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Aliases for IGSF10 Gene

Aliases for IGSF10 Gene

  • Immunoglobulin Superfamily Member 10 2 3 5
  • Calvaria Mechanical Force Protein 608 3 4
  • CMF608 3 4
  • Immunoglobulin Superfamily, Member 10 2
  • IgSF10 4

External Ids for IGSF10 Gene

Previous GeneCards Identifiers for IGSF10 Gene

  • GC03M152476
  • GC03M152637
  • GC03M151143
  • GC03M148533

Summaries for IGSF10 Gene

GeneCards Summary for IGSF10 Gene

IGSF10 (Immunoglobulin Superfamily Member 10) is a Protein Coding gene. An important paralog of this gene is MXRA5.

UniProtKB/Swiss-Prot for IGSF10 Gene

  • May be involved in the maintenance of osteochondroprogenitor cells pool.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGSF10 Gene

Genomics for IGSF10 Gene

Regulatory Elements for IGSF10 Gene

Enhancers for IGSF10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F151426 0.2 Ensembl 10.8 +193.5 193526 0.4 CTCF SMC3 RAD21 IGSF10 GC03P151434 P2RY12
GH03F151933 0.4 ENCODE 10.7 -313.7 -313749 0.9 BACH1 ZNF316 GATA3 CTBP1 RCOR1 NFE2 FOS MAFK NFE2L2 MAFG IGSF10 AADAC AADACL2-AS1 LOC105374161
GH03F151422 0.6 Ensembl 10.6 +197.8 197826 0.2 CTCF P2RY12 IGSF10 ENSG00000241151 GC03P151434
GH03F151362 0.4 Ensembl 10.3 +256.9 256925 1.2 P2RY13 GPR87 P2RY14 IGSF10 ERICH6 P2RY12
GH03F151813 1 Ensembl ENCODE 10.2 -195.7 -195745 4.4 ELF3 ATF1 ZNF48 RAD21 RARA YY1 FOS CREM MIXL1 SP5 AADAC IGSF10 LOC105374160 ENSG00000243273 SUCNR1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IGSF10 on UCSC Golden Path with GeneCards custom track

Genomic Location for IGSF10 Gene

151,425,384 bp from pter
151,619,926 bp from pter
194,543 bases
Minus strand

Genomic View for IGSF10 Gene

Genes around IGSF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGSF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGSF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGSF10 Gene

Proteins for IGSF10 Gene

  • Protein details for IGSF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin superfamily member 10
    Protein Accession:
    Secondary Accessions:
    • Q86YJ9
    • Q8N772
    • Q8NA84

    Protein attributes for IGSF10 Gene

    2623 amino acids
    Molecular mass:
    290838 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05429.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for IGSF10 Gene


neXtProt entry for IGSF10 Gene

Post-translational modifications for IGSF10 Gene

  • Glycosylation at Asn 319, Asn 439, Asn 627, Asn 774, Asn 999, Thr 1630, Asn 1899, Asn 1962, and Asn 2101
  • Modification sites at PhosphoSitePlus

Other Protein References for IGSF10 Gene

No data available for DME Specific Peptides for IGSF10 Gene

Domains & Families for IGSF10 Gene

Gene Families for IGSF10 Gene

Suggested Antigen Peptide Sequences for IGSF10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 12 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 6 LRR (leucine-rich) repeats.
  • Contains 12 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
  • Contains 6 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with IGSF10: view

Function for IGSF10 Gene

Molecular function for IGSF10 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the maintenance of osteochondroprogenitor cells pool.
genes like me logo Genes that share phenotypes with IGSF10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IGSF10

miRNA for IGSF10 Gene

miRTarBase miRNAs that target IGSF10

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGSF10 Gene

Localization for IGSF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGSF10 Gene


Subcellular locations from

Jensen Localization Image for IGSF10 Gene COMPARTMENTS Subcellular localization image for IGSF10 gene
Compartment Confidence
extracellular 4
plasma membrane 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for IGSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with IGSF10: view

