if available)
TreeFam Gene Tree for IGSF10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IGSF10 gene

VCAM1² HMCN1² ENSG00000215428² PTK7² HMCN2² MXRA5² HSPG2²

1 SIMAP similar gene for IGSF10 using alignment to 2 protein entries: IGS10_HUMAN (see all proteins):

MXRA5

IGSF10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139695323^1,2	F	--	151154975(+)	`GGGATT/CCCATC`	6	/G	syn¹		1		NA	4536
rs111468413^1,2	C,F,	--	151155001(+)	`TGATAG/AAGATT`	6	/L	syn¹		3		CSA WA NA	4652
rs182380302^1,2	C,	--	151155038(+)	`GGTGCA/GTAGGT`	6	Y	syn¹		0	--	--	--	--
rs112300737^1,2	C,F,	--	151155044(+)	`TAGGTA/GAGAAT`	6	L	syn¹		2		NA EU	5851
rs145036931^1,2	C,F	--	151155090(+)	`TCTCAA/GTATAG`	6	T I	mis¹		1		NA	4540
rs111254790^1,2	C,F,	--	151155095(+)	`ATATAG/ACCAAC`	6	/G	syn¹		2		NA EU	5867
rs138165000^1,2	C,F,	--	151155132(+)	`TTCCTG/ACATCC`	6	/A /V	mis¹		1		NA	4526
rs141148204^1,2	C,F	--	151155169(+)	`AGAACC/TATTGC`	6	S G	mis¹		1		NA	4540
rs141741834^1,2	C,F,	--	151155197(+)	`TAACTT/CTGTGG`	6	/Q	syn¹		1		NA	4550
rs141886027^1,2	C,	--	151155225(+)	`TGCCAT/CTTGGT`	6	/N /S	mis¹		1		NA	4548

HapMap Linkage Disequilibrium report for IGSF10 (151143172 - 151176497 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IGSF10: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IGSF10

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IGSF10 for disorders About GeneDecksing

2 diseases for IGSF10: About MalaCards

sjogren's syndrome multiple sclerosis

Export disorders for IGSF10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for IGSF10 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with IGSF10)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)⁷ Imming P....Meyer A. (2006)
How many drug targets are there? (PubMed id 17139284)⁷ Overington J.P....Hopkins A.L. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
CMF608 -- a novel mechanical strain-induced bone-specific protein expressed in early osteochondroprogenitor cells. (PubMed id 14962803)² Segev O....Feinstein E. (2004)
The Protein Data Bank. (PubMed id 10592235)⁷ Berman H.M....Bourne P.E. (2000)
ESIMS--an ongoing clinical trial in secondary progressive multiple sclerosis. (PubMed id 11188776)⁹ Hommes O.R. and Maas-Enriquez M. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 285313	HGNC: 26384	AceView: IGSF10	Ensembl:ENSG00000152580	euGenes: HUgn285313
ECgene: IGSF10	H-InvDB: IGSF10

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IGSF10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IGSF10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for IGSF10 gene:
Search GeneIP for patents involving IGSF10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IGSF10
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes IGSF10 gene at Home site.

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IGSF10 Gene

immunoglobulin superfamily, member 10

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Export list of displayed genes

IGSF10 Gene

immunoglobulin superfamily, member 10

Aliasesfor IGSF10 gene

Summariesfor IGSF10 gene

Genomic Viewsfor IGSF10 gene

Proteinsfor IGSF10 gene

Protein Domains /Familiesfor IGSF10 gene

Functionfor IGSF10 gene

Pathways & Interactionsfor IGSF10 gene

Drugs & Compoundsfor IGSF10 gene

Transcriptsfor IGSF10 gene

Expression for IGSF10 gene

Orthologsfor IGSF10 gene

Paralogsfor IGSF10 gene

Genomic Variantsfor IGSF10 gene

Disorders / Diseasesfor IGSF10 gene

Publicationsfor IGSF10 gene

External Searches for IGSF10 gene

Genome Databases showing IGSF10 gene

Other Databases showing IGSF10 gene

Specialized Databases showing IGSF10 gene

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Productsfor IGSF10 gene

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Aliases
for IGSF10 gene

Summaries
for IGSF10 gene

Genomic Views
for IGSF10 gene

Proteins
for IGSF10 gene

Protein Domains /
Families
for IGSF10 gene

Function
for IGSF10 gene

Pathways & Interactions
for IGSF10 gene

Drugs & Compounds
for IGSF10 gene

Transcripts
for IGSF10 gene

Expression
for IGSF10 gene

Orthologs
for IGSF10 gene

Paralogs
for IGSF10 gene

Genomic Variants
for IGSF10 gene

Disorders / Diseases
for IGSF10 gene

Publications
for IGSF10 gene

Intellectual Property
for IGSF10 gene

Products
for IGSF10 gene