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Aliases for IGSF10 Gene

Aliases for IGSF10 Gene

  • Immunoglobulin Superfamily Member 10 2 3 5
  • Calvaria Mechanical Force Protein 608 3 4
  • CMF608 3 4
  • Immunoglobulin Superfamily, Member 10 2
  • IgSF10 4

External Ids for IGSF10 Gene

Previous GeneCards Identifiers for IGSF10 Gene

  • GC03M152476
  • GC03M152637
  • GC03M151143
  • GC03M148533

Summaries for IGSF10 Gene

GeneCards Summary for IGSF10 Gene

IGSF10 (Immunoglobulin Superfamily Member 10) is a Protein Coding gene. An important paralog of this gene is MXRA5.

UniProtKB/Swiss-Prot for IGSF10 Gene

  • Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons) (By similarity). May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity).

Additional gene information for IGSF10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGSF10 Gene

Genomics for IGSF10 Gene

GeneHancer (GH) Regulatory Elements for IGSF10 Gene

Promoters and enhancers for IGSF10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I151458 Promoter 0.5 EPDnew 550.1 +161.3 161274 0.1 IGSF10 MRPL42P6 GC03P151434
GH03I151813 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 10.2 -195.7 -195744 4.4 ELF3 FOXA2 ZNF48 RAD21 RARA YY1 FOS CREM MIXL1 SMARCA5 AADAC IGSF10 LOC105374160 ENSG00000243273 SUCNR1 AADACL2-AS1
GH03I151303 Enhancer 1.3 Ensembl ENCODE dbSUPER 9.4 +313.6 313614 5.1 CLOCK ARID4B NEUROD1 SIN3A E2F8 FOS DEK MAFF ATF4 ZNF610 P2RY14 P2RY13 IGSF10 GPR87 PIR58282 MED12L
GH03I151168 Enhancer 1 Ensembl ENCODE 9.9 +449.5 449502 3.6 HDGF ELF3 ARID4B RAD21 RFX5 ZNF143 ETV6 IKZF2 RUNX3 DEK P2RY14 MED12L IGSF10 AADAC GC03M151148 GC03P151189
GH03I151169 Enhancer 0.8 ENCODE 9.9 +451.4 451437 0.2 ELF3 CTCF ARID4B MAX CEBPG RAD21 RFX5 TEAD3 ZNF143 SMC3 P2RY14 MED12L IGSF10 GC03M151148 GC03P151189
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGSF10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IGSF10 gene promoter:

Genomic Locations for IGSF10 Gene

Genomic Locations for IGSF10 Gene
194,543 bases
Minus strand

Genomic View for IGSF10 Gene

Genes around IGSF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGSF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGSF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGSF10 Gene

Proteins for IGSF10 Gene

  • Protein details for IGSF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin superfamily member 10
    Protein Accession:
    Secondary Accessions:
    • Q86YJ9
    • Q8N772
    • Q8NA84

    Protein attributes for IGSF10 Gene

    2623 amino acids
    Molecular mass:
    290838 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05429.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for IGSF10 Gene


neXtProt entry for IGSF10 Gene

Post-translational modifications for IGSF10 Gene

  • Glycosylation at posLast=319319, isoforms=439, posLast=627627, isoforms=774, posLast=999999, isoforms=1630, isoforms=1899, isoforms=1962, and posLast=21012101

Other Protein References for IGSF10 Gene

No data available for DME Specific Peptides for IGSF10 Gene

Domains & Families for IGSF10 Gene

Gene Families for IGSF10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for IGSF10 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGSF10: view

No data available for UniProtKB/Swiss-Prot for IGSF10 Gene

Function for IGSF10 Gene

Molecular function for IGSF10 Gene

UniProtKB/Swiss-Prot Function:
Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons) (By similarity). May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity).