Pathways & Interactions for IGSF10 Gene

SuperPathways for IGSF10 Gene

No Data Available

Interacting Proteins for IGSF10 Gene

Gene Ontology (GO) - Biological Process for IGSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with IGSF10: view

No data available for Pathways by source and SIGNOR curated interactions for IGSF10 Gene

Drugs & Compounds for IGSF10 Gene

(1) Drugs for IGSF10 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyridoxal Phosphate Nutra Target, cofactor 14
genes like me logo Genes that share compounds with IGSF10: view

Transcripts for IGSF10 Gene

Unigene Clusters for IGSF10 Gene

Immunoglobulin superfamily, member 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGSF10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - -
SP2: -

Relevant External Links for IGSF10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGSF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGSF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGSF10 Gene

This gene is overexpressed in Ovary (x12.4) and Lung (x6.1).

Protein differential expression in normal tissues from HIPED for IGSF10 Gene

This gene is overexpressed in Serum (61.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGSF10 Gene

Protein tissue co-expression partners for IGSF10 Gene

NURSA nuclear receptor signaling pathways regulating expression of IGSF10 Gene:


SOURCE GeneReport for Unigene cluster for IGSF10 Gene:

genes like me logo Genes that share expression patterns with IGSF10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for IGSF10 Gene

Orthologs for IGSF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGSF10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IGSF10 34 35
  • 99.43 (n)
(Bos Taurus)
Mammalia -- 35
  • 89 (a)
IGSF10 34 35
  • 82.08 (n)
(Canis familiaris)
Mammalia IGSF10 34 35
  • 84.22 (n)
(Mus musculus)
Mammalia Igsf10 34 16 35
  • 76.26 (n)
(Rattus norvegicus)
Mammalia Igsf10 34
  • 75.31 (n)
(Monodelphis domestica)
Mammalia IGSF10 35
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia IGSF10 35
  • 54 (a)
(Gallus gallus)
Aves IGSF10 34 35
  • 60.78 (n)
(Anolis carolinensis)
Reptilia IGSF10 35
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia igsf10 34
  • 62.86 (n)
(Danio rerio)
Actinopterygii IGSF10 35
  • 39 (a)
Species where no ortholog for IGSF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGSF10 Gene

Gene Tree for IGSF10 (if available)
Gene Tree for IGSF10 (if available)

Paralogs for IGSF10 Gene

(1) SIMAP similar genes for IGSF10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IGSF10: view

Variants for IGSF10 Gene

Sequence variations from dbSNP and Humsavar for IGSF10 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10081647 -- 151,571,793(-) AGCAC(A/G)AGGCA intron-variant
rs10433449 -- 151,461,713(+) ttctc(A/T)gatct intron-variant
rs10570378 -- 151,462,003(+) TTAAA(-/TAC)TACTA intron-variant
rs10573996 -- 151,551,672(+) ACACA(-/CA)TCTGA intron-variant
rs10610166 -- 151,435,624(+) ATTCT(-/TAAG/TAAGTAAG)TAAGT downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IGSF10 Gene

Variant ID Type Subtype PubMed ID
nsv4063 CNV insertion 18451855
nsv508960 CNV insertion 20534489
nsv829757 CNV loss 17160897

Variation tolerance for IGSF10 Gene

Residual Variation Intolerance Score: 96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.96; 74.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IGSF10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGSF10 Gene

Disorders for IGSF10 Gene

Relevant External Links for IGSF10

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IGSF10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGSF10 Gene

Publications for IGSF10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. CMF608 -- a novel mechanical strain-induced bone-specific protein expressed in early osteochondroprogenitor cells. (PMID: 14962803) Segev O. … Feinstein E. (Bone 2004) 4 64

Products for IGSF10 Gene

Sources for IGSF10 Gene

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