Phenotypes From GWAS Catalog for IGSF10 Gene

genes like me logo Genes that share phenotypes with IGSF10: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGSF10 Gene

Localization for IGSF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGSF10 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGSF10 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IGSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA,IEA 27137492
genes like me logo Genes that share ontologies with IGSF10: view

Pathways & Interactions for IGSF10 Gene

SuperPathways for IGSF10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:2001222 regulation of neuron migration ISS,IEA --
genes like me logo Genes that share ontologies with IGSF10: view

No data available for Pathways by source and SIGNOR curated interactions for IGSF10 Gene

Drugs & Compounds for IGSF10 Gene

(1) Drugs for IGSF10 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyridoxal Phosphate Approved, Investigational Nutra Target, cofactor 17
genes like me logo Genes that share compounds with IGSF10: view

Transcripts for IGSF10 Gene

Unigene Clusters for IGSF10 Gene

Immunoglobulin superfamily, member 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGSF10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - -
SP2: -

Relevant External Links for IGSF10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGSF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGSF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGSF10 Gene

This gene is overexpressed in Ovary (x12.4) and Lung (x6.1).

Protein differential expression in normal tissues from HIPED for IGSF10 Gene

This gene is overexpressed in Serum (61.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGSF10 Gene

Protein tissue co-expression partners for IGSF10 Gene

NURSA nuclear receptor signaling pathways regulating expression of IGSF10 Gene:


SOURCE GeneReport for Unigene cluster for IGSF10 Gene:

genes like me logo Genes that share expression patterns with IGSF10: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGSF10 Gene

Orthologs for IGSF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGSF10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IGSF10 33 34
  • 99.43 (n)
(Bos Taurus)
Mammalia -- 34
  • 89 (a)
IGSF10 33 34
  • 82.08 (n)
(Canis familiaris)
Mammalia IGSF10 33 34
  • 84.22 (n)
(Mus musculus)
Mammalia Igsf10 33 16 34
  • 76.26 (n)
(Rattus norvegicus)
Mammalia Igsf10 33
  • 75.31 (n)
(Monodelphis domestica)
Mammalia IGSF10 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia IGSF10 34
  • 54 (a)
(Gallus gallus)
Aves IGSF10 33 34
  • 60.78 (n)
(Anolis carolinensis)
Reptilia IGSF10 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia igsf10 33
  • 62.86 (n)
(Danio rerio)
Actinopterygii IGSF10 34
  • 39 (a)
Species where no ortholog for IGSF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGSF10 Gene

Gene Tree for IGSF10 (if available)
Gene Tree for IGSF10 (if available)

Paralogs for IGSF10 Gene

Paralogs for IGSF10 Gene

(1) SIMAP similar genes for IGSF10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IGSF10: view

Variants for IGSF10 Gene

Sequence variations from dbSNP and Humsavar for IGSF10 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000029000 -- 151,456,795(-) TTTTTTTT/TTTTTTT/TTTTTTTTT genic_upstream_transcript_variant, intron_variant
rs1000040776 -- 151,614,456(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000064356 -- 151,523,918(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000076116 -- 151,606,744(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000077075 -- 151,491,031(-) A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IGSF10 Gene

Variant ID Type Subtype PubMed ID
nsv4063 CNV insertion 18451855
nsv508960 CNV insertion 20534489
nsv829757 CNV loss 17160897

Variation tolerance for IGSF10 Gene

Residual Variation Intolerance Score: 96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.96; 74.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGSF10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGSF10 Gene

Disorders for IGSF10 Gene


  • Note=Mutations in IGSF10 may be a cause of self-limited delayed puberty. This common condition is defined as the absence of testicular enlargement in boys or breast development in girls at an age that is 2-2.5 standard deviations later than the population mean. Self-limited delayed puberty segregates within families, with the majority of families displaying an autosomal dominant pattern of inheritance. {ECO:0000269 PubMed:27137492}.

Additional Disease Information for IGSF10

No disorders were found for IGSF10 Gene.

No data available for MalaCards and Genatlas for IGSF10 Gene

Publications for IGSF10 Gene

  1. IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty. (PMID: 27137492) Howard SR … Dunkel L (EMBO molecular medicine 2016) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for IGSF10 Gene

Sources for IGSF10 Gene

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